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Objectives To identify differences in the mean vitamin D concentrations in samples obtained from a private laboratory in Quito and to explore their relationship with the pre-pandemic and pandemic periods spanning from 2018 to 2022.Design A combination of an interrupted time series design and a retrospective cross-sectional approach.Setting and participants The study involved 9285 participants who had their 25-hydroxyvitamin D (25(OH)D) levels tested at a well-known private laboratory in Quito, Ecuador, from 2018 to 2022.Primary and secondary outcome measures The 25(OH)D levels were analysed and assessed for correlations with age, and the year the measurements were taken.Results The mean 25(OH)D level was 27.53 ng/mL (± 14.11). Approximately 68.8% of participants had serum 25(OH)D levels of less than 30 ng/mL, and 0.6% showed potential harm from excess 25(OH)D, with levels over 100 ng/mL. The analysis indicated a significant monthly increase of 0.133 units in 25(OH)D levels (p=0.006). However, the period after March 2020, compared with before, saw a non-significant decrease of 1.605 units in mean 25(OH)D levels (p=0.477).Conclusions The study’s findings indicate a significant prevalence of 25(OH)D deficiency, underscoring the necessity for preventative measures. However, the increasing trend in high 25(OH)D levels is concerning, emphasising the importance of prudent vitamin D supplement prescriptions and public education against self-medication. For efficient resource allocation and targeting of those with higher risks, it may be advantageous to concentrate vitamin D testing on specific population groups.

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Introducción: La obesidad y la adiposidad están relacionadas con el aumento del riesgo cardiovascular. El índice de masa corporal (IMC) y el perímetro abdominal son las variables antropométricas más utilizadas para evaluar su magnitud. El presente estudio busca establecer la relación entre desenlaces cardiometabólicos y la adiposidad medida con Absorciometría Dual por rayos X (DXA), así como el rendimiento diagnóstico de la misma contra la medición de las variables antropométricas convencionales. Materiales y métodos: Se realizó un estudio observacional de corte transversal; se calcularon las variables antropométricas y de composición corporal para 60 pacientes en programa de rehabilitación cardiaca fase II. Resultados: Existió mayor prevalencia de obesidad por IMC y adiposidad en mujeres que en hombres (p=0,01 y 0,048). La curva ROC encontró que el rendimiento del perímetro abdominal es solo 65% y el del IMC del 65,6% para el diagnóstico de adiposidad. Se encontraron relaciones significativas entre porcentaje de masa grasa elevado y la enfermedad coronaria (OR: 1,9 p= 0,042); el IMC aumentado con la hipertensión arterial (OR: 3,0 p= 0,0334) y el LDL > 70 mg/dl (OR: 0,4 p= 0,0178); el perímetro abdominal aumentado con la falla cardiaca (OR: 0,58 p=0,0382); la TMB baja con la hipertensión arterial (OR: 1,70 p= 0,046) y finalmente el IIRME disminuido con el LDL > 70 mg/dl y la falla cardiaca (OR: 0,4 p= 0,0178 y OR 1,96 p=0,078, respectivamente). Conclusiones: La suma de la medición de las variables antropométricas y de composición corporal por DXA ofrece información valiosa para el estudio y estimación del riesgo cardiovascular y metabólico de los pacientes. Abstract Introduction: Obesity and adiposity are associated with increased cardiovascular risk. The body mass index (BMI) and waist circumference are the most anthropometric variables used to assess their magnitude. This study aims to establish the relationship between adiposity and cardiometabolic outcomes measured by Dual X-ray Absorptiometry (DXA) as well as the diagnostic performance of the latter against the measurement of the conventional anthropometric variables. Materials and methods: An observational cross-sectional study was conducted; anthropometric and body composition variables for 60 patients in cardiac rehabilitation program phase II were calculated. Results: There was a higher prevalence of obesity by BMI and adiposity in women than in men (p = 0.01 and 0.048). The ROC curve found that the performance is only 65% for waist circumference and 65.6% for BMI for the diagnosis of adiposity. Significant correlations between high percentage of fat mass and coronary heart disease (OR: 1.9 p = 0.042) were found; as well as for increased BMI with hypertension (OR: 3.0 p = 0.0334) and LDL> 70mg/dl (OR: 0.4 p = 0.0178); increased waist circumference with heart failure (OR: 0.58 p = 0.0382); low basal metabolic rate (BMR) with hypertension (OR: 1.70 p = 0.046) and finally the decreased fat free mass index (FFMI) with LDL>70mg/dl and heart failure (OR: 0.4 p = 0.0178 and OR: 1.96 p = 0.078 respectively). Conclusions: The addition of body composition variables by DXA and anthropometric variables, provides valuable information for the study and estimation of cardiovascular and metabolic risk. Key Words: Obesity; DEXA Scans; Coronary Disease; BodyComposition; Body Mass Index; Adiposity.