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1. Neurological presentations of COVID-19: Findings from the Spanish Society of Neurology neuroCOVID-19 registry

Author

Fernández, Alejandra Collía, Horga, Alejandro, Prieto, Ana Barragán, del Villar Igea, Ana, Núñez, Ana Urbanos, Serrano, Ángel Aledo, García, Araceli, Menéndez, Beatriz Martínez, Recasens, Bernat Bertran, Serrano, Blanca Serrano, de la Esperanza, Blanca Talavera, de la Hoz, Carlos Pablo de Fuenmayor Fernández, Juste, Carlos Tejero, Martín, Carmen Valderrama, García, Cristina Fernández, Ochoa, Marta, Íñiguez, Cristina, García, Daniel Macías, Pérez Martínez, David A., Santacruz, Débora Mª. Cerdán, Robert, Misericòrdia Floriach, Gomez, Elisabet Franquet, Puiggròs, Elsa, Álvarez, Eric Freire, Llamas, Esteban Peña, Villareal, Estibaliz, Díaz, Eva Fernández, Burguillos, Fernando Morejón, Beitia, Garazi Agirre, Gutiérrez-Gutiérrez, Gerardo, Monteiro, Guilherme Carvalho, Ygual, Guillermo Cervera, Hernández, Guillermo, Rubio, Guillermo, Alonso, Hortenia, Froiz, Iago Payo, García, Iago Rego, Peñas, Inmaculada Redondo, Pérez Sánchez, Javier R., García, Javier Tejada, Álvarez, Javier Villacieros, Domínguez, Jéssica Fernández, Etessam, Jesús Porta, Equiza, Jon, Pascual, Jorge Millán, Usieto, José Antonio Oliván, Reyes, José Antonio, Gómez, José Balseiro, Bueno, José Carlos Roche, Velasquez, Jose Luis Camacho, López, José María Barrios, Raquel Lamas, Leire Ainz, Lezama, Lidia Binela Lara, Caballero, Lorena, Davila, Lucía Galan, González, Nuria, de Antonio, Luis Alberto Rodríguez, Torres, Mª. Araceli García, Zabaleta, Maite Martinez, Rodríguez, Manuel Medina, Moragues, María Dolores, García, María Fuensanta Valero, Hernández, María, Abildúa, María José Abenza, Rabasa, María, Santos, María Rico, Usero, María, Zurdo, Martín, Más, Miguel, Maneiro, Miren, Platas, Montserrat González, Muriana, Nafría, Noelia González, Esteve, Oriol Barrachina, del Saz Saucedo, Pablo, Rocío, Vilar Ventura, Rosa M., Atienza, Saida, Navas, Sandra Rodríguez, Fernández, Santiago Fernández, Borja, Sergio, Navarro, Silvia Gil, García, Solange Kapetanovic, García, Susana, Salas, Teresa Mateos, Palasí, Toni, Cantero, Victoriano Romero, García-Azorín, David, Aguirre, María Elena Erro, Moncó, Juan Carlos García, Guijarro-Castro, Cristina, Delgado, Fernando Romero, Andrés, José Miguel Láinez, and Ezpeleta, David

Published
2021
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2. CIRCULACION DEL NEUMOCOCO RELACIONADO A CAMBIOS EN LOS FACTORES CLIMÁTICOS EN LA PROVINCIA DE LA RIOJA

Author

Patricia Cordoba, PhD, Mónica Romanazzi, Sonia Flores, Patricia Torres, and Jose Maria Barrios

Subjects
lcsh:R5-920, lcsh:R, Neumococo, lcsh:Medicine, Factores climáticos, Meningitis, Neumonias, lcsh:Medicine (General)
Abstract

Resumen: Streptococo pneumoniae (Neumococo), Neisseria meningitidis y Haemophilus influenzae producen meningitis bacterianas. Este trabajo describe las caracteristicas del aumento de casos de meningitis bacterianas en la Provincia de la Rioja, Argentina. Se realizó un estudio descriptivo retrospectivo de las meningitis desde 1997 hasta 2001. Se estudió la circulación de los agentes etiologicos; la distribución de las neumonías y bacteriemias producidas por neumococo; las variaciones de la humedad relativa y de las temperaturas promedios (aportadas por el Servicio Meteorológico Nacional). Los casos se estudiaron desde fichas epidemiológicas de la Dirección de epidemiología y de historias clínicas del Hospital "Dr. E. Vera Barros". Los liquidos cefalorraquideos y lavados pleurales o bronquiales se procesaron en el laboratorio de bacteriología. Los aislamientos se remitieron para su serotipificación al laboratorio de referencia nacional. Durante el año 2000, la tasa de incidencia de meningitis fue mayor y la tasa de meningitis por neumococo fue mayor en el periodo estudiado. En ese año, el neumococo aumenta la circulación presentandose aumento de meningitis, neumonias mientras que las infecciones neumococcicas invasivas fueron simirales a otros años. La circulación de los otros agentes etiológico se mantienen constante en el periodo estudiado. Los serotipos circulantes fueron sensibles penicilina. Durante el año 2000 aumenta en la humedad (2-6 puntos) y disminuye la amplitud térmica en los meses simultáneamente a la presencia de los casos de infecciones por neumococo. Los resultados sugieren que la circulación del neumococo en una población estaría relacionada con la alta humedad relativa y la poca amplitud térmica.

Published
2003

3. Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis

Author

Bhagteshwar Singh, Suzannah Lant, Sofia Cividini, Jonathan W. S. Cattrall, Lynsey C. Goodwin, Laura Benjamin, Benedict D. Michael, Ayaz Khawaja, Aline de Moura Brasil Matos, Walid Alkeridy, Andrea Pilotto, Durjoy Lahiri, Rebecca Rawlinson, Sithembinkosi Mhlanga, Evelyn C. Lopez, Brendan F. Sargent, Anushri Somasundaran, Arina Tamborska, Glynn Webb, Komal Younas, Yaqub Al Sami, Heavenna Babu, Tristan Banks, Francesco Cavallieri, Matthew Cohen, Emma Davies, Shalley Dhar, Anna Fajardo Modol, Hamzah Farooq, Jeffrey Harte, Samuel Hey, Albert Joseph, Dileep Karthikappallil, Daniel Kassahun, Gareth Lipunga, Rachel Mason, Thomas Minton, Gabrielle Mond, Joseph Poxon, Sophie Rabas, Germander Soothill, Marialuisa Zedde, Konstantin Yenkoyan, Bruce Brew, Erika Contini, Lucette Cysique, Xin Zhang, Pietro Maggi, Vincent van Pesch, Jérome Lechien, Sven Saussez, Alex Heyse, Maria Lúcia Brito Ferreira, Cristiane N. Soares, Isabel Elicer, Laura Eugenín-von Bernhardi, Waleng Ñancupil Reyes, Rong Yin, Mohammed A. Azab, Foad Abd-Allah, Ahmed Elkady, Simon Escalard, Jean-Christophe Corvol, Cécile Delorme, Pierre Tattevin, Kévin Bigaut, Norbert Lorenz, Daniel Hornuss, Jonas Hosp, Siegbert Rieg, Dirk Wagner, Benjamin Knier, Paul Lingor, Andrea Sylvia Winkler, Athena Sharifi-Razavi, Shima T. Moein, SeyedAhmad SeyedAlinaghi, Saeidreza JamaliMoghadamSiahkali, Mauro Morassi, Alessandro Padovani, Marcello Giunta, Ilenia Libri, Simone Beretta, Sabrina Ravaglia, Matteo Foschi, Paolo Calabresi, Guido Primiano, Serenella Servidei, Nicola Biagio Mercuri, Claudio Liguori, Mariangela Pierantozzi, Loredana Sarmati, Federica Boso, Silvia Garazzino, Sara Mariotto, Kimani N. Patrick, Oana Costache, Alexander Pincherle, Frederikus A. Klok, Roger Meza, Verónica Cabreira, Sofia R. Valdoleiros, Vanessa Oliveira, Igor Kaimovsky, Alla Guekht, Jasmine Koh, Eva Fernández Díaz, José María Barrios-López, Cristina Guijarro-Castro, Álvaro Beltrán-Corbellini, Javier Martínez-Poles, Alba María Diezma-Martín, Maria Isabel Morales-Casado, Sergio García García, Gautier Breville, Matteo Coen, Marjolaine Uginet, Raphaël Bernard-Valnet, Renaud Du Pasquier, Yildiz Kaya, Loay H. Abdelnour, Claire Rice, Hamish Morrison, Sylviane Defres, Saif Huda, Noelle Enright, Jane Hassell, Lucio D’Anna, Matthew Benger, Laszlo Sztriha, Eamon Raith, Krishna Chinthapalli, Ross Nortley, Ross Paterson, Arvind Chandratheva, David J. Werring, Samir Dervisevic, Kirsty Harkness, Ashwin Pinto, Dinesh Jillella, Scott Beach, Kulothungan Gunasekaran, Ivan Rocha Ferreira Da Silva, Krishna Nalleballe, Jonathan Santoro, Tyler Scullen, Lora Kahn, Carla Y. Kim, Kiran T. Thakur, Rajan Jain, Thirugnanam Umapathi, Timothy R. Nicholson, James J. Sejvar, Eva Maria Hodel, The Brain Infections Global COVID-Neuro Network Study Group, Catrin Tudur Smith, and Tom Solomon

Subjects
Medicine, Science
Abstract

Background Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome. Methods We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models. Results We included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67–82]), than encephalopathy (54% [42–65]). Intensive care use was high (38% [35–41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27–32]. The hazard of death was comparatively lower for patients in the WHO European region. Interpretation Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and stroke suggest different disease mechanisms which may be amenable to intervention, especially in those who develop neurological symptoms after hospital admission.

Published
2022

4. Enteral nutrition in patients with tumours of the head and neck

Author

Janvier Soler de la Mano, Juan José Verdaguer Martín, Julio Jesús Acero Sanz, Pilar Garcia Peris, Jose Maria Barrios Robredo, and Carlos Navarro Vila

Subjects
Adult, Male, medicine.medical_specialty, Fatal outcome, Leukocyte Count, Enteral Nutrition, Weight Loss, medicine, Humans, In patient, Lymphocytes, Head and neck, Serum Albumin, Aged, business.industry, General surgery, Body Weight, Transferrin, Nutritional status, Buccal administration, Middle Aged, medicine.disease, Surgery, Catheter, Malnutrition, Skinfold Thickness, Parenteral nutrition, Otorhinolaryngology, Head and Neck Neoplasms, Female, Oral Surgery, business, Energy Metabolism
Abstract

Summary An evaluation is presented of the nutritional status of 30 patients out of the 45 submitted to head and neck surgery, involving the buccal cavity, in the Maxillofacial Surgery Service of the General Hospital “Gregorio Maranon” of Madrid, between October 1985 and December 1986, before and after being submitted to excision of a tumour in the head or neck, by administration, in the postoperative period, of a liquid comprehensive diet via a nasogastric catheter. Neither in the postoperative period nor after stopping the enteral nutrition was the existence of malnutrition detected, in any of the parameters studied. One patient inhaled gastric juice with a fatal outcome, while the rest of the patients had no severe complications. Therefore, we think that the administration of enteral nutrition in this kind of patient is very useful and is indeed necessary to avoid energy-protein malnutrition during the postoperative period. At the same time it avoids possible infection by food remaining in the oral cavity.

Published
1989

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