10 results on '"Jose Manuel Lisbona-Montañez"'
Search Results
2. Adiposity is associated with expansion of the genus Dialister in rheumatoid arthritis patients
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Natalia Mena-Vázquez, Patricia Ruiz-Limón, Isabel Moreno-Indias, Sara Manrique-Arija, Jose Manuel Lisbona-Montañez, José Rioja, Arkaitz Mucientes, Gracia María Martin-Núñez, Laura Cano-García, Francisco J. Tinahones, and Antonio Fernández-Nebro
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Rheumatoid arthritis ,Gut microbiota ,Obesity ,Adiposity ,Body composition ,Inflammation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objective: To analyze the intestinal microbiota of patients with rheumatoid arthritis (RA) and obesity and a higher percentage of fatty tissue. Methods: Nested case-control study of 80 RA patients and 80 age and sex-matched controls. Obesity was defined as a body mass index ≥ 30, and body composition using dual-energy x-ray absorptiometry. The gut microbiota was analyzed using 16 S rRNA gene sequencing; bioinformatics analysis was performed using QIIME2 and PICRUSt. Other variables included averaged 28-joint Disease Activity Score (DAS28-ESR), cytokines and adipokines. Two multivariate were constructed with obesity and fat mass index (FMI). Results: Obesity was more frequent in RA patients than in controls (36.3 % vs 25.1 %; p = 0.026), as was a higher FMI value (mean [SE]=11.6 [3.9] vs 10.2 [3.9]; p = 0.032). Alpha and beta diversity analysis revealed differences in gut microbiota between RA patients with and without obesity. Dialister and Odoribacter were more abundant in RA patients with obesity than in RA patients without obesity, while the genus Clostridium was more abundant in RA patients without obesity. The factors associated with obesity in RA patients were age (OR [95 % CI], 1.09 [1.02–1.17]), mean DAS28-ESR (OR [95 % CI], 1.46 [1.12–1.67]), leptin levels (OR [95 % CI], 1.06 [1.01–1.10]), the genus Dialister (OR [95 % CI], 1.03 [1.01–1.07]), and the genus Clostridium (OR [95 % CI], 0.013 [0.00–0.36]). The associations observed for FMI were similar. Conclusions: In patients with RA, obesity, and a higher percentage of fatty tissue, intestinal microbiota differed from that of controls and of the other patients. The genus Dialister was associated with obesity and FMI.
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- 2023
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3. Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study
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Natalia Mena-Vázquez, Jose Manuel Lisbona-Montañez, Rocío Redondo-Rodriguez, Arkaitz Mucientes, Sara Manrique-Arija, José Rioja, Aimara Garcia-Studer, Fernando Ortiz-Márquez, Laura Cano-García, and Antonio Fernández-Nebro
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late-onset rheumatoid arthritis ,young-onset rheumatoid arthritis ,aging ,inflammation ,early rheumatoid arthritis ,Medicine (General) ,R5-920 - Abstract
ObjectivesTo describe the characteristics of patients between late-onset rheumatoid arthritis (LORA) with young-onset (YORA), and analyze their association with cumulative inflammatory burden.MethodsWe performed a nested cohort study in a prospective cohort comprising 110 patients with rheumatoid arthritis (RA) and 110 age- and sex-matched controls. The main variable was cumulative inflammatory activity according to the 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR). High activity was defined as DAS28 ≥ 3.2 and low activity as DAS28 < 3.2. The other variables recorded were inflammatory cytokines, physical function, and comorbid conditions. Two multivariate models were run to identify factors associated with cumulative inflammatory activity.ResultsA total of 22/110 patients (20%) met the criteria for LORA (≥ 60 years). Patients with LORA more frequently had comorbid conditions than patients with YORA and controls. Compared with YORA patients, more LORA patients had cumulative high inflammatory activity from onset [13 (59%) vs. 28 (31%); p = 0.018] and high values for CRP (p = 0.039) and IL-6 (p = 0.045). Cumulative high inflammatory activity in patients with RA was associated with LORA [OR (95% CI) 4.69 (1.49–10.71); p = 0.008], smoking [OR (95% CI) 2.07 (1.13–3.78); p = 0.017], anti–citrullinated peptide antibody [OR (95% CI) 3.24 (1.15–9.13); p = 0.025], average Health Assessment Questionnaire (HAQ) score [OR (95% CI) 2.09 (1.03–14.23); p = 0.034], and physical activity [OR (95% CI) 0.99 (0.99–0.99); p = 0.010]. The second model revealed similar associations with inflammatory activity in patients with LORA.ConclusionControl of inflammation after diagnosis is poorer and comorbidity more frequent in patients with LORA than in YORA patients and healthy controls.
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- 2022
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4. Collinsella is associated with cumulative inflammatory burden in an established rheumatoid arthritis cohort
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Patricia Ruiz-Limón, Natalia Mena-Vázquez, Isabel Moreno-Indias, Sara Manrique-Arija, Jose Manuel Lisbona-Montañez, Laura Cano-García, Francisco J. Tinahones, and Antonio Fernández-Nebro
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Gut microbiota ,Inflammation ,Rheumatoid arthritis ,Collinsella ,Cumulative inflammatory burden ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objective: To analyze the gut microbiota of patients with rheumatoid arthritis (RA) according to disease activity. Methods: An observational cross-sectional study of 110 patients with RA and 110 age- and sex-matched controls was performed. Patients were classified according to the disease activity (DAS28 ≥3.2 or DAS28
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- 2022
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5. Inflammatory Biomarkers in the Diagnosis and Prognosis of Rheumatoid Arthritis–Associated Interstitial Lung Disease
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Natalia Mena-Vázquez, Francisco Javier Godoy-Navarrete, Jose Manuel Lisbona-Montañez, Rocío Redondo-Rodriguez, Sara Manrique-Arija, José Rioja, Arkaitz Mucientes, Patricia Ruiz-Limón, Aimara Garcia-Studer, Fernando Ortiz-Márquez, Begoña Oliver-Martos, Laura Cano-García, and Antonio Fernández-Nebro
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rheumatoid arthritis ,interstitial lung disease ,biomarkers ,cytokines ,morbidity ,inflammation ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
This study aimed to identify inflammatory factors and soluble cytokines that act as biomarkers in the diagnosis and prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). We performed a nested prospective observational case–control study of patients with RA-ILD matched by sex, age, and time since the diagnosis of RA. All participants underwent pulmonary function testing and high-resolution computed tomography. ILD was defined according to the criteria of the American Thoracic Society/European Respiratory Society; the progression of lung disease was defined as the worsening of FVC > 10% or DLCO > 15%. Inflammation-related variables included the inflammatory activity measured using the DAS28-ESR and a multiplex cytokine assay. Two Cox regression models were run to identify factors associated with ILD and the progression of ILD. The study population comprised 70 patients: 35 patients with RA-ILD (cases) and 35 RA patients without ILD (controls). A greater percentage of cases had higher DAS28-ESR (p = 0.032) and HAQ values (p = 0.003). The variables associated with RA-ILD in the Cox regression analysis were disease activity (DAS28) (HR [95% CI], 2.47 [1.17–5.22]; p = 0.017) and high levels of ACPA (HR [95% CI], 2.90 [1.24–6.78]; p = 0.014), IL-18 in pg/mL (HR [95% CI], 1.06 [1.00–1.12]; p = 0.044), MCP-1/CCL2 in pg/mL (HR [95% CI], 1.03 [1.00–1.06]; p = 0.049), and SDF-1 in pg/mL (HR [95% CI], 1.00 [1.00–1.00]; p = 0.010). The only variable associated with the progression of ILD was IL-18 in pg/mL (HR [95% CI], 1.25 [1.07–1.46]; p = 0.004). Our data support that the inflammatory activity was higher in patients with RA-ILD than RA patients without ILD. Some cytokines were associated with both diagnosis and poorer prognosis in patients with RA-ILD.
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- 2023
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6. Longitudinal Study of Cognitive Functioning in Adults with Juvenile Idiopathic Arthritis
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Natalia Mena-Vázquez, Fernando Ortiz-Márquez, Pablo Cabezudo-García, Claudia Padilla-Leiva, Gisela Diaz-Cordovés Rego, Luis Muñoz-Becerra, Teresa Ramírez-García, Jose Manuel Lisbona-Montañez, Sara Manrique-Arija, Arkaitz Mucientes, Esmeralda Núñez-Cuadros, Rocío Galindo Zavala, Pedro Jesús Serrano-Castro, and Antonio Fernández-Nebro
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juvenile idiopathic arthritis ,cognitive functions ,inflammation ,biological therapy ,Biology (General) ,QH301-705.5 - Abstract
Objective: To prospectively evaluate possible decline of cognitive functions in adult patients with juvenile idiopathic arthritis (JIA) and identify associated factors. Patients and methods: We performed a 24-month prospective observational study of adults (≥16 years) with JIA. The primary outcome measure was decline in cognitive function defined as a worsening of ≥2 points on the scales of the subsets administered to evaluate the different cognitive areas using the Wechsler Adult Intelligence Scale (WAIS) after 24 months: attention/concentration (digit span); verbal function (vocabulary); visual-spatial organization (block design); working memory (letter-number sequencing); and problem solving (similarities). Other variables included average inflammatory activity using C-reactive protein and composite activity indexes, comorbidity, and treatment. Logistic regression was performed to identify factors associated with cognitive decline. Results: The study population comprised 52 patients with JIA. Of these, 15 (28.8%) had cognitive decline at V24. The most affected functions were working memory (17.3%), attention/concentration (9.6%), verbal function (7.7%), visual-spatial organization (7.7%), and problem solving (3.8%). There were no significant differences in the median direct or scale scores for the cognitive functions evaluated between V0 and V24 for the whole sample. The factors associated with cognitive decline in patients with JIA were average C-reactive protein (OR [95% CI], 1.377 [1.060–1.921]; p = 0.039), depression (OR [95% CI], 3.691 [1.294–10.534]; p = 0.015), and treatment with biologics (OR [95% CI], 0.188 [0.039–0.998]; p = 0.046). Conclusion: Cognitive decline was detected in almost one third of adults with JIA after 24 months of follow-up. Systemic inflammatory activity in JIA patients was related to cognitive decline. Patients treated with biologics had a lower risk of decline in cognitive functions.
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- 2022
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7. Postprandial Hyperlipidemia: Association with Inflammation and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
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Natalia Mena-Vázquez, Rocío Redondo-Rodríguez, José Rioja, Francisco Gabriel Jimenez-Nuñez, Sara Manrique-Arija, Jose Manuel Lisbona-Montañez, Laura Cano-García, Marta Rojas-Gimenez, Inmaculada Ureña, Pedro Valdivielso, and Antonio Fernández-Nebro
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rheumatoid arthritis ,postprandial lipemia ,triglycerides ,apolipoprotein B48 ,inflammation ,subclinical atherosclerosis ,Biology (General) ,QH301-705.5 - Abstract
Objective: To describe postprandial lipidemia in patients with rheumatoid arthritis (RA) and to analyze its association with subclinical atherosclerosis and inflammatory activity. Methods: Observational study of 80 cases of RA and 80 sex- and age-matched controls. We excluded individuals with dyslipidemia. Postprandial hyperlipidemia (PPHL) was defined as postprandial triglycerides >220 mg/dL and/or postprandial ApoB48 levels >75th percentile (>p75). Plasma lipids, cholesterol, triglycerides, ApoB48, and total ApoB were evaluated at baseline and after a meal. Other variables analyzed included subclinical atherosclerosis (defined as presence of carotid atheromatous plaque), inflammatory activity (disease activity score (DAS28-ESR)), cytokines, apolipoproteins, and physical activity. A multivariate analysis was performed to identify factors associated with PPHL in patients with RA. Results: A total of 75 patients with RA and 67 healthy controls fulfilled the inclusion criteria. PPHL was more frequent in patients with RA than controls (No. (%), 29 (38.70) vs. 15 (22.40); p = 0.036), as was subclinical atherosclerosis (No. (%), 22 (30.10) vs. 10 (14.90); p = 0.032). PPHL in patients with RA was associated with subclinical atherosclerosis (OR (95% CI) 4.69 (1.09–12.11); p = 0.037), TNF-α (OR (95% CI) 2.00 (1.00–3.98); p = 0.048), high-sensitivity C-reactive protein (OR (95% CI) 1.10 (1.01–1.19); p = 0.027), and baseline triglycerides (OR (95% CI) 1.02 (1.00–1.04); p = 0.049). Conclusion: PPHL was more frequent in patients with RA than in controls. PPHL in patients with RA was associated with inflammation and subclinical atherosclerosis.
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- 2022
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8. Importance of Vaccination against SARS-CoV-2 in Patients with Interstitial Lung Disease Associated with Systemic Autoimmune Disease
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Natalia Mena-Vázquez, Aimara García-Studer, Marta Rojas-Gimenez, Carmen María Romero-Barco, Sara Manrique-Arija, Arkaitz Mucientes, María Luisa Velloso-Feijoo, Francisco Javier Godoy-Navarrete, Pilar Morales-Garrido, Rocío Redondo-Rodríguez, MC Ordoñez-Cañizares, Rafaela Ortega-Castro, Jose Manuel Lisbona-Montañez, Ana Hidalgo Conde, Rocío Arnedo Díez de los Ríos, Eva Cabrera César, Francisco Espildora, María Carmen Aguilar-Hurtado, Isabel Añón-Oñate, Inmaculada Ureña-Garnica, and Antonio Fernández-Nebro
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vaccination COVID-19 ,interstitial lung disease (ILD) ,systemic autoimmune disease (SAD) ,General Medicine ,SARS-CoV-2 infections - Abstract
Objectives: To describe the frequency of COVID-19 and the effect of vaccination in patients with interstitial lung disease and systemic autoimmune disease (ILD-SAD) and to identify factors associated with infection and severity of COVID-19. Methods: We performed a cross-sectional multicenter study of patients with ILD-SAD followed between June and October 2021. The main variable was COVID-19 infection confirmed by a positive polymerase chain reaction (PCR) result for SARS-CoV-2. The secondary variables included severity of COVID-19, if the patient had to be admitted to hospital or died of the disease, and vaccination status. Other variables included clinical and treatment characteristics, pulmonary function and high-resolution computed tomography. Two logistic regression was performed to explore factors associated with “COVID-19” and “severe COVID-19”. Results: We included 176 patients with ILD-SAD: 105 (59.7%) had rheumatoid arthritis, 49 (27.8%) systemic sclerosis, and 22 (12.54%) inflammatory myopathies. We recorded 22/179 (12.5%) SARS-CoV-2 infections, 7/22 (31.8%) of them were severe and 3/22 (13.22%) died. As to the vaccination, 163/176 (92.6%) patients received the complete doses. The factors associated with SARS-CoV-2 infection were FVC (OR (95% CI), 0.971 (0.946–0.989); p = 0.040), vaccination (OR (95% CI), 0.169 (0.030–0.570); p = 0.004), and rituximab (OR (95% CI), 3.490 (1.129–6.100); p = 0.029). The factors associated with severe COVID-19 were the protective effect of the vaccine (OR (95% CI), 0.024 (0.004–0.170); p < 0.001) and diabetes mellitus (OR (95% CI), 4.923 (1.508–19.097); p = 0.018). Conclusions: Around 13% of patients with ILD-SAD had SARS-CoV-2 infection, which was severe in approximately one-third. Most patients with severe infection were not fully vaccinated.
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- 2022
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9. Intestinal Dysbiosis, Tight Junction Proteins, and Inflammation in Rheumatoid Arthritis Patients: A Cross-Sectional Study
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Arkaitz Mucientes, José Manuel Lisbona-Montañez, Natalia Mena-Vázquez, Patricia Ruiz-Limón, Sara Manrique-Arija, Aimara García-Studer, Fernando Ortiz-Márquez, and Antonio Fernández-Nebro
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tight junction proteins ,intestinal permeability ,gut microbiota ,rheumatoid arthritis ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Recent studies point to intestinal permeability as an important factor in the establishment and development of rheumatoid arthritis (RA). Tight junctions (TJs) play a major role in intestinal homeostasis. The alteration of this homeostasis is related to RA. Furthermore, RA patients present dysbiosis and a lower microbiota diversity compared to healthy individuals. A cross-sectional study including RA patients and sex- and age-matched healthy controls was performed. The quantification of TJ proteins was carried out by ELISA. Gut microbiota was evaluated by NGS platform Ion Torrent S. The inflammatory variables included were DAS28, CRP, inflammatory cytokines (IL-6, IL-1, TNF-α) and oxidised LDL. Claudin-1 levels showed significant differences between groups. Results evidenced a correlation between claudin-1 values and age (r: −0.293; p < 0.05), IL6 (r: −0.290; p < 0.05) and CRP (r: −0.327; p < 0.05), and between zonulin values and both age (r: 0.267; p < 0.05) and TNFα (r: 0.266; p < 0.05). Moreover, claudin-1 and CRP levels are related in RA patients (β: −0.619; p: 0.045), and in patients with high inflammatory activity, the abundance of the genus Veillonella is positively associated with claudin-1 levels (β: 39.000; p: 0.004).
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- 2024
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10. Linking serum vitamin D levels with gut microbiota after 1-year lifestyle intervention with Mediterranean diet in patients with obesity and metabolic syndrome: a nested cross-sectional and prospective study
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Hatim Boughanem, Patricia Ruiz-Limón, Jesús Pilo, José Manuel Lisbona-Montañez, Francisco J. Tinahones, Isabel Moreno Indias, and Manuel Macías-González
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25-hydroxyvitamin D ,obesity ,metabolic syndrome ,gut microbiota ,vitamin D ,MedDiet ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
ABSTRACTVitamin D, microbiota, and the Mediterranean diet (MedDiet) have been the focus of recent research due to their potential role in maintaining overall health. We hypothesize that MedDiet may alter the gut microbiota profile through changes in vitamin D levels. We aimed to investigate changes in gut microbiota and serum vitamin D levels after a MedDiet within a lifestyle intervention. The study included 91 patients with obesity and metabolic syndrome, who were categorized based on their serum vitamin D levels as having either optimal or low 25-hydroxyvitamin D [25(OH)D levels]. The profile of the gut microbiota was analyzed by the 16S rRNA sequencing, inferring its functionality through PICRUsT. Participants underwent a hypocaloric MedDiet and change in their lifestyle for 1 year, and the profile and functionality of their gut microbiota were evaluated by analyzing inter-individual differences in time. At baseline, gut microbiota profiles qualitatively differed between participants with Optimal or Low 25(OH)D levels [Unweighted (p = 0.016)]. Moreover, participants with Optimal 25(OH)D levels showed a higher gut microbiota diversity than those with Low 25(OH)D levels (p
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- 2023
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