503 results on '"José M. Menchón"'
Search Results
2. The role of neurotrophin genes involved in the vulnerability to gambling disorder
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Neus Solé-Morata, Isabel Baenas, Mikel Etxandi, Roser Granero, Sonia V. Forcales, Manel Gené, Carme Barrot, Mónica Gómez-Peña, José M. Menchón, Nicolás Ramoz, Philip Gorwood, Fernando Fernández-Aranda, and Susana Jiménez-Murcia
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Medicine ,Science - Abstract
Abstract Evidence about the involvement of genetic factors in the development of gambling disorder (GD) has been assessed. Among studies assessing heritability and biological vulnerability for GD, neurotrophin (NTF) genes have emerged as promising targets, since a growing literature showed a possible link between NTF and addiction-related disorders. Thus, we aimed to explore the role of NTF genes and GD with the hypothesis that some NTF gene polymorphisms could constitute biological risk factors. The sample included 166 patients with GD and 191 healthy controls. 36 single nucleotide polymorphisms (SNPs) from NTFs (NGF, NGFR, NTRK1, BDNF, NTRK2, NTF3, NTRK3, NTF4, CNTF and CNTFR) were selected and genotyped. Linkage disequilibrium (LD) and haplotype constructions were analyzed, in relationship with the presence of GD. Finally, regulatory elements overlapping the identified SNPs variants associated with GD were searched. The between groups comparisons of allele frequencies indicated that 6 SNPs were potentially associated with GD. Single and multiple-marker analyses showed a strong association between both NTF3 and NTRK2 genes, and GD. The present study supports the involvement of the NTF family in the aetiopathogenesis of GD. An altered cross-regulation of different NTF members signalling pathways might be considered as a biological vulnerability factor for GD.
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- 2022
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3. Treatment-resistant OCD: Pharmacotherapies in adults
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Peter J. van Roessel, Giacomo Grassi, Elias N. Aboujaoude, José M. Menchón, Michael Van Ameringen, and Carolyn I. Rodríguez
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OCD ,Treatment-resistant ,Pharmacotherapy ,Psychiatry ,RC435-571 - Abstract
Serotonin reuptake inhibitor (SRI) medications are well established as first-line pharmacotherapeutic treatment for Obsessive-Compulsive Disorder (OCD). However, despite the excellent safety profile and demonstrated efficacy of these medications, a substantial proportion of individuals with OCD fail to attain sufficient benefit from SRIs.In this narrative review, we discuss clinical features of OCD that have been associated with poorer response to SRIs, and we present pharmacotherapeutic interventions that have been explored as augmenting or alternative treatments for treatment-resistant OCD. We additionally highlight non-SRI interventions for OCD that are currently under investigation.Pharmacotherapeutic interventions were identified via expert consensus. To assess the evidence base for individual pharmacotherapies, targeted searches for relevant English-language publications were performed on standard biomedical research databases, including MEDLINE. Information relevant to ongoing registered clinical trials in OCD was obtained by search of ClinicalTrials.gov. Pharmacotherapies are grouped for review in accordance with the general principles of Neuroscience-based Nomenclature (NbN).Clinical features of OCD that may suggest poorer response to SRI treatment include early age of onset, severity of illness, duration of untreated illness, and the presence of symmetry/ordering or hoarding-related symptoms. Based on evolving pathophysiologic models of OCD, diverse agents engaging serotonin, dopamine, norepinephrine, glutamate, and anti-inflammatory pathways have been explored as alternative or adjunctive therapies for treatment-resistant OCD and have at least preliminary evidence of efficacy.Medications with dopamine antagonist activity remain the most robustly evidence-based of augmenting interventions, yet dopamine antagonists benefit only a minority of those who try them and carry elevated risks of adverse effects. Interventions targeting glutamatergic and anti-inflammatory pathways are less well evidenced, but may offer more favorable benefit to risk profiles. Ongoing research should explore whether specific interventions may benefit individuals with particular features of treatment-resistant OCD.
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- 2023
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4. Advances in problematic usage of the internet research – A narrative review by experts from the European network for problematic usage of the internet
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Naomi A. Fineberg, José M. Menchón, Natalie Hall, Bernardo Dell'Osso, Matthias Brand, Marc N. Potenza, Samuel R. Chamberlain, Giovanna Cirnigliaro, Christine Lochner, Joël Billieux, Zsolt Demetrovics, Hans Jürgen Rumpf, Astrid Müller, Jesús Castro-Calvo, Eric Hollander, Julius Burkauskas, Edna Grünblatt, Susanne Walitza, Ornella Corazza, Daniel L. King, Dan J. Stein, Jon E. Grant, Stefano Pallanti, Henrietta Bowden-Jones, Michael Van Ameringen, Konstantinos Ioannidis, Lior Carmi, Anna E. Goudriaan, Giovanni Martinotti, Célia M.D. Sales, Julia Jones, Biljiana Gjoneska, Orsolya Király, Beatrice Benatti, Matteo Vismara, Luca Pellegrini, Dario Conti, Ilaria Cataldo, Gianluigi M. Riva, Murat Yücel, Maèva Flayelle, Thomas Hall, Morgan Griffiths, and Joseph Zohar
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Problematic usage of the Internet ,Behavioral addiction ,Gaming disorder ,Covid-19 pandemic ,Impulsive ,Compulsive ,Psychiatry ,RC435-571 - Abstract
Global concern about problematic usage of the internet (PUI), and its public health and societal costs, continues to grow, sharpened in focus under the privations of the COVID-19 pandemic. This narrative review reports the expert opinions of members of the largest international network of researchers on PUI in the framework of the European Cooperation in Science and Technology (COST) Action (CA 16207), on the scientific progress made and the critical knowledge gaps remaining to be filled as the term of the Action reaches its conclusion.A key advance has been achieving consensus on the clinical definition of various forms of PUI. Based on the overarching public health principles of protecting individuals and the public from harm and promoting the highest attainable standard of health, the World Health Organisation has introduced several new structured diagnoses into the ICD-11, including gambling disorder, gaming disorder, compulsive sexual behaviour disorder, and other unspecified or specified disorders due to addictive behaviours, alongside naming online activity as a diagnostic specifier. These definitions provide for the first time a sound platform for developing systematic networked research into various forms of PUI at global scale. Progress has also been made in areas such as refining and simplifying some of the available assessment instruments, clarifying the underpinning brain-based and social determinants, and building more empirically based etiological models, as a basis for therapeutic intervention, alongside public engagement initiatives.However, important gaps in our knowledge remain to be tackled. Principal among these include a better understanding of the course and evolution of the PUI-related problems, across different age groups, genders and other specific vulnerable groups, reliable methods for early identification of individuals at risk (before PUI becomes disordered), efficacious preventative and therapeutic interventions and ethical health and social policy changes that adequately safeguard human digital rights. The paper concludes with recommendations for achievable research goals, based on longitudinal analysis of a large multinational cohort co-designed with public stakeholders.
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- 2022
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5. Sleep disturbances in obsessive-compulsive disorder: influence of depression symptoms and trait anxiety
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Cinto Segalàs, Javier Labad, Neus Salvat-Pujol, Eva Real, Pino Alonso, Sara Bertolín, Susana Jiménez-Murcia, Carles Soriano-Mas, Carmen Monasterio, José M. Menchón, and Virginia Soria
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Obsessive-compulsive disorder ,Sleep disorders ,Sleep quality ,Delayed sleep phase disorder ,Depression ,Trait anxiety ,Psychiatry ,RC435-571 - Abstract
Abstract Background Sleep disturbances have been reported in obsessive-compulsive disorder (OCD) patients, with heterogeneous results. The aim of our study was to assess sleep function in OCD and to investigate the relationship between sleep and the severity of obsessive-compulsive (OC) symptoms, depressive symptoms and trait anxiety. Methods Sleep quality was measured in 61 OCD patients and 100 healthy controls (HCs) using the Pittsburgh Sleep Quality Index (PSQI). Multiple linear regression was conducted to explore the association between sleep and psychopathological measures; a mediation analysis was also performed. Results OCD patients showed poor sleep quality and more sleep disturbances compared to HCs. The severity of depression, trait anxiety and OC symptomatology were correlated with poor sleep quality. Multiple linear regression analyses controlling for potential confounders revealed that the severity of depression and trait anxiety were independently related to poor sleep quality in OCD. A mediation analysis showed that both the severity of trait anxiety and depression mediate the relationship between the severity of OC symptoms and poor sleep quality among patients with OCD. Conclusions Our findings support the existence of sleep disturbances in OCD. Trait anxiety and depression play a key role in sleep quality among OCD patients.
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- 2021
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6. Problematic use of the internet during the COVID-19 pandemic: Good practices and mental health recommendations
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Biljana Gjoneska, Marc N. Potenza, Julia Jones, Ornella Corazza, Natalie Hall, Célia M.D. Sales, Edna Grünblatt, Giovanni Martinotti, Julius Burkauskas, Anna Maria Werling, Susanne Walitza, Joseph Zohar, José M. Menchón, Orsolya Király, Samuel R. Chamberlain, Naomi A. Fineberg, and Zsolt Demetrovics
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COVID-19 pandemic ,Addictive behaviors ,Problematic internet use ,Online gaming ,Online gambling ,Online pornography ,Psychiatry ,RC435-571 - Abstract
With the onset of the COVID-19 pandemic and the accelerated spread of the SARS-CoV-2 virus came jurisdictional limitations on mobility of citizens and distinct alterations in their daily routines. Confined to their homes, many people increased their overall internet use, with problematic use of the internet (PUI) becoming a potential reason for increased mental health concerns. Our narrative review summarizes information on the extent of PUI during the pandemic, by focusing on three types: online gaming, gambling and pornography viewing. We conclude by providing guidance for mental health professionals and those affected by PUI (with an outline of immediate research priorities and best therapeutic approaches), as well as for the general public (with an overview of safe and preventative practices).
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- 2022
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7. Does Confinement Affect Treatment Dropout Rates in Patients With Gambling Disorder? A Nine-Month Observational Study
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Isabel Baenas, Mikel Etxandi, Ester Codina, Roser Granero, Fernando Fernández-Aranda, Mónica Gómez-Peña, Laura Moragas, Sandra Rivas, Marc N. Potenza, Anders Håkansson, Amparo del Pino-Gutiérrez, Bernat Mora-Maltas, Eduardo Valenciano-Mendoza, José M. Menchón, and Susana Jiménez-Murcia
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COVID-19 ,confinement ,gambling disorder ,dropout ,coping ,Psychology ,BF1-990 - Abstract
Background and Aims: COVID-19 pandemic and confinement have represented a challenge for patients with gambling disorder (GD). Regarding treatment outcome, dropout may have been influenced by these adverse circumstances. The aims of this study were: (a) to analyze treatment dropout rates in patients with GD throughout two periods: during and after the lockdown and (b) to assess clinical features that could represent vulnerability factors for treatment dropout.Methods: The sample consisted of n=86 adults, mostly men (n=79, 91.9%) and with a mean age of 45years old (SD=16.85). Patients were diagnosed with GD according to DSM-5 criteria and were undergoing therapy at a Behavioral Addiction Unit when confinement started. Clinical data were collected through a semi-structured interview and protocolized psychometric assessment. A brief telephone survey related to COVID-19 concerns was also administered at the beginning of the lockdown. Dropout data were evaluated at two moments throughout a nine-month observational period (T1: during the lockdown, and T2: after the lockdown).Results: The risk of dropout during the complete observational period was R=32/86=0.372 (37.2%), the Incidence Density Rate (IDR) ratio T2/T1 being equal to 0.052/0.033=1.60 (p=0.252). Shorter treatment duration (p=0.007), lower anxiety (p=0.025), depressive symptoms (p=0.045) and lower use of adaptive coping strategies (p=0.046) characterized patients who abandoned treatment during the lockdown. Briefer duration of treatment (p=0.001) and higher employment concerns (p=0.044) were highlighted in the individuals who dropped out after the lockdown. Treatment duration was a predictor of dropout in both periods (p=0.005 and p
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- 2021
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8. Biomarcadores de estrés transdiagnósticos en salud mental: polimorfismos genéticos en FKBP5 y regulación del eje hipotálamopituitarioadrenal en el trastorno depresivo mayor y en el trastorno obsesivo compulsivo.
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Alex Ferrera, Javier Costas, Javier Labad, Neus Salvat-Pujol, Cinto Segalàs, Mikel Urretavizcaya, Eva Reala, Aida De Arriba-Arnau, Pino Alonso, José M. Crespo, Marta Barrachina, Carles Soriano-Masa, Ángel Carracedo, José M. Menchón, and Virginia Soria
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Trastorno depresivo mayor ,Trastorno obsesivo compulsivo ,Estrés ,Eje hipotálamo-pituitario-adrenal ,FKBP5 ,Psychology ,BF1-990 ,Psychiatry ,RC435-571 - Published
- 2021
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9. e-Estesia: A Serious Game for Reducing Arousal, Improving Emotional Regulation and Increasing Wellbeing in Individuals with Gambling Disorder
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Teresa Mena-Moreno, Lucero Munguía, Roser Granero, Ignacio Lucas, Fernando Fernández-Aranda, Mónica Gómez-Peña, Laura Moragas, Antonio Verdejo-García, José M. Menchón, and Susana Jiménez-Murcia
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treatment outcomes ,emotion regulation ,complementary intervention ,serious games ,gambling disorder ,Medicine - Abstract
Gambling disorder (GD) is associated with deficits in emotion regulation and impulsivity-related personality traits. In recent years there has been an increase in the use of serious games (SG) to address these factors with positive results. The aim of this study was to analyze the efficacy of the intervention with a new SG (e-Estesia), as an adjunct to a CBT intervention for GD. The sample comprised two groups (experimental group (n = 40) and control group (n = 64)) of patients with GD diagnosis. Both groups received 16 weekly CBT sessions and, concurrently, only the experimental group received 15 additional sessions with e-Estesia. Pre-post treatment with e-Estesia administered in both groups were: DSM-5 Criteria, South Oaks Gambling Screen, Symptom Checklist-Revised and measure of relapses, dropout and compliance of treatment. As regards the experimental group were also administered: Difficulties in Emotion Regulation Scale, Emotion Regulation Questionnaire, and Impulsive Behavior Scale. No statistically significant differences in the general psychopathological state, emotion regulation or impulsivity were found when comparing the groups. However, patients enrolled in the e-Estesia intervention had significantly less relapses and better indicators of treatment compliance than the control group. Considering these results, the use of complementary tools such as SG are useful for addressing GD.
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- 2022
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10. Exploring the Association between Gambling-Related Offenses, Substance Use, Psychiatric Comorbidities, and Treatment Outcome
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Cristina Vintró-Alcaraz, Gemma Mestre-Bach, Roser Granero, Elena Caravaca, Mónica Gómez-Peña, Laura Moragas, Isabel Baenas, Amparo del Pino-Gutiérrez, Susana Valero-Solís, Milagros Lara-Huallipe, Bernat Mora-Maltas, Eduardo Valenciano-Mendoza, Elías Guillen-Guzmán, Ester Codina, José M. Menchón, Fernando Fernández-Aranda, and Susana Jiménez-Murcia
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gambling disorder ,gambling-related offenses ,dropout ,relapse ,psychopathology ,personality ,Medicine - Abstract
Several studies have explored the association between gambling disorder (GD) and gambling-related crimes. However, it is still unclear how the commission of these offenses influences treatment outcomes. In this longitudinal study we sought: (1) to explore sociodemographic and clinical differences (e.g., psychiatric comorbidities) between individuals with GD who had committed gambling-related illegal acts (differentiating into those who had had legal consequences (n = 31) and those who had not (n = 55)), and patients with GD who had not committed crimes (n = 85); and (2) to compare the treatment outcome of these three groups, considering dropouts and relapses. Several sociodemographic and clinical variables were assessed, including the presence of substance use, and comorbid mental disorders. Patients received 16 sessions of cognitive-behavioral therapy. Patients who reported an absence of gambling-related illegal behavior were older, and showed the lowest GD severity, the most functional psychopathological state, the lowest impulsivity levels, and a more adaptive personality profile. Patients who had committed offenses with legal consequences presented the highest risk of dropout and relapses, higher number of psychological symptoms, higher likelihood of any other mental disorders, and greater prevalence of tobacco and illegal drugs use. Our findings uphold that patients who have committed gambling-related offenses show a more complex clinical profile that may interfere with their adherence to treatment.
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- 2022
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11. A Serious Game to Improve Emotion Regulation in Treatment-Seeking Individuals With Gambling Disorder: A Usability Study
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Teresa Mena-Moreno, Fernando Fernández-Aranda, Roser Granero, Lucero Munguía, Trevor Steward, Hibai López-González, Amparo del Pino-Gutiérrez, María Lozano-Madrid, Mónica Gómez-Peña, Laura Moragas, Isabelle Giroux, Marie Grall-Bronnec, Anne Sauvaget, Bernat Mora-Maltas, Eduardo Valenciano-Mendoza, José M. Menchón, and Susana Jiménez-Murcia
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new technologies ,serious games ,heart rate variability ,emotion regulation ,gambling disorder ,Psychology ,BF1-990 - Abstract
Background: Serious games have shown positive results in increasing motivation, adherence to treatment and strengthening the therapeutic alliance in multiple psychiatric disorders. In particular, patients with impulse control disorders and other disorders in which the patient suffers from inhibitory control deficits (e.g., behavioral addictions) have been shown to benefit from serious games.Aim: The aim of this study was to describe the characteristics and to evaluate the usability of a new serious videogame, e-Estesia. This serious videogame was designed to improve emotion regulation in patients with gambling disorder (GD). Preliminary results from a pilot sample are also reported.Method: A pilot sample of 26 patients undergoing treatment for GD was recruited (ranging from 22 to 74 years, mean = 41.2 and SD = 12.9; 80.8% men). Participants used e-Estesia on a tablet, which was connected to a thoracic band that sent heart rate (HR) and heart rate variability (HRV) data to the videogame platform in order to provide biofeedback. The System Usability Scale was completed by patients to determine the usability of e-Estesia.Results and Discussion: e-Estesia performed comparatively well for all the explored groups (i.e., sex, age, and online vs. offline gambling: mean usability score = 83.8, SD = 13.1). Around 84.6% of the patients endorsed that it was easy to use. Female patients with GD presented higher HRV during the use of the serious videogame compared to men.
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- 2021
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12. An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder
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Víctor De la Peña-Arteaga, Mercedes Berruga-Sánchez, Trevor Steward, Ignacio Martínez-Zalacaín, Ximena Goldberg, Agustina Wainsztein, Carolina Abulafia, Narcís Cardoner, Mariana N. Castro, Mirta Villarreal, José M. Menchón, Salvador M. Guinjoan, and Carles Soriano-Mas
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Borderline personality disorder ,emotion regulation ,fMRI ,major depressive disorder ,neuroimaging ,Psychiatry ,RC435-571 - Abstract
Abstract Background One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations. Methods We contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n = 19), MDD patients (n = 20), and healthy controls (HCs; n = 19). Emotion regulation was assessed using an established functional magnetic resonance imaging cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity. Results When compared to HCs, patients with BPD and MDD displayed homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. In addition, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal. Conclusions This study identified, for the first time, a shared neurobiological contributor to emotion regulation deficits in MDD and BPD characterized by decreased vlPFC activity, although we also observed disorder-specific alterations. In MDD, results suggest a primary deficit in the strength of prefrontal activations, while BPD is better defined by connectivity disruptions between the vlPFC and temporal emotion processing regions. These findings substantiate, in neurobiological terms, the different profiles of emotion regulation alterations observed in these disorders.
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- 2021
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13. Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
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Neus Salvat-Pujol, Javier Labad, Mikel Urretavizcaya, Aida de Arriba-Arnau, Cinto Segalàs, Eva Real, Alex Ferrer, José M. Crespo, Susana Jiménez-Murcia, Carles Soriano-Mas, José M. Menchón, and Virginia Soria
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childhood abuse ,childhood neglect ,cortisol ,hpa axis ,dexamethasone suppression test ,cognition ,memory ,major depression ,Psychiatry ,RC435-571 - Abstract
Background: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods: Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results: Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions: HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects.
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- 2021
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14. Delay Discounting in Gambling Disorder: Implications in Treatment Outcome
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Teresa Mena-Moreno, Giulia Testa, Gemma Mestre-Bach, Romina Miranda-Olivos, Rosario Granero, Fernando Fernández-Aranda, José M. Menchón, and Susana Jiménez-Murcia
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impulsivity ,delay discounting ,gambling disorder ,treatment outcomes ,gambling preferences ,Medicine - Abstract
Impulsive choice, measured by delay discounting (DD) tasks, has been shown in patients with gambling disorders (GD). However, the impact of DD and treatment outcome has been scarcely explored in GD patients. The aims of this study were: (1) to examine the baseline association between DD and clinical variables in GD patients depending on their age and gambling preferences (strategic vs. non-strategic); and (2) to estimate the predictive role of DD on poorer outcomes of cognitive-behavioral therapy (CBT) when considering also the effect of other clinical variables. 133 treatment-seeking male GD patients were evaluated at baseline with a DD task and measures of GD severity, personality traits and psychopathology. Treatment outcome was measured in terms of dropout from CBT and relapses. Results showed baseline associations between DD and GD severity (correlation coefficient R = 0.408 among strategic gamblers and R = 0.279 among mixed gamblers) and between DD and positive/negative urgency (R = 0.330 for the youngest patients, R = 0.244 for middle age, and around R = 0.35 for gamblers who reported preferences for strategic games). Other personality traits such as high harm avoidance and low cooperativeness were also related to DD at baseline (R = 0.606 among strategic gamblers). Regarding treatment outcome, a steeper discount rate predicted a higher risk of relapses in strategic gamblers (odds ratio OR = 3.01) and middle-age ones (OR = 1.59), and a higher risk of dropout in younger gamblers (OR = 1.89), non-strategic gamblers (OR = 1.70) and mixed gamblers (R = 4.74). GD severity mediated the associations between age, DD, personality traits and poor CBT outcome. In conclusion, impulsive choice affects treatment response in individuals with GD and may interfere with it to a significant extent. Considering DD in GD, patients seeking treatment could help control its impact on treatment adherence and relapses.
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- 2022
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15. Gambling Phenotypes in Online Sports Betting
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Roser Granero, Susana Jiménez-Murcia, Amparo del Pino-Gutiérrez, Bernat Mora, Eduardo Mendoza-Valenciano, Isabel Baenas-Soto, Mónica Gómez-Peña, Laura Moragas, Ester Codina, Hibai López-González, Teresa Mena-Moreno, Gemma Mestre-Bach, Susana Valero-Solís, Sandra Rivas, Zaida Agüera, Cristina Vintró-Alcaraz, María Lozano-Madrid, José M. Menchón, and Fernando Fernández-Aranda
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clustering ,gambling disorder ,internet ,online sports betting ,phenotype ,Psychiatry ,RC435-571 - Abstract
Background and ObjectivesThe Internet provides easy access to multiple types of gambling and has led to changes in betting habits. A severe rise in problematic gambling has been predicted among all sectors of the population, and studies are required to assess the emerging phenotypes related to the new structures of gambling activities. This study aimed to explore the existence of latent classes associated with gambling habits among treatment-seeking gamblers due to Online Sports Betting (OSB).MethodInitial sample included n = 4,516 patients consecutively admitted for treatment in a hospital unit specialized in behavioral addictions. Two-step clustering analysis was used within the subsample of n = 323 patients who reported problems related with OSB, within a set of indicators including sociodemographics, psychopathological distress, personality, and severity of the gambling activity.ResultsThe prevalence of OSB as a main type of gambling problem in the study was 7.2% (95% confidence interval: 6.4 to 7.9%). Two latent clusters were identified, with differences in sociodemographics and clinical status. Cluster 1 (n = 247, 76.5%) grouped patients that were more affected due to the OSB behaviors, and it was characterized by non-married patients, lower socioeconomic position index, higher comorbidity with other substance related addictions, younger age, and early onset of the gambling activity, as well as higher debts due to the OSB, higher psychopathological distress, and a more dysfunctional personality profile. Cluster 2 (n = 76, 23.5%) grouped patients that were less affected by OSB, mostly married (or living with a stable partner), with higher social position levels, older age and older onset of the gambling activity, as well as a more functional psychopathological and personality profile.ConclusionThe increasing understanding of latent classes underlying OSB phenotypes is essential in guiding the development of reliable screening tools to identify individuals highly vulnerable to addictive behaviors among Internet gamblers, as well as in planning prevention and treatment initiatives focused on the precise profiles of these patients.
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- 2020
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16. Locus coeruleus connectivity alterations in late-life major depressive disorder during a visual oddball task
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Inés del Cerro, Ignacio Martínez-Zalacaín, Andrés Guinea-Izquierdo, Jordi Gascón-Bayarri, Vanesa Viñas-Diez, Mikel Urretavizcaya, Pablo Naval-Baudin, Carlos Aguilera, Ramón Reñé-Ramírez, Isidre Ferrer, José M. Menchón, Virginia Soria, and Carles Soriano-Mas
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Late-life major depressive disorder ,Mild cognitive impairment ,Locus coeruleus ,Anterior cingulate cortex ,Functional magnetic resonance imaging ,Visual oddball task ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
The Locus Coeruleus (LC) is the major source of noradrenergic neurotransmission. Structural alterations in the LC have been observed in neurodegenerative disorders and at-risk individuals, although functional connectivity studies between the LC and other brain areas have not been yet performed in these populations. Patients with late-life major depressive disorder (MDD) are indeed at increased risk for neurodegenerative disorders, and here we investigated LC connectivity in late-life MDD in comparison to individuals with amnestic type mild cognitive impairment (aMCI) and healthy controls (HCs). We assessed 20 patients with late-life MDD, 16 patients with aMCI, and 26 HCs, who underwent a functional magnetic resonance scan while performing a visual oddball task. We assessed task-related modulations of LC connectivity (i.e., Psychophysiological Interactions, PPI) with other brain areas. A T1-weighted fast spin-echo sequence for LC localization was also obtained. Patients with late-life MDD showed lower global connectivity during target detection in a cluster encompassing the right caudal LC. Specifically, we observed lower LC connectivity with the left anterior cingulate cortex (ACC), the right fusiform gyrus, and different cerebellar clusters. Moreover, alterations in LC-ACC connectivity correlated negatively with depression severity (i.e., Geriatric Depression Scale and number of recurrences). Reduced connectivity of the LC during oddball performance seems to specifically characterize patients with late-life MDD, but not other populations of aged individuals with cognitive alterations. Such alteration is associated with different measures of disease severity, such as the current presence of symptoms and the burden of disease (number of recurrences).
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- 2020
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17. Can the Addition of Maintenance Electroconvulsive Therapy to Pharmacotherapy Improve Relapse Prevention in Severe Major Depressive Disorder? A Randomized Controlled Trial
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Erika Martínez-Amorós, Narcís Cardoner, Verònica Gálvez, Aida de Arriba-Arnau, Virginia Soria, Diego J. Palao, José M. Menchón, and Mikel Urretavizcaya
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electroconvulsive therapy ,major depressive disorder ,prevention ,relapse ,recurrence ,maintenance ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Few systematic evaluations have been performed of the efficacy of electroconvulsive therapy (ECT) as a relapse prevention strategy in major depressive disorder (MDD). This is a single-blind, multicenter, randomized controlled trial to compare the efficacy and tolerability of pharmacotherapy plus maintenance ECT (M-Pharm/ECT) versus pharmacotherapy alone (M-Pharm) in the prevention of MDD relapse. Subjects with MDD who had remitted with bilateral acute ECT (n = 37) were randomly assigned to receive M-Pharm/ECT (n = 19, 14 treatments) or M-Pharm (n = 18) for nine months. The subjects were followed up for 15 months. The main outcome was relapse of depression, defined as a score of 18 or more on the Hamilton Depression Rating Scale. At nine months, 35% of the subjects treated with M-Pharm/ECT relapsed as compared with 61% of the patients treated with M-Pharm. No statistically significant differences between groups were indicated by either Kaplan–Meier or Cox proportional hazards regression analyses. The subjects without psychotic features were at higher risk of relapse. There were no statistically significant differences in the MMSE scores of the two groups at the end of the study. Further studies are needed to better define the indications for M-ECT in order to improve its efficacy as a relapse prevention strategy.
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- 2021
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18. Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders
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Zaida Agüera, Cristina Vintró-Alcaraz, Isabel Baenas, Roser Granero, Isabel Sánchez, Jéssica Sánchez-González, José M. Menchón, Susana Jiménez-Murcia, Janet Treasure, and Fernando Fernández-Aranda
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body mass index (BMI) profiles ,eating disorders ,obesity ,treatment outcome ,Nutrition. Foods and food supply ,TX341-641 - Abstract
The association between lifetime weight fluctuations and clinical characteristics has been widely studied in populations with eating disorders (ED). However, there is a lack of literature examining the potential role of weight course as a transdiagnostic factor in ED so far. Therefore, the aim of this study is to compare ED severity and treatment outcomes among four specific BMI profiles based on BMI-trajectories across the lifespan: (a) persistent obesity (OB-OB; (n = 74)), (b) obesity in the past but currently in a normal weight range (OB-NW; n = 156), (c) normal weight throughout the lifespan (NW-NW; n = 756), and (d) current obesity but previously at normal weight (NW-OB; n = 314). Lifetime obesity is associated with greater general psychopathology and personality traits such as low persistence and self-directedness, and high reward dependence. Additionally, greater extreme weight changes (NW-OB and OB-NW) were associated with higher psychopathology but not with greater ED severity. Higher dropout rates were found in the OB-OB group. These results shed new light on the BMI trajectory as a transdiagnostic feature playing a pivotal role in the severity and treatment outcome in patients with ED.
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- 2021
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19. Efficacy of prospective pharmacogenetic testing in the treatment of major depressive disorder: results of a randomized, double-blind clinical trial
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Víctor Pérez, Ariana Salavert, Jordi Espadaler, Miquel Tuson, Jerónimo Saiz-Ruiz, Cristina Sáez-Navarro, Julio Bobes, Enrique Baca-García, Eduard Vieta, José M. Olivares, Roberto Rodriguez-Jimenez, José M. Villagrán, Josep Gascón, Josep Cañete-Crespillo, Montse Solé, Pilar A. Saiz, Ángela Ibáñez, Javier de Diego-Adeliño, AB-GEN Collaborative Group, and José M. Menchón
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Depression ,Pharmacogenetics ,Precision medicine ,Antidepressant response ,Randomized clinical trial ,Psychiatry ,RC435-571 - Abstract
Abstract Background A 12-week, double-blind, parallel, multi-center randomized controlled trial in 316 adult patients with major depressive disorder (MDD) was conducted to evaluate the effectiveness of pharmacogenetic (PGx) testing for drug therapy guidance. Methods Patients with a CGI-S ≥ 4 and requiring antidepressant medication de novo or changes in their medication regime were recruited at 18 Spanish public hospitals, genotyped with a commercial PGx panel (Neuropharmagen®), and randomized to PGx-guided treatment (n = 155) or treatment as usual (TAU, control group, n = 161), using a computer-generated random list that locked or unlocked psychiatrist access to the results of the PGx panel depending on group allocation. The primary endpoint was the proportion of patients achieving a sustained response (Patient Global Impression of Improvement, PGI-I ≤ 2) within the 12-week follow-up. Patients and interviewers collecting the PGI-I ratings were blinded to group allocation. Between-group differences were evaluated using χ2-test or t-test, as per data type. Results Two hundred eighty patients were available for analysis at the end of the 12-week follow-up (PGx n = 136, TAU n = 144). A difference in sustained response within the study period (primary outcome) was not observed (38.5% vs 34.4%, p = 0.4735; OR = 1.19 [95%CI 0.74-1.92]), but the PGx-guided treatment group had a higher responder rate compared to TAU at 12 weeks (47.8% vs 36.1%, p = 0.0476; OR = 1.62 [95%CI 1.00-2.61]), and this difference increased after removing subjects in the PGx-guided group when clinicians explicitly reported not to follow the test recommendations (51.3% vs 36.1%, p = 0.0135; OR = 1.86 [95%CI 1.13-3.05]). Effects were more consistent in patients with 1–3 failed drug trials. In subjects reporting side effects burden at baseline, odds of achieving a better tolerability (Frequency, Intensity and Burden of Side Effects Rating Burden subscore ≤2) were higher in the PGx-guided group than in controls at 6 weeks and maintained at 12 weeks (68.5% vs 51.4%, p = 0.0260; OR = 2.06 [95%CI 1.09-3.89]). Conclusions PGx-guided treatment resulted in significant improvement of MDD patient’s response at 12 weeks, dependent on the number of previously failed medication trials, but not on sustained response during the study period. Burden of side effects was also significantly reduced. Trial registration European Clinical Trials Database 2013-002228-18 , registration date September 16, 2013; ClinicalTrials.gov NCT02529462 , retrospectively registered: August 19, 2015.
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- 2017
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20. Corrigendum: Phenotypes in Gambling Disorder Using Sociodemographic and Clinical Clustering Analysis: An Unidentified New Subtype?
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Susana Jiménez-Murcia, Roser Granero, Fernando Fernández-Aranda, Randy Stinchfield, Joel Tremblay, Trevor Steward, Gemma Mestre-Bach, María Lozano-Madrid, Teresa Mena-Moreno, Núria Mallorquí-Bagué, José C. Perales, Juan F. Navas, Carles Soriano-Mas, Neus Aymamí, Mónica Gómez-Peña, Zaida Agüera, Amparo del Pino-Gutiérrez, Virginia Martín-Romera, and José M. Menchón
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gambling disorder ,clustering ,personality traits ,psychopathology ,severity ,Psychiatry ,RC435-571 - Published
- 2019
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21. 10Kin1day: A Bottom-Up Neuroimaging Initiative
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Martijn P. van den Heuvel, Lianne H. Scholtens, Hannelore K. van der Burgh, Federica Agosta, Clara Alloza, Celso Arango, Bonnie Auyeung, Simon Baron-Cohen, Silvia Basaia, Manon J. N. L. Benders, Frauke Beyer, Linda Booij, Kees P. J. Braun, Geraldo Busatto Filho, Wiepke Cahn, Dara M. Cannon, Tiffany M. Chaim-Avancini, Sandra S. M. Chan, Eric Y. H. Chen, Benedicto Crespo-Facorro, Eveline A. Crone, Udo Dannlowski, Sonja M. C. de Zwarte, Bruno Dietsche, Gary Donohoe, Stefan Du Plessis, Sarah Durston, Covadonga M. Díaz-Caneja, Ana M. Díaz-Zuluaga, Robin Emsley, Massimo Filippi, Thomas Frodl, Martin Gorges, Beata Graff, Dominik Grotegerd, Dariusz Gąsecki, Julie M. Hall, Laurena Holleran, Rosemary Holt, Helene J. Hopman, Andreas Jansen, Joost Janssen, Krzysztof Jodzio, Lutz Jäncke, Vasiliy G. Kaleda, Jan Kassubek, Shahrzad Kharabian Masouleh, Tilo Kircher, Martijn G. J. C. Koevoets, Vladimir S. Kostic, Axel Krug, Stephen M. Lawrie, Irina S. Lebedeva, Edwin H. M. Lee, Tristram A. Lett, Simon J. G. Lewis, Franziskus Liem, Michael V. Lombardo, Carlos Lopez-Jaramillo, Daniel S. Margulies, Sebastian Markett, Paulo Marques, Ignacio Martínez-Zalacaín, Colm McDonald, Andrew M. McIntosh, Genevieve McPhilemy, Susanne L. Meinert, José M. Menchón, Christian Montag, Pedro S. Moreira, Pedro Morgado, David O. Mothersill, Susan Mérillat, Hans-Peter Müller, Leila Nabulsi, Pablo Najt, Krzysztof Narkiewicz, Patrycja Naumczyk, Bob Oranje, Victor Ortiz-Garcia de la Foz, Jiska S. Peper, Julian A. Pineda, Paul E. Rasser, Ronny Redlich, Jonathan Repple, Martin Reuter, Pedro G. P. Rosa, Amber N. V. Ruigrok, Agnieszka Sabisz, Ulrich Schall, Soraya Seedat, Mauricio H. Serpa, Stavros Skouras, Carles Soriano-Mas, Nuno Sousa, Edyta Szurowska, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Sofie L. Valk, Leonard H. van den Berg, Theo G. M. van Erp, Neeltje E. M. van Haren, Judith M. C. van Leeuwen, Arno Villringer, Christiaan H. Vinkers, Christian Vollmar, Lea Waller, Henrik Walter, Heather C. Whalley, Marta Witkowska, A. Veronica Witte, Marcus V. Zanetti, Rui Zhang, and Siemon C. de Lange
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MRI ,connectome analysis ,diffusion weighted MRI ,brain ,network ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain.
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- 2019
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22. A Comparison of DSM-IV-TR and DSM-5 Diagnostic Criteria for Gambling Disorder in a Large Clinical Sample
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Susana Jiménez-Murcia, Roser Granero, Fernando Fernández-Aranda, Anne Sauvaget, Andreas Fransson, Anders Hakansson, Gemma Mestre-Bach, Trevor Steward, Randy Stinchfield, Laura Moragas, Neus Aymamí, Mónica Gómez-Peña, Amparo del Pino-Gutiérrez, Zaida Agüera, Marta Baño, Maria-Teresa Talón-Navarro, Àngel Cuquerella, Ester Codina, and José M. Menchón
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DSM-IV-TR ,DSM-5 ,gambling disorder ,criminal behaviors ,severity ,personality ,Psychology ,BF1-990 - Abstract
Background and Aims: Gambling-related crimes are known to be associated with gambling disorder (GD). Due to a lack of consensus in the scientific community regarding the relevance of this diagnostic criterion, it was removed from the DSM-5. The primary aim of this study was to investigate through structural equation modeling (SEM) whether higher GD severity in treatment-seeking GD patients with a criminal record is mediated through the illegal acts criterion itself, or whether it can be better explained by other related clinical factors.Methods: An initial sample of 2,081 patients seeking treatment for gambling problems was included in the sample. SEM was used to evaluate the mediational role of the illegal acts criterion between the sex, age and personality traits, gambling severity, and comorbid depression levels. Comparisons between patients with coinciding and divergent DSM criterion for GD diagnosis were carried out.Results: Illegal acts mediated the relationship between personality traits and GD severity: younger age, high levels of novelty seeking, and low levels of self-transcendence increased the risk of endorsing the illegal acts criterion. No differences between coincident-divergent groups in terms of DSM-IV and DSM-5 diagnosis were found with regards to sex (p = 0.878), education level (p = 0.387), or civil status (p = 0.792).Discussion and Conclusion: The results obtained in the present study offer new insights into the utility of using a history of illegal acts, their different personality characteristics, and psychopathology to categorize GD patients. Our findings suggest that patients who engage in criminal behavior may require a more comprehensive intervention.
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- 2019
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23. Phenotypes in Gambling Disorder Using Sociodemographic and Clinical Clustering Analysis: An Unidentified New Subtype?
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Susana Jiménez-Murcia, Roser Granero, Fernando Fernández-Aranda, Randy Stinchfield, Joel Tremblay, Trevor Steward, Gemma Mestre-Bach, María Lozano-Madrid, Teresa Mena-Moreno, Núria Mallorquí-Bagué, José C. Perales, Juan F. Navas, Carles Soriano-Mas, Neus Aymamí, Mónica Gómez-Peña, Zaida Agüera, Amparo del Pino-Gutiérrez, Virginia Martín-Romera, and José M. Menchón
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gambling disorder ,clustering ,personality traits ,psychopathology ,severity ,Psychiatry ,RC435-571 - Abstract
Background: Gambling disorder (GD) is a heterogeneous disorder which has clinical manifestations that vary according to variables in each individual. Considering the importance of the application of specific therapeutic interventions, it is essential to obtain clinical classifications based on differentiated phenotypes for patients diagnosed with GD.Objectives: To identify gambling profiles in a large clinical sample of n = 2,570 patients seeking treatment for GD.Methods: An agglomerative hierarchical clustering method defining a combination of the Schwarz Bayesian Information Criterion and log-likelihood was used, considering a large set of variables including sociodemographic, gambling, psychopathological, and personality measures as indicators.Results: Three-mutually-exclusive groups were obtained. Cluster 1 (n = 908 participants, 35.5%), labeled as “high emotional distress,” included the oldest patients with the longest illness duration, the highest GD severity, and the most severe levels of psychopathology. Cluster 2 (n = 1,555, 60.5%), labeled as “mild emotional distress,” included patients with the lowest levels of GD severity and the lowest levels of psychopathology. Cluster 3 (n = 107, 4.2%), labeled as “moderate emotional distress,” included the youngest patients with the shortest illness duration, the highest level of education and moderate levels of psychopathology.Conclusion: In this study, the general psychopathological state obtained the highest importance for clustering.
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- 2019
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24. An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group
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Premika S. W. Boedhoe, Martijn W. Heymans, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D. Feusner, Kate D. Fitzgerald, Jean-Paul Fouche, Egill A. Fridgeirsson, Patricia Gruner, Gregory L. Hanna, Derrek P. Hibar, Marcelo Q. Hoexter, Hao Hu, Chaim Huyser, Neda Jahanshad, Anthony James, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lazaro, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M. Menchón, Luciano Minuzzi, Astrid Morer, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Seiji Nishida, Erika L. Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y. C. Janardhan Reddy, Tim J. Reess, Yuki Sakai, Joao R. Sato, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C. Stevens, Philip R. Szeszko, David F. Tolin, Guido A. van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Je-Yeon Yun, ENIGMA-OCD Working-Group, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, and Jos W. R. Twisk
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neuroimaging ,MRI ,IPD meta-analysis ,mega-analysis ,linear mixed-effect models ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses.Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods.Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models.Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data.
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- 2019
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25. The Contribution of Sex, Personality Traits, Age of Onset and Disorder Duration to Behavioral Addictions
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Susana Valero-Solís, Roser Granero, Fernando Fernández-Aranda, Trevor Steward, Gemma Mestre-Bach, Núria Mallorquí-Bagué, Virginia Martín-Romera, Neus Aymamí, Mónica Gómez-Peña, Amparo del Pino-Gutiérrez, Marta Baño, Laura Moragas, José M. Menchón, and Susana Jiménez-Murcia
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behavioral addictions ,compulsive buying ,internet gambling disorder ,gambling disorder ,sex addiction ,age ,Psychiatry ,RC435-571 - Abstract
Background and aims: Increases in the prevalence of behavioral addictions worldwide have led to a growth in the etiological research of the specific contribution of risk/protective factors to these disorders. The objective of this study was to assess the relative role of patients' sex, age of disorder onset and disorder duration on the clinical profile of behavioral addictions.Methods: Our sample included treatment-seeking patients diagnosed with gambling disorder (GD, n = 3,174), internet gambling disorder (IGD, n = 45), compulsive buying (CB, n = 113), and sex addiction (SA, n = 34).Results: The pattern of associations between the independent variables and the outcomes were strongly related to the behavioral addiction subtype: (a) for GD-men early onset of the disorder was related to GD severity, while for GD-women early onset was linked to novelty seeking; (b) for IGD-men, late onset correlated with addiction severity, worse psychopathological state, and high harm avoidance and self-transcendence levels; (c) for CB-women, early onset was related to higher reward-dependence scores and lower self-transcendence levels, and longer duration predicted higher cumulate debts; for CB-men, early onset and long duration correlated with high scores in harm-avoidance, self-directedness, self-transcendence, and cooperativeness; and (d) for SA-men, late onset and longer duration correlated with high disorder severity.Discussion and Conclusions: These findings are relevant for developing prevention and treatment programs specific to different behavioral addictions.
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- 2018
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26. Corrigendum: Validation of the Spanish Version of the Yale Food Addiction Scale 2.0 (YFAS 2.0) and Clinical Correlates in a Sample of Eating Disorder, Gambling Disorder and Healthy Control Participants
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Roser Granero, Susana Jiménez-Murcia, Ashley N. Gearhardt, Zaida Agüera, Neus Aymamí, Mónica Gómez-Peña, María Lozano-Madrid, Núria Mallorquí-Bagué, Gemma Mestre-Bach, Maria I. Neto-Antao, Nadine Riesco, Isabel Sánchez, Trevor Steward, Carles Soriano-Mas, Cristina Vintró-Alcaraz, José M. Menchón, Felipe F. Casanueva, Carlos Diéguez, and Fernando Fernández-Aranda
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eating disorders ,food addiction ,gambling disorder ,psychometric properties ,validation ,YFAS 2.0 ,Psychiatry ,RC435-571 - Published
- 2018
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27. Validation of the Spanish Version of the Yale Food Addiction Scale 2.0 (YFAS 2.0) and Clinical Correlates in a Sample of Eating Disorder, Gambling Disorder, and Healthy Control Participants
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Roser Granero, Susana Jiménez-Murcia, Ashley N. Gearhardt, Zaida Agüera, Neus Aymamí, Mónica Gómez-Peña, María Lozano-Madrid, Núria Mallorquí-Bagué, Gemma Mestre-Bach, Maria I. Neto-Antao, Nadine Riesco, Isabel Sánchez, Trevor Steward, Carles Soriano-Mas, Cristina Vintró-Alcaraz, José M. Menchón, Felipe F. Casanueva, Carlos Diéguez, and Fernando Fernández-Aranda
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eating disorders ,food addiction ,gambling disorder ,psychometric properties ,validation ,YFAS 2.0 ,Psychiatry ,RC435-571 - Abstract
Aims: Due to the increasing evidence of shared vulnerabilities between addictive behaviors and excessive food intake, the concept of food addiction in specific clinical populations has become a topic of scientific interest. The aim of this study was to validate the Yale Food Addiction Scale (YFAS) 2.0 in a Spanish sample. We also sought to explore food addiction and its clinical correlates in eating disorder (ED) and gambling disorder (GD) patients.Methods: The sample included 301 clinical cases (135 ED and 166 GD), diagnosed according to DSM-5 criteria, and 152 healthy controls (HC) recruited from the general population.Results: Food addiction was more prevalent in patients with ED, than in patients with GD and HC (77.8, 7.8, and 3.3%, respectively). Food addiction severity was associated with higher BMI, psychopathology and specific personality traits, such as higher harm avoidance, and lower self-directedness. The psychometrical properties of the Spanish version of the YFAS 2.0 were excellent with good convergent validity. Moreover, it obtained good accuracy in discriminating between diagnostic subtypes.Conclusions: Our results provide empirical support for the use of the Spanish YFAS 2.0 as a reliable and valid tool to assess food addiction among several clinical populations (namely ED and GD). The prevalence of food addiction is heterogeneous between disorders. Common risk factors such as high levels of psychopathology and low self-directedness appear to be present in individuals with food addiction.
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- 2018
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28. A Comparison of Treatment-Seeking Behavioral Addiction Patients with and without Parkinson’s Disease
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Anne Sauvaget, Susana Jiménez-Murcia, Fernando Fernández-Aranda, Roser Granero, Marie Grall-Bronnec, Caroline Victorri-Vigneau, Samuel Bulteau, Pascal Derkinderen, Jean M. Vanelle, Anders Hakansson, Gemma Mestre-Bach, Trevor Steward, and José M. Menchón
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Parkinson’s disease ,personality ,impulsivity ,behavioral addictions ,gambling disorder ,impulse control disorders ,Psychiatry ,RC435-571 - Abstract
The administration of dopaminergic medication to treat the symptoms of Parkinson’s disease (PD) is associated with addictive behaviors and impulse control disorders. Little is known, however, on how PD patients differ from other patients seeking treatments for behavioral addictions. The aim of this study was to compare the characteristics of behavioral addiction patients with and without PD. N = 2,460 treatment-seeking men diagnosed with a behavioral addiction were recruited from a university hospital. Sociodemographic, impulsivity [Barratt Impulsiveness Scale (BIS-11)], and personality [Temperament and Character Inventory-Revised (TCI-R)] measures were taken upon admission to outpatient treatment. Patients in the PD group were older and had a higher prevalence of mood disorders than patients without PD. In terms of personality characteristics and impulsivity traits, PD patients appeared to present a more functional profile than PD-free patients with a behavioral addiction. Our results suggest that PD patients with a behavioral addiction could be more difficult to detect than their PD-free counterparts in behavioral addiction clinical setting due to their reduced levels of impulsivity and more standard personality traits. As a whole, this suggests that PD patients with a behavioral addiction may have different needs from PD-free behavioral addiction patients and that they could potentially benefit from targeted interventions.
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- 2017
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29. Diurnal variation of heart rate variability as a physiological index of mood and emotion regulation processes in Major Depression and Borderline Personality Disorder
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Wainsztein, Agustina E., Abulafia, Carolina, Goldberg, Ximena, Camacho-Téllez, Vicente, Vulcano, Mercedes, Vigo, Daniel E., José M., Menchón, Soriano-Mas, Carles, Nemeroff, Charles B., Salvador M., Guinjoan, and Castro, Mariana N.
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- 2020
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30. Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
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Iliyan Ivanov, Premika S.W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Srinivas Balachander, Justin T. Baker, Nerisa Banaj, Nuria Bargalló, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Juliana B. Diniz, Benjamin A. Ely, Jamie D. Feusner, Sónia Ferreira, Kate D. Fitzgerald, Martine Fontaine, Patricia Gruner, Gregory L. Hanna, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Keisuke Ikari, Anthony James, Fern Jaspers-Fayer, Hongyan Jiang, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Jun Soo Kwon, Luisa Lázaro, Yanni Liu, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M. Menchón, Luciano Minuzzi, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Sanghoon Oh, Chris Perriello, John C. Piacentini, Maria Picó-Pérez, Fabrizio Piras, Federica Piras, Y.C. Janardhan Reddy, Daniela Rodriguez Manrique, Yuki Sakai, Eiji Shimizu, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, David F. Tolin, Daan van Rooij, Dick J. Veltman, Ysbrand D. van der Werf, Guido A. van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je-Yeon Yun, Mojtaba Zarei, Fengrui Zhang, Qing Zhao, Neda Jahanshad, Sophia I. Thomopoulos, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Joseph O'Neill, Sara Poletti, Egill Axfjord Fridgeirsson, Toshikazu Ikuta, Stella J. de Wit, Chris Vriend, Selina Kasprzak, Masaru Kuno, Jumpei Takahashi, Euripedes C. Miguel, Roseli G. Shavitt, Morgan Hough, Jose C. Pariente, Ana E. Ortiz, Sara Bertolín, Eva Real, Cinto Segalàs, Pedro Silva Moreira, Nuno Sousa, Jin Narumoto, Kei Yamada, Jinsong Tang, Jean-Paul Fouche, Taekwan Kim, Sunah Choi, Minji Ha, Sunghyun Park, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Systems & Network Neuroscience, Amsterdam Neuroscience - Neurodegeneration, Adult Psychiatry, Child Psychiatry, Paediatric Psychosocial Care, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Graduate School, Ivanov, Iliyan, Boedhoe, Premika S W, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Arnold, Paul D, Balachander, Sriniva, Baker, Justin T, Banaj, Nerisa, Bargalló, Nuria, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Brem, Silvia, Brennan, Brian P, Buitelaar, Jan, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Dallaspezia, Sara, Denys, Damiaan, Diniz, Juliana B, Ely, Benjamin A, Feusner, Jamie D, Ferreira, Sónia, Fitzgerald, Kate D, Fontaine, Martine, Gruner, Patricia, Hanna, Gregory L, Hirano, Yoshiyuki, Hoexter, Marcelo Q, Huyser, Chaim, Ikari, Keisuke, James, Anthony, Jaspers-Fayer, Fern, Jiang, Hongyan, Kathmann, Norbert, Kaufmann, Christian, Kim, Minah, Koch, Kathrin, Kwon, Jun Soo, Lázaro, Luisa, Liu, Yanni, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Morer, Astrid, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, Oh, Sanghoon, Perriello, Chri, Piacentini, John C, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Reddy, Y C Janardhan, Manrique, Daniela Rodriguez, Sakai, Yuki, Shimizu, Eiji, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carle, Spalletta, Gianfranco, Stern, Emily R, Stevens, Michael C, Stewart, S Evelyn, Szeszko, Philip R, Tolin, David F, van Rooij, Daan, Veltman, Dick J, van der Werf, Ysbrand D, van Wingen, Guido A, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Watanabe, Anri, Wolters, Lidewij H, Xu, Xiufeng, Yun, Je-Yeon, Zarei, Mojtaba, Zhang, Fengrui, Zhao, Qing, Jahanshad, Neda, Thomopoulos, Sophia I, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and O'Neill, Joseph
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Obsessive-Compulsive Disorder ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,OCD ,Psychotropics ,Longevity ,SRIs ,Magnetic Resonance Imaging ,Benzodiazepines ,Psychiatry and Mental health ,Clinical Psychology ,Age ,Cross-Sectional Studies ,Subcortical volumes ,130 000 Cognitive Neurology & Memory ,Child, Preschool ,Serotonin Uptake Inhibitors ,Humans ,Child ,Selective Serotonin Reuptake Inhibitors ,Aged ,Antipsychotic Agents - Abstract
Background: Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs. Methods: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6–65) was divided into six successive 6–10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients. Results: Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6–13 and adults aged 50–65 with OCD taking SRIs (Cohen's d = −0.24 to −0.74). Volumes of putamen, pallidum (d = 0.18–0.40), and ventricles (d = 0.31–0.66) were greater in patients aged 20–29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = −0.27 to −1.31). Conclusions: Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20–29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.
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- 2022
31. Hippocampal and amygdala subfield volumes in obsessive-compulsive disorder differ according to medication status
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Ziphozihle Ntwatwa, Christine Lochner, Annerine Roos, Tatum Sevenoaks, Jack van Honk, Pino Alonso, Marcelo C. Batistuzzo, Sunah Choi, Marcelo Q. Hoexter, Minah Kim, Jun S. Kwon, David Mataix-Cols, José M. Menchón, Euripides C. Miguel, Takashi Nakamae, Mary L. Phillips, Carles Soriano-Mas, Dick J. Veltman, Nynke A. Groenewold, Odile A. van den Heuvel, Dan J. Stein, and Jonathan Ipser
- Abstract
IntroAlthough it has been suggested that the hippocampus and amygdala (HA) are involved in the neurobiology of obsessive-compulsive disorder (OCD), volumetric findings have been inconsistent. Furthermore, the HA consist of heterogenous anatomic units with specific functions and cytoarchitecture, and little work has been undertaken on the volumetry of these subfields in OCD.MethodsT1-weighted images from 381 patients with OCD and 338 healthy controls (HCs) from the OCD Brain Imaging Consortium were segmented to produce twelve hippocampal subfields and nine amygdala subfields using FreeSurfer 6.0. We assessed between-group differences in subfield volume using a mixed-effects model adjusted for age, quadratic effects of age, sex, site, and whole HA volume. Given evidence of confounding effects of clinical characteristics on brain volumes in OCD, we also performed subgroup analyses to examine subfield volume in relation to comorbid anxiety and depression, medication status, and symptom severity.ResultsPatients with OCD and HCs did not significantly differ in HA subfield volume. However, medicated patients with OCD had significantly smaller hippocampal dentate gyrus (pFDR=0.042,d=-0.26) and molecular layer (pFDR=0.042, d=-0.29) and larger lateral (pFDR=0.049,d=0.23) and basal (pFDR=0.049,d=0.25) amygdala subfields than HCs. Unmedicated patients had significantly smaller hippocampal CA1 (pFDR=0.016, d=-0.28) than HCs. No association was detected between any subfield volume and OCD severity.ConclusionDifferences in HA subfields between OCD and HCs are dependent on medication status, in line with previous work on other brain volumetric alterations in OCD. This emphasizes the importance of considering psychotropic medication in neuroimaging studies of OCD.
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- 2023
32. Cortical thickness across the lifespan
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Simon E. Fisher, Eveline A. Crone, Dominik Grotegerd, Jilly Naaijen, Anders M. Dale, Sean N. Hatton, Ramona Baur-Streubel, Anthony A. James, Daniel Brandeis, Andrew J. Kalnin, Andreas Reif, Hans-Jörgen Grabe, Pieter J. Hoekstra, Lars Nyberg, Fleur M. Howells, Moji Aghajani, Randy L. Buckner, Daniel A. Rinker, Steven G. Potkin, Dennis van 't Ent, Rachel M. Brouwer, Sophia Frangou, Yang Wang, Nhat Trung Doan, Theodore D. Satterthwaite, Christine Lochner, Geraldo F. Busatto, Lars T. Westlye, Lara M. Wierenga, Calhoun Vd, Henry Brodaty, Carles Soriano-Mas, Annette Conzelmann, Christian K. Tamnes, Julian N. Trollor, Nicholas G. Martin, Neeltje E.M. van Haren, René S. Kahn, Irina Lebedeva, Philip Asherson, Suzanne C. Swagerman, John A. Joska, Theophilus N. Akudjedu, Kang Sim, Lachlan T. Strike, Patricia Gruner, Brenna C. McDonald, Thomas Frodl, Edith Pomarol-Clotet, Víctor Ortiz-García de la Foz, Margaret J. Wright, Norbert Hosten, Jean-Paul Fouche, Bernd Weber, Salvador Sarró, Wei Wen, Dag Alnæs, Greig I. de Zubicaray, Iris E. C. Sommer, Marise W. J. Machielsen, Knut Schnell, Dara M. Cannon, Paola Fuentes-Claramonte, Josiane Bourque, Andreas Meyer-Lindenberg, Anton Albajes-Eizagirre, Sarah Hohmann, Erin W. Dickie, Theo G.M. van Erp, Micael Andersson, Paul Pauli, Thomas Espeseth, Heather C. Whalley, Victoria Chubar, Ruben C. Gur, Tomohiro Nakao, Xavier Caseras, Alessandro Bertolino, Ignacio Martínez-Zalacaín, Katharina Wittfeld, Erick J. Canales-Rodríguez, David C. Glahn, Neda Jahanshad, Jiyang Jiang, Katie L. McMahon, Stefan Borgwardt, Erlend S. Dørum, Jaap Oosterlaan, Won Hee Lee, Alan Breier, Steven Williams, Aristotle N. Voineskos, Bernard Mazoyer, Jordan W. Smoller, Nancy C. Andreasen, Ilya M. Veer, Tiffany M. Chaim-Avancini, Sophie Maingault, Paul M. Thompson, Eco J. C. de Geus, Luisa Lázaro, Giulio Pergola, Efstathios Papachristou, Beng-Choon Ho, David Mataix-Cols, Esther Walton, Ben J. Harrison, Dirk J. Heslenfeld, Pablo Najt, Helena Fatouros-Bergman, Derrek P. Hibar, Gunter Schumann, Raymond Salvador, Lieuwe de Haan, Henry Völzke, Joaquim Radua, Henk Temmingh, Lianne Schmaal, Martine Hoogman, Daniel H. Wolf, Georg C. Ziegler, Marieke Klein, Barbara Franke, Erik G. Jönsson, Laura Koenders, Stefan Ehrlich, Oliver Gruber, Ingrid Agartz, Kun Yang, Ryota Kanai, Sarah Baumeister, Colm McDonald, Annabella Di Giorgio, Amanda Worker, Anne Uhlmann, Marcus V. Zanetti, Danai Dima, Matthew D. Sacchet, Sarah E. Medland, Aurora Bonvino, Benedicto Crespo-Facorro, Jan Egil Nordvik, Joshua L. Roffman, Yannis Paloyelis, Jessica A. Turner, T. P. Klyushnik, Christopher G. Davey, Rachel E. Gur, Ian B. Hickie, Christopher R.K. Ching, Jonna Kuntsi, Tobias Banaschewski, Chaim Huyser, Amirhossein Modabbernia, John D. West, Fabrice Crivello, Núria Bargalló, Patricia J. Conrod, Nic J.A. van der Wee, Mauricio H. Serpa, Thomas H. Wassink, Kathryn I. Alpert, Dick J. Veltman, Andrew J. Saykin, Genevieve McPhilemy, Perminder S. Sachdev, Vincent P. Clark, Ian H. Gotlib, Susanne Erk, Henrik Walter, Dennis van den Meer, Simon Cervenka, Oliver Grimm, Andrew M. McIntosh, Alexander Tomyshev, Francisco X. Castellanos, Bernd Kramer, Klaus-Peter Lesch, Odile A. van den Heuvel, Sophia I. Thomopoulos, Diana Tordesillas-Gutiérrez, Terry L. Jernigan, Yulyia Yoncheva, Anouk den Braber, Jim Lagopoulos, Maria J. Portella, Ole A. Andreassen, Gaelle E. Doucet, Avram J. Holmes, Nynke A. Groenewold, Pedro G.P. Rosa, Hilleke E. Hulshoff Pol, Sanne Koops, José M. Menchón, Jan K. Buitelaar, Dan J. Stein, Dorret I. Boomsma, Lei Wang, C.A. Hartman, Pascual Sánchez-Juan, Andreas Heinz, European Commission, National Institute of Child Health and Human Development (US), QIMR Berghofer Medical Research Institute (Australia), University of Queensland, National Cancer Institute (US), Dutch Research Council, Netherlands Organisation for Health Research and Development, National Institute of Mental Health (US), European Research Council, National Center for Advancing Translational Sciences (US), Medical Research Council (UK), Fundación Marques de Valdecilla, Instituto de Salud Carlos III, Swedish Research Council, South-Eastern Norway Regional Health Authority, Research Council of Norway, Icahn School of Medicine at Mount Sinai, South London and Maudsley NHS Foundation Trust, NHS Foundation Trust, National Institute for Health Research (UK), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Movement Disorder (MD), Developmental Neuroscience in Society, Child and Adolescent Psychiatry / Psychology, Adult Psychiatry, APH - Mental Health, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Child Psychiatry, ANS - Cellular & Molecular Mechanisms, General Paediatrics, ARD - Amsterdam Reproduction and Development, Karolinska Schizophrenia Project (KaSP), Ontwikkelingspsychologie (Psychologie, FMG), Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Epidemiology and Data Science, Neurology, Amsterdam Neuroscience - Neurodegeneration, Pediatric surgery, Anatomy and neurosciences, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Brain Imaging, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, Biological Psychology, APH - Methodology, Complex Trait Genetics, Amsterdam Neuroscience - Complex Trait Genetics, Educational and Family Studies, Cognitive Psychology, IBBA, Clinical Neuropsychology, Faculty of Behavioural and Movement Sciences, and APH - Personalized Medicine
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Male ,Aging ,Neurologi ,Audiology ,Trajectories ,0302 clinical medicine ,130 000 Cognitive Neurology & Memory ,diagnostic imaging [Cerebral Cortex] ,Child ,Research Articles ,Cerebral Cortex ,Psychiatry ,Aged, 80 and over ,Radiological and Ultrasound Technology ,Fractional polynomial ,05 social sciences ,Radiology, Nuclear Medicine & Medical Imaging ,1. No poverty ,Cognition ,Middle Aged ,Cerebral cortex ,Regression ,3. Good health ,Escorça cerebral ,Neurology ,Radiology Nuclear Medicine and imaging ,Healthy individuals ,Child, Preschool ,anatomy & histology [Cerebral Cortex] ,Female ,Analysis of variance ,Anatomy ,Life Sciences & Biomedicine ,Trajectorie ,Research Article ,Neuroinformatics ,Adult ,medicine.medical_specialty ,Adolescent ,Human Development ,Clinical Neurology ,BF ,Neuroimaging ,Biology ,Development ,050105 experimental psychology ,Psykiatri ,Cortical thickness ,03 medical and health sciences ,Young Adult ,Neuroimaging genetics ,Envelliment ,medicine ,Humans ,trajectories ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,ddc:610 ,development ,Aged ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Science & Technology ,Brain morphometry ,aging ,Neurosciences ,cortical thickness ,Cross-Sectional Studies ,RC0321 ,Neurology (clinical) ,Neurosciences & Neurology ,030217 neurology & neurosurgery ,physiology [Human Development] - Abstract
Special Issue: The ENIGMA Consortium: the first 10 years., Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes., European Community's Seventh Framework Programme, Grant/Award Numbers: 278948, 602450, 603016, 602805; US National Institute of Child Health and Human Development, Grant/Award Numbers: RO1HD050735, 1009064, 496682; QIMR Berghofer Medical Research Institute and the Centre for Advanced Imaging, University of Queensland; ICTSI NIH/NCRR, Grant/Award Number: RR025761; European Community's Horizon 2020 Programme, Grant/Award Numbers: 667302, 643051; Vici Innovation Program, Grant/Award Numbers: #91619115, 016-130-669; NWO Brain & Cognition Excellence Program, Grant/Award Number: 433-09-229; Biobanking and Biomolecular Resources Research Infrastructure (Netherlands) (BBMRI-NL); Spinozapremie, Grant/Award Number: NWO-56-464-14192; Biobanking and Biomolecular Resources Research Infrastructure, Grant/Award Numbers: 184.033.111, 184.021.007; Netherlands Organization for Health Research and Development (ZonMW), Grant/Award Numbers: 480-15-001/674, 024.001.003, 911-09-032, 056-32-010, 481-08-011, 016-115-035, 31160008, 400-07-080, 400-05-717, 451-04-034, 463-06-001, 480-04-004, 904-61-193, 912-10-020, 985-10-002, 904-61-090; NIMH, Grant/Award Number: R01 MH090553; Geestkracht programme of the Dutch Health Research Council, Grant/Award Number: 10-000-1001; FP7 Ideas: European Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Grant/Award Numbers: NWO/SPI 56-464-14192, NWO-MagW 480-04-004, 433-09-220, NWO 51.02.062, NWO 51.02.061; National Center for Advancing Translational Sciences, National Institutes of Health, Grant/Award Number: UL1 TR000153; National Center for Research Resources; National Center for Research Resources at the National Institutes of Health, Grant/Award Numbers: NIH 1U24 RR025736-01, NIH 1U24 RR021992; NIH Institutes contributing to the Big Data to Knowledge; U.S. National Institutes of Health, Grant/Award Numbers: R01 CA101318, P30 AG10133, R01 AG19771; Medical Research Council, Grant/Award Numbers: U54EB020403, G0500092; National Institute of Mental Health, Grant/Award Numbers: R01MH117014, R01MH042191; Fundación Instituto de Investigación Marqués de Valdecilla, Grant/Award Numbers: API07/011, NCT02534363, NCT0235832; Instituto de Salud Carlos III, Grant/Award Numbers: PI14/00918, PI14/00639, PI060507, PI050427, PI020499; Swedish Research Council, Grant/Award Numbers: 523-2014-3467, 2017-00949, 521-2014-3487; South-Eastern Norway Health Authority; the Research Council of Norway, Grant/Award Number: 223273; South Eastern Norway Regional Health Authority, Grant/Award Numbers: 2017-112, 2019107; Icahn School of Medicine at Mount Sinai; Seventh Framework Programme (FP7/2007-2013), Grant/Award Number: 602450; National Institutes of Health, Grant/Award Numbers: R01 MH116147, R01 MH113619, R01 MH104284; South London and Maudsley NHS Foundation Trust; the National Institute for Health Research (NIHR)
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- 2022
33. Greater male than female variability in regional brain structure across the lifespan
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Erick J. Canales-Rodríguez, Hans J. Grabe, Dirk J. Heslenfeld, Erik G. Jönsson, Oliver Gruber, Daniel Brandeis, Yang Wang, Henry Brodaty, Ruben C. Gur, Iris E. C. Sommer, Paul M. Thompson, Knut K. Kolskår, Christopher G. Davey, Dick J. Veltman, Eco J. C. de Geus, Tobias Banaschewski, Greig I. Zubicaray, Xavier Caseras, Sarah Baumeister, Raquel E. Gur, Vincent P. Clark, Maria J. Portella, Simon E. Fisher, Christopher R.K. Ching, Lars T. Westlye, Laura Koenders, Vince D. Calhoun, Carles Soriano-Mas, Nicholas G. Martin, Stefan Ehrlich, Fleur M. Howells, Catharina A. Hartman, Matthew D. Sacchet, Ole A. Andreassen, Josiane Bourque, Fabrice Crivello, Annette Conzelmann, Jaap Oosterlaan, Brenna C. McDonald, Gaelle E. Doucet, Avram J. Holmes, José M. Menchón, Danai Dima, Moji Aghajani, Joshua L. Roffman, Steven Williams, Lei Wang, David Mataix-Cols, Philip R. Szeszko, Bernd Weber, Tiril P. Gurholt, Sarah Hohmann, Ian H. Gotlib, Patricia Gruner, Anthony C. James, Paul Pauli, Lara M. Wierenga, Andrew M. McIntosh, Andrew J. Kalnin, Jim Lagopoulos, Henrik Walter, Andreas Reif, Andrew Simmons, Norbert Hosten, Pieter J. Hoekstra, Aristotle Voineskos, Alexander Tomyshev, Anton Albajes-Eizagirre, Jean-Paul Fouche, Dara M. Cannon, Ignacio Martínez‐Zalacaín, Geneviève Richard, Theophilus N. Akudjedu, David C. Glahn, Patricia J. Conrod, Ben J. Harrison, Alan Anticevic, Martine Hoogman, Francisco X. Castellanos, Bernd Kramer, Neda Jahanshad, Lieuwe de Haan, Dennis van der Meer, John D. West, Alan Breier, Jordan W. Smoller, P. G. P. Rosa, Katharina Wittfeld, Dan J. Stein, Jiyang Jiang, Jilly Naaijen, Christine Lochner, Dorret I. Boomsma, Alessandro Bertolino, Marise W. J. Machielsen, Hilleke E. Hulshoff Pol, Henry Völzke, Christian K. Tamnes, Ingrid Agartz, Georg C. Ziegler, Marieke Klein, Lars Nyberg, Perminder S. Sachdev, Philip Asherson, I.M. Veer, Sean N. Hatton, Núria Bargalló, Annabella Di Giorgio, Henk Temmingh, John A. Joska, Odile A. van den Heuvel, Wei Wen, Eveline A Crone, Kang Sim, Kathryn I. Alpert, Dennis van 't Ent, Jan K. Buitelaar, Joaquim Radua, Julian N. Trollor, B Mazoyer, Chaim Huyser, H. C. Whalley, Irina Lebedeva, Erin W. Dickie, Marcus Vinicus Zanetti, Stefan Borgwardt, Theodore D. Satterthwaite, Daniel H Wolf, Sophia I. Thomopoulos, Giulio Pergola, Luisa Lazaro, Ramona Baur-Streubel, Beathe Haatveit, Yannis Paloyelis, Ian B. Hickie, Jonna Kuntsi, Sophia Frangou, R. Salvador, Geraldo F. Busatto, Margaret J. Wright, Aurora Bonvino, Edith Pomarol-Clotet, Anouk den Braber, Lachlan T. Strike, Phil Lee, Anne Uhlmann, Yuliya N. Yoncheva, Mauricio H. Serpa, Dag Alnæs, Paola Fuentes-Claramonte, Katie L. McMahon, Andrew J. Saykin, Genevieve McPhilemy, Tiffany M. Chaim-Avancini, Sophie Maingault, Barbara Franke, Colm McDonald, Rachel M. Brouwer, Salvador Sarró, Department of Psychology, Education and Child Studies, Biological Psychology, APH - Mental Health, APH - Methodology, Complex Trait Genetics, Amsterdam Neuroscience - Complex Trait Genetics, AMS - Ageing & Vitality, AMS - Sports, APH - Personalized Medicine, Cognitive Psychology, Clinical Neuropsychology, IBBA, Karolinska Schizophrenia Project (KaSP) Consortium, Adult Psychiatry, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Child Psychiatry, ANS - Cellular & Molecular Mechanisms, ANS - Amsterdam Neuroscience, General Paediatrics, ARD - Amsterdam Reproduction and Development, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Movement Disorder (MD), Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Neurology, Amsterdam Neuroscience - Neurodegeneration, Anatomy and neurosciences, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Pediatric surgery, and Amsterdam Neuroscience - Brain Imaging
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Male ,Netherlands Twin Register (NTR) ,SEGMENTATION ,Vulnerability ,Disease ,HM ,0302 clinical medicine ,Anàlisi de variància ,130 000 Cognitive Neurology & Memory ,diagnostic imaging [Cerebral Cortex] ,sexual characteristics ,Analysis of variance ,nuclear magnetic resonance imaging ,Cervell ,Research Articles ,Cerebral Cortex ,Sex Characteristics ,Radiological and Ultrasound Technology ,05 social sciences ,Brain ,clinical trial ,Brain Structure ,Magnetic Resonance Imaging ,Early life ,Adolescence ,medicine.anatomical_structure ,Neurology ,Cerebral cortex ,Healthy individuals ,X-CHROMOSOME ,anatomy & histology [Cerebral Cortex] ,Evolution of the brain ,Female ,Anatomy ,Neurovetenskaper ,Research Article ,Radiology, Nuclear Medicine and Medical Imaging ,Neuroinformatics ,SEX-DIFFERENCES ,diagnostic imaging ,brain ,Human Development ,BF ,Neuroimaging ,SURFACE-AREA ,Evolució del cervell ,Regional area ,Biology ,MULTISAMPLE ,050105 experimental psychology ,brain cortex ,03 medical and health sciences ,CEREBRAL-CORTEX ,Sex differences ,medicine ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,human ,ddc:610 ,Cortical surface ,GENERAL INTELLIGENCE ,diagnostic imaging [Brain] ,METAANALYSIS ,biological variation ,HUMAN HIPPOCAMPUS ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,physiology [Biological Variation, Population] ,Neurosciences ,Gender ,Brain Cortical Thickness ,multicenter study ,Biological Variation, Population ,Diferències entre sexes ,physiology ,RC0321 ,Radiologi och bildbehandling ,Neurology (clinical) ,anatomy & histology [Brain] ,170 000 Motivational & Cognitive Control ,030217 neurology & neurosurgery ,anatomy and histology ,meta analysis ,physiology [Human Development] ,Demography - Abstract
Contains fulltext : 248376.pdf (Publisher’s version ) (Open Access) For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
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- 2022
34. Tracking temporal response dynamics in the ventral striatum during social feedback in anorexia nervosa: A functional magnetic resonance imaging exploratory study
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Marina López-Solà, Ben J. Harrison, Sonia Membrives, José M. Menchón, Charlotte Keating, Carles Soriano-Mas, Ignacio Martínez-Zalacaín, Jesús Pujol, Esther Via, Christopher G. Davey, Susan L. Rossell, Fernando Fernández-Aranda, Narcís Cardoner, Diego Palao, Joan Carles Oliva, and Isabel Sánchez
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medicine.medical_specialty ,Anorexia Nervosa ,medicine.diagnostic_test ,business.industry ,Ventral striatum ,Exploratory research ,Hemodynamics ,Audiology ,Magnetic Resonance Imaging ,Feedback ,Psychiatry and Mental health ,Social feedback ,Reward system ,medicine.anatomical_structure ,Reward ,Anorexia nervosa (differential diagnoses) ,Ventral Striatum ,Humans ,Medicine ,Female ,business ,Functional magnetic resonance imaging ,Social rejection - Abstract
Objective Research suggests abnormalities in reward-based processes in anorexia nervosa (AN). However, few studies have explored if such alterations might be associated with different temporal activation patterns. This study aims to characterize alterations in time-dependent processes in the ventral striatum (VS) during social feedback in AN using functional magnetic resonance imaging (fMRI). Method Twenty women with restrictive-subtype AN and 20 age-matched healthy controls (HC) underwent a social judgment experimental fMRI task. Temporal VS hemodynamic responses were extracted in SPM for each participant and each social condition (acceptance/rejection). Results Compared with age-matched HC, patients with AN showed a significant time by group interaction of peak VS response throughout the task, with a progressive blunting of peak activation responses, accompanied by a progressive increase in baseline activity levels over time. Discussion The results suggest an attenuated response pattern to repetitive social rejection in the VS in patients with AN, together with a difficulty in returning to baseline. The information obtained from this study will guide future, design-specific studies to further explore alterations temporal dynamics.
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- 2021
35. Prevalence and correlates of current suicide risk in an international sample of OCD adults: A report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network and Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology
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Christine Lochner, Luchezar Hranov, M. Figee, Maria Filippou-Frye, Dan J. Stein, José M. Menchón, Leonardo F. Fontenelle, Carolyn I. Rodriguez, Eric Hollander, Stefano Pallanti, Andrea Varias, Michael Van Ameringen, Naomi A. Fineberg, Damiaan Denys, Bernardo Dell'Osso, Beatrice Benatti, Humberto Nicolini, Nuria Lanzagorta, Jon E. Grant, Donatella Marazziti, Booil Jo, Oğuz Karamustafalıoğlu, Lynne M. Drummond, Hanyang Shen, Luca Pellegrini, Joseph Zohar, Catherine Sanchez, Adult Psychiatry, and ANS - Compulsivity, Impulsivity & Attention
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Adult ,Obsessive-Compulsive Disorder ,Generalized anxiety disorder ,Compulsive Personality Disorder ,Population ,Suicide, Attempted ,Suicide risk ,Comorbidity ,Article ,Severity of illness ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Prevalence ,Humans ,education ,Biological Psychiatry ,Depression (differential diagnoses) ,education.field_of_study ,Disability ,Obsessive–compulsive spectrum ,business.industry ,medicine.disease ,030227 psychiatry ,Neuropsychopharmacology ,Psychiatry and Mental health ,Distress ,Cross-Sectional Studies ,Obsessive compulsive disorder ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Introduction: Obsessive-compulsive disorder (OCD), characterized by repetitive anxiety-inducing intrusive thoughts and compulsive behaviors, is associated with higher suicide ideation and suicide attempts than the general population. This study investigates the prevalence and the correlates of current suicide risk in adult outpatients in an international multisite cross-sectional sample of OCD outpatients. Methods: Data were derived from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network's cross-sectional data set (N = 409). Current suicide risk (assessed by Item C of the MINI) and diagnoses of psychiatric disorders were based on DSM-IV. Chi-squared test for categorical variables and t-test for continuous variables were used to make statistical inferences about main features associated with current suicide risk. P < .05 was considered as statistically significant. Results: The prevalence of current suicidal risk was 15.9%, with equal likelihood in sociodemographic variables, including age and gender. Increased rates of major depression and generalized anxiety disorder were associated to higher current suicide risk. Current suicide risk was also associated with higher severity of OCD, depressive comorbidity, and higher levels of disability. There were no significant differences in treatment correlates—including type of treatment and psychiatric hospitalizations—between the groups of individuals with and without current suicide risk. Conclusion: Our findings suggest that current suicide risk is common in patients with OCD and associated with various forms of pathology. Our work also provides further empirical data to support what is already known clinically: a worse clinical picture characterized by a high severity of OCD, high distress related to obsessions and compulsions, and the presence of comorbidities such as major depression and generalized anxiety disorder should be considered as relevant risk factors for suicide risk.
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- 2021
36. Executive functions in binge spectrum eating disorders with comorbid compulsive buying
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María Lozano-Madrid, Susana Jiménez-Murcia, Fernando Fernández-Aranda, Lucero Munguía, Isabel Sánchez, Roser Granero, Giulia Testa, José M. Menchón, Romina Miranda-Olivos, Ignacio Lucas, Bernat Mora-Maltas, and Robert Turton
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Comorbidity ,Feeding and Eating Disorders ,Executive Function ,Compra compulsiva ,medicine ,Humans ,Bulimia ,Big Five personality traits ,Trastorns de la conducta alimentària ,business.industry ,Neuropsychology ,Novelty seeking ,Cognitive flexibility ,Compulsive shopping ,medicine.disease ,Executive functions ,Psychiatry and Mental health ,Clinical Psychology ,Eating disorders ,Compulsive Behavior ,Female ,business ,Binge-Eating Disorder ,Clinical psychology ,Psychopathology - Abstract
Objective: The aims were to explore if bulimic spectrum disorders (BSD) patients, who also present comorbid compulsive buying (CB), could represent a specific subtype considering its neuropsychological performance; to present a descriptive analysis of different clinical features; and to explore how these variables could influence treatment outcome. It was hypothesised that the comorbid group will present worse neuropsychological performance that will lead to a worse treatment outcome. Method: The study has a longitudinal design. Women (N = 75) diagnosed with BSD, BSD + CB and Healthy Controls (HC); completed an evaluation of: cognitive flexibility, decision making, eating disorder (ED) symptomatology, psychopathological state and personality traits. Results: BSD + CB was the group with the most severe clinical profile, worst treatment outcome and higher neuropsychological impairment, than other groups. Path-analysis evidenced that deficits in decision making were associated with bad treatment outcome, while deficits in flexibility with the presence of the comorbidity. Self-directedness and novelty seeking were associated with the neuropsychological performance and the comorbidity. Conclusion: BSD + CB exhibit a worse clinical and neuropsychological profile that seems to be related with the treatment outcome, which should be taken into account for the establishment of specific treatment approaches.
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- 2021
37. Cognitive Behavioral Therapy Plus a Serious Game as a Complementary Tool for a Patient With Parkinson Disease and Impulse Control Disorder: Case Report
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Teresa Mena-Moreno, Lucero Munguía, Rosario Granero, Ignacio Lucas, Almudena Sánchez-Gómez, Ana Cámara, Yaroslau Compta, Francesc Valldeoriola, Fernando Fernandez-Aranda, Anne Sauvaget, José M Menchón, and Susana Jiménez-Murcia
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Parkinson disease ,Serious game ,Psychiatry and Mental health ,Jocs seriosos ,Serious games ,Multidisciplinary approach ,Malaltia de Parkinson ,Parkinson's disease ,Rehabilitation ,Impulse control disorder ,Biomedical Engineering ,Hypersexuality ,Physical Therapy, Sports Therapy and Rehabilitation - Abstract
Background Impulse control disorders (ICDs) are commonly developed among patients who take dopamine agonist drugs as a treatment for Parkinson disease (PD). Gambling disorder and hypersexuality are more frequent in male patients with PD, with a prevalence over 4% in dopamine agonists users. Although impulsive-compulsive behaviors are related to antiparkinsonian medication, and even though ICD symptomatology, such as hypersexuality, often subsides when the dopaminergic dose is reduced, sometimes ICD persists in spite of drug adjustment. Consequently, a multidisciplinary approach should be considered to address these comorbidities and to explore new forms of complementary interventions, such as serious games or therapies adapted to PD. Objective The aim of this study is to present the case of a patient with ICD (ie, hypersexuality) triggered by dopaminergic medication for PD. A combined intervention was carried out using cognitive behavioral therapy (CBT) for ICD adapted to PD, plus an intervention using a serious game—e-Estesia—whose objective is to improve emotion regulation and impulsivity. The aim of the combination of these interventions was to reduce the harm of the disease. Methods After 20 CBT sessions, the patient received the e-Estesia intervention over 15 sessions. Repeated measures, before and after the combined intervention, were administered to assess emotion regulation, general psychopathology, and emotional distress and impulsivity. Results After the intervention with CBT techniques and e-Estesia, the patient presented fewer difficulties to regulate emotion, less emotional distress, and lower levels of impulsivity in comparison to before the treatment. Moreover, the frequency and severity of the relapses also decreased. Conclusions The combined intervention—CBT and a serious game—showed positive results in terms of treatment outcomes.
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- 2022
38. Brain Functional Connectivity Correlates of Subclinical Obsessive-Compulsive Symptoms in Healthy Children
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Maria Suñol, Jordi Sunyer, Jesús Pujol, Gerard Martínez-Vilavella, Ignacio Martínez-Zalacaín, O. Contreras-Rodríguez, José M. Menchón, Carles Soriano-Mas, Dídac Macià, and Cristina Saiz-Masvidal
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Male ,Obsessive-Compulsive Disorder ,medicine.medical_specialty ,Audiology ,Age and sex ,Article ,Neural Pathways ,Developmental and Educational Psychology ,medicine ,Humans ,0501 psychology and cognitive sciences ,Child ,Subclinical infection ,Brain Mapping ,medicine.diagnostic_test ,business.industry ,Functional connectivity ,Putamen ,05 social sciences ,Confounding ,Brain ,Magnetic Resonance Imaging ,Obsessive compulsive symptoms ,Psychiatry and Mental health ,nervous system ,Female ,Functional magnetic resonance imaging ,Large group ,business ,050104 developmental & child psychology - Abstract
Objective Commonly observed subclinical obsessive-compulsive symptoms in healthy children may predispose to obsessive-compulsive disorder (OCD). Therefore, investigating the underlying neurobiology may be relevant to identify alterations in specific brain circuits potentially accounting for clinical heterogeneity in OCD without the confounding effects of clinical samples. We analyzed the brain correlates of different obsessive-compulsive symptoms in a large group of healthy children using functional connectivity measures. Method We evaluated 227 healthy children (52% girls; mean [SD] age 9.71 [0.86] years; range, 8–12.1 years). Participants underwent clinical assessment with the Obsessive-Compulsive Inventory–Child Version and a resting-state functional magnetic resonance imaging examination. Total and symptom-specific severity were correlated with voxelwise global functional connectivity degree values. Significant clusters were then used as seeds of interest in seed-to-voxel analyses. Modulating effects of age and sex were also assessed. Results Global functional connectivity of the left ventral putamen and medial dorsal thalamus correlated negatively with total obsessive-compulsive symptom severity. Seed-to-voxel analyses revealed specific negative correlations from these clusters with limbic, sensorimotor, and insular regions in association with obsessing, ordering, and doubt-checking symptoms, respectively. Hoarding symptoms were associated with negative correlations between the left medial dorsal thalamus and a widespread pattern of regions, with such associations modulated by sex and age. Conclusion Our findings concur with prevailing neurobiological models of OCD on the importance of cortico-striato-thalamo-cortical dysfunction to account for symptom severity. Notably, we showed that changes in cortico-striato-thalamo-cortical connectivity are present at subclinical stages, which may result in an increased vulnerability for OCD. Moreover, we mapped different symptom dimensions onto specific cortico-striato-thalamo-cortical circuit attributes.
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- 2021
39. Ventilation Adjustment in ECT During COVID-19: Voluntary Hyperventilation is an Effective Strategy
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Mikel Urretavizcaya, Virginia Soria, Aida de Arriba-Arnau, Javier Labad, Antònia Dalmau Llitjos, and José M. Menchón
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Neuropsychiatric Disease and Treatment ,medicine.medical_treatment ,medicine.disease_cause ,electroconvulsive therapy anesthesia ,03 medical and health sciences ,0302 clinical medicine ,self-hyperventilation ,Hypocapnia ,Oxygen therapy ,Hyperventilation ,medicine ,Original Research ,business.industry ,Apnea ,ECT ,medicine.disease ,030227 psychiatry ,hypocapnia ,airway ,Anesthesia ,bag-mask ventilation ,Breathing ,Airway management ,oxygenation ,medicine.symptom ,business ,Nasal cannula ,Hypercapnia ,030217 neurology & neurosurgery - Abstract
Aida de Arriba-Arnau,1,2 Antònia Dalmau Llitjos,3 Virginia Soria,1,2,4 Javier Labad,2,5,6 José Manuel Menchón,1,2,4 Mikel Urretavizcaya1,2,4 1Department of Psychiatry, Bellvitge University Hospital-ICS, Bellvitge Biomedical Research Institute (IDIBELL), Neurosciences Group - Psychiatry and Mental Health. L’Hospitalet de Llobregat, Barcelona, Spain; 2Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Barcelona, Spain; 3Department of Anesthesiology, Reanimation and Pain Clinic, Bellvitge University Hospital-ICS, Universitat de Barcelona (UB), Barcelona, Spain; 4Department of Clinical Sciences, School of Medicine, Universitat de Barcelona (UB), Barcelona, Spain; 5Department of Mental Health, Consorci Sanitari del Maresme, Mataró, Spain; 6Parc Taulí, Institut d’Investigació i Innovació Parc Taulí (I3PT), Barcelona, SpainCorrespondence: Mikel UrretavizcayaSarachaga Department of Psychiatry. Bellvitge University Hospital – ICS, IDIBELL, CIBERSAM; UB Feixa Llarga s/n, 08907, L’Hospitalet de Llobregat, Barcelona, SpainTel +34 932607922Fax +34 932607658Email murretavizcaya@bellvitgehospital.catPurpose: Airway management is a key objective in adapted electroconvulsive therapy (ECT) protocols during the COVID-19 pandemic to prevent infection. The objective of this study was to describe the effectiveness of a modified ventilation procedure designed to reduce aerosol-generating bag-mask ventilation (BMV) and isolate possible droplets while maintaining adequate respiratory gas values in ECT sessions.Materials and Methods: This prospective study analyzed the results of the modified protocol applied over a month. Adaptations entailed preoxygenation and extension of the voluntary hyperventilation (VHV) time for two minutes before anesthesia induction, asking patients to hyperventilate with oxygen therapy via nasal cannula and while wearing a face mask. Thereafter, vigorous hyperventilation was avoided, and patients were only assisted with tightly sealed BMV until emergence from anesthesia, isolating the ventilation by using a single-use plastic device. Oxygen saturation (SpO2) and transcutaneous partial pressure of carbon dioxide (TcPCO2) were recorded throughout the session.Results: The study included 74 sessions of bilateral ECT with the modified ventilation protocol in 15 subjects. After VHV, the mean SpO2 increase was 2.12± 2.14%, and the mean TcPCO2 decrease was 4.05± 2.98 mmHg. TcPCO2 values at the moment of stimulus administration were 2.22± 3.07 mmHg below pre-ECT values. The mean EEG seizure was 38.70± 17.03 s, and postictal suppression was 68.31± 34.58% and 2.13± 0.75 on a 0– 3 scale. Brief desaturation (SpO2 < 90) of 4– 5 seconds duration was observed in 4 sessions.Conclusion: This modified ventilation protocol was effective during COVID-19, and it did not elicit significant side effects. In addition to avoiding vigorous BMV, it induced moderate hypocapnia, which has been tied to seizure optimization and less hypercapnia during the apnea period.Keywords: electroconvulsive therapy anesthesia, ECT, airway, bag-mask ventilation, oxygenation, self-hyperventilation, hypocapnia
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- 2021
40. Distinct Neural Processing of Acute Stress in Major Depression and Borderline Personality Disorder
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Ximena Goldberg, Carles Soriano-Mas, Martin P. Paulus, Rocío Alvarez Mercé, José M. Menchón, Salvador M. Guinjoan, Mariana N. Castro, Luis I. Brusco, Jerzy Bodurka, Mirta F. Villarreal, Soledad Ladrón de Guevara, and Agustina E. Wainsztein
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behavioral disciplines and activities ,03 medical and health sciences ,0302 clinical medicine ,Borderline Personality Disorder ,mental disorders ,medicine ,Humans ,Heart rate variability ,Generalizability theory ,Borderline personality disorder ,Depression (differential diagnoses) ,Depressive Disorder, Major ,Depression ,business.industry ,Brain ,medicine.disease ,Magnetic Resonance Imaging ,030227 psychiatry ,Peripheral ,Psychiatry and Mental health ,Clinical Psychology ,Cohort ,Biomarker (medicine) ,Major depressive disorder ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background Major depressive disorder (MDD) and borderline personality disorder (BPD) are highly prevalent and often comorbid psychiatric conditions, with abnormal processing of negative affect resulting from psychological stress. Characteristics of central processing of autonomic response to stress in each disorder are not clearly settled. Methods We obtained whole brain 3T fMRI with concurrent skin conductance, respiration rate, and heart rate variability measures in a cohort of MDD (N=19), BPD (N=19) patients, and healthy (N=20) individuals. Experiments were conducted in resting conditions, during a control mental arithmetic task, during highly stressful mental arithmetic, and in the period immediately following psychological stress. Results Widespread activation of central autonomic network (CAN) structures was observed during stress compared to a control task in the group of healthy participants, whereas CAN activation during stress was less intense in both BPD and MDD. Both patient groups displayed increased sympathetic and decreased parasympathetic activation compared to healthy subjects, as previously reported. The relationship between peripheral sympathetic or parasympathetic activity and simultaneous regional brain BOLD activity was similar in BPD patients and healthy subjects, and markedly different from that seen in MDD patients. Limitations The sample size, the fact it belonged to a single study site, and low grade affective symptomatology in both patient groups limit the generalizability of the present findings. Conclusions The diverging neurobiological signature in the homeostatic response to stress in MDD and BPD possibly represents a heuristically valuable candidate biomarker to help discern MDD and BPD patients.
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- 2021
41. Contribution of stressful life events to gambling activity in older age
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Susana Jiménez-Murcia, Neus Aymamí, Fernando Fernández-Aranda, Teresa Mena-Moreno, María Lozano-Madrid, Isabel Baenas, Roser Granero, Anne Sauvaget, Ester Codina, Hibai Lopez-Gonzalez, Jéssica Sánchez-González, Mónica Gómez-Peña, Cristina Vintró-Alcaraz, José M. Menchón, Laura Moragas, Amparo del Pino-Gutiérrez, Marco Camozzi, Isabel Sánchez, Gemma Mestre-Bach, Gemma Casalé-Salayet, Isabelle Giroux, Marie Grall-Bronnec, and Zaida Agüera
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Gerontology ,03 medical and health sciences ,0302 clinical medicine ,Health (social science) ,Arts and Humanities (miscellaneous) ,Social Psychology ,Public Health, Environmental and Occupational Health ,Life events ,030508 substance abuse ,Geriatrics and Gerontology ,0305 other medical science ,Psychology ,030227 psychiatry - Abstract
Older subjects are susceptible to develop gambling problems, and researchers have attempted to assess the mechanisms underlying the gambling profile in later life. The objective of this study was to identify the main stressful life events (SLE) across the lifespan which have discriminative capacity for detecting the presence of gambling disorder (GD) in older adults. Data from two independent samples of individuals aged 50+ were analysed: N = 47 patients seeking treatment at a Pathological Gambling Outpatient Unit and N = 361 participants recruited from the general population. Sexual problems (p < 0.001), exposure to domestic violent behaviour (p < 0.001), severe financial problems (p = 0.002), alcohol or drug-related problems (p = 0.004) and extramarital sex (p < 0.001) were related to a higher risk of GD, while getting married (p = 0.005), moving to a new home (p = 0.003) and moving to a new city (p = 0.006) decreased the likelihood of disordered gambling. The accumulated number of SLE was not a predictor of the presence of GD (p = 0.732), but patients who met clinical criteria for GD reported higher concurrence of SLE in time than control individuals (p < 0.001). Empirical research highlights the need to include older age groups in evidence-based policies for gambling prevention, because these individuals are at high risk of onset and/or progression of behavioural addiction-related problems such as GD. The results of this study may be useful for developing reliable screening/diagnostic tools and for planning effective early intervention programmes aimed to reduce the harm related to the onset and evolution of problem gambling in older adults.
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- 2020
42. Comorbid behavioral and substance-related addictions in young population with and without gambling disorder
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Zaida Agüera, Hibai Lopez-Gonzalez, Lucero Munguía, Teresa Mena-Moreno, Roser Granero, Ana Estévez, Laura Moragas, Bernat Mora-Maltas, María Lozano-Madrid, Paula Jauregui, Eduardo Valenciano-Mendoza, Mónica Gómez-Peña, Ester Codina, Amparo del Pino-Gutiérrez, Susana Jiménez-Murcia, Gemma Mestre-Bach, Giulia Testa, Cristina Vintró-Alcaraz, José M. Menchón, Laura Macia, Fernando Fernández-Aranda, and Isabel Baenas
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Coping (psychology) ,Food addiction ,Addiction ,media_common.quotation_subject ,030508 substance abuse ,medicine.disease ,Comorbidity ,Cognitive bias ,030227 psychiatry ,Substance abuse ,03 medical and health sciences ,0302 clinical medicine ,Young population ,medicine ,Gambling disorder ,0305 other medical science ,Psychology ,Applied Psychology ,Clinical psychology ,media_common - Abstract
People with gambling disorder (GD) often experience co-occurring addictive behaviors, especially at young ages. This paper aims at examining cognitive biases, emotion dysregulation, and coping stra...
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- 2020
43. Phenotype of Gambling Disorder Patients with Lotteries as a Preferred Form of Gambling
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Roser Granero, Fernando Fernández-Aranda, Teresa Mena-Moreno, Amparo del Pino-Gutierrez, Ester Codina, Mónica Gómez-Peña, Laura Moragas, Neus Aymamí, Gemma Mestre-Bach, Trevor Steward, Zaida Agüera, Anders Hakånsson, Cristina Vintró-Alcaraz, María Lozano-Madrid, Gemma Casalé-Salayet, Hibai López-González, Eduardo Valenciano-Mendoza, Bernat Mora-Maltas, Sandra Rivas-Pérez, José M. Menchón, and Susana Jiménez-Murcia
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Fenotip ,Psychiatry and Mental health ,Phenotype ,Loteries ,Joc compulsiu ,Compulsive gambling ,Lotteries - Abstract
Lottery gambling can become an addictive behavior which can significantly interfere with daily functioning. The objectives of this work were to estimate the prevalence of lottery gambling, to assess the profile related to this gambling type in a large clinical sample of patients who met criteria for gambling disorder (GD), and to compare this profile with the other two non-strategic forms of gambling (slot-machines and bingo). Sample included n = 3,531 patients consecutively attended for treatment-seeking due to gambling-related problems. All the participants met criteria for GD and were into the range of 18 to 85 years old. Sociodemographic variables, GD severity, psychopathological state, and personality traits were assessed. Statistical comparisons between the groups defined by the patients’ gambling preference (lotteries versus other gambling activities) were conducted, with chi-square test and analysis of variance. The prevalence of lotteries as the only gambling activity was 2.5%, 8.9% for lottery gambling as primary activity with other secondary gambling types, and 20.6% for lotteries as primary or secondary gambling activity. Lottery gambling and bingo gambling were more prevalent among women (bingo included the highest percentage of women). Compared to slot machine gambling, lotteries and bingo grouped older patients and those with later age of onset of the gambling-related problems. Bingo gambling showed the highest psychological distress and the most dysfunctional personality traits. This study shows the high frequency of lottery gambling among treatment-seeking for GD patients, and it provides empirical evidence about the profile associated with this gambling activity compared to other non-strategic gambling forms. The likelihood of lottery gambling is higher for women, patients married or living with a stable partner, and those within higher social position indexes.
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- 2022
44. Abnormalities in the default mode network in late-life depression: A study of resting-state fMRI
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Joan Guàrdia-Olmos, Carles Soriano-Mas, Lara Tormo-Rodríguez, Cristina Cañete-Massé, Inés del Cerro, Mikel Urretavizcaya, José M. Menchón, Virgina Soria, and Maribel Peró-Cebollero
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Clinical Psychology ,Mental depression ,Magnetic resonance imaging ,Imatges per ressonància magnètica ,Adults ,Depressió psíquica ,Older people ,Adulthood ,Persones grans - Abstract
Background/Objective: Neuroimaging studies have reported abnormalities in the examination of functional connectivity in late-life depression (LLD) in the default mode network (DMN). The present study aims to study resting-state functional connectivity within the DMN in people diagnosed with late-life major depressive disorder (MDD) compared to healthy controls (HCs). Moreover, we would like to differentiate these same connectivity patterns between participants with high vs. low anxiety levels. Method: The sample comprised 56 participants between the ages of 60 and 75; 27 of them were patients with a diagnosis of MDD. Patients were further divided into two samples according to anxiety level: the four people with the highest anxiety level and the five with the lowest anxiety level. Clinical aspects were measured using psychological questionnaires. Each participant underwent functional magnetic resonance imaging (fMRI) acquisition in different regions of interest (ROIs) of the DMN. Results: There was a greater correlation between pairs of ROIs in the control group than in patients with LLD, being this effect preferentially observed in patients with higher anxiety levels. Conclusions: There are differences in functional connectivity within the DMN depending on the level of psychopathology. This can be reflected in these correlations and in the number of clusters and how the brain lateralizes (clustering).
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- 2022
45. Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
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Cinto Segalàs, Raquel Rabionet, Marià Alemany, Pino Alonso, Sara Bertolín, Daniel Sanchez-Chinchilla, Jesse R. Willis, Marta Morell, Toni Gabaldón, Susanna Balcells, Geòrgia Escaramís, Xavier Estivill, Laura Domènech, Eva Real, and José M. Menchón
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Adult ,DNA, Bacterial ,Male ,Obsessive-Compulsive Disorder ,food.ingredient ,Rikenellaceae ,Firmicutes ,Science ,Oropharynx ,Biology ,Gut flora ,Prevotellaceae ,behavioral disciplines and activities ,Article ,Coprococcus ,Feces ,food ,Microbiologia oral ,RNA, Ribosomal, 16S ,Brain-Gut Axis ,mental disorders ,Obsessive-compulsive disorder ,Humans ,Microbiome ,Multidisciplinary ,Excrements ,Neurosi obsessiva ,Lachnospiraceae ,Fusobacteria ,Middle Aged ,biology.organism_classification ,Healthy Volunteers ,Gastrointestinal Microbiome ,Obsessive compulsive disorder ,Oral microbiology ,Case-Control Studies ,Immunology ,Metagenome ,Medicine ,Female ,Metagenomics ,Biomarkers - Abstract
Although the etiology of obsessive-compulsive disorder (OCD) is largely unknown, it is accepted that OCD is a complex disorder. There is a known bi-directional interaction between the gut microbiome and brain activity. Several authors have reported associations between changes in gut microbiota and neuropsychiatric disorders, including depression or autism. Furthermore, a pediatric-onset neuropsychiatric OCD-related syndrome occurs after streptococcal infection, which might indicate that exposure to certain microbes could be involved in OCD susceptibility. However, only one study has investigated the microbiome of OCD patients to date. We performed 16S ribosomal RNA gene-based metagenomic sequencing to analyze the stool and oropharyngeal microbiome composition of 32 OCD cases and 32 age and gender matched controls. We estimated different α- and β-diversity measures and performed LEfSe and Wilcoxon tests to assess differences in bacterial distribution. OCD stool samples showed a trend towards lower bacterial α-diversity, as well as an increase of the relative abundance of Rikenellaceae, particularly of the genus Alistipes, and lower relative abundance of Prevotellaceae, and two genera within the Lachnospiraceae: Agathobacer and Coprococcus. However, we did not observe a different Bacteroidetes to Firmicutes ratio between OCD cases and controls. Analysis of the oropharyngeal microbiome composition showed a lower Fusobacteria to Actinobacteria ratio in OCD cases. In conclusion, we observed an imbalance in the gut and oropharyngeal microbiomes of OCD cases, including, in stool, an increase of bacteria from the Rikenellaceae family, associated with gut inflammation, and a decrease of bacteria from the Coprococcus genus, associated with DOPAC synthesis. This project was supported by grants from the Spanish ministry of science and innovation (MICINN; SAF2013-49108-R); the Carlos III Health Institute (PI16/00950, PI18/00856, PI19/01184); FEDER funds (‘A way to build Europe’) and by the Agency of University and Research Funding Management of the Catalan Government (2014 SGR 1672 and 2017 SGR 738). We thank CERCA Programme / Generalitat de Catalunya for institutional support. LD was supported by a Severo Ochoa grant (SVP-2013-068066), MA was supported by the Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia Grant co-funded by the European Social Fund (ESF) “ESF, Investing in your future” (2017 FI_B 00327), DSC was supported by a grant from the MICINN (BES-2014-069814) and RR was supported by a fellowship from the Health Department of the Generalitat de Catalunya through the PERIS 2016-2020 program (SLT002/16/00310).
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- 2022
46. Cultural adaptation to Spanish of the#8220;Patient Satisfaction Survey#8221; to assess satisfaction with electroconvulsive therapy (ECT)
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Mikel, Urretavizcaya, Aída, De Arriba-Arnau, Montse, Caballero, Alexandra, Bagney, Miquel, Bernardo, José M, Menchón, and Roberto, Rodriguez-Jimenez
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Patient Satisfaction ,Surveys and Questionnaires ,Humans ,Personal Satisfaction ,Electroconvulsive Therapy - Abstract
The degree of satisfaction of patients and their relatives with electroconvulsive therapy (ECT) is considered an important treatment goal; however there is no scale in Spanish to quantify it. The aim of the study was to translate and adapt into Spanish the#8220;Patient Satisfaction Survey#8221; (PSS) for its use in patients and their relatives.
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- 2022
47. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part I: Anxiety disorders
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Borwin Bandelow, Christer Allgulander, David S. Baldwin, Daniel Lucas da Conceição Costa, Damiaan Denys, Nesrin Dilbaz, Katharina Domschke, Elias Eriksson, Naomi A. Fineberg, Josef Hättenschwiler, Eric Hollander, Hisanobu Kaiya, Tatiana Karavaeva, Siegfried Kasper, Martin Katzman, Yong-Ku Kim, Takeshi Inoue, Leslie Lim, Vasilios Masdrakis, José M. Menchón, Euripedes C. Miguel, Hans-Jürgen Möller, Antonio E. Nardi, Stefano Pallanti, Giampaolo Perna, Dan Rujescu, Vladan Starcevic, Dan J. Stein, Shih-Jen Tsai, Michael Van Ameringen, Anna Vasileva, Zhen Wang, Joseph Zohar, Adult Psychiatry, and ANS - Compulsivity, Impulsivity & Attention
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Psychiatry and Mental health ,children ,treatment ,adolescents ,guideline ,Biological Psychiatry ,Anxiety disorders - Abstract
Aim: This is the third version of the guideline of the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive–Compulsive and Posttraumatic Stress Disorders (published in 2002, revised in 2008). Method: A consensus panel of 33 international experts representing 22 countries developed recommendations based on efficacy and acceptability of available treatments. In total, 1007 RCTs for the treatment of these disorders in adults, adolescents, and children with medications, psychotherapy and other non-pharmacological interventions were evaluated, applying the same rigorous methods that are standard for the assessment of medications. Result: This paper, Part I, contains recommendations for the treatment of panic disorder/agoraphobia (PDA), generalised anxiety disorder (GAD), social anxiety disorder (SAD), specific phobias, mixed anxiety disorders in children and adolescents, separation anxiety and selective mutism. Selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are first-line medications. Cognitive behavioural therapy (CBT) is the first-line psychotherapy for anxiety disorders. The expert panel also made recommendations for patients not responding to standard treatments and recommendations against interventions with insufficient evidence. Conclusion: It is the goal of this initiative to provide treatment guidance for these disorders that has validity throughout the world.
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- 2022
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48. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders – Version 3. Part II: OCD and PTSD
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Borwin Bandelow, Christer Allgulander, David S. Baldwin, Daniel Lucas da Conceição Costa, Damiaan Denys, Nesrin Dilbaz, Katharina Domschke, Eric Hollander, Siegfried Kasper, Hans-Jürgen Möller, Elias Eriksson, Naomi A. Fineberg, Josef Hättenschwiler, Hisanobu Kaiya, Tatiana Karavaeva, Martin A. Katzman, Yong-Ku Kim, Takeshi Inoue, Leslie Lim, Vasilios Masdrakis, José M. Menchón, Euripedes C. Miguel, Antônio E. Nardi, Stefano Pallanti, Giampaolo Perna, Dan Rujescu, Vladan Starcevic, Dan J. Stein, Shih-Jen Tsai, Michael Van Ameringen, Anna Vasileva, Zhen Wang, Joseph Zohar, Adult Psychiatry, and ANS - Compulsivity, Impulsivity & Attention
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Psychiatry and Mental health ,children ,treatment ,posttraumatic stress disorder ,Obsessive-compulsive disorder ,guideline ,Biological Psychiatry - Abstract
Aim: This is the third version of the guideline of the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive–Compulsive and Posttraumatic Stress Disorders which was published in 2002 and revised in 2008. Method: A consensus panel of 34 international experts representing 22 countries developed recommendations based on efficacy and acceptability of the treatments. In this version, not only medications but also psychotherapies and other non-pharmacological interventions were evaluated, applying the same rigorous methods that are standard for the assessment of medication treatments. Result: The present paper (Part II) contains recommendations based on published randomised controlled trials (RCTs) for the treatment of OCD (n = 291) and PTSD (n = 234) in children, adolescents, and adults. The accompanying paper (Part I) contains the recommendations for the treatment of anxiety disorders. For OCD, first-line treatments are selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioural therapy (CBT). Internet-CBT was also superior to active controls. Several second-line medications are available, including clomipramine. For treatment-resistant cases, several options are available, including augmentation of SSRI treatment with antipsychotics and other drugs. Other non-pharmacological treatments, including repetitive transcranial magnetic stimulation (rTMS), deep brain stimulation (DBS) and others were also evaluated. For PTSD, SSRIs and the SNRI venlafaxine are first-line treatments. CBT is the psychotherapy modality with the best body of evidence. For treatment-unresponsive patients, augmentation of SSRI treatment with antipsychotics may be an option. Conclusion: OCD and PTSD can be effectively treated with CBT and medications.
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- 2022
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49. A Comparison of Gambling-Related Cognitions and Behaviors in Gamblers from the United States and Spain
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Trevor Steward, Iris M. Balodis, Fernando Fernández-Aranda, Roser Granero, Marc N. Potenza, Gemma Mestre-Bach, Cristina Vintró-Alcaraz, José M. Menchón, and Susana Jiménez-Murcia
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Sociology and Political Science ,Addiction ,media_common.quotation_subject ,Psychological intervention ,Cognition ,Impulsivity ,medicine.disease ,Substance abuse ,Scale (social sciences) ,Cultural diversity ,medicine ,Cross-cultural ,medicine.symptom ,Psychology ,General Psychology ,Clinical psychology ,media_common - Abstract
Few studies have compared the clinical characteristics of gambling disorder (GD) from a cross-cultural perspective. In the present study, we aimed to examine differences in gambling-related cognitions, gambling preferences, GD severity and other clinical and sociodemographic variables in individuals with GD in the United States and Spain. Two groups of participants with GD (from the United States of America (US; n = 109) and Spain (n = 243) were compared using the South Oaks gambling screen and the gambling-related cognitions scale. In Spain, the prevalence of participants who reported only non-strategic gambling preferences was higher, whereas in the US, participants tended to engage in a wider breadth of gambling activities. Moreover, Spanish participants reported higher GD severity, while participants in the US endorsed greater gambling-related cognitions. Our findings suggest that there may jurisdictional or cultural differences in terms of gambling-related cognitions, gambling preferences, and GD severity levels among individuals in the US versus Spain. These differences, which may reflect cultural regulatory or other factors, should be investigated further, and considered when developing and implementing interventions for GD.
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- 2020
50. The influence of chronological age on cognitive biases and impulsivity levels in male patients with gambling disorder
- Author
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S. Fabrizio Contaldo, Susana Valero-Solís, Susana Jiménez-Murcia, Fernando Fernández-Aranda, Laura Moragas, Mónica Gómez-Peña, Eduardo Valenciano-Mendoza, Roser Granero, Cristina Vintró, José M. Menchón, Isabel Baenas, Amparo del Pino-Gutiérrez, Teresa Mena-Moreno, Bernat Mora-Maltas, Neus Aymamí, and Gemma Mestre-Bach
- Subjects
Adult ,Male ,Aging ,Impulsivity ,Adolescent ,Older age ,030508 substance abuse ,Medicine (miscellaneous) ,Gambling disorder ,Severity of Illness Index ,Persones grans ,Structural equation modeling ,Thinking ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Sensation seeking ,Cognitive Dysfunction ,Path analysis ,Path analysis (statistics) ,Pathological ,Aged ,Age Factors ,Joc compulsiu ,Men ,General Medicine ,Middle Aged ,Moderation ,Cognitive bias ,030227 psychiatry ,Cognitive biases ,Younger age ,Psychiatry and Mental health ,Clinical Psychology ,Homes ,Gambling ,Impulsive Behavior ,Etiology ,Older people ,medicine.symptom ,Compulsive gambling ,0305 other medical science ,Psychology ,Clinical psychology - Abstract
Background and aimsDue to the contribution of age to the etiology of gambling disorder (GD), there is a need to assess the moderator effect of the aging process with other features that are highly related with the clinical profile. The objective of this study is to examine the role of the chronological age into the relationships between cognitive biases, impulsivity levels and gambling preference with the GD profile during adulthood.MethodsSample included n = 209 patients aged 18–77 years-old recruited from a Pathological Gambling Outpatients Unit. Orthogonal contrasts explored polynomial patterns in data, and path analysis implemented through structural equation modeling assessed the underlying mechanisms between the study variables.ResultsCompared to middle-age patients, younger and older age groups reported more impairing irrational beliefs (P = 0.005 for interpretative control and P = 0.043 for interpretative bias). A linear trend showed that as people get older sensation seeking (P = 0.006) and inability to stop gambling (P = 0.018) increase. Path analysis showed a direct effect between the cognitive bias and measures of gambling severity (standardized effects [SE] between 0.12 and 0.17) and a direct effect between impulsivity levels and cumulated debts due to gambling (SE = 0.22).ConclusionScreening tools and intervention plans should consider the aging process. Specific programs should be developed for younger and older age groups, since these are highly vulnerable to the consequences of gambling activities and impairment levels of impulsivity and cognitive biases.
- Published
- 2020
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