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Societal Impact Statement Alternative crops are a promising approach to address the global food shortage that is exacerbated by climate change and wealth disparities. Some of these alternative crops are traditional food plants that have been widely traded for centuries, whereas others have only recently become more popular. Chía is a traditional native “superfood” that is the fruit of three distinct mint species. Chía (Salvia hispanica) is commercially cultivated and shares nutritional properties with California thistle sage (Salvia carduacea) and desert chía (Salvia columbariae). These wild relatives of S. hispanica are adapted to arid conditions and have potentially valuable genetic variation for the development of chía agricultural varieties. The development of nutritious, drought‐tolerant crops such as chía will increase the resilience of people to the impact of climate upheaval. Summary In the Spanish language, the word chía refers to the nutlet fruits of several Salvia species native to Mesoamerica. The process of domestication of S. hispanica altered several traits, including the absence of shattering fruits, which makes harvest easier and mechanizable. S. hispanica is commercially cultivated in Mexico, South America, Australia, and less so in Europe and Africa. Other edible chía species are not commercially cultivated, including S. carduacea, and S. columbariae. These Californian chías are traditionally harvested by hand since the fruiting calices shatter and release the nutlets. Here we compare these three edible chía species, review their uses by native peoples, describe their morphology, summarize their natural distributions and cultivation, and provide an identification key. Native peoples in North America have traditionally used chías for food, medicine, and oil. S. hispanica naturally occurs throughout areas of Mexico that receive summer monsoonal rains. As such, it is a summer annual with an erect habit and cauline, simple leaves. In contrast, the Californian chía species are distributed through areas of the Mojave and Sonoran deserts that receive winter rains. They are winter annuals and their rosettes of lobed, pubescent leaves are typical adaptations to arid conditions. Nutlets in these chía species are similar when dry, but cultivated S. hispanica nutlets produce extensive mucilage when wetted, while the other chía produce mucilage to a lesser extent. As consumer interest grows in superfoods like chía, crop breeders may use wild chía to breed varieties appropriate for areas affected by drought or in desert agroecological systems.

IntroductionCardiovascular disease is the major cause of premature death in chronic kidney disease (CKD) and vascular damage is often detected belatedly, usually evaluated by expensive and invasive techniques. CKD involves specific risk factors that lead to vascular calcification and atherosclerosis, where inflammation plays a critical role. However, there are few inflammation-related markers to predict vascular damage in CKD. This study aimed to investigate immune populations in pre-dialysis patients to (i) identify subset alterations, (ii) assess longitudinal changes, and (iii) evaluate their applicability as biomarkers of subclinical vascular indices.Methods43 pre-dialysis CKD patients in stages CKD-2 to CKD-5 and 38 controls were recruited at baseline and after 18-month follow-up. Aortic stiffness was determined by carotid-femoral pulse wave velocity (PWV) and abdominal aortic calcification was quantified by the Kauppila index on X-rays. Carotid intima-media thickness, the number of carotid plaques and adventitial neovascularization were evaluated by Superb Microvascular Imaging. Peripheral blood mononuclear cells were isolated and immune cell populations were assessed by flow cytometry: senescent T cells (CD4+CD28null), Tang (CD3+CD31+CD184+) and derived subsets, and monocyte subsets (classical, intermediate and non-classical; and ACE expression).ResultsSenescent T cells were increased in CKD. Despite Tang levels were unchanged compared to controls, this subset exhibited enhanced immunosenescence traits (CD28null and inverted CD4+CD8+ ratio) in CKD. Furthermore, Tang were negatively correlated with CKD progression. Slight alterations within monocyte subsets were observed. These findings were validated at the 18-month follow-up. Tang were correlated with several subclinical indices, and further analyses revealed an independent effect on PWV and their potential value as biomarkers. Intermediate monocytes were positively correlated with PWV.ConclusionPre-dialysis CKD stages are hallmarked by alterations in immune cell populations related to vascular homeostasis, including early T-cell immunosenescence traits and a stage-dependent Tang depletion, which was independently related to vascular stiffness. All these features were replicated upon follow-up, thus providing validation toward our results. Our findings pave the ground for future studies addressing the functional contribution of these cellular mediators at the local level, assessing their potential predictive value in the long-term and implementing preventive strategies in the clinical setting.

Summary: Background: The clinical relevance of recurrent venous thromboembolism (VTE) after discontinuing anticoagulation in patients with COVID-19-associated VTE remains uncertain. We estimated the incidence rates and mortality of VTE recurrences developing after discontinuing anticoagulation in patients with COVID-19-associated VTE. Methods: A prospective, multicenter, non-interventional study was conducted between March 25, 2020, and July 26, 2023, including patients who had discontinued anticoagulation after at least 3 months of therapy. All patients from the registry were analyzed during the study period to verify inclusion criteria. Patients with superficial vein thrombosis, those who did not receive at least 3 months of anticoagulant therapy, and those who were followed for less than 15 days after discontinuing anticoagulation were excluded. Outcomes were: 1) Incidence rates of symptomatic VTE recurrences, and 2) fatal PE. The rate of VTE recurrences was defined as the number of patients with recurrent VTE divided by the patient-years at risk of recurrent VTE during the period when anticoagulation was discontinued. Findings: Among 1106 patients with COVID-19-associated VTE (age 62.3 ± 14.4 years; 62.9% male) followed-up for 12.5 months (p25-75, 6.3–20.1) after discontinuing anticoagulation, there were 38 VTE recurrences (3.5%, 95% confidence interval [CI]: 2.5–4.7%), with a rate of 3.1 per 100 patient-years (95% CI: 2.2–4.2). No patient died of recurrent PE (0%, 95% CI: 0–7.6%). Subgroup analyses showed that patients with diagnosis in 2021–2022 (vs. 2020) (Hazard ratio [HR] 2.86; 95% CI 1.45–5.68) or those with isolated deep vein thrombosis (vs. pulmonary embolism) (HR 2.31; 95% CI 1.19–4.49) had significantly higher rates of VTE recurrences. Interpretation: In patients with COVID-19-associated VTE who discontinued anticoagulation after at least 3 months of treatment, the incidence rate of recurrent VTE and the case-fatality rate was low. Therefore, it conceivable that long-term anticoagulation may not be required for many patients with COVID-19-associated VTE, although further research is needed to confirm these findings. Funding: Sanofi and Rovi, Sanofi Spain.

La economía puede incrementar el bienestar social haciendo progresar el capital físico, el capital humano y la tecnología. Es sobre este último factor, clave en relación con los otros dos, sobre el que versa este estudio. En los centros de investigación españoles, particularmente los universitarios, se produce un alto número de resultados de notable calidad, lo que no se traslada, en proporción semejante, al campo de las innovaciones y de la aplicabilidad industrial. Desde un análisis de los datos, intentamos ilustrar esa brecha que existe entre investigación e innovación comercializable en el país que ocupa el cuarto puesto en la UE, tanto por el volumen de su PIB como por el número de sus ciudadanos. The economy can increase social welfare by advancing physical capital, human capital and technology. It is on this last factor, which is key in relation to the other two, that this study focuses. Spanish research centres, particularly universities, produce a high number of results of notable quality, but this does not translate, in similar proportion, to the field of innovation and industrial applicability. From an analysis of the data, we attempt to illustrate the gap that exists between research and marketable innovation in the country that ranks fourth in the EU, both in terms of the volume of its GDP and the number of its citizens.

Matisia Bonpl. is a genus of Malvaceae (Matisieae) that is distributed from Nicaragua to Brazil. Twelve species of Matisia have been recorded in Panama. In this article, we add two species to the Panamanian flora, Matisia gentryi Fern.Alonso and M. tinamastiana A.Estrada & Cascante, and provide for both species full descriptions, images, a distribution map, taxonomic notes, and conservation status. Additionally, we provide an identification key for Matisia in Panama and propose the synonymization of Matisia sect. Tuberculatae Fern.Alonso under Matisia sect. Matisia.

Research on medicinal plants is essential for their conservation, propagation, resistance to environmental stress, and domestication. The use of organic nutrition has been demonstrated to improve soil fertility and plant quality. It is also important to study the effects of the Basic Cation Saturation Ratio (BCSR) approach, which is a topic where there is currently controversy and limited scientific information. Evaluating the growth and yields of Agastache mexicana subsp. mexicana (Amm) in different environments is crucial for developing effective propagation and domestication strategies. This includes examining warm and subhumid environments with rain in summer in comparison to mild environments with summer rain. Significant differences were observed in the effects of cold, waterlogging, and heat stresses on the plant’s biomass yield and the morphometric-quantitative modeling by means of isolines. The biomass yield was 56% higher in environment one compared to environment two, 19% higher in environment one with organic nutrition, and 48% higher in environment two with organic nutrition compared to using only BCSR nutrition. In the second harvesting cycle, the plants in environment one did not survive, while the plants in environment two managed to survive without needing additional nutrition. Statistical and mathematical analyses provided information about the population or sample. Additionally, further analysis using isolines as a new approach revealed new insights into understanding phenology and growth issues.

Current antibiograms cannot discern the particular effect of a specific antibiotic when the bacteria are incubated with a mixture of antibiotics. To prove that this task is achievable, Escherichia coli strains were treated with ciprofloxacin for 45 min, immobilized on a slide and stained with SYBR Gold. In susceptible strains, the nucleoid relative surface started to decrease near the MIC, being progressively condensed as the dose increased. The shrinkage level correlated with the DNA fragmentation degree. Ciprofloxacin-resistant bacilli showed no change. Additionally, E. coli strains were incubated with ampicillin for 45 min and processed similarly. The ampicillin-susceptible strain revealed intercellular DNA fragments that increased with dose, unlike the resistant strain. Co-incubation with both antibiotics revealed that ampicillin did not modify the nucleoid condensation effect of ciprofloxacin, whereas the quinolone partially decreased the background of DNA fragments induced by ampicillin. Sixty clinical isolates, with different combinations of susceptibility-resistance to each antibiotic, were co-incubated with the EUCAST breakpoints of susceptibility of ciprofloxacin and ampicillin. The morphological assay correctly categorized all the strains for each antibiotic in 60 min, demonstrating the feasible independent evaluation of a mixture of quinolone and beta-lactam. The rapid phenotypic assay may shorten the incubation times and necessary microbial mass currently required for evaluation.

Se describe e ilustra una especie nueva de Salvia de la Cordillera Oriental de Colombia que tiene flores resupinadas, un raro atributo en este género. Se discute la circunscripción y composición de Salvia sección Tubiflorae a la cual se adscribe la nueva especie. Se propone la inclusión de la pequeña sección Killipiana (con dos especies de Colombia) dentro de la sección Tubiflorae. Se presenta una breve sinopsis de la sección Tubiflorae ampliada, que agrupa a 18 taxones (15 especies y tres subespecies) distribuidos desde México hasta Brasil (incluídas Las Antillas).

BackgroundMultidrug-resistant Acinetobacter baumannii is a common hospital-acquired pathogen. The increase in antibiotic resistance is commonly due to the acquisition of mobile genetic elements carrying antibiotic resistance genes. To comprehend this, we analyzed the resistome and virulome of Mexican A. baumannii multidrug-resistant isolates.MethodsSix clinical strains of A. baumannii from three Mexican hospitals were sequenced using the Illumina platform, the genomes were assembled with SPAdes and annotated with Prokka. Plasmid SPAdes and MobRecon were used to identify the potential plasmid sequences. Sequence Type (ST) assignation under the MLST Oxford scheme was performed using the PubMLST database. Homologous gene search for known virulent factors was performed using the virulence factor database VFDB and an in silico prediction of the resistome was conducted via the ResFinder databases.ResultsThe six strains studied belong to different STs and clonal complexes (CC): two strains were ST208 and one was ST369; these two STs belong to the same lineage CC92, which is part of the international clone (IC) 2. Another two strains were ST758 and one was ST1054, both STs belonging to the same lineage CC636, which is within IC5. The resistome analysis of the six strains identified between 7 to 14 antibiotic resistance genes to different families of drugs, including beta-lactams, aminoglycosides, fluoroquinolones and carbapenems. We detected between 1 to 4 plasmids per strain with sizes from 1,800 bp to 111,044 bp. Two strains from hospitals in Mexico City and Guadalajara had a plasmid each of 10,012 bp pAba78r and pAba79f, respectively, which contained the blaOXA-72 gene. The structure of this plasmid showed the same 13 genes in both strains, but 4 of them were inverted in one of the strains. Finally, the six strains contain 49 identical virulence genes related to immune response evasion, quorum-sensing, and secretion systems, among others.ConclusionResistance to carbapenems due to pAba78r and pAba79f plasmids in Aba pandrug-resistant strains from different geographic areas of Mexico and different clones was detected. Our results provide further evidence that plasmids are highly relevant for the horizontal transfer of antibiotic resistance genes between different clones of A. baumannii.

En base a la investigación Biodiversidad, economía y empleo en España. Análisis y perspectivas de futuro (Oteros et al, 2022), nos centramos en las dimensiones de cambio de modelo productivo y, especialmente, en las ocupaciones y en el empleo, respetuosas con la biodiversidad. El objetivo consiste en: a) Examinar la inversión, gasto y tipo de actuación de la economía española en relación con el empleo y la biodiversidad entre 2011 y 2019;b) proyectar el empleo, bajo hipótesis de cambio hacia un modelo productivo basado en un metabolismo sociedad-naturaleza compatible respetuoso con la biodiversidad, proyectando para el periodo 2019-2028, según diferentes escenarios, de transición suave o intensa, en la estructura de ocupaciones; c) sugerir potenciales líneas de transformación necesarias -reconversiones de actividades y cambios en el tiempo de trabajo- para posibilitar una transición ecológica socialmente justa cuyas condiciones puedan prevenir los peligros que acechan a la biodiversidad en España.

En este avance de la revisión taxonómica del género Quararibea (Malvaceae), se describe una especie nueva, conocida solo de los bosques de niebla de la Comarca de Ngabe-Buglé, en la Cordillera Central de Panamá. Se compara y comenta su morfología y distribución con las de Quararibea santaritensis, Q. yunckeriQ. cryptantha, Q. nigrescens y otras especies de Centro y Sudamérica, aquí consideradas afines. Se incluye una clave para identificar las especies comentadas y una relación de las colecciones revisadas de estas especies.

Bloodstream infections due to bacteria are a highly consequential nosocomial occurrences and the organisms responsible for them are usually multidrug-resistant. The aims of this study were to describe the incidence of bacteremia caused by Gram-negative ESKAPE bacilli during the COVID-19 pandemic and characterize the clinical and microbiological findings including antimicrobial resistance. A total of 115 Gram-negative ESKAPE isolates were collected from patients with nosocomial bacteremia (18% of the total bacteremias) in a tertiary care center in Mexico City from February 2020 to January 2021. These isolates were more frequently derived from the Respiratory Diseases Ward (27), followed by the Neurosurgery (12), Intensive Care Unit (11), Internal Medicine (11), and Infectious Diseases Unit (7). The most frequently isolated bacteria were Acinetobacter baumannii (34%), followed by Klebsiella pneumoniae (28%), Pseudomonas aeruginosa (23%) and Enterobacter spp (16%). A. baumannii showed the highest levels of multidrug-resistance (100%), followed by K. pneumoniae (87%), Enterobacter spp (34%) and P. aeruginosa (20%). The blaCTX-M-15 and blaTEM-1 genes were identified in all beta-lactam-resistant K. pneumoniae (27), while blaTEM-1 was found in 84.6% (33/39) of A. baumannii isolates. The carbapenemase gene blaOXA-398 was predominant among carbapenem-resistant A. baumannii (74%, 29/39) and blaOXA-24was detected in four isolates. One P. aeruginosa isolate was blaVIM-2 gene carrier, while two K. pneumoniae and one Enterobacter spp were blaNDM gene carriers. Among colistin-resistant isolates mcr-1 gene was not detected. Clonal diversity was observed in K. pneumoniae, P. aeruginosa and Enterobacter spp. Two outbreaks caused by A. baumannii ST208 and ST369 were detected, both belonging to the clonal complex CC92 and IC2. A. baumannii was associated with a death rate of 72% (28/32), most of them (86%, 24/28) extensively drug-resistant or pandrug-resistant isolates, mainly in patients with COVID-19 (86%, 24/28) in the Respiratory Diseases Ward. A. baumannii isolates had a higher mortality rate (72%), which was higher in patients with COVID-19. There was no statistically significant association between the multidrug-resistant profile in Gram-negative ESKAPE bacilli and COVID-19 disease. The results point to the important role of multidrug-resistant Gram-negative ESKAPE bacteria causing bacteremia in nosocomial settings before and during the COVID-19 epidemic. Additionally, we were unable to identify a local impact of the COVID-19 pandemic on antimicrobial resistance rates, at least in the short term.

Partiendo de los edificios del Departamento de Ciencias de la Administración, UNS, como unidades de análisis, se reconoce que las condiciones mínimas de habitabilidad dependen de un significativo insumo de energía auxiliar; registrando importantes costos económicos y ambientales. Consecuentemente, basados en estudios previos y un Proyecto de Grupos de Investigación (PGI) UNS 2018-2020, se infiere que el mejoramiento de la calidad tecnológica en la envolvente de la edificación existente, asegura beneficios higro-térmicos y ambientales en forma inmediata y beneficios económicos en períodos mediatos. A tal fin, en el presente artículo se describe: el marco de actuación; los objetivos de la investigación; la metodología de trabajo; y el desarrollo de los principales análisis y resultados de la investigación. Como conclusión, se reconoce que la aplicación de las alternativas tecnológico-constructivo en la edilicia existente presenta beneficios para todos los actores involucrados: el Estado, los usuarios y la salud del edificio.

Las bajas calidades constructivas en la vivienda producen una demanda permanente de energía auxiliar para sostener niveles mínimos de habitabilidad, generando una elevada dependencia urbana del insumo energético, impactando significativamente sobre la matriz energética nacional. En consecuencia, se plantea a la eficiencia energética edilicia (EEE) como estrategia prioritaria de mitigación; generando beneficios para todos los actores intervinientes. Impulsados por tales inferencias, se ha trabajado en etapas concatenadas: una primera de investigación y desarrollo (a través de investigaciones en la FAU-UNLP y CONICET), una segunda etapa de difusión y capacitación (desde el CAPBA), y una propuesta de tercera etapa en formación académica (desde la UNS). A modo de conclusión se remarca que la aplicación de la EEE sobre el parque residencial requiere de la participación sinérgica del sector público y el privado, a partir de lo cual se obtienen beneficios para todos los actores intervinientes (organismos de gobierno, cuerpos colegiados, profesionales y usuarios).

Este artículo propone una revisión de mediatizaciones de sonido/audio consideradas como novedosas en el actual ecosistema mediático. Se trata de fenómenos propios del ecosistema de plataformas, pero también tienen incidencia en la vida cotidiana. Sería imposible realizar un recorrido exhaustivo desde propuestas para intersticios individuales o interindividuales hasta aquellas que procuran un alcance masivo. Entre las primeras se encuentran las aplicaciones para órdenes de voz o los mensajes de audio en las de plataformas de mensajes; entre las segundas, serán revisados el renacer del audiolibro y la explosión del podcasting. La metodología será la de la sociosemiótica de las mediatizaciones con un enfoque ecosistémico. El objetivo central es ofrecer un aporte más a las prácticas interdisciplinarias con las que se vienen investigando las mediatizaciones soportadas en redes sociales. Se tendrán en cuenta tres niveles: el de los dispositivos técnicos aplicados en la producción, distribución y recepción, el de los formatos discursivos que se proponen y sus relaciones con diferentes tipos de movilidad en la recepción. El momento actual será comparado con los momentos previos de las mediatizaciones de sonido/audio para establecer las permanencias y las continuidades.

Solar domestic water heaters (SWH) with thermosyphon circulation are the most common commercial applications of solar energy in Mexico. They are also becoming popular in the rest of the world, given their simplicity, good economic returns, and sustainability. Traditionally the solar collector, the piping, and the storage tank are built of copper and steel. However, water quality in many parts of the Mexican Northwest has high mineral contents and, when heated, results in early metal pitting corrosion of SWH parts. Short-lived water heaters are bad promoters of the technology. In this work, a SWH thermoplastic Chlorinated Polyvinyl Chloride (CPVC) is built and tested under real operating conditions in La Paz, BCS, Mexico. The optimal design is detected with the aid of a suitable numerical model. Results reveal that a full SWH-CPVC can be technically and economically convenient for the weather conditions of the Northwestern states of Mexico.

Vascular calcification (VC) is a common complication in patients with chronic kidney disease which increases their mortality. Although oxidative stress is involved in the onset and progression of this disorder, the specific role of some of the main redox regulators, such as catalase, the main scavenger of H2O2, remains unclear. In the present study, epigastric arteries of kidney transplant recipients, a rat model of VC, and an in vitro model of VC exhibiting catalase (Cts) overexpression were analysed. Pericalcified areas of human epigastric arteries had increased levels of catalase and cytoplasmic, rather than nuclear runt-related transcription factor 2 (RUNX2). In the rat model, advanced aortic VC concurred with lower levels of the H2O2-scavenger glutathione peroxidase 3 compared to controls. In an early model of calcification using vascular smooth muscle cells (VSMCs), Cts VSMCs showed the expected increase in total levels of RUNX2. However, Cts VMSCs also exhibited a lower percentage of the nucleus stained for RUNX2 in response to calcifying media. In this early model of VC, we did not observe a dysregulation of the mitochondrial redox state; instead, an increase in the general redox state was observed in the cytoplasm. These results highlight the complex role of antioxidant enzymes as catalase by regulation of RUNX2 subcellular location delaying the onset of VC.

Medicinal plants are crucial for developing new medicines; the Agastache mexicana subspecies mexicana (Amm) or “toronjil morado” is considered an at-risk plant because of its inability to grow outside of its natural habitat. This research aims to measure the response of Amm to achieve survival with low nutrient levels and water stress, supported by different dioxide silicon (SiO2) (0.0, 0.2, 0.4, and 0.8%) and artificial shading (AS) levels (38, 87, and 94%). Applying AS and SiO2 supported gradual tolerance to the effects of both waterlogging and drought stresses. The survival values were statistically significant in the interaction and simple analysis of SiO2 and AS, where p = 0.0001. The highest survival percentage (SP) value was SP = 91.3% for treatment number six (τ6), where AS = 94% and SiO2 = 0.2%. Additionally, the index of survival efficiency under water stress (SIef) was calculated, with the highest value being SIef = 0.062 for the hypothetical interaction of AS = 94% and SiO2 = 0.4. Research has shown that applying both SiO2 and a high level of AS can guarantee the survival of Amm under water stress.

Acinetobacter baumannii is an opportunistic pathogen responsible for healthcare-associated infections (HAIs) and outbreaks. Antimicrobial resistance mechanisms and virulence factors allow it to survive and spread in the hospital environment. However, the molecular mechanisms of these traits and their association with international clones are frequently unknown in low- and middle-income countries. Here, we analyze the phenotype and genotype of seventy-six HAIs and outbreak-causing A. baumannii isolates from a Mexican hospital over ten years, with special attention to the carbapenem resistome and biofilm formation. The isolates belonged to the global international clone (IC) 2 and the Latin America endemic IC5 and were predominantly extensively drug-resistant (XDR). Oxacillinases were identified as a common source of carbapenem resistance. We noted the presence of the blaOXA-143-like family (not previously described in Mexico), the blaOXA-72 and the blaOXA-398 found in both ICs. A low prevalence of efflux pump overexpression activity associated with carbapenem resistance was observed. Finally, strong biofilm formation was found, and significant biofilm-related genes were identified, including bfmRS, csuA/BABCDE, pgaABCD and ompA. This study provides a comprehensive profile of the carbapenem resistome of A. baumannii isolates belonging to the same pulse type, along with their significant biofilm formation capacity. Furthermore, it contributes to a better understanding of their role in the recurrence of infection and the endemicity of these isolates in a Mexican hospital.

Abstract Osteoarthritis (OA) is a chronic degenerative joint disease, being the main cause of laboral inability. Decreased telomere size in peripheral blood leukocytes (PBL) has been correlated with age-related pathologies, like knee OA. In a dynamic approach, telomere-qPCR was performed to evaluate the relative percentage of PBL telomere loss after a 6-year follow-up, in 281 subjects from the prospective osteoarthritis initiative (OAI) cohort. A radiological Kellgren-Lawrence (KL) grade ≥ 2 was indicative of knee OA. Individuals with knee OA at recruitment (n = 144) showed a higher PBL telomere loss after 6 years than those without knee OA at baseline (n = 137; p = 0.018). Moreover, individuals that developed knee OA during the follow-up (n = 39) exhibited a higher telomere loss compared to those that remained without OA (n = 98; p

Se presentan los resultados de diversos muestreos llevados a cabo sobre parcelas cultivadas de pistachero en diferentes localidades de Castilla – La Mancha, en las provincias de Ciudad Real, Cuenca y Toledo. Se han encontrado un total de 8 especies de Curculionidae, de 5 géneros (Brachyderes, Otiorhynchus, Polydrusus, Sitona y Lixus) correspondientes a 2 subfamilias: ENTIMINAE y LIXINAE. Brachyderes marginellus, B. pubescens, Polydrusus subglaber, Otiorhynchus cribricollis y Lixus acicularis se han observado alimentándose de hojas de P. vera y se citan por primera vez sobre esta planta huésped. Polydrusus subglaber y Otiorhynchus cribricollis devoran intensamente sus hojas, por lo que se propone seguir investigando estas dos especies como importantes defoliadores de pistacho en la región. Se aportan datos biológicos y corológicos para las especies encontradas.

Una amplia mayoría de ciudadanos de la UE muestra un gran desinterés por los asuntos que conciernen a esta. De hecho, instituciones como la CECA, la CEE, el EURATOM o tratados como el de Maastricht, Ámsterdam, Niza o Lisboa raramente son temas de conversación. Tan solo el proceso de salida del Reino Unido despierta cierta preocupación, ya que se percibe que alguna influencia tendrá sobre nuestras economías. Se habla de Brexit, de withdrawal agreement, de backstop, etc., aunque sin llegar al fondo de estos conceptos. Desde su creación, la UE no ha parado de avanzar en la construcción de su proyecto de integración. Los gobiernos británicos no parecen haberse identificado del todo con el objetivo último del proceso: la unión política. Así pues, partiendo de una breve historia de la Unión, nos adentraremos en el evento de la Brexit, analizando lo que han supuesto estos cuatro años, tanto para la UE como para el RU, hasta la llegada del “huracán Johnson”, con sus controvertidas y polémicas decisiones.

A causa de la guerra en Siria se han multiplicado las llamadas que, desde hace varios años, se levantan pidiendo la reforma del Consejo de Seguridad. Algunos países y algunos dirigentes han comenzado a mostrar un desacuerdo más nítido que hace unas décadas tomando decisiones o haciendo declaraciones que afectan a dimensiones esenciales del mismo. Temas como la representatividad equitativa, el aumento del número de sus miembros o la cuestión del veto son algunos de los que llevan tiempo debatiéndose en ámbitos como el Open Ended Working Group o las Intergovernmental Negotiations. En este artículo presentamos, en una primera parte, una descripción de las propuestas de reforma, intentadas desde hace 25 años hasta el momento, en su afán de mejorar algunos aspectos del Consejo de Seguridad y ofrecemos, en una segunda parte, unas consideraciones finales que se desprenden de lo expuesto.

Desde los albores de la existencia humana, el sufrimiento, como constante antropológica, se ha constituido en una de las preocupaciones fundamentales de los hombres. Se le ha prestado atención constante, pero ello no ha de ser óbice para que no sigamos haciéndolo. La Filosofía puede contribuir a aportar luz a este concepto en nuestros días, en tanto en cuanto el problema del sufrimiento, a pesar de haber recibido respuestas muy distintas en las distintas épocas del pensar humano, parece persistir. Con el presente artículo buscamos aproximarnos al concepto del sufrimiento desde la luz que aportan algunos de los paradigmas filosóficos relevantes, al objeto de identificar algunas aplicaciones prácticas que favorezcan una gestión de recursos humanos más adecuada, tanto desde un punto de vista ético, como desde el lado de la rentabilidad empresarial. Ofrecemos por tanto propuestas para una gestión de recursos humanos responsable, sostenible y eficiente, de la mano del pensamiento filosófico.

Las competencias sociales y emocionales son cruciales para el éxito académico y social. Aunque existan programas para su promoción en las escuelas, no todo el profesorado está preparado para desarrollarlos. Este proyecto se centró en promover competencias sociales y emocionales en futuros maestros. Un total de 322 participantes fueron asignados a un grupo control y de intervención. Los estudiantes del grupo experimental recibieron sesiones relacionadas con sus asignaturas centradas en la mejora de competencias con una metodología interactiva. Los resultados muestran que la intervención fue efectiva para el grupo de innovación quiénes mostraron mayores competencias sociales y emocionales.

Se localiza y se confirma la existencia del holotipo de Plagionotus andreui Fuente 1908, en la colección Fuente. Se realiza un resumen de la historia nomenclatural y taxonómica de la especie hasta el presente.

The Iberian desman (Galemys pyrenaicus) is a small semi-aquatic mammal that inhabits mountainous areas from the centre to the north of the Iberian Peninsula and the Pyrenees and is listed as endangered because it has suffered a serious decline. Since 1960, only three species of digeneans (Omphalometra flexuosa, Maritrema pyrenaica and Mathovius galemydis) and two nematodes (Aonchotheca galemydis and Paracuaria hispanica) have been reported from the desman, but no further information on health status and no data from Extremadura has been available. The aim of our study was to characterise the diversity and distribution of parasites and microbiomes of desmans in different areas of the Central System of Extremadura. Between 2019 and 2021 we collected 238 fecal samples and one tissue (intestine) sample that was obtained from a dead desman. DNA templates were processed by commercial or customised real-time PCR using TaqMan probes. Representative data were obtained for Cryptosporidium spp., Omphalometra spp., Eimeria spp., Salmonella spp., Staphylococcus spp. and Leptospira spp. Omphalometra spp. was studied using a newly developed PCR test. The screening of the dead desman allowed us to obtain, for the first time, a partial sequence of the 18SrDNA. This study is the most complete study of the desman, allowing us to identify parasites and the microbiome in populations of G. pyrenaicus using non-invasive sampling.

An experiment is described to evaluate natural ventilation in a ten-story office building in Mexico City. The airflow results from the flotation of the internal hot air when the outside environment is colder. The objective of this work is to establish basic design considerations for effective ventilation of similar buildings. The experience is based on temperature measurements. These were taken at different levels in the building during several years and appear to be mutually consistent. A simple lumped-parameter mathematical model, which simulates the variation of temperature over time, fits well with the observed data. Some selected samples illustrate specific characteristics of the ventilation phenomenon. Thus, natural ventilation in other buildings can be designed to promote ventilation and improve comfort if there are some temperature measurements available for the calibration of the proposed model. The study validates the use of natural ventilation to provide passive thermal comfort throughout the year in Mexico City, although on some days slightly uncomfortable temperatures occur.

In this advance of the taxonomic revision that is being carried out in the genus Quararibea (Malvaceae) for the north of South America, three new species are described in this contribution, which are compared morphologically with the species considered related in each case. A first, Q. cornejoi, known from the wet forests of western Ecuador that we associate with Q. grandifolia and Q. casasecae, taxa also distributed in the Pacific corridor of Ecuador and Colombia. A second species, Q. latilimbata, from the sub-Andean forests of the Central Cordillera of the Department of Antioquia, Colombia, related to the previous species and to the Amazonian species Q. duckei. All of them with an unusual trait in the genus, an androecium with the long staminal branches. Finally, Q.villanuevae, from the dry forests of the upper Magdalena Valley in the Department of Tolima, Colombia, associated with the Andean species Q. foenigraeca and Q. caldasiana. These last three species, which have androecium with smaller staminal branches, are assigned to a different morphological group. Illustrations and detailed photographs of the new species are included as well as keys to the identification of the treated species.

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90‐day and 1‐year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90‐day all‐cause (odds ratio [OR], 2.81; 95% CI, 2.33–3.38) and PE‐related mortality (OR, 2.38; 95% CI, 1.37–4.14) and increased 1‐year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10–9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all‐cause mortality (OR, 1.91; 95% CI, 1.57–2.32) but not PE‐related mortality (OR, 1.50; 95% CI, 0.85–2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90‐day all‐cause (OR, 2.28; 95% CI, 1.75–2.97) and PE‐related (OR, 3.64; 95% CI, 2.01–6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.

ABSTRACT Acinetobacter baumannii has become one of the most important multidrug-resistant nosocomial pathogens all over the world. Nonetheless, very little is known about the diversity of A. baumannii lineages coexisting in hospital settings. Here, using whole-genome sequencing, epidemiological data, and antimicrobial susceptibility tests, we uncover the transmission dynamics of extensive and multidrug-resistant A. baumannii in a tertiary hospital over a decade. Our core genome phylogeny of almost 300 genomes suggests that there were several introductions of lineages from international clone 2 into the hospital. The molecular dating analysis shows that these introductions happened in 2006, 2007, and 2013. Furthermore, using the accessory genome, we show that these lineages were extensively disseminated across many wards in the hospital. Our results demonstrate that accessory genome variation can be a very powerful tool for conducting genomic epidemiology. We anticipate future studies employing the accessory genome along with the core genome as a powerful phylogenomic strategy to track bacterial transmissions over very short microevolutionary scales. IMPORTANCE Whole-genome sequencing for epidemiological investigations (genomic epidemiology) has been of paramount importance to understand the transmission dynamics of many bacterial (and nonbacterial) pathogens. Commonly, variation in the core genome, single nucleotide polymorphisms (SNPs), is employed to carry out genomic epidemiology. However, at very short periods of time, the core genome might not have accumulated enough variation (sufficient SNPs) to tell apart isolates. In this scenario, gene content variation in the accessory genome can be an option to conduct genomic epidemiology. Here, we used the accessory genome, as well as the core genome, to uncover the transmission dynamics of extensive and multidrug-resistant A. baumannii in a tertiary hospital for a decade. Our study shows that accessory genome variation can be a very powerful tool for conducting genomic epidemiology.

Abstract Background Relying solely on altruistic appeals may fail to fulfil the increasing demand for blood supplies. Current research has largely been attempted to determine and understand motives that serve as blood donation drivers. The Trans-Theoretical Model of behaviour change (TTM) can be used to conceptualise the process of intentional blood donation behaviour. Methods A cross sectional survey of Spanish adults was conducted. The final sample consisted of 504 individuals who were administered a self-report questionnaire including the measures of demographic characteristics, Stages of Change, Processes of Change, Self-efficacy and Decisional Balance. Data were analysed by frequency analysis, MANOVA/ANOVA and correlation analysis. Results Findings indicated that most of the behavioural and cognitive processes of change, self-efficacy and physical cons differentiated participants across the stages of change of blood donation. In contrast, eligibility cons and pros were less influential in stage transitions. Furthermore, significant correlations were observed between TTM constructs except for the physical cons and the processes of change. Conclusions The present study extensively supports and replicates the applicability of the TTM to blood donation behaviour change and offers important implications for the development of effective stage-matched interventions to increase blood donation.

Background: Bloodstream infections (BSIs) are the most frequent nosocomial infections in neonatal intensive care units (NICUs), especially in very low birth weight (VLBW) infants (birth weight ≤ 1500 g). An epidemiologic surveillance system may contribute to the prevention of infection by continuous monitoring of its frequency and associated risk factors. The aim of this article was to describe the implementation of the NeoKissEs surveillance system for BSIs in VLBW newborns in a group of Spanish NICUs. Methods: We assessed the clinical cohort consisting of all VLBW newborns aged less than 28 days admitted to the participating units. In the pilot phase, 2 NICUs translated and adapted materials from the original German NEO-KISS system. During implementation, 210 health care professionals attended one of 8 educational workshops. A web-based system was created that allows entering data regarding patients and BSI episodes, data monitoring, benchmarking and providing feedback to the units. At each NICU, one neonatologist was responsible for the implementation of the system and reporting the difficulties perceived throughout the process. Results: Out of the 50 units that agreed to participate, 45 successfully started using the surveillance platform during the implementation phase, recording 1108 episodes of catheter-associated BSI (CABSI) in 3638 newborns, and finding an overall rate of CABSI of 18.4 (95% CI, 17.8-19.1) per 1000 catheter days. Conclusions: The NeoKissEs surveillance system constitutes a helpful source of information for the purpose of benchmarking the performance of neonatal units, assessing factors associated with BSI in VLBW infants and measuring the impact of future preventive interventions in NICUs. Resumen: Antecedentes: Las sepsis son las infecciones nosocomiales más frecuentes en las Unidades de Cuidados Intensivos Neonatales (UCIN), afectando especialmente a los recién nacidos de muy bajo peso al nacer (RNMBP, ≤ 1.500 g). Un sistema de vigilancia epidemiológica puede contribuir a su prevención mediante una evaluación continua de su frecuencia y factores de riesgo asociados. El objetivo de este artículo es describir la implementación del sistema de vigilancia de las sepsis nosocomiales en RNMBP (NeoKissEs) en un grupo de UCIN españolas. Métodos: Estudio de cohorte de RNMBP con < 28 días de edad ingresados en las UCIN participantes. Dos UCIN tradujeron y adaptaron materiales a partir del sistema original alemán NEO-KISS. Durante la implementación, se desarrollaron 8 talleres formativos, con participación de 210 profesionales. Se creó un sistema web para la introducción de datos de pacientes y episodios de sepsis, su monitorización, análisis comparativo y retroalimentación a las unidades. En cada UCIN, un neonatólogo fue responsable de la implementación, recogiendo información sobre las dificultades percibidas durante el proceso. Resultados: De 50 unidades que aceptaron participar, 45 utilizaron NeoKissEs durante la fase de implementación, registrando 1.108 episodios de sepsis asociados a catéter vascular en 3.638 neonatos, con una tasa de 18,4 episodios por 1.000 pacientes-día con catéter (IC del 95%: 17,8-19,1). Conclusiones: El sistema de vigilancia epidemiológica NeoKissEs representa una fuente útil de información para la comparación estandarizada de la incidencia de sepsis de las UCIN, evaluar factores de riesgo y facilitar la evaluación del efecto de futuras intervenciones preventivas.

Se presenta un estudio taxonómico de las especies colombianas del género Pereskia (Pereskioideae, Cactaceae) basado en el análisis de atributos vegetativos y reproductivos de los ejemplares depositados, principalmente, en herbarios colombianos y algunos del exterior. En Colombia, el género Pereskia tiene tres especies: P. aculeata, P. bleo y P. guamacho. Se ofrece una clave dicotómica para el reconocimiento de las especies que se encuentran en el país, descripciones de éstas, iconografías, nombres comunes, distribución geográfica y comentarios sobre sus caracteres diagnósticos.

Cada vez más gobiernos han sustentado el desarrollo de su conocimiento a través de estrategias y políticas de mejora la educación superior, innovación e investigación. En Latinoamérica es incipiente la incorporación de sistemas tecnológicos para la construcción de ambientes de aprendizaje innovadores. La investigación tiene por objetivo caracterizar el alcance de la metodología de Aprendizaje Basado en Proyectos en la formación profesional de docentes en un ambiente e-learning de aprendizaje. Se diseñó un ambiente de aprendizaje en plataforma virtual Blackboard, con base en la sistematización de cinco fases fundamentadas en la metodología PBL, se empleó el diseño metodológico estudio de caso instrumental con una muestra de 60 estudiantes de diferentes partes de América Latina (92 % México, 3% Colombia y 5% Ecuador), los instrumentos que se emplearon fueron cuestionarios ad hoc y rúbricas de evaluación digitales. El análisis cualitativo de contenido evidencia una alta frecuencia en las categorías temáticas: vinculación de conceptos teórico-metodológicos, competencias de colaboración y trabajo en equipo, recursos digitales, programas y plataformas on-line. Se concluye que el impacto del ABP en los cursos de Posgrado favorece la motivación de los docentes en innovar su práctica educativa, así como la generación de un alto compromiso en el trabajo colaborativo enfocado a la resolución de problemas en contextos sociales-educativos en estudiantes de un programa de Maestría en Educación de financiamiento privado, con énfasis en la formación de innovación educativa. /// More governments have supported the development of their knowledge through strategies and policies to improve higher education, innovation and research. In Latin America, the incorporation of technological systems for the construction of innovative learning environments is still incipient. The objective of the research is to characterize the scope of the Project-Based Learning (PBL) methodology in the professional training of teachers in an e-learning learning environment. A learning environment was designed in the virtual platform Blackboard, based on the systematization of five phases based on the PBL methodology, the methodological design of the instrumental case study was used with a sample of 60 students from different parts of Latin America (92% Mexico, 3% Colombia and 5% Ecuador), the data collection instruments that were used were ad hoc questionnaires and digital evaluation rubrics. The qualitative analysis of content shows a high frequency in the thematic categories of: linking of theoretical-methodological concepts, collaboration and teamwork skills, digital resources, programs and on-line platforms. It is concluded that impact of PBL methodology in Postgraduate courses favors the motivation of teachers in innovating their educational practice, as well as the generation of a high commitment in the collaborative work focused on the resolution of problems in social-educational contexts in students of a Master's program in Education with private funding, and emphasis on educational innovation training.

Los últimos resultados de las evaluaciones nacionales e internacionales demuestran que el aprendizaje de las matemáticas resulta complejo para los estudiantes mexicanos. Distintos planes y técnicas se han puesto en marcha para tratar de contrarrestar dicho problema, y el uso de las tecnologías es uno de ellos. Durante las últimas dos décadas, la industria de los videojuegos en México ha ganado gran terreno entre la población de niños y jóvenes, es por ello, que se debe de aprovechar las ventajas que este tipo de herramientas tecnológicas tiene. En este trabajo, se presenta un juego serio para mejorar la alfabetización cuantitativa en niños de tercer grado de primaria. Para su diseño se utilizó un modelo de desarrollo iterativo que contempla cuatro etapas: planificación, desarrollo, evaluación y mejora; haciendo énfasis en el diseño de la instrucción. A través de un cuasiexperimento por un periodo de dos meses, el juego fue probado en un grupo de 33 alumnos de tercer grado del turno matutino. Los resultados obtenidos demostraron de forma cuantitativa un incremento en las habilidades de los alumnos. Se demostró que de los tres subconstructos que forman la alfabetización cuantitativa, dos de estos (números naturales y operaciones matemáticas) presentaron una mejora significativa tras el tratamiento. El juego serio fue del agrado de los estudiantes, por lo que como plan futuro se espera utilizar esta herramienta en distintas poblaciones. /// The last results of national and international evaluations, show that learning math is complex for Mexican students. Different plans and techniques have been implemented to counter this problem, one of them is the use of different technology in the classroom. During the last two decades, the videogame industry in Mexico has gained great traction among children, teenagers and young people, which is why the advantages of these kind of technologic tools must be harnessed. In this paper, we present a serious game to improve quantitative literacy in children studying the third grade of primary school. To design it, an iterative design model that contemplates four stages was use: planification, development, evaluation and improvement; emphasizing the instruction design. Through a quasi-experiment during a two-month period, the game was tested in a class of 33 morning shift third-grade students. The results obtained demonstrated quantitatively an increase in the students’ skills. It was shown, that out of the three subconstructs that constitute quantitative literacy, two of those (natural numbers and mathematical operations) showed significant improvement after treatment. The students enjoyed and engaged with the serious game, which is why it is expected to use this tool in the future in different Mexican communities.

The Catholic Church has developed fundamentally throughout the last decades, a significant contribution to the reflection on how to build political, economic and social relations based on the values of the Gospel, for the well-being of minkind. In 1967, Pope Paul VI published the encyclical letter Populorum Progressio in which he explained the conditions, from the perspective of the Church, so that a true development can take place, indicating that “in order for it to be authentic it must be integral, for the whole man and of all men ”(n. 14). Since the publication of this letter there have been significant changes in the business world, especially in relation to globalization and the advent of the so-called digital era. However, the deep keys of the proposal of Paul VI, of other texts of the Social Doctrine of the Church and of Christian anthropology, remain current. Christian social thought’s mission is to illuminate, as a prophecy, human action in this environment, which undergoes faster and faster transformations. This study aims to offer, from the Christian perspective, some keys that can serve as a guide for decision making, especially for the business environment, in times of changes and uncertainties of the so-called digital era. As a result, the article offers three proposals for the promotion of integral human development in the aforementioned context: unmasking ideologies, offering a clear model of a human being open to transcendence and fostering intergenerational cooperation.

Objectives: To offer analgesia and sedation should be a priority in paediatric emergency departments. The aim of this study was to determine the effectiveness and safety of the sedation-analgesia procedure, as well as the satisfaction of the doctors, patients and parents. Methods: A multicentre, observational, and prospective analytical study was conducted on the sedation-analgesia procedure performed on children younger than 18 years old in 18 paediatric emergency departments in Spain from February 2015 until January 2016. Results: A total of 658 procedures were recorded. The effectiveness was good in 483 cases (76.1%; 95% CI: 72.7–79.4%), partial in 138 (21.7%; 95% CI: 18.5–24.9%), and poor in 14 (2.2%; 95% CI: 1.1–3.4). The effectiveness was better when the doctor in charge was an emergency paediatrician (OR: 3.14; 95% CI: 1.10–8.95), and when a deeper level of sedation was achieved (OR: 2.37; 95% CI: 1.68–3.35). Fifty two children (8.4%) developed adverse drug reactions, more usually gastrointestinal, neurological or respiratory ones (89.9% were resolved in

Background: The use of rivaroxaban in clinical practice often deviates from manufacturer prescribing information. No studies have demonstrated an association between this practice and improved outcomes. Methods: We used the RIETE registry to assess the clinical characteristics of patients with pulmonary embolism (PE) who received off-label rivaroxaban, and to compare their 3-month outcomes with those receiving the labeled therapy. The patients were classified into four subgroups: (1) labeled therapy; (2) delayed start; (3) low doses and (4) both conditions. Results: From May 2013 to May 2022, 2490 patients with PE received rivaroxaban: labeled therapy—1485 (58.6%); delayed start—808 (32.5%); low doses—143 (5.7%); both conditions—54 (2.2%). Patients with a delayed start were more likely to present with syncope, hypotension, raised troponin levels and more severe abnormalities on the echocardiogram than those on labeled therapy. Patients receiving low doses were most likely to have cancer, recent bleeding, anemia, thrombocytopenia or renal insufficiency. During the first 3 months, 3 patients developed PE recurrence, 4 had deep-vein thrombosis, 11 had major bleeding and 16 died. The rates of major bleeding (11 vs. 0; p < 0.001) or death (15 vs. 1; OR: 22.5; 95% CI: 2.97–170.5) were higher in patients receiving off-label rivaroxaban than in those on labeled therapy, with no differences in VTE recurrence (OR: 1.11; 95% CI: 0.25–6.57). Conclusions: In patients with severe PE, the start of rivaroxaban administration was often delayed. In those at increased risk for bleeding, it was often prescribed at low doses. Both subgroups had a worse outcome than those on labeled rivaroxaban.

Los microorganismos son de gran interés porque colonizan todo tipo de ambiente, sin embargo, uno de los problemas al que nos enfrentamos para conocer su diversidad biológica es que no todos los microorganismos son cultivables. El desarrollo de nuevas tecnologías como la generación de vectores de clonación aunado al desarrollo de técnicas de secuenciación de alto rendimiento ha favorecido el surgimiento de una nueva herramienta llamada metagenómica, la cual nos permite estudiar genomas de comunidades enteras de microorganismos. Debido a que ningún ambiente es idéntico a otro, es importante mencionar que dependiendo del tipo de muestra a analizar será el tipo de reto al cual nos enfrentaremos al trabajar con metagenómica, en el caso específico del suelo existen diversas variantes como la contaminación del suelo con metales pesados o diversos compuestos químicos que podrían limitar los estudios. Sin embargo, pese a las limitaciones que el mismo ambiente presenta, la metagenómica ha permitido tanto el descubrimiento de nuevos genes como la caracterización de las comunidades microbianas que influyen positivamente en el desarrollo de plantas, lo cual en un futuro podría generar un gran impacto en la agricultura. En este artículo se realizó una revisión de diversas investigaciones que han empleado metagenómica, reportadas en las bases de datos de PudMed y Google Schoolar, con el objetivo de examinar los beneficios y limitaciones de las diversas metodologías empleadas en el tratamiento del ADN metagenómico de suelo y el impacto de la metagenómica en la agricultura.

Nosocomial infections caused by multidrug-resistant (MDR) Klebsiella pneumoniae are a major health problem worldwide. The aim of this study was to describe NDM-1-producing K. pneumoniae strains causing bacteremia in a tertiary referral hospital in Mexico. MDR K. pneumoniae isolates were screened by polymerase chain reaction for the presence of resistance genes. In resistant isolates, plasmids were identified and conjugation assays were performed. Clonal diversity and the sequence types were determined by pulsed-field gel electrophoresis and multilocus sequence typing. A total of 80 K. pneumoniae isolates were collected from patients with bacteremia over a 1-year period. These isolates showed a level of resistance of 59% (47/80) to aztreonam, 56–60% (45–48/80) to cephalosporins, 54% (43/80) to colistin and 12.5% (10/80) to carbapenems. The carbapenem resistant isolates were blaNDM–1 carriers and negative for blaKPC, blaNDM, blaIMP, blaVIM and blaOXA–48–like carbapenemases genes. Conjugative plasmids IncFIIA and IncF group with sizes of 82–195 kbp were carriers of blaNDM–1, blaCTX–M–15, blaTEM–1, aac(6′)-Ib and/or aac(3′)-IIa. Clonal variability and nine different multilocus sequence types were detected (ST661, ST683, ST1395, ST2706, ST252, ST1198, ST690, ST1535, and ST3368) for the first time in the isolates carrying blaNDM–1 in Mexico. This study demonstrates that blaNDM–1 has remained within this hospital in recent years and suggests that it is currently the most prevalent carbapenemase among K. pneumoniae MDR strains causing bacteremia in Mexico. The horizontal transfer of blaNDM–1 gene through IncF-like plasmids among different clones demonstrates the dissemination pathway of antimicrobial resistance and underscore the need for strong and urgent joint measures to control the spread of NDM-1 carbapenemase in the hospital.

Background: The use of low-molecular-weight heparin (LMWH) for long-term therapy of venous thromboembolism (VTE) in patients without cancer has not been consistently evaluated. Methods: We used the data in the RIETE registry to compare the 3-month outcomes (VTE recurrences, major bleeding or death) in non-cancer patients with VTE, according to long-term therapy with LMWH or vitamin K antagonists (VKAs). Results: As of March 2018, 14,582 non-cancer patients with VTE had received initial therapy with LMWH and then switched to VKAs, while 9151 were prescribed LMWH for initial and long-term therapy. Overall, 11,494 had initially presented with pulmonary embolism (PE) and 12,239 with isolated deep vein thrombosis (DVT). Among 11,494 patients initially presenting with PE, 84 had VTE recurrences, 204 major bleeding and 406 died. Among 12,239 patients with isolated DVT, 133 developed VTE recurrences, 137 bled and 289 died. On propensity score analysis, PE patients on long-term LMWH therapy were at increased risk for PE recurrences (OR: 3.30; 95%CI: 1.67–6.48), major bleeding (OR: 1.68; 95%CI: 1.21–2.32) or death (OR: 3.16; 95%CI: 2.43–4.09) compared with those receiving VKAs. In patients with DVT, those on long-term LMWH also were at increased risk for PE recurrences (OR: 2.31; 95%CI: 1.13–4.73), major bleeding (OR 2.28; 95%CI: 1.51–3.44) or death (OR: 2.32; 95%CI: 1.54–3.51). Conclusions: In the RIETE non-cancer patients with VTE, long-term therapy with VKAs was associated with a lower risk for recurrences, major bleeding or death.

Objective: Coronavirus disease 2019 (COVID-19) cases caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to increase worldwide. Although some data from pediatric series are available, more evidence is required, especially in neonates, a group with specific characteristics that deserve special attention. This study aimed to describe general and clinical characteristics, management, and treatment of postnatal-acquired (community and nosocomial/hospital-acquired) COVID-19 neonatal cases in Spain.Methods: This was a national prospective epidemiological study that included cases from a National Registry supported by the Spanish Society of Neonatology. Neonates with postnatal SARS-CoV-2 infection were included in this study. General data and infection-related information (mode and source of transmission, age at diagnosis, clinical manifestations, need for hospitalization, admission unit, treatment administered, and complementary studies performed, hospital stay associated with the infection) were collected.Results: A total of 40 cases, 26 community-acquired and 14 nosocomial were registered. Ten were preterm newborns (2 community-acquired and 8 nosocomial COVID-19 cases). Mothers (in both groups) and healthcare workers (in nosocomial cases) were the main source of infection. Hospital admission was required in 22 community-acquired cases [18 admitted to the neonatal intermediate care unit (NIMCU) and 4 to the neonatal intensive care unit (NICU)]. Among nosocomial COVID-19 cases (n = 14), previously admitted for other reasons, 4 were admitted to the NIMCU and 10 to the NICU. Ten asymptomatic patients were registered (5 in each group). In the remaining cases, clinical manifestations were generally mild in both groups, including upper respiratory airways infection, febrile syndrome or acute gastroenteritis with good overall health. In both groups, most severe cases occurred in preterm neonates or neonates with concomitant pathologies. Most of the cases did not require respiratory support. Hydroxychloroquine was administered to 4 patients in the community-acquired group and to 2 patients in the nosocomial group. Follow-up after hospital discharge was performed in most patients.Conclusions: This is the largest series of COVID-19 neonatal cases in Spain published to date. Although clinical manifestations were generally mild, prevention, treatment, and management in this group are essential.

José Luís Fernández subraya que la radio es un medio diferente, no se han encontrado los límites; es una mediatización que flota, resiste y construye alternativas desde que la tv ocupó un lugar central en la sociedad. Analiza continuidades, el futuro del medio y el impacto que de la pandemia.

Health religious organizations tend to offer individual attention to patients in line with their spiritual character and, at the same time, the highest service quality. This study puts the attention on the nurse-patient relationship and empirically explores a theoretical model that links nurses’ suffering at work with personal’s willingness to engage in a therapeutic and spiritual relationship with patients and the consequent effect on quality. Data has been collected in the city of Madrid (Spain) in the month of June 2019 in Santa Elena Clinic. An analytical case-study based on Partial Least Squares (PLS) path modeling is the chosen method to verify the cause-effect hypothesized relationships. This study contributes to the current academic literature by providing new knowledge and empirical evidence on the topic of the future of work in health religious organizations. The main conclusion is the necessary inclusion of suffering, even in good places to work, as a key indicator for a better management. Results should be a useful source of information for practitioners that seek to implement better human management systems in these organizations.

El objetivo de este artículo es facilitar la interacción con otros escritos que analizan, con los riesgos propios de la contemporaneidad, el discurso del presidente de Argentina, Alberto Fernández, en momentos pandémicos. Se enfocarán dos temas convergentes, pero de relativa independencia. Por un lado, se mostrará un modo de trabajo de análisis de las mediatizaciones presidenciales, que no se deposite en la palabra individual de quien ocupa un cargo y, por el otro, se describirá desde ese punto de vista, la performance presidencial en sus relaciones con diversos actores de la comunicación pública y con diferentes sistemas de intercambio. Se describirán aspectos del contexto mediático de la época, rasgos centrales los modos de comunicación presidencial previos al actual, el intertexto mediático y pandémico en el que toma la palabra el presidente argentino y qué fuerzas y debilidades se pueden describir. Las propuestas de alternativas de comunicación, no se harán con el fin de conseguir adhesiones sino para mostrar modos de trabajo que generen posibilidades de innovación.

La investigación sobre diversas plataformas multimediáticas nos va ampliando el horizonte sobre la circulación de los discursos mediatizados. Tienden a verse, en nuestro trabajo, como procesos de circulación, tanto los fenómenos de las cookies, como los resultados de los ARS (análisis de redes sociales), y tanto fenómenos de recorridos a través de redes, como a las publicaciones sobre el big-data de las plataformas. En este artículo, se presenta el estado actual del trabajo del equipo sobre esos procesos de circulación.