1. Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D
- Author
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Montserrat Torres, Guiomar Casado, Lorena Vigón, Sara Rodríguez-Mora, Elena Mateos, Fernando Ramos-Martín, Daniel López-Wolf, José Sanz-Moreno, Pablo Ryan-Murua, María Luisa Taboada-Martínez, María Rosa López-Huertas, Miguel Cervero, Mayte Coiras, David Alonso-Menchén, Sandra Arévalo Camacho, Cristina Avila Calzada, José Antonio Barbado Albaladejo, Natalia Blanca López, Irene Cañamares Orbis, Gema Carrillo Blanco, Almudena Cascajero Díaz, María Teresa Chica Burguillo, Ana Corrochano García, Sara Corredera García, Victor Díez Viñas, Marta Gómez-Alvarez Domínguez, Claudia Patricia Fernández Fernández, Yanira Fernández Mondelo, Eva Fonseca Aizpuri, Concepción García Lacalle, Javier García-Pérez, Cristina Helguera Amezua, Francisco José Hidalgo Correas, Amparo Lucena Campillo, Mariano Matarranz del Amo, Oriol Martín Sagarra, Emilio José Martínez Martín, José Javier Martínez Simón, María Novella-Mena, Virginia Pardo Guimera, María Luisa Pinillos Pardo, Fr`ancisca Ramírez Fuentes, Daniel Renuncio García, María Angeles Rodríguez Dávila, Almudena Roger Revilla, Lourdes Sampablo Valverde, José Sanz Moreno, Rafael Torres Perea, Jorge Valencia La Rosa, María Velasco Arribas, and Ana Villanueva Fernández-Ardavín
- Subjects
COVID-19 ,SARS-CoV-2 ,Vitamin D supplementation ,Immune cytotoxic response ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Main cause of severe illness and death in COVID-19 patients appears to be an excessive but ineffectual inflammatory immune response that may cause severe acute respiratory distress syndrome (ARDS). Vitamin D may favour an anti-inflammatory environment and improve cytotoxic response against some infectious diseases. A multicenter, single-blind, prospective, randomized clinical trial was approved in patients with COVID-19 pneumonia and levels of 25-hydroxyvitamin D (25(OH)D) of 14.8 ng/ml (SD: 6.18) to test antiviral efficacy, tolerance and safety of 10,000 IU/day of cholecalciferol (vitamin D3) for 14 days, in comparison with 2000 IU/day. After supplementation, mean serum 25(OH)D levels increased to 19 ng/ml on average in 2000 IU/day versus 29 ng/ml in 10,000 IU/day group (p
- Published
- 2022
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