1. Immunohistochemical profile of stromal constituents and lymphoid cells over the course of wound healing in murine model
- Author
-
Bernadeth Moda de Almeida, Marismar Fernandes do Nascimento, Rose Nely Pereira-Filho, Genecy Calado de Melo, José Cleveilton dos Santos, Clauberto Rodrigues de Oliveira, Margarete Zanardo Gomes, Sônia Oliveira Lima, and Ricardo Luiz Cavalcanti de Albuquerque-Júnior
- Subjects
Wound Healing ,Immunohistochemistry ,Histological Techniques ,Rats, Wistar ,Surgery ,RD1-811 - Abstract
PURPOSE:To assess the evolution profile of the immunohistochemical expression of stromal constituents over the time-course of wound healing in a murine model.METHODS: Surgical wounds were performed in the back of 24 Wistar rats. After three, seven, 14 and 21 days, six rats were euthanized and the wounded histologically processed to assess the immunohistochemical expression of CD3, CD20, CD31, α-SMA and type-I collagen. Non-injured skin samples (NSS) were used as control. Data were subjected to statistical analysis using ANOVA and Tukey test.RESULTS: The mean of CD3 and CD20 positive cells in the wounds was significantly higher than in NSS at seven and 14 days (p
- Published
- 2014
- Full Text
- View/download PDF