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IntroductionData on medulloblastoma outcomes and experiences in low- and middle-income countries, especially in Latin America, is limited. This study examines challenges in Mexico’s healthcare system, focusing on assessing outcomes for children with medulloblastoma in a tertiary care setting.MethodsA retrospective analysis was conducted, involving 284 patients treated at 21 pediatric oncology centers in Mexico.ResultsHigh-risk patients exhibited markedly lower event-free survival than standard-risk patients (43.5% vs. 78.3%, p1.5cm², and lower radiotherapy doses significantly impacted event-free survival (EFS) and overall survival (OS). Platinum-based chemotherapy showed better results compared to the ICE protocol in terms of OS and EFS, which was associated with higher toxicity. Patients under 3 years old displayed notably lower OS and EFS compared to older children (36.1% vs. 55.9%, p=0.01).

The essential oil industry is a growing sector that generates 5.41 billion USD annually worldwide. Essential oils are widely used in medicine, agriculture, and perfumery. Although there are available systems in the market for domestic essential oil extraction, replacing the entire equipment in case of repair or malfunction can be costly. To address this problem, a pilot-scale essential oil extractor system was developed that operates through hydrodistillation. This system was used to process various citrus wastes such as green and yellow lemons, oranges, grapefruits, and Eucalyptus globulus. A factorial design was performed, and the best conditions were used to extract other biomass residues. GC-MS analysis revealed that the primary compound for orange, grapefruit, and green lemon essential oils is D-imonene, with 95.4%, 95.5%, and 49.2%, respectively. For yellow lemon the primary compound appeared to be D-limonene with 73.0% content, though the GC/MS data were less clear, and for eucalyptus, it is eucalyptol with 71.0%. The estimated production costs were 0.01 USD/mL, 0.04 USD/mL, 0.06 USD/mL, 0.07 USD/mL, and 0.15 USD/mL for orange, grapefruit, green lemon, yellow lemon, and eucalyptus essential oils, respectively. Therefore, the developed system is a competitive option for pilot-scale essential oil extraction.

The aim of the present study was to examine effects of relevance instructions and elaborative interrogation on the processing of and memory for expository texts. Eye movements of 132 undergraduate students were tracked while they read expository texts. After reading each text, they produced an oral summary. Participants were divided into four experimental conditions that differed by the presence or absence of the why question and the specific or general relevance instruction they received. Results showed that readers who received the why question embedded in the texts and also received the specific instruction of answering the question demonstrated more strategic reading, as reflected in their first-pass and look-back reading times and also in their better recall of question-relevant information. These results can be readily applied to real-life learning contexts, as they suggest that employing specific relevance instructions in combination with elaborative interrogation may elicit more efficient and strategic reading.

The ability of multifunctional food-derived peptides to act on different body targets make them promising alternatives in the prevention/management of chronic disorders. The potential of Erythrina edulis (pajuro) protein as a source of multifunctional peptides was proven. Fourteen selected synthetic peptides identified in an alcalase hydrolyzate from pajuro protein showed in vitro antioxidant, anti-hypertensive, anti-diabetic, and/or anti-obesity effects. The radical scavenging properties of the peptides could be responsible for the potent protective effects observed against the oxidative damage caused by FeSO4 in neuroblastoma cells. Moreover, their affinity towards the binding cavity of angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) were predicted by molecular modeling. The results demonstrated that some peptides such as YPSY exhibited promising binding at both enzymes, supporting the role of pajuro protein as a novel ingredient of functional foods or nutraceuticals for prevention/management of oxidative stress, hypertension, and metabolic-alteration-associated chronic diseases.

Theories about visual narrative understanding accentuate the difference between patterns of reading comprehension in children and adults when they read text and images. This study was conducted to explore the differences in eye movement patterns when children and adults read different comic stories using a coherence/incoherence paradigm. A total of 63 participants, 31 children (10-12 years old) and 32 undergraduate university students from the Universidad Autónoma de Madrid, read 20 comic stories, each of them with both coherent and incoherent versions, for the two ending frames. Fixation durations, number of fixations, and number of regressions were recorded by an eye-tracker, Tobii x-120. A crossed random effects model was applied. Results showed that even though children reach a similar level of understanding than adults they spend more time and have longer fixations than adults, showing more effort to reach the whole comprehension of the stories. Besides, results do not detect significant differences between eye movements’ patterns in peak and release for the two groups studied, and therefore both components of the visual narrative grammar are considered equally relevant in the understanding of comics.

El objetivo de este estudio consistió en evaluar la efectividad de un programa de intervención en español, LEE comprensivamente, para mejorar la comprensión lectora. El programa de intervención se basó en la enseñanza explícita de habilidades de alto nivel vinculadas al procesamiento del texto (construcción de inferencias, control metacognitivo y conocimiento de la estructura textual) y de bajo nivel (vocabulario). El programa consistió en 16 sesiones de 80 minutos durante 8 semanas. Un total de 127 niños de entre 8 y10 años de diferentes escuelas de Buenos Aires se distribuyeron en dos grupos, experimental y control. Los procesos evaluados incluyeron medidas generales de comprensión lectora y específicas, de vocabulario, control metacognitivo e inferencias, antes y después de la intervención. Solo el grupo que recibió la intervención mostró mejoras estadísticamente significativas en la comprensión lectora frente al grupo control. Estos hallazgos sugieren que la intervención centrada en los ejes descritos mejora significativamente la comprensión lectora de los niños dentro de la escuela.

Exergy and energy analyses of two biodiesel production processes that integrate solar energy as the main energy source were developed to determine the process with the higher efficiency from an energy and exergy approach. The biodiesel production processes were simulated in ASPEN PLUS®, and the solar energy supply was studied in TRNSYS®, using EXCEL® simultaneously for the exergetic analysis. The solar thermal energy collection system can supply 81% of the energy required by the alkali process in the Flash separation equipment. For the supercritical process, solar thermal energy can supply 74.5% of the energy in the preheating and separation stages. The energy efficiency of the supercritical process is higher; nevertheless, the exergetic efficiency of the alkaline process is higher than the supercritical one. Solar collection systems contribute from 85% to 93% of the exergy destroyed by the global process for both cases. The alkaline biodiesel production process has the highest advantages when using solar energy as the main source of energy, compared to a process in supercritical conditions that presents greater irreversibilities and requires more infrastructure to collect the solar resource. However, using solar energy as the foremost energy source offers an alternative to fossil fuels, and it provides an environmental benefit concurrently with the use of biodiesel.

Comprehension and summarizing are closely related. As more strategic and selective processing during reading should be reflected in higher quality of summaries, the aim of this study was to use eye movement patterns to analyze how readers who produce good quality summaries process texts. 40 undergraduate students were instructed to read six expository texts in order to respond a causal question introduced in the end of the first paragraph. After reading, participants produced an oral summary of the text. Based on the quality of the summaries, participants were divided into three groups: High, Medium and Low Quality Summaries. The results revealed that readers who produced High Quality Summaries made significantly more and longer fixations and regressions in the question-relevant parts of texts when compared to the other two summary groups. These results suggest that the summary task performance could be a good predictor of the reading strategies utilized during reading.

Annually, millions of tons of foods are generated with the purpose to feed the growing world population. One particular eatable is orange, the production of which in 2018 was 75.54 Mt. One way to valorize the orange residue is to produce bioethanol by fermenting the reducing sugars generated from orange peel. Hence, the objective of the present work was to determine the experimental conditions to obtain the maximum yield of reducing sugars from orange peel using a diluted acid hydrolysis process. A proximate and chemical analysis of the orange peel were conducted. For the hydrolysis, two factorial designs were prepared to measure the glucose and fructose concentration with the 3,5-DNS acid method and UV-Visible spectroscopy. The factors were acid concentration, temperature and hydrolysis time. After the hydrolysis, the orange peel samples were subjected to an elemental SEM-EDS analysis. The results for the orange peel were 73.530% of moisture, 99.261% of volatiles, 0.052% of ash, 0.687% of fixed carbon, 19.801% of lignin, 69.096% of cellulose and 9.015% of hemicellulose. The highest concentration of glucose and fructose were 24.585 and 9.709 g/L, respectively. The results highlight that sugar production is increased by decreasing the acid concentration.

Abstract Idiopathic Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. Magnetic Resonance-guided high-intensity focused ultrasound (MRgFUS) of the subthalamic nucleus (STN) is gaining recognition as a minimally invasive surgical option. This study assesses the safety and efficacy of unilateral MRgFUS subthalamotomy, aiming to create the smallest effective lesion. Between June 2021 and October 2023, twelve PD patients underwent the procedure, with primary outcomes focused on safety and motor improvements after six months. Results indicated significant motor improvements, with over 50% reduction in tremor, rigidity, and bradykinesia, while balance and gait remained stable. Quality of life also improved. Side effects were generally mild and transient, though some patients experienced involuntary movements, managed through medication adjustments. Despite limitations, this technique appears to offer a promising, less-invasive alternative for managing PD symptoms with a favorable risk-benefit profile. Further research is necessary to refine the procedure and assess long-term outcomes.

The white-elitist veganism of the Global North does not adequately respond to the territorial, cultural, and economic particularities of the Latin American region. This article discusses the approaches of animal rights activists from the South and their critical handling of the animal question, which challenges the neocolonial and universalising logics characteristic of hegemonic animal advocacy. It seeks to explain empirically the composition of popular and decolonial styles of veganism in Latin America, using a qualitative methodology to analyse the life stories of Luis, Luz and Puka, indigenous animal rights activists from Ecuador and Peru. Thus, it describes the subjectivities of popular veganism which, sharing the wound of colonialism, develop critical decolonial discourses and practices that affirm the principles of the Andean cosmovision of Buen Vivir - Good Living, the return to the “chakra”, respect for the living, the recovery of ancestral memory, and the defence of territorial food sovereignty.

In recent years, research on noncatalytic methods for biodiesel production has increased, mainly processes under supercritical conditions that allow the processing of waste vegetable oils (WVO) without the need to use catalysts, where the absence of catalyst simplifies the processes of purification of biodiesel. The high consumption of alcohol and energy to maintain the appropriate conditions of pressure and temperature of the reaction has turned the processes of supercritical conditions into an unfeasible method. However, the stages of biodiesel purification and methanol recovery are more straightforward, allowing the reduction of the total energy consumption by 25% compared to alkaline methods. Therefore, the present work describes a study through Aspen Plus® of the production of biodiesel by a process in supercritical conditions with WVO as raw material. Also, a solar collector arrangement was structured using the TRNSYS® simulator to supply energy to the process. To evaluate the economic feasibility of the proposed process, the installation of a pilot plant in Mexicali, Baja California, was considered. The internal rate of return (IRR) and the net present value (NPV) were determined for ten-year period. The planned system allows supplying solar energy, 69.5% of the energy required by the process, thus reducing the burning of fossil fuels and the operation cost. Despite the additional investment cost, for the solar collectors, the process manages to maintain a competitive production cost of USD 0.778/l of biodiesel. With an IRR of 31.7%, the investment is recovered before the fifth year of operation. The integration and implementation of clean technologies are vital in the development of the biofuels.

El objetivo del estudio fue el de mostrar evidencias de fiabilidad y validez para una prueba de resúmenes (RESUMev) que evalúa el grado de comprensión lectora en alumnos de cuarto y sexto de primaria. Participaron un total de 528 estudiantes de primaria, de los cuales 236 fueron estudiantes de 4º de primaria (9 y 10 años) y 292 a 6º de primaria (11 a 13 años). Todos estos alumnos procedían de 21 centros escolares. Para evaluar la consistencia interna, se calculó el alfa de Cronbach en los criterios de evaluación de resúmenes (contenido, coherencia y estilo) y su índice de homogeneidad (Hj ). La validez se evaluó mediante la comparación entre niveles académicos. En cuanto a los resultados, se obtuvieron índices elevados significativos de fiabilidad y de validez. Los resultados proporcionan evidencia empírica para la validez de la prueba.

In this work, the antioxidant properties of methanolic extract of Larrea tridentata were assessed through the free radical scavenging method, ferric reducing antioxidant power and oxygen radical absorbance capacity. The phenolic acids content in the extract was quantified by high-performance liquid chromatography (HPLC) and the total phenol content by the Folin−Ciocalteu method. The extract was used as an antioxidant in biodiesel from canola oil composed mostly by fatty acid methyl esters identified and quantified by gas chromatography-mass spectrophotometry (GC-MS). The performance of the extract as an antioxidant was assessed by the oxidative stability index (OSI) with a Rancimat equipment at 100, 110, 120 and 130 °C. Additionally, the change of the peroxide value (PV) and the higher heating value under conditions of oxidative stress at 100 °C and air injection were measured. The antioxidant capacity of the extract reached 50,000 TAEC (micromole of Trolox antioxidant equivalent capacity per gram). The biodiesel was constituted by more than 70% of unsaturated fatty acid methyl esters (FAME), mainly methyl oleate. The time needed to reach a PV of 100 meqO2/kg was almost four times longer with an antioxidant concentration of 250 mg/L than the blank. The biodiesel showed an OSI time of 1.25 h at 110 °C, while it increased to 8.8, 15.89 and 32.27 h with the antioxidant at concentrations of 250, 500 and 1000 mg/L, respectively. The methanolic Larrea tridentata extract proved to have an antioxidant capacity and it is a green antioxidant in biodiesel to increase its oxidative stability. According to the results obtained, the L. tridentata methanolic extract is an alternative to the commercial synthetic antioxidants used in biodiesel nowadays.

The main objective of this study is to calculate the structure of a network of elements of life satisfaction and emotional well-being in young Peruvians, through network analysis, using the Satisfaction with Life Scale (SWLS) and the Well-Being Index WHO-5. A total of 414 university students between the ages of 18 and 27 (M = 22.18; SD = 2.57) participated. The results show that network analysis offers new avenues for exploring the dimensionality of complex constructs, concluding that the SWLS and WHO-5 represent distinct but related dimensions of subjective well-being. In addition, the items linked to the global judgement of satisfaction with one’s own life and with the activation of the arousal level stand out for their relevance in the network. Finally, some differences in network connectivity according to sex are highlighted, which merit further research.

Recent research and development of clean energy have become essential due to the global climate change problem, which is caused largely by fossil fuels burning. Therefore, biodiesel, a renewable and ecofriendly biofuel with less environmental impact than diesel, continues expanding worldwide. The process for biodiesel production involves a significant energy demand, specifically in the methanol recovery stage through a flash separator and a distillation column. Traditionally, the energy required for this process is supplied by fossil fuels. It represents an opportunity for the application of renewable energy. Hence, the current study presents a system of thermal energy storage modeled in TRNSYS® and supported by simulations performed in ASPEN PLUS®. The aim of this research was to supply solar energy for a methanol recovery stage in a biodiesel production process. The results highlighted that it is feasible to meet 91% of the energy demand with an array of 9 parabolic trough collectors. The array obtained from the simulation was 3 in series and 3 in parallel, with a total area of 118.8 m2. It represents an energy saving of 70 MWh per year.

Este trabajo revisa los resultados de 31 estudios que evalúan de alguna forma la "alteración de la imagen corporal" en anorexia nerviosa y bulimia nerviosa a través de los métodos de evaluación perceptiva o los métodos de evaluación actitudinal. Los estudios presentan en la mayoría de los casos resultados contradictorios entre ellos. Los autores ofrecen una serie de explicaciones metodológicas y meta-analíticas para tratar de interpretar los resultados.

En este artículo se presentan algunas de las principales conclusiones con aplicación en el ámbito educativo que se pueden extraer a partir de la literatura sobre la interacción entre preguntas y respuestas. Por una parte, se realiza una revisión de las investigaciones realizadas desde la psicología básica que permite conocer de forma resumida el estado de la cuestión, así como algunos de los factores reguladores de esta interacción y los tipos de preguntas que pueden generarse. Por otra parte, se presentan algunos ejemplos de investigaciones más aplicadas, con clara orientación pedagógica. El artículo termina con una serie de sugerencias extraídas a partir de la literatura que, de nuevo, pretenden ayudar a los docentes en su práctica diaria.

En este artículo abordaremos algunas de estas cuestiones relativas a las estrechas relaciones entre mente y cerebro, no sin antes detenernos en saber algo más de las inferencias responsables de todo el lenguaje implícito que media en los procesos de comprensión y la realización de inferencias. El artículo introduce, aunque sea de manera breve, en este mundo fascinante del estudio del lenguaje implícito y de sus implicaciones en la mente y el cerebro, así como algunos resultados obtenido con la resonancia magnética funcional (RMf) y sobre algunas de sus repercusiones en el estudio del lenguaje e implicaciones educativas.

La concepción actual de la competencia lectora se ha modificado extraordinariamente durante las últimas décadas. Más que asumirse dentro de la etapa inicial de la adquisición lectora, el estudio de la lectura afecta a todo el ciclo vital. En este trabajo se analiza esta nueva concepción de la competencia lectora basada en los tipos y niveles de conocimiento, y se plantean algunas cuestiones relativas a la función del psicólogo dentro de este nuevo planteamiento.

Genetic diversity and demographic parameters were computed to evaluate the historic effects of coat colour segregation in the process of configuration of the Hispano-Arabian horse (Há). Pedigree records from 207,100 individuals born between 1884 and 2019 were used. Although coat colour is not a determinant for the admission of Hispano-Arabian individuals as apt for breeding, it may provide a representative visual insight into the gene contribution of Spanish Purebred horses (PRE), given many of the dilution genes described in Há are not present in the Arabian Purebred breed (PRá). The lack of consideration of coat colour inheritance patterns by the entities in charge of individual registration and the dodging behaviour of breeders towards the historic banning policies, may have acted as a buffer for diversity loss (lower than 8%). Inbreeding levels ranged from 1.81% in smokey cream horses to 8.80 for white horses. Contextually, crossbred breeding may increase the likelihood for double dilute combinations to occur as denoted by the increased number of Há horses displaying Pearl coats (53 Há against 3 PRE and 0 PRá). Bans against certain coat colours and patterns may have prevented an appropriate registration of genealogical information from the 4th generation onwards for decades. This may have brought about the elongation of generation intervals. Breeder tastes may have returned to the formerly officially-recognised coat colours (Grey and Bay) and Chestnut/Sorrel. However, coat colour conditioning effects must be evaluated timely for relatively short specific periods, as these may describe cyclic patterns already described in owners' and breeders' tastes over the centuries.

Thunderstorms are known to have the potential to cause damage to the population. In Mexico, these weather events can bring threats such as lightning, hail, damaging winds, and even tornadoes. Various parameters and indices have been developed for mid-latitude regions to improve forecasting and reduce the potential damage from thunderstorms; however, they do not consider the specific conditions of tropical and subtropical environments. This research used a comprehensive set of thunderstorm reports and the proximity-sounding approach using ERA5 reanalysis data to examine five important instability indices commonly used for thunderstorm forecasting regarding their spatial and temporal characteristics. The results reveal significant variations in the values of the instability indices during thunderstorm events associated with different atmospheric systems in both the high-activity and low-activity seasons. The above suggests that no single index can reliably predict thunderstorms throughout Mexico and during all seasons. Analyses provide forecasters with a more comprehensive understanding of the various atmospheric conditions under which thunderstorms develop in the country, which can lead to more accurate forecasting and better disaster risk management for these natural phenomena.

Genetic diversity and population structure were analyzed using the historical and current pedigree information of the Arabian (PRá), Spanish Purebred (PRE), and Hispano-Arabian (Há) horse breeds. Genetic diversity parameters were computed and a canonical discriminant analysis was used to determine the contributions of ancestor breeds to the genetic diversity of the Há horse. Pedigree records were available for 207,100 animals born between 1884 and 2019. Nei's distances and the equivalent subpopulations number indicated the existence of a highly structured, integrated population for the Há breed, which is more closely genetically related to PRá than PRE horses. An increase in the length of the generation interval might be an effective solution to reduce the increase in inbreeding found in the studied breeds (8.44%, 8.50%, and 2.89%, for PRá, PRE, and Há, respectively). Wright's fixation statistics indicated slight interherd inbreeding. Pedigree completeness suggested genetic parameters were highly reliable. High GCI levels found for number of founders and non-founders and their relationship to the evolution of inbreeding permit controlling potential deleterious negative effects from excessively frequent mating between interrelated individuals. For instance, the use of individuals presenting high GCI may balance founders' gene contributions and consequently preserve genetic diversity levels (current genetic diversity loss in PRá, PRE, and Há is 6%, 7%, and 4%, respectively).

Scientific evidence for intelligence in donkeys could expose their historical unmerited cognitive derogatory status. Psychometric testing enables quantifying animal cognitive capabilities and their genetic background. Owing to the impossibility to use the language-dependent scales that are widely used to measure intelligence in humans, we used a nonverbal operant-conditioning problem-solving test to compute a human-analogous IQ, scoring the information of thirteen cognitive processes from 300 genetically tested donkeys. Principal components and Bayesian analyses were used to compute the variation in cognitive capabilities explained by the cognitive processes tested and their genetic parameters, respectively. According to our results, IQ may explain over 62% of the cognitive variance, and 0.06 to 0.38 heritabilities suggest that we could ascribe a significant proportion to interacting genes describing the same patterns previously reported for humans and other animal species. Our results address the existence of a human-analogous heritable component and mechanisms underneath intelligence and cognition in probably one of the most traditionally misunderstood species from a cognitive perspective.