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Abstract Biased estimates of population status are a pervasive conservation problem. This problem has plagued assessments of commercial exploitation of marine species and can threaten the sustainability of both populations and fisheries. We develop a computer‐intensive approach to minimize adverse effects of persistent estimation bias in assessments by optimizing operational harvest measures (harvest control rules) with closed‐loop simulation of resource‐management feedback systems: management strategy evaluation. Using saithe (Pollachius virens), a bottom water, apex predator in the North Sea, as a real‐world case study, we illustrate the approach by first diagnosing robustness of the existing harvest control rule and then optimizing it through propagation of biases (overestimated stock abundance and underestimated fishing pressure) along with select process and observation uncertainties. Analyses showed that severe biases lead to overly optimistic catch limits and then progressively magnify the amplitude of catch fluctuation, thereby posing unacceptably high overharvest risks. Consistent performance of management strategies to conserve the resource can be achieved by developing more robust control rules. These rules explicitly account for estimation bias through a computational grid search for a set of control parameters (threshold abundance that triggers management action, Btrigger, and target exploitation rate, Ftarget) that maximize yield while keeping stock abundance above a precautionary level. When the biases become too severe, optimized control parameters—for saithe, raising Btrigger and lowering Ftarget—would safeguard against a overharvest risk (

Abstract Background Mesenchymal stem cell infusion and vitamin D supplementation may have immunomodulatory actions that could prolong the preservation of residual insulin secretion in patients with type 1 diabetes (T1D). Intervention with these agents after onset of T1D could favor the development of a remission phase, with potential clinical impact. We aimed to compare the presence of clinical remission (CR), glycemic control and daily insulin requirement at 6, 12, 18, 24 and 36 months after the diagnosis of T1D using IDAA1c in patients who received therapy with adipose tissue-derived mesenchymal stem cell (ASC) infusion and vitamin D supplementation and a control group. Methods: This retrospective cohort study analyzed data from the medical records of patients with T1D diagnosed between 15 and 40 years. Partial CR was defined as an IDAA1c index

Abstract This study evaluates the effects of a green tea (Camellia sinensis) and hyaluronic acid gel on fibroblast activity and alveolar bone repair following third molar extractions. By examining the gene expression related to cell survival, proliferation, and angiogenesis, the study bridges in vitro findings with clinical outcomes in a split-mouth randomized trial. Human fibroblasts were exposed to the treatment gel, analysing gene expression through RT-qPCR. Twenty participants undergoing bilateral third molar extractions received the test gel on one side and a placebo on the other. Assessments included patient-reported outcomes, professional evaluations, and radiographic analyses at multiple postoperative intervals. The test gel significantly enhanced AKT, CDKs, and VEGF gene expressions, indicating a positive effect on angiogenesis and cell proliferation. Clinically, it resulted in reduced exudate, swelling, and secondary interventions, with radiographs showing improved alveolar bone density after 90 days. The green tea and hyaluronic acid gel significantly improves soft tissue and bone healing post-extraction, offering a promising adjunctive therapy for enhancing postoperative recovery. This gel represents a novel adjuvant treatment option for facilitating improved healing outcomes after third molar extractions, highlighting its potential utility in clinical dental practice.

Abstract Introduction The maintenance of oral health in inpatients is essential, particularly to avoid complications arising from periodontal disease, which not only affect oral health but can also exacerbate systemic issues during hospitalization. Objective: This study aimed to assess nursing staff’s knowledge regarding the management of periodontal disease and its association with systemic diseases. Material and method This cross-sectional observational study was conducted in a general referral hospital of the Brazilian National Health System (SUS). A total of 504 nursing professionals completed a self-administered 24-item questionnaire on relating to oral care procedures and the importance of oral health in hospitalized patients. Data were analyzed using descriptive analysis and the chi-squared test (α = 0.05). Result Most respondents (97.8%) believed that oral infections can affect a patient's general health and that oral hygiene is important during hospitalization. However, knowledge deficits were identified. The oral effect of periodontal disease was considered moderate by 49.3% of the participants, and 74.6% believed that sugar was the most common cause of periodontal disease. Conclusion Nursing professionals are aware of the importance of maintaining oral hygiene and the relationship between periodontal and systemic diseases. However, their dental hygiene practice knowledge is limited. A training program on oral healthcare for inpatients and the inclusion of oral hygiene topics in the curricula of nursing professionals are recommended.

Abstract Natural products have been studied as potential anthelmintic drugs. This study aimed to evaluate the effects of the polypeptides/proteins exuded from Mimosa caesalpiniifolia mature seeds on the model nematode Caenorhabditis elegans. After seed immersion for 24 h at 25 ºC in sodium phosphate buffer, pH 7.0, containing 0.15 M NaCl and 1.0 M MgSO4, the constituent polypeptides/proteins were fractionated using ammonium sulfate precipitation followed by ultrafiltration and their effects on C. elegans motility were assessed. Moreover, we evaluated by Atomic Force Microscopy (AFM) whether exposition of the nematode to the polypeptide fraction McSEX10-2 could cause any alteration on the animal’s external surface (cuticle). The whole seed exudates (SEX) from the M. caesalpiniifolia mature seeds (named McSEX) and its polypeptide/protein derived fractions, termed McSEX90%/80°C, McSEX30-10, and McSEX10-2, inhibited the C. elegans motility with an IC50 of 15.18, 12.59, 9.74 and 1.34 μg mL-1.The McSEX10-2 fraction, which encompassed the polypeptides with the molecular mass varying from 10 kDa to 2 kDa, was the most effective. In addition, McSEX10-2 altered the ultrastructure and the mechanical properties of the C. elegans cuticle. McSEX10-2, in particular, can be used as a model to bioinspire structure-based design of new peptides that could control, alone or in combination with other drugs, economically important parasitic nematodes.

High rates of limestone have been increasingly utilized in newly converted areas for grain production in agricultural frontier regions to expedite the short-term correction of soil fertility, leading to compensatory yields. However, there is a lack of information about different doses of lime and gypsum for soils in the Cerrado of Matopiba, especially in the state of Piauí, Brazil. The aim of this study was to evaluate the effects of doses of lime and gypsum in newly converted areas for soybean production in the Cerrado of Southwest Piauí. The study was carried out in the 2019/2020 and 2020/2021 crop years, on yellow Oxisol soil, in a randomized block design and treatments following a 5 × 4 factorial: five lime rates (0, 5, 10, 15, and 20 t ha−1) and four gypsum rates (0, 1, 2 and 4 t ha−1), with four replicates. The standard lime and gypsum rates were 5 t ha−1 and 1 t ha−1, respectively. Soil fertility attributes (0.0–0.2, 0.2–0.4, and 0.4–0.6 m), nutritional status of plants, and soybean yield were measured. The increases in grain yield using a lime rate of 10 t ha−1 were 18% and 12% in the 2019/2020 and 2020/2021 crop years, respectively. High lime rates provide a reduction in the concentrations of P, K, and cationic micronutrients in soil, thereby reducing leaf contents of macro- and micronutrients in soybean plants. Concentrations of Ca, Mg, and S in subsurface layers were raised to proper levels, similar to those recommended for topsoil (0.0–0.2 m). The use of gypsum and lime in newly converted areas for soybean cultivation provides quick improvement in soil chemical conditions and reduction in acidity components. The application of 10 t ha−1 of lime improved the soil chemical environment in the Matopiba region the short time available for chemical reactions to occur, allowing soybean cultivation in newly converted areas of Cerrado into agriculture.

Conservation systems involving trees enhance the sustainability of tropical soils. However, little is known on the effect of integrated systems with native and exotic trees on soil chemical quality in the eastern Amazon. We aimed to measure changes in soil chemical quality in integrated production systems in Pindaré-Mirim, Maranhão, Brazil. This study was carried out in 2017 and 2018, evaluating (i) perennial pasture; (ii) crop–livestock–forest integration-I (CLFI-I)—eucalyptus rows interspersed with maize + Urochloa brizantha intercropping; (iii) CLFI-II—babassu palm trees (Attalea speciosa Mart.) with maize + Megathyrsus maximus intercropping; and (iv) maize + M. maximus intercropping. Soil chemical attributes at depths of 0.00–0.10 m, 0.10–0.20 m, 0.20–0.30 m, and 0.30–0.50 m, forage productivity, and soil cover were evaluated. CLFI-II promoted the highest soil organic matter concentration in topsoil and highest pH, lowest Al3+ levels, and potential acidity (H+Al) at all soil depths. Soil under pasture showed the highest N, K+, Ca2+ concentrations, sum of bases, and cation exchange capacity. Changes in CLFI-II are associated with the babassu palm’s ability to modulate the surrounding environment, giving the species a competitive advantage in anthropic environments. The time of adoption is crucial for improving soil fertility in the Brazilian eastern Amazon. Sustainable production systems in the region must comply with long-term management plans.

Abstract Phosphorus (P) is one of the main nutrients capable of increasing yields of tropical grasses. The definition of adequate P fertilizer rates can contribute to improving forage production of pastures. However, the efficiency in the response of different genotypes of Urochloa mosambicensis (Hack.) Dandy (Bushveld herringbone grass) to P fertilizer rates is not known. This study aimed to quantify the response of U. mosambicensis genotypes to P fertilizer levels and classify the genotypes as to efficiency and responsiveness. The experiment was carried out in pots, under controlled conditions, in a completely randomized design, in a 2 x 9 factorial with five replications. The factors consisted of equivalent P rates of 10 and 90 kg ha-1 of P2O5 (triple superphosphate) and eight genotypes of U. mosambicensis (UmCO-1 (2), UmCO-2 (2), UmCO-4 (1), UmCO-8 (1), UmCO-11 (2), UmCO-12 (2), UmCO-13 (2) and UmCO-14 (2)), in addition to a control, Urochloa brizantha syn. Brachiaria brizantha cv. BRS Piatã. Each experimental unit consisted of one pot. Biometric attributes and dry mass yield were evaluated over four cutting cycles. There was no effect of the P fertilization x genotypes interaction for the variables evaluated. However, the highest fertilizer rate increased dry mass yield and tiller population density in all genotypes and cuttings evaluated. The genotype UmCO-4 (1) and the cultivar BRS Piatã proved to be responsive to and efficient in P use. The highest P rate promoted greatest production of dry mass and greatest number of tillers in all genotypes of U. mosambicensis.

A tipologia psicológica junguiana possibilita constatar características predominantes em cada indivíduo a partir da identificação de sua atitude (introversão ou extroversão) e função (pensamento, sentimento, sensação e intuição) psíquica mais prevalente, distinguindo até 8 tipos psicológicos. O Myers–Briggs Type Indicator (MBTI), uma ampliação da tipologia junguiana, possibilita tipificar os indivíduos em até 16 tipos psicológicos distintos, pela inclusão da função secundária. Inventários baseados no MBTI são amplamente utilizados na área organizacional por todo o mundo. Desse modo, este trabalho teve por objetivo investigar a viabilidade do uso de um instrumento tipológico baseado no MBTI, durante o período de Seleção Complementar do Exército Brasileiro, com a finalidade de viabilizar uma distribuição dos conscritos, entre os cargos e função de uma Organização Militar, considerando-se suas características predominantes, ou seja, potencialidades (pontos fortes e oportunidades de melhoria). Dessa maneira, almeja-se obter um melhor desempenho na execução das atribuições inerentes a esses cargos e funções. Chegou-se à conclusão da viabilidade do uso desse tipo de inventário tipológico durante o período de seleção complementar do alistamento militar, contudo, constatou-se a necessidade de se usar, anteriormente, um inventário para realizar o levantamento de quais são os tipos psicológicos mais adequados para cada cargo e função. O uso dos inventários possibilita agregar uma metodologia, com fundamentação científica, a essa atividade de seleção complementar, contribuindo para melhoria na qualidade da distribuição dos indivíduos nos cargos e funções disponíveis no corpo de tropa.

Este estudo teórico-empírico tem como objetivo mapear as características culturais dos brasileiros que compõem a amostra analisada, com base nas dimensões culturais de Hofstede, e verificar a relação entre os valores culturais e o comportamento de risco nas tomadas de decisão em cenários de ganho e de perda. Para isso, foi aplicado um questionário via e-mail e redes sociais, obtendo-se respostas de 448 participantes. Utilizou-se o método dos mínimos quadrados ordinários com inferência estatística via bootstrap. Das hipóteses testadas, constatou-se uma influência positiva entre a aversão à incerteza e o prêmio relativo ao risco no modelo de ganho. Ademais, houve resultados estatisticamente significativos entre variáveis de controle e o apetite pelo risco. O estudo contribui para o preenchimento da lacuna de pesquisa e para a ampliação do conhecimento na área, destacando a importância de conhecer as diferenças culturais entre as regiões brasileiras e os possíveis impactos no comportamento frente ao risco para empresas e formuladores de políticas públicas.

Abstract Introduction: Cardiovascular disease is an important cause of death among patients with chronic kidney disease (CKD). Valve calcification is a predictor of cardiovascular mortality and coronary artery disease. Objective: To assess heart valve disease frequency, associated factors, and progression in CKD patients. Methods: We conducted a retrospective study on 291 CKD patients at Hospital das Clínicas de Pernambuco. Inclusion criteria were age ≥ 18 with CKD and valve disease, while those on conservative management or with missing data were excluded. Clinical and laboratory variables were compared, and patients were categorized by dialysis duration (10 years). Statistical tests, including chi-square, Fisher’s exact, ANOVA, and Kruskal-Wallis, were employed as needed. Simple and multivariate binary regression models were used to analyze valve disease associations with dialysis duration. Significance was defined as p < 0.05. Results: Mitral valve disease was present in 82.5% (240) of patients, followed by aortic valve disease (65.6%; 86). Over time, 106 (36.4%) patients developed valve disease. No significant association was found between aortic, pulmonary, mitral, or tricuspid valve disease and dialysis duration. Secondary hyperparathyroidism was the sole statistically significant factor for mitral valve disease in the regression model (OR 2.59 [95% CI: 1.09–6.18]; p = 0.031). Conclusion: CKD patients on renal replacement therapy exhibit a high frequency of valve disease, particularly mitral and aortic valve disease. However, no link was established between dialysis duration and valve disease occurrence or progression.

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O Programa Farmácia Viva (FV) foi planejado com o objetivo de produzir fitoterápicos de qualidade com garantia de segurança e eficácia a partir de plantas medicinais validadas, buscando oferecer uma opção terapêutica, além de desenvolver trabalhos educativos sobre o uso correto de plantas medicinais. Este artigo tem por objetivo descrever a implantação de projeto piloto de FV na Unidade de Saúde da Família (USF) de Araraquara, com a finalidade de oferecer a fitoterapia como recurso terapêutico, promovendo o uso racional de plantas medicinais na Atenção Primária à Saúde (APS), resgatando o saber popular e baseado no conhecimento científico. Foi realizado um levantamento das principais doenças que acometem a população local e, a partir daí, foram selecionadas as plantas medicinais do projeto. Posteriormente iniciou-se o preparo do terreno para cultivo das mudas. Concomitantemente, foram realizadas rodas de conversa, cursos e oficinas com a comunidade e a equipe de saúde da USF sobre preparo de mudas e uso racional de plantas medicinais. Os resultados mostraram que ansiedade, problemas respiratórios, gástricos e inflamação são as patologias que mais acometem a população local. As seguintes espécies foram selecionadas para serem cultivadas: Curcuma longa (cúrcuma), Cymbopogon citratus (capim limão), Lippia alba (lípia), Maytenus ilicifolia (espinheira santa), Mikania glomerata (guaco) e Plectrantus barbatus (boldo nacional), seguindo o Formulário Fitoterápico da Farmacopeia Brasileira. As rodas de conversa, oficinas e cursos possibilitaram à comunidade e equipe de saúde local o acesso às informações científicas, em linguagem simples, valorizando trocas de experiências, descrevendo as plantas medicinais, suas propriedades terapêuticas, forma de preparo, dosagem e contraindicações. As oficinas de chá permitiram aos participantes resgatar a memória afetiva da família, fator importante para o sucesso do projeto FV. A FV é um projeto social que tem demonstrado resgatar a autoestima da comunidade e a capacidade de orientar o uso racional de plantas medicinais, valorizando a fitoterapia como recurso terapêutico de escolha no sistema de saúde.

Abstract Green spaces in urban areas—like remnant habitat, parks, constructed wetlands, and street trees—supply multiple benefits. Many studies show green spaces in and near urban areas play important roles harbouring biodiversity and promoting human well‐being. On the other hand, evidence suggests that greater human population density enables compact, low‐carbon cities that spare habitat conversion at the fringes of expanding urban areas, while also allowing more walkable and livable cities. How then can urban areas have abundant green spaces as well as density? In this paper, we review the empirical evidence for the relationships between urban density, nature, and sustainability. We also present a quantitative analysis of data on urban tree canopy cover and open space for United States large urbanized areas, as well as an analysis of non‐US Functional Urban Areas in OECD countries. We found that there is a negative correlation between population density and these green spaces. For Functional Urban Areas in the OECD, a 10% increase in density is associated with a 2.9% decline in tree cover. We argue that there are competing trade‐offs between the benefits of density for sustainability and the benefits of nature for human well‐being. Planners must decide an appropriate density by choosing where to be on this trade‐off curve, taking into account city‐specific urban planning goals and context. However, while the negative correlation between population density and tree cover is modest at the level of US urbanized areas (R2 = 0.22), it is weak at the US Census block level (R2 = 0.05), showing that there are significant brightspots, neighbourhoods that manage to have more tree canopy than would be expected based upon their level of density. We then describe techniques for how urban planners and designers can create more brightspots, identifying a typology of urban forms and listing green interventions appropriate for each form. We also analyse policies that enable these green interventions illustrating them with the case studies of Curitiba and Singapore. We conclude that while there are tensions between density and urban green spaces, an urban world that is both green and dense is possible, if society chooses to take advantage of the available green interventions and create it. Read the free Plain Language Summary for this article on the Journal blog.

ABSTRACT The natural durability of the wood is essential for the definition of its use, and this property can be enhanced with the proper chemical treatment of the wood. Thus, the objective of this study was to evaluate the resistance to termites and decay fungi of Jacaranda copaia wood chemically modified through acetylation. Five experimental treatments were assessed: acetylation for 2, 4, 6 and 8 hours and a control (non-acetylated). The acetylation was carried out by immersing wood samples in acetic anhydride at 90 °C. Acetylated and control samples were subjected to the action of xylophagous termites (Nasutitermes sp.) and decaying fungi (Gloeophyllum trabeum and Trametes versicolor). The acetylation process significantly increased the resistance of Jacaranda copaia wood to the attack of the xylophagous organisms. There was no mass loss after exposure to termites of the wood in any of the acetylation treatments, while in the control wood, mass loss was 9.5%. Regarding the decaying fungi, mass loss occurred in all treatments. Acetylation for 6 and 8 hours were the most efficient chemical treatments, increasing the resistance class of the Jacaranda copaia wood to highly resistant.

O Cuidado Farmacêutico está inserido na prática da Farmácia Clínica, sendo constituído por nove serviços farmacêuticos, destinados ao paciente, à família e à comunidade. O objetivo deste estudo foi avaliar o aprendizado dos participantes em um curso online sobre Cuidado Farmacêutico totalizando 30 horas contendo dez módulos baseados nos Serviços Clínicos Farmacêuticos, por meio de questionários de pré-teste e de pós-teste. O estudo é de natureza quantitativa, de caráter descritivo, transversal, exploratório e de investigação quase-experimental com pré- e pós-teste. Os dados dos 209 participantes foram coletados no curso de Cuidado Farmacêutico, sendo este caracterizado como curso livre, realizado de 16 de novembro a 5 de dezembro de 2020, via questionários com 18 questões idênticas. As análises foram realizadas nos softwares Minitab 18.0 e SPSS 20. Os dados das amostras independentes apresentaram maior média de pós-teste em comparação com o pré-teste, forte correlação linear positiva, inclinação da reta de regressão linear acentuada positivamente, demostrando que quanto maiores as variáveis explicativas (nível de escolaridade e nota de pré-teste), maior a nota como variável resposta do modelo, e, além disso, no DOE, considerando fatores sexo, conhecimento prévio e nível de escolaridade, apenas o conhecimento prévio foi signifi cativo para as medianas e variâncias, independentemente de nível de escolaridade e gênero, comprovando-se estatisticamente que o curso agregou conhecimento sobre o Cuidado Farmacêutico.

É apresentado um caso de tumor de Wilms bilateral em criança de um ano. O primeiro tumor, de rim direito, tinha o aspecto histopatológico clássico e apenas 10 % de sua área era representada por fibras musculares estriadas de tipo embrionário. O tumor do rim esquerdo manifestou-se quatro meses após o diagnóstico do primeiro e era constituído quase que exclusivamente por tecido muscular estriado embrionário. A criança está agora com 10 anos e vive normalmente com apenas dois terços de um rim.

Approximately 125 years ago, a group of pathologies now known as Chiari malformations was described for the first time. However, some mechanisms of its formation still remain unknown. A bibliographic survey was performed through a search in PubMed. In 1938, it was already theorized that an increase in spinal cord tension could be the cause of Chiari malformation type 1 (CM1) tonsillar herniation. In 1953, a condition known for the anchoring of the filum terminale to the vertebral canal was described for the first time and would later be known as tethered cord syndrome (TCS). Some studies have shown that it is associated with increased tension in the spinal cord, and this formed the basis for a possible pathophysiological explanation of tonsillar herniation. Case series emerged reporting that treatment for TCS with the sectioning of the filum terminale (SFT) could provide clinical improvement of patients with CM1. A new pathological entity emerged when it was realized that patients with the clinical picture of TCS could have the medullary cone in its normal position, differing from the caudal migration expected for the TCS. This condition became known as occult tethered cord syndrome (OTCS). Case series attempted to demonstrate its association with the origin of CM1, a non-intuitive association, since the cone in the normal position contradicts traction as a source of tonsillar herniation. To this day, the absence of randomized control trials limits any conclusions regarding the effectiveness of SFT for the treatment of patients with CM1.

The study aimed to evaluate the antitumor and toxicogenetic effects of liposomal nanoformulations containing citrinin in animal breast carcinoma induced by 7,12-dimethylbenzanthracene (DMBA). Mus musculus virgin females were divided into six groups treated with (1) olive oil (10 mL/kg); (2) 7,12-DMBA (6 mg/kg); (3) citrinin, CIT (2 mg/kg), (4) cyclophosphamide, CPA (25 mg/kg), (5) liposomal citrinin, LP-CIT (2 μg/kg), and (6) LP-CIT (6 µg/kg). Metabolic, behavioral, hematological, biochemical, histopathological, and toxicogenetic tests were performed. DMBA and cyclophosphamide induced behavioral changes, not observed for free and liposomal citrinin. No hematological or biochemical changes were observed for LP-CIT. However, free citrinin reduced monocytes and caused hepatotoxicity. During treatment, significant differences were observed regarding the weight of the right and left breasts treated with DMBA compared to negative controls. Treatment with CPA, CIT, and LP-CIT reduced the weight of both breasts, with better results for liposomal citrinin. Furthermore, CPA, CIT, and LP-CIT presented genotoxic effects for tumor, blood, bone marrow, and liver cells, although less DNA damage was observed for LP-CIT compared to CIT and CPA. Healthy cell damage induced by LP-CIT was repaired during treatment, unlike CPA, which caused clastogenic effects. Thus, LP-CIT showed advantages for its use as a model of nanosystems for antitumor studies.

Background: This study aimed to determine the prevalence, beliefs, attitudes, and perceptions of hookah use in a population of undergraduate students at a large public university in Brazil. Methods: The sample consisted of 1348 undergraduate students aged over 18-year-old. They completed structured questionnaires on demographic information and close-ended questions on the past and current experiences of smoking hookah. The data underwent descriptive analysis and binary logistic regression.Findings: Finally, 1298 valid survey forms were obtained from printed and digital questionnaires. More than half (53.9%) of participants reported having tried hookah at least once, however, only 10.8% reported they had experienced it within the last 30 days. The majority of the studied population presented acceptable beliefs about the harmfulness and addictive capacity of hookah smoking. However, when comparing the perceptions of those who had smoked and those who had never smoked hookah, and also, the perceptions of users and non-users, significant differences were observed. Students who were users or had already tried hookah showed a tendency to underestimate the deleterious effects of this type of smoking.Conclusion: It could be concluded that hookah smoking was common among Brazilian university students. In addition, preoccupying misperceptions of hookah’s harmfulness and addictive capacity were found. The results showed that the epidemic of hookah smoking, especially among young people, has spread far beyond the Arab world and the Persians. Accordingly, preventive measures must be taken if this population is to be protected from addiction and other serious health problems.

Abstract This study evaluated the effect of photobiomodulation therapy (PBMT) with a red or infrared laser on the repair of post extraction sockets in rats administered alendronate (ALN). Forty male rats were randomly allocated into four groups: Control Group (CTR): subcutaneous administration of saline solution throughout the experimental period; Alendronate Group (ALN): subcutaneous administration of alendronate during the entire experimental period; Alendronate/Red Laser Group (ALN/RL): administration of ALN and irradiation with a GaAlAs laser (λ 660 nm); and Alendronate/Infrared Laser Group (ALN/IRL): administration of ALN and irradiation with a GaAlAs laser (λ 830 nm). The first lower molars were extracted 60 days after the beginning of the administration of the drugs. The PBMT was applied after tooth extraction (7 sessions with intervals of 48 hours between sessions). Thirty days after tooth extraction, the animals were euthanized. Micro-CT and histometric analysis were performed to assess the bone healing and soft tissue repair of the tooth socket. The ALN group presented with more bone than the CTR; however, most of this bone was necrotic. ALN does not affect the bone microarchitecture. On the other hand, PBMT with IRL enhances the bone density due to the increase in the number and reduction in the spacing of the trabeculae. The amount of vital bone and connective tissue matrix was higher in the ALN/RL and ALN/IRL groups than in the ALN and CTR groups. PBMT enhanced the healing of the post extraction sockets in rats subjected to ALN administration. Furthermore, IRL improved the new bone microarchitecture.

Resumo Fundamento A mensuração indireta da pressão sanguínea (PS) é sabidamente influenciada por diversos fatores como técnica, observador e equipamento, mas a influência da composição do braço ainda não foi investigada. Objetivo Identificar a influência da gordura do braço sobre a medida indireta da pressão sanguínea, utilizando modelos de inferência estatística e machine learning. Métodos Estudo transversal, com 489 adultos jovens saudáveis de 18 a 29 anos de idade. Foram medidos comprimento (COB), circunferência do braço (CB) e índice de gordura do braço (IGB). A PS foi mensurada em ambos os braços, simultaneamente. Os dados foram processados utilizando-se Python 3.0 e pacotes específicos para análise descritiva, regressão e clusterização. Um nível de significância de 5% foi adotado para todos os cálculos. Resultados A PS e as medidas antropométricas foram diferentes entre os hemicorpos. A pressão sanguínea sistólica (PAS), COB, e IGB foram maiores no braço direito (BD), enquanto CB foi similar em comparação ao braço esquerdo. COB e CB apresentaram correlação positiva com a PAS. Conforme o modelo de regressão, para determinado valor de CB e COB, a leitura da PAS poderá ter uma redução média de 1,80 mmHg no BD, e 1,62 mmHg no braço esquerdo, a cada 10% de aumento na IGB. A clusterização corroborou os resultados da regressão. Conclusão Foi encontrada uma influência significativa do IGB sobre a leitura da PS. A PAS teve correlação positiva com COB e CB, e correlação negativa com IGB, o que sugere a necessidade de mais investigações sobre a relação da PS com as frações de gordura e músculo do braço.

Este artigo apresenta resultados da aplicação da oficina “Desenhando a paisagem nossa de cada dia”, através da representação da paisagem por meio da arte, através de desenhos, para alunos do Ensino Fundamental - Anos finais do município de Meruoca, Ceará. Objetivamos demonstrar a capacidade lúdica que a ferramenta artística pode promover na assimilação da realidade vivida no ambiente Semiárido, mediante representação da paisagem. Adotamos a inserção de oficinas de desenho utilizando a Fenomenologia como referencial teórico-metodológico. É válido enfatizar que a questão da aplicabilidade de tais alternativas na prática do ensino em Geografia, sobretudo, em aspectos físico-naturais, pode ocasionar um envolvimento dos participantes, sob a influência de uma perspectiva lúdica, visando uma estratégia mais interativa.

The present work, based on the Theory of the Imaginary, tries to find the imagery itinerary of José Luís Peixoto in the Return home, starting from the discussions about the myth of return - resonated since the Odyssey - and the Poetics of space, by Bachelard (2008), since these two images (return/home) are intertwined throughout the poetic narrative, which Added to these two founding elements of the text, it is observed how time in the closed space of the house unlocked, in the subject, feelings of fear and uncertainty in the face of the present. In this sense, it was found that the image of the house, in the aforementioned book, still recovers the symbolic of a protective space, updated in the experience of social isolation. The same update movement happens in the recovery of the Homeric myth, from which one can think of how the subjects found the need to return to the family environment because of the pandemic, at the same time that the For the realization of this article, we resort to the theoretical-methodological postulates of Bachelard (2008), Durand (1993), Mello (2002) and other authors.

Peripheral nerve injuries vary in length and severity, and they can occur secondary to trauma, compression and ischemia, leading to both motor and sensory neurological deficits. Nerve compression can occur in both the upper and lower limbs. These injuries can affect the quality of life, including the total or partial loss of the individual's productive capacity. The diagnostic methods are based on clinical criteria, but they may also include imaging and electroneurophysiological studies. A clinical examination using the Tinel and Phalen tests, for example, may suggest carpal tunnel syndrome. Complementary exams are used to confirm the diagnosis and rule out other possibilities, and the most used are electroneuromyography (ENMG), computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography (US). Depending on the type of injury, recovery may be spontaneous or may require conservative or surgical treatment.

ABSTRACT We aimed to investigate the relationship between workforce [força de trabalho (FT)] and earnings management in the Brazilian capital market and, additionally, identify whether operating activities management is a substitute for management by accruals. Evidence of the effect of the FT on earnings management practice is controversial, sometimes showing an effect on the reduction or smoothing of profit or even no effect. In Brazil, there are no studies that investigate how the intensity of the FT affects the managers’ behavior regarding the manipulation of profit. The research is relevant to the regulatory bodies because it brings empirical evidence of the incentives generated by the pressure of the FT so that the top executives reduce the result of the period, in a substitute way, to the manipulation of the company's operational activities. In addition, it is relevant for users of accounting information, as it demonstrates that the FT influences the recognition of results, affecting the quality of accounting information. The findings may assist regulatory bodies and investors, as it demonstrates that pressure from the FT is an important incentive for decision-making by executives and workers at the operating levels of companies and can support the improvement of labor regulations. Following Pae (2005), we use Jones' modified model (1991) with lagged accruals to detect earnings management. To capture the FT intensity, we employed the proxies presented by Hilary (2006) and a variable calculated from the statement of value added [demonstração do valor adicionado (DVA)]. We analyzed 119 companies listed on the Brazilian stock exchange during the period 2012-2018. It were found that the intensity of the FT negatively influences earnings management by accruals [gerenciamento de resultados por accruals (GRA)], expanding the evidence on the effects of workers' bargaining power on accounting choices.

A fractile is a location on a probability density function with the associated surface being a proportion of such a density function. The present study introduces a novel methodological approach to modeling data within the continuous unit interval using fractile or quantile regression. This approach has a unique advantage as it allows for a direct interpretation of the response variable in relation to the explanatory variables. The new approach provides robustness against outliers and permits heteroscedasticity to be modeled, making it a tool for analyzing datasets with diverse characteristics. Importantly, our approach does not require assumptions about the distribution of the response variable, offering increased flexibility and applicability across a variety of scenarios. Furthermore, the approach addresses and mitigates criticisms and limitations inherent to existing methodologies, thereby giving an improved framework for data modeling in the unit interval. We validate the effectiveness of the introduced approach with two empirical applications, which highlight its practical utility and superior performance in real-world data settings.

This study presented a rehabilitation option for malpositioned implants; this involved obtaining their position and inclination through intraoral scanning, and producing a customized abutment with CAD/CAM technology. The patient in this case report presented a root fracture in tooth 21 and was subjected to extraction, implant installation, and immediate provisional prosthesis. The implant was installed with a distal inclination due to anatomical limitations. After osseointegration, an intraoral scanning transfer provided a digital model (file extension .stl), which reproduced the implant’s position and inclination. Then, the file was sent so that a customized abutment (CAD/CAM) could be manufactured, promoting the final rehabilitation of the case; this allowed for good hygiene, load distribution in the dynamic interocclusal relationship, and favorable esthetics, whereas many would otherwise recommend implant removal. The result presented lower costs, a shorter time frame, and a lower morbidity for the patient.