86 results on '"Jorquera-Plaza F"'
Search Results
2. RESULTS OF A COLORECTAL SCREENING PROGRAMME BELOW THE FIT THRESHOLD OF 100 NG/ML (20UG/G)
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Matias, DJ, additional, Rodríguez Martín, L, additional, Villar Lucas, C, additional, Quiñones Castro, R, additional, Pérez Fernández, R, additional, Diez Rodríguez, R, additional, Jiménez Palacios, M, additional, Jorquera Plaza, F, additional, and Vivas Alegre, S, additional
- Published
- 2019
- Full Text
- View/download PDF
3. DIEULAFOY'S LESION: CLINICAL AND EPIDEMIOLOGICAL ANALYSIS OF AN UNCOMMON CAUSE OF GASTROINTESTINAL HEMORRHAGE
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João Matias, D, additional, Monteserin Ron, L, additional, Vaquero Ayala, L, additional, Fernández Fernández, N, additional, Vivas Alegre, S, additional, Rodríguez Martín, L, additional, and Jorquera Plaza, F, additional
- Published
- 2018
- Full Text
- View/download PDF
4. UTILITY OF FAECAL OCCULT BLOOD TEST (FOBT) OUT OF COLORECTAL CANCER SCREENING PROGRAMME
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Rodríguez Martín, L, additional, Matias, DJ, additional, Monteserín Ron, L, additional, Vivas Alegre, S, additional, Díez Rodríguez, R, additional, Villar Lucas, C, additional, Quiñones Castro, R, additional, Fernández, MI, additional, Fernández Morán, E, additional, and Jorquera Plaza, F, additional
- Published
- 2018
- Full Text
- View/download PDF
5. ENDOSCOPIC FINDINGS IN AN INICIAL ROUND OF COLORECTAL CANCER SCREENING IN A POPULATION FROM 60 TO 70 YEARS OLD
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Matias, DJ, additional, Monteserín Ron, L, additional, Rodríguez Martín, L, additional, Vivas Alegre, S, additional, Díez Rodríguez, R, additional, Reyes Campos, N, additional, Molina Arriero, G, additional, Fernández, MI, additional, Fernández Morán, E, additional, and Jorquera Plaza, F, additional
- Published
- 2018
- Full Text
- View/download PDF
6. Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León
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Muela Molinero, A., Jorquera Plaza, F., Ribas Ariño, T., Malagón Rojo, R., Espinel Díez, V., Ballesteros del Río, B., Olcoz Goñi, J. L., and Santos Calderón, J. A.
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Sincrónicas ,Supervivencia ,Survival ,Prostate ,Pronóstico ,Neoplasias múltiples ,Metachronous ,Multiple neoplasms ,Prognosis ,Próstata ,Synchronous ,Oncología ,Metacrónicas ,Oncology - Abstract
Objectives: we analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN) in the Health District of León. Material and methods: using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed. Results: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26%) and urologic (21%); 87% of patients were diagnosed with a second neoplasm within the first two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN. Conclusions: MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN. Secondary prevention is the best measure to avoid MMPN development. Objetivos: analizar las características de los pacientes con tumores gástricos diagnosticados de una neoplasia primaria maligna múltiple (NPMM) en el área sanitaria de León. Pacientes y método: utilizando los datos del Registro de Tumores del Hospital de León se han seleccionado aquellos pacientes con tumores gástricos diagnosticados entre 1993 y 2002. Se realizó un seguimiento hasta el 31 de diciembre de 2004 analizando las características de los pacientes diagnosticados de una segunda neoplasia durante el periodo de seguimiento. Resultados: la prevalencia de NPMM fue del 1,96%. El 56% de los pacientes tenían antecedentes oncológicos en familiares de primer grado. Las segundas neoplasias más frecuentes fueron las digestivas (26%) y las urológicas (21%). El 87% de los pacientes fueron diagnosticados del segundo tumor en los primeros dos años. No se observaron diferencias respecto a la supervivencia entre los pacientes con NPMM sincrónicas y metacrónicas. Conclusiones: las NPMM en los pacientes con cáncer gástrico son un problema relevante. Aunque los agentes carcinógenos externos puedan actuar como promotores en el desarrollo de una segunda neoplasia, en estos pacientes parece existir una base genética que favorece el desarrollo del una NPMM. La prevención secundaria es la mejor medida para evitar el desarrollo de una NPMM.
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- 2006
7. Multicentric colo-rectal cancer (MSCC) in the health district of León
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Muela Molinero, A., Jorquera Plaza, F., Ribas Ariño, T., Malagón Rojo, R., Morán Blanco, A., Martínez Nuñez, A. L., Guerra Laso, J., and Santos Calderón, J. A.
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Sincrónicas ,Supervivencia ,Survival ,Colon ,Rectum ,Neoplasias múltiples ,Metachronous ,Cáncer ,Multiple neoplasms ,Prognosis ,digestive system diseases ,Oncología ,Synchronous ,Metacrónicas ,Colon. Recto ,Oncology ,Cancer - Abstract
OBJETIVOS: Analizar las características de los pacientes diagnosticados de CCRM en el área sanitaria de León, el impacto sobre la supervivencia y las posibles variables pronósticas. MATERIAL Y MÉTODOS: Utilizando los datos del Registro de Tumores del Hospital de León se han analizado las características de aquellos pacientes con tumores colo-rectales diagnosticados entre 1993 y 2002, clasificándolos dos grupos: el primero constituido por 74 pacientes diagnosticados de CCRM y el segundo formado por 1342 pacientes con tumores únicos diagnosticados en el bienio 1996-1997. RESULTADOS: La frecuencia de CCRM fue del 2,7%. La edad de los pacientes con CCRM fue 2 años mayor con respecto a la de los pacientes con neoplasias únicas, con una elevada proporción (38%) de antecedentes familiares oncológicos en familiares de primer grado. No se observaron diferencias significativas en cuanto a la localización y el estadio del primer tumor colo-rectal con respecto al grupo de tumores únicos. La supervivencia de los pacientes con CCRM metacrónico fue netamente inferior, posiblemente en relación con un mayor número de segundas neoplasias diagnosticadas en estadios tempranos en los pacientes con CCRM sincrónico. Las variables que influyeron en el pronóstico fueron la edad, el sexo, y el padecimiento de un CCRM sincrónico o metacrónico. CONCLUSIONES: El CCRM es una entidad frecuente en nuestro medio. La tasa de antecedentes familiares oncológicos en estos pacientes es muy elevada. No se encontraron diferencias significativas en cuanto al pronóstico de estos pacientes respecto al de los pacientes con neoplasias únicas. PURPOSE: We analyze the characteristics of patients with multicentric colo-rectal cancer (MCRC) in the health district of León, the impact on survival, and the prognostic variables. MATERIAL AND METHODS: : Using the data from the Hospital de León Tumour Registry, we analyzed the characteristics of all the patients diagnosed of having colo-rectal tumours between 1993 and 2002. The patients were classified in two groups: one of them composed by 74 patients with MCRC, and the other formed by 1342 patients diagnosed in 1996 and 1997 of having single colo-rectal tumours. RESULTS: The observed frequency of MCRC corresponded to 2.7 percent of the whole cases. The age of the MCRC patients was 2 years higher than that of the patients with single neoplasms, and showed a higher familial oncologic history, that was present in 38 percent of the cases. No differences were observed for location and stage of the first appeared colo-rectal neoplasm. The survival of the patients developing metachronous MCRC was lower than for those with synchronous disease, possibly due to the higher number of the second neoplasms appearing in these patients at early stages. Prognostic values were age, sex, and metachronous or synchronous type of disease. CONCLUSIONS: MCRC is a frequent entity. The frequency of familial oncologic history is very high. No significant differences were seen in relation to prognosis between single and multiple colo-rectal cancer.
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- 2006
8. Prótesis enterales en el tratamiento paliativo de la obstrucción gastroduodenal: técnica endoscópica
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Espinel Díez, J., Jorquera Plaza, F., Domínguez Carbajo, A., López Cuesta, D., Suárez Álvarez, P., Bailador Andrés, C., Álvarez Posadilla, M., and Olcoz Goñi, J. L.
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Procedimientos endoscópicos ,Gastric emptyming ,Enteral prostheses ,Prótesis enterales ,Vaciamiento gástrico ,Endoscopic procedure - Abstract
La obstrucción gastroduodenal neoplásica puede causar una significativa morbilidad. La inserción de prótesis enterales como tratamiento paliativo es una aceptable opción para conseguir un adecuado vaciamiento gástrico sin la morbilidad asociada a la cirugía paliativa, con menor mortalidad relacionada con el procedimiento y menor coste, proporcionando una mejor calidad de vida. Es importante unificar y consolidar la técnica endoscópica de colocación de las prótesis enterales evitando variaciones que impidan un adecuado análisis de los resultados de esta técnica. Malignant gastroduodenal obstruction may cause significant morbidity. Insertion of enteral prostheses as a palliative treatment is an acceptable option to achieve an appropriate gastric voiding without the morbidity associated to palliative surgery, with a lesser procedure-related mortality and a lower cost, while providing a better quality of life. Its is important to unify and consolidate the endoscopic procedure for the placement of enteral prostheses, avoiding variations that may preclude an adequate analysis of this procedure outcome.
- Published
- 2005
9. Neoplasias malignas múltiples en pacientes con cáncer de próstata en el área sanitaria de León
- Author
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Muela Molinero, A., Jorquera Plaza, F., Malagón Rojo, R., Ribas Ariño, M. T., and Muñoz Rodríguez, M.
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Sincrónicas ,Supervivencia ,Survival ,Pronóstico ,Prostate ,Neoplasias múltiples ,Metachronous ,Próstata ,Multiple neoplasms ,Prognosis ,Oncología ,Synchronous ,Metacrónicas ,Elderly ,Oncology - Abstract
Objetivos: Analizar las características de los pacientes con tumores prostáticos que desarrollaron una neoplasia primaria maligna múltiple (NPMM) en el área sanitaria de León, el impacto sobre la supervivencia y las posibles variables pronósticas. Material y métodos: Utilizando los datos del Registro de Tumores del Hospital de León se han seleccionado aquellos pacientes con tumores prostáticos diagnosticados entre 1993 y 2002, creando dos grupos: el primero constituido por 67 pacientes con NPMM y el segundo formado por 145 pacientes con tumores únicos diagnosticados entre 1996 y 1997. Resultados: La prevalencia de NPMM fue del 5,57%. Los pacientes con NPMM fueron 3 años más jóvenes que los pacientes con tumores únicos, con una elevada proporción (41%) de antecedentes familiares oncológicos en familiares de primer grado. La asociación más frecuente fue el cáncer urológico sincrónico. El 86% de los pacientes fueron diagnosticados del segundo tumor en los primeros dos años. La supervivencia de los pacientes con NPMM metacrónicas fue inferior a la de los pacientes con NPMM sincrónicas, siendo las variables con significación pronóstica la edad, el padecimiento de una NPMM metacrónica, el estadio del segundo tumor y el padecimiento de un segundo tumor urológico. Conclusiones: Las NPMM en pacientes con tumores prostáticos son relativamente frecuentes en nuestro medio. Parece existir una base genética en estos pacientes. El pronóstico de los pacientes con NPMM metacrónicas es peor. No existen diferencias significativas en cuanto al pronóstico con respecto a los pacientes con tumores únicos. Objetive: We analize the characteristics of the patients with prostate tumours who developed a multiple malignant primary neoplasms (MMPN) in the health district of León, the impact on survival and the prognostic variables. Material and methods: We have used the data from the Tumour Registry of the Hospital of León and we have selected all those patients who were diagnosed of a prostate tumor between 1993 and 2002. Later we made two groups: the first with 67 patients with MMPN and a second group with 145 patients with single prostate tumours diagnosed during 1996 and 1997. Results: Prevalence of MMPM was of 5.57 percent. Patients with MMPN were 3 years younger thant those with single tumours, with a high frecuency (41 percent) of familial oncologic antecedents on first degree parents. The more frequent association was the synchronous urologic neoplasm. During the next two years from diagnosed of prostate tumour, 86 percent of patients with MMPN were diagnosed of their second neoplasm. Survival of metachronous MMPN patients was lower than synchronous MMPN patients, being the variables with prognosis significance the age, metachronous MMPN, stage of second neoplasms and if the second neoplasms was or not urologic. Conclusions: MMPN in patients with prostatic tumours are frequent in our medium. A genetic base may be associated in these patients. Prognosis of metachronous MMPN patients is worse. No differences were observed about prognosis with single tumour patients.
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- 2005
10. Prótesis enterales en el tratamiento paliativo de la obstrucción gastroduodenal: técnica endoscópica
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Espinel Díez,J., Jorquera Plaza,F., Domínguez Carbajo,A., López Cuesta,D., Suárez Álvarez,P., Bailador Andrés,C., Álvarez Posadilla,M., and Olcoz Goñi,J. L.
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Procedimientos endoscópicos ,Prótesis enterales ,Vaciamiento gástrico - Abstract
La obstrucción gastroduodenal neoplásica puede causar una significativa morbilidad. La inserción de prótesis enterales como tratamiento paliativo es una aceptable opción para conseguir un adecuado vaciamiento gástrico sin la morbilidad asociada a la cirugía paliativa, con menor mortalidad relacionada con el procedimiento y menor coste, proporcionando una mejor calidad de vida. Es importante unificar y consolidar la técnica endoscópica de colocación de las prótesis enterales evitando variaciones que impidan un adecuado análisis de los resultados de esta técnica.
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- 2005
11. Las lesiones anátomo-patológicas de la hepatitis crónica C como factores predictivos de respuesta mantenida al tratamiento con interferón
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Gento Peña, E., López Morante, A., Cordero Guevara, J., Echevarría Iturbe, C., Martín Lorente, J. L., Olcoz Goñi, J. L., González San Martín, F., Caro-Patón Gómez, A., Jorquera Plaza, F., Velicia Llames, R., and Sáez-Royuela, F.
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Hepatitis C virus ,Interferon ,Histopathology ,Interferón ,Anatomía patológica ,Chronic hepatitis C ,Virus de la hepatitis C ,Hepatitis crónica C - Abstract
Introducción: Aunque se han realizado múltiples estudios para conocer los factores pre-tratamiento que pueden predecir la respuesta al tratamiento con interferón (IFN), se desconoce si las lesiones histológicas características de la hepatitis crónica C (HCC) sirven para predecir dicha respuesta. Objetivos: Valorar si los parámetros histológicos pueden predecir la respuesta mantenida al tratamiento con IFN en los pacientes con HCC, y estudiar otros parámetros (epidemiológicos y analíticos) ya descritos como factores predictivos de respuesta. Métodos: Se estudiaron de forma retrospectiva 201 pacientes, tratados con IFN durante al menos 3 meses en cuatro hospitales de Castilla y León. La variable dependiente analizada fue la respuesta mantenida al tratamiento. Como factores predictivos de respuesta se estudiaron las siguientes variables histológicas: diagnóstico histológico, índice de Knodell total y por apartados, grado y estadio, y lesiones características de la HCC. Además, se analizaron parámetros epidemiológicos y analíticos. Resultados: El 16% de los pacientes presentó una respuesta mantenida. Ninguno de los parámetros histológicos sirvió para predecir dicha respuesta. Demostraron ser factores predictivos en el análisis bivariante la edad, el tiempo de evolución de la HCC, la vía de transmisión, la GGT, la ferritina y el genotipo viral. El factor predictivo más importante fue el genotipo viral, y el único asociado independientemente a la respuesta mantenida ("odds ratio" de respuesta al tratamiento de 8,6). Conclusiones: Los parámetros histológicos no predicen la respuesta al tratamiento con IFN. Otros factores, fundamentalmente el genotipo viral, se asocian a un mayor porcentaje de respuestas, aunque ninguno sirve para decidir con exactitud qué pacientes responderán. Background: Although many studies have been implemented in order to determine the pre-treatment factors that can predict patients' response to interferon (IFN) therapy, it is not yet clear whether characteristic histologic abnormalities in chronic hepatitis C can predict such response. Aims: The aims of this study were to evaluate, in patients with chronic hepatitis C, (i) the predictive value of histologic lesions for the sustained response to IFN therapy (ii) other pre-treatment (epidemiological and analytical) factors known to be predictive of response. Patients and methods: Sustained response was retrospectively evaluated in two hundred one patients who had been treated with IFN for at least 3 months in four different hospitals from Castilla y León. The following histological parameters were studied as predictors of response: histological diagnosis, Knodell index, grading and stage, characteristic histologic lesions of HCV infection. Epidemiological and analitycal parameters were also evaluated. Results: The rate of patient's sustained response to IFN treatment was 16%. None of the histological parameters was useful to predict this response. By univariate analysis, age, disease evolution time, mode of viral transmission, GGT, ferritin and viral genotype were associated with a sustained response. The most powerful, and only independent predictive factor, however, was the genotype (the response odds ratio was 8.6). Conclusions: Histological parameters do not predict the response to IFN treatment. Other factors (mainly the viral genotype) are associated with a higher response percentage, although no one is useful to decide which patients are going to respond.
- Published
- 2001
12. Realidades en el abordaje enteral para la nutrición de nuestros pacientes
- Author
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Jorquera Plaza, F., primary, Espinel Díez, J., additional, and Olcoz Goñi, J.L., additional
- Published
- 2006
- Full Text
- View/download PDF
13. Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León
- Author
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Muela Molinero, A., primary, Jorquera Plaza, F., additional, Ribas Ariño, T., additional, Malagón Rojo, R., additional, Espinel Díez, V., additional, Ballesteros del Río, B., additional, Olcoz Goñi, J. L., additional, and Santos Calderón, J. A., additional
- Published
- 2006
- Full Text
- View/download PDF
14. Cáncer colo-rectal multicéntrico (CCRM) en el área sanitaria de León
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Muela Molinero, A., primary, Jorquera Plaza, F., additional, Ribas Ariño, T., additional, Malagón Rojo, R., additional, Morán Blanco, A., additional, Martínez Nuñez, A. L., additional, Guerra Laso, J., additional, and Santos Calderón, J. A., additional
- Published
- 2006
- Full Text
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15. Esfinterotomía de aguja como técnica de acceso a la vía biliar: estudio prospectivo
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Espinel Diez, J., primary, Vivas Alegre, S., additional, Muñoz Núñez, F., additional, Domínguez Carbajo, A., additional, Villanueva Pavón, R., additional, Jorquera Plaza, F., additional, and Olcoz Goñi, J.L., additional
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- 2005
- Full Text
- View/download PDF
16. Neoplasias malignas múltiples en pacientes con cáncer de próstata en el área sanitaria de León
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Muela Molinero, A., primary, Jorquera Plaza, F., additional, Malagón Rojo, R., additional, Ribas Ariño, M. T., additional, and Muñoz Rodríguez, M., additional
- Published
- 2005
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17. Leiomiosarcoma hepático primario en un paciente con linfoma no hodgkiniano gástrico
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Linares Torres, P., primary, Vivas Alegre, S., additional, Domínguez Carbajo, A.B., additional, Honrado Franco, E., additional, Espinel Díez, J., additional, Jorquera Plaza, F., additional, Olcoz Goñi, J.L., additional, and Castañón López, C., additional
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- 2002
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18. Hepatitis por danazol en paciente con déficit funcional de C1 inhibidor
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Estrada Rodríguez, J. L., primary, Jorquera Plaza, F., additional, Gozalo Reques, F., additional, and Álvarez Puebla, M. J., additional
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- 2001
- Full Text
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19. Las lesiones anátomo-patológicas de la hepatitis crónica C como factores predictivos de respuesta mantenida al tratamiento con interferón
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Gento Peña, E., primary, López Morante, A., additional, Cordero Guevara, J., additional, Echevarría Iturbe, C., additional, Martín Lorente, J. L., additional, Olcoz Goñi, J. L., additional, González San Martín, F., additional, Caro-Patón Gómez, A., additional, Jorquera Plaza, F., additional, Velicia Llames, R., additional, and Sáez-Royuela, F., additional
- Published
- 2001
- Full Text
- View/download PDF
20. Grado de asociación entre valores séricos y genotipo en el déficit de alfa-1-antitripsina. Utilidad clínica
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Martín Liras, S., primary, Díaz-Golpe, V., additional, Rivera Sevane, F., additional, González Cocaño, M.C., additional, Olcoz Goñi, J.L., additional, Linares Torres, P., additional, and Jorquera Plaza, F., additional
- Published
- 2001
- Full Text
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21. Estado actual de la CPRE. ¿Cómo se refleja la introducción de la colangiorresonancia magnética?
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Rueda Castañón, R., primary, Gutiérrez Arias, M., additional, Jorquera Plaza, F., additional, Linares Torres, P., additional, Vivas Alegre, S., additional, Espinel Díez, J., additional, Muñoz Núñez, F., additional, Domínguez Carbajo, A.B., additional, Rodríguez Morejón, C., additional, Herrera Abian, A., additional, Fernández Gundín, M.J., additional, Villanueva Pavón, R., additional, and Olcoz Goñi, J.L., additional
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- 2001
- Full Text
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22. Multicentric colo-rectal cancer (MSCC)in the health district of Le B>,Cáncer colo-rectal multicéntrico (CCRM) en el área sanitaria de León
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Muela Molinero, A., Jorquera Plaza, F., Ribas Ariño, T., Malagón Rojo, R., Alberto Morán Blanco, Martínez Nuñez, A. L., Guerra Laso, J., and Santos Calderón, J. A.
23. Hepatic metabolism of cholesterol
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García Mediavilla V, José Enrique BAYÓN-DARKISTADE, Jm, Culebras Fernández, Jorquera Plaza F, and García Díez F
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Bile Acids and Salts ,Cholesterol ,Liver ,Bile ,Homeostasis ,Humans - Abstract
Cholesterol is an essential component of all tissues, as it is a part of the structure of cell membranes, and it is an immediate precursor of a series of essential substances such as vitamins, steroid hormones, and bile acids. Under physiologic conditions, the intake and output of cholesterol in the organism is coordinated and balanced with the aim of guaranteeing the availability of adequate amounts of cholesterol to satisfy the needs of the different tissues (fig. 1). Under pathological conditions there is an imbalance between these mechanism, which leads to an increase in the circulating levels of cholesterol, leading to pathological processes such as hyperlipemias, atherosclerosis and bile stones. The liver plays a central role in the regulation of the homeostasis of cholesterol. The molecule enters the liver in the form of chylomicrons and low density lipoproteins (LDL), through lipoprotein receptors, and this is also the most important organ for the de novo biosynthesis of cholesterol from acetyl coenzyme A, by means of a cascade enzyme reaction in which the enzyme 3-hydroxy-3 methyl glutaryl CoA reductase (HMG-CoA) is the key of the entire process. Cholesterol is found in the liver in the form of cholesterol esters or as free cholesterol. The two most effective ways of eliminating body cholesterol are found in the liver, with the degradation of the compound to bile acids and the biliary secretion of cholesterol. The conversion to bile acids takes place through a series of enzymatic steps in which the formation of 7-alpha-hydroxycholesterol by the enzyme cholesterol 7-alpha-hydroxylase is the key of the process. The biliary secretion of cholesterol is 600 mg/day. Both the abundance and the universality of cholesterol in living things as its clinical implications emphasize the importance and interest of this compound.
24. Spontaneous bacterial peritonitis caused by Listeria monocytogenes
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Jorquera Plaza F, Espinel Díez J, Mj, Fernández Gundín, Muñoz Núñez F, Herrera Abián A, SANTIAGO VIVAS, and Jl, Olcoz Goñi
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Male ,Liver Cirrhosis, Alcoholic ,Spain ,Tobramycin ,Humans ,Ampicillin ,Listeriosis ,Peritonitis ,Aged - Abstract
We present a 68 year old male with alcoholic cirrhosis that was admitted with abdominal pain and fever. Hepatocarcinoma and spontaneous bacterial peritonitis by Listeria monocytogenes was diagnosed. The patient was treated with ampicillin and tobramycin during 25 days following a favorable course although ascitic fluid remained abnormal during 21 days. It is noted the rarity of Listeria as a cause of bacterial peritonitis in cirrhotic patients although they are immunodeficient. It is also important to establish the etiological origin because standard treatment of spontaneous bacterial peritonitis is cefotaxime and Listeria is resistant to this antibiotic. The 66% of spontaneous bacterial peritonitis secondary to Listeria monocytogenes infection in cirrhotic patients has been reported in Spain and this might be due to a higher incidence of human listeriosis in this country.
25. Multiple hepatic focal nodular hyperplasia: its presentation in childhood and atypical evolution
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SANTIAGO VIVAS, Jorquera Plaza F, Muñoz Núñez F, Herrera Abián A, Espinel Díez J, Mj, Fernández Gundín, Tascón Pérez R, and Jl, Olcoz Goñi
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Adult ,Hepatic Artery ,Liver ,Focal Nodular Hyperplasia ,Biopsy ,Chronic Disease ,Humans ,Female ,Tomography, X-Ray Computed ,Magnetic Resonance Imaging - Abstract
Multiple focal nodular hyperplasia is an uncommon benign liver tumor although its incidence has been increasing in the last few years. A case of focal nodular hyperplasia in a young woman is described, which was discovered in infancy and which presented two nodules in each lobe. The diagnosis was subsequently confirmed by large surgical biopsy. Conservative therapy was given for 16 years during which time there was progressive tumor growth, increase of pain and cholestatic enzymes. The unusual presentation this benign lesion may have, a strategy for its diagnosis and the generally conservative management that is currently favored are discussed.
26. [Spontaneous rupture of a pseudoaneurysm of the pancreaticoduodenal artery]
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Linares Torres, P., SANTIAGO VIVAS, Dominguez Carbajo, A. B., Fernandez Gundin, M. J., Munoz Nunez, F., Herrera Abian, A., Jorquera Plaza, F., and Olcoz Goni, J. L.
27. Neumomediastino espontáneo asociado a gastroenteritis aguda
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Jorquera Plaza, F., primary, Martínez Ramos, C., additional, and Carro Fernández, A., additional
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- 1989
- Full Text
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28. Benign intestinal pneumatosis associated with congenital Morgagni-Larrey diaphragmatic hernia.
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Blázquez Ávila V, Domínguez Carbajo AB, González Puente I, Martín Izquierdo A, Borrego Rivas S, and Jorquera Plaza F
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- Humans, Female, Aged, 80 and over, Tomography, X-Ray Computed, Hernias, Diaphragmatic, Congenital complications, Hernias, Diaphragmatic, Congenital diagnostic imaging, Pneumatosis Cystoides Intestinalis diagnostic imaging, Pneumatosis Cystoides Intestinalis complications
- Abstract
Intestinal pneumatosis (IN) is an uncommon radiological finding defined as the accumulation of air in the gastrointestinal tract wall. Its clinical signs are nonspecific and include symptoms such as diarrhea or abdominal pain. It includes benign entities (with subtle symptoms and the accumulation of air in the form of cysts that appear as clustered nodular lesions on the endoscopy, collapsible and soft); or severe cases (symptoms indicative of general health compromise and linear accumulation of air or free fluid suggestive of hollow viscus perforation); which require different management. We present the case of a patient diagnosed with benign intestinal pneumatosis (BIN), associated with anatomical changes due to a diaphragmatic hernia. CASE REPORT We report the case of an 86-year-old woman with a Morgani-Larrey congenital diaphragmatic hernia (HML) (2) admitted due to exacerbation of chronic baseline diarrhea. A colonoscopy with biopsies was performed, but the study was incomplete due to colonic torsion at the hepatic angle deriving from HML, with uncomplicated colonic mucosa and absence of cystic nodulations. Figure 1a. Biopsies ruled out organicity. The abdominal computed tomography (CT) scan performed revealed the accumulation of pneumoperitoneum bubbles in the distal ileum and suprahepatic wall without identification of continuity changes, or signs of visceral perforation. Figure 1b-c. The patient was diagnosed with BIN associated with an anatomical change (HML). Medical treatment was initiated with metronidazole at a dose of 1500 mg/day for 1 week, along with the patient's usual probiotics, and commercial compounds containing xyloglucan (pea protein) to restore the intestinal barrier function. (3). The patient was discharged with complete resolution of the diarrhea. No surgical intervention for her HML was required. DISCUSSION The clinical and radiological data in the presence of IN help us differentiate between severe cases and BIN, the latter being managed conservatively without the need for medical or surgical treatment. The intestinal barrier restoration measures implemented in our patient may have contributed to this resolution, although there is not enough scientific evidence to support this. The endoscopic image of nodular cysts is not always present in these cases, and the diagnosis of choice for this condition is radiological and based on exclusion. (4).
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- 2024
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29. Idiosyncratic Drug-Induced Liver Injury and Amoxicillin-Clavulanate: Spotlight on Gut Microbiota, Fecal Metabolome and Bile Acid Profile in Patients.
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Román-Sagüillo S, Quiñones Castro R, Juárez-Fernández M, Soluyanova P, Stephens C, Robles-Díaz M, Jorquera Plaza F, González-Gallego J, Martínez-Flórez S, García-Mediavilla MV, Nistal E, Jover R, and Sánchez-Campos S
- Subjects
- Humans, Male, Female, Middle Aged, Adult, Aged, Gastrointestinal Microbiome drug effects, Feces microbiology, Bile Acids and Salts metabolism, Amoxicillin-Potassium Clavulanate Combination adverse effects, Chemical and Drug Induced Liver Injury metabolism, Chemical and Drug Induced Liver Injury etiology, Metabolome drug effects
- Abstract
Several hepatic disorders are influenced by gut microbiota, but its role in idiosyncratic drug-induced liver injury (iDILI), whose main causative agent is amoxicillin-clavulanate, remains unknown. This pioneering study aims to unravel particular patterns of gut microbiota composition and associated metabolites in iDILI and iDILI patients by amoxicillin-clavulanate (iDILI-AC). Thus, serum and fecal samples from 46 patients were divided into three study groups: healthy controls (n = 10), non-iDILI acute hepatitis (n = 12) and iDILI patients (n = 24). To evaluate the amoxicillin-clavulanate effect, iDILI patients were separated into two subgroups: iDILI non-caused by amoxicillin-clavulanate (iDILI-nonAC) (n = 18) and iDILI-AC patients (n = 6). Gut microbiota composition and fecal metabolome plus serum and fecal bile acid (BA) analyses were performed, along with correlation analyses. iDILI patients presented a particular microbiome profile associated with reduced fecal secondary BAs and fecal metabolites linked to lower inflammation, such as dodecanedioic acid and pyridoxamine. Moreover, certain taxa like Barnesiella , Clostridia UCG-014 and Eubacterium spp. correlated with significant metabolites and BAs. Additionally, comparisons between iDILI-nonAC and iDILI-AC groups unraveled unique features associated with iDILI when caused by amoxicillin-clavulanate. In conclusion, specific gut microbiota profiles in iDILI and iDILI-AC patients were associated with particular metabolic and BA status, which could affect disease onset and progression.
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- 2024
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30. Choledocholithiasis in a patient carrying an intragastric balloon. Removal or direct ERCP?
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Blázquez Ávila V, Jiménez Palacios M, Villanueva Pavón RA, Espinel Díez J, and Jorquera Plaza F
- Abstract
Endoscopic retrograde cholangio-pancreatography (ERCP) is a diagnostic, therapeutic technique for the management of pancreato-biliary conditions. Technical contraindications include the presence of intraluminal foreign bodies precluding endoscope passage. Intragastric balloon (IGB) is a bariatric procedure that provides sensations of early fullness and satiety from intragastric occupation, thus leading to weight loss. While, according to guidelines, choledocholithiasis and cholangitis do not represent an indication for IGB removal in contrast to moderate-severe pancreatitis, where need for an ERCP and the procedure's technical difficulty most commonly require it. We report the case of a female patient with an IGB where ERCP was indicated. CASE REPORT: A 47-year-old woman visited the emergency room for epigastric abdominal pain radiating to her back. She had jaundice without pyrexic symptoms. At the ER an ultrasonogram revealed cholelithiasis and a dilated common bile duct (11 mm in diameter), no cause being then identified. Lab tests rule out pancreatic involvement and associated infection. The patient had an IGB (Photo 1a) implanted 5 months before the present episode. She was admitted to the gastroenterology ward with choledocholithiasis as suspected diagnosis. The study was completed by endoscopic ultrasound (EUS), which confirmed a dilated hepatocholedochal duct at 15.3 mm in diameter (Photo 1b), secondary to multiple choledochal stones. A direct ERCP procedure was initiated where the IGB precluded rectification and proper placement, which forced the use of a double-guidewire technique for cannulation (Photo 1c)5. Sphincterotomy and sphincteroplasty to 10 mm ensued, and 8 stones were removed using a balloon and then a basket catheter (Photo 1d). The patient was discharged at 24 hours after the procedure with no complications. DISCUSSION: No prior studies are available that describe the possibility of therapeutic ERCP for choledocholithiasis in IGB-carrying patients; in most cases IGB removal is taken for granted because of the procedure's technical difficulty. Our case report may well show a safe alternative to IGB removal by using less conventional cannulation techniques without higher complication rates. However, further cases are needed in order to draw significant conclusions regarding their widespread use.
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- 2024
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31. When intestinal obstruction is not a surgical condition.
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Borrego Rivas S, Domínguez Carbajo AB, Martín Izquierdo A, Díez Ruiz S, Latras Cortés I, and Jorquera Plaza F
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- Male, Middle Aged, Humans, Pain, Intestine, Small, Vomiting etiology, Intestinal Obstruction diagnostic imaging, Intestinal Obstruction etiology, Intestinal Obstruction surgery, Laparoscopy adverse effects
- Abstract
We report the case of a middle-aged man who had undergone two diagnostic laparoscopies with no significant findings after he was attended at the emergency department with cramping pain, abdominal distention and vomiting, with radiological images simulating a small bowel obstruction. After multiple hospitalisations and an extensive set of tests, including a genetic study, he was diagnosed with chronic pseudo-obstruction, an uncommon, unrecognides syndrome with high morbidity. Being aware of this pathology can make it easier to diagnose, and thereby, we can avoid unnecessary surgical interventions, because its management and treatment are mainly based on pharmacological therapy. After a proper diagnosis our patient's progression was satisfactory due to the treatment introduced, with no further hospitalisations.
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- 2023
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32. Retirform purpura, a rare chemoembolization adverse outcome.
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Borrego Rivas S, Martín Izquierdo A, Quiñones Castro R, Onecha Vallejo V, Alonso Fernández N, Alcoba Vega L, González Puente I, and Jorquera Plaza F
- Abstract
Transcatheter arterial chemoembolization (TACE) is currently one of the standards of treatment for unresectable hepatocellular carcinoma in the intermediate stage. It is a minimally invasive procedure whose adverse outcomes are well documented. Among those considered uncommon, we find skin outcomes. We report a 73-year-old man who, after undergoing TACE, develops a necrotic retiform purpura due to occlusion of the microcirculation of the cutaneous and subcutaneous tissue caused by migration of doxorubicin spheres. This is an infrequent complication, which presents with pain in the affected area. Its management is based on prevention, which is the reason why awareness of this condition is so important.
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- 2023
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33. Autoimmune hepatitis after SARS-C¬¬oV-2 vaccination.
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Díez Ruiz S, Quiñones Castro R, Alcoba Vega L, Martín Izquierdo A, González Puente I, Rodríguez Martín L, Díez Rodríguez R, and Jorquera Plaza F
- Subjects
- Humans, COVID-19 Vaccines adverse effects, SARS-CoV-2, Vaccination, COVID-19, Hepatitis, Autoimmune etiology
- Abstract
Vaccination against SARS-CoV-2 have been reported like a potential trigger of some autoimmune diseases, like autoimmune hepatitis (HAI). We present three cases of AIH developed after the administration of the SARS-Cov-2 vaccine.
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- 2023
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34. Hematoma post-endoscopic retrograde cholangiopancreatography.
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Díez Ruiz S, Latras Cortés I, Borrego Rivas S, Blázquez Ávila V, Jiménez Palacios M, Díez Rodríguez R, Espinel Díez J, and Jorquera Plaza F
- Subjects
- Humans, Cholangiopancreatography, Endoscopic Retrograde adverse effects, Cholangiopancreatography, Endoscopic Retrograde methods, Hematoma diagnostic imaging, Hematoma etiology, Liver Diseases etiology, Biliary Tract, Pancreatic Diseases complications, Gallbladder Diseases
- Abstract
Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most frequently performed procedures in the treatment of biliary-pancreatic diseases. Hematoma after ERCP is an infrequent and highly serious complication. We present three cases with hepatic hematoma after a CPRE.
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- 2023
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35. Oportunistic diagnosis based on age and hepatitis C virus clearance: an essential step to improve the overall health of the liver.
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Cabezas J, Crespo J, Aguilera A, Albillos A, Buti M, Calleja JL, Calvo Montes J, Casado Martín M, Diago Madrid M, Fernández Rodríguez C, Fernández Vázquez I, Forns X, García F, García-Samaniego J, Hernández-Guerra Aguilar M, Jorquera Plaza F, Lazarus JV, Lens S, Martró E, Molero García JM, Pena López MJ, Pineda JA, Rodríguez M, Romero Gómez M, Sanchez-Antolin G, A Serra M, and Turnes J
- Subjects
- Humans, Hepacivirus, Health Status, Hepatitis C diagnosis, Hepatitis C epidemiology, Non-alcoholic Fatty Liver Disease
- Abstract
Back in January 2022, an EASL-Lancet Commission on the impact of liver disorders in the European region commissioned by the WHO demonstrated that this condition is, actually, the second leading cause of loss of labor years in Europe after ischemic heart disease (1). This is a very relevant piece of information since this is something that is going to impact the new generations of Europeans unless a significant change is made in public health policies. Despite the advances made over the last few years in hepatitis C virus clearance-understood as a significant reduction of morbidity and mortality associated with Hepatitis B and C viruses-there are still challenges ahead to improve liver health due to the high use of alcohol, and the inseparable triad obesity / diabetes mellitus / metabolic associated fatty liver disease. Also, access to healthcare for several population groups at risk of presenting higher rates of liver disease has become a problem.
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- 2023
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36. [Relationship of demographic and dietary hygiene factors with the pathology found in outpatient colonoscopies performed in a Castilla y León Health Service center].
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Álvarez Cuenllas B, Jorquera Plaza F, Díez Rodríguez R, Vaquero Ayala L, Jiménez Palacios M, Riera Hortelano R, Fernández Pérez M, and Vivas Alegre S
- Subjects
- Humans, Male, Middle Aged, Female, Prospective Studies, Outpatients, Colonoscopy adverse effects, Health Services, Demography, Adenoma, Colorectal Neoplasms epidemiology, Colorectal Neoplasms diagnosis
- Abstract
Introduction: Background: colorectal cancer (CRC) is one of the most frequent tumors in terms of incidence and mortality. Several elements, both inherited and environmental, have been related with its pathogenesis. Aims: to analyze the influence of age, gender and nutritional factors on the diagnosis of colonic polyps and CRC. Methods: a prospective, descriptive study over outpatients from the Health Area of León who took a colonoscopy between 09/09/2012 and 06/30/2013. Patients were asked to fill a semiquantitative food frecuency questionnaire with data such a sociodemographic, toxic and dietetic facts. Differences in diagnosis according to sociodemographic and hygiene-dietetic data were analyzed with a multivariate analysis by forward stepwise logistic regression. Results: data were collected from 1390 patients. Mean age was 57.88 (15.17) years and 47.8 % were male. CRC was diagnosed in 5 % of colonoscopies, and polyps in 20.4 %, with 9.4 % of them being HRA. Risk of polyps and HRA was higher in males (26.9 % vs 14.5 %) and (12.6 % vs 6.3 %), respectively (p < 0.001). Mean age was significantly higher in patients who presented polyps (56.51 (15.45) vs 63.22 (12.69) years; p < 0.001). Among the group who reported intake of smoked and salted food, the risk of polyps doubled (2.9 % vs 6.7 %, p = 0.002). In relation to alcohol intake we found that subjects with daily alcohol consumption showed a higher incidence of polyps whe compared to occasional drinkers and teetotallers (32 % vs 20 % vs 18.6 %, p = 0.002) Conclusions: age correlated with higher risk of polyps, HRA and CRC. Moreover, male gender also was associated with a high risk of polyps and HRA. Alcohol and red and processed meat intake increased polyp risk.
- Published
- 2023
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37. Misplacement of the PEG tube through the transverse colon, an uncommon but possible complication.
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Viso Vidal D and Jorquera Plaza F
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- Colon surgery, Enteral Nutrition adverse effects, Enteral Nutrition methods, Gastrostomy adverse effects, Gastrostomy methods, Humans, Male, Middle Aged, Colon, Transverse diagnostic imaging, Fistula
- Abstract
Misplacement of the Percutaneous Endoscopic Gastrostomy (PEG) tube through the transverse colon mainly by traction is an uncommon complication probably due to inadvertent puncture of colon during PEG placement, resulting in gastrocolocutaneous fistula. Stool drainage through the stoma is usually the only symptom. We report a 52-year-old male with Wernicke-Korsakoff syndrome and PEG tube placement 7 months earlier and replacement one month ago. Due to stool drainage through the stoma was observed, he was performed a computed tomography (CT) in which PEG tube was visualized lodged in transverse colon without pneumoperitoneum associated. Due to important morbility, endoscopic management was decided. Balloon was removed through cutaneous orifice and Ovesco clip was placed simultaneously, achieving a complete closure of wall defect. Although spontaneous closure of the fistula usually happens, surgery is sometimes required, with endoscopic treatment being a less invasive and effective alternative to solve this complication.
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- 2022
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38. Gastrointestinal lymphoma, a rare endoscopic lesion.
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Latras Cortés I, Fernández Gundín MJ, Diez Ruiz S, Borrego Rivas S, Vaquero Ayala LM, Díez Rodríguez R, Jiménez Palacios M, and Jorquera Plaza F
- Subjects
- Aged, Endoscopy, Humans, Male, Anemia, Iron-Deficiency, Gastrointestinal Neoplasms diagnostic imaging, Lymphoma, Non-Hodgkin
- Abstract
We present the case of a 77-year-old male patient with iron deficiency anemia. His personal medical history is: dyslipidemia, high-grade diffuse centrofollicular lymphoma localized in the tonsil in 1984 and metastatic prostate cancer treated with hormone therapy.
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- 2022
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39. Hepatitis B and C screening in hospitalized patients with SARS-CoV-2 infection.
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Gómez Camarero J, Badia Aranda E, Quiñones Castro R, Saiz Chumillas RM, Alcoba Vega L, Díez Ruiz S, Gómez Manero N, Vinuesa Campo R, and Jorquera Plaza F
- Subjects
- Aged, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B virus, Humans, Male, Prospective Studies, SARS-CoV-2, Virus Activation, COVID-19, Hepatitis B diagnosis, Hepatitis B epidemiology, Hepatitis B prevention & control, Hepatitis C diagnosis, Hepatitis C drug therapy, Hepatitis C epidemiology
- Abstract
Aims: To evaluate the results of a hepatitis B and C screening program in hospitalized COVID-19 patients., Method: Transversal prospective study conducted in two Spanish hospitals. Patients admitted from March 1st to December 31st 2020 with a diagnosis of COVID-19 were tested for markers of hepatitis B (HBsAg, anti-HBc) and C (anti-HCV, HCV RNA) infection., Results: In this period, 4662 patients with COVID-19 were admitted to our centers: 56.3% were male, median age was 76 (0-104) years. Data regarding HBV infection was available in 2915 (62.5%) patients; 253 (8.75%) were anti-HBc+ and 11 (0.38%) HBsAg+. From these, 4 patients did not have a previous diagnosis of hepatitis B, 7 received corticosteroids and one received prophylaxis. There was one HBV reactivation. Anti-HCV was available in 2895 (62%) patients; 24 (0.83%) were positive. From these, 13 patients had a previous hepatitis C diagnosis: 10 patients had been treated with SVR, one achieved spontaneous cure and 2 did not receive treatment. From the 11 previously unknown anti-VHC+patients, 10 had a negative HCV RNA. Overall, only 3 (0.10%) patients tested RNA HCV+. However, none received HCV treatment (2 older than 90 years with comorbidities, 1 died from COVID-19)., Conclusion: Screening of hepatitis C infection in hospitalized COVID-19 patients seems less useful than expected. The low prevalence of active infection after antiviral treatments and the high age of our population limit the detection of potential candidates for treatment. HBV screening should be aimed to prevent reactivation under immunosuppressive treatments., (Copyright © 2021 Elsevier España, S.L.U. All rights reserved.)
- Published
- 2022
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40. A huge rectal ulcer due to argon plasma coagulation in a patient with radiation proctitis.
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Viso Vidal D, Jiménez Palacios M, and Jorquera Plaza F
- Subjects
- Argon, Argon Plasma Coagulation, Gastrointestinal Hemorrhage therapy, Humans, Male, Middle Aged, Ulcer etiology, Proctitis etiology, Proctitis therapy, Prostatic Neoplasms radiotherapy, Radiation Injuries complications, Radiation Injuries diagnostic imaging, Rectal Diseases etiology
- Abstract
Radiation proctitis (RP) is a complication of radiotherapy in patients with pelvic cancer. A 64-year-old male underwent brachytherapy 2 years previously due to prostate cancer. Subsequently, he developed RP which was treated with argon plasma coagulation (APC). He was subsequently hospitalized due to rectal bleeding and underwent a colonoscopy. A large deep ulcer was seen in the anterior rectum wall, in the same place where APC was performed 3 months earlier. A perforated rectal ulcer was seen via pelvic MRI. However, it was contained by the mesorrectum. Rectal ulcers after APC are uncommon, but they can develop as a result of thermal damage to an ischemic mucosa due to radiotherapy. The treatment of choice of large ulcers is surgery, with a temporary colostomy in order to aid re-epithelialization.
- Published
- 2020
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41. Serrated Lesions in patients with Inflammatory Bowel Disease.
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Viso Vidal D, Sierra Ausín M, Suárez Álvarez P, and Jorquera Plaza F
- Subjects
- Humans, Male, Middle Aged, Inflammatory Bowel Diseases pathology
- Abstract
Background: a new serrated histologic finding has recently been discovered in patients with inflammatory bowel disease (IBD), known as serrated epithelial change (SEC). Recent studies suggest that SEC is strongly associated with dysplasia., Case Report: the case was a 62-year-old male in a dysplasia-colorectal cancer screening program with periodic chromoendoscopies, with CES findings in the previous chromoendoscopy studies., Discussion: a prophylactic colectomy seems a reasonable option for patients with several serrated lesions identified via chromoendoscopy screening. Particularly, if they are extensive and poorly defined, due to the possibility of developing high-grade dysplasia or colorectal cancer (CRC) during surveillance.
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- 2019
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42. Linitis plastica of the colon due to metastases of invasive lobular breast carcinoma.
- Author
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Viso Vidal D, Villanueva Pavón R, and Jorquera Plaza F
- Subjects
- Aged, Breast Neoplasms therapy, Carcinoma, Lobular drug therapy, Colonic Neoplasms drug therapy, Fatal Outcome, Female, Humans, Linitis Plastica drug therapy, Linitis Plastica pathology, Breast Neoplasms pathology, Carcinoma, Lobular secondary, Colonic Neoplasms secondary, Linitis Plastica secondary
- Abstract
Colon metastases from breast carcinoma are relatively rare and the invasive lobular subtype tends to metastasize more frequently due to its peritoneal dissemination. A 67-year-old female with a lobular subtype breast neoplasm was treated via a surgical resection ten years previously, with subsequent radiotherapy and adjuvant chemotherapy. She is currently in clinical remission. A colonoscopy was performed due to a recent onset cachexia syndrome, which identified diffuse linitis plastica of the colon. Biopsies confirmed that it was secondary to infiltration by cancer cells of invasive lobular breast carcinoma (ILBC). In conclusion, linitis plastica of the colon may be a new presentation of colon metastases from ILBC.
- Published
- 2019
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43. An altered fecal microbiota profile in patients with non-alcoholic fatty liver disease (NAFLD) associated with obesity.
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Nistal E, Sáenz de Miera LE, Ballesteros Pomar M, Sánchez-Campos S, García-Mediavilla MV, Álvarez-Cuenllas B, Linares P, Olcoz JL, Arias-Loste MT, García-Lobo JM, Crespo J, González-Gallego J, and Jorquera Plaza F
- Subjects
- Adult, Bacterial Load, Bacteroidetes isolation & purification, Case-Control Studies, Female, Firmicutes isolation & purification, Humans, Male, Metabolic Syndrome diagnosis, Middle Aged, Non-alcoholic Fatty Liver Disease complications, Non-alcoholic Fatty Liver Disease pathology, Obesity complications, Polymerase Chain Reaction, Proteobacteria isolation & purification, Dysbiosis microbiology, Feces microbiology, Gastrointestinal Microbiome, Non-alcoholic Fatty Liver Disease microbiology, Obesity microbiology
- Abstract
Introduction: increasing evidence suggests a role of intestinal dysbiosis in obesity and non-alcoholic fatty liver disease (NAFLD). The advances in recent years with regard to the role of the gut microbiota raise the potential utility of new therapeutic approaches based on the modification of the microbiome., Objective: the aim of this study was to compare the bacterial communities in obese patients with or without NAFLD to those of healthy controls., Patients and Methods: the fecal microbiota composition of 20 healthy adults, 36 obese patients with NAFLD and 17 obese patients without NAFLD was determined by 16S ribosomal RNA sequencing using the Illumina MiSeq system., Results: the results highlighted significant differences in the phylum Firmicutes between patients with and without NAFLD, which was a determining factor of the disease and supported its possible role as a marker of NAFLD. At the genus level, the relative abundance of Blautia, Alkaliphilus, Flavobacterium and Akkermansia was reduced in obese patients, both with or without NAFLD, compared to healthy controls. Furthermore, the number of sequences from the genus Streptococcus was significantly higher in patients with NAFLD in comparison with individuals without the disease, constituting another possible marker. Comparison of bacterial communities at the genus level by a principal coordinate analysis indicated that the bacterial communities of patients with NAFLD were dispersed and did not form a group., Conclusion: in conclusion, these results indicate the role of intestinal dysbiosis in the development of NAFLD associated with obesity. There was a differential microbiota profile between obese patients, with and without NAFLD. Thus, supporting gut microbiota modulation as a therapeutic alternative for the prevention and treatment of NAFLD.
- Published
- 2019
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44. [Analysis of bone mineral density in children with celiac disease. Densitometry indications and effect of gluten-free diet].
- Author
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Iglesias Blázquez C, Jorquera Plaza F, De Paz Fernández JA, and Rodríguez Fernández LM
- Subjects
- Absorptiometry, Photon, Child, Child, Preschool, Female, Femur diagnostic imaging, Humans, Longitudinal Studies, Male, Spine diagnostic imaging, Bone Density, Celiac Disease diagnostic imaging, Celiac Disease diet therapy, Diet, Gluten-Free
- Abstract
Introduction: one of the main extradigestive manifestations of celiac disease is the decrease in bone mineral density (BMD). Bone densitometry performed with DXA is the method of choice for BMD assessment. Indications for its use in celiac children are controversial., Objective: analyzing BMD and various clinical-analytical variables in celiac children when diagnosed and after a gluten-free diet. Define a profile of patients who are more likely to present BMD involvement based on several individual characteristics, to perform DXA indications., Methods: study performed in 24 celiac children (12 boys) (age: 8.7 ± 3.3 years). Their BMD was determined at diagnosis and after a gluten-free diet using DXA. The BMD was compared in each patient in the two moments of the study and at the moment of diagnosis between groups of patients stratified according to severity criteria dependent on clinical, analytical and histological variables., Results: BMD was normal in all patients studied at the time of diagnosis and after treatment, with no difference between the two moments of the analysis. Children who presented symptomatology when diagnosed with celiac disease had lower spine and femur BMD than asymptomatic ones. The calcemia had an inverse correlation with the time of evolution of the disease before its diagnosis., Conclusions: in general, in our setting, the study of bone mineralization in celiac children is not indicated, unless there has been a prolonged clinical course before diagnosis.
- Published
- 2018
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45. Gastroenterology, a historical specialty with a great future.
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Crespo J and Jorquera Plaza F
- Subjects
- Gastroenterologists, Periodicals as Topic, Spain, Gastroenterology trends
- Abstract
The specialty of gastroenterology (SGI) deals with the conditions involving the gut (esophagus, stomach, bowels, anorectal region), liver, bile ducts, pancreas, and peritoneum, specifically with their etiology, epidemiology, pathophysiology, semiology, diagnosis, prognosis, prevention, and treatment. As shown by Dr. Curbelo et al. in the present issue of The Spanish Journal of Digestive Diseases (Revista Española de Enfermedades Digestivas), our SGI has progressively grown as a specialty training option, and is now one of the five most commonly requested residency programs.
- Published
- 2017
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46. Autochthonous acute hepatitis E: an increasingly frequent diagnosis. Clinical-epidemiological analysis of our experience.
- Author
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Monteserín Ron L, Jiménez Palacios M, Linares Torres P, Miguel Peña A, Álvarez Cuenllas B, Fernández-Natal MI, Valverde Romero E, and Jorquera Plaza F
- Subjects
- Acute Disease, Adult, Aged, Aged, 80 and over, Disease Progression, Female, Hepatitis E complications, Hepatitis E diagnosis, Hepatitis E therapy, Humans, Male, Middle Aged, Retrospective Studies, Spain epidemiology, Treatment Outcome, Endemic Diseases statistics & numerical data, Hepatitis E epidemiology
- Abstract
Background: In Europe, acute hepatitis caused by the hepatitis E virus (HEV) traditionally was an infection found in people who had travelled to endemic zones, mainly Asia and Africa. However, a growing number of sporadic autochthonous cases are now being diagnosed in the Western world., Objective: To analyze the cases of acute HEV hepatitis diagnosed in our setting, with the identification of the clinical-epidemiological characteristics., Material and Methods: We included the cases of acute HEV hepatitis diagnosed (positive anti-HEV IgM and/or HEV RNA present in serum) between January 2008 and December 2014. Different clinical, epidemiological and evolutive parameters were analyzed., Results: A total of 23 patients were identified, all originating from Spain. Fourteen cases (60.87%) presented jaundice and marked cytolysis at the time of diagnosis (aspartate aminotransferase [AST] 1,106.91 U/l and alanine aminotransferase [ALT] 1,407.04 U/l). Twenty-two cases were regarded as autochthonous, and one patient had travelled to China three months before. The mean time to resolution was 11.2 weeks. Some autoimmune markers were positive in 43.5% of the patients. Two subjects were diagnosed with previous chronic liver disease and were classified as "acute-on-chronic liver failure" (ACLF), one died and the other underwent liver transplantation., Conclusion: Acute HEV hepatitis in our setting is an autochthonous condition that is probably underdiagnosed, manifesting with jaundice and cytolysis. Autoimmune marker positivity is an epiphenomenon, which in some cases complicates the diagnosis.
- Published
- 2017
- Full Text
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47. [Vitamin D deficiency in chronic liver disease, clinical-epidemiological analysis and report after vitamin d supplementation].
- Author
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Fernández Fernández N, Linares Torres P, Joáo Matias D, Jorquera Plaza F, and Olcoz Goñi JL
- Subjects
- Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Humans, Male, Middle Aged, Prevalence, Liver Diseases complications, Vitamin D administration & dosage, Vitamin D Deficiency complications
- Abstract
Introduction: Vitamin D (VD) is known to have multiple extra-skeletal health functions. There is emerging interest in exploring the relationship between vitamin D and chronic liver disease (CLD)., Objectives: To determine the prevalence of VD deficiency in patients with CLD in our setting and to assess whether VD supplementation influences plasma levels and is associated with improved liver function., Material and Methods: We conducted a study in 2 phases. First, we analysed clinical and epidemiological characteristics in 94 patients with CLD; second, different doses of calcifediol (25-OH-VD) were administered to patients with VD deficiency (<20ng/mL) and insufficiency (20-30ng/mL). Plasma concentrations and liver function (Child-Pugh and MELD) at the end of treatment were compared with baseline data., Results: Deficient or insufficient VD levels were found in 87% of the patients, with an average concentration of 18.8ng/mL. Levels were lower in patients with cirrhosis (15.9ng/mL) (P=.002) and in alcoholic liver disease. VD levels were inversely proportional to the degree of liver function: Child A (16.52ng/mL) vs C (7.75ng/mL). After VD supplementation, optimal serum levels were achieved in 94% of patients and significant improvements were observed in platelet count, albumin levels (P<.05) and functional status assessed by the Child-Pugh scale (P<.05)., Conclusion: Given the high prevalence of VD deficiency or insufficiency, the need for screening should be considered in the population with CLD. VD supplementation could be safe and effective., (Copyright © 2015 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.)
- Published
- 2016
- Full Text
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48. [Reactivation of pulmonary tuberculosis during treatment with triple therapy for hepatitis C].
- Author
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Rodríguez-Martín L, Linares Torres P, Aparicio Cabezudo M, Fernández-Fernández N, Jorquera Plaza F, Olcoz Goñi JL, Gutiérrez Gutiérrez E, and Fernández Morán EM
- Subjects
- Hepacivirus, Humans, Male, Middle Aged, Hepatitis C drug therapy, Tuberculosis, Pulmonary etiology
- Published
- 2016
- Full Text
- View/download PDF
49. [Upper gastrointestinal bleeding due to an uncommon lymphoproliferative process].
- Author
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Rodríguez-Martín L, Aparicio Cabezudo M, Álvarez-Cuenllas B, Linares Torres P, Hernando Martín M, López-Cuesta D, Jorquera Plaza F, and Olcoz Goñi JL
- Subjects
- Aged, 80 and over, Humans, Male, Gastrointestinal Hemorrhage etiology, Lymphoproliferative Disorders complications
- Published
- 2016
- Full Text
- View/download PDF
50. Vitamin D levels and bone turnover markers are not related to non-alcoholic fatty liver disease in severely obese patients.
- Author
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Díez Rodríguez R, Ballesteros Pomar MD, Calleja Fernández A, Calleja Antolin S, Cano Rodríguez I, Linares Torres P, Jorquera Plaza F, and Olcoz Goñi JL
- Subjects
- Adult, Biomarkers metabolism, Bone Density, Female, Humans, Male, Middle Aged, Osteocalcin metabolism, Parathyroid Hormone metabolism, Bone Remodeling, Non-alcoholic Fatty Liver Disease metabolism, Obesity, Morbid metabolism, Vitamin D metabolism
- Abstract
Background: Morbidly obese patients usually present vitamin D deficiency or secondary hyperparathyroidism. Low vitamin D levels have been recently related to non-alcoholic fatty liver disease (NAFLD). The aim of this study was to analyse the relationship between vitamin D, bone turnover markers and non-alcoholic fatty liver disease and metabolic syndrome in severely obese patients., Methods: One hundred and ten patients who underwent bariatric surgery were included. Liver biopsy was taken during surgery. Two univariate analyses were carried out in order to i) analyse the relationship between liver histology and vitamin D-bone turnover markers (intact parathyroid hormone (PTH), osteocalcin and Carboxy-terminal collagen crosslinks) and ii) establish the association between metabolic syndrome components-insulin resistance (HOMA) and vitamin D-bone turnover markers., Results: 70% of the patients had lower levels of vitamin D or secondary hyperparathyroidism. None of the components of liver histology were associated with levels of vitamin D or with bone turnover parameters. Patients with metabolic syndrome showed lower levels of PTH and osteocalcin (72,42 (29,47) vs 61.25(19.59) p-Value: 0.022; 19.79 (10.43) vs 16.87(10.25) p-Value: 0,028, respectively). HOMA was not related to Vitamin D or bone turnover markers., Conclusion: Low levels of vitamin D or hyperparathyroidism are common in severely obese patients. Vitamin D and bone metabolism markers were associated neither to NAFLD nor with metabolic syndrome in our series of obese morbid patients., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
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