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RESUMO Introducao: A prematuridade e considerada uma das principais causas da morbimortalidade neonatal, sendo prematuro todo bebe nascido antes de completar 37 semanas gestacionais. Sabe-se que a prematuridade, o tempo de internacao e as comorbidades neonatais refletem no desenvolvimento motor e psicossocial infantil. Objetivo: Descrever aspectos do desenvolvimento motor e socioemocional de lactentes que tiveram nascimento prematuro, entre 27 e 35 semanas. Metodo: Estudo serie de casos, realizado com quatro lactentes (dois meninos e duas meninas) entre 06 e 20 meses de idade cronologica. O protocolo foi dividido em duas fases: Fase 1- entrevista inicial e avaliacao dos lactentes por meio da Escala Motora Infantil de Alberta e o questionario ASQ-SE ( Social-Emotional ); Fase 2- Calculo da idade corrigida e analise dos dados realizada de modo descritivo. Resultados: Nao foram encontrados escores que indiquem alteracoes no desenvolvimento motor e no comportamento que justifiquem o encaminhamento para profissionais especializados dos lactentes avaliados. As escalas foram utilizadas em sua versao original, em ingles, seguindo os manuais normativos. Conclusao: Apesar de nao encontrado resultados com grandes diferencas entre o desenvolvimento de lactentes pre-termos e termos, o acompanhamento multiprofissional tanto dos lactentes quanto das maes, e de extrema importância para rastreio de possiveis adversidades durante a vida. Alem disso, estudos ainda precisam ser realizados para complementacao das avaliacoes e melhor compreensao dos questionarios, para que seja possivel o rastreio precoce de possiveis atrasos no desenvolvimento infantil.

Agradecimentos: The author authors thank the financial supported by the "National Council for Scientific and Technological Development—CNPq" (Process 142364/2016-9) and "São Paulo Research Foundation—FAPESP" (Process no. 2018/20532-0). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. This work is financially supported by the "National Council for Scientific and Technological Development—CNPq" (Process 142364/2016-9) and "São Paulo Research Foundation—FAPESP" (Process no. 2018/20532-0). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. This work has also been supported by the "National Council for Scientific and Technological Development—CNPq" (Universal Call MCTIC/CNPq 28/2018 process no. 431272/2018-2) and was conducted within the scope of grant #2015/20630-4, São Paulo Research Foundation (FAPESP) Abstract: This work compared the catalytic performance of the amorphous Nb2O5 (NB) and 12 wt% Nb2O5/Al2O3 (NB-AL) catalysts for the xylose dehydration to furfural carried out for 6 h at 140 and 160 degrees C using water or a 1:0.8 (v/v) water/isopropanol mixture as solvents. The solids were characterized by XRD, N-2 adsorption, TGA, XPS, TPD-NH3 and FTIR-Pyridine. Results indicated a specific surface area of 144 and 108 m(2)/g and an average pore diameter of 44 and 76 angstrom to NB and NB-AL respectively. The solids presented similar density of acid sites (6.0 for NB and 5.7 mu molNH(3)/m(2) for NB-AL), but different strength distribution of the acid sites. Moreover, the fraction of Bronsted acid sites on NB was 27%, whereas on NB-AL it was only 2%. Concerning the catalytic tests, the highest conversion of xylose for NB and NB-AL (99.0 and 91.1%, respectively) was achieved for the reactions at 160 degrees C in water/isopropanol mixture, whilst the highest selectivities to furfural were obtained in reactions with water at 160 degrees C (60.1% to NB and 35.1% to NB-AL). Finally, using water as solvent, the selectivity to furfural increased with both catalysts at the highest temperature, though the carbon balance decreased CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES Fechado

RESUMOIntrodução: A prematuridade é considerada uma das principais causas da morbimortalidade neonatal, sendo prematuro todo bebê nascido antes de completar 37 semanas gestacionais. Sabe-se que a prematuridade, o tempo de internação e as comorbidades neonatais refletem no desenvolvimento motor e psicossocial infantil. Objetivo: Descrever aspectos do desenvolvimento motor e socioemocional de lactentes que tiveram nascimento prematuro, entre 27 e 35 semanas. Método: Estudo série de casos, realizado com quatro lactentes (dois meninos e duas meninas) entre 06 e 20 meses de idade cronológica. O protocolo foi dividido em duas fases: Fase 1- entrevista inicial e avaliação dos lactentes por meio da Escala Motora Infantil de Alberta e o questionário ASQ-SE (Social-Emotional); Fase 2- Cálculo da idade corrigida e análise dos dados realizada de modo descritivo. Resultados: Não foram encontrados escores que indiquem alterações no desenvolvimento motor e no comportamento que justifiquem o encaminhamento para profissionais especializados dos lactentes avaliados. As escalas foram utilizadas em sua versão original, em inglês, seguindo os manuais normativos. Conclusão: Apesar de não encontrado resultados com grandes diferenças entre o desenvolvimento de lactentes pré-termos e termos, o acompanhamento multiprofissional tanto dos lactentes quanto das mães, é de extrema importância para rastreio de possíveis adversidades durante a vida. Além disso, estudos ainda precisam ser realizados para complementação das avaliações e melhor compreensão dos questionários, para que seja possível o rastreio precoce de possíveis atrasos no desenvolvimento infantil.

Ammonia synthesis reactors operate in conditions of high pressure and high temperature. Consequently, the flow inside these reactors always presents interaction between components in the feed mixture. A modeling accounts these interactions with pressure, temperature and the molar fraction is essential to converter simulation more realistic. The compositional approach based on cubic equations of state provides the influences of the component of a gas mixture using mixing rules and binary interaction parameters. This multicomponent description makes the model more robust and reliable for properties mixture prediction. In this work, two models of ammonia synthesis reactors were simulated: adiabatic and autothermal. The fitted expression of Singh and Saraf was used. The adiabatic reactor model presented a maximum relative error of 1.6% in temperature and 11.4% in conversion while the autothermal reactor model presents a maximum error of 2.7% in temperature, when compared to plant data. Furthermore, a sensitivity analysis in input variables of both converter models was performed to predict operational limits and performance of the Models for Ammonia Reactor Simulation (MARS).

Orientador: Maria Teresa Moreira Rodrigues Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Química Resumo: O processo de síntese de amônia completou 100 anos em 2013. Esta foi uma das maiores invenções do século XX. Além disso, este processo possui uma elevada gama de temperaturas e pressões, indo de 1 atm a 300 atm e de 200 K até 800 K (na qual a reação pode ocorrer). A produção de amônia acontece em reatores de 150 a 300 atm e de 600 a 810 K, com 30 % de conversão por passe, pois a reação é altamente exotérmica. Mais ainda, a amônia é um gás polar e hidrogênio é um gás quântico nessas condições. Logo, a predição de composição, temperatura e de pressão dentro de reatores de amônia usando modelos apropriados se faz importante. Muitas leis de reação foram propostas. Porém, muitas dessas expressões usavam atividade química sem computar interações entre os componentes. Dessa forma, a modelagem de reatores de amônia utilizando um modelo termodinâmico rigoroso foi proposta neste trabalho. As expressões de Peng e Robinson e de Soave Redlich Kwong foram usadas na taxa de reação proposta por Singh e Saraf. Dois modos de operação foram modelados: adiabático (no qual a reação não troca calor com a vizinhança) e autotérmico (operando não isotermicamente). A atividade catalítica foi ajustada a modelagem por equações de estado. Os dois modelos de reatores foram comparados com dados de planta reais e apresentaram boa concordância. O modelo adiabático apresentou um erro máximo relativo de 1.6 % com a temperatura e de 11.4 % com a conversão. Por outro lado, o modelo autotérmico teve um erro máximo de 2.7 % com a temperatura. Posteriormente uma análise de sensitividade foi realizada em variáveis de entrada de ambos os modelos. A operação adiabática se mostrou mais sensível à variação de pressão e temperatura, enquanto a autotérmica apresentou maiores conversões e melhor remoção de energia. Na parte final, uma estimativa de propriedades na camada limite mássica foi realizada. Os valores de difusão mássica foram pequenos devido à elevada pressão, contudo a resistência externa à transferência de massa se mostrou significativa. Mesmo assim, a maior resistência no reator de síntese de amônia é interna a partícula catalítica Abstract: Ammonia synthesis process completed 100 years in 2013. It was one of the most important inventions in 20th century. Moreover, the process has a variety of temperatures and pressures, going from 1 atm to 300 atm, and from 200 K to 810 K. The ammonia production takes place in reactors from 150 to 300 atm and 600 to 800 K with 30 % of conversion, because it is highly exothermic. Besides, ammonia is a polar gas and hydrogen is a quantic gas in these conditions. Therefore, the prediction of composition, temperature and pressure inside ammonia converters using appropriate models is important. Furthermore, many reaction rates were proposed for ammonia synthesis. However, most of the expressions used chemical activity without computing compositional interactions between components. So, the modeling of reactors using a rigorous thermodynamic model was proposed. The Peng Robinson and Soave Redlich Kwong expressions were used in Singh and Saraf rate expression. Two modes of operations were modeled: adiabatic (which reaction releases heat without removal) and autothermal (non isothermal operation). The catalyst activity was fitted to EoS modeling. Both models were validated with plant data and they presented good reliability. The adiabatic model presented maximum error of 1.6 % with temperature and 11.4 % with conversion. On the other hand, autothermal model presented maximum error of 2.7 % with temperature. Moreover, the sensitivity analysis of input variables was proposed in both models. The adiabatic operation showed more sensitive to inlet pressure and temperature variations, while the autothermal reactor presented higher conversions and better energy removal. In final part, the estimation of properties in mass boundary layer were made. The values of mass diffusion were low due to high pressure and external resistance was significant. However, when it was compared to internal resistance, the resistance computed by effectiveness factor was dominant in ammonia synthesis reactor Mestrado Sistemas de Processos Químicos e Informática Mestre em Engenharia Química CNPQ 131744/2016-0

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:22:23Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:40:19Z : No. of bitstreams: 1 2-s2.0-34548163333.pdf: 162369 bytes, checksum: bc423e2c10f16696bfce6fea68fbce4f (MD5) Made available in DSpace on 2014-05-27T11:22:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-01-01 The aim of this study was to determine whether there are differences in the attitudes of Dentistry School Professors from two universities, one private and one public concerning HIV-positive patients or HIV-positive health care professionals. A questionnaire Was handled to all profession at the Araçatuba Dental School of São Paulo State University - FOA-UNESP (public) and Lins Dental School of the Piracicaba Methodist University - FOL-UNIMEP (private). When asked if they would be willing to be treated by an HIV-infected health care professional, 38.9% of the 77 professors at FOA-UNESP replied that they would accept only non-invasive treatments and 13% would not accept any kind of treatment; the same applied to 42.4% and 15.2% of the 33 FOL-UNIMEP professors. Among the 54 professors at FOA-UNESP and 27 at FOL-UNIMEP providing clinical service, only 31.5% and 18.5% stated that they treat HIV-infected persons like any other patient. The results were very similar in both schools. Although they reported that they taught their students not to act in a discriminatory manner towards HIV-positive patient the professors themselves showed prejudice towards infected patients and professionals. Consequently, this topic trust be further debated in the academic milieu. Department of Preventive and Social Dentistry UNESP - São Paulo State University Araçatuba School of Dentistry, Araçatuba, São Paulo Preventive and Social Dentistry Program UNESP - São Paulo State University Araçatuba School of Dentistry, Araçatuba, São Paulo , R. Jose Bonifacio, 1193, Araçatuba-SP 16015-150 Department of Preventive and Social Dentistry UNESP - São Paulo State University Araçatuba School of Dentistry, Araçatuba, São Paulo Preventive and Social Dentistry Program UNESP - São Paulo State University Araçatuba School of Dentistry, Araçatuba, São Paulo

A general one-pot synthesis for 2 H-chromenes is reported from ORTHO-naphthoquinones and allyltriphenylphosphonium salts, [(RMeC=CHCH 2 )Ph 3 P] + Br - , in the presence of aqueous NaOH and chloroform at room temperature.

The synthesis of new carbonyl and fluoroalkyl o-quinone methides from β-lapachone is reported.

A general one-pot synthesis for 2 H-chromenes is reported from ORTHO-naphthoquinones and allyltriphenylphosphonium salts, [(RMeC=CHCH 2 )Ph 3 P] + Br - , in the presence of aqueous NaOH and chloroform at room temperature.

Fundo Mackenzie de Pesquisa The improvement and the scientific search for new productions and research regarding the questions that accumulate of stocks the process of pertaining to school inclusion are each time more present, in the intention of better understanding and making possible together responsible action to the educational process of people with disability. Thinking about this, the present work intend to point out the importance of the support to the school, the professors and the students that they lives deeply this process, with the purpose to guarantee better conditions of participation and educational exploitation. For being extensive the different ways of intervention and support to the school, this work had as objective identify the expectations of the professors with relation to the performance of the physiotherapist in the proposal of pertaining to the school inclusion of students with physical disability with or without neurological deficiency to ratify the action of this professional at the moments of to play and motor activities in the school. The research was happened in Barueri City, in 14 schools of the Infantile Education, having the participation of 16 professors who was teaching for students with physical disability. The result of the research had been presented through quantitative analyses and qualitative analyses, from the application of a questionnaire for each participant. With the gotten results , it was identified the necessity of support to the schools, the professors and the students, since it does not have offered services and supports, and is many the difficulties of the professors in becoming accomplishes the participation of the students who present physical deficiency at the moments of to play and motor activities. The physiotherapist, according to expectations of the professors, can play important role in this challenge, being a professional capable to integrate a work in set with the professor in favor of the student who lives deeply the process of pertaining to school inclusion. O aprimoramento e a busca por novas produções e pesquisas científicas a respeito das questões que abarcam o processo de inclusão escolar estão cada vez mais presentes, no intuito de melhor compreender e possibilitar ações responsáveis junto ao processo educacional de pessoas com deficiência. Pensando nisso, o presente trabalho salienta a importância do apoio à escola, aos professores e aos alunos que vivenciam este processo, com a finalidade de garantir melhores condições de participação e aproveitamento educacional. Por serem amplas as diferentes maneiras de intervenção e apoio à escola, este trabalho teve como objetivo identificar as expectativas dos professores com relação à atuação do fisioterapeuta na proposta de inclusão escolar de alunos com deficiência física com ou sem comprometimentos neurológicos, ressaltando a ação deste profissional nos momentos de brincadeiras e atividades motoras na escola. A pesquisa foi realizada no município de Barueri, em 14 escolas da Educação Infantil, tendo a participação de 16 professores que lecionavam para alunos com deficiência física. Os dados da pesquisa foram apresentados através de análises quantitativas e análises qualitativas, a partir da aplicação de um questionário para cada participante. Diante dos resultados obtidos, identificou-se a grande necessidade de apoio às escolas, aos professores e aos alunos, visto que não há serviços e suportes oferecidos, e são muitas as dificuldades dos professores em tornar efetiva a participação dos alunos que apresentam deficiência física nos momentos de brincadeiras e atividades motoras. O fisioterapeuta, segundo as expectativas dos professores, pode desempenhar importante papel neste desafio, sendo um profissional capaz de integrar um trabalho em conjunto com o professor a favor do aluno que vivencia o processo de inclusão escolar.

Starting from alpha- and beta-lapachones, in this work we compared the biological and theoretical profile of several oxyran derivatives of lapachone as potential trypanocidal agents. Our biological results showed that the oxyrans tested act as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. The oxyran derivative of alpha-lapachone (7a) showed to be one of the most potent compounds. In our molecular modeling study, we analyzed the C-ring moiety and the redox center of beta-lapachone molecule as the moieties responsible for the trypanocidal and cytotoxic effects on mammalian cell line. The computational methods used to delineate the structural requirements for the trypanocidal profile pointed out that the transposition of the C-ring moiety of beta-lapachone, combined with its oxyran ring, introduced important molecular requirements for trypanocidal activity in the HOMO energy, HOMO orbital coefficient, LUMO density, electrostatic potential map, dipole moment vector, and calculated logP (clogP) parameter. This study could lead to the development of new antichagasic medicines based on alpha-lapachone analogs.

The assignment of the diazo site in products of the reaction of p-toluenesulfonylhydrazine with β-lapachone, 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione, and other 1,2-naphthoquinones in methanol solution at room temperature has been accomplished using 1H,13C HMBC and 1H,15N HMBC NMR experiments. Only one diazo-naphthalenone product was isolated in yields ranging from 50–100% from each reaction. The site of diazo substitution of β-lapachone and derivatives is the 1-position, in contrast to substitution at the 2-position in 4-MeO-1,2-naphthoquinone. Steric factors, rather than electronic factors, control the reaction site. Along with 2-diazo-1(2H)-naphthalenone, an additional product isolated from the reaction of p-toluenesulfonylhydrazide with 1,2-naphthoquinone was 2-diazo-4-hydroxy-1(2H)-naphthalenone. Confirmation of the formation of 6-diazo-2,2-dimethyl-2,3,4,6-tetrahydro-2H-benzo[h]cromen-5-one, obtained from β-lapachone, was achieved using single crystal X-ray diffraction. Copyright © 2006 John Wiley & Sons, Ltd.

The investigation of trypanocidal effects against Trypanosoma cruzi and cytotoxicity in VERO cell line of several oxyranes structurally related to beta-lapachone, nor-beta-lapachone, alpha-lapachone, and 4-methoxy-1,2-naphthoquinone is described. It was found that the oxyranes 10 derived from alpha-lapachone showed an approximately the same trypanocidal activity of beta-lapachone. In addition, all the oxyranes showed less cytotoxicity than the corresponding naphthoquinones.

Made available in DSpace on 2014-06-11T19:27:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2005Bitstream added on 2014-06-13T20:36:13Z : No. of bitstreams: 1 silva_fsjfb_me_araca.pdf: 451043 bytes, checksum: 17eeba236e4505170644e55650923f63 (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) O Agente Comunitário de Saúde-ACS é elo fundamental no processo de articulação e interlocução entre a Equipe de Saúde da Família-ESF, o serviço local e a comunidade assistida. Atuando no nível da atenção primária à saúde é socialmente importante na promoção e ampliação dos cuidados à Saúde Bucal-SB. Sabendo disso, objetivou-se conhecer o perfil deste profissional incluso no Programa Saúde da Família-PSF de Araçatuba-SP no que tange aos parâmetros estabelecidos pelo Ministério da Saúde-MS, e ainda a opinião dos mesmos frente às dificuldades, satisfações e motivos sobre o trabalho que realizam. Enquanto membro ativo na Equipe de Saúde Bucal-ESB propôs-se analisar sua integração com os profissionais e as ações desenvolvidas nesta área. Ultilizou-se uma abordagem quantiqualitativa através de um questionário semi-estruturado e auto-administrado, com pós-categorização das respostas. Notou-se que, sendo a maioria do sexo feminino, apresentaram idade propícia, escolaridade elevada, residência na área com tempo favorável, e responsabilidade por um número estimado de famílias. A contratação ocorreu adequadamente, e apesar de variável e contratos provisórios, muitos estão desde o início do PSF. Grande parte participou da capacitação introdutória, porém não há continuidade desta. Executam atividades próprias de suas atribuições, com excessiva ênfase em algumas práticas e total ausência em outras. Na opinião da maioria, às dificuldades decorrem de fatores climáticos, receptividade, agendamento e encaminhamento, e as satisfações de sentir-se socialmente útil, e da valorização dada pela ESF e comunidade em resposta ao resultado de conscientização e mudança de hábito alcançado... The Community Health Agent (CHA) is the fundamental link in the process of articulation and communication between the Family Health Team (FHT), the local service, and the assisted community. Working in the primary health care, the agent is socially important to promote and expand the care to Dental Health (DH). With this in mind, we aimed at knowing the profile of the professional participating in the Family Health Program (FHP) in Araçatuba-SP in regard to the parameters established by the Ministry of Health (MH), and their opinions concerning the difficulties, satisfactions, and motivations for the work they perform. Because CHAs are active members in Dental Health Team (DHT), we proposed to analyze their integration with the other professionals and the actions developed in that area. A quantiqualitative approach was made by means of a self-administered semistructured questionnaire, with post-categorization of the responses. It was observed that, most of them were female, were in the required age group, had high education level, lived in the area for a reasonable time, and were responsible for an estimated number of families. The CHA hiring occurred within the legal parameters, and despite some variations and a few provisional contracts, many have participated in the FHP since its early days. Great part of them participated in the introductory training program. However, there is no continuing training. They carry out the activities within their competence, with excessive emphasis on certain practices and absolute absence of others. In the opinion of most of them, the difficulties arise from the weather conditions, receptivity, appointment making and referral...(Complete abstract click electronic access below)