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Sub-terahertz communications (100-300 GHz) are explored today as a candidate technology to enable extremely high-rate, low-latency data services and high-resolution sensing in beyond-fifth-generation (beyond-5G) wireless networks. However, these sub-terahertz wireless systems will often have to operate in the near field, where the signal propagation does not follow canonical far-field models, including the commonly used free space path loss equation. Instead, the signal propagation in the near field follows more complex patterns that are not well-captured with analytical far-field models standardized for 5G research. Moreover, state-of-the-art beamforming solutions exploited heavily in fourth-generation (4G) and 5G networks are notably less efficient in the near field. In this article, the near-field sub-terahertz channel is accurately measured and analyzed. In addition to state-of-the-art beamforming, the article also analyzes the sub-terahertz channel measurements when using near-field-specific Bessel beams that demonstrate fewer power fluctuations in the near field in addition to higher focusing gain. Novel distance-centric and angle-centric dependencies reported in this article may serve as a reference when developing next-generation channel models for sixth-generation (6G) and beyond-6G near-field sub-terahertz wireless systems., (© 2024. The Author(s).)

As human progenitor cells differentiate into neurons, the activities of many genes change; these changes are maintained within a narrow range, referred to as genome homeostasis. This process, which alters the synchronization of the entire expressed genome, is distorted in neurodevelopmental diseases such as schizophrenia. The coordinated gene activity networks formed by altering sets of genes comprise recurring coordination modules, governed by the entropy-controlling action of nuclear FGFR1, known to be associated with DNA topology. These modules can be modeled as energy-transferring circuits, revealing that genome homeostasis is maintained by reducing oscillations (noise) in gene activity while allowing gene activity changes to be transmitted across networks; this occurs more readily in neuronal committed cells than in neural progenitors. These findings advance a model of an "entangled" global genome acting as a flexible, coordinated homeostatic system that responds to developmental signals, is governed by nuclear FGFR1, and is reprogrammed in disease.

Cavity magnonics is an emerging research area focusing on the coupling between magnons and photons. Despite its great potential for coherent information processing, it has been long restricted by the narrow interaction bandwidth. In this Letter, we theoretically propose and experimentally demonstrate a novel approach to achieve broadband photon-magnon coupling by adopting slow waves on engineered microwave waveguides. To the best of our knowledge, this is the first time that slow wave is combined with hybrid magnonics. Its unique properties promise great potentials for both fundamental research and practical applications, for instance, by deepening our understanding of the light-matter interaction in the slow wave regime and providing high-efficiency spin wave transducers. The device concept can be extended to other systems such as optomagnonics and magnomechanics, opening up new directions for hybrid magnonics.

Graphene-based Field-Effect Transistors (FETs) integrated with microstrip patch antennas offer a promising approach for terahertz signal radiation. In this study, a dual-stage simulation methodology is employed to comprehensively investigate the device's performance. The initial stage, executed in MATLAB, delves into charge transport dynamics within a FET under asymmetric boundary conditions, employing hydrodynamic equations for electron transport in the graphene channel. Electromagnetic field interactions are modeled via Finite-Difference Time-Domain (FDTD) techniques. The second stage, conducted in COMSOL Multiphysics, focuses on the microstrip patch antenna's radiative characteristics. Notably, analysis of the S11 curve reveals minimal reflections at the FET's resonant frequency of 1.34672 THz, indicating efficient impedance matching. Examination of the radiation pattern demonstrates the antenna's favorable directional properties. This research underscores the potential of graphene-based FETs for terahertz applications, offering tunable impedance matching and high radiation efficiency for future terahertz devices.

The field of wireless communication has witnessed tremendous advancements in the past few decades, leading to more pervasive and ubiquitous networks. Human bodies are continually exposed to electromagnetic radiation, but typically this does not impact the body as the radiation is non-ionizing and the waves carry low power. However, with progress in the sixth generation (6G) of wireless networks and the adoption of the spectrum above 100 GHz in the next few years, higher power radiation is needed to cover larger areas, exposing humans to stronger and more prolonged radiation. Also, water has a high absorption coefficient at these frequencies and could lead to thermal effects on the skin. Hence, there is a need to study the radiation effects on human tissues, specifically the photothermal effects. In this paper, we present a custom-built, multi-physics model to investigate electromagnetic wave propagation in human tissue and study its subsequent photothermal effects. The proposed finite-element model consists of two segments-the first one estimates the intensity distribution along the beam path, while the second calculates the increase in temperature due to the wave distribution inside the tissue. We determine the intensity variation in the tissue using the radiative transfer equation and compare the results with Monte Carlo analysis and existing analytical models. The intensity information is then utilized to predict the rise in temperature with a bio-heat transfer module, powered by Pennes' bioheat equation. The model is parametric, and we perform a systematic photothermal analysis to recognize the crucial variables responsible for the temperature growth inside the tissue, particularly for terahertz and near-infrared optical frequencies. Our numerical model can serve as a benchmark for studying the high-frequency radiation effects on complex heterogeneous media such as human tissue., (© 2023. Springer Nature Limited.)

The field of sub-terahertz wireless communications is advancing rapidly, with major research efforts ramping up around the globe. To address some of the significant hurdles associated with exploiting these high frequencies for broadband and secure networking, systems will require extensive new capabilities for sensing their environment and manipulating their broadcasts. Based on these requirements, a vision for future wireless systems is beginning to emerge. In this Perspective article, we discuss some of the prominent challenges and possible solutions which are at the forefront of current research, and which will contribute to the architecture of wireless platforms beyond 5G., (© 2023. The Author(s).)

One of the key distinctions between legacy low-frequency wireless systems and future THz wireless transmissions is that THz links will require high directionality, to overcome the large free-space path loss. Because of this directionality, optical phenomena become increasingly important as design considerations. A key example lies in the strong dependence of angular radiation patterns on the transmission frequency, which is manifested in many different situations including common diffraction patterns and the emission from leaky-wave apertures. As a result of this effect, the spectral bandwidth at a receiver is nonlinearly dependent on the receiver's angular position and distance from the transmitter. In this work, we explore the implications of this type of effect by incorporating either a diffraction grating or a leaky wave antenna into a communication link. These general considerations will have significant implications for the robustness of data transmissions at high frequencies., (© 2022. The Author(s).)

Terahertz (THz) plasma oscillations represent a potential path to implement ultrafast electronic devices and circuits. Here, we present an approach to generate on-chip THz signals that relies on plasma-wave stabilization in nanoscale transistors with specific structural asymmetry. A hydrodynamic treatment shows how the transistor asymmetry supports plasma-wave amplification, giving rise to pronounced negative differential conductance (NDC). A demonstration of these behaviors is provided in InGaAs high-mobility transistors, which exhibit NDC in accordance with their designed asymmetry. The NDC onsets once the drift velocity in the channel reaches a threshold value, triggering the initial plasma instability. We also show how this feature can be made to persist beyond room temperature (to at least 75 °C), when the gating is configured to facilitate a transition between the hydrodynamic and ballistic regimes (of electron-electron transport). Our findings represent a significant step forward for efforts to develop active components for THz electronics.

During the development of mouse embryonic stem cells (ESC) to neuronal committed cells (NCC), coordinated changes in the expression of 2851 genes take place, mediated by the nuclear form of FGFR1. In this paper, widespread differences are demonstrated in the ESC and NCC inter- and intra-chromosomal interactions, chromatin looping, the formation of CTCF- and nFGFR1-linked Topologically Associating Domains (TADs) on a genome-wide scale and in exemplary HoxA-D loci. The analysis centered on HoxA cluster shows that blocking FGFR1 disrupts the loop formation. FGFR1 binding and genome locales are predictive of the genome interactions; likewise, chromatin interactions along with nFGFR1 binding are predictive of the genome function and correlate with genome regulatory attributes and gene expression. This study advances a topologically integrated genome archipelago model that undergoes structural transformations through the formation of nFGFR1-associated TADs. The makeover of the TAD islands serves to recruit distinct ontogenic programs during the development of the ESC to NCC.

On-chip integrated laser sources of structured light carrying fractional orbital angular momentum (FOAM) are highly desirable for the forefront development of optical communication and quantum information-processing technologies. While integrated vortex beam generators have been previously demonstrated in different optical settings, ultrafast control and sweep of FOAM light with low-power control, suitable for high-speed optical communication and computing, remains challenging. Here we demonstrate fast control of the FOAM from a vortex semiconductor microlaser based on fast transient mixing of integer laser vorticities induced by a control pulse. A continuous FOAM sweep between charge 0 and charge +2 is demonstrated in a 100 ps time window, with the ultimate speed limit being established by the carrier recombination time in the gain medium. Our results provide a new route to generating vortex microlasers carrying FOAM that are switchable at GHz frequencies by an ultrafast control pulse., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest., (© The Author(s) 2020.)

Epsilon-near-zero (ENZ) materials display unique properties, and among them, large local field enhancement at ENZ frequency is of particular interest for many potential applications. In this Letter, we introduce the concept that a combination of epsilon-near-zero and surface plasmon polariton modes can be excited over an interface between a dielectric and a single ENZ layer in a specific frequency region, which can lead to extreme enhancement of local electric field. We demonstrate it with a systematic numerical simulation using finite element analysis and consider two configurations (Kretschmann configuration and a grating configuration), where an indium tin oxide (ITO) layer is sandwiched between two dielectric slabs. We confirm the formation of a hybrid mode at the ITO-dielectric interface at the wavelength of ENZ, as the ITO layer thickness reduces. The hybrid mode provides both high confinement and long propagation distance, which makes it more attractive for many applications than just a pure ENZ mode.

The orbital angular momentum (OAM) intrinsically carried by vortex light beams holds a promise for multidimensional high-capacity data multiplexing, meeting the ever-increasing demands for information. Development of a dynamically tunable OAM light source is a critical step in the realization of OAM modulation and multiplexing. By harnessing the properties of total momentum conservation, spin-orbit interaction, and optical non-Hermitian symmetry breaking, we demonstrate an OAM-tunable vortex microlaser, providing chiral light states of variable topological charges at a single telecommunication wavelength. The scheme of the non-Hermitian-controlled chiral light emission at room temperature can be further scaled up for simultaneous multivortex emissions in a flexible manner. Our work provides a route for the development of the next generation of multidimensional OAM-spin-wavelength division multiplexing technology., (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)

Miniaturization of implantable devices is an important challenge for future brain-computer interface applications, and in particular for achieving precise neuron stimulation. For stimulation that utilizes light, i.e., optogenetics, the light propagation behavior and interaction at the nanoscale with elements within the neuron is an important factor that needs to be considered when designing the device. This paper analyzes the effect of light behavior for a single neuron stimulation and focuses on the impact from different cell shapes. Based on the Mie scattering theory, the paper analyzes how the shape of the soma and the nucleus contributes to the focusing effect resulting in an intensity increase, which ensures that neurons can assist in transferring light through the tissue toward the target cells. At the same time, this intensity increase can in turn also stimulate neighboring cells leading to interference within the neural circuits. This paper also analyzes the ideal placements of the device with respect to the angle and position within the cortex that can enable axonal biophoton communications, which can contain light within the cell to avoid the interference.

By interconnecting nanomachines and forming nanonetworks, the capacities of single nanomachines are expected to be enhanced, as the ensuing information exchange will allow them to cooperate towards a common goal. Nowadays, systems normally use electromagnetic signals to encode, send and receive information, however, in a novel communication paradigm, molecular transceivers, channel models or protocols use molecules. This article presents the current developments in nanomachines along with their future architecture to better understand nanonetwork scenarios in biomedical applications. Furthermore, to highlight the communication needs between nanomachines, two applications for nanonetworks are also presented: i) a new networking paradigm, called the Internet of NanoThings, that allows nanoscale devices to interconnect with existing communication networks, and ii) Molecular Communication, where the propagation of chemical compounds like drug particles, carry out the information exchange., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Resiliency against eavesdropping and other security threats has become one of the key design considerations for communication systems. As wireless systems become ubiquitous, there is an increasing need for security protocols at all levels, including software (such as encryption), hardware (such as trusted platform modules) and the physical layer (such as wave-front engineering) 1-5 . With the inevitable shift to higher carrier frequencies, especially in the terahertz range (above 100 gigahertz), an important consideration is the decreased angular divergence (that is, the increased directionality) of transmitted signals, owing to the reduced effects of diffraction on waves with shorter wavelengths. In recent years, research on wireless devices 6-8 and systems 9-11 that operate at terahertz frequencies has ramped up markedly. These high-frequency, narrow-angle broadcasts present a more challenging environment for eavesdroppers compared to the wide-area broadcasts used at lower frequencies 12,13 . However, despite the widespread assumption of improved security for high-frequency wireless data links 14-16 , the possibility of terahertz eavesdropping has not yet been characterized. A few recent studies have considered the issue at lower frequencies 5,12,13,17,18 , but generally with the idea that the eavesdropper's antenna must be located within the broadcast sector of the transmitting antenna, leading to the conclusion that eavesdropping becomes essentially impossible when the transmitted signal has sufficiently high directionality 15 . Here we demonstrate that, contrary to this expectation, an eavesdropper can intercept signals in line-of-sight transmissions, even when they are transmitted at high frequencies with narrow beams. The eavesdropper's techniques are different from those for lower-frequency transmissions, as they involve placing an object in the path of the transmission to scatter radiation towards the eavesdropper. We also discuss one counter-measure for this eavesdropping technique, which involves characterizing the backscatter of the channel. We show that this counter-measure can be used to detect some, although not all, eavesdroppers. Our work highlights the importance of physical-layer security in terahertz wireless networks and the need for transceiver designs that incorporate new counter-measures.

In vivo wireless nanosensor networks (iWNSNs) are paving the way toward transformative healthcare solutions. These networks are expected to enable a plethora of applications, including drug-delivery, bio-sensing, and health monitoring. With the development of miniature plasmonic signal sources, antennas, and detectors, wireless communications among intrabody nanodevices will expectedly be enabled in the terahertz (THz) frequency band (0.1-10 THz). Several propagation models were recently developed to analyze and assess the feasibility of intra-body electromagnetic (EM) nanoscale communication. The emphasis of these works has mainly been on understanding the propagation of EM signals through biological media, with limited focus on the intra-body noise sources and their impact on the system performance. In this paper, a stochastic noise model for iWNSNs is presented in which the individual noise sources that impact intra-body systems operating in the THz frequency band are analyzed. The overall noise contributions are composed of three distinctive constituents, namely, Johnson-Nyquist noise, black-body noise, and Doppler-shift-induced noise. The probability distribution of each noise component is derived, and a comprehensive analytical approach is developed to obtain the total noise power-spectral density. The model is further validated via 2-D particle simulations as the active transport motion of particles is conveyed in the presented framework. The developed models serve as the starting point for a rigorous end-to-end channel model that enables the proper estimation of data rate, channel capacity, and other key parameters, which are all factors of the noise environment.

Exosomes are small extracellular vesicles released by cells for cell-cell communication. They play important roles in cancer development, metastasis, and drug resistance. Exosomal proteins have been demonstrated by many studies as promising biomarkers for cancer screening, diagnosis, and monitoring. Among many detection techniques, surface plasmon resonance (SPR) is a highly sensitive, label-free, and real-time optical detection method. Commercial prism-based wavelength/angular-modulated SPR sensors afford high sensitivity and resolution, but their large footprint and high cost limit their adaptability for clinical settings. Recently, a nanoplasmonic exosome (nPLEX) assay was developed to detect exosomal proteins for ovarian cancer diagnosis. However, comparing with conventional SPR biosensors, the broad applications of nanoplasmonic biosensors are limited by the difficult and expensive fabrication of nanostructures. We have developed an intensity-modulated, compact SPR biosensor (25 cm × 10 cm × 25 cm) which uses a conventional SPR sensing mechanism and does not require nanostructure fabrication. Calibration from glycerol showed that the compact SPR biosensor offered sensitivity of 9.258 × 10 3 %/RIU and resolution of 8.311 × 10 -6 RIU. We have demonstrated the feasibility of the compact SPR biosensor in lung cancer diagnosis using exosomal epidermal growth factor receptor (EGFR) and programmed death-ligand 1 (PD-L1) as biomarkers. It detected a higher level of exosomal EGFR from A549 nonsmall cell lung cancer (NSCLC) cells than BEAS-2B normal cells. With human serum samples, the compact SPR biosensor detected similar levels of exosomal EGFR in NSCLC patients and normal controls, and higher expression of exosomal PD-L1 in NSCLC patients than normal controls. The compact SPR biosensor showed higher detection sensitivity than ELISA and similar sensing accuracy as ELISA. It is a simple and user-friendly sensing platform, which may serve as an in vitro diagnostic test for cancer.

Stem cell-derived brain organoids replicate important stages of the prenatal human brain development and combined with the induced pluripotent stem cell (iPSC) technology offer an unprecedented model for investigating human neurological diseases including autism and microcephaly. We describe the history and birth of organoids and their application, focusing on cerebral organoids derived from embryonic stem cells and iPSCs. We discuss new insights into organoid-based model of schizophrenia and shed light on challenges and future applications of organoid-based disease model system. This review also suggests hitherto unrevealed potential applications of organoids in combining with new technologies such as nanophotonics/optogenomics for controlling brain development and atomic force microscopy for studying mechanical forces that shape the developing brain.

In recent years, numerous research efforts have been dedicated toward developing efficient implantable devices for brain stimulation. However, there are limitations and challenges with the current technologies. They include neuron population stimulation instead of single neuron level, the size, the biocompatibility, and the device lifetime reliability in the patient's brain. We have recently proposed the concept of wireless optogenetic nanonetworking devices (WiOptND) that could address the problem of long term deployment, and at the same time target single neuron stimulation utilizing ultrasonic as a mode for energy harvesting. In addition, a number of charging protocols are also proposed, in order to minimize the quantity of energy required for charging, while ensuring minimum number of neural spike misfirings. These protocols include the simple charge and fire, which requires the full knowledge of the raster plots of neuron firing patterns, and the predictive sliding detection window, and its variant Markov-chain based time-delay patterns, which minimizes the need for full knowledge of neural spiking patterns as well as number of ultrasound charging frequencies. Simulation results exhibit a drop for the stimulation ratio of ~ 25% and more stable trend in its efficiency ratio (standard deviation of ~0.5%) for the Markov-chain based time-delay patterns protocol compared with the baseline change and fire. The results show the feasibility of utilizing WiOptND for long-term implants in the brain, and a new direction toward precise stimulation of neurons in the cortical microcolumn of the brain cortex.

Wireless communication among implanted nano-biosensors will enable transformative smart health monitoring and diagnosis systems. The state of the art of nano-electronics and nano-photonics points to the terahertz (THz) band (0.1-10 THz) and optical frequency bands (infrared, 30-400 THz, and visible, 400-750 THz) as the frequency range for communication among nano-biosensors. Recently, several propagation models have been developed to study and assess the feasibility of intra-body electromagnetic (EM) nanoscale communication. These works have been mainly focused on understanding the propagation of EM signals through biological media, but do not capture the resulting photothermal effects and their impact both on the communication as well as on the body itself. In this paper, a novel thermal noise model for intra-body communication based on the diffusive heat flow theory is developed. In particular, an analytical framework is presented to illustrate how molecules in the human body absorb energy from EM fields and subsequently release this energy as heat to their immediate surroundings. As a result, a change in temperature is witnessed from which the molecular absorption noise can be computed. Such analysis has a dual benefit from a health as well as a communication perspective. For the medical community, the presented methodology allows the quantization of the temperature increase resulting from THz frequency absorption. For communication purposes, the complete understanding of the intra-body medium opens the door toward developing modulations suited for the capabilities of nano-machines and tailored to the peculiarities of the THz band channel as well as the optical window.

In the last few decades, the development of miniature biological sensors that can detect and measure different phenomena at the nanoscale has led to transformative disease diagnosis and treatment techniques. Among others, biofunctional Raman nanoparticles have been utilized in vitro and in vivo for multiplexed diagnosis and detection of different biological agents. However, existing solutions require the use of bulky lasers to excite the nanoparticles and similarly bulky and expensive spectrometers to measure the scattered Raman signals, which limit the practicality and applications of this nano-biosensing technique. In addition, due to the high path loss of the intra-body environment, the received signals are usually very weak, which hampers the accuracy of the measurements. In this paper, the concept of cooperative Raman spectrum reconstruction for real-time in vivo nano-biosensing is presented for the first time. The fundamental idea is to replace the single excitation and measurement points (i.e., the laser and the spectrometer, respectively) by a network of interconnected nano-devices that can simultaneously excite and measure nano-biosensing particles. More specifically, in the proposed system, a large number of nanosensors jointly and distributively collect the Raman response of nano-biofunctional nanoparticles (NBPs) travelling through the blood vessels. This paper presents a detailed description of the sensing system and, more importantly, proves its feasibility, by utilizing the accurate models of optical signal propagation in intra-body environment and low-complexity estimation algorithms. The numerical results show that with a certain density of NBPs, the reconstructed Raman spectrum can be recovered and utilized to accurately extract the targeting intra-body information.

Nanosized devices operating inside the human body open up new prospects in the healthcare domain. Invivo wireless nanosensor networks (iWNSNs) will result in a plethora of applications ranging from intrabody health-monitoring to drug-delivery systems. With the development of miniature plasmonic signal sources, antennas, and detectors, wireless communications among intrabody nanodevices will expectedly be enabled at both the terahertz band (0.1-10 THz) as well as optical frequencies (400-750 THz). This result motivates the analysis of the phenomena affecting the propagation of electromagnetic signals inside the human body. In this paper, a rigorous channel model for intrabody communication in iWNSNs is developed. The total path loss is computed by taking into account the combined effect of the spreading of the propagating wave, molecular absorption from human tissues, as well as scattering from both small and large body particles. The analytical results are validated by means of electromagnetic wave propagation simulations. Moreover, this paper provides the first framework necessitated for conducting link budget analysis between nanodevices operating within the human body. This analysis is performed by taking into account the transmitter power, medium path loss, and receiver sensitivity, where both the THz and photonic devices are considered. The overall attenuation model of intrabody THz and optical frequency propagation facilitates the accurate design and practical deployment of iWNSNs.

In vivo wireless nanosensor networks (iWNSNs) consist of nanosized communicating devices, which can operate inside the human body in real time. iWNSNs are at the basis of transformative healthcare techniques, ranging from intra-body health-monitoring systems to drug-delivery applications. Plasmonic nanoantennas are expected to enable the communication among nanosensors in the near infrared and optical transmission window. This result motivates the analysis of the phenomena affecting the propagation of such electromagnetic (EM) signals inside the human body. In this paper, a channel model for intra-body optical communication among nanosensors is developed. The total path loss is computed by taking into account the absorption from different types of molecules and the scattering by different types of cells. In particular, first, the impact of a single cell on the propagation of an optical wave is analytically obtained, by modeling a cell as a multi-layer sphere with complex permittivity. Then, the impact of having a large number of cells with different properties arranged in layered tissues is analyzed. The analytical channel model is validated by means of electromagnetic simulations and extensive numerical results are provided to understand the behavior of the intra-body optical wireless channel. The result shows that, at optical frequencies, the scattering loss introduced by cells is much larger than the absorption loss from the medium. This result motivates the utilization of the lower frequencies of the near-infrared window for communication in iWNSNs.

The scars produced by burns have serious consequences for the patient. The repercussions go further than the discomfort, pain and physical restrictions, going as far as causing significant psychological consequences which can restrict the personal and social relationships of those affected. From the accounts told by two burn victims, and the technical analysis carried out by psychologists and psychiatrists specialised in this field, we gain a better understanding of the situation of these patients, on the basis of which we propose a series of nursing interventions designed to improve the care given in the area of wound healing.

At times, the appearance of a pathological scar is a result of the scar process itself which can bring with it important physical and psychological complications for an affected person. The appearance of such a scar is more frequent in injuries which have followed a scar process caused as the consequence of a second operation and a disgraceful healing process. Preventive measures should be taken right at the start of treatment of the injury and continue during a set time after its initial closure. When, in spite of everything, a pathological scar appears, there are various materials and treatment techniques which provide different degrees of effectiveness.

A hepatodiaphragmatic interposition of the colon, known as Chilaiditi's sign, is usually discovered by chance during the study of another event, given that its presentation is normally asymptomatic. When this finding is accompanied by clinical symptoms, either intermittent or persistent, it is known as Chilaiditi syndrome. It may be associated with intestinal obstruction due to twisting. The association of Chilaiditi syndrome and transverse colon volvulus is exceptional. To date only three cases have been reported, all in adult males. Among the common predisposing factors were anatomical alterations of the intestine such as elongation of the colon and a history of prior abdominal surgery. The clinical symptoms were due to the intestinal obstruction. We present the first description in the paediatric population of an association of transverse colon volvulus and Chilaiditi syndrome whose predisposing factors, clinical symptoms and treatment differed from those reported in the non-paediatric cases published to date.