995 results on '"Jorgensen L."'
Search Results
2. Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool
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Goedegebuur, J., Abbel, D., Accassat, S., Achterberg, W.P., Akbari, A., Arfuch, V.M., Baddeley, E., Bax, J.J., Becker, D., Bergmeijer, B., Bertoletti, L., Blom, J.W., Calvetti, A., Cannegieter, S.C., Castro, L., Chavannes, N.H., Coma-Auli, N., Couffignal, C., Edwards, A., Edwards, M., Enggaard, H., Font, C., Gava, A., Geersing, G.J., Geijteman, E.C.T., Greenley, S., Gregory, C., Gussekloo, J., Hoffmann, I., Højen, A.A., van den Hout, W.B., Huisman, M.V., Jacobsen, S., Jagosh, J., Johnson, M.J., Jørgensen, L., Juffermans, C.C.M., Kempers, E.K., Konstantinides, S., Kroder, A.F., Kruip, M.J.H.A., Lafaie, L., Langendoen, J.W., Larsen, T.B., Lifford, K., van der Linden, Y.M., Mahé, I., Maiorana, L., Maraveyas, A., Martens, E.S.L., Mayeur, D., van Mens, T.E., Mohr, K., Mooijaart, S.P., Murtagh, F.E.M., Nelson, A., Nielsen, P.B., Ording, A.G., Ørskov, M., Pearson, M., Poenou, G., Portielje, J.E.A., Raczkiewicz, D., Rasmussen, K., Trinks-Roerdink, E., Schippers, I., Seddon, K., Sexton, K., Sivell, S., Skjøth, F., Søgaard, M., Szmit, S., Trompet, S., Vassal, P., Visser, C., van Vliet, L.M., Wilson, E., Klok, F.A., and Noble, S.I.R.
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- 2023
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3. Impact of early inoculation of probiotics to suckling piglets on postweaning diarrhoea – A challenge study with Enterotoxigenic E. Coli F18
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Hansen, L.H.B, Lauridsen, C., Nielsen, B., Jørgensen, L., and Canibe, N.
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- 2022
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4. Treatment Patterns, Socioeconomic Status and Clinical Burden in Mild COPD: A Swedish Real-World, Retrospective Cohort Study, the ARCTIC Study
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Larsson K, Lisspers K, Ställberg B, Johansson G, Gutzwiller FS, Mezzi K, Bjerregaard BK, Jorgensen L, Koo H, and Janson C
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chronic obstructive pulmonary disease ,socioeconomic status ,comorbidities ,co-medications ,annual income ,exacerbation ,sweden ,Diseases of the respiratory system ,RC705-779 - Abstract
Kjell Larsson,1 Karin Lisspers,2 Björn Ställberg,2 Gunnar Johansson,2 Florian S Gutzwiller,3 Karen Mezzi,3 Bine Kjoeller Bjerregaard,4 Leif Jorgensen,4 Hyewon Koo,5 Christer Janson6 1Integrative Toxicology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 2Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden; 3Novartis Pharma AG, Basel, Switzerland; 4IQVIA Solutions, Copenhagen, Denmark; 5IQVIA Solutions, Solna, Sweden; 6Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, SwedenCorrespondence: Kjell Larsson, Integrative Toxicology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SE-171 77, Sweden, Tel +467 0582 0763, Email kjell.larsson@ki.seBackground: Patients with mild chronic obstructive pulmonary disease (COPD) account for more than half of the total COPD population but are often undiagnosed and sparsely studied. This real-world, longitudinal study compared the socioeconomic burden, clinical characteristics and treatment patterns in patients with mild COPD and age- and gender-matched controls.Patients and methods: Our population included mild COPD patients (forced expiratory volume in one second ≥ 80% of predicted value) and reference controls from 52 Swedish primary care centres over 15 years (2000– 2014). We linked electronic medical record (EMR) data to Sweden’s National Health Registries. The outcomes analyzed were socioeconomic status including annual income from work, presence of comorbidities and the use of medications.Results: 844 patients with mild COPD were included in this study and matched with 844 reference controls. Compared with the reference controls, mild COPD patients had a significantly lower annual income from work (mean difference, men: 12,559€ and women: 7143€) and were significantly less likely to be married or employed. The presence of comorbidities, including cardiovascular disease, anxiety and depression (only women) was significantly higher in mild COPD patients. The use of medications, such as proton pump inhibitors, antidepressants, central painkillers and sleep medications, was significantly higher in the mild COPD group.Conclusion: Mild COPD presents a considerable socioeconomic and clinical burden compared with reference controls The findings suggest that COPD constitutes a condition that influences health status even in mild disease clearly demanding an increased need for early detection and treatment.Keywords: chronic obstructive pulmonary disease, socioeconomic status, comorbidities, co-medications, annual income, exacerbation, Sweden
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- 2022
5. Decreasing azole sensitivity of Z. tritici in Europe contributes to reduced and varying field efficacy
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Jørgensen, L. N., Matzen, N., Heick, T. M., Havis, N., Holdgate, S., Clark, B., Blake, J., Glazek, M., Korbas, M., Danielewicz, J., Maumene, C., Rodemann, B., Weigand, S., Kildea, S., Bataille, C., Brauna-Morževska, E., Gulbis, K., Ban, R., Berg, G., Semaskiene, R., and Stammler, G.
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- 2021
6. Changes in the abdominal wall after anterior, posterior, and combined component separation
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Daes, J., Oma, E., and Jorgensen, L. N.
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- 2022
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7. Visceral obesity is a predictor of surgical site occurrence and hernia recurrence after open abdominal wall reconstruction
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Baastrup, N. N., Jensen, K. K., Christensen, J. K., and Jorgensen, L. N.
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- 2022
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8. Open versus laparoscopic umbilical and epigastric hernia repair: nationwide data on short- and long-term outcomes
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Henriksen, N. A., Jorgensen, L. N., Friis-Andersen, H., and Helgstrand, F.
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- 2022
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9. Functional in vitro screening of probiotic strains for inoculation of piglets as a prophylactic measure towards Enterotoxigenic Escherichia coli infection
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Hansen, L.H.B., Nielsen, B., Boll, E.J., Skjøt-Rasmussen, L., Wellejus, A., Jørgensen, L., Lauridsen, C., and Canibe, N.
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- 2021
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10. CHATGPT, MD: A PILOT STUDY UTILIZING LARGE LANGUAGE MODELS TO WRITE MEDICAL ABSTRACTS
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Holland, A, primary, Lorenz, W, additional, Cavanaugh, J, additional, Ayuso, S, additional, Scarola, G, additional, Jorgensen, L, additional, Kercher, K, additional, Smart, N, additional, Fischer, J, additional, Janis, J, additional, and Heniford, B T, additional
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- 2024
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11. The Impact of Exacerbation Frequency on Clinical and Economic Outcomes in Swedish COPD Patients: The ARCTIC Study
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Larsson K, Janson C, Lisspers K, Ställberg B, Johansson G, Gutzwiller FS, Mezzi K, Bjerregaard BK, and Jorgensen L
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chronic obstructive pulmonary disease ,exacerbations ,mortality ,lung function ,healthcare cost ,sweden ,Diseases of the respiratory system ,RC705-779 - Abstract
Kjell Larsson,1 Christer Janson,2 Karin Lisspers,3 Björn Ställberg,3 Gunnar Johansson,3 Florian S Gutzwiller,4 Karen Mezzi,4 Bine Kjoeller Bjerregaard,5 Leif Jorgensen5 1Integrative Toxicology, The National Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden; 2Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; 3Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden; 4Novartis Pharma AG, Global Patient Access, Basel, Switzerland; 5IQVIA Solutions, Real World Evidence Solutions, Copenhagen, DenmarkCorrespondence: Kjell LarssonIntegrative Toxicology, The National Institute of Environmental Medicine, Karolinska Institute, Stockholm, SE-171 77, SwedenTel +467 0582 0763Email kjell.larsson@ki.sePurpose: The aim of this study was to assess the association between exacerbation frequency and clinical and economic outcomes in patients with COPD.Patients and Methods: Electronic medical record data linked to National Health Registries were collected from COPD patients at 52 Swedish primary care centers (2000– 2014). The outcomes analyzed were exacerbation rate, mortality, COPD treatments, lung function and healthcare costs during the follow-up period. Based on the exacerbation rate two years before index date, the patients were initially classified into three groups, either 0, 1 or ≥ 2 exacerbations per year. After the index date, the classification into exacerbation groups was updated each year based on the exacerbation rate during the last year of follow-up. A sensitivity analysis was conducted excluding patients with asthma diagnosis from the analysis.Results: In total 18,586 COPD patients were analyzed. A majority of the patients (60– 70%) who either have had no exacerbation or frequent exacerbations (≥ 2/year) during the pre-index period remained in their group (ie, with 0 or ≥ 2 annual exacerbations) during up to 11 years of follow-up. Compared with having no exacerbation, mortality was higher in patients having 1 (HR; 2.06 [1.93– 2.20]) and ≥ 2 (4.58 [4.33– 4.84]) exacerbations at any time during the follow-up. Lung function decline was more rapid in patients with frequent exacerbations and there was an almost linear relationship between exacerbations frequency and mortality. Total healthcare costs were higher in the frequent exacerbation group (≥ 2/year) than in patients with no or one exacerbation annually (p< 0.0001 for both). The results did not differ from the main analysis after exclusion of patients with a concurrent asthma diagnosis.Conclusion: In addition to faster lung function decline and increased mortality, frequent exacerbations in COPD patients imply a significant economic burden.Keywords: chronic obstructive pulmonary disease, exacerbations, mortality, lung function, healthcare cost, Sweden
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- 2021
12. Annihilation of low energy antiprotons in silicon
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Aghion, S., Ahlén, O., Belov, A. S., Bonomi, G., Bräunig, P., Bremer, J., Brusa, R. S., Burghart, G., Cabaret, L., Caccia, M., Canali, C., Caravita, R., Castelli, F., Cerchiari, G., Cialdi, S., Comparat, D., Consolati, G., Derking, J. H., Di Domizio, S., Di Noto, L., Doser, M., Dudarev, A., Ferragut, R., Fontana, A., Genova, P., Giammarchi, M., Gligorova, A., Gninenko, S. N., Haider, S., Harasimowicz, J., Huse, T., Jordan, E., Jørgensen, L. V., Kaltenbacher, T., Kellerbauer, A., Knecht, A., Krasnický, D., Lagomarsino, V., Magnani, A., Mariazzi, S., Matveev, V. A., Moia, F., Nebbia, G., Nédélec, P., Pacifico, N., Petrácek, V., Prelz, F., Prevedelli, M., Regenfus, C., Riccardi, C., Røhne, O., Rotondi, A., Sandaker, H., Sosa, A., Vasquez, M. A. Subieta, Špacek, M., Testera, G., Welsch, C. P., and Zavatarelli, S.
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Physics - Instrumentation and Detectors - Abstract
The goal of the AE$\mathrm{\bar{g}}$IS experiment at the Antiproton Decelerator (AD) at CERN, is to measure directly the Earth's gravitational acceleration on antimatter. To achieve this goal, the AE$\mathrm{\bar{g}}$IS collaboration will produce a pulsed, cold (100 mK) antihydrogen beam with a velocity of a few 100 m/s and measure the magnitude of the vertical deflection of the beam from a straight path. The final position of the falling antihydrogen will be detected by a position sensitive detector. This detector will consist of an active silicon part, where the annihilations take place, followed by an emulsion part. Together, they allow to achieve 1$%$ precision on the measurement of $\bar{g}$ with about 600 reconstructed and time tagged annihilations. We present here, to the best of our knowledge, the first direct measurement of antiproton annihilation in a segmented silicon sensor, the first step towards designing a position sensitive silicon detector for the AE$\mathrm{\bar{g}}$IS experiment. We also present a first comparison with Monte Carlo simulations (GEANT4) for antiproton energies below 5 MeV, Comment: 21 pages in total, 29 figures, 3 tables
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- 2013
13. Prospects for measuring the gravitational free-fall of antihydrogen with emulsion detectors
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AEgIS Collaboration, Aghion, S., Ahlén, O., Amsler, C., Ariga, A., Ariga, T., Belov, A. S., Bonomi, G., Bräunig, P., Bremer, J., Brusa, R. S., Cabaret, L., Canali, C., Caravita, R., Castelli, F., Cerchiari, G., Cialdi, S., Comparat, D., Consolati, G., Derking, J. H., Di Domizio, S., Di Noto, L., Doser, M., Dudarev, A., Ereditato, A., Ferragut, R., Fontana, A., Genova, P., Giammarchi, M., Gligorova, A., Gninenko, S. N., Haider, S., Harasimovicz, J., Hogan, S. D., Huse, T., Jordan, E., Jørgensen, L. V., Kaltenbacher, T., Kawada, J., Kellerbauer, A., Kimura, M., Knecht, A., Krasnický, D., Lagomarsino, V., Magnani, A., Mariazzi, S., Matveev, V. A., Moia, F., Nebbia, G., Nédélec, P., Oberthaler, M. K., Pacifico, N., Petrácek, V., Pistillo, C., Prelz, F., Prevedelli, M., Regenfus, C., Riccardi, C., Røhne, O., Rotondi, A., Sandaker, H., Scampoli, P., Sosa, A., Storey, J., Vasquez, M. A. Subieta, Spacek, M., Testera, G., Trezzi, D., Vaccarone, R., Welsch, C. P., and Zavatarelli, S.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The main goal of the AEgIS experiment at CERN is to test the weak equivalence principle for antimatter. AEgIS will measure the free-fall of an antihydrogen beam traversing a moir\'e deflectometer. The goal is to determine the gravitational acceleration g for antihydrogen with an initial relative accuracy of 1% by using an emulsion detector combined with a silicon micro-strip detector to measure the time of flight. Nuclear emulsions can measure the annihilation vertex of antihydrogen atoms with a precision of about 1 - 2 microns r.m.s. We present here results for emulsion detectors operated in vacuum using low energy antiprotons from the CERN antiproton decelerator. We compare with Monte Carlo simulations, and discuss the impact on the AEgIS project., Comment: 20 pages, 16 figures, 3 tables
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- 2013
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14. Antihydrogen formation dynamics in a multipolar neutral anti-atom trap
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Andresen, G. B., Bertsche, W., Bowe, P. D., Bray, C., Butler, E., Cesar, C. L., Chapman, S., Charlton, M., Fajans, J., Fujiwara, M. C., Gill, D. R., Hangst, J. S., Hardy, W. N., Hayano, R. S., Hayden, M. E., Humphries, A. J., Hydomako, R., Jørgensen, L. V., Kerrigan, S. J., Kurchaninov, L., Lambo, R., Madsen, N., Nolan, P., Olchanski, K., Olin, A., Povilus, A., Pusa, P., Robicheaux, F., Sarid, E., Nasr, S. Seif El, Silveira, D. M., Storey, J. W., Thompson, R. I., van der Werf, D. P., Wurtele, J. S., and Yamazaki, Y.
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High Energy Physics - Experiment ,Physics - Atomic Physics ,Physics - Plasma Physics - Abstract
Antihydrogen production in a neutral atom trap formed by an octupole-based magnetic field minimum is demonstrated using field-ionization of weakly bound anti-atoms. Using our unique annihilation imaging detector, we correlate antihydrogen detection by imaging and by field-ionization for the first time. We further establish how field-ionization causes radial redistribution of the antiprotons during antihydrogen formation and use this effect for the first simultaneous measurements of strongly and weakly bound antihydrogen atoms. Distinguishing between these provides critical information needed in the process of optimizing for trappable antihydrogen. These observations are of crucial importance to the ultimate goal of performing CPT tests involving antihydrogen, which likely depends upon trapping the anti-atom.
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- 2010
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15. Production of antihydrogen at reduced magnetic field for anti-atom trapping
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Andresen, G B, Bertsche, W, Boston, A, Bowe, P D, Cesar, C L, Chapman, S, Charlton, M, Chartier, M, Deutsch, A, Fajans, J, Fujiwara, M C, Funakoshi, R, Gill, D R, Gomberoff, K, Hangst, J S, Hayano, R S, Hydomako, R, Jenkins, M J, Jorgensen, L V, Kurchaninov, L, Madsen, N, Nolan, P, Olchanski, K, Olin, A, Page, R D, Povilus, A, Robicheaux, F, Sarid, E, Silveira, D M, Storey, J W, Thompson, R I, van derWerf, D P, Wurtele, J S, and Yamazaki, Y
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Nuclear Experiment - Abstract
We have demonstrated production of antihydrogen in a 1$,$T solenoidal magnetic field. This field strength is significantly smaller than that used in the first generation experiments ATHENA (3$,$T) and ATRAP (5$,$T). The motivation for using a smaller magnetic field is to facilitate trapping of antihydrogen atoms in a neutral atom trap surrounding the production region. We report the results of measurements with the ALPHA (Antihydrogen Laser PHysics Apparatus) device, which can capture and cool antiprotons at 3$,$T, and then mix the antiprotons with positrons at 1$,$T. We infer antihydrogen production from the time structure of antiproton annihilations during mixing, using mixing with heated positrons as the null experiment, as demonstrated in ATHENA. Implications for antihydrogen trapping are discussed.
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- 2008
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16. A novel antiproton radial diagnostic based on octupole induced ballistic loss
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Andresen, G. B., Bertsche, W., Bowe, P. D., Bray, C. C., Butler, E., Cesar, C. L., Chapman, S., Charlton, M., Fajans, J., Fujiwara, M. C., Funakoshi, R., Gill, D. R., Hangst, J. S., Hardy, W. N., Hayano, R. S., Hayden, M. E., Humphries, A. J., Hydomako, R., Jenkins, M. J., Jorgensen, L. V., Kurchaninov, L., Lambo, R., Madsen, N., Nolan, P., Olchanski, K., Olin, A., Page, R. D., Povilus, A., Pusa, P., Robicheaux, F., Sarid, E., Nasr, S. Seif El, Silveira, D. M., Storey, J. W., Thompson, R. I., van der Werf, D. P., Wurtele, J. S., and Yamazaki, Y.
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Physics - Atomic Physics ,Nuclear Experiment - Abstract
We report results from a novel diagnostic that probes the outer radial profile of trapped antiproton clouds. The diagnostic allows us to determine the profile by monitoring the time-history of antiproton losses that occur as an octupole field in the antiproton confinement region is increased. We show several examples of how this diagnostic helps us to understand the radial dynamics of antiprotons in normal and nested Penning-Malmberg traps. Better understanding of these dynamics may aid current attempts to trap antihydrogen atoms.
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- 2008
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17. Impact of COPD diagnosis timing on clinical and economic outcomes: the ARCTIC observational cohort study
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Larsson K, Janson C, Ställberg B, Lisspers K, Olsson P, Kostikas K, Gruenberger JB, Gutzwiller FS, Uhde M, Jorgensen L, and Johansson G
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Chronic obstructive pulmonary disease ,diagnosis ,Sweden ,exacerbations ,mortality ,Diseases of the respiratory system ,RC705-779 - Abstract
Kjell Larsson,1 Christer Janson,2 Björn Ställberg,3 Karin Lisspers,3 Petter Olsson,4 Konstantinos Kostikas,5 Jean-Bernard Gruenberger,5 Florian S Gutzwiller,5 Milica Uhde,6 Leif Jorgensen,7 Gunnar Johansson31Work Environment Toxicology, Karolinska Institutet, Stockholm, Sweden; 2Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; 3Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden; 4Novartis AB, Täby, Sweden; 5Novartis Pharma AG, Basel, Switzerland; 6IQVIA, Solna, Sweden; 7IQVIA, Copenhagen, DenmarkPurpose: Assess the clinical and economic consequences associated with an early versus late diagnosis in patients with COPD.Patients and methods: In a retrospective, observational cohort study, electronic medical record data (2000–2014) were collected from Swedish primary care patients with COPD. COPD indicators (pneumonia, other respiratory diseases, oral corticosteroids, antibiotics for respiratory infections, prescribed drugs for respiratory symptoms, lung function measurement) registered prior to diagnosis were applied to categorize patients into those receiving early (2 or less indicators) or late diagnosis (3 or more indicators registered >90 days preceding a COPD diagnosis). Outcome measures included annual rate of and time to first exacerbation, mortality risk, prevalence of comorbidities and health care utilization.Results: More patients with late diagnosis (n=8827) than with early diagnosis (n=3870) had a recent comorbid diagnosis of asthma (22.0% vs 3.9%; P
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- 2019
18. Compression of Antiproton Clouds for Antihydrogen Trapping
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Andresen, G. B., Bertsche, W., Bowe, P. D., Bray, C. C., Butler, E., Cesar, C. L., Chapman, S., Charlton, M., Fajans, J., Fujiwara, M. C., Funakoshi, R., Gill, D. R., Hangst, J. S., Hardy, W. N., Hayano, R. S., Hayden, M. E., Hydomako, R., Jenkins, M. J., Jorgensen, L. V., Kurchaninov, L., Lambo, R., Madsen, N., Nolan, P., Olchanski, K., Olin, A., Povilus, A., Pusa, P., Robicheaux, F., Sarid, E., Nasr, S. Seif El, Silveira, D. M., Storey, J. W., Thompson, R. I., van der Werf, D. P., Wurtele, J. S., and Yamazaki, Y.
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Nuclear Experiment - Abstract
Control of the radial profile of trapped antiproton clouds is critical to trapping antihydrogen. We report the first detailed measurements of the radial manipulation of antiproton clouds, including areal density compressions by factors as large as ten, by manipulating spatially overlapped electron plasmas. We show detailed measurements of the near-axis antiproton radial profile and its relation to that of the electron plasma.
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- 2008
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19. Particle Physics Aspects of Antihydrogen Studies with ALPHA at CERN
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ALPHA Collaboration, Fujiwara, M. C., Andresen, G. B., Bertsche, W., Bowe, P. D., Bray, C. C., Butler, E., Cesar, C. L., Chapman, S., Charlton, M., Fajans, J., Funakoshi, R., Gill, D. R., Hangst, J. S., Hardy, W. N., Hayano, R. S., Hayden, M. E., Humphries, A. J., Hydomako, R., Jenkins, M. J., Jorgensen, L. V., Kurchaninov, L., Lai, W., Lambo, R., Madsen, N., Nolan, P., Olchanski, K., Olin, A., Povilus, A., Pusa, P., Robicheaux, F., Sarid, E., Nasr, S. Seif El, Silveira, D. M., Storey, J. W., Thompson, R. I., van der Werf, D. P., Wasilenko, L., Wurtele, J. S., and Yamazaki, Y.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Nuclear Experiment ,Physics - Atomic Physics - Abstract
We discuss aspects of antihydrogen studies, that relate to particle physics ideas and techniques, within the context of the ALPHA experiment at CERN's Antiproton Decelerator facility. We review the fundamental physics motivations for antihydrogen studies, and their potential physics reach. We argue that initial spectroscopy measurements, once antihydrogen is trapped, could provide competitive tests of CPT, possibly probing physics at the Planck Scale. We discuss some of the particle detection techniques used in ALPHA. Preliminary results from commissioning studies of a partial system of the ALPHA Si vertex detector are presented, the results of which highlight the power of annihilation vertex detection capability in antihydrogen studies., Comment: Invited talk at Pbar08 - Workshop on Cold Antimatter Plasmas and Application to Fundamental Physics, Okinawa, Japan, 2008. 14 pages, 8 figures
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- 2008
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20. Production of Slow Protonium in Vacuum
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Zurlo, N., Amoretti, M., Amsler, C., Bonomi, G., Carraro, C., Cesar, C. L., Charlton, M., Doser, M., Fontana, A., Funakoshi, R., Genova, P., Hayano, R. S., Jorgensen, L. V., Kellerbauer, A., Lagomarsino, V., Landua, R., Rizzini, E. Lodi, Macri', M., Madsen, N., Manuzio, G., Mitchard, D., Montagna, P., Posada, L. G., Pruys, H., Regenfus, C., Rotondi, A., Testera, G., Van der Werf, D. P., Variola, A., Venturelli, L., and Yamazaki, Y.
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High Energy Physics - Experiment - Abstract
We describe how protonium, the quasi-stable antiproton-proton bound system, has been synthesized following the interaction of antiprotons with the molecular ion H$_2^+$ in a nested Penning trap environment. From a careful analysis of the spatial distributions of antiproton annihilation events in the ATHENA experiment, evidence is presented for protonium production with sub-eV kinetic energies in states around $n$ = 70, with low angular momenta. This work provides a new 2-body system for study using laser spectroscopic techniques., Comment: 9 pages with 5 figures and 1 table. Proceedings of the 4th International Conference on Trapped Charged Particles and Fundamental Physics (TCP 06), published in Hyperfine Interactions
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- 2008
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21. Evidence For The Production Of Slow Antiprotonic Hydrogen In Vacuum
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Zurlo, N., Amoretti, M., Amsler, C., Bonomi, G., Carraro, C., Cesar, C. L., Charlton, M., Doser, M., Fontana, A., Funakoshi, R., Genova, P., Hayano, R. S., Jorgensen, L. V., Kellerbauer, A., Lagomarsino, V., Landua, R., Rizzini, E. Lodi, Macrì, M., Madsen, N., Manuzio, G., Mitchard, D., Montagna, P., Posada, L. G., Pruys, H., Regenfus, C., Rotondi, A., Testera, G., Van der Werf, D. P., Variola, A., Venturelli, L., and Yamazaki, Y.
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High Energy Physics - Experiment - Abstract
We present evidence showing how antiprotonic hydrogen, the quasistable antiproton-proton (pbar-p) bound system, has been synthesized following the interaction of antiprotons with the hydrogen molecular ion (H2+) in a nested Penning trap environment. From a careful analysis of the spatial distributions of antiproton annihilation events, evidence is presented for antiprotonic hydrogen production with sub-eV kinetic energies in states around n=70, and with low angular momenta. The slow antiprotonic hydrogen may be studied using laser spectroscopic techniques., Comment: 5 pages with 4 figures. Published as Phys. Rev. Letters 97, 153401 (2006), in slightly different form
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- 2007
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22. Towards Antihydrogen Confinement with the ALPHA Antihydrogen Trap
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Fujiwara, M. C., Andresen, G., Bertsche, W., Boston, A., Bowe, P. D., Cesar, C. L., Chapman, S., Charlton, M., Chartier, M., Deutsch, A., Fajans, J., Funakoshi, R., Gill, D. R., Gomberoff, K., Hangst, J. S., Hardy, W. N., Hayano, R. S., Hydomako, R., Jenkins, M. J., Jorgensen, L. V., Kurchaninov, L., Madsen, N., Nolan, P., Olchanski, K., Olin, A., Page, R. D., Povilus, A., Robicheaux, F., Sarid, E., Silveira, D. M., Storey, J. W., Thompson, R. I., van der Werf, D. P., Wurtele, J. S., and Yamazaki, Y.
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Nuclear Experiment ,High Energy Physics - Experiment ,Physics - Atomic Physics ,Physics - Plasma Physics - Abstract
ALPHA is an international project that has recently begun experimentation at CERN's Antiproton Decelerator (AD) facility. The primary goal of ALPHA is stable trapping of cold antihydrogen atoms with the ultimate goal of precise spectroscopic comparisons with hydrogen. We discuss the status of the ALPHA project and the prospects for antihydrogen trapping., Comment: Invited talk at International Conference on Trapped Charged Particles and Fundamental Physics: TCP06, Parksville, BC, Canada, September 2006. To be published in Hyperfine Interactions
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- 2007
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23. Cold-Antimatter Physics
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ATHENA Collaboration, Amoretti, M., Amsler, C., Bonomi, G., Bowe, P. D., Canali, C., Carraro, C., Cesar, C. L., Charlton, M., Doser, M., Fontana, A., Fujiwara, M. C., Funakoshi, R., Genova, P., Hangst, J. S., Hayano, R. S., Johnson, I., Jorgensen, L. V., Kellerbauer, A., Lagomarsino, V., Landua, R., Rizzini, E. Lodi, Macri, M., Madsen, N., Manuzio, G., Mitchard, D., Montagna, P., Pruys, H., Regenfus, C., Rotondi, A., Testera, G., Variola, A., Venturelli, L., van der Werf, D. P., Yamazaki, Y., and Zurlo, N.
- Subjects
High Energy Physics - Experiment - Abstract
The CPT theorem and the Weak Equivalence Principle are foundational principles on which the standard description of the fundamental interactions is based. The validity of such basic principles should be tested using the largest possible sample of physical systems. Cold neutral antimatter (low-energy antihydrogen atoms) could be a tool for testing the CPT symmetry with high precision and for a direct measurement of the gravitational acceleration of antimatter. After several years of experimental efforts, the production of low-energy antihydrogen through the recombination of antiprotons and positrons is a well-established experimental reality. An overview of the ATHENA experiment at CERN will be given and the main experimental results on antihydrogen formation will be reviewed., Comment: Proceedings of the XLIII International Meeting on Nuclear Physics, Bormio (Italy), March 13-20 (2005). 10 pages, 4 figures, 1 table
- Published
- 2005
24. ATHENA -- First Production of Cold Antihydrogen and Beyond
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ATHENA Collaboration, Kellerbauer, A., Amoretti, M., Amsler, C., Bonomi, G., Bowe, P. D., Canali, C., Carraro, C., Cesar, C. L., Charlton, M., Doser, M., Fontana, A., Fujiwara, M. C., Funakoshi, R., Genova, P., Hangst, J. S., Hayano, R. S., Johnson, I., Jørgensen, L. V., Lagomarsino, V., Landua, R., Rizzini, E. Lodi, Macrí, M., Madsen, N., Manuzio, G., Mitchard, D., Montagna, P., Pruys, H., Regenfus, C., Rotondi, A., Testera, G., Variola, A., Venturelli, L., van der Werf, D. P., Yamazaki, Y., and Zurlo, N.
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High Energy Physics - Experiment - Abstract
Atomic systems of antiparticles are the laboratories of choice for tests of CPT symmetry with antimatter. The ATHENA experiment was the first to report the production of copious amounts of cold antihydrogen in 2002. This article reviews some of the insights that have since been gained concerning the antihydrogen production process as well as the external and internal properties of the produced anti-atoms. Furthermore, the implications of those results on future prospects of symmetry tests with antimatter are discussed., Comment: Proc. of the Third Meeting on CPT and Lorentz Symmetry, Bloomington (Indiana), USA, August 2004, edited by V. A. Kostelecky (World Scientific, Singapore). 10 pages, 5 figures, 1 table. Author affiliations corr
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- 2004
25. Production of Cold Antihydrogen with ATHENA for Fundamental Studies
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ATHENA Collaboration, Kellerbauer, A., Amoretti, M., Amsler, C., Bonomi, G., Bowe, P. D., Canali, C., Carraro, C., Cesar, C. L., Charlton, M., Doser, M., Fontana, A., Fujiwara, M. C., Funakoshi, R., Genova, P., Hangst, J. S., Hayano, R. S., Johnson, I., Jørgensen, L. V., Lagomarsino, V., Landua, R., Rizzini, E. Lodi, Macrí, M., Madsen, N., Manuzio, G., Mitchard, D., Montagna, P., Pruys, H., Regenfus, C., Rotondi, A., Testera, G., Variola, A., Venturelli, L., van der Werf, D. P., Yamazaki, Y., and Zurlo, N.
- Subjects
High Energy Physics - Experiment - Abstract
Since the beginning of operations of the CERN Antiproton Decelerator in July 2000, the successful deceleration, storage and manipulation of antiprotons has led to remarkable progress in the production of antimatter. The ATHENA Collaboration were the first to create and detect cold antihydrogen in 2002, and we can today produce large enough amounts of antiatoms to study their properties as well as the parameters that govern their production rate., Comment: Proceedings of the XXXIXth Rencontres de Moriond, 2004, Electroweak Interactions and Unified Theories, Ed. J. Tran Thanh Van. 8 pages, 7 figures, 1 table
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- 2004
26. Three Dimensional Annihilation Imaging of Antiprotons in a Penning Trap
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Fujiwara, M. C., Amoretti, M., Bonomi, G., Bouchta, A., Bowe, P. D., Carraro, C., Cesar, C. L., Charlton, M., Doser, M., Filippini, V., Fontana, A., Funakoshi, R., Genova, P., Hangst, J. S., Hayano, R. S., Jorgensen, L. V., Lagomarsino, V., Landuad, R., Lindelof, D., Rizzini, E. Lodi, Macri, M., Madsen, N., Marchesotti, M., Montagna, P., Pruys, H., Regenfus, C., Rielder, P., Rotondi, A., Testera, G., Variola, A., and van der Werf, D. P.
- Subjects
Physics - Plasma Physics ,High Energy Physics - Experiment ,Nuclear Experiment ,Physics - General Physics - Abstract
We demonstrate three-dimensional annihilation imaging of antiprotons trapped in a Penning trap. Exploiting unusual feature of antiparticles, we investigate a previously unexplored regime in particle transport; the proximity of the trap wall. Particle loss on the wall, the final step of radial transport, is observed to be highly non-uniform, both radially and azimuthally. These observations have considerable implications for the production and detection of antihydrogen atoms., Comment: Invited Talk at NNP03, Workshop on Non-Neutral Plasmas, 2003
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- 2004
- Full Text
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27. The First Cold Antihydrogen
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Fujiwara, M. C., Amoretti, M., Amsler, C., Bonomi, G., Bouchta, A., Bowe, P. D., Carraro, C., Cesar, C. L., Charlton, M., Doser, M., Filippini, V., Fontana, A., Funakoshi, R., Genova, P., Hangst, J. S., Hayano, R. S., Jorgensen, L. V., Lagomarsino, V., Landua, R., Lindelof, D., Rizzini, E. Lodi, Macri, M., Madsen, N., Marchesotti, M., Montagna, P., Pruys, H., Regenfus, C., Rielder, P., Rotondi, A., Testera, G., Variola, A., and van der Werf, D. P.
- Subjects
High Energy Physics - Experiment ,Nuclear Experiment - Abstract
Antihydrogen, the atomic bound state of an antiproton and a positron, was produced at low energy for the first time by the ATHENA experiment, marking an important first step for precision studies of atomic antimatter. This paper describes the first production and some subsequent developments., Comment: Invitated Talk at COOL03, International Workshop on Beam Cooling and Related Topics, to be published in NIM A
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- 2004
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- View/download PDF
28. Positron plasma diagnostics and temperature control for antihydrogen production
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ATHENA Collaboration, Amoretti, M., Amsler, C., Bonomi, G., Bouchta, A., Bowe, P. D., Carraro, C., Cesar, C. L., Charlton, M., Doser, M., Filippini, V., Fontana, A., Fujiwara, M. C., Funakoshi, R., Genova, P., Hangst, J. S., Hayano, R. S., Jorgensen, L. V., Lagomarsino, V., Landua, R., Lindelof, D., Rizzini, E. Lodi, Macri', M., Madsen, N., Manuzio, G., Montagna, P., Pruys, H., Regenfus, C., Rotondi, A., Testera, G., Variola, A., and van der Werf, D. P.
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Physics - Plasma Physics ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
Production of antihydrogen atoms by mixing antiprotons with a cold, confined, positron plasma depends critically on parameters such as the plasma density and temperature. We discuss non-destructive measurements, based on a novel, real-time analysis of excited, low-order plasma modes, that provide comprehensive characterization of the positron plasma in the ATHENA antihydrogen apparatus. The plasma length, radius, density, and total particle number are obtained. Measurement and control of plasma temperature variations, and the application to antihydrogen production experiments are discussed., Comment: 5 pages, 4 figures, to be published in Phys. Rev. Lett
- Published
- 2003
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29. First Production and Detection of Cold Antihydrogen Atoms
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Fujiwara, M. C., Amoretti, M., Amsler, C., Bonomi, G., Bouchta, A., Bowe, P., Carraro, C., Cesar, C. L., Charlton, M., Doser, M., Filippini, V., Fontana, A., Funakoshi, R., Genova, P., Hangst, J. S., Hayano, R. S., Jorgensen, L. V., Lagomarsino, V., Landua, R., Lindelof, D., Rizzini, E. Lodi, Marchesotti, M., Macri, M., Madsen, N., Montagna, P., Pruys, H., Regenfus, C., Rielder, P., Rotondi, A., Testera, G., Variola, A., and van der Werf, D. P.
- Subjects
High Energy Physics - Experiment ,Nuclear Experiment - Abstract
The ATHENA experiment recently produced the first atoms of cold antihydrogen. This paper gives a brief review of how this was achieved., Comment: Invited talk at Int. Conf. on Low Energy Antiprotons 2003 (LEAP03), to be published in NIM B
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- 2003
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- View/download PDF
30. Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS)): Part B
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Bittner, R., Bain, K., Bansal, V. K., Berrevoet, F., Bingener-Casey, J., Chen, D., Chen, J., Chowbey, P., Dietz, U. A., de Beaux, A., Ferzli, G., Fortelny, R., Hoffmann, H., Iskander, M., Ji, Z., Jorgensen, L. N., Khullar, R., Kirchhoff, P., Köckerling, F., Kukleta, J., LeBlanc, K., Li, J., Lomanto, D., Mayer, F., Meytes, V., Misra, M., Morales-Conde, S., Niebuhr, H., Radvinsky, D., Ramshaw, B., Ranev, D., Reinpold, W., Sharma, A., Schrittwieser, R., Stechemesser, B., Sutedja, B., Tang, J., Warren, J., Weyhe, D., Wiegering, A., Woeste, G., and Yao, Q.
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- 2019
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31. Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS))—Part A
- Author
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Bittner, R., Bain, K., Bansal, V. K., Berrevoet, F., Bingener-Casey, J., Chen, D., Chen, J., Chowbey, P., Dietz, U. A., de Beaux, A., Ferzli, G., Fortelny, R., Hoffmann, H., Iskander, M., Ji, Z., Jorgensen, L. N., Khullar, R., Kirchhoff, P., Köckerling, F., Kukleta, J., LeBlanc, K., Li, J., Lomanto, D., Mayer, F., Meytes, V., Misra, M., Morales-Conde, S., Niebuhr, H., Radvinsky, D., Ramshaw, B., Ranev, D., Reinpold, W., Sharma, A., Schrittwieser, R., Stechemesser, B., Sutedja, B., Tang, J., Warren, J., Weyhe, D., Wiegering, A., Woeste, G., and Yao, Q.
- Published
- 2019
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32. IMPLEMENTATION OF THE ALBERTA KIDNEY HEALTH CHECK PROTOCOL THROUGH CO-DESIGN WITH INDIGENOUS COMMUNITIES
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Philp, L., primary, Kirlin, N., additional, Jorgensen, L., additional, and Bello, A., additional
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- 2023
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33. Risk of mortality and recurrent cardiovascular events in patients with acute coronary syndromes on high intensity statin treatment
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Rockberg, J., Jørgensen, L., Taylor, B., Sobocki, P., and Johansson, G.
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- 2017
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34. Genetic variation in European blueberry (Vaccinium myrtillus L.) and the potential for exploitation in Scotland.
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McCallum, S, MacKenzie, K, Williamson, S, Jorgensen, L, Graham, J, and Montano, V
- Subjects
BILBERRY ,GENETIC variation ,MICROSATELLITE repeats ,GRASSLANDS - Abstract
The genetic variation of European blueberry species (known also as bilberry) has been the focus of considerable interest around the world, especially in relation to their commercial potential. Vaccinium myrtillus is a native European berry commonly found throughout central and north Europe. Little is currently known about the genetic variation of the European wild bilberry and its relation to their geographic distribution. Here we analysed the genetic diversity of Scottish wild bilberries (known locally as blaeberries) by means of simple sequence repeat (SSR) markers, and found significant genetic flow throughout the region, not directly correlated with the geographic distances among locations. Our results highlight a higher genetic diversity of bilberries growing in grasslands rather than woodlands, hinting to local adaptation. Future studies involving a more extended sampling are highly recommended to explore the current genetic variation of Scottish bilberries and their potential for commercial exploitation. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Correction to: Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS))—Part A
- Author
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Bittner, R., Bain, K., Bansal, V. K., Berrevoet, F., Bingener-Casey, J., Chen, D., Chen, J., Chowbey, P., Dietz, U. A., de Beaux, A., Ferzli, G., Fortelny, R., Hoffmann, H., Iskander, M., Ji, Z., Jorgensen, L. N., Khullar, R., Kirchhoff, P., Köckerling, F., Kukleta, J., LeBlanc, K., Li, J., Lomanto, D., Mayer, F., Meytes, V., Misra, M., Morales-Conde, S., Niebuhr, H., Radvinsky, D., Ramshaw, B., Ranev, D., Reinpold, W., Sharma, A., Schrittwieser, R., Stechemesser, B., Sutedja, B., Tang, J., Warren, J., Weyhe, D., Wiegering, A., Woeste, G., and Yao, Q.
- Published
- 2019
- Full Text
- View/download PDF
36. Clinical outcomes after parastomal hernia repair with a polyester monofilament composite mesh: a cohort study of 79 consecutive patients
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Oma, E., Pilsgaard, B., and Jorgensen, L. N.
- Published
- 2018
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37. Prevalence and predictors of distress in women taking part in surgical continuity of care for breast cancer: A cohort study
- Author
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Jørgensen, L., Laursen, B.S., Garne, J.P., Sherman, K.A., and Søgaard, M.
- Published
- 2016
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38. Comment to: Ventral hernia recurrence in women of childbearing age: a systematic review and meta-analysis. T. Nouh, F. S. Ali, K. J. Krause, I. Zaimi
- Author
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Oma, E., Jensen, K. K., and Jorgensen, L. N.
- Published
- 2021
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39. External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant data meta-analysis
- Author
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Allotey, J, Whittle, R, Snell, K, Smuk, M, Townsend, R, von Dadelszen, P, Heazell, A, Magee, L, Smith, G, Sandall, J, Thilaganathan, B, Zamora, J, Riley, R, Khalil, A, Thangaratinam, S, Coomarasamy, A, Kwong, A, Savitri, A, Salvesen, K, Bhattacharya, S, Uiterwaal, C, Staff, A, Andersen, L, Olive, E, Redman, C, Sletner, L, Daskalakis, G, Macleod, M, Abdollahain, M, Ramirez, J, Masse, J, Audibert, F, Magnus, P, Jenum, A, Baschat, A, Ohkuchi, A, Mcauliffe, F, West, J, Askie, L, Mone, F, Farrar, D, Zimmerman, P, Smits, L, Riddell, C, Kingdom, J, van de Post, J, Illanes, S, Holzman, C, van Kuijk, S, Carbillon, L, Villa, P, Eskild, A, Chappell, L, Prefumo, F, Velauthar, L, Seed, P, van Oostwaard, M, Verlohren, S, Poston, L, Ferrazzi, E, Vinter, C, Nagata, C, Brown, M, Vollebregt, K, Takeda, S, Langenveld, J, Widmer, M, Saito, S, Haavaldsen, C, Carroli, G, Olsen, J, Wolf, H, Zavaleta, N, Eisensee, I, Vergani, P, Lumbiganon, P, Makrides, M, Facchinetti, F, Sequeira, E, Gibson, R, Ferrazzani, S, Frusca, T, Norman, J, Figueiro, E, Lapaire, O, Laivuori, H, Lykke, J, Conde-Agudelo, A, Galindo, A, Mbah, A, Betran, A, Herraiz, I, Trogstad, L, Steegers, E, Salim, R, Huang, T, Adank, A, Zhang, J, Meschino, W, Browne, J, Allen, R, Costa, F, Klipstein-Grobusch Browne, K, Crowther, C, Jorgensen, J, Forest, J, Rumbold, A, Mol, B, Giguere, Y, Kenny, L, Ganzevoort, W, Odibo, A, Myers, J, Yeo, S, Goffinet, F, Mccowan, L, Pajkrt, E, Teede, H, Haddad, B, Dekker, G, Kleinrouweler, E, Lecarpentier, E, Roberts, C, Groen, H, Skrastad, R, Heinonen, S, Eero, K, Anggraini, D, Souka, A, Cecatti, J, Monterio, I, Pillalis, A, Souza, R, Hawkins, L, Gabbay-Benziv, R, Crovetto, F, Figuera, F, Jorgensen, L, Dodds, J, Patel, M, Aviram, A, Papageorghiou, A, Khan, K, Allotey J., Whittle R., Snell K. I. E., Smuk M., Townsend R., von Dadelszen P., Heazell A. E. P., Magee L., Smith G. C. S., Sandall J., Thilaganathan B., Zamora J., Riley R. D., Khalil A., Thangaratinam S., Coomarasamy A., Kwong A., Savitri A. I., Salvesen K. A., Bhattacharya S., Uiterwaal C. S. P. M., Staff A. C., Andersen L. B., Olive E. L., Redman C., Sletner L., Daskalakis G., Macleod M., Abdollahain M., Ramirez J. A., Masse J., Audibert F., Magnus P. M., Jenum A. K., Baschat A., Ohkuchi A., McAuliffe F. M., West J., Askie L. M., Mone F., Farrar D., Zimmerman P. A., Smits L. J. M., Riddell C., Kingdom J. C., van de Post J., Illanes S. E., Holzman C., van Kuijk S. M. J., Carbillon L., Villa P. M., Eskild A., Chappell L., Prefumo F., Velauthar L., Seed P., van Oostwaard M., Verlohren S., Poston L., Ferrazzi E., Vinter C. A., Nagata C., Brown M., Vollebregt K. C., Takeda S., Langenveld J., Widmer M., Saito S., Haavaldsen C., Carroli G., Olsen J., Wolf H., Zavaleta N., Eisensee I., Vergani P., Lumbiganon P., Makrides M., Facchinetti F., Sequeira E., Gibson R., Ferrazzani S., Frusca T., Norman J. E., Figueiro E. A., Lapaire O., Laivuori H., Lykke J. A., Conde-Agudelo A., Galindo A., Mbah A., Betran A. P., Herraiz I., Trogstad L., Smith G. G. S., Steegers E. A. P., Salim R., Huang T., Adank A., Zhang J., Meschino W. S., Browne J. L., Allen R. E., Costa F. D. S., Klipstein-Grobusch Browne K., Crowther C. A., Jorgensen J. S., Forest J. -C., Rumbold A. R., Mol B. W., Giguere Y., Kenny L. C., Ganzevoort W., Odibo A. O., Myers J., Yeo S. A., Goffinet F., McCowan L., Pajkrt E., Teede H. J., Haddad B. G., Dekker G., Kleinrouweler E. C., LeCarpentier E., Roberts C. T., Groen H., Skrastad R. B., Heinonen S., Eero K., Anggraini D., Souka A., Cecatti J. G., Monterio I., Pillalis A., Souza R., Hawkins L. A., Gabbay-Benziv R., Crovetto F., Figuera F., Jorgensen L., Dodds J., Patel M., Aviram A., Papageorghiou A., Khan K., Allotey, J, Whittle, R, Snell, K, Smuk, M, Townsend, R, von Dadelszen, P, Heazell, A, Magee, L, Smith, G, Sandall, J, Thilaganathan, B, Zamora, J, Riley, R, Khalil, A, Thangaratinam, S, Coomarasamy, A, Kwong, A, Savitri, A, Salvesen, K, Bhattacharya, S, Uiterwaal, C, Staff, A, Andersen, L, Olive, E, Redman, C, Sletner, L, Daskalakis, G, Macleod, M, Abdollahain, M, Ramirez, J, Masse, J, Audibert, F, Magnus, P, Jenum, A, Baschat, A, Ohkuchi, A, Mcauliffe, F, West, J, Askie, L, Mone, F, Farrar, D, Zimmerman, P, Smits, L, Riddell, C, Kingdom, J, van de Post, J, Illanes, S, Holzman, C, van Kuijk, S, Carbillon, L, Villa, P, Eskild, A, Chappell, L, Prefumo, F, Velauthar, L, Seed, P, van Oostwaard, M, Verlohren, S, Poston, L, Ferrazzi, E, Vinter, C, Nagata, C, Brown, M, Vollebregt, K, Takeda, S, Langenveld, J, Widmer, M, Saito, S, Haavaldsen, C, Carroli, G, Olsen, J, Wolf, H, Zavaleta, N, Eisensee, I, Vergani, P, Lumbiganon, P, Makrides, M, Facchinetti, F, Sequeira, E, Gibson, R, Ferrazzani, S, Frusca, T, Norman, J, Figueiro, E, Lapaire, O, Laivuori, H, Lykke, J, Conde-Agudelo, A, Galindo, A, Mbah, A, Betran, A, Herraiz, I, Trogstad, L, Steegers, E, Salim, R, Huang, T, Adank, A, Zhang, J, Meschino, W, Browne, J, Allen, R, Costa, F, Klipstein-Grobusch Browne, K, Crowther, C, Jorgensen, J, Forest, J, Rumbold, A, Mol, B, Giguere, Y, Kenny, L, Ganzevoort, W, Odibo, A, Myers, J, Yeo, S, Goffinet, F, Mccowan, L, Pajkrt, E, Teede, H, Haddad, B, Dekker, G, Kleinrouweler, E, Lecarpentier, E, Roberts, C, Groen, H, Skrastad, R, Heinonen, S, Eero, K, Anggraini, D, Souka, A, Cecatti, J, Monterio, I, Pillalis, A, Souza, R, Hawkins, L, Gabbay-Benziv, R, Crovetto, F, Figuera, F, Jorgensen, L, Dodds, J, Patel, M, Aviram, A, Papageorghiou, A, Khan, K, Allotey J., Whittle R., Snell K. I. E., Smuk M., Townsend R., von Dadelszen P., Heazell A. E. P., Magee L., Smith G. C. S., Sandall J., Thilaganathan B., Zamora J., Riley R. D., Khalil A., Thangaratinam S., Coomarasamy A., Kwong A., Savitri A. I., Salvesen K. A., Bhattacharya S., Uiterwaal C. S. P. M., Staff A. C., Andersen L. B., Olive E. L., Redman C., Sletner L., Daskalakis G., Macleod M., Abdollahain M., Ramirez J. A., Masse J., Audibert F., Magnus P. M., Jenum A. K., Baschat A., Ohkuchi A., McAuliffe F. M., West J., Askie L. M., Mone F., Farrar D., Zimmerman P. A., Smits L. J. M., Riddell C., Kingdom J. C., van de Post J., Illanes S. E., Holzman C., van Kuijk S. M. J., Carbillon L., Villa P. M., Eskild A., Chappell L., Prefumo F., Velauthar L., Seed P., van Oostwaard M., Verlohren S., Poston L., Ferrazzi E., Vinter C. A., Nagata C., Brown M., Vollebregt K. C., Takeda S., Langenveld J., Widmer M., Saito S., Haavaldsen C., Carroli G., Olsen J., Wolf H., Zavaleta N., Eisensee I., Vergani P., Lumbiganon P., Makrides M., Facchinetti F., Sequeira E., Gibson R., Ferrazzani S., Frusca T., Norman J. E., Figueiro E. A., Lapaire O., Laivuori H., Lykke J. A., Conde-Agudelo A., Galindo A., Mbah A., Betran A. P., Herraiz I., Trogstad L., Smith G. G. S., Steegers E. A. P., Salim R., Huang T., Adank A., Zhang J., Meschino W. S., Browne J. L., Allen R. E., Costa F. D. S., Klipstein-Grobusch Browne K., Crowther C. A., Jorgensen J. S., Forest J. -C., Rumbold A. R., Mol B. W., Giguere Y., Kenny L. C., Ganzevoort W., Odibo A. O., Myers J., Yeo S. A., Goffinet F., McCowan L., Pajkrt E., Teede H. J., Haddad B. G., Dekker G., Kleinrouweler E. C., LeCarpentier E., Roberts C. T., Groen H., Skrastad R. B., Heinonen S., Eero K., Anggraini D., Souka A., Cecatti J. G., Monterio I., Pillalis A., Souza R., Hawkins L. A., Gabbay-Benziv R., Crovetto F., Figuera F., Jorgensen L., Dodds J., Patel M., Aviram A., Papageorghiou A., and Khan K.
- Abstract
Objective: Stillbirth is a potentially preventable complication of pregnancy. Identifying women at high risk of stillbirth can guide decisions on the need for closer surveillance and timing of delivery in order to prevent fetal death. Prognostic models have been developed to predict the risk of stillbirth, but none has yet been validated externally. In this study, we externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis to assess their predictive performance. Methods: MEDLINE, EMBASE, DH-DATA and AMED databases were searched from inception to December 2020 to identify studies reporting stillbirth prediction models. Studies that developed or updated prediction models for stillbirth for use at any time during pregnancy were included. IPD from cohorts within the International Prediction of Pregnancy Complications (IPPIC) Network were used to validate externally the identified prediction models whose individual variables were available in the IPD. The risk of bias of the models and cohorts was assessed using the Prediction study Risk Of Bias ASsessment Tool (PROBAST). The discriminative performance of the models was evaluated using the C-statistic, and calibration was assessed using calibration plots, calibration slope and calibration-in-the-large. Performance measures were estimated separately in each cohort, as well as summarized across cohorts using random-effects meta-analysis. Clinical utility was assessed using net benefit. Results: Seventeen studies reporting the development of 40 prognostic models for stillbirth were identified. None of the models had been previously validated externally, and the full model equation was reported for only one-fifth (20%, 8/40) of the models. External validation was possible for three of these models, using IPD from 19 cohorts (491 201 pregnant women) within the IPPIC Network database. Based on evaluation of the model development studies, all three models had an overa
- Published
- 2022
40. Comment to: Hernia research in developing countries: are we looking for needles in haystacks? Insights from the Danish model
- Author
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Jorgensen, L. N. and Friis-Andersen, H.
- Published
- 2020
- Full Text
- View/download PDF
41. Genetic variation in European blueberry (Vaccinium myrtillusL.) and the potential for exploitation in Scotland
- Author
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McCallum, S, MacKenzie, K, Williamson, S, Jorgensen, L, Graham, J, and Montano, V
- Abstract
ABSTRACTThe genetic variation of European blueberry species (known also as bilberry) has been the focus of considerable interest around the world, especially in relation to their commercial potential. Vaccinium myrtillusis a native European berry commonly found throughout central and north Europe. Little is currently known about the genetic variation of the European wild bilberry and its relation to their geographic distribution. Here we analysed the genetic diversity of Scottish wild bilberries (known locally as blaeberries) by means of simple sequence repeat (SSR) markers, and found significant genetic flow throughout the region, not directly correlated with the geographic distances among locations. Our results highlight a higher genetic diversity of bilberries growing in grasslands rather than woodlands, hinting to local adaptation. Future studies involving a more extended sampling are highly recommended to explore the current genetic variation of Scottish bilberries and their potential for commercial exploitation.
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- 2024
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42. Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: Speech proficiency at 10 years of age
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Willadsen, E., Jorgensen, L. D., Alaluusua, S., Pedersen, N. H., Nielsen, J. B., Holtta, E., Hide, O., Hayden, C., Havstam, C., Lundeborg Hammarström, Inger, Davies, J., Boers, M., Andersen, H. S., Aukner, R., Morris, D. Jackson, Nielsen, S. F., Semb, G., Lohmander, A., Persson, C., Willadsen, E., Jorgensen, L. D., Alaluusua, S., Pedersen, N. H., Nielsen, J. B., Holtta, E., Hide, O., Hayden, C., Havstam, C., Lundeborg Hammarström, Inger, Davies, J., Boers, M., Andersen, H. S., Aukner, R., Morris, D. Jackson, Nielsen, S. F., Semb, G., Lohmander, A., and Persson, C.
- Abstract
Background & AimTo assess consonant proficiency and velopharyngeal function in 10-year-old children born with unilateral cleft lip and palate (UCLP) within the Scandcleft project. Methods & ProceduresThree parallel group, randomized, clinical trials were undertaken as an international multicentre study by nine cleft teams in five countries. Three different surgical protocols for primary palate repair (Arm B-Lip and soft palate closure at 3-4 months, hard palate closure at 36 months, Arm C-Lip closure at 3-4 months, hard and soft palate closure at 12 months, and Arm D-Lip closure at 3-4 months combined with a single-layer closure of the hard palate using a vomer flap, soft palate closure at 12 months) were tested against a common procedure (Arm A-Lip and soft palate closure at 3-4 months followed by hard palate closure at 12 months) in the total cohort of 431 children born with a non-syndromic UCLP. Speech audio and video recordings of 399 children were available and perceptually analysed. Percentage of consonants correct (PCC) from a naming test, an overall rating of velopharyngeal competence (VPC) (VPC-Rate), and a composite measure (VPC-Sum) were reported. Outcomes & ResultsThe mean levels of consonant proficiency (PCC score) in the trial arms were 86-92% and between 58% and 83% of the children had VPC (VPC-Sum). Only 50-73% of the participants had a consonant proficiency level with their peers. Girls performed better throughout. Long delay of the hard palate repair (Arm B) indicated lower PCC and simultaneous hard and soft palate closure higher (Arm C). However, the proportion of participants with primary VPC (not including velopharyngeal surgeries) was highest in Arm B (68%) and lowest in Arm C (47%). Conclusions & ImplicationsThe speech outcome in terms of PCC and VPC was low across the trials. The different protocols had their pros and cons and there is no obvious evidence to recommend any of the protocols as superior. Aspects other than primar, Funding Agencies|Landsforeningen Laebe-Ganespalte Denmar
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- 2023
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43. The experience of distress in relation to surgical treatment and care for breast cancer: An interview study
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Jørgensen, L., Garne, J.P., Søgaard, M., and Laursen, B.S.
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- 2015
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44. Development of a questionnaire encompassing indicators of distress: A tool for use with women in surgical continuity of care for breast cancer
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Jørgensen, L., Garne, J.P., Søgaard, M., and Laursen, B.S.
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- 2015
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45. PB0935 To Inform or not to Inform about Cancer-Associated Thrombosis: A Qualitative Study on Communication between Healthcare Professionals and Patients with Lung Cancer
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Berggreen, C., Hermann Schrader, J., Christensen, T., Maria Szejniuk, W., Søgaard, M., Jørgensen, L., and Højen, A.
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- 2023
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46. Colonic diverticulosis is associated with abdominal wall hernia
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Oma, E., Jorgensen, L. N., Meisner, S., and Henriksen, N. A.
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- 2017
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47. Primary ventral or groin hernia in pregnancy: a cohort study of 20,714 women
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Oma, E., Bay-Nielsen, M., Jensen, K. K., Jorgensen, L. N., Pinborg, A., and Bisgaard, T.
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- 2017
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48. The AEGIS experiment at CERN : Measuring the free fall of antihydrogen
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The AEGIS Collaboration, Kellerbauer, A., Allkofer, Y., Amsler, C., Belov, A. S., Bonomi, G., Bräunig, P., Bremer, J., Brusa, R. S., Burghart, G., Cabaret, L., Canali, C., Castelli, F., Chlouba, K., Cialdi, S., Comparat, D., Consolati, G., Dassa, L., Di Noto, L., Donzella, A., Doser, M., Dudarev, A., Eisel, T., Ferragut, R., Ferrari, G., Fontana, A., Genova, P., Giammarchi, M., Gligorova, A., Gninenko, S. N., Haider, S., Hansen, J. P., Haug, F., Hogan, S. D., Jørgensen, L. V., Kaltenbacher, T., Krasnický, D., Lagomarsino, V., Mariazzi, S., Matveev, V. A., Merkt, F., Moia, F., Nebbia, G., Nédélec, P., Niinikoski, T., Oberthaler, M. K., Perini, D., Petráček, V., Prelz, F., Prevedelli, M., Regenfus, C., Riccardi, C., Rochet, J., Røhne, O., Rotondi, A., Sacerdoti, M., Sandaker, H., Špaček, M., Storey, J., Testera, G., Tokareva, A., Trezzi, D., Vaccarone, R., Villa, F., Warring, U., Zavatarelli, S., Zenoni, A., Bühler, Paul, editor, Hartmann, Olaf, editor, Marton, Johann, editor, Suzuki, Ken, editor, Widmann, Eberhard, editor, and Zmeskal, Johann, editor
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- 2012
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49. Physical and bacterial controls on inorganic nutrients and dissolved organic carbon during a sea ice growth and decay experiment
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Zhou, J., Delille, B., Kaartokallio, H., Kattner, G., Kuosa, H., Tison, J.-L., Autio, R., Dieckmann, G.S., Evers, K.-U., Jørgensen, L., Kennedy, H., Kotovitch, M., Luhtanen, A.-M., Stedmon, C.A., and Thomas, D.N.
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- 2014
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50. The development of the gut microbiota in rainbow trout (Oncorhynchus mykiss) is affected by first feeding and diet type
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Ingerslev, H.-C., von Gersdorff Jørgensen, L., Lenz Strube, M., Larsen, N., Dalsgaard, I., Boye, M., and Madsen, L.
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- 2014
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