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5 results on '"Jordi Aragón"'

3. Photoredox Activation of Inert Alkyl Chlorides for the Reductive Cross‐Coupling with Aromatic Alkenes

Author

Jordi Aragón, Suyun Sun, David Pascual, Sebastian Jaworski, and Julio Lloret‐Fillol

Subjects
General Chemistry, General Medicine, Catalysis
Abstract

The inertness of chloroalkanes has precluded them as coupling partners for cross-coupling reactions. Herein we disclose a general strategy for the activation of inert alkyl chlorides through photoredox catalysis and their use as coupling partners with alkenes. The catalytic system is formed by [Ni(OTf)(Py

Published
2022

4. Light-Driven Reduction of Aromatic Olefins in Aqueous Media Catalysed by Aminopyridine Cobalt Complexes

Author

David Pascual, Julio Lloret-Fillol, Arnau Call, Jordi Aragón, Alicia Casitas, Carla Casadevall, and Irene Casademont-Reig

Subjects
chemistry.chemical_compound, Olefin fiber, Chemistry, Aryl, Photocatalysis, chemistry.chemical_element, Reactivity (chemistry), General Chemistry, Selectivity, Cobalt, Combinatorial chemistry, Catalysis, Artificial photosynthesis
Abstract

A catalytic system based on earth-abundant elements that efficiently hydrogenates aryl olefins using visible light as driving-force and H2O as the sole hydrogen atoms source is reported. The catalytic system involves a robust and well-defined aminopyridine cobalt complex and a heteroleptic Cu photoredox catalyst. The system shows the reduction of styrene in aqueous media with a remarkable selectivity (> 20000) versus water reduction (WR). Reactivity and mechanistic studies support the formation of a [Co-H] intermediate, which reacts as a hydrogen transfer agent (HAT). Synthetically useful deuterium-labelled compounds can be straightforwardly obtained by replacing H2O with D2O and using only catalysts based on earth-abundant elements. Moreover, the dual photocatalytic system and the photocatalytic conditions can be rationally designed to tune the selectivity for aryl olefin vs aryl ketone reduction; not only by changing the structural and electronic properties of the cobalt catalysts, but also by modifying the reduction properties of the light-harvesting system

Published
2021

5. The Power of High-Throughput Experimentation: General Topics and Enabling Technologies for Synthesis and Catalysis (Volume 1)

Author

Marion H. Emmert, Matthieu Jouffroy, David C. Leitch, Simon Berritt, Melodie Christensen, Magnus J. Johansson, Shane W. Krska, Stephen G. Newman, Jessica Sampson, Eric M. Simmons, Ying Wang, Neil A. Strotman, Iulia I. Strambeanu, Justin B. Diccianni, C. Liana Allen, Kelsey F. VanGelder, Courtney K. Maguire, Nessa Carson, Daniel A. DiRocco, Spencer D. Dreher, David C. Isom, Rosanne Isom, Michael Shevlin, Alexandra C. Sun, Corey R. J. Stephenson, Robert T. Kennedy, Carla Casadevall, Jordi Aragón, Santiago Cañellas, Miquel A. Pericàs, Julio Lloret-Fillol, Xisco Caldentey, Jonas Rein, Song Lin, Dipannita Kalyani, Dan Lehnherr, Noah P Tu, Brian J. Kotecki, Marion H. Emmert, Matthieu Jouffroy, David C. Leitch, Simon Berritt, Melodie Christensen, Magnus J. Johansson, Shane W. Krska, Stephen G. Newman, Jessica Sampson, Eric M. Simmons, Ying Wang, Neil A. Strotman, Iulia I. Strambeanu, Justin B. Diccianni, C. Liana Allen, Kelsey F. VanGelder, Courtney K. Maguire, Nessa Carson, Daniel A. DiRocco, Spencer D. Dreher, David C. Isom, Rosanne Isom, Michael Shevlin, Alexandra C. Sun, Corey R. J. Stephenson, Robert T. Kennedy, Carla Casadevall, Jordi Aragón, Santiago Cañellas, Miquel A. Pericàs, Julio Lloret-Fillol, Xisco Caldentey, Jonas Rein, Song Lin, Dipannita Kalyani, Dan Lehnherr, Noah P Tu, and Brian J. Kotecki

Subjects
Combinatorial chemistry, Pharmaceutical chemistry, High throughput screening (Drug development), Biopharmaceutics
Abstract

'High-throughput experimentation (HTE) is an emerging and powerful approach to problems in organic chemistry and homogeneous catalysis. This book is targeted at both experts and those new to the field who are seeking general perspectives and design principles for how to build and implement HTE capabilities. Specific examples of high-throughput experimental design and execution in the context of organic synthesis are included. Volume 1 covers general topics, including the history of HTE and its transition from highly specialized groups to more general adoption across industry and academia, along with the current state-of-the-art with respect to high-throughput technologies, including photo- and electrochemistry, nanoscale reactions, and others. Chapters are authored by practitioners in industry and academia, showcasing how a high-throughput mindset enables rapid optimization of existing chemistries and discovery of new reactivity.'--

Published
2022

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