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1. Lymph node metastases in paediatric and young adult patients with non-rhabdomyosarcoma soft tissue sarcoma (NRSTS): Findings from Childrens Oncology Group (COG) study ARST0332.

Author

He, Jiayi, Spunt, Sheri, Hayes-Jordan, Andrea, Kao, Simon, Parham, David, Million, Lynn, Weiss, Aaron, Barkauskas, Donald, and Alvarez, Elysia

Subjects
Lymph node metastases, Non-rhabdomyosarcoma soft tissue sarcoma (NRSTS), Paediatric, Prognostic factor, Adult, Child, Humans, Young Adult, Antineoplastic Combined Chemotherapy Protocols, Lymphatic Metastasis, Rhabdomyosarcoma, Sarcoma, Soft Tissue Neoplasms
Abstract

PURPOSE: The aim of this paper is to better define the clinical features and outcomes of young patients with non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) with regional and distant lymph node (LN) metastases treated in a standardised fashion, we analysed LN involvement in COG study ARST0332, which evaluated a risk-based treatment strategy for young patients with all stages of NRSTS. PATIENTS AND METHODS: Patients

Published
2023

2. Local Control For High-Grade Nonrhabdomyosarcoma Soft Tissue Sarcoma Assigned to Radiation Therapy on ARST0332: A Report From the Childrens Oncology Group

Author

Million, Lynn, Hayes-Jordan, Andrea, Chi, Yueh-Yun, Donaldson, Sarah S, Wolden, Suzanne, Morris, Carol, Terezakis, Stephanie, Laurie, Fran, Morano, Karen, Fitzgerald, TJ, Yock, Torunn I, Rodeberg, David A, Anderson, James R, Speights, Rose Anne, Black, Jennifer O, Coffin, Cheryl, McCarville, Mary Beth, Kao, Simon C, Hawkins, Douglas S, Spunt, Sheri L, and Randall, R Lor

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Clinical Research, Patient Safety, Pediatric, Clinical Trials and Supportive Activities, Pediatric Cancer, Cancer, 6.5 Radiotherapy and other non-invasive therapies, Evaluation of treatments and therapeutic interventions, Adolescent, Child, Child, Preschool, Female, Humans, Male, Neoplasm Grading, Research Design, Soft Tissue Neoplasms, Young Adult, Other Physical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Theoretical and computational chemistry, Medical and biological physics
Abstract

PurposeThe ARST0332 trial for pediatric and young adults with nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) used risk-based treatment including primary resection with lower-than-standard radiation doses to optimize local control (LC) while minimizing long-term toxicity in those requiring radiation therapy (RT). RT for high-grade NRSTS was based on extent of resection (R0: negative margins, R1: microscopic margins, R2/U: gross disease/unresectable); those with >5 cm tumors received chemotherapy (CT; ifosfamide/doxorubicin). This analysis evaluates LC for patients assigned to RT and prognostic factors associated with local recurrence (LR).Methods and materialsPatients aged 5 cm tumor (arm C); or neoadjuvant RT (45 Gy)/CT plus delayed surgery, CT, and postoperative boost to 10.8 Gy R0

Published
2021

3. Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial

Author

Weiss, Aaron R, Chen, Yen-Lin, Scharschmidt, Thomas J, Chi, Yueh-Yun, Tian, Jing, Black, Jennifer O, Davis, Jessica L, Fanburg-Smith, Julie C, Zambrano, Eduardo, Anderson, James, Arens, Robin, Binitie, Odion, Choy, Edwin, Davis, Justin W, Hayes-Jordan, Andrea, Kao, Simon C, Kayton, Mark L, Kessel, Sandy, Lim, Ruth, Meyer, William H, Million, Lynn, Okuno, Scott H, Ostrenga, Andrew, Parisi, Marguerite T, Pryma, Daniel A, Randall, R Lor, Rosen, Mark A, Schlapkohl, Mary, Shulkin, Barry L, Smith, Ethan A, Sorger, Joel I, Terezakis, Stephanie, Hawkins, Douglas S, Spunt, Sheri L, and Wang, Dian

Subjects
Pediatric, Pediatric Cancer, Cancer, Clinical Trials and Supportive Activities, Clinical Research, Adolescent, Adult, Antineoplastic Agents, Chemoradiotherapy, Chemotherapy, Adjuvant, Child, Child, Preschool, Female, Humans, Indazoles, Male, Middle Aged, Neoadjuvant Therapy, Pyrimidines, Radiotherapy, Adjuvant, Sarcoma, Soft Tissue Neoplasms, Sulfonamides, Young Adult, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundOutcomes for children and adults with advanced soft tissue sarcoma are poor with traditional therapy. We investigated whether the addition of pazopanib to preoperative chemoradiotherapy would improve pathological near complete response rate compared with chemoradiotherapy alone.MethodsIn this joint Children's Oncology Group and NRG Oncology multicentre, randomised, open-label, phase 2 trial, we enrolled eligible adults (aged ≥18 years) and children (aged between 2 and 16 years) performance status score of at least 70. Patients received ifosfamide (2·5 g/m2 per dose intravenously on days 1-3 with mesna) and doxorubicin (37·5 mg/m2 per dose intravenously on days 1-2) with 45 Gy preoperative radiotherapy, followed by surgical resection at week 13. Patients were randomly assigned (1:1) using a web-based system, in an unmasked manner, to receive oral pazopanib (if patients

Published
2020

5. A risk-based treatment strategy for non-rhabdomyosarcoma soft-tissue sarcomas in patients younger than 30 years (ARST0332): a Children's Oncology Group prospective study

Author

Spunt, Sheri L, Million, Lynn, Chi, Yueh-Yun, Anderson, James, Tian, Jing, Hibbitts, Emily, Coffin, Cheryl, McCarville, M Beth, Randall, R Lor, Parham, David M, Black, Jennifer O, Kao, Simon C, Hayes-Jordan, Andrea, Wolden, Suzanne, Laurie, Fran, Speights, Roseanne, Kawashima, Ellen, Skapek, Stephen X, Meyer, William, Pappo, Alberto S, and Hawkins, Douglas S

Subjects
Clinical Research, Patient Safety, Pediatric Cancer, Cancer, Digestive Diseases, Rare Diseases, Pediatric, 6.1 Pharmaceuticals, 6.5 Radiotherapy and other non-invasive therapies, Evaluation of treatments and therapeutic interventions, Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Chemoradiotherapy, Adjuvant, Child, Child, Preschool, Combined Modality Therapy, Doxorubicin, Female, Follow-Up Studies, Humans, Ifosfamide, Infant, Infant, Newborn, Male, Neoadjuvant Therapy, Prognosis, Prospective Studies, Risk Factors, Sarcoma, Surgical Procedures, Operative, Survival Rate, Young Adult, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundTumour grade, tumour size, resection potential, and extent of disease affect outcome in paediatric non-rhabdomyosarcoma soft-tissue sarcoma (NRSTS), but no risk stratification systems exist and the standard of care is poorly defined. We developed a risk stratification system from known prognostic factors and assessed it in the context of risk-adapted therapy for young patients with NRSTS.MethodsIn this prospective study, eligible patients enrolled in 159 hospitals in three countries were younger than 30 years, had a Lansky (patients ≤16 years) or Karnofsky (patients >16 years) performance status score of at least 50, and a new diagnosis of a WHO (2002 criteria) intermediate (rarely metastasising) or malignant soft-tissue tumour (apart from tumour types eligible for other Children's Oncology Group studies and tumours for which the therapy in this trial was deemed inappropriate), malignant peripheral nerve sheath tumour, non-metastatic and grossly resected dermatofibrosarcoma protuberans, undifferentiated embryonal sarcoma of the liver, or unclassified malignant soft-tissue sarcoma. Each patient was assigned to one of three risk groups and one of four treatment groups. Risk groups were: low (non-metastatic R0 or R1 low-grade, or ≤5 cm R1 high-grade tumour); intermediate (non-metastatic R0 or R1 >5 cm high-grade, or unresected tumour of any size or grade); or high (metastatic tumour). The treatment groups were surgery alone, radiotherapy (55·8 Gy), chemoradiotherapy (chemotherapy and 55·8 Gy radiotherapy), and neoadjuvant chemoradiotherapy (chemotherapy and 45 Gy radiotherapy, then surgery and radiotherapy boost based on margins with continued chemotherapy). Chemotherapy included six cycles of ifosfamide 3 g/m2 per dose intravenously on days 1-3 and five cycles of doxorubicin 37·5 mg/m2 per dose intravenously on days 1-2 every 3 weeks with sequence adjusted on the basis of timing of surgery or radiotherapy. The primary outcomes were event-free survival, overall survival, and the pattern of treatment failure. Analysis was done per protocol. This study has been completed and is registered with ClinicalTrials.gov, NCT00346164.FindingsBetween Feb 5, 2007, and Feb 10, 2012, 550 eligible patients were enrolled, of whom 21 were treated in the incorrect group and excluded from this analysis. 529 evaluable patients were included in the analysis: low-risk (n=222), intermediate-risk (n=227), high-risk (n=80); surgery alone (n=205), radiotherapy (n=17), chemoradiotherapy (n=111), and neoadjuvant chemoradiotherapy (n=196). At a median follow-up of 6·5 years (IQR 4·9-7·9), 5-year event-free survival and overall survival were: 88·9% (95% CI 84·0-93·8) and 96·2% (93·2-99·2) in the low-risk group; 65·0% (58·2-71·8) and 79·2% (73·4-85·0) in the intermediate-risk group; and 21·2% (11·4-31·1) and 35·5% (23·6-47·4) in the high-risk group, respectively. Risk group predicted event-free survival and overall survival (p

Published
2020

6. Clinical features and outcomes of young patients with epithelioid sarcoma: an analysis from the Children's Oncology Group and the European paediatric soft tissue Sarcoma Study Group prospective clinical trials

Author

Spunt, Sheri L, Francotte, Nadine, De Salvo, Gian Luca, Chi, Yueh-Yun, Zanetti, Ilaria, Hayes–Jordan, Andrea, Kao, Simon C, Orbach, Daniel, Brennan, Bernadette, Weiss, Aaron R, van Noesel, Max M, Million, Lynn, Alaggio, Rita, Parham, David M, Kelsey, Anna, Randall, R Lor, McCarville, M Beth, Bisogno, Gianni, Hawkins, Douglas S, and Ferrari, Andrea

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Pediatric, Clinical Trials and Supportive Activities, Clinical Research, Patient Safety, 6.5 Radiotherapy and other non-invasive therapies, 6.4 Surgery, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Child, Child, Preschool, Combined Modality Therapy, Disease-Free Survival, Doxorubicin, Female, Humans, Ifosfamide, Male, Neoadjuvant Therapy, Neoplasm Recurrence, Local, Prospective Studies, Retrospective Studies, Sarcoma, Soft Tissue Neoplasms, Young Adult, Epithelioid sarcoma, Paediatric, Soft tissue sarcoma, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundData on the clinical features, optimal treatment and outcomes of paediatric patients with epithelioid sarcoma (ES) are limited and mostly retrospective.MethodsA subset analysis of ES patients

Published
2019

10. The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma

Author

Lamhamedi-Cherradi, Salah-Eddine, Maitituoheti, Mayinuer, Menegaz, Brian A., Krishnan, Sandhya, Vetter, Amelia M., Camacho, Pamela, Wu, Chia-Chin, Beird, Hannah C., Porter, Robert W., Ingram, Davis R., Ramamoorthy, Vandhana, Mohiuddin, Sana, McCall, David, Truong, Danh D., Cuglievan, Branko, Futreal, P. Andrew, Velasco, Alejandra Ruiz, Anvar, Nazanin Esmaeili, Utama, Budi, Titus, Mark, Lazar, Alexander J., Wang, Wei-Lien, Rodriguez-Aguayo, Cristian, Ratan, Ravin, Livingston, J. Andrew, Rai, Kunal, MacLeod, A. Robert, Daw, Najat C., Hayes-Jordan, Andrea, and Ludwig, Joseph A.

Published
2022
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12. Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study

Author

Brooker, Joanne, Bragge, Peter, Rosenfeld, Jeffrey, Cooper, Jamie D., Helbok, Raimund, Beer, Ronny, Schoechl, Herbert, Rusnák, Martin, Schwendenwein, Elisabeth, Antoni, Anna, De Keyser, Véronique, Menovsky, Tomas, Van Praag, Dominique, Maas, Andrew I.R., Van der Steen, Gregory, Parizel, Paul M., Vande Vyvere, Thijs, Depreitere, Bart, Van Hecke, Wim, Verheyden, Jan, Misset, Benoit, Ledoux, Didier, Laureys, Steven, Ghuysen, Alexandre, Maréchal, Hugues, Dulière, Guy-Loup, Gao, Guoyi, Jiang, Ji-yao, Kondziella, Daniel, Fabricius, Martin, Schou, Rico Frederik, Blaabjerg, Morten, Rosenlund, Christina, Piippo-Karjalainen, Anna, Raj, Rahul, Pirinen, Matti, Ripatti, Samuli, Palotie, Aarno, Ylén, Peter, Posti, Jussi P., Tenovuo, Olli, Takala, Riikka, Payen, Jean-François, Vega, Emmanuel, Lejeune, Aurelie, Audibert, Gérard, Degos, Vincent, Benali, Habib, Galanaud, Damien, Perlbarg, Vincent, Puybasset, Louis, Azouvi, Philippe, Legrand, Valerie, Dahyot-Fizelier, Claire, Rossaint, Rolf, Coburn, Mark Steven, Kowark, Ana, Clusmann, Hans, Dreier, Jens, Wolf, Stefan, Vajkoczy, Peter, Maegele, Marc, Gratz, Johannes, Schäfer, Nadine, Lefering, Rolf, Covic, Amra, von Steinbüchel, Nicole, Schmidt, Silke, Bullinger, Monika, Younsi, Alexander, Unterberg, Andreas, Mattern, Julia, Sakowitz, Oliver, Sanchez-Porras, Renan, Perera, Natascha, Beauvais, Romuald, Sandor, Janos, Czeiter, Endre, Buki, Andras, Ezer, Erzsébet, Vámos, Zoltán, Melegh, Béla, Tamás, Viktória, Sorinola, Abayomi, Kovács, Noémi, Nyirádi, József, Amrein, Krisztina, Barzó, Pál, Gupta, Deepak, Levi, Leon, Rosenthal, Guy, Furmanov, Alex, Martino, Costanza, Beretta, Luigi, Calvi, Maria Rosa, Azzolini, Maria Luisa, Stocchetti, Nino, Calappi, Emiliana, Zoerle, Tommaso, Ortolano, Fabrizio, Carbonara, Marco, Caccioppola, Alessio, Citerio, Giuseppe, Vargiolu, Alessia, Chieregato, Arturo, Chevallard, Giorgio, Della Corte, Francesco, Grossi, Francesca, Rossi, Sandra, Persona, Paolo, Berardino, Maurizio, Cavallo, Simona, Rambadagalla, Malinka, Ziverte, Agate, Giga, Lelde, Valeinis, Egils, Vilcinis, Rimantas, Tamosuitis, Tomas, Rocka, Saulius, Ragauskas, Arminas, van der Naalt, Joukje, Jacobs, Bram, Steyerberg, Ewout W., Bartels, Ronald, den Boogert, Hugo, Kompanje, Erwin, Timmers, Marjolijn, Foks, Kelly, Haitsma, Iain, Volovici, Victor, van der Jagt, Mathieu, Haagsma, Juanita A., Mikolic, Ana, Lingsma, Hester, Velt, Kimberley, Huijben, Jilske, Voormolen, Daphne, Nieboer, Daan, Wiegers, Eveline, Sewalt, Charlie, Gravesteijn, Benjamin, Polinder, Suzanne, Tibboel, Dick, van Wijk, Roel, van Dijck, Jeroen T.J.M., van Essen, Thomas A., Peul, Wilco, Schoonman, Guus, Jones, Kelly, Feigin, Valery L., Te Ao, Braden, Theadom, Alice, Helseth, Eirik, Roe, Cecilie, Roise, Olav, Andelic, Nada, Frisvold, Shirin, Andreassen, Lasse, Anke, Audny, Vik, Anne, Skandsen, Toril, Ples, Horia, Tudora, Cristina Maria, Negru, Ancuta, Vulekovic, Peter, Đilvesi, Đula, Karan, Mladen, Golubovic, Jagoš, Rehorcíková, Veronika, Taylor, Mark Steven, Brazinova, Alexandra, Majdan, Marek, Sahuquillo, Juan, Radoi, Andreea, Carbayo Lozano, Guillermo, Pomposo, Inigo, Lagares, Alfonso, Gomez, Pedro A., Castaño-León, Ana M., Gagliardo, Pablo, Oresic, Matej, Bellander, Bo-Michael, Lanyon, Linda, George, Pradeep, Muraleedharan, Visakh, Nelson, David, Ackerlund, Cecilia, Koskinen, Lars-Owe, Sundström, Nina, Brorsson, Camilla, Belli, Antonio, Manara, Alex, Thomas, Matt, Czosnyka, Marek, Smielewski, Peter, Cabeleira, Manuel, Coles, Jonathan, Richardson, Sylvia, Zeiler, Frederick A., Stamatakis, Emmanuel, Williams, Guy, Menon, David, Ercole, Ari, Dixit, Abhishek, Newcombe, Virginia, Richter, Sophie, McFadyen, Charles, Hutchinson, Peter J., Kolias, Angelos G., Adams, Hadie, Correia, Marta, Rhodes, Jonathan, Stewart, William, McMahon, Catherine, Rueckert, Daniel, Glocker, Ben, Tolias, Christos, Dawes, Helen, Esser, Patrick, van Heugten, Caroline, Curry, Nicola, Stanworth, Simon, Lecky, Fiona, Otesile, Olubukola, Johnson, Faye, Dark, Paul, Jankowski, Stefan, Lightfoot, Roger, Wilson, Lindsay, Horton, Lindsay, Stevens, Robert, Rosand, Jonathan, Manley, Geoffrey, Jarrett, Mike, Brinck, Vibeke, Wang, Kevin K.W., Yang, Zhihui, Vespa, Paul M., Gruen, Russell L., Cameron, Peter, Donoghue, Emma, Gantner, Dashiell, Gruen, Russel, Murray, Lynette, Rosenfeld, Jeffrey V., Varma, Dinesh, Trapani, Tony, Vallance, Shirley, MacIsaac, Cristopher, Jordan, Andrea, Wiegers, Eveline Janine Anna, Lingsma, Hester Floor, Huijben, Jilske Antonia, Cooper, David James, Maas, Andrew Ian Ramsay, Menon, David Krishna, Moore, Elizabeth Madeleine, Dippel, Diederik Willem, and Steyerberg, Ewout Willem

Published
2021
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13. Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study

Author

Cardoso, Rafael, Guo, Feng, Heisser, Thomas, Hackl, Monika, Ihle, Petra, De Schutter, Harlinde, Van Damme, Nancy, Valerianova, Zdravka, Atanasov, Trajan, Májek, Ondřej, Mužík, Jan, Nilbert, Mef Christina, Tybjerg, Anne Julie, Innos, Kaire, Mägi, Margit, Malila, Nea, Bouvier, Anne-Marie, Bouvier, Véronique, Launoy, Guy, Woronoff, Anne-Sophie, Cariou, Mélanie, Robaszkiewicz, Michel, Delafosse, Patricia, Poncet, Florence, Katalinic, Alexander, Walsh, Paul M, Senore, Carlo, Rosso, Stefano, Vincerževskienė, Ieva, Lemmens, Valery E P P, Elferink, Marloes A G, Johannesen, Tom Børge, Kørner, Hartwig, Pfeffer, Frank, Bento, Maria José, Rodrigues, Jessica, Alves da Costa, Filipa, Miranda, Ana, Zadnik, Vesna, Žagar, Tina, Lopez de Munain Marques, Arantza, Marcos-Gragera, Rafael, Puigdemont, Montse, Galceran, Jaume, Carulla, Marià, Chirlaque, María-Dolores, Ballesta, Monica, Sundquist, Kristina, Sundquist, Jan, Weber, Marco, Jordan, Andrea, Herrmann, Christian, Mousavi, Mohsen, Ryzhov, Anton, Hoffmeister, Michael, and Brenner, Hermann

Published
2021
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14. The Evolving Management of Peritoneal Surface Malignancies

Author

Stewart, John H., IV, Blazer, Dan G., III, Calderon, Maria Jose Godoy, Carter, Taylor M., Eckhoff, Austin, Al Efishat, Mohammad A., Fernando, Deemantha G., Foster, Jason M., Hayes-Jordan, Andrea, Johnston, Fabian M., Lautz, Timothy B., Levine, Edward A., Maduekwe, Ugwuji N., Mangieri, Christopher W., Moaven, Omeed, Mogal, Harveshp, Shen, Perry, and Votanopoulos, Konstantinos I.

Published
2021
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21. Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif

Author

Breed, Matthew W, Elser, Samra E, Torben, Workineh, Jordan, Andrea PO, Aye, Pyone P, Midkiff, Cecily, Schiro, Faith, Sugimoto, Chie, Alvarez-Hernandez, Xavier, Blair, Robert V, Somasunderam, Anoma, Utay, Netanya S, Kuroda, Marcelo J, Pahar, Bapi, Wiseman, Roger W, O'Connor, David H, LaBranche, Celia C, Montefiori, David C, Marsh, Mark, Li, Yuan, Piatak, Michael, Lifson, Jeffrey D, Keele, Brandon F, Fultz, Patricia N, Lackner, Andrew A, and Hoxie, James A

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Vaccine Related, Immunization, HIV/AIDS, Infectious Diseases, Aetiology, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Amino Acid Motifs, Animals, CD4-Positive T-Lymphocytes, Disease Progression, Female, Gene Expression, Immunity, Mucosal, Intestines, Macaca mulatta, Macaca nemestrina, Male, Molecular Sequence Data, Mucous Membrane, Protein Sorting Signals, Protein Structure, Tertiary, Protein Transport, Sequence Deletion, Simian Acquired Immunodeficiency Syndrome, Simian Immunodeficiency Virus, Species Specificity, Viral Envelope Proteins, Viral Load, Viremia, Virus Replication, Simian immunodeficiency virus, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology, Agricultural, veterinary and food sciences, Biological sciences, Biomedical and clinical sciences
Abstract

UnlabelledDeletion of Gly-720 and Tyr-721 from a highly conserved GYxxØ trafficking signal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus termed ΔGY, leads to a striking perturbation in pathogenesis in rhesus macaques (Macaca mulatta). Infected macaques develop immune activation and progress to AIDS, but with only limited and transient infection of intestinal CD4(+) T cells and an absence of microbial translocation. Here we evaluated ΔGY in pig-tailed macaques (Macaca nemestrina), a species in which SIVmac239 infection typically leads to increased immune activation and more rapid progression to AIDS than in rhesus macaques. In pig-tailed macaques, ΔGY also replicated acutely to high peak plasma RNA levels identical to those for SIVmac239 and caused only transient infection of CD4(+) T cells in the gut lamina propria and no microbial translocation. However, in marked contrast to rhesus macaques, 19 of 21 pig-tailed macaques controlled ΔGY replication with plasma viral loads of

Published
2015

23. Clinical features and outcomes of young patients with epithelioid sarcoma: an analysis from the Children's Oncology Group and the European paediatric soft tissue Sarcoma Study Group prospective clinical trials

Author

Spunt, Sheri L., Francotte, Nadine, De Salvo, Gian Luca, Chi, Yueh-Yun, Zanetti, Ilaria, Hayes–Jordan, Andrea, Kao, Simon C., Orbach, Daniel, Brennan, Bernadette, Weiss, Aaron R., van Noesel, Max M., Million, Lynn, Alaggio, Rita, Parham, David M., Kelsey, Anna, Randall, R. Lor, McCarville, M. Beth, Bisogno, Gianni, Hawkins, Douglas S., and Ferrari, Andrea

Published
2019
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31. A Call to Action: Black/African American Women Surgeon Scientists, Where are They?

Author

Berry, Cherisse, Khabele, Dineo, Johnson-Mann, Crystal, Henry-Tillman, Ronda, Joseph, Kathie-Ann, Turner, Patricia, Pugh, Carla, Fayanju, Oluwadamilola M., Backhus, Leah, Sweeting, Raeshell, Newman, Erika A., Oseni, Tawakalitu, Hasson, Rian M., White, Cassandra, Cobb, Adrienne, Johnston, Fabian M., Stallion, Anthony, Karpeh, Martin, Nwariaku, Fiemu, Rodriguez, Luz Maria, and Jordan, Andrea Hayes

Published
2020
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32. A Single Amino Acid Mutation in the Envelope Cytoplasmic Tail Restores the Ability of an Attenuated Simian Immunodeficiency Virus Mutant To Deplete Mucosal CD4+ T Cells

Author

Breed, Matthew W, Jordan, Andrea PO, Aye, Pyone P, Sugimoto, Chie, Alvarez, Xavier, Kuroda, Marcelo J, Pahar, Bapi, Keele, Brandon F, Hoxie, James A, and Lackner, Andrew A

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Amino Acid Motifs, Animals, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Gene Products, env, Macaca, Male, Mucous Membrane, Mutation, Missense, Simian Acquired Immunodeficiency Syndrome, Simian Immunodeficiency Virus, Simian immunodeficiency virus, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology, Agricultural, veterinary and food sciences, Biological sciences, Biomedical and clinical sciences
Abstract

Disruption of the conserved motif GYxxØ in the simian immunodeficiency virus (SIV) SIVmac239 envelope (Env) cytoplasmic tail resulted in a virus (ΔGY) that exhibited a high plasma peak but uniquely failed to acutely deplete mucosal CD4(+) T cells. Here, we show that ΔGY containing a flanking S727P mutation that was acquired in ΔGY-infected macaques reacquired the ability to rapidly deplete CD4(+) T cells in lamina propria. This suggests that the GYxxØ motif and S727P each contribute to SIV's targeting to mucosal tissues.

Published
2013

34. Morphoproteomic Profiling of the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Desmoplastic Small Round Cell Tumor (EWS/WT1), Ewing’s Sarcoma (EWS/FLI1) and Wilms’ Tumor(WT1)

Author

Subbiah, Vivek, Brown, Robert E, Jiang, Yunyun, Buryanek, Jamie, Hayes-Jordan, Andrea, Kurzrock, Razelle, and Anderson, Pete M

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Pediatric Research Initiative, Pediatric, Rare Diseases, Cancer, Clinical Research, Adolescent, Adult, Desmoplastic Small Round Cell Tumor, Female, Humans, Immunohistochemistry, Male, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Multiprotein Complexes, Oncogene Proteins, Fusion, Proteomics, Proto-Oncogene Protein c-fli-1, RNA-Binding Protein EWS, Sarcoma, Ewing, Signal Transduction, Somatomedins, TOR Serine-Threonine Kinases, WT1 Proteins, Wilms Tumor, Young Adult, General Science & Technology
Abstract

BackgroundDesmoplastic small round cell tumor (DSRCT) is a rare sarcoma in adolescents and young adults. The hallmark of this disease is a EWS-WT1 translocation resulting from apposition of the Ewing's sarcoma (EWS) gene with the Wilms' tumor (WT1) gene. We performed morphoproteomic profiling of DSRCT (EWS-WT1), Ewing's sarcoma (EWS-FLI1) and Wilms' tumor (WT1) to better understand the signaling pathways for selecting future targeted therapies.MethodologyThis pilot study assessed patients with DSRCT, Wilms' tumor and Ewing's sarcoma. Morphoproteomics and immunohistochemical probes were applied to detect: p-mTOR (Ser2448); p-Akt (Ser473); p-ERK1/2 (Thr202/Tyr204); p-STAT3 (Tyr 705); and cell cycle-related analytes along with their negative controls.Principal findingsIn DSRCT the PI3K/Akt/mTOR pathway is constitutively activated by p-Akt (Ser 473) expression in the nuclear compartment of the tumor cells and p-mTOR phosphorylated on Ser 2448, suggesting mTORC2 (rictor+mTOR) as the dominant form. Ewing's sarcoma had upregulated p-Akt and p-mTOR, predominantly mTORC2. In Wilm's tumor, the mTOR pathway is also activated with most tumor cells moderately expressing p-mTOR (Ser 2448) in plasmalemmal and cytoplasmic compartments. This coincides with the constitutive activation of one of the downstream effectors of the mTORC1 signaling pathway, namely p-p70S6K (Thr 389). There was constitutive activation of the Ras/Raf/ERK pathway p-ERK 1/2 (Thr202/Tyr204) expression in the Wilms tumor and metastatic Ewing's sarcoma, but not in the DSRCT.ConclusionMORPHOPROTEOMIC TUMOR ANALYSES REVEALED CONSTITUTIVE ACTIVATION OF THE MTOR PATHWAY AS EVIDENCED BY: (a) expression of phosphorylated (p)-mTOR, p-p70S6K; (b) mTORC 2 in EWS and DSRCT; (c) ERK signaling was seen in the advanced setting indicating these as resistance pathways to IGF1R related therapies. This is the first morphoproteomic study of such pathways in these rare malignancies and may have potential therapeutic implications. Further study using morphoproteomic assessments of these tumors are warranted.

Published
2013

37. The Role of Race and Gender in the Career Experiences of Black/African American Academic Surgeons: A Survey of the Society of Black Academic Surgeons and a Call to Action

Author

Crown, Angelena, Berry, Cherisse, Khabele, Dineo, Fayanju, Oluwadamilola M., Cobb, Adrienne, Backhus, Leah, Smith, Randi N., Sweeting, Raeshell, Hasson, Rian M., Johnson-Mann, Crystal, Oseni, Tawakalitu, Newman, Erika A., Turner, Patricia, Karpeh, Martin, Pugh, Carla, Jordan, Andrea Hayes, Henry-Tillman, Ronda, and Joseph, Kathie-Ann

Published
2021
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44. It's Personal

Author

Jordan, Andrea

Subjects
Toiletries industry, Skin, Skin care products
Abstract

Digital devices practically rule our lives, so it's no surprise that skin care's latest trend is also tech-led. The future of your glow has arrived, and the best ingredient is [...]

Published
2021

49. Engaging Students in Physical Chemistry

Author

Craig M. Teague, David E. Gardner, David E. Gardner, Benjamin J. McFarland, Matthew C. Zwier, Craig M. Teague, Truman H. Jordan, Andrea N. Giordano, Michael Walzak, Kristina M. Lantzky, Molly B. Wilker, Elaine M. Marzluff, Mary A. Crawford, Jodye I. Selco, Ray C. Dudek, Courtney Stanford, Alena Moon

Published
2018

Catalog

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