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5. High-dose intravenous immunoglobulin versus albumin 4% in paediatric toxic shock syndrome: a randomised controlled feasibility study.

Author

Portefaix, Aurélie, Dhelens, Carole, Recher, Morgan, Cour-Andlauer, Fleur, Naudin, Jérôme, Mortamet, Guillaume, Joram, Nicolas, Tissières, Pierre, Ginhoux, Tiphanie, Kassai, Behrouz, Boutitie, Florent, Maucort-Boulch, Delphine, and Javouhey, Etienne

Subjects
TOXIC shock syndrome, MULTISYSTEM inflammatory syndrome in children, INTRAVENOUS immunoglobulins, SOFT tissue infections, BODY mass index, MEDICAL personnel
Published
2024
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15. Determining Optimal Mean Arterial Blood Pressure Based on Cerebral Autoregulation in Children after Cardiac Surgery

Author

Tabone, Laurence, primary, El-Tannoury, Jihad, additional, Levy, Michael, additional, Sauthier, Michael, additional, Joram, Nicolas, additional, Du Pont-Thibodeau, Geneviève, additional, Bourgoin, Pierre, additional, Al-Omar, Sally, additional, Poirier, Nancy, additional, Emeriaud, Guillaume, additional, and Thibault, Céline, additional

Published
2023
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18. Effectiveness of intraoperative use of dexmedetomidine in reducing the incidence of tachyarrhythmia after congenital cardiac surgery in neonates and infants: a doubly robust method estimation analysis

Author

Bourgoin, Pierre, primary, Jegard, Julien, additional, Joram, Nicolas, additional, Fox, Sylvain, additional, Biard, Marc, additional, Fernandez, Modesto, additional, Baruteau, Alban Elouen, additional, Dejoie, Thomas, additional, Ferdynus, Cyril, additional, and Chenouard, Alexis, additional

Published
2023
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19. Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions

Author

Karam, Oliver, Demaret, Pierre, Duhamel, Alain, Shefler, Alison, Spinella, Philip C., Stanworth, Simon J., Tucci, Marisa, Leteurtre, Stéphane, Butt, Warwick, Delzoppo, Carmel, Bain, Kym, Erickson, Simon, Smalley, Nathan, Dorofaeff, Tavey, Long, Debbie, Wiseman, Greg, Clénent de Cléty, Stéphan, Berghe, Caroline, de Jaeger, Annick, Demaret, Pierre, Trippaerts, Marc, Willems, Ariane, Rooze, Shancy, De Dooy, Jozef, Gilfoyle, Elaine, Wohlgemuth, Lynette, Tucci, Marisa, Dumitrascu, Mariana, Withington, Davinia, Hickey, Julia, Choong, Karen, Sanders, Lois, Morrison, Gavin, Tijssen, Janice, Wensley, David, Krahn, Gordon, Dugas, Marc-Andre, Gosselin, Louise, Santschi, Miriam, Von Dessauer, Bettina, Ordenes, Nadia, Afshari, Arash, Andersen, Lasse Hoegh, Nilsson, Jens Christian, Johansen, Mathias, Baek Jensen, Anne-Mette, Campos Mino, Santiago, Grunauer, Michelle, Joram, Nicolas, Roullet-Renoleau, Nicolas, Javouhey, Etienne, Cour-Andlauer, Fleur, Portefaix, Aurélie, Brissaud, Olivier, Guichoux, Julie, Payen, Valérie, Léger, Pierre-Louis, Afanetti, Mickael, Mortamet, Guillaume, Maria, Matthieu, Breining, Audrey, Tissieres, Pierre, Dorkenoo, Aimée, Deho, Anna, Steinherr, Harry, Nikolaou, Filippia, Camporesi, Anna, Mario, Federica, Kawasaki, Tatsuya, Miura, Shinya, Beca, John, Rea, Miriam, Sherring, Claire, Bushell, Tracey, Bentsen, Gunnar, Dinis, Alexandra, Pereira, Gabriela, Vieira, Marisa, Moniz, Marta, Alshehri, Saleh, Alasnag, Manal, Pisarcikova, Maria, Jordan, Iolanda, Balcells, Joan, Perez-Ferrer, Antonio, de Vicente Sánchez, Jesús, Vazquez Moyano, Marta, Morales Martinez, Antonio, Lopez-Herce, Jesus, Solana, Maria Jose, Flores González, Jose Carlos, Alonso, Maria Teresa, Nieto Faza, Manuel, Perez, Marie-Hélène, Amiet, Vivianne, Doell, Carsten, Bordessoule, Alice, Cochius-den Otter, Suzan, Kapitein, Berber, Kneyber, Martin, Brierley, Joe, Rea, Vanessa, McKeever, Stephen, Kelleher, Andrea, Scholefield, Barney, Top, Anke, Kelly, Nicola, Virdee, Satnam, Davis, Peter, George, Susan, Hawkins, Kay C., McCall, Katie, Brown, Victoria, Sykes, Kim, Levin, Richard, MacLeod, Isobel, Horan, Marie, Jirasek, Petr, Inwald, David, Abdulla, Amina, Raghunanan, Sophie, Taylor, Bob, Shefler, Alison, Sparkes, Hannah, Hanson, Sheila, Woods, Katherine, Triscari, David, Murkowski, Kathy, Ozment, Caroline, Steiner, Marie, Nerheim, Dan, Galster, Amanda, Higgerson, Renee, Christie, LeeAnn, Spinella, Philip C., Martin, Daniel, Rourke, Liz, Muszynski, Jennifer, Steele, Lisa, Ajizian, Samuel, McCrory, Michael C., O’Brien, Kevin, Babbitt, Christopher, Felkel, Erin, Levine, Glenn, Truemper, Edward J., Zink, Machelle, Nellis, Marianne, Thomas, Neal J., Spear, Debbie, Markovitz, Barry, Terry, Jeff, Morzov, Rica, Montgomery, Vicki, Michael, Andrew, Thomas, Melissa, Singleton, Marcy, Jarvis, Dean, Nett, Sholeen, Willson, Douglas, Hoot, Michelle, Bembea, Melania, Yiu, Alvin, McKinley, David, Scarlett, Elizabeth, Sankey, Jennifer, Parikh, Minal, Faustino, E. Vincent S., Michelson, Kelly, Rilinger, Jay, Campbell, Laura, Gertz, Shira, Cholette, Jill M., Jeyapalan, Asumthia, Parker, Margaret, Bateman, Scot, Johnson, Amanda, and for the PlasmaTV investigators

Published
2016
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20. Association Between Early Change in Arterial Carbon Dioxide Tension and Outcomes in Neonates Treated by Extracorporeal Membrane Oxygenation

Author

Joram, Nicolas, primary, Rozé, Jean-Christophe, additional, Tonna, Joseph E., additional, Rycus, Peter, additional, Beqiri, Erta, additional, Pezzato, Stefano, additional, Moscatelli, Andrea, additional, Robba, Chiara, additional, Liet, Jean-Michel, additional, Bourgoin, Pierre, additional, Czosnyka, Marek, additional, Léger, Pierre-Louis, additional, Rambaud, Jérôme, additional, Smielewski, Peter, additional, and Chenouard, Alexis, additional

Published
2022
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21. Factors influencing plasma transfusion practices in paediatric intensive care units around the world

Author

Karam, O., Demaret, P., Duhamel, A., Shefler, A., Spinella, P. C., Tucci, M., Leteurtre, S., Stanworth, S. J., Butt, Warwick, Elope, Carmel, Bain, Kym, Erickson, Simon, Smalley, Nathan, Dorofaeff, Tavey, Long, Debbie, Smalley, Nathan, Wiseman, Greg, de Cléty, Stéphan Clément, Berghe, Caroline, de Jaeger, Annick, Trippaerts, Marc, Willems, Ariane, Rooze, Shancy, De Dooy, Jozef, Gilfoyle, Elaine, Wohlgemuth, Lynette, Dumitrascu, Mariana, Withington, Davinia, Hickey, Julia, Choong, Karen, Sanders, Lois, Morrison, Gavin, Tijssen, Janice, Wensley, David, Krahn, Gordon, Dugas, MarcAndre, Gosselin, Louise, Santschi, Miriam, Von Dessauer, Bettina, Ordenes, Nadia, Afshari, Arash, Andersen, Lasse Hoegh, Nilsson, Jens Christian, Johansen, Mathias, Jensen, AnneMette Baek, Mino, Santiago Campos, Grunauer, Michelle, Joram, Nicolas, RoulletRenoleau, Nicolas, Javouhey, Etienne, CourAndlauer, Fleur, Portefaix, Aurélie, Brissaud, Olivier, Guichoux, Julie, Payen, Valérie, Léger, PierreLouis, Afanetti, Mickael, Mortamet, Guillaume, Maria, Matthieu, Breining, Audrey, Tissieres, Pierre, Dorkenoo, Aimée, Deho, Anna, Steinherr, Harry, Nikolaou, Filippia, Camporesi, Anna, Mario, Federica, Kawasaki, Tatsuya, Miura, Shinya, Beca, John, Rea, Miriam, Sherring, Claire, Bushell, Tracey, Bentsen, Gunnar, Dinis, Alexandra, Pereira, Gabriela, Vieira, Marisa, Moniz, Marta, Alshehri, Saleh, Alasnag, Manal, Rajab, Ahmad, Pisarcikova, Maria, Jordan, Iolanda, Balcells, Joan, PerezFerrer, Antonio, de Vicente Sánchez, Jesús, Moyano, Marta Vazquez, Martinez, Antonio Morales, LopezHerce, Jesus, Solana, Maria Jose, González, Jose Carlos Flores, Alonso, Maria Teresa, Faza, Manuel Nieto, Perez, MarieHélène, Amiet, Vivianne, Doell, Carsten, Bordessoule, Alice, Otter, Suzan Cochiusden, Kapitein, Berber, Kneyber, Martin, Brierley, Joe, Rea, Vanessa, McKeever, Stephen, Kelleher, Andrea, Scholefield, Barney, Top, Anke, Kelly, Nicola, Virdee, Satnam, Davis, Peter, George, Susan, Hawkins, Kay C, McCall, Katie, Brown, Victoria, Sykes, Kim, Levin, Richard, MacLeod, Isobel, Horan, Marie, Jirasek, Petr, Inwald, David, Abdulla, Amina, Raghunanan, Sophie, Sparkes, Hannah, Hanson, Sheila, Woods, Katherine, Triscari, David, Murkowski, Kathy, Ozment, Caroline, Steiner, Marie, Nerheim, Dan, Galster, Amanda, Higgerson, Renee, Christie, LeeAnn, Martin, Daniel, Rourke, Liz, Muszynski, Jennifer, Steele, Lisa, Ajizian, Samuel, McCrory, Michael C, OʼBrien, Kevin, Babbitt, Christopher, Felkel, Erin, Levine, Glenn, Truemper, Edward J, Zink, Machelle, Nellis, Marianne, Thomas, Neal J, Spear, Debbie, Markovitz, Barry, Terry, Jeff, Morzov, Rica, Montgomery, Vicki, Michael, Andrew, Thomas, Melissa, Singleton, Marcy, Jarvis, Dean, Nett, Sholeen, Willson, Douglas, Hoot, Michelle, Bembea, Melania, Yiu, Alvin, McKinley, David, Scarlett, Elizabeth, Sankey, Jennifer, Parikh, Minal, Faustino, E. Vincent S., Michelson, Kelly, Rilinger, Jay, Campbell, Laura, Gertz, Shira, Cholette, Jill M., Jeyapalan, Asumthia, Parker, Margaret, Bateman, Scot, and Johnson, Amanda

Published
2017
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24. Strategies to reduce curative antibiotic therapy in intensive care units (adult and paediatric)

Author

Bretonnière, Cédric, Leone, Marc, Milési, Christophe, Allaouchiche, Bernard, Armand-Lefevre, Laurence, Baldesi, Olivier, Bouadma, Lila, Decré, Dominique, Figueiredo, Samy, Gauzit, Rémy, Guery, Benoît, Joram, Nicolas, Jung, Boris, Lasocki, Sigismond, Lepape, Alain, Lesage, Fabrice, Pajot, Olivier, Philippart, François, Souweine, Bertrand, Tattevin, Pierre, Timsit, Jean-François, Vialet, Renaud, Zahar, Jean Ralph, Misset, Benoît, and Bedos, Jean-Pierre

Published
2015
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25. Evolution du capacitaire et des ressources humaines en réanimation après la première vague de la pandémie COVID-19 : une enquête du Syndicat des Médecins Réanimateurs

Author

SMR, Syndicat des Médecins Réanimateurs, primary, Federici, Laura, additional, Lesieur, Olivier, additional, Sement, Arnaud, additional, Chagnon, Jean-Luc, additional, Rigaud, Jean-Philippe, additional, Diehl, Jean-Luc, additional, Dreyfuss, Didier, additional, Guiot, Philippe, additional, Joram, Nicolas, additional, Outin, Hervé, additional, Sevens, Chantal, additional, Thévenin, Didier, additional, Touati, Samia, additional, Annane, Djillali, additional, and Terzi, Nicolas, additional

Published
2022
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26. Regional citrate anticoagulation for pediatric CRRT using integrated citrate software and physiological sodium concentration solutions

Author

Liet, Jean-Michel, Allain-Launay, Emma, Gaillard-LeRoux, Benedicte, Barriere, Francois, Chenouard, Alexis, Dejode, Jean- Marc, and Joram, Nicolas

Subjects
Acute renal failure -- Research -- Care and treatment -- Patient outcomes -- Demographic aspects, Pediatric intensive care -- Research, Health
Abstract

Background In continuous renal replacement therapy (CRRT), regional citrate anticoagulation offers an attractive alternative to heparinization, especially for children with a high bleeding risk. Methods We report on a new management approach to CRRT using integrated citrate software and physiological sodium concentration solutions. Convective filtration was performed with pre-filter citrate anticoagulation using an 18 mmol/L citrate solution and a post-filter replacement fluid. The citrate flow rate was automatically adjusted to the blood flow rate by means of integrated citrate software. Similarly, calcium was automatically infused into children to maintain their blood calcium levels within normal range. Results Eleven CRRT sessions were performed (330 h) in seven critically ill children aged 3-15 years (extreme values 15-66 kg). Disease categories included sepsis withmultiorgan dysfunction (n=2) and hemolytic uremic syndrome (n=5). Median effluent dose was 2.1 (extreme values 1.7-3.3) L/h/ 1.73 [m.sup.2]. No session had to be stopped because of metabolic complications. Calcium levels, both in the circuits and in the circulating blood of the children, remained stable and secure. Conclusions Regional citrate anticoagulation can be used in children with a body weight of >15 kg using integrated citrate software and commercially available solutions with physiological sodium concentrations in a safe, effective and convenient procedure. Keywords Continuous venovenous hemofiltration * Children * Citrate anticoagulation * Acute kidney injury * Continuous renal replacement therapy * Pediatric intensive care, Introduction In continuous renal replacement therapy (CRRT), regional citrate anticoagulation offers an attractive alternative to heparinization, especially in patients with a high bleeding risk since they do not have to [...]

Published
2014
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27. Stratégies de réduction de l’utilisation des antibiotiques à visée curative en réanimation (adulte et pédiatrique)

Author

Bédos, Jean-Pierre, Allaouchiche, Bernard, Armand-Lefèvre, Laurence, Baldesi, Olivier, Bouadma, Lila, Decré, Dominique, Figueiredo, Samy, Gauzit, Rémy, Guery, Benoit, Joram, Nicolas, Jung, Boris, Lasocki, Sigismond, Lepape, Alain, Lesage, Fabrice, Pajot, Olivier, Philippart, François, Souweine, Bertrand, Tattevin, Pierre, Timsit, Jean-François, Zahar, Jean-Ralph, Bretonnière, Cédric, Leone, Marc, Milési, Christophe, and Misset, Benoît

Published
2014
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28. Continuous Amplitude-Integrated Electroencephalography During Neonatal and Pediatric Extracorporeal Membrane Oxygenation

Author

Chahine, Adela, primary, Chenouard, Alexis, additional, Joram, Nicolas, additional, Berthomieu, Lionel, additional, Du Pont-Thibodeau, Geneviève, additional, Leclere, Brice, additional, Liet, Jean-Michel, additional, Maminirina, Pierre, additional, Leclair-Visonneau, Laurène, additional, Breinig, Sophie, additional, and Bourgoin, Pierre, additional

Published
2021
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31. Monocytic Human Leukocyte Antigen DR Expression in Young Infants Undergoing Cardiopulmonary Bypass

Author

Chenouard, Alexis, primary, Rimbert, Marie, additional, Joram, Nicolas, additional, Braudeau, Cécile, additional, Roquilly, Antoine, additional, Bourgoin, Pierre, additional, Asehnoune, Karim, additional, Chenouard, Alexis, additional, Salabert, Nina, additional, Vourc'h, Mickaël, additional, Josien, Régis, additional, and Gras-Leguen, Christèle, additional

Published
2021
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32. Intensive care units, the Achilles heel of France in the COVID-19 battle

Author

Annane, Djillali, primary, Federici, Laura, additional, Chagnon, Jean-Luc, additional, Diehl, Jean Luc, additional, Dreyfuss, Didier, additional, Guiot, Philippe, additional, Javouhey, Etienne, additional, Joram, Nicolas, additional, Lesieur, Olivier, additional, Rigaud, Jean Philippe, additional, Outin, Hervé, additional, Sement, Arnaud, additional, Sevens, Chantal, additional, Thévenin, Didier, additional, Touati, Samia, additional, and Terzi, Nicolas, additional

Published
2021
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34. Continuous Monitoring of Cerebral Autoregulation in Children Supported by Extracorporeal Membrane Oxygenation: A Pilot Study

Author

Joram, Nicolas, primary, Beqiri, Erta, additional, Pezzato, Stefano, additional, Andrea, Moscatelli, additional, Robba, Chiara, additional, Liet, Jean-Michel, additional, Chenouard, Alexis, additional, Bourgoin, Pierre, additional, Czosnyka, Marek, additional, Léger, Pierre-Louis, additional, and Smielewski, Peter, additional

Published
2020
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37. Complex Compound Inheritance of Lethal Lung Developmental Disorders due to Disruption of the TBX-FGF Pathway

Author

Karolak, Justyna A, Vincent, Marie, Deutsch, Gail, Gambin, Tomasz, Cogné, Benjamin, Pichon, Olivier, Vetrini, Francesco, Mefford, Heather C, Dines, Jennifer N, Golden-Grant, Katie, Dipple, Katrina, Freed, Amanda S, Leppig, Kathleen A, Dishop, Megan, Mowat, David, Bennetts, Bruce, Gifford, Andrew J, Weber, Martin A, Lee, Anna F, Boerkoel, Cornelius F, Bartell, Tina M, Ward-Melver, Catherine, Besnard, Thomas, Petit, Florence, Bache, Iben, Tümer, Zeynep, Denis-Musquer, Marie, Joubert, Madeleine, Martinovic, Jelena, Bénéteau, Claire, Molin, Arnaud, Carles, Dominique, André, Gwenaelle, Bieth, Eric, Chassaing, Nicolas, Devisme, Louise, Chalabreysse, Lara, Pasquier, Laurent, Secq, Véronique, Don, Massimiliano, Orsaria, Maria, Missirian, Chantal, Mortreux, Jérémie, Sanlaville, Damien, Pons, Linda, Küry, Sébastien, Bézieau, Stéphane, Liet, Jean-Michel, Joram, Nicolas, Bihouée, Tiphaine, Scott, Daryl A, Brown, Chester W, Scaglia, Fernando, Tsai, Anne Chun-Hui, Grange, Dorothy K, Phillips, John A, Pfotenhauer, Jean P, Jhangiani, Shalini N, Gonzaga-Jauregui, Claudia G, Chung, Wendy K, Schauer, Galen M, Lipson, Mark H, Mercer, Catherine L, van Haeringen, Arie, Liu, Qian, Popek, Edwina, Coban Akdemir, Zeynep H, Lupski, James R, Szafranski, Przemyslaw, Isidor, Bertrand, Le Caignec, Cedric, Stankiewicz, Paweł, Karolak, Justyna A, Vincent, Marie, Deutsch, Gail, Gambin, Tomasz, Cogné, Benjamin, Pichon, Olivier, Vetrini, Francesco, Mefford, Heather C, Dines, Jennifer N, Golden-Grant, Katie, Dipple, Katrina, Freed, Amanda S, Leppig, Kathleen A, Dishop, Megan, Mowat, David, Bennetts, Bruce, Gifford, Andrew J, Weber, Martin A, Lee, Anna F, Boerkoel, Cornelius F, Bartell, Tina M, Ward-Melver, Catherine, Besnard, Thomas, Petit, Florence, Bache, Iben, Tümer, Zeynep, Denis-Musquer, Marie, Joubert, Madeleine, Martinovic, Jelena, Bénéteau, Claire, Molin, Arnaud, Carles, Dominique, André, Gwenaelle, Bieth, Eric, Chassaing, Nicolas, Devisme, Louise, Chalabreysse, Lara, Pasquier, Laurent, Secq, Véronique, Don, Massimiliano, Orsaria, Maria, Missirian, Chantal, Mortreux, Jérémie, Sanlaville, Damien, Pons, Linda, Küry, Sébastien, Bézieau, Stéphane, Liet, Jean-Michel, Joram, Nicolas, Bihouée, Tiphaine, Scott, Daryl A, Brown, Chester W, Scaglia, Fernando, Tsai, Anne Chun-Hui, Grange, Dorothy K, Phillips, John A, Pfotenhauer, Jean P, Jhangiani, Shalini N, Gonzaga-Jauregui, Claudia G, Chung, Wendy K, Schauer, Galen M, Lipson, Mark H, Mercer, Catherine L, van Haeringen, Arie, Liu, Qian, Popek, Edwina, Coban Akdemir, Zeynep H, Lupski, James R, Szafranski, Przemyslaw, Isidor, Bertrand, Le Caignec, Cedric, and Stankiewicz, Paweł

Abstract

Primary defects in lung branching morphogenesis, resulting in neonatal lethal pulmonary hypoplasias, are incompletely understood. To elucidate the pathogenetics of human lung development, we studied a unique collection of samples obtained from deceased individuals with clinically and histopathologically diagnosed interstitial neonatal lung disorders: acinar dysplasia (n = 14), congenital alveolar dysplasia (n = 2), and other lethal lung hypoplasias (n = 10). We identified rare heterozygous copy-number variant deletions or single-nucleotide variants (SNVs) involving TBX4 (n = 8 and n = 2, respectively) or FGF10 (n = 2 and n = 2, respectively) in 16/26 (61%) individuals. In addition to TBX4, the overlapping ∼2 Mb recurrent and nonrecurrent deletions at 17q23.1q23.2 identified in seven individuals with lung hypoplasia also remove a lung-specific enhancer region. Individuals with coding variants involving either TBX4 or FGF10 also harbored at least one non-coding SNV in the predicted lung-specific enhancer region, which was absent in 13 control individuals with the overlapping deletions but without any structural lung anomalies. The occurrence of rare coding variants involving TBX4 or FGF10 with the putative hypomorphic non-coding SNVs implies a complex compound inheritance of these pulmonary hypoplasias. Moreover, they support the importance of TBX4-FGF10-FGFR2 epithelial-mesenchymal signaling in human lung organogenesis and help to explain the histopathological continuum observed in these rare lethal developmental disorders of the lung.

Published
2019

38. Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Author

Pedersen, Dennis V., Gadeberg, Trine Amalie Fogh, Thomas, Caroline, Wang, Yong, Joram, Nicolas, Jensen, Rasmus Kjeldsen, Mazarakis, Sofia M. M., Revel, Margot, El Sissy, Carine, Petersen, Steen V., Lindorff-Larsen, Kresten, Thiel, Steffen, Laursen, Nick Stub, Fremeaux-Bacchi, Véronique, Andersen, Gregers Rom, Pedersen, Dennis V., Gadeberg, Trine Amalie Fogh, Thomas, Caroline, Wang, Yong, Joram, Nicolas, Jensen, Rasmus Kjeldsen, Mazarakis, Sofia M. M., Revel, Margot, El Sissy, Carine, Petersen, Steen V., Lindorff-Larsen, Kresten, Thiel, Steffen, Laursen, Nick Stub, Fremeaux-Bacchi, Véronique, and Andersen, Gregers Rom

Published
2019

39. Enhance quality care performance: Determination of the variables for establishing a common database in French paediatric critical care units

Author

RECHER, Morgan, BERTRAC, Caroline, Guillot, Camille, BAUDELET, Jean Benoit, KARACA-ALTINTAS, Yasemin, HUBERT, Hervé, Leclerc, Francis, Leteurtre, Stéphane, DEVICTOR, Denis, Chevret, Laurent, Javouhey, Etienne, VANEL, Blandine, Valla, Frédéric, Cambonie, Gilles, Milesi, Christophe, LIET, JeanMichel, Joram, Nicolas, HUBERT, Philippe, DUPIC, Laurent, Ozanne, Bruno, Tirel, Olivier, Dauger, Stéphane, Desprez, Philippe, CHANTREUIL, Julie, Réanimation Pédiatrique, CHU Lille, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), CHU Lyon, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), NeckerEnfant Malades, parent, CHU Rennes, CHU Strasbourg, CHU Tours, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), and Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)

Subjects
Databases, Factual, Delphi Technique, DATABASE, [SDV]Life Sciences [q-bio], Australia, Original Articles, Intensive Care Units, Pediatric, Quality Improvement, United States, critical care, paediatrics, Humans, Original Article, France, Registries, Child, Quality of Health Care
Abstract

Selected variables for the French Paediatric Intensive Care registry. Rationale, aims, and objectives Providing quality care requires follow‐up in regard to clinical and economic activities. Over the past decade, medical databases and patient registries have expanded considerably, particularly in paediatric critical care medicine (eg, the Paediatric Intensive Care Audit Network (PICANet) in the UK, the Australian and New Zealand Paediatric Intensive Care (ANZPIC) Registry in Australia and New Zealand, and the Virtual Paediatric Intensive Care Unit Performance System (VPS) in the USA). Such a registry is not yet available in France. The aim of this study was to determine variables that ought to be included in a French paediatric critical care registry. Methods Variables, items, and subitems from 3 foreign registries and 2 French local databases were used. Items described each variable, and subitems described items. The Delphi method was used to evaluate and rate 65 variables, 90 items, and 17 subitems taking into account importance or relevance based on input from 28 French physicians affiliated with the French Paediatric Critical Care Group. Two ratings were used between January and May 2013. Results Fifteen files from 10 paediatric intensive care units were included. Out of 65 potential variables, 48 (74%) were considered to be indispensable, 16 (25%) were considered to be optional, and 1 (2%) was considered to be irrelevant. Out of 90 potential items, 62 (69%) were considered to be relevant, 23 (26%) were considered to be of little relevance, and 5 (6%) were considered to be irrelevant. Out of 17 potential subitems, 9 (53%) were considered to be relevant, 6 (35%) were considered to be of little relevance, and 2 (12%) were considered to be irrelevant. Conclusions The necessary variables that ought to be included in a French paediatric critical care registry were identified. The challenge now is to develop the French registry for paediatric intensive care units.

Published
2018

40. Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

Author

Pedersen, Dennis V., primary, Gadeberg, Trine A. F., additional, Thomas, Caroline, additional, Wang, Yong, additional, Joram, Nicolas, additional, Jensen, Rasmus K., additional, Mazarakis, Sofia M. M., additional, Revel, Margot, additional, El Sissy, Carine, additional, Petersen, Steen V., additional, Lindorff-Larsen, Kresten, additional, Thiel, Steffen, additional, Laursen, Nick S., additional, Fremeaux-Bacchi, Véronique, additional, and Andersen, Gregers R., additional

Published
2019
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41. Complex Compound Inheritance of Lethal Lung Developmental Disorders Due to Disruption of the TBX-FGF Pathway

Author

Karolak, Justyna A., primary, Vincent, Marie, additional, Deutsch, Gail, additional, Gambin, Tomasz, additional, Cogné, Benjamin, additional, Pichon, Olivier, additional, Vetrini, Francesco, additional, Mefford, Heather C., additional, Dines, Jennifer N., additional, Golden-Grant, Katie, additional, Dipple, Katrina, additional, Freed, Amanda S., additional, Leppig, Kathleen A., additional, Dishop, Megan, additional, Mowat, David, additional, Bennetts, Bruce, additional, Gifford, Andrew J., additional, Weber, Martin A., additional, Lee, Anna F., additional, Boerkoel, Cornelius F., additional, Bartell, Tina M., additional, Ward-Melver, Catherine, additional, Besnard, Thomas, additional, Petit, Florence, additional, Bache, Iben, additional, Tümer, Zeynep, additional, Denis-Musquer, Marie, additional, Joubert, Madeleine, additional, Martinovic, Jelena, additional, Bénéteau, Claire, additional, Molin, Arnaud, additional, Carles, Dominique, additional, André, Gwenaelle, additional, Bieth, Eric, additional, Chassaing, Nicolas, additional, Devisme, Louise, additional, Chalabreysse, Lara, additional, Pasquier, Laurent, additional, Secq, Véronique, additional, Don, Massimiliano, additional, Orsaria, Maria, additional, Missirian, Chantal, additional, Mortreux, Jérémie, additional, Sanlaville, Damien, additional, Pons, Linda, additional, Küry, Sébastien, additional, Bézieau, Stéphane, additional, Liet, Jean-Michel, additional, Joram, Nicolas, additional, Bihouée, Tiphaine, additional, Scott, Daryl A., additional, Brown, Chester W., additional, Scaglia, Fernando, additional, Tsai, Anne Chun-Hui, additional, Grange, Dorothy K., additional, Phillips, John A., additional, Pfotenhauer, Jean P., additional, Jhangiani, Shalini N., additional, Gonzaga-Jauregui, Claudia G., additional, Chung, Wendy K., additional, Schauer, Galen M., additional, Lipson, Mark H., additional, Mercer, Catherine L., additional, van Haeringen, Arie, additional, Liu, Qian, additional, Popek, Edwina, additional, Coban Akdemir, Zeynep H., additional, Lupski, James R., additional, Szafranski, Przemyslaw, additional, Isidor, Bertrand, additional, Le Caignec, Cedric, additional, and Stankiewicz, Paweł, additional

Published
2019
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42. Respiratory support by neurally adjusted ventilatory assist (NAVA) in severe RSV-related bronchiolitis: a case series report

Author

Rozé Jean-Christophe, Bétrémieux Pierre, Roux Bénédicte, Joram Nicolas, Dejode Jean-Marc, and Liet Jean-Michel

Subjects
Pediatrics, RJ1-570
Abstract

Abstract Background Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation controlled by diaphragmatic electrical signals. The electrical signals allow synchronization of ventilation to spontaneous breathing efforts of a child, as well as permitting pressure assistance proportional to the electrical signal. NAVA provides equally fine synchronization of respiratory support and pressure assistance varying with the needs of the child. NAVA has mainly been studied in children who underwent cardiac surgery during the period of weaning from a respirator. Case presentation We report here a series of 3 children (1 month, 3 years, and 28 days old) with severe respiratory distress due to RSV-related bronchiolitis requiring invasive mechanical ventilation with a high level of oxygen (FiO2 ≥50%) for whom NAVA facilitated respiratory support. One of these children had diagnosis criteria for acute lung injury, another for acute respiratory distress syndrome. Establishment of NAVA provided synchronization of mechanical ventilatory support with the breathing efforts of the children. Respiratory rate and inspiratory pressure became extremely variable, varying at each cycle, while children were breathing easily and smoothly. All three children demonstrated less oxygen requirements after introducing NAVA (57 ± 6% to 42 ± 18%). This improvement was observed while peak airway pressure decreased (28 ± 3 to 15 ± 5 cm H2O). In one child, NAVA facilitated the management of acute respiratory distress syndrome with extensive subcutaneous emphysema. Conclusions Our findings highlight the feasibility and benefit of NAVA in children with severe RSV-related bronchiolitis. NAVA provides a less aggressive ventilation requiring lower inspiratory pressures with good results for oxygenation and more comfort for the children.

Published
2011
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43. Necrotizing soft-tissue infections in pediatric intensive care: a prospective multicenter case-series study.

Author

Dauger, Stéphane, Blondé, Renaud, Brissaud, Olivier, Marcoux, Marie-Odile, Angoulvant, François, Levy, Michael, Groupe Francophone de Réanimation et Urgences Pédiatriques (GFRUP), Balu, Laurent, Gatti, Hélène, Javouhey, Etienne, Joram, Nicolas, Lesage, Fabrice, Milesi, Christophe, Perez, Marie-Hélène, Wroblewski, Isabelle, Réseau Mères-Enfants de la Francophonie (RMEF), and Dugas, Marc-André

Published
2021
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44. Right watershed cerebral infarction following neck cannulation for veno-arterial extracorporeal membrane oxygenation in pediatric septic shock: a case series.

Author

Chenouard, Alexis, Toulgoat, Frédérique, Rolland, Anne, Liet, Jean-Michel, Maminirina, Pierre, Joram, Nicolas, and Bourgoin, Pierre

Subjects
SEPTIC shock treatment, BRAIN, ELECTROENCEPHALOGRAPHY, CEREBRAL infarction, CENTRAL venous catheterization, CEREBRAL circulation, EXTRACORPOREAL membrane oxygenation, TRANSCRANIAL Doppler ultrasonography, MAGNETIC resonance imaging
Abstract

Children supported by extracorporeal membrane oxygenation present a high risk of neurological complications. Although carotid cannulation is known to be associated with neurologic injury, conflicting data exist with regard to the predominance of right- or left-sided lesions. We describe here two infants requiring veno-arterial extracorporeal membrane oxygenation for septic shock who encountered right watershed infarction ipsilateral to carotid artery cannulation. Hemodynamic failure seems to be the most probable underlying mechanism. The asymmetry of transcranial Doppler metrics in one case and the low right regional cerebral oxygen saturation value observed soon after right cannulation in both cases suggest an insufficient cerebral collateral flow compensation. The risk of ipsilateral watershed injury should be considered before cervical cannulation, notably in the context of sepsis and an evaluation of the cerebral collateral blood flow before and just after cannulation may be interesting in order to identify infants with higher risk of ipsilateral ischemic lesions. [ABSTRACT FROM AUTHOR]

Published
2021
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47. The authors reply

Author

Gaillard-Le Roux, Bénédicte, primary, Liet, Jean-Michel, additional, Bourgoin, Pierre, additional, and Joram, Nicolas, additional

Published
2017
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