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1. Contents Vol. 88, 2012

Author

Byung-Il Yoon, Metin İshak Öztürk, Ali Unsal, J.J.D.M. van Lankveld, J.J. Kim, U. van den Hombergh, Yaşar Bozkurt, Berkan Resorlu, W. Meinhardt, Jae Hyun Bae, N. Gielen, Baojie Ma, Jerzy Siekiera, R.R. de Vries, Abdullah Ilktac, S.G. Kang, Jin Bong Choi, J. Cheon, Yuemin Xu, Krzysztof Kamecki, Sae-Woong Kim, H.A. Jang, Carsten Kempkensteffen, J.H. Bae, Joon-Sung Koh, Hua Lei, Massimiliano Creta, Witold Mikołajczak, Pardeep Kumar, Sang Jin Yoon, Antonella De Rosa, E.P. van Haarst, A.C. van Voskuilen, Tarik Amer, Dong Choon Park, Frédéric Thibault, J.G. Lee, Kurt Miller, Matthew Bultitude, Dimitra Kyrou, Mathieu Rouanne, M. Ihsan Karaman, Muzaffer Oğuz Keleş, Vincenzo Mirone, Jonas Busch, Steffen Weikert, P.E.V. van Kerrenbroeck, Druck Reinhardt Druck Basel, Ranlu Liu, P. Kauer, C.G.M.I. Baeten, Seong-Yeon Hwang, S. Cho, Guido Fechner, Jang-Chun Woo, S.H. Kang, Hoon Jang, Weigang Yan, Dexin Dong, Hyun-Sop Choe, Hanzhong Li, A. Bex, Athanasios Papatsoris, Haluk Söylemez, Hae Joon Kim, H.G. van der Poel, Jae Heon Kim, Krzysztof Kraśnicki, Hongtuan Zhang, Rajinikanth Ayyathurai, Prashanth Kanagarajah, Stefan Hinz, Novera G. Chughtai, Murat Tuken, Khae Hawn Kim, Umar Saleem, Stefan Müller, Jörg Ellinger, Milosz Jasinski, Mohammed Shamim Khan, Stefan Hauser, Andrzej Wronczewski, Nicola Longo, Paolo Verze, D.J. Oerlemans, Nicholas J. Hegarty, Dejuan Wang, Xihui Chen, Guillaume Legrand, Ewa Chmielowska, Xiaolu Wang, Jianguang Qiu, Satz Mengensatzproduktion, Yong Xu, Shahid Khan, Zhigang Ji, S. Horenblas, U-Syn Ha, Raheela Mohsin Rizvi, E.H.J. Weil, Sebastian Rogenhofer, Alessandro Palmieri, Bogdan Małkowski, Ciro Imbimbo, Ante Reljić, Alessandro Maletta, Emmanuel Chartier-Kastler, Youqiang Fang, Ahmed Magheli, Raphaëlle Renard-Penna, Hyo-Sin Kim, Tomasz Pietrzak, Davor Trnski, Dimitris Staios, Orhan Koca, H. van Tinteren, Tomasz Drewa, Barbara Erber, Timo Strunk, Marc Olivier Bitker, Ferdinando Fusco, Xin Gao, Quanzong Mao, Won Jin Lee, Baojun Gu, Seung-Ju Lee, Kamran Ahmed, Sung Ryul Shim, Su-Jin Kim, S.M.P. Lansen-Koch, Liang Li, Wojciech Jóźwicki, Y.H. Ko, Andrzej Petrus, Christian Klopf, Murugesan Manoharan, Xiaoxu Yan, Dong Sup Lee, and Piotr Chlosta

Subjects
Traditional medicine, business.industry, Urology, Medicine, business
Published
2012
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2. Cyanidin-3-O-β-D-glucopyranoside concentrated materials from mulberry fruit have a potency to protect erectile function by minimizing oxidative stress in a rat model of diabetic erectile dysfunction

Author

U-Syn Ha, Su Jin Kim, Hoon Jang, Byung-Il Yoon, Jang-Chun Woo, Hyo-Sin Kim, Seong-Yeon Hwang, Sae-Woong Kim, and Joon-Sung Koh

Subjects
Male, medicine.medical_specialty, Nitric Oxide Synthase Type III, Urology, Cyanidin, Apoptosis, Nitric Oxide Synthase Type I, medicine.disease_cause, Antioxidants, Diabetes Mellitus, Experimental, Anthocyanins, Diabetes Complications, Rats, Sprague-Dawley, chemistry.chemical_compound, Erectile Dysfunction, Internal medicine, Diabetes mellitus, In Situ Nick-End Labeling, Medicine, Potency, Animals, business.industry, Superoxide Dismutase, Penile Erection, Deoxyguanosine, Erectile function, Streptozotocin, medicine.disease, Rats, Oxidative Stress, Endocrinology, Erectile dysfunction, chemistry, 8-Hydroxy-2'-Deoxyguanosine, Fruit, Morus, business, Oxidative stress, medicine.drug, Penis
Abstract

Objective: The aim of this study was to evaluate the effect of cyanidin-3-O-β-D-glucopyranoside (C3G) concentrated materials from mulberry fruit on improvement and protection of erectile function. Materials and Methods: Sprague-Dawley rats (12 weeks old) were divided into three groups (n = 12 in each): normal control, diabetes mellitus (DM), and DM with C3G concentrated material treatment (DM + C3G). DM and DM + C3G group rats received a single injection of streptozotocin (50 mg/kg), and 4 weeks after induction of diabetes, the DM + C3G group rats were treated with daily concentrated material treatment (10 mg/kg) dissolved in water for 8 weeks. After 12 weeks of streptozotocin injections, the rats in each group underwent intracavernosal pressure measurement and then the corporal tissues were sampled. Results: The DM group rats showed markedly lower erectile parameters than those in the control group, whereas rats in the DM + C3G group showed improved erectile function by minimizing corporal apoptosis and increasing the expression of endothelial nitric oxide synthase (NOS) and neuronal NOS protein. A significant increase in 8-hydroxy-2-deoxyguanosine (8-OHdG) was shown in the DM group compared with the normal group. However, in the DM + C3G group, 8-OHdG was statistically significantly reduced compared with the DM group. Conclusions: The current study is the first to suggest that C3G concentrated materials may have a potency to improve and protect erectile function under conditions of diabetes-induced oxidative stress.

Published
2011

3. The Effect of Cyanidin-3-O-β-d-glucopyranoside on the Penile Erection and Corpus Cavernosum in a Rat Model of Diabetic Erectile Dysfunction

Author

Suk Ju Kim, Jang Chun Woo, Byung Il Yoon, Sae Woong Kim, Joon Sung Koh, Seong Yeon Hwang, Hoon Jang, Su Jin Kim, and U Syn Ha

Subjects
medicine.medical_specialty, business.industry, Cyanidin, Rat model, Single injection, medicine.disease, Streptozotocin, chemistry.chemical_compound, Erectile dysfunction, Endocrinology, chemistry, Internal medicine, Diabetes mellitus, Medicine, Potency, business, Normal control, medicine.drug
Abstract

Purpose: The aim of this study was to evaluate Cyanidin-3-O-β-d-glucopyranoside on improvement and protection for erectile function. Materials and Methods: Sprague-Dawley rats (12wks old) were divided into three groups (n=12 in each): normal control, diabetes (DM), and diabetes with Cyanidin-3-O-β-d-glucopyranoside (C3G) concentration materials treatment (DM＋C3G). DM and DM＋C3G group received a single injection of streptozotocin (50 mg/kg), and 4 wk after induction of diabetes, DM＋C3G group were treated with daily C3G (10 mg/kg) dissolved in water for 8 wk. After 12 wk of streptozotocin injections, rats in each group underwent intracavernosal pressure measurement (ICP) and then the corporal tissues were sampled. Results: DM group showed markedly lower erectile parameters than those in the control group, whereas rats in the DM＋C3G group showed improved erectile function by minimizing corporal apoptosis. Conclusions: The current study is the first to suggest that Cyanidin-3-O-β-d-glucopyranoside may have a potency to improve and protect erectile function in a rat model of diabetic erectile dysfunction.

Published
2011
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