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4 results on '"Joon-Hyung Doh, MD"'

1. 5-Year Outcome of Simple Crossover Stenting in Coronary Bifurcation Lesions Compared With Side Branch Opening

Author

Cheol Hyun Lee, MD, Chang-Wook Nam, MD, Yun-Kyeong Cho, MD, Hyuck-Jun Yoon, MD, Kwon-Bae Kim, MD, Hyeon-Cheol Gwon, MD, Hyo-Soo Kim, MD, Woo Jung Chun, MD, Seung Hwan Han, MD, Seung-Woon Rha, MD, In-Ho Chae, MD, Jin-Ok Jeong, MD, Jung Ho Heo, MD, Junghan Yoon, MD, Do-Sun Lim, MD, Jong-Seon Park, MD, Myeong-Ki Hong, MD, Sung Yun Lee, MD, Kwang Soo Cha, MD, Doo-Il Kim, MD, Jang-Whan Bae, MD, Kiyuk Chang, MD, Byung-Hee Hwang, MD, So-Yeon Choi, MD, Myung Ho Jeong, MD, Ki Hong Choi, MD, Young Bin Song, MD, Soon-Jun Hong, MD, Joon-Hyung Doh, MD, Bon-Kwon Koo, MD, and Seung-Ho Hur, MD

Subjects
bifurcation disease, clinical outcome, percutaneous coronary intervention, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The optimal side branch (SB) treatment strategy after simple crossover stenting in bifurcation lesions is still controversial. Objectives: The purpose of this study was to compare the long-term outcomes of a 1-stent strategy with simple crossover alone versus with an additional SB–opening procedure in patients with left main (LM) and non-LM coronary bifurcation lesions. Methods: Patients who underwent percutaneous coronary intervention with a 1-stent strategy for bifurcation lesions including LM were selected from the COBIS (Coronary Bifurcation Stenting) III registry and divided into the simple crossover–alone group and SB-opening group. Clinical outcomes were assessed by the 5-year rate of target lesion failure (a composite of cardiac death, target vessel myocardial infarction, and target lesion repeat revascularization). Results: Among 2,194 patients who underwent the 1-stent strategy, 1,685 (76.8%) patients were treated with simple crossover alone, and 509 (23.2%) patients were treated with an additional SB-opening procedure. Although the baseline SB angiographic disease was more severe in the SB-opening group, the final lumen diameter of the SB was larger. The 5-year observed target lesion failure rate was similar between the 2 groups (7.0% in the simple crossover vs. 6.7% in SB-opening group; hazard ratio: 0.99; 95% confidence interval: 0.66 to 1.48; p = 0.947), even in the subgroup analyses including LM (9.5% vs. 11.3%; p = 0.442) and true bifurcation (5.3% vs. 7.8%; p = 0.362). The results were not changed after an inverse probability of treatment weighting adjustment. There was no difference in the overall and SB-related target lesion revascularization rate in both groups. Conclusions: The long-term clinical outcome of the 1-stent strategy with simple crossover alone for coronary bifurcation lesions was acceptable compared to those of additional SB-opening procedures. (Korean Coronary Bifurcation Stenting [COBIS] Registry III [COBIS III]; NCT03068494)

Published
2021
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2. Differential Long-Term Effects of First- and Second-Generation DES in Patients With Bifurcation Lesions Undergoing PCI

Author

Ki Hong Choi, MD, Young Bin Song, MD, Joo Myung Lee, MD, Taek Kyu Park, MD, Jeong Hoon Yang, MD, Joo-Yong Hahn, MD, Jin-Ho Choi, MD, Seung-Hyuk Choi, MD, Hyo-Soo Kim, MD, Woo Jung Chun, MD, Seung-Ho Hur, MD, Seung Hwan Han, MD, Seung-Woon Rha, MD, In-Ho Chae, MD, Jin-Ok Jeong, MD, Jung Ho Heo, MD, Junghan Yoon, MD, Do-Sun Lim, MD, Jong-Seon Park, MD, Myeong-Ki Hong, MD, Joon-Hyung Doh, MD, Kwang Soo Cha, MD, Doo-Il Kim, MD, Sang Yeub Lee, MD, Kiyuk Chang, MD, Byung-Hee Hwang, MD, So-Yeon Choi, MD, Myung Ho Jeong, MD, Soon-Jun Hong, MD, Chang-Wook Nam, MD, Bon-Kwon Koo, MD, and Hyeon-Cheol Gwon, MD

Subjects
bifurcation, drug-eluting stents, outcomes, percutaneous coronary intervention, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: There is a paucity of data regarding the long-term clinical outcomes of first- versus second-generation drug-eluting stent (DES), especially when used to treat complex lesions such as bifurcation lesions. Objectives: The current study compares the efficacy and safety of first- versus second-generation DES at the 5-year follow-up in patients who underwent bifurcation percutaneous coronary intervention (PCI). Methods: A total of 5,498 patients with a bifurcation lesion who underwent PCI were pooled at a single patient level from COBIS (Coronary Bifurcation Stenting) registries II and III. Five-year target lesion failure (TLF) (the composite of cardiac death, myocardial infarction [MI], and target lesion revascularization [TLR]) and cardiac death or MI were compared between the use of first-generation DES (n = 2,436) and second-generation DES (n = 3,062) during PCI. Propensity score matching was performed to reduce selection bias. Results: After a 1:1 propensity score matching procedure was conducted, the cohort consisted of 1,702 matched pairs. Patients treated with second-generation DES had a significantly lower risk of TLF at 5 years than those treated with first-generation DES in both overall and propensity-matched populations (matched hazard ratio [HRmatched]: 0.576; 95% confidence interval [CI]: 0.456 to 0.727; p

Published
2021
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3. Prognostic Implications of Comprehensive Whole Vessel Plaque Quantification Using Coronary Computed Tomography Angiography

Author

Seokhun Yang, MD, Joo Myung Lee, MD, MPH, PhD, Masahiro Hoshino, MD, Tadashi Murai, MD, PhD, Ki Hong Choi, MD, Doyeon Hwang, MD, Kyung-Jin Kim, MD, Eun-Seok Shin, MD, PhD, Joon-Hyung Doh, MD, PhD, Hyuk-Jae Chang, MD, PhD, Chang-Wook Nam, MD, PhD, Jinlong Zhang, MD, Jianan Wang, MD, PhD, Shao-Liang Chen, MD, PhD, Nobuhiro Tanaka, MD, PhD, Hitoshi Matsuo, MD, PhD, Takashi Akasaka, MD, PhD, Tsunekazu Kakuta, MD, PhD, and Bon-Kwon Koo, MD, PhD

Subjects
atherosclerosis, coronary CT angiography, fractional flow reserve, plaque quantification, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The prognostic value of whole vessel plaque quantification has not been fully understood. Objectives: We aimed to investigate the clinical relevance of whole vessel plaque quantification on coronary computed tomography angiography. Methods: In a total of 1,013 vessels with fractional flow reserve (FFR) measurement and available coronary computed tomography angiography, high-risk plaque characteristics (HRPC) included minimum lumen area 0.80, the number of HRVC was significantly associated with the risk of VOCO (HR: 2.54; 95% CI: 1.77-3.64) and enhanced the predictability for VOCO of % diameter stenosis and the number of HRPC (P < 0.001). In a landmark analysis at 2 years, the number of HRVC showed sustained prognostic implications beyond 2 years, but the number of HRPC did not. Conclusions: Whole vessel plaque quantification can provide incremental predictability for low FFR and additive prognostic value in deferred vessels with high FFR over anatomical severity and lesion plaque characteristics. (CCTA-FFR Registry for Risk Prediction; NCT04037163)

Published
2021
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