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As the automotive industry transitions from internal combustion engine vehicles to the era of electric cars, extensive research is being conducted in the field of electric vehicles. While a significant portion of this research focuses on the electrification of passenger cars, commercial vehicles have experienced relatively modest changes towards electric propulsion. Particularly, challenges related to power and efficiency have prompted a concentrated effort in addressing these issues. However, improvements in the efficiency of motors and inverters are reaching their limits, necessitating the development of multi-speed transmissions for electric commercial vehicles to enhance overall system efficiency. In this paper, the development of a 4-speed transmission with a synchronizer designed for electric commercial vehicles is presented as part of a project. A transmission shift map was developed, and verification of increased power and efficiency was conducted through a comparison with the existing product (a pneumatic 4-speed internal combustion engine transmission) installed in the target commercial vehicle. The study utilized vehicle dynamics, component modeling, and simulation environments to assess the improvements in performance.

Abstract Loss-of-function mutations in the human oligophrenin-1 (OPHN1) gene cause intellectual disability, a prevailing neurodevelopmental condition. However, the role OPHN1 plays during neuronal development is not well understood. We investigated the role of the Drosophila OPHN1 ortholog Graf in the development of the mushroom body (MB), a key brain structure for learning and memory in insects. We show that loss of Graf causes abnormal crossing of the MB β lobe over the brain midline during metamorphosis. This defect in Graf mutants is rescued by MB-specific expression of Graf and OPHN1. Furthermore, MB α/β neuron-specific RNA interference experiments and mosaic analyses indicate that Graf acts via a cell-autonomous mechanism. Consistent with the negative regulation of epidermal growth factor receptor (EGFR)-mitogen-activated protein kinase (MAPK) signaling by Graf, activation of this pathway is required for the β-lobe midline-crossing phenotype of Graf mutants. Finally, Graf mutants have impaired olfactory long-term memory. Our findings reveal a role for Graf in MB axon development and suggest potential neurodevelopmental functions of human OPHN1.

BMP ligands act as retrograde signalling molecules to regulate presynaptic development, and regulation of BMP receptors by endocytosis may be an important component of this signalling pathway. Here, the authors show that Abi-mediated macropinocytosis of BMP receptors in Drosophila larva and contributes to neuromuscular development.

As interest in image-based rendering increases, the need for multiview inpainting is emerging. Despite of rapid progresses in single-image inpainting based on deep learning approaches, they have no constraint in obtaining color consistency over multiple inpainted images. We target object removal in large-scale indoor spaces and propose a novel pipeline of multiview inpainting to achieve color consistency and boundary consistency in multiple images. The first step of the pipeline is to create color prior information on masks by coloring point clouds from multiple images and projecting the colored point clouds onto the image planes. Next, a generative inpainting network accepts a masked image, a color prior image, imperfect guideline, and two different masks as inputs and yields the refined guideline and inpainted image as outputs. The color prior and guideline input ensure color and boundary consistencies across multiple images. We validate our pipeline on real indoor data sets quantitatively using consistency distance and similarity distance, metrics we defined for comparing results of multiview inpainting and qualitatively.

As the population structure changes due to lower fertility rates and rapid aging, the blood supply available for blood transfusion decreases and demand increases. In most countries, blood management information systems, led by national institutions, operate centrally. However, existing centralized blood management systems have limitations in that they lack detailed blood information and, moreover, information is not reflected in real time. To solve this problem, this paper presents an innovative blood cold chain system based on blockchain technology. The proposed system aims to increase information visibility by recording the overall information on the blood supply and providing detailed blood information such as blood consumption and disposal to the distributed ledger. In addition, this paper proposes direct blood transactions between medical institutions in cases of emergency. Currently, blockchain technologies are being actively employed in the supply chain management and medical fields in addition to financial systems. Particularly, private blockchain techniques with limited participants are relatively fast and reliable, making them suitable for B2B (Business-to-Business) transactions. Therefore, the proposed system is based on the architecture of Hyperledger Fabric, a private blockchain technology implemented by the Hyperledger Composer tool. Information in the proposed blood cold chain system cannot be forged or tampered with, and information recorded and shared in real time is kept transparent. In addition, allowing for B2B blood transaction in special circumstances will minimize the blood supply time and enable patients to be transfused quickly. Moreover, the surplus blood of medical institutions will be used to increase the usage rate relative to the supply amount.

When injecting polymer into an oil reservoir, polymer adsorption onto the grain surface may seriously clog the pore throat and decrease the permeability. This phenomenon may give rise to a severe cross-flow problem in the case of a layered reservoir with a large permeability contrast. Therefore, we proposed a remedial method, which injects polymer solution with different concentrations under the same condition of the frontal velocity at each layer, to overcome the cross-flow problem. In order to perform this task, the experimental system was built as a two-dimensional two-layered sandstone system with a large permeability contrast of 10. From the results of the experimental investigation, conventional polymer flooding was found to be inefficient in oil recovery, because of the cross-flow problem that occurred almost from the beginning of injection. Meanwhile, in the case of the suggested remedial method of polymer flooding, the oil production was significantly enhanced without showing the cross-flow problem, which was accomplished by injecting the polymer solution with different concentrations under the conditions of the same frontal velocity at each layer. Overall, the suggested injecting method was found to be sufficient to overcome the cross-flow problem in a layered reservoir.

BACKGROUND: Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals and humans. A growing body of evidence indicates that MPs can cross the gut barrier and enter into the lymphatic and systemic circulation leading to accumulation in tissues such as the lungs, liver, kidney, and brain. The impacts of mixed MPs exposure on tissue function through metabolism remains largely unexplored. OBJECTIVES: This study aims to investigate the impacts of polymer microspheres on tissue metabolism in mice by assessing the microspheres ability to translocate across the gut barrier and enter into systemic circulation. Specifically, we wanted to examine microsphere accumulation in different organ systems, identify concentration-dependent metabolic changes, and evaluate the effects of mixed microsphere exposures on health outcomes. METHODS: To investigate the impact of ingested microspheres on target metabolic pathways, mice were exposed to either polystyrene (5 μm) microspheres or a mixture of polymer microspheres consisting of polystyrene (5 μm), polyethylene (1–4 μm), and the biodegradability and biocompatible plastic, poly-(lactic-co-glycolic acid) (5 μm). Exposures were performed twice a week for 4 weeks at a concentration of either 0, 2, or 4 mg/week via oral gastric gavage. Tissues were collected to examine microsphere ingress and changes in metabolites. RESULTS: In mice that ingested microspheres, we detected polystyrene microspheres in distant tissues including the brain, liver, and kidney. Additionally, we report on the metabolic differences that occurred in the colon, liver, and brain, which showed differential responses that were dependent on concentration and type of microsphere exposure. DISCUSSION: This study uses a mouse model to provide critical insight into the potential health implications of the pervasive issue of plastic pollution. These findings demonstrate that orally consumed polystyrene or mixed polymer microspheres can accumulate in tissues such as the brain, liver, and kidney. Furthermore, this study highlights concentration-dependent and polymer type-specific metabolic changes in the colon, liver, and brain after plastic microsphere exposure. These results underline the mobility within and between biological tissues of MPs after exposure and emphasize the importance of understanding their metabolic impact [ABSTRACT FROM AUTHOR]