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18. Coronary Artery Calcification Score and the Progression of Chronic Kidney Disease

Author

Yun, Hae-Ryong, Joo, Young Su, Kim, Hyung Woo, Park, Jung Tak, Chang, Tae Ik, Son, Nak-Hoon, Yoo, Tae-Hyun, Kang, Shin-Wook, Sung, Suah, Lee, Kyu-Beck, Lee, Joongyub, Oh, Kook-Hwan, Han, Seung Hyeok, Ahn, Curie, Oh, Kook-Hwan, Han, Seung Seok, Lee, Hajeong, Koh, Young Ok, So, Jeongok, Ko, Seonui, Lee, Aram, Chae, Dong Wan, Jeong, Jong Cheol, Cho, Hyun Jin, Oh, Jung Eun, Lee, Kyu Jin, Yoo, Tae-Hyun, Choi, Kyu Hun, Han, Seung Hyeok, Park, Jung Tak, Hong, Hui Kyung, You, Ji Young, Lee, Kyu-Beck, Hyun, Young Youl, Kim, Hyun Jung, Kim, Yong-Soo, Kim, Yaeni, Kim, Sol Ji, Chung, Wookyung, Jung, Ji Yong, Jin, Kwon Eun, Sung, Suah, Min, Hyang Ki, Ku, Ja Yung, Kim, Soo Wan, Kwon, Seong, Bae, Eun Hui, Kim, Chang Seong, Kim, Ha Yeon, Oh, Tae Ryom, Choi, Hong Sang, Kim, Minah, Myeong, Chana, Lee, Jeong Ho, Lee, Ji Seon, Kim, Yeong Hoon, Kang, Sun Woo, Kim, Tae Hee, Kim, Yunmi, Oh, Young Eun, Koo, Ja Ryong, Seo, Jang Won, Baek, Seon Ha, Kim, Myung Sun, Chang, Tae Ik, Park, Kyoung Sook, Choi, Aei Kyung, Oh, Yun Kyu, Lee, Jung Pyo, Lee, Jeong Hwan, Park, Jeong Mi, Seong, Eun Young, Heon, Song Sang, Rhee, Harin, Kim, Hyo Jin, Woon, Kim Da, Ji, Seung Hee, Kim, Young Taek, Na, Ki Ryang, Choi, Dae Eun, Ham, Young Rok, Lee, Eu Jin, and Cha, Yoon Jung

Published
2022
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19. Proteinuria, measured or estimated albuminuria for risk prediction in patients with chronic kidney disease?

Author

Kim, Hyoungnae, Hyun, Young Youl, Joo, Young Su, Yun, Hae-Ryong, Kim, Yaeni, Jung, Ji Yong, Jeong, Jong Cheol, Kim, Jayoun, Park, Jung Tak, Yoo, Tae-Hyun, Kang, Shin-Wook, Oh, Kook-Hwan, and Han, Seung Hyeok

Subjects
CHRONIC kidney failure, ALBUMINURIA, PROTEINURIA, CHRONICALLY ill, KIDNEY failure
Abstract

Background Although albuminuria is the gold standard for defining chronic kidney disease (CKD), total proteinuria has also been widely used in real-world clinical practice. Moreover, the superiority of the prognostic performance of albuminuria over proteinuria in patients with CKD remains inconclusive. Therefore, we aimed to compare the predictive performances of albuminuria and proteinuria in these patients. Methods From the Korean Cohort Study for Outcome in Patients with CKD we included 2099 patients diagnosed with CKD grades 1–5 who did not require kidney replacement therapy. We measured the spot urine albumin:creatinine ratio (mACR) and protein:creatinine ratio (PCR) and estimated the ACR (eACR) using the PCR. Kidney failure risk equation (KFRE) scores were calculated using the mACR, PCR and eACR. The primary outcome was the 5-year risk of kidney failure with replacement therapy (KFRT). Results The eACR significantly underestimated mACR in patients with low albuminuria levels. The time-dependent area under the receiver operating characteristics curve showed excellent predictive performance for all KFRE scores from the mACR, PCR and eACR. However, eACR was inferior to mACR based on the continuous net reclassification index (cNRI) and integrated discrimination improvement index (IDI) in all CKD cause groups, except for the group with an unclassified aetiology. Moreover, the cNRI and IDI statistics indicated that both eACR and PCR were inferior to mACR in patients with low albuminuria (<30 mg/g). Conversely, the predictive performance of PCR was superior in severe albuminuria and nephrotic-range proteinuria, in which the IDI and cNRI of the PCR were greater than those of the mACR. Conclusions The mACR, eACR and PCR showed excellent performance in predicting KFRT in patients with CKD. However, eACR was inferior to mACR in patients with low albuminuria, indicating that measuring rather than estimating albuminuria is preferred for these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Proteinuria, measured or estimated albuminuria for risk prediction in patients with chronic kidney disease?

Author

Kim, Hyoungnae, primary, Hyun, Young Youl, additional, Joo, Young Su, additional, Yun, Hae-Ryong, additional, Kim, Yaeni, additional, Jung, Ji Yong, additional, Jeong, Jong Cheol, additional, Kim, Jayoun, additional, Park, Jung Tak, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, Oh, Kook-Hwan, additional, and Han, Seung Hyeok, additional

Published
2023
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27. Association of coronary artery calcium with adverse cardiovascular outcomes and death in patients with chronic kidney disease: results from the KNOW-CKD

Author

Jung, Chan-Young, primary, Yun, Hae-Ryong, additional, Park, Jung Tak, additional, Joo, Young Su, additional, Kim, Hyung Woo, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, Lee, Joongyub, additional, Chae, Dong-Wan, additional, Chung, Wookyung, additional, Kim, Yong-Soo, additional, Oh, Kook-Hwan, additional, and Han, Seung Hyeok, additional

Published
2022
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28. Association of coronary artery calcium with adverse cardiovascular outcomes and death in patients with chronic kidney disease: results from the KNOW-CKD.

Author

Jung, Chan-Young, Yun, Hae-Ryong, Park, Jung Tak, Joo, Young Su, Kim, Hyung Woo, Yoo, Tae-Hyun, Kang, Shin-Wook, Lee, Joongyub, Chae, Dong-Wan, Chung, Wookyung, Kim, Yong-Soo, Oh, Kook-Hwan, and Han, Seung Hyeok

Subjects
CORONARY artery calcification, CHRONIC kidney failure, CARDIOVASCULAR disease related mortality, CHRONICALLY ill, MAJOR adverse cardiovascular events
Abstract

Background In East Asian countries, patients with chronic kidney disease (CKD) have lower cardiovascular risk profiles and experience fewer cardiovascular events (CVEs) than those in Western countries. Thus the clinical predictive performance of well-known risk factors warrants further testing in this population. Methods The KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD) is a multicenter, prospective observational study. We included 1579 participants with CKD G1–G5 without kidney replacement therapy between 2011 and 2016. The main predictor was the coronary artery calcium score (CACS). The primary outcome was a composite of nonfatal CVEs or all-cause mortality. Secondary outcomes included 3-point major adverse cardiovascular events (MACEs; the composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke), all CVEs and all-cause mortality. Results During a median follow-up of 5.1 years, a total of 123 primary outcome events occurred (incidence rate 1.6/100 person-years). In the multivariable Cox model, a 1-standard deviation log increase in the CACS was associated with a 1.67-fold [95% confidence interval (CI), 1.37–2.04] higher risk of the primary outcome. Compared with a CACS of 0, the hazard ratio associated with a CACS >400 was 4.89 (95% CI 2.68–8.93) for the primary outcome. This association was consistent for secondary outcomes. Moreover, inclusion of the CACS led to modest improvements in prediction indices of the primary outcome compared with well-known conventional risk factors. Conclusions In Korean patients with CKD, the CACS was independently associated with adverse cardiovascular outcomes and all-cause death. The CACS also showed modest improvements in prediction performance over conventional cardiovascular risk factors. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Low-density lipoprotein cholesterol levels and adverse clinical outcomes in chronic kidney disease: Results from the KNOW-CKD

Author

Lee, Changhyun, primary, Park, Jung Tak, additional, Chang, Tae-Ik, additional, Kang, Ea Wha, additional, Nam, Ki Heon, additional, Joo, Young Su, additional, Sung, Su-Ah, additional, Kim, Yeong Hoon, additional, Chae, Dong-Wan, additional, Park, Su Kyung, additional, Ahn, Curie, additional, Oh, Kook-Hwan, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, and Han, Seung Hyeok, additional

Published
2022
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33. Erythropoiesis stimulating agent recommendation model using recurrent neural networks for patient with kidney failure with replacement therapy

Author

Yun, Hae-Ryong, primary, Lee, Gyubok, additional, Jeon, Myeong Jun, additional, Kim, Hyung Woo, additional, Joo, Young Su, additional, Kim, Hyoungnae, additional, Chang, Tae Ik, additional, Park, Jung Tak, additional, Han, Seung Hyeok, additional, Kang, Shin-Wook, additional, Kim, Wooju, additional, and Yoo, Tae-Hyun, additional

Published
2021
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35. Synergic association of diabetes mellitus and chronic kidney disease with muscle loss and cachexia: results of a 16-year longitudinal follow-up of a community-based prospective cohort study

Author

Lee, Changhyun, primary, Kim, Hyun Jung, additional, Chang, Tae Ik, additional, Kang, Ea Wha, additional, Joo, Young Su, additional, Kim, Hyung Woo, additional, Park, Jung Tak, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, and Han, Seung Hyeok, additional

Published
2021
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36. Association of blood pressure with cardiovascular outcome and mortality: results from the KNOW-CKD study

Author

Lee, Jee Young, primary, Park, Jung Tak, additional, Joo, Young Su, additional, Lee, Changhyun, additional, Yun, Hae-Ryong, additional, Chang, Tae Ik, additional, Kim, Yeong-Hoon, additional, Chung, WooKyung, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, Park, Sue K, additional, Chae, Dong Wan, additional, Oh, Kook-Hwan, additional, and Han, Seung Hyeok, additional

Published
2021
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37. Association of blood pressure with cardiovascular outcome and mortality: results from the KNOW-CKD study.

Author

Lee, Jee Young, Park, Jung Tak, Joo, Young Su, Lee, Changhyun, Yun, Hae-Ryong, Chang, Tae Ik, Kim, Yeong-Hoon, Chung, WooKyung, Yoo, Tae-Hyun, Kang, Shin-Wook, Park, Sue K, Chae, Dong Wan, Oh, Kook-Hwan, and Han, Seung Hyeok

Subjects
BLOOD pressure, STATISTICAL models, CHRONIC kidney failure, KOREANS, CHRONICALLY ill
Abstract

Background Optimal blood pressure (BP) control is a major therapeutic strategy to reduce adverse cardiovascular events (CVEs) and mortality in patients with chronic kidney disease (CKD). We studied the association of BP with adverse cardiovascular outcome and all-cause death in patients with CKD. Methods Among 2238 participants from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD), 2226 patients with baseline BP measurements were enrolled. The main predictor was systolic BP (SBP) categorized by five levels: <110, 110–119, 120–129, 130–139 and ≥140 mmHg. The primary endpoint was a composite outcome of all-cause death or incident CVEs. We primarily used marginal structural models (MSMs) using averaged and the most recent time-updated SBPs. Results During the follow-up of 10 233.79 person-years (median 4.60 years), the primary composite outcome occurred in 240 (10.8%) participants, with a corresponding incidence rate of 23.5 [95% confidence interval (CI) 20.7–26.6]/1000 patient-years. MSMs with averaged SBP showed a U-shaped relationship with the primary outcome. Compared with time-updated SBP of 110–119 mmHg, hazard ratios (95% CI) for <110, 120–129, 130–139 and ≥140 mmHg were 2.47 (1.48–4.11), 1.29 (0.80–2.08), 2.15 (1.26–3.69) and 2.19 (1.19–4.01), respectively. MSMs with the most recent SBP also showed similar findings. Conclusions In Korean patients with CKD, there was a U-shaped association of SBP with the risk of adverse clinical outcomes. Our findings highlight the importance of BP control and suggest a potential hazard of SBP <110 mmHg. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Association of Blood Pressure With the Progression of CKD: Findings From KNOW-CKD Study

Author

Lee, Jee Young, primary, Park, Jung Tak, additional, Joo, Young Su, additional, Lee, Changhyun, additional, Yun, Hae-Ryong, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, Choi, Kyu Hun, additional, Ahn, Curie, additional, Oh, Kook-Hwan, additional, Sung, Suah, additional, Kim, Soo Wan, additional, Lee, Joongyub, additional, Han, Seung Hyeok, additional, Chae, Dong Wan, additional, Chin, Ho Jun, additional, Lee, Sung Woo, additional, Lee, Kyubeck, additional, Hyun, Young Youl, additional, Ma, Seong Kwon, additional, Bae, Eun Hui, additional, Kim, Chang Seong, additional, Kim, Yong-Soo, additional, Chung, Wookyung, additional, Jung, Ji Young, additional, Kim, Yeong Hoon, additional, Kim, Tae Hee, additional, Kang, Sun Woo, additional, Oh, Yun Kyu, additional, and Park, Sue K., additional

Published
2021
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39. Smoking Cessation and Coronary Artery Calcification in CKD

Author

Lee, Mi Jung, primary, Park, Jung Tak, additional, Chang, Tae Ik, additional, Joo, Young Su, additional, Yoo, Tae-Hyun, additional, Park, Sue Kyung, additional, Chung, Wookyung, additional, Kim, Yong-Soo, additional, Kim, Soo Wan, additional, Oh, Kook-Hwan, additional, Kang, Shin-Wook, additional, Choi, Kyu Hun, additional, Ahn, Curie, additional, and Han, Seung Hyeok, additional

Published
2021
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40. Association Between Systolic Blood Pressure Variability and Major Adverse Cardiovascular Events in Korean Patients With Chronic Kidney Disease: Findings From KNOW-CKD.

Author

Cheol Ho Park, Hyung Woo Kim, Young Su Joo, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Sue Kyung Park, Dong-Wan Chae, Wookyung Chung, Yong-Soo Kim, Kook-Hwan Oh, Shin-Wook Kang, Seung Hyeok Han, Park, Cheol Ho, Kim, Hyung Woo, Joo, Young Su, Park, Jung Tak, Chang, Tae Ik, Yoo, Tae-Hyun, and Park, Sue Kyung

Published
2022
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42. Dietary zinc intake and incident chronic kidney disease

Author

Joo, Young Su, primary, Kim, Hyung Woo, additional, Lee, Sangmi, additional, Nam, Ki Heon, additional, Yun, Hae-Ryong, additional, Jhee, Jong Hyun, additional, Han, Seung Hyeok, additional, Yoo, Tae-Hyun, additional, Kang, Shin-Wook, additional, and Park, Jung Tak, additional

Published
2021
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45. Low High‐Sensitivity C‐Reactive Protein Level in Korean Patients With Chronic Kidney Disease and Its Predictive Significance for Cardiovascular Events, Mortality, and Adverse Kidney Outcomes: Results From KNOW‐CKD

Author

Lee, Changhyun, primary, Park, Keun Hyung, additional, Joo, Young Su, additional, Nam, Ki Heon, additional, Chang, Tae‐Ik, additional, Kang, Ea Wha, additional, Lee, Joongyub, additional, Oh, Yun Kyu, additional, Jung, Ji Yong, additional, Ahn, Curie, additional, Lee, Kyu‐Beck, additional, Park, Jung Tak, additional, Yoo, Tae‐Hyun, additional, Kang, Shin‐Wook, additional, and Han, Seung Hyeok, additional

Published
2020
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47. Body weight fluctuation is associated with rapid kidney function decline.

Author

Joo, Young Su, Nam, Ki Heon, Jhee, Jong Hyun, Yun, Hae‐Ryong, Lee, Sangmi, Han, Seung Hyeok, Yoo, Tae‐Hyun, Kang, Shin‐Wook, and Park, Jung Tak

Subjects
KIDNEY physiology, BODY weight, GLOMERULAR filtration rate, EPIDERMAL growth factor receptors
Abstract

Objective: This study aimed to evaluate the effects of body weight fluctuations on kidney function deterioration in a prospective cohort of individuals with normal kidney function. Methods: Data were obtained from the Korean Genome and Epidemiology Study. Body weight fluctuations were determined using average successive variability (ASV), which was defined as the average absolute body weight change using repeated measurements for all participants. The decline of the estimated glomerular filtration rate (eGFR) over time was calculated using linear regression analysis of serial eGFR measurements for each patient. Rapid eGFR decline was defined as an average eGFR decline > 3 mL/min/1.73 m2 per year. Results: A total of 6,790 participants were analyzed. During a median follow‐up of 11.7 years, rapid eGFR decline was observed in 913 (13.4%) participants. When the participants were categorized into tertiles according to ASV, rapid eGFR decline was more prevalent in the highest ASV tertile group than in the lowest. Analyses using multiple logistic regression models revealed that the risk of rapid eGFR decline was increased in the highest ASV tertile group compared with the lowest (odds ratio: 1.66). Conclusions: Body weight fluctuations were significantly associated with an increased risk of rapid kidney function decline in participants with normal kidney function. [ABSTRACT FROM AUTHOR]

Published
2022
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50. P0926ASSOCIATION OF HIGH-SENSITIVE C-REACTIVE PROTEIN WITH CARDIOVASCULAR EVENTS, MORTALITY, AND ADVERSE KIDNEY OUTCOMES IN KOREAN PATIENTS WITH CHRONIC KIDNEY DISEASE: RESULTS FROM KNOW-CKD

Author

Lee, Changhyun, primary, Park, Keun Hyung, primary, Joo, Young Su, primary, Nam, Ki Heon, primary, Chang, Tae-Ik, primary, Kang, Ea Wha, primary, Lee, Joongyub, primary, Oh, Yun Kyu, primary, Jung, Ji Yong, primary, Ahn, Curie, primary, Lee, Kyu-Beck, primary, Park, Jung Tak, primary, Yoo, Tae-Hyun, primary, Kang, Shin-Wook, primary, and Han, Seung Hyeok, primary

Published
2020
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