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3. Genome-wide association study and polygenic risk score analysis for schizophrenia in a Korean population

Author

Lee, Dongbin, Baek, Ji Hyun, Kim, Yujin, Lee, Byung Dae, Cho, Eun-Young, Joo, Eun-Jeong, Ahn, Yong Min, Kim, Se Hyun, Chung, Young-Chul, Rami, Fatima Zahra, Kim, Se Joo, Kim, Sung-Wan, Myung, Woojae, Ha, Tae Hyon, Lee, Heon-Jeong, Oh, Hayoung, Lee, Kyu Young, Kim, Min Ji, Kang, Chae Yeong, Jeon, Sumoa, Jo, Anna, Yu, Hyeona, Jeong, Seunghwa, Ha, Kyooseob, Kim, Beomsu, Shim, Injeong, Cho, Chamlee, Huang, Hailiang, Won, Hong-Hee, and Hong, Kyung Sue

Published
2024
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6. Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Author

Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Jr., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C.K., Chan, Ronald Y.L., Chen, Eric Y.H., Cheng, Wei, Cheung, Eric FC., Chong, Siow Ann, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, Del Favero, Jurgen, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farrell, Martilias S., Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Lee, Jimmy, Lee, S. Hong, Legge, Sophie E., Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Magnusson, Patrik K.E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Mors, Ole, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, O'Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon-Cheong, Spencer, Chris C.A., Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Stroup, T Scott, Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H.M., Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H.R., Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Cichon, Sven, Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mortensen, Preben B., Mowry, Bryan J., Nöthen, Markus M., Ophoff, Roel A., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Rietschel, Marcella, Riley, Brien P., Rujescu, Dan, Sham, Pak C., Sklar, Pamela, St Clair, David, Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., Sullivan, Patrick F., O'Donovan, Michael C., Qin, Shengying, Sawa, Akira, Kahn, Rene, Hong, Kyung Sue, Shi, Wenzhao, Tsuang, Ming, Itokawa, Masanari, Feng, Gang, Glatt, Stephen J., Ma, Xiancang, Tang, Jinsong, Ruan, Yunfeng, Liu, Ruize, Zhu, Feng, Horiuchi, Yasue, Lee, Byung Dae, Joo, Eun-Jeong, Myung, Woojae, Ha, Kyooseob, Won, Hong-Hee, Baek, Ji Hyung, Chung, Young Chul, Kim, Sung-Wan, Kusumawardhani, Agung, Chen, Wei J., Hwu, Hai-Gwo, Hishimoto, Akitoyo, Otsuka, Ikuo, Sora, Ichiro, Toyota, Tomoko, Yoshikawa, Takeo, Kunugi, Hiroshi, Hattori, Kotaro, Ishiwata, Sayuri, Numata, Shusuke, Ohmori, Tetsuro, Arai, Makoto, Ozeki, Yuji, Fujii, Kumiko, Kim, Se Joo, Lee, Heon-Jeong, Ahn, Yong Min, Kim, Se Hyun, Akiyama, Kazufumi, Shimoda, Kazutaka, Kinoshita, Makoto, Hsu, Yu-Han H., Pintacuda, Greta, Nacu, Eugeniu, Kim, April, Tsafou, Kalliopi, Petrossian, Natalie, Crotty, William, Suh, Jung Min, Riseman, Jackson, Martin, Jacqueline M., Biagini, Julia C., Mena, Daya, Ching, Joshua K.T., Malolepsza, Edyta, Li, Taibo, Singh, Tarjinder, Ge, Tian, Egri, Shawn B., Tanenbaum, Benjamin, Stanclift, Caroline R., Apffel, Annie M., Carr, Steven A., Schenone, Monica, Jaffe, Jake, Fornelos, Nadine, Eggan, Kevin C., and Lage, Kasper

Published
2023
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7. Body mass index and prevalence of metabolic syndrome among Korean adults before and after the COVID-19 outbreak: a retrospective longitudinal study

Author

Joo-Eun Jeong, Hoon-Ki Park, Hwan-Sik Hwang, Kye-Yeung Park, Myoung-Hye Lee, Seon-Hi Shin, and Nayeon Choi

Subjects
covid-19, pandemics, metabolic syndrome, body mass index, public health, Medicine
Abstract

OBJECTIVES Studies evaluating weight changes during the coronavirus disease 2019 (COVID-19) pandemic have yielded inconsistent results, and most of those studies were based on self-reported anthropometric measures. We investigated changes in body mass index (BMI), professionally measured waist circumference (WC), and metabolic syndrome components from before to during the pandemic in a sample of the adult population in Korea. METHODS This retrospective study included 1,118 male and female (age≥18 years) who underwent health checkups at a university medical center between January 1, 2016 and March 31, 2022. Changes in BMI, lifestyles, and metabolic syndrome components during the pandemic were analyzed using the paired t-test, McNemar test, generalized estimating equations, and repeated-measures analysis of variance. RESULTS Changes in body weight, BMI, and body fat percentage during the pandemic were not clinically significant. However, statistically significant results were found for decreased physical activity (p

Published
2023
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10. HLA-DPB1 *05:01 and HLA-A *11:01 Is Associated with Adverse Drug Reactions to Isoniazid and Rifampin for Treatment of Latent Tuberculosis Infection in South Korea.

Author

Kim, Bomi, Kim, Jungok, Yoon, Sun-Young, Cheong, Hae Suk, Kwon, Min-Jung, Yeom, Joon-Sup, Kim, Han-Na, and Joo, Eun-Jeong

Subjects
LATENT tuberculosis, DRUG side effects, MEDICAL personnel, ISONIAZID, HLA histocompatibility antigens
Abstract

Background: Screening and treating healthcare workers (HCWs) for latent tuberculosis infection (LTBI) are essential for tuberculosis (TB) infection control. Adverse drug reactions (ADRs) to anti-TB drugs present challenges to patient safety and treatment completion. Objective: This study investigated the association between human leukocyte antigen (HLA) alleles and the risk of ADRs, especially drug hypersensitivity (DHS) and hepatotoxicity, in HCWs with LTBI receiving isoniazid (INH) and rifampin (RIF) therapy. Methods: Korean HCWs with LTBI who received a 3 month INH and RIF regimen were included in this study. HLA genotyping was performed on HCWs who experienced ADRs during treatment, as well as the control group consisted of individuals who did not develop ADRs. Results: Of the 67 patients, 29 (43.2%) experienced ADRs during INH and RIF therapy. The HLA-A*11:01 allele was more frequent in patients with DHS without hepatotoxicity (DSH+/H−) compared to the control group (DHS−/H−) (4/9, 44.4% vs. 3/38, 7.9%; odd ratio [OR], 8.554; 95% confidence interval [CI], 1.415–59.869; p = 0.018). Conversely, HLA-DPB1*05:01 was associated with an increased risk of hepatotoxicity regardless of DHS (10/20, 50% vs. 5/38, 13.2%; OR, 5.323; 95% CI, 1.493–21.518; p = 0.011). In the DHS with hepatotoxicity group (DHS+/H+), HLA-DPB1*05:01 was present in a higher proportion (3/5, 60% vs. 5/38, 13.2%; OR, 8.912; 95% CI, 1.110–92.993; p = 0.037), whereas HLA-A*11:01 was not observed in this group. Conclusions: The HLA-A*11:01 allele was associated with an increased risk of DHS without hepatotoxicity, whereas the HLA-DPB1*05:01 allele was associated with an increased risk of hepatotoxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Evaluation of a Nondepleted Plasma Multiprotein-Based Model for Discriminating Psychiatric Disorders Using Multiple Reaction Monitoring-Mass Spectrometry: Proof-of-Concept Study

Author

Shin, Dongyoon, primary, Lee, Jihyeon, additional, Kim, Yeongshin, additional, Park, Junho, additional, Shin, Daun, additional, Song, Yoojin, additional, Joo, Eun-Jeong, additional, Roh, Sungwon, additional, Lee, Kyu Young, additional, Oh, Sanghoon, additional, Ahn, Yong Min, additional, Rhee, Sang Jin, additional, and Kim, Youngsoo, additional

Published
2023
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25. Serum Protein Profiling Reveals a Decrease in Apolipoprotein A-IV During a Clinical Depressive Mood State

Author

Mun,Sora, Lee,Seungyeon, Yun,Yeeun, Joo,Eun-Jeong, Kang,Hee-Gyoo, Lee,Jiyeong, Mun,Sora, Lee,Seungyeon, Yun,Yeeun, Joo,Eun-Jeong, Kang,Hee-Gyoo, and Lee,Jiyeong

Abstract

Sora Mun,1 Seungyeon Lee,2 Yeeun Yun,3 Eun-Jeong Joo,4,5 Hee-Gyoo Kang,1– 3 Jiyeong Lee1,3 1Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, Gyeonggi, Republic of Korea; 2Department of Senior Healthcare, Graduate School, Eulji University, Gyeonggi, Republic of Korea; 3Department of Biomedical Laboratory Science, Graduate School, Eulji University, Gyeonggi, Republic of Korea; 4Department of Neuropsychiatry, School of Medicine, Eulji University, Daejeon, Republic of Korea; 5Department of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University, Gyeonggi, Republic of KoreaCorrespondence: Hee-Gyoo Kang, Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, 553 Sanseong-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea, Tel +82-31-740-7315, Email kanghg@eulji.ac.kr Jiyeong Lee, Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, 712 Dongil-ro, Uijeongbu-si, Gyeonggi-do, Republic of Korea, Tel +82-31-951-3862, Email leejiyeong@eulji.ac.krPurpose: Depressive mood is a major psychiatric symptom that causes serious disturbances in daily life. Unlike physical symptoms, psychiatric symptoms are more difficult to evaluate objectively. Therefore, we aimed to discover biomarkers that reflect changes in serum protein metabolism during a clinical depressive mood.Methods: Serum protein profiling was conducted in participants who were not experiencing a current depressive episode (healthy individuals and patients in remission). Serum proteins were identified and quantified using liquid chromatography–tandem mass spectrometry. Differentially expressed proteins with a p-value < 0.05 were selected, and candidate biomarkers were verified using multiple reaction monitoring analysis for absolute quantification.Results: Apolipoprotein A-IV levels were lower in the group with a current episode of depression than in the remission and healthy control gro

Published
2023

37. Integrating proteomic and clinical data to discriminate major psychiatric disorders: Applications for major depressive disorder, bipolar disorder, and schizophrenia

Author

Shin, Dongyoon, primary, Rhee, Sang Jin, additional, Shin, Daun, additional, Joo, Eun‐Jeong, additional, Jung, Hee Yeon, additional, Roh, Sungwon, additional, Lee, Sang‐Hyuk, additional, Kim, Hyeyoung, additional, Bang, Minji, additional, Lee, Kyu Young, additional, Kim, Se Hyun, additional, Lee, Jihyeon, additional, Kim, Yoseop, additional, Yeo, Injoon, additional, Kim, Yeongshin, additional, Kim, Jaenyeon, additional, Kwon, Jun Soo, additional, Ha, Kyooseob, additional, Ahn, Yong Min, additional, and Kim, Youngsoo, additional

Published
2022
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45. Estimating the Neutralizing Effect and Titer Correlation of Semi-Quantitative Anti-SARS-CoV-2 Antibody Immunoassays

Author

Lee, Beomki, primary, Ko, Jae-Hoon, additional, Park, Jiho, additional, Moon, Hee-Won, additional, Baek, Jin Yang, additional, Jung, Sunhee, additional, Lim, Hee-Young, additional, Kim, Kyung-Chang, additional, Huh, Kyungmin, additional, Cho, Sun Young, additional, Kang, Cheol-In, additional, Chung, Doo Ryeon, additional, Huh, Hee Jae, additional, Chung, Chi Ryang, additional, Kim, Yae-Jean, additional, Joo, Eun-Jeong, additional, Kang, Eun-Suk, additional, and Peck, Kyong Ran, additional

Published
2022
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46. Clinical Effectiveness of Intravenous Peramivir versus Oseltamivir for the Treatment of Influenza in Hospitalized Patients

Author

Lee, Jin Seo, Lee, Mi Suk, Park, Yoonseon, Lee, Jacob, Joo, Eun-Jeong, and Eom, Joong Sik

Subjects
Infection and Drug Resistance, oseltamivir, intravenous, therapeutics, human, influenza, administration, Original Research
Abstract

Jin Seo Lee,1 Mi Suk Lee,2 Yoonseon Park,3 Jacob Lee,4 Eun-Jeong Joo,5 Joong Sik Eom6 1Division of Infectious Disease, Department of Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea; 2Division of Infectious Diseases, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Republic of Korea; 3Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Republic of Korea; 4Division of Infectious Diseases, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea; 5Division of Infectious Diseases, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 6Division of Infectious Diseases, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of KoreaCorrespondence: Joong Sik Eom Tel +82-32-460-3741Fax +82-2-488-0119Email helppl@gachon.ac.krPurpose: To compare the clinical efficacy between peramivir and oseltamivir in hospitalized patients with influenza.Patients and Methods: Retrospective cohort study examined data from 542 adult patients with laboratory-confirmed seasonal influenza hospitalized in five teaching hospitals and one secondary hospital between August 2017 and May 2018. The main outcome was the defervescence rate within 3 days from the first administration of peramivir or oseltamivir. The secondary outcomes were mortality and duration of hospitalization/intensive care unit (ICU) stay.Results: Of the 542 enrolled patients, 251 were administered the standard dose of peramivir (300 mg, single dose), 42 were administered peramivir at doses exceeding 300 mg, and 249 were administered oseltamivir (75 mg, twice daily for 5 days). There were more ICU and pneumonia cases and older patients in the peramivir group, especially the high-dose group. The Charlson comorbidity index (CCI) scores were similar among the three groups. There were no significant differences in defervescence rates within 3 days between the three groups. The mortality and duration of hospital and ICU stays also did not differ significantly. The factors associated with 30-day mortality were ICU admission, high CCI score, and pneumonia.Conclusion: Treatment of influenza with either peramivir or oseltamivir in hospitalized adults resulted in generally similar clinical outcomes. Peramivir treatment showed good clinical response in influenza patients with pneumonia or admitted to the ICU.Keywords: influenza, human, therapeutics, oseltamivir, administration, intravenous

Published
2020

48. Development and Roll-Out of A Coronavirus Disease 2019 Clinical Pathway for Standardized Qualified Care in Public Hospitals in Korea

Author

Kwak, Mi Young, primary, Jo, Eun Young, additional, Chin, BumSik, additional, Park, Se Eun, additional, Yim, Jun, additional, Lee, Jung Eun, additional, Jo, Kyung Eun, additional, Kim, Yeon-Sook, additional, Lee, Jeong Eun, additional, Yoon, Young Kyung, additional, Seo, Yu Bin, additional, Jeong, Su Jin, additional, Kang, Yu Min, additional, Joo, Eun-Jeong, additional, Yoon, Jong Hyun, additional, Kim, Sun Bean, additional, Kim, Ga Yeon, additional, and Kim, Min-Kyung, additional

Published
2022
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49. Clinical Characteristics and Risk Factors for Mortality in Critical Coronavirus Disease 2019 Patients 50 Years of Age or Younger During the Delta Wave: Comparison With Patients > 50 Years in Korea

Author

Shi, Hye Jin, primary, Nham, Eliel, additional, Kim, Bomi, additional, Joo, Eun-Jeong, additional, Cheong, Hae Suk, additional, Hong, Shin Hee, additional, Hyun, Miri, additional, Kim, Hyun ah, additional, Jang, Sukbin, additional, Rhee, Ji-Young, additional, Kim, Jungok, additional, Kim, Sungmin, additional, Cho, Hyun Kyu, additional, Wi, Yu Mi, additional, Cheon, Shinhye, additional, Kim, Yeon-Sook, additional, Lim, Seungjin, additional, Seok, Hyeri, additional, Jung, Sook In, additional, Eom, Joong Sik, additional, and Peck, Kyong Ran, additional

Published
2022
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50. Risk Factors for Coronavirus Disease 2019 (COVID-19)-Associated Pulmonary Aspergillosis in Critically Ill Patients: A Nationwide, Multicenter, Retrospective Cohort Study

Author

Kim, Si-Ho, primary, Hong, Jin Yeong, additional, Bae, Seongman, additional, Lee, Hojin, additional, Wi, Yu Mi, additional, Ko, Jae-Hoon, additional, Kim, Bomi, additional, Joo, Eun-Jeong, additional, Seok, Hyeri, additional, Shi, Hye Jin, additional, Yoo, Jeong Rae, additional, Hyun, Miri, additional, Kim, Hyun ah, additional, Jang, Sukbin, additional, Mun, Seok Jun, additional, Kim, Jungok, additional, Kim, Min-Chul, additional, Jung, Dong-Sik, additional, Kim, Sung-Han, additional, and Peck, Kyong Ran, additional

Published
2022
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