Search

Your search keyword '"Jonker, A.M."' showing total 17 results
Start Over Author "Jonker, A.M."
17 results on '"Jonker, A.M."'

Catalog

Books, media, physical & digital resources
See catalog results

3. Bio-inspired cross-linking methods for hydrogel formation

Author

Jonker, A.M., Hest, J.C.M. van, Lowik, D.W.P.M., and Radboud University Nijmegen

Subjects
Bio-Organic Chemistry, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 150248.pdf (Publisher’s version ) (Open Access) Radboud Universiteit Nijmegen, 20 januari 2016 Promotor : Hest, J.C.M. van Co-promotor : Lowik, D.W.P.M. 223 p.

Published
2016

4. Bio-inspired cross-linking methods for hydrogel formation

Author

Hest, J.C.M. van, Lowik, D.W.P.M., Jonker, A.M., Hest, J.C.M. van, Lowik, D.W.P.M., and Jonker, A.M.

Abstract

Radboud Universiteit Nijmegen, 20 januari 2016, Promotor : Hest, J.C.M. van Co-promotor : Lowik, D.W.P.M., Contains fulltext : 150248.pdf (publisher's version ) (Open Access)

Published
2016

6. Isolated hepatic perfusion in the pig with TNF-alpha with and without melphalan

Author

Rinkes, M.J., Vries, M.R. de, Jonker, A.M, Swaak, A.J.G., Hack, C.E., Nooijen, P.T.G.A., Wiggers, T., and Eggermont, A.M.M.

Subjects
The effects of tumor necrosis factor on the tumor vasculature, De effecten van tumor necrose factor op het tumorvaatbed, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 26146.PDF (Publisher’s version ) (Open Access)

Published
1997

9. A fast and activatable cross-linking strategy for hydrogel formation

Author

Jonker, A.M., Borrmann, A., Eck, E.R.H. van, Delft, F.L. van, Lowik, D.W.P.M., Hest, J.C.M. van, Jonker, A.M., Borrmann, A., Eck, E.R.H. van, Delft, F.L. van, Lowik, D.W.P.M., and Hest, J.C.M. van

Abstract

Contains fulltext : 140104.pdf (publisher's version ) (Closed access)

Published
2015

13. Physicochemical properties and applications of poly(lactic-co-glycolic acid) for use in bone regeneration

Author

Lanao, R.P., Jonker, A.M., Wolke, J.G.C., Jansen, J.A., Hest, J.C.M. van, Leeuwenburgh, S.C.G., Lanao, R.P., Jonker, A.M., Wolke, J.G.C., Jansen, J.A., Hest, J.C.M. van, and Leeuwenburgh, S.C.G.

Abstract

Item does not contain fulltext, Poly(lactic-co-glycolic acid) (PLGA) is the most often used synthetic polymer within the field of bone regeneration owing to its biocompatibility and biodegradability. As a consequence, a large number of medical devices comprising PLGA have been approved for clinical use in humans by the American Food and Drug Administration. As compared with the homopolymers of lactic acid poly(lactic acid) and poly(glycolic acid), the co-polymer PLGA is much more versatile with regard to the control over degradation rate. As a material for bone regeneration, the use of PLGA has been extensively studied for application and is included as either scaffolds, coatings, fibers, or micro- and nanospheres to meet various clinical requirements. more...

Published
2013

14. Peptide- and protein-based hydrogels

Author

Jonker, A.M., Lowik, D.W.P.M., Hest, J.C.M. van, Jonker, A.M., Lowik, D.W.P.M., and Hest, J.C.M. van

Abstract

Contains fulltext : 94001.pdf (publisher's version ) (Closed access)

Published
2012

16. Isolated hepatic perfusion in the pig with TNF-alpha with and without melphalan

Author

Borel Rinkes, I.H.M., Vries, M.R. de, Jonker, A.M., Swaak, A.J.G., Hack, C.E., Nooijen, P.T.G.A., Wiggers, T., Eggermont, A.M.M., Borel Rinkes, I.H.M., Vries, M.R. de, Jonker, A.M., Swaak, A.J.G., Hack, C.E., Nooijen, P.T.G.A., Wiggers, T., and Eggermont, A.M.M. more...

Abstract

Contains fulltext : 26146.PDF (publisher's version ) (Open Access)

Published
1997

17. The chemosensitizer cyclosporin A enhances the toxic side-effects of doxorubicin in the rat

Author

Vrie, W. (Wim) van de, Jonker, A.M. (Ard Mieke), Marquet, R.L. (Richard), Eggermont, A.M.M. (Alexander), Vrie, W. (Wim) van de, Jonker, A.M. (Ard Mieke), Marquet, R.L. (Richard), and Eggermont, A.M.M. (Alexander) more...

Abstract

the feasibility of using chemosensitizers in the circumvention of P-glycoprotein-mediated multidrug resistance has been shown in many studies. We recently reported on the chemosensitizing effect of cyclosporin A (CsA) on doxorubicin in a rat solid tumour model. Using the same experimental design we investigated the side-effects of the combination treatment. During the 35-day experiment doxorubicin treatment caused dose-dependent weight loss, which was enhanced by combination treatment with CsA. The main doxorubicin-related side-effects were myelosuppression (transient leucopenia and thrombopenia) and nephrotoxicity. Damage to the kidney was severe, leading to a nephrotic syndrome and resulting in ascites, pleural effusion, hypercholesterolaemia and hypertriglyceridaemia. These toxicities were enhanced by the addition of the chemosensitizer CsA. Mild doxorubicin-related cardiomyopathy and minimal hepatotoxicity were seen on histological examination. There were no signs of enhanced toxicity of the combination treatment in tissues with known high expression levels of P-glycoprotein, like the liver, adrenal gland and large intestine. CsA had a low toxicity profile, as it only caused a transient rise in bilirubin. In conclusion, the chemosensitizer CsA enhanced the side-effects of the anticancer drug doxorubiein without altering the toxicity pattern. There was no evidence of a therapeutic gain by adding CsA to doxorubicin, compared to single-agent treatment with doxorubicin in 25%-33% higher doses, because of the enhanced toxicity of the combination treatment. more...

Published
1994
Full Text
View/download PDF