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Coronavirus disease 2019 (COVID-19) has become a global pandemic and COVID-19-associated anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis may occur through an immune-mediated pathomechanism.A 21-year-old woman with a history of COVID-19 presented to our hospital with memory decline and psychiatric symptoms.The patient was diagnosed with anti-NMDAR encephalitis.Intravenous methylprednisolone (1 g/day over 5 days) followed by immunoglobulin (0.4 g/kg/day over 5 days) were administered. The patient underwent laparoscopic salpingo-oophorectomy to remove an ovarian teratoma.The patient was discharged with sequelae of short-term memory impairment, without other neuropsychiatric symptoms.Cases of previously reported anti-NMDAR encephalitis with COVID-19 were reviewed and compared with the present case. Clinicians should be aware of the occurrence of anti-NMDAR encephalitis in patients who present with neuropsychiatric complaints during or after exposure to COVID-19. Further studies are required to determine the causal relationship between the 2 diseases and predict the prognosis of anti-NMDAR encephalitis after COVID-19 exposure.

Objective: The traditional thermoplastic aeroplane splint for axillary burn contracture is heavy, uncomfortable, and time consuming and difficult to put on and off. The present study tested the effectiveness of a newly designed multi-axis shoulder abduction splint with an easy-to-change angle. Design: Randomized controlled parallel assessor blinded pilot. Setting: Inpatient rehabilitation center in a general hospital. Subjects: Twenty-four patients with recent (< 30 days) burns around the shoulder joint were randomized into two groups. After two dropouts, 11 patients used the new splint for four weeks and 13 patient were left unsplinted for four weeks. Interventions: The newly designed multi-axis shoulder abduction splint keeps the shoulder abducted at the highest possible angle. Main outcomes: The range of motion of the shoulder joint was measured at 0, 1, 2, 3, and 4 weeks. Active abduction, flexion, and external rotation were measured according to the zero position method by placing the axis of the goniometer ventral to the shoulder joint. Results: Repeated-measure ANOVA revealed that the splint group developed significantly better abduction ( P = 0.020) and flexion ( P = 0.036) over 4 weeks than the non-splint group. ANCOVA using the initial (0 week) angle and Shoulder Burn Depth Index as covariates revealed that the splint group had significantly better abduction than the non-splint group ( P = 0.013). Conclusion: The new multi-axis shoulder abduction splint resulted in a significant improvement in shoulder abduction angle compared to unsplinted patients.

In this paper we proposed multi-directional matching windows combined by multi-dimensional feature vector matching, which uses not only intensity values but also multiple feature values, such as variance, first and second derivative of pixels. Multi-dimensional feature vector matching has the advantage of compensating the drawbacks of area-based stereo matching using one feature value, such as intensity. We define matching cost of a pixel by the minimum value among eight multi-dimensional feature vector distances of the pixels expanded in eight directions having the interval of 45 degrees. As best stereo matches, we determine the two points with the minimum matching cost within the disparity range. In the experiment we used aerial imagery and IKONOS satellite imagery and obtained more accurate matching results than that of conventional matching method.

Herein, we report the effects of geometric morphology of ZnO nanostructures on the extraction efficiency of GaN-based light emitting diodes (LEDs). We performed numerical analysis based on the two-dimensional (2D) finite difference of time domain (FDTD) method that was utilized to calculate the light extraction efficiency of the LEDs. We found that the extraction efficiency of the LED increased upon changing the shape of ZnO nanostructure from nanorods to pencil-likenanorods. The current-voltage characteristics of the LED with ZnO nanorods or pencil-like nanorods were similar to those of the LED that did not contain any ZnO nanostructures. The light output power of the LEDs containing ZnO nanorods or pencil-like nanorods at 100 mA increased additionally to 28% and 39%, respectively, relative to that of the LED that did not contain any ZnO nanostructures. These results confirm that the geometric morphology of the ZnO nanostructure plays an important role in improving the extraction efficiency of the LEDs.

Transparent conducting electrodes are important components of highly efficient ultraviolet light-emitting diodes (UV LEDs). Indium tin oxide (ITO) is commonly used to form a current spreading layer, but its UV-range optical transparency is limited with a low sheet resistance. We demonstrate a simple solution-based coating technique to obtain large-area, highly uniform, and conductive silver-nanowire-based electrodes that exhibit UV-range optical transparency better than that of ITO for the same sheet resistance. The UV LEDs fabricated using this current spreading layer showed improved optical power emission as well as improvement in electrical properties.

a b s t r a c t Objective: To evaluate the effect of burn rehabilitation massage therapy on hypertrophic scar after burn. Method: One hundred and forty-six burn patients with hypertrophic scar(s) were randomly divided into an experimental group and a control group. All patients received standard rehabilitation therapy for hypertrophic scars and 76 patients (massage group) additionally received burn scar rehabilitation massage therapy. Both before and after the treatment, we determined the scores of visual analog scale (VAS) and itching scale and assessed the scar characteristics of thickness, melanin, erythema, transepidermal water loss (TEWL), sebum, and elasticity by using ultrasonography, Mexameter 1 , Tewameter 1 , Sebumeter 1 , and Cutometer 1 , respectively. Results: The scores of both VAS and itching scale decreased significantly in both groups, indicating a significant intragroup difference. With regard to the scar characteristics, the massage group showed a significant decrease after treatment in scar thickness, melanin, erythema, TEWL and a significant intergroup difference. In terms of scar elasticity, a significant intergroup difference was noted in immediate distension and gross skin elasticity, while the massage group significant improvement in skin distensibility, immediate distension, immediate retraction, and delayed distension. Conclusion: Our results suggest that burn rehabilitation massage therapy is effective in improving pain, pruritus, and scar characteristics in hypertrophic scars after burn.

Objective To investigate the effect of extracorporeal shock wave therapy (ESWT) on myofascial pain syndrome (MPS). Method Thirty patients with MPS in trapezius muscle were randomly divided into two groups, ESWT group (n=15), and trigger point injections (TPI)+transcutaneous electrical nerve stimulation (TENS) group (n=15). For a total of 3 weeks, ESWT was undertaken with 1,500 pulse each time at one week interval totaling 4,500 pulse, TPI for once a week totaling three times and TENS for five times a week totaling three weeks. Results The changes in pain threshold (lb/cm2) showed the values of 6.86±1.35 before first therapy, 11.43±0.27 after first therapy, and 12.57±0.72 after third therapy, while TPI+TENS group showed the values of 6.20±1.92 before first therapy, 8.80±0.48 after first therapy, and 9.60±2.19 after third therapy, and the changes between the groups were significantly different (p=0.045). The changes in visual analog scale were estimated to be 6.86±0.90 before first therapy, 2.86±0.90 after first therapy, and 1.86±0.69 after third therapy in case of ESWT group, whereas the figures were estimated to be 7.20±1.30 before first therapy, 4.60±0.55 after first therapy, and 2.80±0.84 after third therapy in case of TPI+TENS group, and the changes between the groups were significantly different (p=0.010). The changes in McGill pain questionnaire (p=0.816) and pain rating scale (p=0.644) between the groups were not significantly different. The changes in neck ROM were also not significantly different between the groups (p>0.05). Conclusion The ESWT in patients with MPS in trapezius muscle are as effective as TPI and TENS for the purpose of pain relief and improving cervical range of motion.

Objective To understand the injury pattern of contact burns from therapeutic physical modalities. Method A retrospective study was done in 864 patients with contact burns who discharged from our hospital from January 2005 to December 2008. The following parameters were compared between patients with contact burns from therapeutic modalities and from other causes: general characteristics, burn extent, cause of burn injury, place of occurrence, burn injury site, treatment methods, prevalence of underlying disease, and length of hospital stay were compared between patients with contact burns. Results Of the 864 subjects, 94 patients were injured from therapeutic modalities. A hot pack (n=51) was the most common type of therapeutic modality causing contact burn followed by moxibustion (n=21), electric heating pad (n=16), and radiant heat (n=4). The lower leg (n=31) was the most common injury site followed by the foot & ankle (n=24), buttock & coccyx (n=9), knee (n=8), trunk (n=8), back (n=6), shoulder (n=4), and arm (n=4). Diabetes mellitus was associated with contact burns from therapeutic modalities; the odds ratio was 3.99. Injuries took place most commonly at home (n=56), followed by the hospital (n=33), and in other places (n=5). Conclusion A hot pack was the most common cause of contact burns from therapeutic modalities, and the lower leg was the most common injury site. Injuries took place most commonly at home. The patients with contact burns from therapeutic modalities showed high correlation to presence of diabetes mellitus. These results would be helpful for the prevention of contact burns due to therapeutic modalities.

The compound (III), named LipidGreen, stains lipid droplets in 3T3L1 pre-adipocyte cell lines and fat deposits in zebrafish.

A new small molecule probe for in vivo lipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.

Objective To assess the effectiveness of modified dynamic metacarpophalangeal joint flexion orthoses for treatment of post-burn hand contractures. Method We enrolled 42 hand burn patients with limited range of motion at the metacarpophalangeal joints in this study. The patients were randomly assigned into either a control or an orthotic group. Both groups received the standard rehabilitation therapy focused on hand therapy; 21 subjects in the orthotic group wore a splint for 3 hours per day for 8 weeks. Hand function was measured by active range of motion, grip strength and other assessment tools. All parameters were estimated using the Mann-Whitney U test at the beginning and the end of the treatment after 8 weeks. Results The 21 subjects that had an orthotic intervention showed significant improvement in the range of motion at 2nd, 3rd, 4th and 5th metacarpophalangeal joints (p0.05). There was a significant difference in the hand function scales between the 2 groups (p

59 Copyright c 2015 The Korean Fracture Society. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Received December 12, 2014 Revised December 24, 2014 Accepted December 24, 2014 Address reprint requests to: Tae-Ho Kim, M.D. Department of Orthopedic Surgery, Sahmyook Medical Center, 82 Mangu-ro, Dongdaemun-gu, Seoul 130-711, Korea Tel: 82-2-2210-3324ᆞFax: 82-2-2212-2673 E-mail: crash1401@naver.com

Objective To investigate the effect of extracorporeal shock wave therapy (ESWT) on painful stump neuroma. Methods Thirty patients with stump neuroma at the distal end of an amputation site were assigned randomly to the ESWT group (n=15) and the transcutaneous electrical nerve stimulation (TENS)+desensitization+pharmacological treatment group (n=15). For 3 weeks, the ESWT group received a weekly session involving 1,500 pulses at 0.10 mJ/mm2, while the control group was treated 10 times each, 40 minutes per day with TENS and desensitization treatment, and daily medication for 3 weeks. ESWT stimulation was given by focusing on the area at the neuroma site clearly identified by ultrasound. Results The changes in the McGill pain questionnaire were 38.8±9.0 prior to treatment and 11.8±3.1 following the treatment. The corresponding values for the control group were 37.2±7.7 and 28.5±10.3. The changes between groups were significantly different (p=0.035). The change in visual analog scale prior to and after treatment was 7.0±1.5 and 2.8±0.8 in the ESWT group, respectively, and 7.2±1.4 and 5.8±2.0 in the control group. These changes between the groups were also significantly different (p=0.010). The outcome in the pain rating scale also showed significant differences between groups (p0.05). Conclusion The study findings imply that ESWT for stump neuroma is superior to conventional therapy.

We have developed LipidGreen2, a second generation small molecule probe for lipid imaging. LipidGreen2 has a better fluorescence signal compared with the previous LipidGreen, and selectively stains neutral lipids in cells and fat deposits in live zebrafish. We also demonstrate the application of LipidGreen2 for detecting fatty liver.