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BACKGROUND: A porous Ti6Al4V implant that is manufactured using selective laser melting (SLM) has broad potential applications in the field of orthopaedic implants. The pore structure of the SLM porous Ti6Al4V implant allows for cell migration and osteogenic differentiation, which is favorable for bone ingrowth and osseointegration. However, it is unclear whether the pore structure and partially melted Ti6Al4V particles on a SLM porous Ti6Al4V implant will increase bacterial adhesion and, perhaps, the risk of implant-related infection. QUESTIONS/PURPOSES: (1) Is there more bacterial adhesion and colonization on SLM porous Ti6Al4V implants than on polished orthopaedic implants? (2) Do partially melted Ti6Al4V particles on SLM porous Ti6Al4V implants reduce human bone mesenchymal stem cells (hBMSCs) adhesion, viability, and activity? METHODS: To determine bacterial adhesion and biofilm formation, we incubated five different Ti6Al4V discs (polished, grit-blasted, plasma-sprayed, particle SLM porous, and nonparticle SLM porous discs) with methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Bacterial coverage on the surface of the five different Ti6Al4V discs were evaluated based on scanning electron microscopy (SEM) images quantitatively. In addition, a spread-plate method was used to quantitatively evaluate the bacterial adhesion on those implants. The biofilm formation was stained with crystal violet and semi-quantitatively determined with a microplate reader. The morphology and adhesion of hBMSCs on the five Ti6Al4V discs were observed with SEM. The cell viability was quantitatively evaluated with a Cell Counting Kit-8 assay. In addition, the osteogenic activity was determined in vitro with a quantitatively alkaline phosphatase activity assay and alizarin-red staining. For semiquantitative analysis, the alizarin-red stained mineralized nodules were dissolved and determined with a microplate reader. RESULTS: The polished discs had the lowest MRSA adhesion (8.3% ± 2.6%) compared with grit-blasted (19.1% ± 3.9%; p = 0.006), plasma-sprayed (38.5% ± 5.3%; p < 0.001), particle (23.1% ± 2.8%; p < 0.001), and nonparticle discs (15.7% ± 2.5%; p = 0.003). Additionally, when comparing the two SLM discs, we found that particle discs had higher bacterial coverage than nonparticle discs (23.1% ± 2.8% versus 15.7% ± 2.5%; p = 0.020). An E. coli analysis showed similar results, with the higher adhesion to particle SLM discs than to nonparticle discs (20.7% ± 4.2% versus 14.4% ± 3.6%; p = 0.011). In addition, on particle SLM porous discs, bacterial colonies were localized around the partially melted Ti6Al4V particles, based on SEM images. After a 7-day incubation period, the cell viability in the particle group (optical density value 0.72 ± 0.05) was lower than that in the nonparticle groups (optical density value: 0.87 ± 0.08; p = 0.003). Alkaline phosphatase activity, as a marker of osteogenic differentiation, was lower in the particle group than in the nonparticle group (1.32 ± 0.12 U/mL versus 1.58 ± 0.09 U/mL; p = 0.012). CONCLUSION: Higher bacterial adhesion was observed on SLM porous discs than on polished discs. The partially melted Ti6Al4V particles on SLM porous discs not only enhanced bacterial adhesion but also inhibited the osteogenic activity of hBMSCs. Postprocessing treatment is necessary to remove partially melted Ti6Al4V particles on an SLM implant before further use. Additional studies are needed to determine whether an SLM porous Ti6Al4V implant increases the risk of implant-related infection in vivo. CLINICAL RELEVANCE: As implants with porous Ti6Al4V made using SLM are being designed, our preliminary findings suggest that postprocessing treatment is needed to remove partially melted Ti6Al4V particles before further use. In addition, the depth of the porous structure of the SLM implant should not exceed the maximum depth of bone ingrowth because the host immune defense cannot prevent bacterial adhesion without integration.

Orthopedic injuries constitute the majority of wounds sustained by U.S. soldiers in recent conflicts. The risk of infection is considerable with fracture fixation devices. In this pilot study, we examined the use of unique bactericidal micron-thin sol-gel films on fracture fixation devices and their ability to prevent and eradicate infections. External fixation was studied with micron-thin sol-gel coated percutaneous pins releasing triclosan and inserted medially into rabbit tibiae. A total of 11 rabbits received percutaneous pins that were either uncoated or sol-gel/triclosan coated. Internal fracture fixation was also studied using sol-gel coated intramedullary (IM) nails releasing vancomycin in the intramedullary tibiae. Six sheep received IM nails that were coated with a sol-gel film that either contained vancomycin or did not contain vancomycin. All animals were challenged with Staphylococcus aureus around the implant. Animals were euthanized at 1 month postoperative. Rabbits receiving triclosan/sol-gel coated percutaneous pins did not show signs of infection. Uncoated percutaneous pins had a significantly higher infection rate. In the sheep study, there were no radiographic signs of osteomyelitis with vancomycin/sol-gel coated IM nails, in contrast to the observations in the control cohort. Hence, the nanostructured sol-gel controlled release technology offers the promise of a reliable and continuous delivery system of bactericidals from orthopedic devices to prevent and treat infection.

This study aims to assess and compare the value of FDG PET with combined In-labeled leukocyte/Tc-sulfur colloid bone marrow (WBC/BM) imaging for diagnosing infection in hip and knee prostheses.In this prospective study, patients with painful hip or knee arthroplasty, who were scheduled to undergo clinical and diagnostic evaluation for prosthesis revision, were included. They have been studied by using FDG PET and WBC/BM scan. This study was institutional review board approved and Health Insurance Portability and Accountability Act compliant. All patients provided written informed consent.A total of 134 hip and 87 knee prostheses, suspected of being either infected or noninfectious loosening, were evaluated. All 221 prostheses underwent FDG PET, whereas both WBC/BM imaging and FDG PET were performed in 88 prostheses. The initial analysis of data from the WBC/BM images demonstrated somewhat suboptimal results compared with those of FDG PET scans on 88 patients. In addition, some patients were not willing to undergo both procedures and therefore participate in this study. Therefore, a decision was made to eliminate WBC/BM imaging from the procedures for the remainder of this research study. This decision was reached partly because of the significant radiation dose delivered from labeled WBC and safety issues related to preparing these labeled cells. Final diagnosis was based on microbiological examinations of the surgical specimens in 125 prostheses and joint aspirations combined with the clinical follow-up of 6 months or more in 86 prostheses. The sensitivity, specificity, positive predictive value, and negative predictive value of FDG PET in hip prostheses were 81.8%, 93.1%, 79.4%, and 94.0%, respectively, and in knee prostheses were 94.7%, 88.2%, 69.2%, and 98.4%, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of WBC/BM imaging in hip prostheses were 38.5%, 95.7%, 71.4%, and 84.6%, respectively, and in knee prostheses were 33.3%, 88.5%, 25.0%, and 92.0%, respectively. In those cases that underwent both FDG PET and WBC/BM imaging, there was a trend (P = 0.0625) toward a higher sensitivity for FDG PET in hip prostheses, whereas other comparisons did not show any significant differences between the 2 imaging modalities.Based on this study, the diagnostic performance of FDG PET scan in detecting infection in painful hip and knee prostheses is optimal for routine clinical application. Considering the complexity and costs of WBC/BM imaging and related safety issues associated with this preparation, FDG PET seems to be an appropriate alternative for assessing these patients.

The purpose of this study was to evaluate the outcome of femoral component revisions using a long tapered HA coated femoral revision stem. Between 2001 and 2008, 55 femoral component revisions were performed using this stem. Forty-one patients were available for follow up evaluation at average of 59 months. The clinical results were evaluated using the HHS and serial radiographs were evaluated for loosening. The mean HHS was 71 (range 22–100). Three hips required revision of KAR stem (1 aseptic loosening, 1 infection, 1 limb length discrepancy). Only one prosthesis demonstrated radiographic evidence of subsidence. Our study suggests that long tapered HA coated revision femoral components can provide stable fixation and in-growth in cases where there is good proximal femoral bone stock and favorable canal geometry.

Between 2000 and 2004, 89 hybrid alumina-on-alumina hip replacements were performed by a single surgeon. There were 46 men and 43 women with an average age of 51 years. All patients were followed up for a minimum of 10 years. Prior to surgery, the mean Harris hip score (HHS) was 44 points (35–55). Following surgery, the HHS improved to an average of 94 points (87–100). There was no significant decline in pain and function even into the second decade following hip replacement. At final follow-up, the average UCLA activity score was 7.3 (range: 3–10). No osteolysis was observed at a mean radiographic follow-up of 123 months. One patient (2 hips) required revision surgery for bilateral femoral component loosening at 11.2 years and 11.9 years, respectively. There were no cases of ceramic fractures or squeaking in this series. Survivorship at 13.5 years with implant revision for any reason as the end point was 96.2%. Consequently, hybrid alumina-on-alumina total hip arthroplasty in this series provided reliable and durable and functioned well into the second decade with low wear rates and high survivorship.

Ceramic components׳ clinical fractures in total hip arthroplasty (THA) are a rare but, nonetheless, serious complication. As a result of continued improvements in ceramic material quality, manufacturing methods, and implant design made over the last 30 years, the incidence of such failures has been drastically reduced. In this report, the frequency of these ceramic components׳ clinical failures in THA will be examined. In addition, some information regarding the contribution that can be made by the surgeon to enhance the reliability of ceramic components will also be presented. In order to get a broad view, the largest supplier of these components, CeramTec Medical Products (Plochingen, Germany), was contacted, and they agreed to share their most recent data. In the year 2000, the largest supplier of alumina–ceramic bearings for orthopedic applications (CeramTec GmbH, Plochingen, Germany) began a rigorous program of collecting clinical fracture data for all of its ceramic components. The clinical fracture data for the period of January 2000–June 2013 are reported here, with a review of the material properties, historical component fracture trends, and relative risk of fracture associated with alumina THA bearings. The data reported is divided into two separate groups. The first one is the incidence of clinical fracture of the Biolox ® forte material. This is their original material developed in the 1970s and is still available today and optimized over the years. The overall clinical fracture rate of these alumina components was 0.021%, or 21 in 100,000, during the January 2000–June 2013 time period. The second group is composed of components manufactured from their Alumina Matrix Composite, Biolox ® delta . The overall clinical fracture rate for these components is 0.0001% or 1 in 100,000. Almost 80% of these alumina bearing failures occurred within 36 months following surgery. Using the latest material and increasing femoral head diameter were associated with a substantially reduced risk of fracture. Alumina bearings used in modern THA implants are safe and reliable, with a very low risk of failure. Improvements in the materials, developments in the manufacturing, the introduction of the Alumina Matrix Composite, and the trend to utilize larger-diameter ball heads are likely to continue to reduce the concerns that have been in the mind of surgeons using ceramics in THA.

Saline-coupled bipolar sealing has shown mixed results in primary arthroplasty. However, this technology has not been studied in infected revision total hip arthroplasty (THA), where morbidity is higher and conventional methods of blood management, such as cell salvage, often cannot be used. This case-matched study of 76 consecutive revision THA for infection included an experimental bipolar sealing group and a control group of conventional electrocautery. Groups were matched for gender, body mass index, American Society of Anesthesiologists classification, and surgery type. Total blood loss, intraoperative blood loss, and perioperative hemoglobin drop were significantly less in the experimental group. In addition, operative time was significantly shorter in the experimental group, which translated into gross savings approximately equal to the cost of the device. The decreases in total blood loss and perioperative hemoglobin decline, along with financial savings, may support the use of bipolar sealing in infected revision THA.

Revision total knee arthroplasty can be complicated by severe patellar bone loss, precluding the use of standard cemented patellar components. This study evaluated the midterm outcomes of porous tantalum (PT) patellar components. Twenty-three PT components were used in 6 men and 17 women (average age, 62 years). All patellae had less than 10-mm residual thickness. The PT shell was secured to host bone, and a 3-peg polyethylene component was cemented onto the shell. In 2 patients, the PT component was sutured directly to extensor mechanism. Average follow-up was 7.7 years (range, 5-10 years). At follow-up, the Knee Society scores for pain and function averaged 82.7 and 33.3, respectively, whereas the mean Oxford knee score was 32.6. Four patients underwent revision surgery. Survivorship was 19 (83%) of 23 patients. Porous tantalum patellar components can provide fixation where severe bone loss precludes the use of traditional implants. Failures were associated with avascular residual bone and fixation of components to the extensor mechanism.

t L i Sir John Charnley, in the early 1960s, began the orthopedic revolution of joint replacement surgery with his lowriction arthroplasty.1 Years earlier, he had been unsuccessful with a similar design, but with an inferior material, Teflon. Although the use of medical-grade polyethylene seemed to provide good midterm results, there were a number of individuals who had some doubt about the durability of this metalon-plastic combination developed by Charnley. McKee was concerned with polyethylene and developed a metal–metal hip replacement in the mid 1960s. Other substitute materials for the polyethylene were sought, and in 1970, the Parisian, Boutin, performed the first ceramic–ceramic total hip replacement.2 The feeling then was the same as the one today; alumina is an excellent bearing material because of its hardness and scratch resistance. This first ceramic hip was performed cementless on the acetabular side, whereas the ceramic ball was cemented to the femoral stem. Although the tribological properties of alumina ceramics for joint replacement were appreciated as early as 1970, there were other practical issues. The material was quite brittle, and fractures could occur, and they did, but infrequently, as the cementing of the ceramic ball to the trunnion of the stem was an adequate way to prevent high levels of stress caused by an imprecise fit of the components. However, the lack of fixation on the acetabular side often led to loosening and pain, although rarely was there significant bone loss due to the lack of inflammatory particles. This early loosening of the socket was addressed in 2 ways: the French camp decided to cement the alumina socket, whereas Mittlemeier, from Germany, created a new system that now used a threaded ceramic cup that was “screwed” into the acetabulum.3 This new system also used a ress-fit femoral component and more precise manufacturng of the ceramic ball and the metal trunnion of the femoral omponent. This manufacturing improvement led to the limination of cement as a fixation material required for the ating of the ball to the stem. Although both camps enjoyed

As we enter the 4th decade of use, ceramic-on-ceramic total hip arthroplasty remains a viable bearing surface for young and active patients requiring hip replacement. Improvements in manufacturing and component design have continually improved reliability and safety of these implants. Furthermore, the latest iteration of ceramics, which allows for larger head diameters and more head and liner combinations, has further leveled the playing field when it comes to hard-on-hard bearing surfaces. Finally, with recent reports of early failures and unexplained idiosyncratic reactions in patients with metal-on-metal arthroplasty, we suggest that surgeons faced with young and active patients should consider ceramics, with its excellent wear characteristics and biocompatibility, as the only safe hard-on-hard bearing surface suitable for implantation.

A significant increase in younger patients undergoing total knee arthroplasty raises the theoretical concern for revision secondary to micromotion and fixation failure with cemented components. We prospectively studied 100 consecutive tantalum monoblock uncemented tibial components and 312 concurrent cemented controls. Patients younger than 55 years with adequate bone stock were enrolled. This cementless patient group was younger and had higher preoperative functional status. Prostheses were posterior-substituting uncemented femoral and tibial components with a cemented patellar button. Knee Society pain and function scores and radiographs were obtained, and a cost analysis was performed. Knee Society scores were excellent and equivalent beyond 6 months. There was no significant difference in perioperative blood loss, complication rates, or cost. There was a significant decrease in operative time in the uncemented group. Radiographs revealed no failures of ingrowth at last follow-up. There were 3 uncemented group failures, but none were due to failure of fixation. The use of a porous tantalum tibia at minimum 5 years has yielded promising clinical and radiographic results in a younger patient population.

Recent technologic advances in total hip arthroplasty (THA) have focused on improving the longevity and wear characteristics of bearing surfaces that can withstand the high demands of younger and more active patients. Recent reports of early failures of metal-on-metal THA have introduced doubts to its ability to be a viable long-term hard-on-hard bearing surface for hip arthroplasty. Like metal-on-metal, ceramic-on-ceramic (COC) bearing surfaces have excellent in vitro wear characteristics, but there is little information about their long-term track record in vivo, particularly in those patients who are younger and more active. The purpose of this study is to evaluate the long-term outcomes of COC THA in active patients younger than 50 years of age. We retrospectively reviewed 82 consecutive THAs in 64 patients performed by a single surgeon from 1997 to 2000. There were 42 men and 22 women with an average age of 38.6 years. Of the 82 THAs, 39 were performed for avascular necrosis of the hip, 30 for osteoarthritis, 8 for developmental dysplasia, and 5 for inflammatory or posttraumatic arthritis. Clinical outcomes were evaluated using the Harris hip score, and serial radiographs were evaluated for signs of component loosening. The mean follow-up period was 10.1 (range, 10.0-12.3) years. One patient died, and another was lost to follow-up. The mean Harris hip score was 89.8. There were no implants with subsidence or circumferential radiolucent lines. Two patients required revision surgery of their THA for a ceramic liner fracture. One patient complained of squeaking that required revision. There were no cases of revision for ceramic head fracture, instability, or aseptic loosening. At a minimum 10-year follow-up, the survivorship of the COC THA was 96.3%. Modern COC THA in active patients younger than 50 years of age is durable at a minimum 10-year follow-up; however, patients should be advised of the small chance of squeaking and ceramic fracture.

†Background: Aseptic loosening of cemented hip prostheses is recognized as a long-term problem, and especially in males and younger patients. Much energy has been focused on developing new prostheses that are designed for cementless fixation. We evaluated the performance of and periprosthetic bone response to a tapered, titanium, hydroxyapatite (HA)-coated femoral hip prosthesis at a minimum of 7 years of follow-up after treatment with primary total hip arthroplasty. Methods: Seventy-eight patients and 86 hips were included in the study. There were 35 men and 43 women; the mean age at the time of the operation was 59 years (range, 41 to 81 years). We used a tapered, titanium (Ti6Al4V), HA-coated femoral implant. We evaluated the patients at a minimum of 7 years of follow-up after treatment with primary total hip arthroplasty. Clinical evaluation was performed using the scoring system and the hip scores were assigned according to the level of pain, the functional status and the range of motion. The patients who refused to return, but who did forward X-rays for review after being contacted were questioned by phone about the functional status of their hip. Radiographic follow-up was performed at six weeks, at three, six and twelve months and yearly thereafter. All the available radiographs were collected and assessed for implant stability, subsidence, osseointegration, osteolysis, stress shielding and evidence of periprosthetic lucency. Results: Eighty-six hips (78 patients) were available for review at follow-up of greater than 7 years. In 11 of the 86 cases, acetabular failure required revision of the acetabular component, but the femoral stem survived and it was available for long-term evaluation. The radiographs were obtained at 7-year follow-up for another 20 hips, but the patients would not come in for the 7-year clinical evaluation. Therefore, a phone interview was conducted to assess any change in the functional status at a minimum of 7 years. Conclusions: The mechanical fixation of a tapered, titanium, HA-coated femoral implant was excellent in this study. This femoral design provided reliable osseointegration that was durable at a mean of 7 years follow-up.

A poll was initially attempted to elucidate what type of skin incision would be preferred by the patients. The retrospective analysis of index cases was preformed to reveal the gains and losses of small incision transgluteal THA. We performed a poll on the preferred type of skin incision to the patients, their families and the medical personnel in orthopedic department in a face-to-face manner. According to the result of the poll, we changed approaches from a standard transgluteal to a small incision transgluteal approach. Each 20 consecutive index patients that underwent standard or small-incision transgluteal THA were followed and compared for more than 2 years. The small incision THA group showed more rapid mobilization, shorter hospital stay, and better early satisfaction. However, no clinical benefits of small incision were observed after 6-weeks postoperatively. There were significant variations in implant alignments. More early major complications such as dislocation, intraoperative femoral fracture or leg length inequalities occurred in the small incision group. The use of a small incision in THA resulted in subtle and temporary gains, at the cost of several major early complications. Now we perform THA with definitely smaller incision than before but we do believe that performing a stable and well-aligned THA is far more important than the length or amount of surgical dissection.

The most commonly used bearing couple in prosthetic hip or knee joint replacements consists of a cobalt–chrome (CoCr) metal alloy articulating against ultrahigh-molecular-weight polyethylene. Ceramics have been used as an alternative to metal-on-polyethylene in joint replacement surgery of arthritic hips and knees since the 1970s. In prosthetic hip and knee bearings, ceramic surfaces offer a major benefit of drastically reduced wear rates and excellent long-term biocompatibility, which can increase the longevity of prosthetic hip and knee joints. This benefit is important clinically because hip and knee replacement has become a very common surgical procedure, particularly in the United States, and because these procedures are being increasingly performed in younger patients who place greater demands on the prosthetic bearings. However, ceramics are brittle and the risk of catastrophic bearing failure in vivo, while rare, is a major concern. Improvements in material quality, manufacturing methods, and implant design have resulted in a drastic reduction of the incidence of such failures, so that modern ceramic bearings are safe and reliable if used with components of proven design and durability. Future material improvements are actively being investigated to reduce the risk of ceramic-bearing failures even further. The purpose of this article is to review the structure, properties, applications, and limitations of the ceramics that have been used in orthopedic bearings, and to describe the new ceramic composite materials and surface treatments that will be available for joint replacement surgery in the near future.

The performance of, and periprosthetic bone response to, a tapered, titanium (Ti6Al4V), hydroxyapatite-coated femoral hip prosthesis was evaluated at minimum of 10 years of follow-up. Data were prospectively collected on 147 consecutive primary hip arthroplasties performed in 133 patients by a single surgeon during a 2-year interval. Clinical and radiographic analyses of 96 hips in 86 patients were independently performed by 2 surgeons who were not involved in the care of these patients. There were no cases of aseptic loosening of the femoral component. Subsidence and stress shielding occurred in 5% and 2% of cases, respectively, and was not clinically significant. In all 15 hips that required revision of the acetabular component, the femoral component was found to be well fixed, without any occurrence of distal osteolysis. This femoral design provided reliable osseointegration that was durable at a mean of 11.5 years of follow-up.

Bearings made of ceramics have ultra-low wear properties that make them suitable for total hip arthroplasty (THA) and total knee arthroplasty (TKA). When compared to cobalt chrome (CoCr)-on-polyethylene (PE) articulations, ceramics offer drastic reductions in bearing wear rates. Lower wear rates result in fewer wear particles produced by the articulating surfaces. In theory, this should reduce the risk of periprosthetic osteolysis and premature implant loosening, thereby contributing to the longevity of total joints. In addition to ceramics, other alternative bearing couples, such as highly cross-linked PE (XLPE) and metal-on-metal also offer less wear than CoCr-on-PE articulations in total joint arthroplasty.Alumina and zirconia ceramics are familiar to orthopaedic surgeons since both materials have been used in total joints for several decades. While not new in Europe, alumina-on-alumina ceramic total hips have only recently become available for widespread use in the United States from various orthopaedic implant manufacturers. As the search for the ideal total joint bearing material continues, composite materials of existing ceramics, metal-on-ceramic articulations, and new ceramic technologies will offer more choices to the arthroplasty surgeon. The objective of this paper is to present an overview of material properties, clinical applications, evolution, and limitations of ceramic materials that are of interest to the arthroplasty surgeon.

Risk of infection is considerable in open fractures, especially when fracture fixation devices are used to stabilize the fractured bones. Overall deep infection rates of 16.2% have been reported. The infection rate is even greater, up to 32.2%, with external fixation of femoral fractures. The use of percutaneous implants for certain clinical applications, such as percutaneous implants for external fracture fixation, still represents a challenge today. Currently, bone infections are very difficult to treat. Very potent antibiotics are needed, which creates the risk of irreversible damage to other organs, when the antibiotics are administered systemically. As such, controlled, local release is being pursued, but no such treatments are in clinical use. Herein, the use of bactericidal micron-thin sol-gel films on metallic fracture fixation pins is reported. The data demonstrates that triclosan (2,4,4'-trichloro-2'-hydroxydiphenylether), an antimicrobial agent, can be successfully incorporated into micron-thin sol-gel films deposited on percutaneous pins. The sol-gel films continuously release triclosan in vitro for durations exceeding 8 weeks (longest measured time point). The bactericidal effect of the micron-thin sol-gel films follows from both in vitro and in vivo studies. Inserting percutaneous pins in distal rabbit tibiae, there were no signs of infection around implants coated with a micron-thin sol-gel/triclosan film. Healing had progressed normally, bone tissue growth was normal and there was no epithelial downgrowth. This result was in contrast with the results in rabbits that received control, uncoated percutaneous pins, in which abundant signs of infection and epithelial downgrowth were observed. Thus, well-adherent, micron-thin sol-gel films laden with a bactericidal molecule successfully prevented pin tract infection.

Purpose.To review the outcomes of 65 patients younger than 55 years who underwent uncemented total hip arthroplasty (THA) using third-generation ceramic-on-ceramic prostheses.Methods.Medical records of 30 men and 35 women (80 hips) aged 18 to 55 (mean, 39) years who underwent uncemented THA using third-generation ceramic-on-ceramic prostheses by a single surgeon were reviewed. 61 THAs used the Reflection cup with the Synergy stem (n=49), Spectron stem (n=7), or Anthology stem (n=5), and 19 THAs used the Trident cup with the Secur-Fit stem. Outcomes were assessed based on the UCLA Activity Score and Harris Hip Score, as well as radiolucency around the implants, malposition, and subsidence on radiographs. Patients were asked about their satisfaction with current activity level (yes/no), activity limitation (no limitation, musculoskeletal limitation, psychological impediments and lack of motivation, and pain or disability of the operative hip), and change in occupational activity level (same or similar, more active, and less active or disability).Results.The mean follow-up period was 54 (range, 24–110) months. Six patients were excluded from the analysis owing to prosthetic failure secondary to ceramic liner fracture after falling (n=2), acetabular component loosening (n=1), intolerable squeak (n=1), periprosthetic fracture (n=1), and instability (n=1). The mean UCLA Activity Score improved from 4.0 (range, 1–10) to 7.7 (range, 2–10) [pConclusion.Ceramic-on-ceramic THA achieved acceptable clinical and radiographic outcomes.

Background: Several studies have documented that the size of the osteonecrotic lesion in the femoral head is an essential parameter in determining prognosis and treatment. There are several methods currently available to measure lesion size, but no general agreement as to which is most useful. In the present study, three different radiographic methods for determining lesion size were evaluated and compared. Methods: Anteroposterior and lateral radiographs of forty-two hips with osteonecrosis were examined. The extent of osteonecrotic involvement of the femoral head was determined through the use of three different methods: the volume of necrosis by quantitative digital image analysis, and the angular measurements described by Kerboul et al. and Koo and Kim. Graphs were constructed to demonstrate these relationships. Results: Volumetric measurement appeared to be the most reliable. There was only a rough correlation with angular measurements. Several sources of error were noted when simple angular measurements of irregular, three-dimensional lesions were used. The Kerboul method routinely overestimated lesion size and designated 81% of the lesions as “large.” The modified Koo and Kim method provided a more even distribution of lesion size and correlated with volumetric measurements in 74% of hips (thirty-one of forty-two hips). Conclusions: Quantitative volumetric measurements appear to be the most reliable method to measure the true size of a three-dimensional osteonecrotic lesion of the femoral head. Volumetric measurement is more accurate than angular measurement and can be performed easily with modern technology. Angular measurements, although somewhat simpler to use than volumetric measurements, may provide only a rough estimate of lesion size, partly due to the considerable differences in outline or location of the necrotic segments. Nevertheless, determination of lesion size must be part of a comprehensive system of staging of this disease, which includes the evaluation of other parameters, such as the extent and degree of articular surface involvement and the status of the hip joint and the acetabulum. Level of Evidence: Diagnostic Level III. See Instructions to Authors on [jbjs.org][1] for a complete description of levels of evidence. [1]: http://jbjs.org

Ceramic bearing failure in total hip arthroplasty (THA) is a rare but serious complication. The incidence of such failures has declined steadily because of improvements in ceramic material quality, manufacturing methods, and implant design. The incidence of failures of the Biolox (CeramTec AG, Plochingen, Germany) forte brand of alumina components produced by CeramTec was 0.02%, or 2 in 10,000 from January 2000 to May 2006. The current estimation of the risk of an alumina THA bearing failure is 2 in 10,000 cases; most of these failures involve alumina femoral heads. Alumina bearings used in modern THA implants are safe and reliable, with a very low risk of failure.

We aimed to compare the accuracy of fluorodeoxyglucose positron emission tomography (FDG-PET) with technetium-99m sulfur colloid 111indium-labeled white blood cell scintigraphy (TcSC-Ind BM/WBC) in diagnosis of periprosthetic infection. Eighty-nine patients with 92 painful hip prostheses were recruited prospectively and given the option of undergoing either combined FDG-PET and TcSC-Ind BM/WBC or FDG-PET only. FDG-PET correctly diagnosed 20 of the 21 infected cases (sensitivity, 95.2%) and ruled out infection in 66 of the 71 aseptic hips (specificity, 93%) corresponding to a positive predictive value of 80% (20/25) and a negative predictive value of 98.5% (66/67). TcSC-Ind BM/WBC correctly identified 5 of the 10 infected cases (sensitivity, 50%) and 39 of 41 aseptic cases (specificity, 95.1%) corresponding to a positive and negative predictive values of 41.7% (5/12 cases) and 88.6% (39/44 cases), respectively. Based on these preliminary results, FDG-PET appears to be a promising diagnostic tool for distinguishing septic from aseptic painful hip prostheses.

Bearing surfaces made of ceramic materials are an alternative to metal-on-polyethylene (PE) articulations in total hip arthroplasty and total knee arthroplasty. The advantage of ceramic surfaces in total joints is the reduction in wear rates compared with metal-on-PE. Lower wear rates result in a decreased volume of wear particles produced by the articulating surfaces. In theory, this should reduce the risk of periprosthetic osteolysis and premature implant loosening, thereby contributing to the longevity of prosthetic joints. In addition to ceramics, other alternative bearings, such as highly cross-linked PE and metal-on-metal, also offer decreased wear rates when compared with metal-on-PE articulations in total joint arthroplasty. Alumina and zirconia ceramics are familiar to orthopedic surgeons because both materials have a long history of use in total joint bearings. Alumina-on-alumina ceramic total hip articulations are now available in the United States from several implant manufacturers. Composite materials made by combining alumina and zirconia, metal-on-ceramic articulations, and new ceramic materials will offer even more choices as the search for the ideal bearing combination in total joint arthroplasty continues. The purpose of this article is to review the material properties, clinical applications, evolution, and limitations of the ceramic materials used in total joint bearings.

Bearing wear and associated osteolysis are the most common problems affecting the long-term results of total hip arthroplasty. Alumina ceramic–ceramic bearings have been introduced as one method of addressing these problems. The current study reviews the clinical outcome of the use of alumina ceramic–ceramic bearings in the United States and specifically reports on the 2- to 8-year results of a prospective FDA–ID. Results demonstrate that the alumina ceramic–ceramic bearings are reliable and show very few early problems. Ceramic fractures do occur rarely and may be similar in incidence to reports of fractures or disassociations of polyethylene components. The incidence of instability is extremely low despite the absence of lipped liners and fewer head-length options.

Osteonecrosis of the hip is the final common pathway for a group of disorders that results in ischemia of the femoral head. Etiologies include disruption of vessels, external vascular occlusion, embolization, thrombosis, cytotoxicity, and idiopathic causes. As a result of the ischemia cell death occurs and the bone is weakened leading to collapse and eventual degenerative changes to the hip. Early diagnosis is crucial for the successful treatment of osteonecrosis. Unfortunately, most patients' conditions result in total hip arthroplasty. Here we review the etiology, diagnosis and current treatment options.

Bioactive glass granules were implanted in the paraspinal muscle of rabbits to determine the pathway of the silicon released from bioactive glass in vivo. We traced and quantified the silicon released by obtaining 24-h urine and blood samples for up to 6 months after implantation. Furthermore, local muscle tissue as well as the following organs were resected for chemical and histopathological analyses: brain, heart, kidney, liver, lung, lymph nodes, spleen, and thymus. The urinary silicon of the group with implanted granules was significantly higher than in the sham-operated, control group. The average excretion rate was 2.4 mg/day, and as such, 100% of the implanted silicon was excreted in 19 weeks. No elevated concentrations of silicon were found at the implant sites or in the other organs at sacrifice, that is, 24 weeks. The histological appearance of all organs was normal throughout. The concentrations of silicon measured in the urine were well below saturation and because no significant increase in silicon was found in any organ, including kidney, the increased silicon excretion rate was within the physiological capacity of rabbits. Therefore, it can be concluded that the resorbed silica gel is harmlessly excreted in soluble form through the urine.

Hip arthroplasty is a common surgical procedure, but the diagnosis of infection associated with hip arthroplasty remains challenging. Fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) has been shown to be a promising imaging modality in settings where infection is suspected. However, inflammatory reaction to surgery can result in increased FDG uptake at various anatomic locations, which may erroneously be interpreted as sites of infection. The purpose of this study was to assess the patterns and time course of FDG accumulation following total hip replacement over an extended period of time. Firstly, in a prospective study nine patients with total hip replacement were investigated to determine the patterns of FDG uptake over time. Three FDG-PET scans were performed in each patient at about 3, 6 and 12 months post arthroplasty. Secondly, in a retrospective analysis, the medical and surgical history and FDG-PET imaging results of 710 patients who had undergone whole-body scans for the evaluation of possible malignant disorders were reviewed. The history of arthroplasty and FDG-PET findings in the hip region were reviewed for this study. Patients with symptomatic arthroplasties or related complaints during FDG-PET scanning were excluded from the analysis. During the entire study period, all nine patients enrolled in the prospective study were demonstrated to have increased FDG uptake around the femoral head or neck portion of the prosthesis that extended to the soft tissues surrounding the femur. Among the patients reviewed in the retrospective study, 18 patients with a history of 21 hip arthroplasties who were asymptomatic at the time of FDG-PET scan met the criteria for inclusion. The time interval between the hip arthroplasty and the FDG-PET study ranged from 3 months to 288 months (mean+/-SD: 80.4+/-86.2 months). In 81% (17 of 21) of these prostheses, increased FDG uptake could be noted around the femoral head or neck portion of the prosthesis. The average time interval between arthroplasty and FDG-PET scan in these patients was 71.3 months. In only four prostheses (19%, 4 of 21) was no abnormally increased FDG uptake seen around the prostheses or adjacent sites. The average time interval in these patients was 114.8 months. It is concluded that following hip arthroplasty, non-specifically increased FDG uptake around the head or neck of the prosthesis persists for many years, even in patients without any complications. Therefore, to minimize the number of false-positive results for infection with PET studies obtained to evaluate a painful hip prosthesis, caution should be exercised when interpreting FDG uptake around the head or neck portion of the prosthesis.

Impaction grafting has been used successfully in revision total knee arthroplasty. Histology and preliminary clinical results show that this technique may be useful in situations in which bone loss is extensive. In contrast to bulk allografts, morcellized graft remodels and incorporates with the host. The preliminary results and technique are reviewed briefly.

Background: In an effort to decrease the rate of aseptic loosening, certain cemented femoral components were designed to have a roughened or textured surface with a methylmethacrylate precoating. Reports differ as to whether this step has increased or decreased the rate of failure. This study was designed to evaluate this issue. Methods: Five hundred and fourteen hips treated with a cemented Harris Precoat stem (Zimmer, Warsaw, Indiana) were evaluated clinically and radiographically and compared with 254 hips treated with an uncoated Harris Design-2 stem (Howmedica, East Rutherford, New Jersey). Prostheses that had been removed at revision were examined. The cementing and surgical techniques were identical and the population demographics were similar for these two groups. Results: The mean durations of follow-up were 8.4 and 13.5 years for the Precoat and uncoated Design-2 stems, respectively. At those times, at least forty-nine (9.5%) of the 514 Precoat components and at least ten (3.9%) of the 254 uncoated Design-2 stems had failed (p = 0.006). Five Precoat stems fractured, and no uncoated Design-2 stems fractured. Component failure was associated with use in young, active, heavy men with a diagnosis of avascular necrosis and generally with the use of smaller components. The cementing technique was satisfactory in the majority of the patients, and there were no qualitative differences in cementing technique between the hips that failed and those that did not. The mechanisms of failure of the Precoat prostheses included bone-cement loosening, focal osteolysis, stem fracture, and prosthesis-cement debonding. Fractures of smaller components occurred as a result of fatigue failure and were associated with good distal fixation but proximal stem loosening. Conclusions: The rate of failure of roughened, precoated, cemented femoral components was considerably higher and occurred earlier than that of femoral components that were neither textured nor precoated with methylmethacrylate. Younger patients with avascular necrosis had a higher risk of failure; however, this factor alone did not completely explain the differences in outcome between these two components. The causes of aseptic loosening are multifactorial and may be related to component design and size as well as to precoating and surface finish.

The use of an elevated-rim acetabular liner in total hip arthroplasty is widely accepted. We sought to determine quantitatively the amount of additional stability provided by the elevated-rim liner compared with the standard nonelevated liner. The stability of the hip with a 32-mm femoral head was compared with the standard 28-mm head. Our results show that a 15 degrees elevated-rim acetabular liner placed in the posterior quadrant increased hip stability by an additional 8.9 degrees of internal rotation. Similarly the 32-mm head provided 8.1 degrees of additional internal rotation. The increases were statistically significant (P

Bioactive glass granules were implanted in the tibiae of rabbits in order to determine the pathway of the silicon released from bioactive glass in vivo. We traced and quantified the silicon released by obtaining 24-h urine samples and blood samples for up to 7 months after implantation. Bone tissue as well as the following organs were resected for chemical and histopathological analyses: kidney, liver, lung, lymph nodes, and spleen. The urinary silicon of the implanted group was significantly higher than in the control group. From the data, the calculated average excretion rate was approximately 1.8 mg/day, and as such, the amount of implanted silicon was excreted within statistical bounds in 24 weeks. At this point, only elevated concentrations of silicon were found at the implant site and not in the other organs. The concentrations of silicon measured in the urine were well below saturation. Since no significant increase in silicon was found in any of the organs including the kidney, the increased silicon excretion rate was within the physiological capacity of rabbits. Therefore, it can be concluded that the resorbed silica gel is harmlessly excreted in soluble form through the urine.

The development of periprosthetic fractures around loose femoral components can be a devastating event for patients who have undergone total hip arthroplasty (THA). As indications for THA expand in an aging population and to use in younger patients, these fractures are increasing in incidence. This review covers the epidemiology, risk factors, prevention, and clinical management of periprosthetic femoral fractures. Treatment principles and reconstructive options are discussed, along with outcomes and complications. Femoral revision with a long-stem prosthesis or a modular tapered stem is the mainstay of treatment and has demonstrated good outcomes in the literature. Other reconstruction options are available, depending on bone quality. Surgeons must have a sound understanding of the diagnosis and treatment of periprosthetic femoral fractures.

This article discusses current bearing-surface alternatives for long-term total hip articulations involving metal-polyethylene, ceramic-polyethylene, metal-metal, and ceramic-ceramic couples. The enduring success of the low-friction arthroplasty advanced by Sir John Charnley as a solution for painful hip problems can be appreciated by the fact that, in 1999, more than 270,000 hip arthroplasties were performed in the United States. Over the last three decades, patient profiles have changed substantially, resulting in demands for a greater service life of ultra-high molecular weight polyethylene hip components. Material failure, often leading to an osteolytic response, is increasingly associated with younger, more active patients. In this context, the low-friction solution has become a problem, limiting in vivo system longevity (Figs. 1 and 2). Fig. 1: A marked osteolytic response in a fifty-year-old patient. Fig. 2: Corresponding intracellular polyethylene debris viewed under polarized light. Previous attempts to improve the performance of ultra-high molecular weight polyethylene have included carbon-fiber reinforcement (Poly-2) and, more recently, polymer reprocessing to enhance mechanical properties (Hylamer). The former was withdrawn from the market because of excessive inflammatory response, whereas the latter has been linked to debris-induced osteolytic responses in early reports. Laboratory simulation has demonstrated that the resistance of ultra-high molecular weight polyethylene to wear is improved with increased cross-linking of the carbon-hydrogen polymer chains. A number of thermal and chemical processing solutions have been described. One such approach involves component storage at elevated temperatures in an oxygen-depleted environment. This is done following irradiation and encourages kinetic recombination of the carbon-hydrogen free radicals created by the radiation process. Other techniques deliver increased radiation doses to the component material followed by remelting to quench free radicals. While this results in dramatic wear reduction in laboratory simulations (Fig. 3), it also changes the amorphous and crystalline regions of the polymer, affecting mechanical properties and potentially reducing fatigue strength. …

In 1997, two manufacturers began Food and Drug Administration approved investigations of a ceramic-on-ceramic (alumina) articulation total hip replacement in the United States. Osteonics (Allendale, NJ) and Wright Medical Technology (Arlington, TN) enrolled more than 500 and 300 patients, respectively, when their studies ended in the middle part of 1998. The author presents detailed early results of the series by Wright Medical Technology. Three hundred thirty-three patients were enrolled in 11 centers around the country in a prospective series. All patients received the Transcend ceramic-on-ceramic articulation and have a minimum of 18 months followup with a range of 18 to 36 months. Harris hip scores increased on average from 44 to 97 points. Four patients underwent revision surgery; one for deep infection, one for early migration of the cup, one for dislocation, and one for liner malplacement. Overall, there were 42 complications. Seven were systemic and 35 were related to the total hip replacement. Four of the 35 complications were ceramic related and included three chipped liners and one eccentric seating of the cup liner. To date, no patient underwent revision surgery for aseptic loosening. Seven technical guidelines are suggested to enhance the quality of the intraoperative and postoperative results: a conservative femoral neck cut; horizontal cup placement (45 degrees); increased anteverted cup placement (20 degrees); use of trial liners; impaction of ceramic pieces; hand placement of the liner; and removal of osteophytes and/or part of the anterior wall of the acetabulum to avoid impingement. Alternate bearing articulations, particularly ceramics, have important technical aspects to be considered at the time of implantation to minimize intraoperative and postoperative complications. To date, there have been no postoperative fractures of the ceramic pieces in any of the completed or ongoing ceramic-on-ceramic investigations by all involved manufacturers. These preliminary results are satisfactory at this time. One can look to the future with cautious optimism.

Efforts to avoid complications associated with transfusion of allogeneic blood have increased the use of preoperatively donated autologous blood (PAB). A major controversy has arisen: Should the same criteria be used for transfusion of autologous as allogeneic red cells? This study prospectively and randomly compared giving PAB immediately after total knee arthroplasty (TKA), beginning in the recovery room or delaying a transfusion until the patient's hemoglobin had fallen to less than a 9.0 g/dL transfusion trigger point. The results show that patients who received immediate transfusion had fewer nonsurgical complications (P < .002). Because TKAs are associated with an average blood loss of 1,400 mL, we recommend that PAB be used in the immediate postoperative period, especially in the elderly, in whom the risk for cardiac or nonsurgical complications is inherently increased.

Bioactive glass fibers were investigated for use as a fixation vehicle between a low modulus, polymeric composite and bone tissue. In an initial pilot study, bioactive glass fiber/polysulfone composites and all-polysulfone control rods were implanted into the rabbit tibia; the study was subsequently expanded with implantation into the rabbit femur. Bone tissue exhibited direct contact with the glass fibers and adjacent polymer matrix and displayed a mechanical bond between the composite and bone tissue after six weeks implantation. Interfacial bond strengths after six weeks implantation averaged 12.4 MPa, significantly higher than those of the all-polymer controls. Failure sites for the composite at six weeks generally occurred in the bone tissue or composite, whereas the failure site for the polymer implants occurred exclusively at the implant/tissue interface. The bioactive glass fiber/polysulfone composite achieved fixation to bone tissue through a triple mechanism: a bond to the bioactive glass fiber, mechanical interlocking between the tissue and glass fibers, and close apposition and possible chemical bond between the portions of the polymer and bone tissue. This last mechanism resulted from an overspill of bioactivity reactions from the fibers onto the surface of the surrounding polymer which we call the “halo” effect. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 161–170, 1998.

Periprosthetic infection is an increasingly prevalent and challenging problem in joint reconstruction. We present a technical report of a custom spacer for management of an infected total knee arthroplasty (TKA) and concomitant severe bone loss. The spacer was designed to provide sufficient leg length, soft tissue tension, and limb stability in preparation for ultimate limb reconstruction. This technique and custom spacer serve as an alternative for managing significant bone loss in infected knee arthroplasty.

We report six cases where significant postoperative pain persisted in individuals following arthroscopic surgery augmented with the use of lasers. Subsequent magnetic resonance images showed lesions with signal changes compatible with the diagnosis of osteonecrosis in areas directly addressed with laser energy.