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4. Preoperative CA 19-9 Predicts Disease Progression in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: An Analysis from the US HIPEC Collaborative

Author

Fackche, Nadege T., Schmocker, Ryan K., Nudotor, Richard, Kubi, Boateng, Cloyd, Jordan M., Grotz, Travis E., Fournier, Keith F., Dineen, Sean P., Veerapong, Jula, Baumgartner, Joel M., Clarke, Callisia N., Patel, Sameer H., Wilson, Gregory C., Lambert, Laura A., Pokrzywa, Courtney, Abbott, Daniel E., Lee, Byrne, Staley, Charles A., Zaidi, Mohammad Y., Johnston, Fabian M., and Greer, Jonathan B.

Published
2024
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12. Neighborhood-Level Socioeconomic Disadvantage Predicts Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy

Author

Winicki, Nolan M., Radomski, Shannon N., Florissi, Isabella S., Cloyd, Jordan M., Gutta, Goutam, Grotz, Travis E., Scally, Christopher P., Fournier, Keith F., Dineen, Sean P., Powers, Benjamin D., Veerapong, Jula, Baumgartner, Joel M., Clarke, Callisia N., Kothari, Anai N., Maduekwe, Ugwuji N., Patel, Sameer H., Wilson, Gregory C., Schwartz, Patrick, Varley, Patrick R., Raoof, Mustafa, Lee, Byrne, Malik, Ibrahim, Johnston, Fabian M., and Greer, Jonathan B.

Published
2023
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18. Validation of the AJCC 8th Edition Staging System for Disseminated Appendiceal Cancer Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Multi-institutional Analysis

Author

SenthilKumar, Gopika, Kothari, Anai N., Maduekwe, Ugwuji N., Fournier, Keith, Abbott, Daniel E., Wilson, Gregory C., Patel, Sameer H., Greer, Jonathan, Johnston, Fabian, Dineen, Sean P., Powers, Benjamin D., Baumgartner, Joel, Veerapong, Jula, Leiting, Jennifer, Grotz, Travis E., Maithel, Shishir K., Staley, Charles, Raoof, Mustafa, Lambert, Laura, Lee, Andrew, Kim, Alex, Cloyd, Jordan M., and Mogal, Harveshp

Published
2023
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21. Weekend Discharge Is Not Associated With Increased Readmission After Hyperthermic Intraperitoneal Chemotherapy

Author

Florissi, Isabella, Radomski, Shannon N., Shou, Benjamin, Cloyd, Jordan M., Kim, Alex, Grotz, Travis, Fournier, Keith, Baumgartner, Joel M., Lambert, Laura, Abbott, Daniel E., Schwartz, Patrick, Staley, Charles A., Clarke, Callisia, Dineen, Sean, Patel, Sameer H., Wilson, Gregory C., Raoof, Mustafa, Johnston, Fabian M., and Greer, Jonathan B.

Published
2024
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23. ASO Visual Abstract: Neighborhood Level Socioeconomic Disadvantage Predicts Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy

Author

Winicki, Nolan M., Radomski, Shannon N., Florissi, Isabella S., Cloyd, Jordan M., Gutta, Goutam, Grotz, Travis E., Scally, Christopher P., Fournier, Keith F., Dineen, Sean P., Powers, Benjamin D., Veerapong, Jula, Baumgartner, Joel M., Clarke, Callisia N., Kothari, Anai N., Maduekwe, Ugwuji N., Patel, Sameer H., Wilson, Gregory C., Schwartz, Patrick, Varley, Patrick R., Raoof, Mustafa, Lee, Byrne, Malik, Ibrahim, Johnston, Fabian M., and Greer, Jonathan B.

Published
2023
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25. Conditional Survival Following Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies: An Analysis from the US HIPEC Collaborative

Author

Beal, Eliza W., Srinivas, Shruthi, Shen, Chengli, Kim, Alex, Johnston, Fabian M., Greer, Jonathan, Abbott, Daniel E., Pokrzywa, Courtney, Raoof, Mustafa, Grotz, Travis E., Leiting, Jennifer L., Fournier, Keith, Dineen, Sean, Powers, Benjamin, Veerapong, Jula, Kothari, Anai, Maduekew, Ugwuji, Maithel, Shishir, Wilson, Gregory C., Patel, Sameer H., Lambert, Laura, Abdel-Misih, Sherif, and Cloyd, Jordan M.

Published
2023
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29. A novel preoperative risk score to optimize patient selection for performing concomitant liver resection with cytoreductive surgery/HIPEC

Author

Lee, Rachel M, Gamboa, Adriana C, Turgeon, Michael K, Zaidi, Mohammad Y, Kimbrough, Charles, Leiting, Jennifer, Grotz, Travis, Lee, Andrew J, Fournier, Keith, Powers, Benjamin, Dineen, Sean, Baumgartner, Joel M, Veerapong, Jula, Mogal, Harveshp, Clarke, Callisia, Wilson, Gregory, Patel, Sameer, Hendrix, Ryan, Lambert, Laura, Pokrzywa, Courtney, Abbott, Daniel E, LaRocca, Christopher J, Raoof, Mustafa, Greer, Jonathan, Johnston, Fabian M, Staley, Charles A, Cloyd, Jordan M, Maithel, Shishir K, and Russell, Maria C

Subjects
Clinical Research, Digestive Diseases, Liver Disease, Patient Safety, Colo-Rectal Cancer, Cancer, Evaluation of treatments and therapeutic interventions, 6.4 Surgery, Appendiceal Neoplasms, Chemotherapy, Cancer, Regional Perfusion, Colorectal Neoplasms, Combined Modality Therapy, Cytoreduction Surgical Procedures, Female, Follow-Up Studies, Hepatectomy, Humans, Hyperthermia, Induced, Male, Middle Aged, Patient Selection, Peritoneal Neoplasms, Preoperative Care, Prognosis, Risk Factors, Survival Rate, appendiceal adenocarcinoma, colorectal cancer, HIPEC, liver resection, risk score, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundWhile parenchymal hepatic metastases were previously considered a contraindication to cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC), liver resection (LR) is increasingly performed with CRS/HIPEC.MethodsPatients from the US HIPEC Collaborative (2000-2017) with invasive appendiceal or colorectal adenocarcinoma undergoing primary, curative intent CRS/HIPEC with CC0-1 resection were included. LR was defined as a formal parenchymal resection. Primary endpoints were postoperative complications and overall survival (OS).ResultsA total of 658 patients were included. About 83 (15%) underwent LR of colorectal (58%) or invasive appendiceal (42%) metastases. LR patients had more complications (81% vs. 60%; p = .001), greater number of complications (2.3 vs. 1.5; p

Published
2021

30. Implications of Postoperative Complications for Survival After Cytoreductive Surgery and HIPEC: A Multi-Institutional Analysis of the US HIPEC Collaborative

Author

Gamboa, Adriana C, Lee, Rachel M, Turgeon, Michael K, Zaidi, Mohammad Y, Kimbrough, Charles W, Grotz, Travis E, Leiting, Jennifer, Fournier, Keith, Lee, Andrew J, Dineen, Sean P, Powers, Benjamin D, Veerapong, Jula, Baumgartner, Joel M, Clarke, Callisia N, Mogal, Harveshp, Patel, Sameer H, Lee, Tiffany C, Lambert, Laura A, Hendrix, Ryan J, Abbott, Daniel E, Pokrzywa, Courtney, Raoof, Mustafa, Eng, Oliver S, Johnston, Fabian M, Greer, Jonathan, Cloyd, Jordan M, Maithel, Shishir K, and Staley, Charles A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Digestive Diseases, Colo-Rectal Cancer, Clinical Research, Cancer, Good Health and Well Being, Aged, Antineoplastic Combined Chemotherapy Protocols, Appendiceal Neoplasms, Cytoreduction Surgical Procedures, Female, Humans, Hyperthermic Intraperitoneal Chemotherapy, Male, Middle Aged, Peritoneal Neoplasms, Postoperative Complications, Retrospective Studies, Survival Rate, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundPostoperative complications (POCs) are associated with worse oncologic outcomes in various cancer histologies. The impact of POCs on the survival of patients with appendiceal or colorectal cancer after cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is unknown.MethodsThe US HIPEC Collaborative (2000-2017) was reviewed for patients who underwent CCR0/1 CRS/HIPEC for appendiceal/colorectal cancer. The analysis was stratified by noninvasive appendiceal neoplasm versus invasive appendiceal/colorectal adenocarcinoma. The POCs were grouped into infectious, cardiopulmonary, thromboembolic, and intestinal dysmotility. The primary outcomes were overall survival (OS) and recurrence-free survival (RFS).ResultsOf the 1304 patients, 33% had noninvasive appendiceal neoplasm (n = 426), and 67% had invasive appendiceal/colorectal adenocarcinoma (n = 878). In the noninvasive appendiceal cohort, POCs were identified in 55% of the patients (n = 233). The 3-year OS and RFS did not differ between the patients who experienced a complication and those who did not (OS, 94% vs 94%, p = 0.26; RFS, 68% vs 60%, p = 0.15). In the invasive appendiceal/colorectal adenocarcinoma cohort, however, POCs (63%; n = 555) were associated with decreased 3-year OS (59% vs 74%; p

Published
2020

31. Do Lymph Node Metastases Matter in Appendiceal Cancer with Peritoneal Carcinomatosis? A US HIPEC Collaborative Study

Author

Turner, Kevin M., Morris, Mackenzie C., Delman, Aaron M., Hanseman, Dennis, Johnston, Fabian M., Greer, Jonathan, Walle, Kara Vande, Abbott, Daniel E., Raoof, Mustafa, Grotz, Travis E., Fournier, Keith, Dineen, Sean, Veerapong, Jula, Maduekwe, Ugwuji, Kothari, Anai, Staley, Charles A., Maithel, Shishir K., Lambert, Laura A., Kim, Alex C., Cloyd, Jordan M., Wilson, Gregory C., Sussman, Jeffrey J., Ahmad, Syed A., and Patel, Sameer H.

Published
2022
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33. ASO Visual Abstract: Validation of the AJCC 8th Edition Staging System for Disseminated Appendiceal Cancer Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy—A Multi-institutional Analysis

Author

SenthilKumar, Gopika, Kothari, Anai N., Maduekwe, Ugwuji N., Fournier, Keith, Abbott, Daniel E., Wilson, Gregory C., Patel, Sameer H., Greer, Jonathan, Johnston, Fabian, Dineen, Sean P., Powers, Benjamin D., Baumgartner, Joel, Veerapong, Jula, Leiting, Jennifer, Grotz, Travis E., Maithel, Shishir K., Staley, Charles, Raoof, Mustafa, Lambert, Laura, Lee, Andrew, Kim, Alex, Cloyd, Jordan M., and Mogal, Harveshp

Published
2023
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34. Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative

Author

Leiting, Jennifer L, Cloyd, Jordan M, Ahmed, Ahmed, Fournier, Keith, Lee, Andrew J, Dessureault, Sophie, Felder, Seth, Veerapong, Jula, Baumgartner, Joel M, Clarke, Callisia, Mogal, Harveshp, Staley, Charles A, Zaidi, Mohammad Y, Patel, Sameer H, Ahmad, Syed A, Hendrix, Ryan J, Lambert, Laura, Abbott, Daniel E, Pokrzywa, Courtney, Raoof, Mustafa, LaRocca, Christopher J, Johnston, Fabian M, Greer, Jonathan, and Grotz, Travis E

Subjects
Clinical Research, Cancer, Digestive Diseases, Evaluation of treatments and therapeutic interventions, 6.4 Surgery, Mucinous appendiceal carcinoma, Cytoreductive surgery, Multi-institutional
Abstract

BackgroundCytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis can be performed in two ways: Open or closed abdominal technique.AimTo evaluate the impact of HIPEC method on post-operative and long-term survival outcomes.MethodsPatients undergoing CRS with HIPEC from 2000-2017 were identified in the United States HIPEC collaborative database. Post-operative, recurrence, and overall survival outcomes were compared between those who received open vs closed HIPEC.ResultsOf the 1812 patients undergoing curative-intent CRS and HIPEC, 372 (21%) patients underwent open HIPEC and 1440 (79%) underwent closed HIPEC. There was no difference in re-operation or severe complications between the two groups. Closed HIPEC had higher rates of 90-d readmission while open HIPEC had a higher rate of 90-d mortalities. On multi-variable analysis, closed HIPEC technique was not a significant predictor for overall survival (hazards ratio: 0.75, 95% confidence interval: 0.51-1.10, P = 0.14) or recurrence-free survival (hazards ratio: 1.39, 95% confidence interval: 1.00-1.93, P = 0.05) in the entire cohort. These findings remained consistent in the appendiceal and the colorectal subgroups.ConclusionIn this multi-institutional analysis, the HIPEC method was not independently associated with relevant post-operative or long-term outcomes. HIPEC technique may be left to the discretion of the operating surgeon.

Published
2020

35. Impact of Neoadjuvant Chemotherapy on the Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases: A Multi-Institutional Retrospective Review.

Author

Beal, Eliza W, Suarez-Kelly, Lorena P, Kimbrough, Charles W, Johnston, Fabian M, Greer, Jonathan, Abbott, Daniel E, Pokrzywa, Courtney, Raoof, Mustafa, Lee, Byrne, Grotz, Travis E, Leiting, Jennifer L, Fournier, Keith, Lee, Andrew J, Dineen, Sean P, Powers, Benjamin, Veerapong, Jula, Baumgartner, Joel M, Clarke, Callisia, Mogal, Harveshp, Russell, Marti C, Zaidi, Mohammed Y, Patel, Sameer H, Dhar, Vikrom, Lambert, Laura, Hendrix, Ryan J, Hays, John, Abdel-Misih, Sherif, and Cloyd, Jordan M

Subjects
colorectal peritoneal metastases, cytoreductive surgery, hyperthermic intraperitoneal chemotherapy, Clinical Sciences
Abstract

Cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with improved survival for patients with colorectal peritoneal metastases (CR-PM). However, the role of neoadjuvant chemotherapy (NAC) prior to CRS-HIPEC is poorly understood. A retrospective review of adult patients with CR-PM who underwent CRS+/-HIPEC from 2000-2017 was performed. Among 298 patients who underwent CRS+/-HIPEC, 196 (65.8%) received NAC while 102 (34.2%) underwent surgery first (SF). Patients who received NAC had lower peritoneal cancer index score (12.1 + 7.9 vs. 14.3 + 8.5, p = 0.034). There was no significant difference in grade III/IV complications (22.4% vs. 16.7%, p = 0.650), readmission (32.3% vs. 23.5%, p = 0.114), or 30-day mortality (1.5% vs. 2.9%, p = 0.411) between groups. NAC patients experienced longer overall survival (OS) (median 32.7 vs. 22.0 months, p = 0.044) but similar recurrence-free survival (RFS) (median 13.8 vs. 13.0 months, p = 0.456). After controlling for confounding factors, NAC was not independently associated with improved OS (OR 0.80) or RFS (OR 1.04). Among patients who underwent CRS+/-HIPEC for CR-PM, the use of NAC was associated with improved OS that did not persist on multivariable analysis. However, NAC prior to CRS+/-HIPEC was a safe and feasible strategy for CR-PM, which may aid in the appropriate selection of patients for aggressive cytoreductive surgery.

Published
2020

38. Implementation Barriers and Recommendations for a Multisite Community Health Worker Intervention in Palliative Care for African American Oncology Patients: A Qualitative Study

Author

Woods, Alison P., primary, Monton, Olivia, additional, Fuller, Shannon M., additional, Siddiqi, Amn, additional, Errichetti, Cheryl Lyn, additional, Masroor, Taleaa, additional, Joyner, Robert L., additional, Elk, Ronit, additional, Owczarzak, Jill, additional, and Johnston, Fabian M., additional

Published
2024
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43. Prognostic Significance of Preoperative Tumor Markers in Pseudomyxoma Peritonei from Low-Grade Appendiceal Mucinous Neoplasm: a Study from the US HIPEC Collaborative

Author

Nizam, Wasay, Fackche, Nadege, Pessoa, Bernardo, Kubi, Boateng, Cloyd, Jordan M., Grotz, Travis, Fournier, Keith, Dineen, Sean, Veerapong, Jula, Baumgartner, Joel M., Clarke, Callisia, Patel, Sameer H., Wilson, Gregory C., Lambert, Laura, Abbott, Daniel E., Vande Walle, Kara A., Lee, Byrne, Raoof, Mustafa, Maithel, Shishir K., Russell, Maria C., Zaidi, Mohammad Y., Johnston, Fabian M., and Greer, Jonathan B.

Published
2022
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45. ASO Visual Abstract: Conditional Survival After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies: An Analysis from the US HIPEC Collaborative

Author

Beal, Eliza W., Srinivas, Shruthi, Shen, Chengli, Kim, Alex, Johnston, Fabian M., Greer, Jonathan, Abbott, Daniel E., Pokrzywa, Courtney, Raoof, Mustafa, Grotz, Travis E., Leiting, Jennifer L., Fournier, Keith, Dineen, Sean, Powers, Benjamin, Veerapong, Jula, Kothari, Anai, Maduekew, Ugwuji, Maithel, Shishir, Wilson, Gregory C., Patel, Sameer H., Lambert, Laura, Abdel-Misih, Sherif, and Cloyd, Jordan M.

Published
2023
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49. The Utility of Preoperative Tumor Markers in Peritoneal Carcinomatosis from Primary Appendiceal Adenocarcinoma: an Analysis from the US HIPEC Collaborative

Author

Fackche, Nadege, Schmocker, Ryan K., Kubi, Boateng, Cloyd, Jordan M., Ahmed, Ahmed, Grotz, Travis, Leiting, Jennifer, Fournier, Keith, Lee, Andrew J., Powers, Benjamin, Dineen, Sean, Veerapong, Jula, Baumgartner, Joel M., Clarke, Callisia, Gamblin, T. Clark, Patel, Sameer H., Dhar, Vikrom, Hendrix, Ryan J., Lambert, Laura, Abbott, Daniel E., Pokrzywa, Courtney, Lafaro, Kelly, Lee, Byrne, Zaidi, Mohammad Y., Maithel, Shishir K., Johnston, Fabian M., and Greer, Jonathan B.

Published
2021
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50. Contributors

Author

Ardiles, Victoria, primary, Baghdadi, Azarakhsh, additional, Bertens, Kimberly, additional, Blair, Alex B., additional, Bonner, Sidra, additional, Brauer, David G., additional, Brodt, Pnina, additional, Clarke, Callisia N, additional, Clary, Bryan, additional, Court, Colin M., additional, D'Angelica, Michael I, additional, De Santibañes, Eduardo, additional, De Santibañes, Martin, additional, Dua, Monica M., additional, Ejaz, Aslam, additional, Fonseca, Gilton Marques, additional, Geller, David A., additional, Guest, Rachel V, additional, Hamad, Ahmad, additional, Herman, Joseph M., additional, Herman, Paulo, additional, Hill, Colin S., additional, Johnston, Fabian, additional, Kamel, Ihab R., additional, Koay, Eugene J., additional, Kopecky, Kimberly, additional, Kruger, Jaime Arthur Pirolla, additional, Lidsky, Michael E, additional, Liu, Elizabeth Y., additional, Manne, Ashish, additional, Martel, Guillaume, additional, Narayan, Raja R., additional, Nathan, Hari, additional, Noonan, Anne, additional, Nyström, Hanna, additional, Parks, Rowan, additional, Pawlik, Timothy M., additional, Radomski, Shannon, additional, Reames, Bradley N., additional, Rocha, Flavio, additional, Sharib, Jeremy, additional, Siegel, Peter M., additional, Tenner, Laura L., additional, Ward, Erin P, additional, Washington, Kimberly, additional, Wei, Alice C., additional, and Zheng, Jian, additional

Published
2022
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