36 results on '"Johnson-Sabine E"'
Search Results
2. Motivation to change in recent onset and long-standing bulimia nervosa: Are there differences?
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Perkins, S., Schmidt, U., Eisler, I., Treasure, J., Berelowitz, M., Dodge, E., Frost, S., Jenkins, M., Johnson-Sabine, E., Keville, S., Murphy, R., Robinson, P., Winn, S., and Yi, I.
- Published
- 2007
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3. New variant Creutzfeldt-Jakob disease: psychiatric features
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Zeidler, M, Johnstone, E C, Bamber, R W K, Dickens, C M, Fisher, C J, Francis, A F, Goldbeck, R, Higgo, R, Johnson-Sabine, E C, Lodge, G J, McGarry, P, Mitchell, S, Tarlo, L, Turner, M, Ryley, P, and Will, R G
- Published
- 1997
4. Bulimia outcome
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Reiss, D and Johnson-Sabine, E
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- 2016
5. A randomized controlled trial of family therapy and cognitive-behavioral guided self-care for adolescents with bulimia nervosa or related disorders
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Schmidt, U, Lee, S, Beecham, Jennifer, Perkins, S, Treasure, J, Yi, I, Winn, S, Robinson, Peter, Murphy, R, Keville, S, Johnson-Sabine, E, Jenkins, M, Frost, S, Dodge, L, Berelowitz, M, and Eisler, I
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HN Social history and conditions. Social problems. Social reform - Abstract
Objective: To date no trial has focused on the treatment of adolescents with bulimia nervosa. The aim of this study was to compare the efficacy and cost-effectiveness of family therapy and cognitive behavior therapy (CBT) guided self-care in adolescents with bulimia nervosa or eating disorder not otherwise specified. Method: Eighty-five adolescents with bulimia nervosa or eating disorder not otherwise specified were recruited from eating disorder services in the United Kingdom. Participants were randomly assigned to family therapy for bulimia nervosa or individual CBT guided self-care supported by a health professional. The primary outcome measures were abstinence from binge-eating and vomiting, as assessed by interview at end of treatment (6 months) and again at 12 months. Secondary outcome measures included other bulimic symptoms and cost of care. Results: Of the 85 study participants, 41 were assigned to family therapy and 44 to CBT guided self-care. At 6 months, bingeing had undergone a significantly greater reduction in the guided self-care group than in the family therapy group; however, this difference disappeared at 12 months. There were no other differences between groups in behavioral or attitudinal eating disorder symptoms. The direct cost of treatment was lower for guided self-care than for family therapy. The two treatments did not differ in other cost categories. Conclusions: Compared with family therapy, CBT guided self-care has the slight advantage of offering a more rapid reduction of bingeing, lower cost, and greater acceptability for adolescents with bulimia or eating disorder not otherwise specified.
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- 2007
6. Incidence of psychotic illness in London: comparison of ethnic groups
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King, M, primary, Coker, E, additional, Leavey, G, additional, Hoare, A, additional, and Johnson-Sabine, E, additional
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- 1994
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7. Bulimia nervosa: a 5-year follow-up study
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Johnson-Sabine, E., primary, Reiss, D., additional, and Dayson, D., additional
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- 1992
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8. A randomized controlled trial of family therapy and cognitive behavior therapy guided self-care for adolescents with bulimia nervosa and related disorders.
- Author
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Schmidt U, Lee S, Beecham J, Perkins S, Treasure J, Yi I, Winn S, Robinson P, Murphy R, Keville S, Johnson-Sabine E, Jenkins M, Frost S, Dodge L, Berelowitz M, Eisler I, Schmidt, Ulrike, Lee, Sally, Beecham, Jennifer, and Perkins, Sarah
- Abstract
Objective: To date no trial has focused on the treatment of adolescents with bulimia nervosa. The aim of this study was to compare the efficacy and cost-effectiveness of family therapy and cognitive behavior therapy (CBT) guided self-care in adolescents with bulimia nervosa or eating disorder not otherwise specified.Method: Eighty-five adolescents with bulimia nervosa or eating disorder not otherwise specified were recruited from eating disorder services in the United Kingdom. Participants were randomly assigned to family therapy for bulimia nervosa or individual CBT guided self-care supported by a health professional. The primary outcome measures were abstinence from binge-eating and vomiting, as assessed by interview at end of treatment (6 months) and again at 12 months. Secondary outcome measures included other bulimic symptoms and cost of care.Results: Of the 85 study participants, 41 were assigned to family therapy and 44 to CBT guided self-care. At 6 months, bingeing had undergone a significantly greater reduction in the guided self-care group than in the family therapy group; however, this difference disappeared at 12 months. There were no other differences between groups in behavioral or attitudinal eating disorder symptoms. The direct cost of treatment was lower for guided self-care than for family therapy. The two treatments did not differ in other cost categories.Conclusions: Compared with family therapy, CBT guided self-care has the slight advantage of offering a more rapid reduction of bingeing, lower cost, and greater acceptability for adolescents with bulimia or eating disorder not otherwise specified. [ABSTRACT FROM AUTHOR]- Published
- 2007
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9. Abnormal eating attitudes in London schoolgirls — a prospective epidemiological study: outcome at twelve month follow-up
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Patton, G. C., primary, Johnson-Sabine, E., additional, Wood, K., additional, Mann, A. H., additional, and Wakeling, A., additional
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- 1990
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10. A randomized controlled trial of a brief intervention for families of patients with a first episode of psychosis.
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Leavey G, Gulamhussein S, Papadopoulos C, Johnson-Sabine E, Blizard B, and King M
- Abstract
BACKGROUND: Carers' satisfaction with psychiatric services related to information and advice is generally poor. This may be particularly true for services trying to meet the needs of ethnically diverse communities. It is important that services attempt to ameliorate carers' concerns as early as possible. The authors aimed to assess the impact of a brief educational and advice support service on carers of patients with a first episode of psychotic illness. METHOD: Carers of all patients identified with a first episode of psychosis in a defined psychiatric catchment area of North London were invited to participate. Following consent from patients and relatives, relatives were randomly allocated to receive (in addition to usual services) a brief intervention comprising education and advice about the disorder from a support team or to usual care from community psychiatric services. RESULTS: One hundred and six carers were recruited to the study. Take-up of the intervention was less than expected and the intervention had little impact. The authors found no differences over time between the randomized arms for relatives' satisfaction (F = 23, p = 0 .4, df = 1) or number of days spent by patients in hospital over nine months from entry to the trial (F= 1.7, p= 0.18, df = 1). CONCLUSIONS: It was found that the support and advice intervention for families had little impact on their satisfaction or on patients' outcomes. However, failure to take up the intervention threatens the conclusions as the power to show an effect was reduced. Although family interventions, in general, are considered an important adjunct to the treatment of patients with chronic psychosis, there may be difficulties in providing an educational and support intervention shortly after first onset. How and when psychiatric services provide information and advice to carers of people newly diagnosed with a psychosis requires further study. [ABSTRACT FROM AUTHOR]
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- 2004
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11. Ethnicity and outcome of psychosis.
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Goater, Nicky, King, Michael, Cole, Eleanor, Leavey, Gerard, Johnson-Sabine, Eric, Blizard, Robert, Hoar, Amanda, Goater, N, King, M, Cole, E, Leavey, G, Johnson-Sabine, E, Blizard, R, and Hoar, A
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MENTAL illness ,PEOPLE with mental illness ,MENTAL health ,PSYCHOLOGY of Black people ,ETHNOPSYCHOLOGY - Abstract
Background: An excess of psychotic illness in Black people has been found in cross-sectional studies. Little is known about the outcome of psychosis in different ethnic groups in the UK.Aims: To compare the incidence, nature and long-term outcome of psychosis in different ethnic groups.Method: A five-year, prospective study of an epidemiological cohort of people with a first contact for psychosis.Results: Age-standardised incidence rates for schizophrenia and non-affective psychosis were higher for Black and Asian people than Whites. Stability of diagnosis and course of illness were similar in all ethnic groups. During the fifth year, Black people were more likely than others to be detained, brought to hospital by the police and given emergency injections.Conclusions: The nature and outcome of psychotic illness is similar in all ethnic groups but Black people experience more adverse contacts with services later in the course of illness. [ABSTRACT FROM AUTHOR]- Published
- 1999
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12. First-onset psychotic illness: patients' and relatives' satisfaction with services.
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Leavey, Gerard, King, Michael, Cole, Eleanor, Hoar, Amanda, Johnson-Sabine, Eric, Leavey, G, King, M, Cole, E, Hoar, A, and Johnson-Sabine, E
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PEOPLE with mental illness ,PATIENT satisfaction ,MENTAL health services ,HOSPITAL care ,MENTAL health laws ,HEALTH behavior - Abstract
Background: Despite the growth in patient satisfaction studies, scant attention has been paid to the satisfaction of patients with a first episode of psychotic illness soon after presentation to services. We were particularly interested in any ethnic differences in satisfaction at this seminal stage in patient care.Method: Using multi-item questionnaire, face-to-face interviews were conducted with patients and relatives 12 months after first contact with psychiatric services. Relatives were also questioned on support and advice issues related to after-care.Results: Most patients and relatives were generally satisfied with the treatment, and with the 'humane' qualities of psychiatric staff, but were less satisfied with the 'hotel' aspects of hospital care. Patients, and particularly relatives, were most concerned about levels of information and advice received. Relatives were dissatisfied with after-care. There were no significant differences between Black and other patients, but some differences between their relatives. Patients born abroad were significantly more satisfied than those born in Britain, irrespective of ethnicity. Compulsory detention under the Mental Health Act was also significant in determining low satisfaction for patients and especially for their relatives.Conclusions: For improved care in the community patients and their relatives need to be seen as partners in care rather than as passive recipients. The issue of information-giving by psychiatric services demands serious attention. Black patients and their relatives were not especially likely to be dissatisfied. [ABSTRACT FROM AUTHOR]- Published
- 1997
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13. Pathways to care for patients with a first episode of psychosis. A comparison of ethnic groups.
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Cole, Eleanor, Leavey, Gerard, King, Michael, Johnson-Sabine, Eric, Hoar, Amanda, Cole, E, Leavey, G, King, M, Johnson-Sabine, E, and Hoar, A
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PSYCHOSES ,PATHOLOGICAL psychology ,MENTAL health services ,ETHNIC groups ,EPIDEMIOLOGY ,INVOLUNTARY treatment - Abstract
Background: It is reported that patients from ethnic minority groups, in particular Afro-Caribbeans, are more likely to enter less desirable pathways to psychiatric care. We aimed to determine whether ethnicity significantly affected time to presentation, type of first contact, rates of compulsory admission and police and primary care involvement, in patients with their first episode of psychosis.Method: As part of a prospective epidemiological study, patients and their carers were interviewed using a semi-structured questionnaire to trace the various persons and agencies seen en route to their first contact with psychiatric services.Results: While compulsory admission was more likely for Black patients, the excess was less striking than in previous studies. Black patients were no more likely than other patients to have police involvement. The most important factors in avoiding an adverse pathway were having a supportive family member or friend and the presence of a general practitioner to assist in gaining access to psychiatric services.Conclusions: The routes to psychiatric services for first onset patients are different to those for chronic patients. Variables associated with social support were more important than ethnicity in determining pathways to care. Police involvement and compulsory admissions were strongly associated with the absence of GP involvement and the absence of help-seeking by a friend or relative. It may be that ethnicity becomes an important variable after the patient has come into contact with psychiatric services. [ABSTRACT FROM AUTHOR]- Published
- 1995
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14. Physical illness. A risk factor in anorexia nervosa.
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Patton, G. C., Wood, K., and Johnson-Sabine, E.
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ANOREXIA nervosa ,EATING disorders ,BODY image ,DISEASE risk factors ,DIAGNOSIS ,EPIDEMIOLOGY ,DISEASE complications ,AGE distribution ,COMPARATIVE studies ,DIGESTIVE system diseases ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,RELATIVE medical risk ,RETROSPECTIVE studies ,ACUTE diseases - Abstract
Reports have appeared in the literature suggesting an association between physical illness and the later development of anorexia nervosa. The histories of 326 patients with anorexia nervosa were examined for physical illness. A higher rate of severe physical illness was found in this group when compared with controls suggesting that it should be regarded as a risk factor for anorexia nervosa. No statistically significant differences were found when illness was examined by time in relation to onset of anorexia, system involved, or when subjects were stratified by age. Possible explanations for the observed association are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 1986
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15. Mood changes in bulimia nervosa.
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Johnson-Sabine, E. C., Wood, K. H., and Wakeling, A.
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MOOD (Psychology) ,BULIMIA ,FOOD habits ,EATING disorders ,COMPULSIVE eating ,VOMITING ,ANOREXIA nervosa ,HYPERPHAGIA ,ANXIETY ,MENTAL depression ,EMOTIONS ,PSYCHOLOGICAL tests ,PSYCHOLOGY - Abstract
Daily measurement of mood, and the occurrence of specific eating behaviours, were assessed concurrently over an eight-week period in a sample of 50 patients meeting diagnostic criteria for bulimia nervosa. Results of observer-rated scales of mood showed a significant reduction of scores, whereas self-assessment of mood showed no change over the study period. Negative mood states, although not severe, were more marked when the specific behavioural symptoms of binge-eating, vomiting, or purging occurred, and they increased as abnormal eating behaviours accumulated. It is suggested that the accompanying dysphoric mood states of bulimia nervosa are likely to be a secondary manifestation related to the presence of abnormal eating symptoms, and that they do no constitute a primary depressive illness. [ABSTRACT FROM AUTHOR]
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- 1984
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16. Bouffée délirante: an examination of its current status.
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Johnson-Sabine, E. C., Mann, A. H., Jacoby, R. J., Wood, K. H., Peron-Magnan, P., Olié, J. P., and Deniker, P.
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- 1983
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17. Physical Illness
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Patton, G. C., primary, Wood, K., additional, and Johnson-Sabine, E., additional
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- 1986
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18. Therapist written goodbye letters: evidence for therapeutic benefits in the treatment of anorexia nervosa.
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Simmonds J, Allen KL, O'Hara CB, Bartholdy S, Renwick B, Keyes A, Lose A, Kenyon M, DeJong H, Broadbent H, Loomes R, McClelland J, Serpell L, Richards L, Johnson-Sabine E, Boughton N, Whitehead L, Treasure J, Wade T, and Schmidt U
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- Adult, Ambulatory Care, Humans, Outpatients, Psychotherapy, Anorexia Nervosa therapy, Feeding and Eating Disorders
- Abstract
Background: Despite their use in clinical practice, there is little evidence to support the use of therapist written goodbye letters as therapeutic tools. However, preliminary evidence suggests that goodbye letters may have benefits in the treatment of anorexia nervosa (AN)., Aims: This study aimed to examine whether therapist written goodbye letters were associated with improvements in body mass index (BMI) and eating disorder symptomology in patients with AN after treatment., Method: Participants were adults with AN (n = 41) who received The Maudsley Model of Anorexia Treatment for Adults (MANTRA) in a clinical trial evaluating two AN out-patient treatments. As part of MANTRA, therapists wrote goodbye letters to patients. A rating scheme was developed to rate letters for structure and quality. Linear regression analyses were used to examine associations between goodbye letter scores and outcomes after treatment., Results: Higher quality letters and letters that adopted a more affirming stance were associated with greater improvements in BMI at 12 months. Neither the overall quality nor the style of goodbye letters were associated with improvements in BMI at 24 months or reductions in eating disorder symptomology at either 12 or 24 months., Conclusions: The results highlight the potential importance of paying attention to the overall quality of therapist written goodbye letters in the treatment of AN, and adopting an affirming stance.
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- 2020
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19. Written case formulations in the treatment of anorexia nervosa: Evidence for therapeutic benefits.
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Allen KL, O'Hara CB, Bartholdy S, Renwick B, Keyes A, Lose A, Kenyon M, DeJong H, Broadbent H, Loomes R, McClelland J, Serpell L, Richards L, Johnson-Sabine E, Boughton N, Whitehead L, Treasure J, Wade T, and Schmidt U
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- Adolescent, Adult, Ambulatory Care methods, Anorexia Nervosa psychology, Body Mass Index, Communication, Female, Humans, Male, Medical Writing, Middle Aged, Motivation, Outpatients, Patient Satisfaction, Surveys and Questionnaires, Treatment Outcome, Young Adult, Anorexia Nervosa therapy, Psychotherapy methods
- Abstract
Objective: Case formulation is a core component of many psychotherapies and formulation letters may provide an opportunity to enhance the therapeutic alliance and improve treatment outcomes. This study aimed to determine if formulation letters predict treatment satisfaction, session attendance, and symptom reductions in anorexia nervosa (AN). It was hypothesized that higher quality formulation letters would predict greater treatment satisfaction, a greater number of attended sessions, and greater improvement in eating disorder symptoms., Method: Patients were adult outpatients with AN (n = 46) who received Maudsley Anorexia Nervosa Treatment for Adults (MANTRA) in the context of a clinical trial. A Case Formulation Rating Scheme was used to rate letters for adherence to the MANTRA model and use of a collaborative, reflective, affirming stance. Analyses included linear regression and mixed models., Results: Formulation letters that paid attention to the development of the AN predicted greater treatment acceptability ratings (p = 0.002). More reflective and respectful letters predicted greater reductions in Eating Disorder Examination scores (p = 0.003)., Discussion: Results highlight the potential significance of a particular style of written formulation as part of treatment for AN. Future research should examine applicability to other psychiatric disorders. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2016; 49:874-882)., (© 2016 Wiley Periodicals, Inc.)
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- 2016
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20. Two-year follow-up of the MOSAIC trial: A multicenter randomized controlled trial comparing two psychological treatments in adult outpatients with broadly defined anorexia nervosa.
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Schmidt U, Ryan EG, Bartholdy S, Renwick B, Keyes A, O'Hara C, McClelland J, Lose A, Kenyon M, Dejong H, Broadbent H, Loomes R, Serpell L, Richards L, Johnson-Sabine E, Boughton N, Whitehead L, Bonin E, Beecham J, Landau S, and Treasure J
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- Adult, Ambulatory Care methods, Anorexia Nervosa psychology, Day Care, Medical statistics & numerical data, Female, Follow-Up Studies, Hospitalization, Humans, Male, Outpatients, Treatment Outcome, Anorexia Nervosa therapy, Psychotherapy methods
- Abstract
Objective: This study reports follow-up data from a multicenter randomized controlled trial (n = 142) comparing the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with broadly defined anorexia nervosa (AN). At 12 months postrandomization, all patients had statistically significant improvements in body mass index (BMI), eating disorder (ED) symptomatology and other outcomes with no differences between groups. MANTRA was more acceptable to patients. The present study assessed whether gains were maintained at 24 months postrandomization., Methods: Follow-up data at 24 months were obtained from 73.2% of participants. Outcome measures included BMI, ED symptomatology, distress, impairment, and additional service utilization during the study period. Outcomes were analyzed using linear mixed models., Results: There were few differences between groups. In both treatment groups, improvements in BMI, ED symptomatology, distress levels, and clinical impairment were maintained or increased further. Estimated mean BMI change from baseline to 24 months was 2.16 kg/m(2) for SSCM and 2.25 kg/m(2) for MANTRA (effect sizes of 1.75 and 1.83, respectively). Most participants (83%) did not require any additional intensive treatments (e.g., hospitalization). Two SSCM patients became overweight through binge-eating., Discussion: Both treatments have value as outpatient interventions for patients with AN. © 2016 Crown copyright. International Journal of Eating Disorders. (Int J Eat Disord 2016; 49:793-800)., (© 2016 Crown copyright. International Journal of Eating Disorders.)
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- 2016
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21. Process evaluation of the MOSAIC trial: treatment experience of two psychological therapies for out-patient treatment of Anorexia Nervosa.
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Zainal KA, Renwick B, Keyes A, Lose A, Kenyon M, DeJong H, Broadbent H, Serpell L, Richards L, Johnson-Sabine E, Boughton N, Whitehead L, Treasure J, and Schmidt U
- Abstract
Background: This study is part of a series of process evaluations within the MOSAIC Trial (Maudsley Outpatient Study of Treatments for Anorexia Nervosa and Related Conditions). This randomised controlled trial (RCT) compared two psychological treatments, the Maudsley Model for Treatment of Adults with Anorexia Nervosa (MANTRA) and Specialist Supportive Clinical Management (SSCM) for adult outpatients with Anorexia Nervosa. The present process study integrates quantitative (treatment acceptability and credibility) and qualitative (written) feedback to evaluate patients' treatment experiences., Method: All 142 MOSAIC participants were asked to (a) rate treatment acceptability and credibility on visual analogue scales (VAS) at six and 12 months post-randomisation, and (b) provide written feedback regarding their views on their treatment at 12 months. Transcripts were first analysed thematically and then rated according to the global valence of feedback (positive, mixed/negative)., Results: 114/142 (80.3 %) MOSAIC participants provided VAS data and 82 (57.7 %) provided written feedback. At 12 months, MANTRA patients gave significantly higher acceptability and credibility ratings compared to SSCM patients. A significantly higher proportion of MANTRA patients provided written feedback. MANTRA patients also tended to write in more detail and to give globally more positive feedback when compared to individuals receiving SSCM. Qualitative themes suggest that patients experienced the two treatments differently in terms of characteristics and outcomes., Conclusions: This study highlights the benefits of incorporating qualitative and quantitative data into RCT process evaluations. MANTRA patients were more willing to express their views on treatment and generally felt more positively about this than those receiving SSCM.
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- 2016
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22. The Maudsley Outpatient Study of Treatments for Anorexia Nervosa and Related Conditions (MOSAIC): Comparison of the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with specialist supportive clinical management (SSCM) in outpatients with broadly defined anorexia nervosa: A randomized controlled trial.
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Schmidt U, Magill N, Renwick B, Keyes A, Kenyon M, Dejong H, Lose A, Broadbent H, Loomes R, Yasin H, Watson C, Ghelani S, Bonin EM, Serpell L, Richards L, Johnson-Sabine E, Boughton N, Whitehead L, Beecham J, Treasure J, and Landau S
- Subjects
- Adolescent, Adult, Disease Management, Female, Humans, Male, Outpatients, Patient Acceptance of Health Care, Self Report, Severity of Illness Index, Treatment Outcome, Ambulatory Care, Anorexia Nervosa therapy, Body Mass Index, Psychotherapy methods
- Abstract
Objective: Anorexia nervosa (AN) in adults has poor outcomes, and treatment evidence is limited. This study evaluated the efficacy and acceptability of a novel, targeted psychological therapy for AN (Maudsley Model of Anorexia Nervosa Treatment for Adults; MANTRA) compared with Specialist Supportive Clinical Management (SSCM)., Method: One hundred forty-two outpatients with broadly defined AN (body mass index [BMI] ≤ 18.5 kg/m²) were randomly allocated to receive 20 to 30 weekly sessions (depending on clinical severity) plus add-ons (4 follow-up sessions, optional sessions with dietician and with carers) of MANTRA (n = 72) or SSCM (n = 70). Assessments were administered blind to treatment condition at baseline, 6 months, and 12 months after randomization. The primary outcome was BMI at 12 months. Secondary outcomes included eating disorders symptomatology, other psychopathology, neuro-cognitive and social cognition, and acceptability. Additional service utilization was also assessed. Outcomes were analyzed using linear mixed models., Results: Both treatments resulted in significant improvements in BMI and reductions in eating disorders symptomatology, distress levels, and clinical impairment over time, with no statistically significant difference between groups at either 6 or 12 months. Improvements in neuro-cognitive and social-cognitive measures over time were less consistent. One SSCM patient died. Compared with SSCM, MANTRA patients rated their treatment as significantly more acceptable and credible at 12 months. There was no significant difference between groups in additional service consumption., Conclusions: Both treatments appear to have value as first-line outpatient interventions for patients with broadly defined AN. Longer term outcomes remain to be evaluated., ((c) 2015 APA, all rights reserved).)
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- 2015
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23. Neuro- and social-cognitive clustering highlights distinct profiles in adults with anorexia nervosa.
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Renwick B, Musiat P, Lose A, DeJong H, Broadbent H, Kenyon M, Loomes R, Watson C, Ghelani S, Serpell L, Richards L, Johnson-Sabine E, Boughton N, Treasure J, and Schmidt U
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- Adolescent, Adult, Child Development Disorders, Pervasive psychology, Cluster Analysis, Comorbidity, Female, Humans, Neuropsychological Tests, Young Adult, Anorexia Nervosa psychology, Cognition
- Abstract
Objective: This study aimed to explore the neuro- and social-cognitive profile of a consecutive series of adult outpatients with anorexia nervosa (AN) when compared with widely available age and gender matched historical control data. The relationship between performance profiles, clinical characteristics, service utilization, and treatment adherence was also investigated., Method: Consecutively recruited outpatients with a broad diagnosis of AN (restricting subtype AN-R: n = 44, binge-purge subtype AN-BP: n = 33 or Eating Disorder Not Otherwise Specified-AN subtype EDNOS-AN: n = 23) completed a comprehensive set of neurocognitive (set-shifting, central coherence) and social-cognitive measures (Emotional Theory of Mind). Data were subjected to hierarchical cluster analysis and a discriminant function analysis., Results: Three separate, meaningful clusters emerged. Cluster 1 (n = 45) showed overall average to high average neuro- and social- cognitive performance, Cluster 2 (n = 38) showed mixed performance characterized by distinct strengths and weaknesses, and Cluster 3 (n = 17) showed poor overall performance (Autism Spectrum disorder (ASD) like cluster). The three clusters did not differ in terms of eating disorder symptoms, comorbid features or service utilization and treatment adherence. A discriminant function analysis confirmed that the clusters were best characterized by performance in perseveration and set-shifting measures., Discussion: The findings suggest that considerable neuro- and social-cognitive heterogeneity exists in patients with AN, with a subset showing ASD-like features. The value of this method of profiling in predicting longer term patient outcomes and in guiding development of etiologically targeted treatments remains to be seen., (© 2014 Wiley Periodicals, Inc.)
- Published
- 2015
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24. Improvements in symptoms following neuronavigated repetitive transcranial magnetic stimulation (rTMS) in severe and enduring anorexia nervosa: findings from two case studies.
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McClelland J, Bozhilova N, Nestler S, Campbell IC, Jacob S, Johnson-Sabine E, and Schmidt U
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- Affect, Anorexia Nervosa physiopathology, Female, Humans, Middle Aged, Prefrontal Cortex physiopathology, Treatment Outcome, Young Adult, Anorexia Nervosa therapy, Transcranial Magnetic Stimulation
- Abstract
Background: Advances in the treatment of anorexia nervosa (AN) are most likely to arise from targeted, brain-directed treatments, such as repetitive transcranial magnetic stimulation (rTMS). We describe findings from two individuals with treatment-resistant AN who received 19-20 sessions of neuronavigated, high frequency rTMS, applied to the left dorsolateral prefrontal cortex., Method: Within-session measures assessed changes pre-rTMS, post-rTMS in subjective eating disorder (ED) experiences. Weight, ED symptoms and mood were assessed pre-treatment, post-treatment and at 1 month follow-up., Results: In both cases, there was improvement in ED symptomatology and mood after 19-20 sessions of neuronavigated rTMS, and these changes persisted or continued to improve at follow-up. Within sessions, Patient A demonstrated a consistent reduction in subjective ED experiences, and Patient B a reduction in some ED related experiences., Conclusions: These findings suggest that rTMS has potential as an adjunct to the treatment of AN and deserves further study., (Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.)
- Published
- 2013
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25. The MOSAIC study - comparison of the Maudsley Model of Treatment for Adults with Anorexia Nervosa (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with anorexia nervosa or eating disorder not otherwise specified, anorexia nervosa type: study protocol for a randomized controlled trial.
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Schmidt U, Renwick B, Lose A, Kenyon M, Dejong H, Broadbent H, Loomes R, Watson C, Ghelani S, Serpell L, Richards L, Johnson-Sabine E, Boughton N, Whitehead L, Beecham J, Treasure J, and Landau S
- Subjects
- Adult, Anorexia Nervosa diagnosis, Anorexia Nervosa economics, Anorexia Nervosa psychology, Body Mass Index, Clinical Protocols, Cost-Benefit Analysis, Dietetics, Family Therapy, Feeding and Eating Disorders diagnosis, Feeding and Eating Disorders economics, Feeding and Eating Disorders psychology, Goals, Health Behavior, Health Care Costs, Health Knowledge, Attitudes, Practice, Humans, London, Motivational Interviewing, Nutritional Status, Patient Education as Topic, Sample Size, Time Factors, Treatment Outcome, Weight Gain, Ambulatory Care economics, Anorexia Nervosa therapy, Feeding and Eating Disorders therapy, Mental Health Services economics, Research Design
- Abstract
Background: Anorexia nervosa (AN) is a biologically based serious mental disorder with high levels of mortality and disability, physical and psychological morbidity and impaired quality of life. AN is one of the leading causes of disease burden in terms of years of life lost through death or disability in young women. Psychotherapeutic interventions are the treatment of choice for AN, but the results of psychotherapy depend critically on the stage of the illness. The treatment response in adults with a chronic form of the illness is poor and drop-out from treatment is high. Despite the seriousness of the disorder the evidence-base for psychological treatment of adults with AN is extremely limited and there is no leading treatment. There is therefore an urgent need to develop more effective treatments for adults with AN. The aim of the Maudsley Outpatient Study of Treatments for Anorexia Nervosa and Related Conditions (MOSAIC) is to evaluate the efficacy and cost effectiveness of two outpatient treatments for adults with AN, Specialist Supportive Clinical Management (SSCM) and the Maudsley Model of Treatment for Adults with Anorexia Nervosa (MANTRA)., Methods/design: 138 patients meeting the inclusion criteria are randomly assigned to one of the two treatment groups (MANTRA or SSCM). All participants receive 20 once-weekly individual therapy sessions (with 10 extra weekly sessions for those who are severely ill) and four follow-up sessions with monthly spacing thereafter. There is also optional access to a dietician and extra sessions involving a family member or a close other. Body weight, eating disorder- related symptoms, neurocognitive and psychosocial measures, and service use data are measured during the course of treatment and across a one year follow up period. The primary outcome measure is body mass index (BMI) taken at twelve months after randomization., Discussion: This multi-center study provides a large sample size, broad inclusion criteria and a follow-up period. However, the study has to contend with difficulties directly related to running a large multi-center randomized controlled trial and the psychopathology of AN. These issues are discussed.
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- 2013
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26. An experimental exploration of social problem solving and its associated processes in anorexia nervosa.
- Author
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Sternheim L, Startup H, Pretorius N, Johnson-Sabine E, Schmidt U, and Channon S
- Subjects
- Adolescent, Adult, Anxiety psychology, Body Mass Index, Cognition, Depression psychology, Emotions, Female, Humans, Neuropsychological Tests, Social Perception, Surveys and Questionnaires, Anorexia Nervosa psychology, Interpersonal Relations, Problem Solving, Social Behavior
- Abstract
People with Anorexia Nervosa (AN) have well-documented socio-emotional and neurocognitive impairments. As yet, little is known about their ability to solve problems in social situations, although a link with cognitive avoidance has been suggested. This study explored social problem-solving (SPS), using an experimental task. Secondly, the role of cognitive avoidance in SPS was investigated. Individuals with AN (n=31) and healthy controls (HC; n=39) completed the Social Problem Resolution Task which consists of problem scenarios involving awkward everyday social situations. Participants were asked to generate both the optimal solution and their personal solution. Solutions were rated in terms of how socially sensitive and practically effective they were. AN patients produced relatively poorer personal solutions compared to optimal solutions than HC participants and had higher scores on a measure of cognitive avoidance than the HC group. In AN patients, cognitive avoidance was partially associated with poor SPS. These findings suggest that whilst people with AN have no difficulty in generating socially sensitive and effective solutions to problems, but may have difficulty applying this knowledge to themselves., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
27. Psychosocial barriers to engagement with an eating disorder service: a qualitative analysis of failure to attend.
- Author
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Leavey G, Vallianatou C, Johnson-Sabine E, Rae S, and Gunputh V
- Subjects
- Adult, Humans, Referral and Consultation, Feeding and Eating Disorders psychology, Feeding and Eating Disorders therapy, Health Services Accessibility, Patient Acceptance of Health Care
- Abstract
Patient non-attendance and failure to engage with health services may be costly to the individual in terms of the delays in obtaining appropriate treatment and the unnecessary suffering and discomfort this may entail. Non-attendance is also costly to health services because of administrative and clinical time lost and the opportunity costs of not treating other patients. Patients who have been referred to eating disorders clinics by general practitioners appear to have high rates of non-attendance or dropping out immediately after assessment. The reasons behind their failure to engage are poorly understood. After undertaking a comprehensive audit in a major eating disorder unit in London we undertook a qualitative study of non-attenders in order to obtain the reasons behind non-engagement. We found that while participants tend to open their explanations with practical difficulties (e.g., child-minding) or service- related factors, what commonly emerged from their narratives were profound social-psychological problems and the ambivalence of confronting or losing a relationship with food that was both comforting and debilitating. Some participants described a world of imprisonment which precluded the likelihood of firm engagement with services. We suggest that such people may require better identification and outreach provision.
- Published
- 2011
- Full Text
- View/download PDF
28. Risk factors, correlates, and markers in early-onset bulimia nervosa and EDNOS.
- Author
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Day J, Schmidt U, Collier D, Perkins S, Van den Eynde F, Treasure J, Yi I, Winn S, Robinson P, Murphy R, Keville S, Johnson-Sabine E, Jenkins M, Frost S, Dodge L, Berelowitz M, and Eisler I
- Subjects
- Adolescent, Age of Onset, Female, Humans, Interview, Psychological, Risk Factors, Young Adult, Bulimia Nervosa diagnosis, Feeding and Eating Disorders diagnosis, Menarche physiology
- Abstract
Objective: This study aimed to investigate the specific risk factors, correlates, and markers associated with the development of symptomatology of early-onset BN and subclinical BN., Method: Two semi-structured interviews were used to examine symptomatology and antecedent factors of bulimic symptoms in a sample of British adolescents., Results: Adolescents with early-onset eating pathology were significantly more likely to report an earlier age of menarche than those developing the disorder at the typical age, and were found to have a different pathway of symptom development., Discussion: Increased awareness of this may help identify those particularly at risk for developing an early-onset of eating pathology., (Copyright © 2010 Wiley Periodicals, Inc.)
- Published
- 2011
- Full Text
- View/download PDF
29. Do adolescents with eating disorder not otherwise specified or full-syndrome bulimia nervosa differ in clinical severity, comorbidity, risk factors, treatment outcome or cost?
- Author
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Schmidt U, Lee S, Perkins S, Eisler I, Treasure J, Beecham J, Berelowitz M, Dodge L, Frost S, Jenkins M, Johnson-Sabine E, Keville S, Murphy R, Robinson P, Winn S, and Yi I
- Subjects
- Adolescent, Adult, Comorbidity, Costs and Cost Analysis, Female, Humans, Randomized Controlled Trials as Topic, Risk Factors, Self Care, Self Efficacy, Surveys and Questionnaires, Treatment Outcome, Bulimia Nervosa economics, Bulimia Nervosa epidemiology, Bulimia Nervosa therapy, Family Therapy methods
- Abstract
Objective: We wanted to know whether adolescents with eating disorder not otherwise specified (EDNOS) differ from those with bulimia nervosa (BN) in clinical features, comorbidity, risk factors, treatment outcome or cost., Method: Adolescents with EDNOS (n = 24) or BN (n = 61) took part in a trial of family therapy versus guided self-care. At baseline, eating disorder symptoms, risk factors, and costs were assessed by interview. Patients were reinterviewed at 6 and 12 months., Results: Compared with EDNOS, BN patients binged, vomited and purged significantly more, and were more preoccupied with food. Those with EDNOS had more depression and had more current and childhood obsessive-compulsive disorder. 66.6% of EDNOS versus 27.8% of BN patients were abstinent from bingeing and vomiting at 1 year. Diagnosis did not moderate treatment outcome. Costs did not differ between groups., Conclusion: EDNOS in adolescents is not trivial. It has milder eating disorder symptoms but more comorbidity than BN., ((c) 2008 by Wiley Periodicals, Inc.)
- Published
- 2008
- Full Text
- View/download PDF
30. Predictors of mental health problems and negative caregiving experiences in carers of adolescents with bulimia nervosa.
- Author
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Winn S, Perkins S, Walwyn R, Schmidt U, Eisler I, Treasure J, Berelowitz M, Dodge L, Frost S, Jenkins M, Johnson-Sabine E, Keville S, Murphy R, Robinson P, and Yi I
- Subjects
- Adolescent, Bulimia Nervosa diagnosis, Bulimia Nervosa economics, Bulimia Nervosa therapy, Cognitive Behavioral Therapy economics, Comorbidity, Cost-Benefit Analysis, Expressed Emotion, Family Relations, Family Therapy economics, Feeding and Eating Disorders diagnosis, Feeding and Eating Disorders psychology, Female, Humans, Male, Mental Disorders diagnosis, Personality Inventory, Self Care economics, Statistics as Topic, Bulimia Nervosa psychology, Caregivers psychology, Child Abuse psychology, Mental Disorders psychology
- Abstract
Objective: This exploratory study focuses on the mental health (MH) and caregiving experience of carers of adolescents with Bulimia Nervosa (BN)/Eating Disorder not otherwise specified (EDNOS), aiming to determine: levels of MH problems in carers and if a negative experience of caregiving predicts carer MH status and which factors predict a negative experience of caregiving., Method: Hundred and twelve carers and 68 adolescents with BN/EDNOS completed self-report measures (General Health Questionnaire, Experience of Caregiving Inventory, Level of Expressed Emotion, Self-report Family Inventory, Inventory of Interpersonal Problems)., Results: Over half of the carers reported some MH problems and a minority (5.4%) were experiencing considerable difficulties. A negative experience of caregiving predicted carer MH status. Higher weekly contact hours and patient ratings of expressed emotion (EE) predicted a negative experience of caregiving., Conclusions: Interventions focusing on reducing EE and contact hours could prove beneficial for both patient and caregiver outcomes., (2006 by Wiley Periodicals, Inc.)
- Published
- 2007
- Full Text
- View/download PDF
31. Why do adolescents with bulimia nervosa choose not to involve their parents in treatment?
- Author
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Perkins S, Schmidt U, Eisler I, Treasure J, Yi I, Winn S, Robinson P, Murphy R, Keville S, Johnson-Sabine E, Jenkins M, Frost S, Dodge L, and Berelowitz M
- Subjects
- Adolescent, Adult, Chronic Disease, Cognitive Behavioral Therapy, Comorbidity, Decision Making, Family Relations, Female, Humans, Perception, Risk Factors, Treatment Outcome, Bulimia Nervosa psychology, Bulimia Nervosa therapy, Expressed Emotion, Family Therapy, Parent-Child Relations
- Abstract
Background: Although the use of family therapy for adolescents with anorexia nervosa is well established, there has been limited research into the efficacy of family therapy in adolescents with bulimia nervosa (BN). No previous research has investigated why individuals with BN do or do not involve their parents in treatment. This is an exploratory study aimed at determining whether there are any differences between these individuals in terms of eating disorder symptomatology, psychopathology, familial risk factors, patients' perception of parental expressed emotion (EE) and family functioning., Methods: Participants were 85 adolescents with BN or Eating Disorder Not Otherwise Specified, recruited to a randomised controlled evaluation of the cost-effectiveness of cognitive-behavioural guided self-care vs. family therapy. Participants were interviewed regarding the history of their eating disorder and completed self-report measures., Results: Patients who did not involve their parents in treatment were significantly older, had more chronic eating disorder symptoms, exhibited more co-morbid and impulsive behaviours and rated their mothers higher in EE. However, they did not have more severe eating disorder symptomatology., Conclusions: These preliminary findings, although in need of replication with a larger sample and limited by the attrition rate in some of the self-report measures, indicate that patients who did not involve their parents in treatment may perceive their mothers as having a more blaming and negative attitude towards the patient's illness. Public awareness about BN needs to be raised, focusing on reducing the stigma and negative views attached to this illness.
- Published
- 2005
- Full Text
- View/download PDF
32. Bulimia outcome.
- Author
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Reiss D and Johnson-Sabine E
- Subjects
- Bulimia therapy, Cohort Studies, Female, Follow-Up Studies, Humans, Outcome Assessment, Health Care, Research Design standards, Bulimia diagnosis
- Published
- 1997
33. Bulimia nervosa: 5-year social outcome and relationship to eating pathology.
- Author
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Reiss D and Johnson-Sabine E
- Subjects
- Adolescent, Adult, Body Mass Index, Bulimia psychology, Female, Follow-Up Studies, Humans, Interpersonal Relations, Rehabilitation, Vocational psychology, Social Class, Treatment Outcome, Bulimia rehabilitation, Personality Assessment, Social Adjustment
- Abstract
From an original sample of 50 patients, 32 female patients with bulimia nervosa were followed up for a minimum length of 5 years. Standardized interviews were employed to assess eating attitudes and behavior as well as social status both at entry and at completion of the follow-up period. All participants completed the Social Problem Questionnaire at follow-up. Social outcome was found to parallel eating disorder outcome. Being in a satisfactory stable relationship was associated with good eating disorder outcome. Being in a stable relationship was not related to eating disorder outcome. Good outcome was also associated with higher occupational social class, and having a fulfilling social life and job.
- Published
- 1995
- Full Text
- View/download PDF
34. Hunger strikers.
- Author
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O'Connor A and Johnson-Sabine E
- Subjects
- Female, Humans, Male, Prisoners psychology, Psychotic Disorders epidemiology, Fasting psychology, Human Rights
- Published
- 1988
- Full Text
- View/download PDF
35. Bulimia associated with dysphoria rather than with affective disorder.
- Author
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Johnson-Sabine E
- Subjects
- Humans, Hyperphagia psychology, Imipramine therapeutic use, Mianserin therapeutic use, Mood Disorders drug therapy, Affective Symptoms complications, Feeding and Eating Disorders complications, Hyperphagia complications, Mood Disorders complications
- Published
- 1983
- Full Text
- View/download PDF
36. Abnormal eating attitudes in London schoolgirls--a prospective epidemiological study: factors associated with abnormal response on screening questionnaires.
- Author
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Johnson-Sabine E, Wood K, Patton G, Mann A, and Wakeling A
- Subjects
- Adolescent, Anorexia Nervosa psychology, Body Weight, Bulimia psychology, Diet, Reducing psychology, Female, Humans, London, Obesity psychology, Risk Factors, Attitude, Feeding and Eating Disorders psychology, Psychological Tests
- Abstract
One thousand and ten unselected London state schoolgirls were screened by questionnaire to identify an 'at risk' cohort displaying abnormal eating attitudes and two control cohorts, one with probable general psychiatric morbidity, one without. Members of all cohorts were assessed at interview for the presence of eating disorder and for putative risk factors implicated in the development of anorexia nervosa. A prevalence rate of 0.99% was detected for clinical eating disorder and 1.78% for the partial syndrome of eating disorder. Factors specifically associated with abnormal eating attitudes were identified, in particular, current or past overweight, history of amenorrhoea and perceived stress in school and social life. Some commonly accepted risk factors for eating disorders were discovered to be associations with general psychiatric morbidity. These were perceived parental pressure to eat more, taking exercise to lose weight, perceived stress at home and reporting a family history of anxiety or depression. Other well reported putative risk factors for eating disorder, including social class, birth order, age at menarche, obsessional personality and weight related career choice were not associated specifically with abnormal eating attitudes in schoolgirls. These findings represent cross-sectional data at entry into a prospective epidemiological study.
- Published
- 1988
- Full Text
- View/download PDF
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