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4. Alternative Sources of Cautery in Thyroid Surgery and the Risk of Recurrent Laryngeal Nerve Injury: A Retrospective, Risk-Adjusted Analysis From the National Surgical Quality Improvement Program.

Author

Best, Corliss A. E., Hussain, Jumana, and Johnson-Obaseki, Stephanie

Subjects
RISK assessment, CAUTERY, LARYNGEAL nerves, RECURRENT laryngeal nerve, MULTIPLE regression analysis, RETROSPECTIVE studies, LONGITUDINAL method, QUALITY assurance, POSTOPERATIVE period, THYROIDECTOMY
Abstract

Objectives: A risk-adjusted analysis was completed using data from the National Surgical Quality Improvement Program (NSQIP) to compare the rates of recurrent laryngeal nerve injury in thyroid surgery using traditional versus alternative sources of cautery (defined as Harmonic Scalpel© and LigaSure©). Methods: A retrospective cohort study was completed using the NSQIP database on adult patients who underwent total thyroidectomy, subtotal thyroidectomy, or completion thyroidectomy between 2016 and 2018. The primary outcome measure was recurrent laryngeal nerve injury. The exposure variable was use of conventional or alternative sources of cautery. Multivariable linear and logistic regression analyses were performed to control for potentially confounding variables. Results: A total of 13,961 cases were analyzed; 9450 used alternative sources of cautery compared to 4511 where traditional cautery was used. There was no significant difference in rates of postoperative recurrent laryngeal nerve injury between the 2 sources of cautery compared. Conclusions: Risk of recurrent laryngeal nerve injury should not be a factor when choosing method of cautery for thyroid surgery. Therefore, other factors like cost-effectiveness can be considered. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Tumor volumes in T3 supraglottic cancers treated with radiotherapy in the modern era: A study of the Canadian Head & Neck Collaborative Research Initiative

Author

Malik, Nauman H., primary, Fu, Rui, additional, Hainc, Nicolin, additional, Noel, Christopher W., additional, de Almeida, John R., additional, Hosni, Ali, additional, Huang, Shao Hui, additional, Yu, Eugene, additional, Dzioba, Agnieszka, additional, Leung, Andrew, additional, Mangat, Arvindpaul, additional, MacNeil, Danielle, additional, Nichols, Anthony C., additional, Hiremath, Shivaprakash B., additional, Chakraborty, Santanu, additional, Jooya, Alborz, additional, Gaudet, Marc, additional, Johnson‐Obaseki, Stephanie, additional, Whelan, Jonathan, additional, Forghani, Reza, additional, Hier, Michael P., additional, Morand, Grégoire, additional, Sultanem, Khalil, additional, Dort, Joseph, additional, Lysack, John, additional, Matthews, Wayne, additional, Nakoneshny, Steven, additional, Gill, Gia, additional, Globerman, Adam, additional, Kerr, Paul, additional, Maralani, Pejman, additional, Karam, Irene, additional, and Eskander, Antoine, additional

Published
2023
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6. Survival of Patients With Head and Neck Merkel Cell Cancer

Author

Nayak, Ameeta Lubina, primary, Pickett, Arthur Travis, additional, Delisle, Megan, additional, Dingley, Brittany, additional, Mallick, Ranjeeta, additional, Hamilton, Trevor, additional, Stuart, Heather, additional, Talbot, Martha, additional, McKinnon, Gregory, additional, Jost, Evan, additional, Thiboutot, Eva, additional, Francescutti, Valerie, additional, Samman, Sal, additional, Easson, Alexandra, additional, Schellenberg, Angela, additional, Merchant, Shaila, additional, La, Julie, additional, Vanderbeck, Kaitlin, additional, Wright, Frances, additional, Berger-Richardson, David, additional, Hebbard, Pamela, additional, Hershorn, Olivia, additional, Younan, Rami, additional, Patocskai, Erica, additional, Rodriguez-Qizilbash, Samuel, additional, Meguerditichian, Ari, additional, Tchuente, Vanina, additional, Kazandjian, Suzanne, additional, Mathieson, Alex, additional, Hossain, Farisa, additional, Hetu, Jessika, additional, Corsten, Martin, additional, Tohmé, Angelina, additional, Nessim, Carolyn, additional, and Johnson-Obaseki, Stephanie, additional

Published
2023
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9. Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial

Author

Nichols, Anthony C, Theurer, Julie, Prisman, Eitan, Read, Nancy, Berthelet, Eric, Tran, Eric, Fung, Kevin, de Almeida, John R, Bayley, Andrew, Goldstein, David P, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S Danielle, Winquist, Eric, Hammond, J Alex, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Chen, Jeff, Corsten, Martin, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Parker, Christina, Wehrli, Bret, Kwan, Keith, and Palma, David A

Published
2019
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10. Tumor volumes in T3 supraglottic cancers treated with radiotherapy in the modern era: A study of the Canadian Head & Neck Collaborative Research Initiative.

Author

Malik, Nauman H., Fu, Rui, Hainc, Nicolin, Noel, Christopher W., de Almeida, John R., Hosni, Ali, Huang, Shao Hui, Yu, Eugene, Dzioba, Agnieszka, Leung, Andrew, Mangat, Arvindpaul, MacNeil, Danielle, Nichols, Anthony C., Hiremath, Shivaprakash B., Chakraborty, Santanu, Jooya, Alborz, Gaudet, Marc, Johnson‐Obaseki, Stephanie, Whelan, Jonathan, and Forghani, Reza

Subjects
LARYNGEAL cancer, CANCER radiotherapy, HEAD & neck cancer, INTENSITY modulated radiotherapy, TUMORS, PROGRESSION-free survival
Abstract

Purpose: To evaluate the association of primary tumor volume (TV) with overall survival (OS) and disease‐free survival (DFS) in T3 N0‐3M0 supraglottic cancers treated with intensity‐modulated radiotherapy (IMRT). Methods: This was a retrospective cohort study involving 239 patients diagnosed with T3 N0‐3M0 supraglottic cancers between 2002 and 2018 from seven regional cancer centers in Canada. Clinical data were obtained from the patient records. Supraglottic TV was measured by neuroradiologists on diagnostic imaging. Kaplan–Meier method was used for survival probabilities, and a restricted cubic spline Cox proportional hazards regression analysis was used to analyze TV associations with OS and DFS. Results: Mean (SD) of participants was 65.2 (9.4) years; 176 (73.6%) participants were male. 90 (38%) were N0, and 151 (64%) received concurrent systemic therapy. Mean TV (SD) was 11.37 (12.11) cm3. With mean follow up (SD) of 3.28 (2.60) years, 2‐year OS was 72.7% (95% CI 66.9%–78.9%) and DFS was 53.6% (47.4%–60.6%). Increasing TV was associated (per cm3 increase) with worse OS (HR, 1.01, 95% CI 1.00–1.02, p < 0.01) and DFS (HR, 1.01, 95% CI 1.00–1.02, p = 0.02). Conclusions: Increasing primary tumor volume is associated with worse OS and DFS in T3 supraglottic cancers treated with IMRT, with no clear threshold. The findings suggest that patients with larger tumors and poor baseline laryngeal function may benefit from upfront laryngectomy with adjuvant radiotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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11. 212 Association of Tumour Volume with Survival in T3 Supraglottic Cancers Managed with Radiotherapy

Author

Malik, Nauman, primary, Hier, Michael, additional, Morand, Grégoire, additional, Fu, Rui, additional, Hainc, Nicolin, additional, Sophie Huang, Shao Hui, additional, Yu, Eugene, additional, Johnson-Obaseki, Stephanie, additional, Whelan, Jonathan, additional, Lysack, John, additional, Matthews, Wayne, additional, Globerman, Adam, additional, Kerr, Paul, additional, Maralani, Pejman, additional, Karam, Irene, additional, and Eskander, Antoine, additional

Published
2023
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12. Comparison of socio-economic determinants of COVID-19 testing and positivity in Canada: A multi-provincial analysis

Author

Antonova, Lilia, primary, Somayaji, Chandy, additional, Cameron, Jillian, additional, Sirski, Monica, additional, Sundaram, Maria E., additional, McDonald, James Ted, additional, Mishra, Sharmistha, additional, Kwong, Jeffrey C., additional, Katz, Alan, additional, Baral, Stefan, additional, Caulley, Lisa, additional, Calzavara, Andrew, additional, Corsten, Martin, additional, and Johnson-Obaseki, Stephanie, additional

Published
2023
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15. Data from Customized Viral Immunotherapy for HPV-Associated Cancer

Author

Atherton, Matthew J., primary, Stephenson, Kyle B., primary, Pol, Jonathan, primary, Wang, Fuan, primary, Lefebvre, Charles, primary, Stojdl, David F., primary, Nikota, Jake K., primary, Dvorkin-Gheva, Anna, primary, Nguyen, Andrew, primary, Chen, Lan, primary, Johnson-Obaseki, Stephanie, primary, Villeneuve, Patrick J., primary, Diallo, Jean-Simon, primary, Dimitroulakos, Jim, primary, Wan, Yonghong, primary, and Lichty, Brian D., primary

Published
2023
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17. Supplementary figures 1-7 from Customized Viral Immunotherapy for HPV-Associated Cancer

Author

Atherton, Matthew J., primary, Stephenson, Kyle B., primary, Pol, Jonathan, primary, Wang, Fuan, primary, Lefebvre, Charles, primary, Stojdl, David F., primary, Nikota, Jake K., primary, Dvorkin-Gheva, Anna, primary, Nguyen, Andrew, primary, Chen, Lan, primary, Johnson-Obaseki, Stephanie, primary, Villeneuve, Patrick J., primary, Diallo, Jean-Simon, primary, Dimitroulakos, Jim, primary, Wan, Yonghong, primary, and Lichty, Brian D., primary

Published
2023
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19. Oncologic Safety of Close Margins in Patients With Low- to Intermediate-Grade Major Salivary Gland Carcinoma

Author

Sajisevi, Mirabelle, Nguyen, Kenny, Callas, Peter, Holcomb, Andrew J., Vural, Emre, Davis, Kyle P., Thomas, Carissa M., Plonowska-Hirschfeld, Karolina A., Stein, John S., Eskander, Antoine, Kakarala, Kiran, Enepekides, Danny J., Hier, Michael P., Ryan, William R., Asarkar, Ameya A., Aulet, Ricardo, Bell, Rebecca K., Blasco, Michael A., Bowmaster, Vanessa B., Burruss, Clayton P., Chung, Jeffson, Chan, Kimberly, Chang, Brent A., Coffey, Charles S., Cognetti, David M., Cooper, Dylan J., Cordero, Joehassin, Donovan, John, Du, Yue (Jennifer), Dundar, Yusuf, Dedivitis, Rogerio A., Edwards, Heather A., Erovic, Boban M., Feinberg, Philip A., Garvey, Emily A., Goldstein, David P., Goodman, Joseph F., Goulart, Rafael N., Goyal, Neerav, Grasl, Stefan, Giurintano, Jonathan P., Gupta, Nikita, Habib, Andy M., Hackman, Trevor G., Hara, Jared H., Henson, Christina, Hinni, Michael L., Hua, Nadia, Johnson-Obaseki, Stephanie, Juloori, Aditya, Kalman, Noah S., Kejner, Alexandra E., Khaja, Sobia F., Ku, Jamie A., Lambert, Arnaud, Luu, Bao K., Magliocca, Kelly R., dos Santos, Luiz R. Medina, Michael, Cara, Miles, Brett A., de Melo, Giulianno Molina, Moore, Michael G., Morand, Gregoire B., Moura, Kauê, Mukdad, Laith, Noroozi, Hesameddin, Patel, Rusha, Paydarfar, Joseph A., Sadeghi, Nader, Savaria, Fabrice N., Schmitt, Nicole C., Shapiro, Justin, Shaver, Timothy B., Stoeckli, Sandro J., St. John, Maie, Stokes, William Alvo, Sulibhavi, Anita, Tasoulas, Jason, Vendra, Varun, Vinh, Daniel B., Virgen, Celina G., Wooten, Christian, Woody, Neil M., and Young, Geoffrey D.

Abstract

IMPORTANCE: Postoperative radiation therapy for close surgical margins in low- to intermediate-grade salivary carcinomas lacks multi-institutional supportive evidence. OBJECTIVE: To evaluate the oncologic outcomes for low- and intermediate-grade salivary carcinomas with close and positive margins. DESIGN, SETTING, AND PARTICIPANTS: The American Head and Neck Society Salivary Gland Section conducted a retrospective cohort study from 2010 to 2019 at 41 centers. Margins were classified as R0 (negative), R1 (microscopically positive), or R2 (macroscopically positive). R0 margins were subclassified into clear (>1 mm) or close (≤1 mm). Data analysis was performed from June to October 2023. MAIN OUTCOMES AND MEASURES: Main outcomes were risk factors for local recurrence. RESULTS: A total of 865 patients (median [IQR] age at surgery, 56 [43-66] years; 553 female individuals [64%] and 312 male individuals [36%]) were included. Of these, 801 (93%) had parotid carcinoma and 64 (7%) had submandibular gland carcinoma, and 748 (86%) had low-grade tumors and 117 (14%) had intermediate-grade tumors, with the following surgical margins: R0 in 673 (78%), R1 in 168 (19%), and R2 in 24 (3%). Close margins were found in 395 of 499 patients with R0 margins (79%), for whom margin distances were measured. A total of 305 patients (35%) underwent postoperative radiation therapy. Of all 865 patients, 35 (4%) had local recurrence with a median (IQR) follow-up of 35.3 (13.9-59.1) months. In patients with close margins as the sole risk factor for recurrence, the local recurrence rates were similar between those who underwent postoperative radiation therapy (0 of 46) or observation (4 of 165 [2%]). Patients with clear margins (n = 104) had no recurrences. The local recurrence rate in patients with R1 or R2 margins was better in those irradiated (2 of 128 [2%]) compared to observed (13 of 64 [20%]) (hazard ratio [HR], 0.05; 95% CI, 0.01-0.24). Multivariable analysis for local recurrence found the following independent factors: age at diagnosis (HR for a 10-year increase in age, 1.33; 95% CI, 1.06-1.67), R1 vs R0 (HR, 5.21; 95% CI, 2.58-10.54), lymphovascular invasion (HR, 4.47; 95% CI, 1.43-13.99), and postoperative radiation therapy (HR, 0.10; 95% CI, 0.04-0.29). The 3-year local recurrence-free survivals for the study population were 96% vs 97% in the close margin group. CONCLUSIONS AND RELEVANCE: In this cohort study of patients with low- and intermediate-grade major salivary gland carcinoma, postoperative radiation therapy for positive margins was associated with decreased risk of local recurrence. In isolation from other risk factors for local recurrence, select patients with close surgical margins (≤1 mm) may safely be considered for observation.

Published
2024
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21. Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony C., Lang, Pencilla, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, de Almeida, John R., Bayley, Andrew, Goldstein, David P., Eskander, Antoine, Husain, Zain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S. Danielle, Mendez, Adrian, Winquist, Eric, Read, Nancy, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Rajaraman, Murali, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, Matthews, T. Wayne, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David A.

Published
2020
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23. Cost-effectiveness of postoperative imaging surveillance strategies for nonfunctional pituitary adenomas after resection with curative intent.

Author

Caulley, Lisa, Dijk, Stijntje W., Krijkamp, Eline, Dong, Selina X., Alkherayf, Fahad, Amrani, Liza, Doyle, Mary-Anne, Eid, Anas, Johnson-Obaseki, Stephanie, Khoury, Michel, Malcolm, Janine, Mavedatnia, Dorsa, Sahlollbey, Nick, Schramm, David, Whelan, Jonathan, Thavorn, Kednapa, Kilty, Shaun, and Hunink, Myriam G. M.

Published
2023
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24. Oncologic Significance of Therapeutic Delays in Patients With Oral Cavity Cancer.

Author

Dayan, Gabriel S., Bahig, Houda, Johnson-Obaseki, Stephanie, Eskander, Antoine, Hong, Xinyuan, Chandarana, Shamir, de Almeida, John R., Nichols, Anthony C., Hier, Michael, Belzile, Mathieu, Gaudet, Marc, Dort, Joseph, Matthews, T. Wayne, Hart, Robert, Goldstein, David P., Yao, Christopher M. K. L., Hosni, Ali, MacNeil, Danielle, Fowler, James, and Higgins, Kevin

Published
2023
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25. The protective role of postoperative radiation therapy in low and intermediate grade major salivary gland malignancies: A study of the Canadian Head and Neck Collaborative Research Initiative.

Author

Morand, Grégoire B., Eskander, Antoine, Fu, Rui, de Almeida, John, Goldstein, David, Noroozi, Hesameddin, Hosni, Ali, Seikaly, Hadi, Tabet, Paul, Pyne, Justin M., Matthews, T. Wayne, Dort, Joseph, Nakoneshny, Steve, Christopoulos, Apostolos, Bahig, Houda, Johnson‐Obaseki, Stephanie, Hua, Nadia, Gaudet, Marc, Jooya, Alborz, and Nichols, Anthony

Subjects
RADIOTHERAPY, SALIVARY glands, SALIVARY gland cancer, SUBMANDIBULAR gland, PAROTID glands, MUCOEPIDERMOID carcinoma
Abstract

Background: The objective of this study was to examine the utility of postoperative radiation for low and intermediate grade cancers of the parotid and submandibular glands. Methods: The authors conducted a retrospective, Canadian‐led, international, multi‐institutional analysis of a patient cohort with low or intermediate grade salivary gland cancer of the parotid or submandibular gland who were treated from 2010 until 2020 with or without postoperative radiation therapy. A multivariable, marginal Cox proportional hazards regression analysis was performed to quantify the association between locoregional recurrence (LRR) and receipt of postoperative radiation therapy while accounting for patient‐level factors and the clustering of patients by institution. Results: In total, 621 patients across 14 tertiary care centers were included in the study; of these, 309 patients (49.8%) received postoperative radiation therapy. Tumor histologies included 182 (29.3%) acinic cell carcinomas, 312 (50.2%) mucoepidermoid carcinomas, and 137 (20.5%) other low or intermediate grade primary salivary gland carcinomas. Kaplan–Meier LRR‐free survival at 10 years was 89.0% (95% confidence interval [CI], 84.9%–93.3%). In multivariable Cox regression analysis, postoperative radiation therapy was independently associated with a lower hazard of LRR (adjusted hazard ratio, 0.53; 95% CI, 0.29–0.97). The multivariable model estimated that the marginal probability of LRR within 10 years was 15.4% without radiation and 8.8% with radiation. The number needed to treat was 16 patients (95% CI, 14–18 patients). Radiation therapy had no benefit in patients who had early stage, low‐grade salivary gland cancer without evidence of nodal disease and negative margins. Conclusions: Postoperative radiation therapy may reduce LLR in some low and intermediate grade salivary gland cancers with adverse features, but it had no benefit in patients who had early stage, low‐grade salivary gland cancer with negative margins. This was a retrospective, Canadian‐led, international, multi‐institutional analysis of 621 patients with low or intermediate grade salivary gland cancer of the parotid or submandibular gland, of whom 309 patients (49.8%) received postoperative radiation therapy. In regression analysis, postoperative radiation therapy was an independent protective factor against locoregional recurrence with an adjusted hazard ratio of 0.53 (95% confidence interval, 0.29–0.97). [ABSTRACT FROM AUTHOR]

Published
2023
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27. Association of Primary Tumor Volume With Survival in Patients With T3 Glottic Cancer Treated With Radiotherapy

Author

Malik, Nauman H., primary, Fu, Rui, additional, Hainc, Nicolin, additional, Noel, Christopher W., additional, de Almeida, John R., additional, Hosni, Ali, additional, Hui Huang, Shao, additional, Yu, Eugene, additional, Dzioba, Agnieszka, additional, Leung, Andrew, additional, Mangat, Arvindpaul, additional, MacNeil, Danielle, additional, Nichols, Anthony C., additional, Hiremath, Shivaprakash B., additional, Chakraborty, Santanu, additional, Jooya, Alboorz, additional, Gaudet, Marc, additional, Johnson-Obaseki, Stephanie, additional, Whelan, Jonathan, additional, Forghani, Reza, additional, Hier, Michael P., additional, Morand, Grégoire, additional, Sultanem, Khalil, additional, Dort, Joseph, additional, Lysack, John, additional, Matthews, Wayne, additional, Nakoneshny, Steven, additional, Gill, Gia, additional, Globerman, Adam, additional, Kerr, Paul, additional, Maralani, Pejman, additional, Karam, Irene, additional, and Eskander, Antoine, additional

Published
2023
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29. Effectiveness of stop smoking interventions among adults: protocol for an overview of systematic reviews and an updated systematic review

Author

Hersi, Mona, Traversy, Gregory, Thombs, Brett D., Beck, Andrew, Skidmore, Becky, Groulx, Stéphane, Lang, Eddy, Reynolds, Donna L., Wilson, Brenda, Bernstein, Steven L., Selby, Peter, Johnson-Obaseki, Stephanie, Manuel, Douglas, Pakhale, Smita, Presseau, Justin, Courage, Susan, Hutton, Brian, Shea, Beverley J., Welch, Vivian, Morrow, Matt, Little, Julian, and Stevens, Adrienne

Published
2019
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30. Post-operative surveillance for somatotroph, lactotroph and non-functional pituitary adenomas after curative resection: a systematic review

Author

Caulley, Lisa, primary, Whelan, Jonathan, additional, Khoury, Michel, additional, Mavedatnia, Dorsa, additional, Sahlollbey, Nick, additional, Amrani, Lisa, additional, Eid, Anas, additional, Doyle, Mary-Anne, additional, Malcolm, Janine, additional, Alkherayf, Fahad, additional, Ramsay, Tim, additional, Moher, David, additional, Johnson-Obaseki, Stephanie, additional, Schramm, David, additional, Hunink, Myriam G. M., additional, and Kilty, Shaun J., additional

Published
2022
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31. Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study

Author

Hua, Nadia, primary, Corsten, Martin, additional, Bello, Alexander, additional, Bhatt, Maala, additional, Milwid, Rachael, additional, Champredon, David, additional, Turgeon, Patricia, additional, Zemek, Roger, additional, Dawson, Lauren, additional, Mitsakakis, Nicholas, additional, Webster, Richard, additional, Caulley, Lisa, additional, Angel, Jonathan B., additional, Bastien, Nathalie, additional, Poliquin, Guillaume, additional, and Johnson-Obaseki, Stephanie, additional

Published
2022
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32. Effectiveness of stop smoking interventions among adults: an overview of systematic reviews and an updated systematic review

Author

Beck, Andrew, Bennett, Alexandria, Shaver, Nicole, Hersi, Mona, Skidmore, Becky, Johnson-Obaseki, Stephanie, Manuel, Douglas, Pakhale, Smita, Presseau, Justin, Hutton, Brian, Shea, Bev, Welch, Vivian, Little, Julian, and Stevens, Adrienne

Subjects
Knowledge Synthesis and Application Unit, e-cigarettes, SEPH, Knowledge Synthesis Group, tobacco, OHRI, smoking, School of Epidemiology and Public Health, KSAU, overview of reviews, primary care, cessation, KSG, CTFPHC, systematic review, electronic cigarettes, University of Ottawa, adults, guideline, stop smoking
Abstract

The aim of this overview of reviews and systematic review update is to identify evidence on the effectiveness of stop smoking interventions for adults for the Canadian Task Force on Preventive Health Care (CTFPHC) and their stop smoking guideline for primary care providers.

Published
2022
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37. Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Author

Palma, David A., primary, Prisman, Eitan, additional, Berthelet, Eric, additional, Tran, Eric, additional, Hamilton, Sarah, additional, Wu, Jonn, additional, Eskander, Antoine, additional, Higgins, Kevin, additional, Karam, Irene, additional, Poon, Ian, additional, Husain, Zain, additional, Enepekides, Danny, additional, Hier, Michael, additional, Sultanem, Khalil, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Johnson-Obaseki, Stephanie, additional, Odell, Michael, additional, Bayley, Andrew, additional, Dowthwaite, Samuel, additional, Jackson, James E., additional, Dzienis, Marcin, additional, O’Neil, John, additional, Chandarana, Shamir, additional, Banerjee, Robyn, additional, Hart, Robert, additional, Chung, Jeffson, additional, Tenenholtz, Todd, additional, Krishnan, Suren, additional, Le, Hien, additional, Yoo, John, additional, Mendez, Adrian, additional, Winquist, Eric, additional, Kuruvilla, Sara, additional, Stewart, Paul, additional, Warner, Andrew, additional, Mitchell, Sylvia, additional, Chen, Jeff, additional, Parker, Christina, additional, Wehrli, Bret, additional, Kwan, Keith, additional, Theurer, Julie, additional, Sathya, Jinka, additional, Hammond, J. Alex, additional, Read, Nancy, additional, Venkatesan, Varagur, additional, MacNeil, S. Danielle, additional, Fung, Kevin, additional, and Nichols, Anthony C., additional

Published
2022
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39. Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial

Author

Nichols, Anthony C., primary, Theurer, Julie, additional, Prisman, Eitan, additional, Read, Nancy, additional, Berthelet, Eric, additional, Tran, Eric, additional, Fung, Kevin, additional, de Almeida, John R., additional, Bayley, Andrew, additional, Goldstein, David P., additional, Hier, Michael, additional, Sultanem, Khalil, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Krishnan, Suren, additional, Le, Hien, additional, Yoo, John, additional, MacNeil, S. Danielle, additional, Winquist, Eric, additional, Hammond, J. Alex, additional, Venkatesan, Varagur, additional, Kuruvilla, Sara, additional, Warner, Andrew, additional, Mitchell, Sylvia, additional, Chen, Jeff, additional, Corsten, Martin, additional, Johnson-Obaseki, Stephanie, additional, Odell, Michael, additional, Parker, Christina, additional, Wehrli, Bret, additional, Kwan, Keith, additional, and Palma, David A., additional

Published
2022
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43. Salivary HPV Persistence Following Treatment of Oropharyngeal Squamous Cell Carcinoma.

Author

Quimby, Alexandra E., Lagiou, Pagona, Purgina, Bibiana, Corsten, Martin, and Johnson-Obaseki, Stephanie

Subjects
DNA analysis, PAPILLOMAVIRUSES, RESEARCH, PILOT projects, REVERSE transcriptase polymerase chain reaction, ACADEMIC medical centers, SPECIALTY hospitals, SALIVA, CHRONIC diseases, CROSS-sectional method, MULTIPLE regression analysis, OROPHARYNGEAL cancer, CANCER relapse, INFECTION, CANCER patients, CANCER treatment, PAPILLOMAVIRUS diseases, CHI-squared test, DESCRIPTIVE statistics, DISEASE prevalence, STATISTICAL sampling, DATA analysis software, SQUAMOUS cell carcinoma, LONGITUDINAL method, PROPORTIONAL hazards models, DISEASE risk factors
Abstract

Objective: To determine the persistence of human papillomavirus (HPV) infection following treatment of HPV-positive oropharyngeal squamous cell carcinoma (HPV + OPSCC). Methods: A cross-sectional study was undertaken at The Ottawa Hospital (Ottawa, ON, Canada), a tertiary academic hospital and regional cancer center. Adult patients who were diagnosed with HPV + OPSCC between the years of 2014 and 2016 and treated with curative intent, and who were alive and willing to consent were eligible for inclusion. A saliva assay was used to test for the presence of HPV DNA in a random sample of patients. qPCR was used to amplify DNA from saliva samples. Results: Saliva samples were obtained from 69 patients previously treated with HPV + OPSCC. All patients had a minimum of 2 years of follow-up. 5 patients tested positive for HPV: 2 were positive for HPV-16, 2 for HPV-18, and 1 "other" HPV type. No patient in our study cohort had suffered recurrence post-treatment. Conclusions: This study is the first to demonstrate the prevalence of persistent oncogenic HPV DNA in saliva following treatment for HPV + OPSCC. This prevalence appears to be low, despite the fact that persistent HPV infection is a precursor for the development of HPV + OPSCC. This finding raises questions about what factors influence the clearance or persistence of HPV DNA in saliva after treatment for HPV + OPSCC, and may add to our understanding about the longitudinal effects of HPV infection in these cancers. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Treatment Choices in Managing Bethesda III and IV Thyroid Nodules: A Canadian Multi-institutional Study

Author

Kuta, Victoria, primary, Forner, David, additional, Azzi, Jason, additional, Curry, Dennis, additional, Noel, Christopher W., additional, Munroe, Kelti, additional, Bullock, Martin, additional, McDonald, Ted, additional, Taylor, S. Mark, additional, Rigby, Matthew H., additional, Trites, Jonathan, additional, Johnson-Obaseki, Stephanie, additional, and Corsten, Martin J., additional

Published
2021
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45. Salivary Detection of COVID-19

Author

Caulley, Lisa, primary, Corsten, Martin, additional, Eapen, Libni, additional, Whelan, Jonathan, additional, Angel, Jonathan B., additional, Antonation, Kym, additional, Bastien, Nathalie, additional, Poliquin, Guillaume, additional, and Johnson-Obaseki, Stephanie, additional

Published
2021
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46. Additional file 5 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 5. Study Information and Informed Consent Form.

Published
2020
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47. Additional file 4 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Subjects
ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES
Abstract

Additional file 4. Lab Guidelines.

Published
2020
Full Text
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48. Additional file 6 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 6. World Health Organization Trial Registration Dataset.

Published
2020
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49. Additional file 1 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 1. Treatment Planning Guidelines.

Published
2020
Full Text
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50. Additional file 2 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 2. Surgical Credentialling Form.

Published
2020
Full Text
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