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24 results on '"Johnson, Michelle D."'

7. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

Author

Aitman, Timothy J., Dong, Rong, Vyse, Timothy J., Norsworthy, Penny J., Johnson, Michelle D., Smith, Jennifer, Mangion, Jonathan, Roberton-Lowe, Cheri, Marshall, Amy J., Petretto, Enrico, Hodges, Matthew D., Bhangal, Gurjeet, Patel, Sheetal G., Sheehan-Rooney, Kelly, Duda, Mark, Cook, Paul R., Evans, David J., Domin, Jan, Flint, Jonathan, Boyle, Joseph J., Pusey, Charles D., and Cook, H. Terence

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Timothy J. Aitman (corresponding author) [1]; Rong Dong [1, 6]; Timothy J. Vyse [2, 6]; Penny J. Norsworthy [1, 6]; Michelle D. Johnson [1]; Jennifer Smith [3]; Jonathan Mangion [...]

Published
2006
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9. Mutations in ANKH cause chondrocalcinosis

Author

Pendleton, Adrian, Johnson, Michelle D., Hughes, Anne, Gurley, Kyle A., Ho, Andrew M., Doherty, Michael, Dixey, Josh, Gillet, Pierre, Loeuille, Damien, McGrath, Rodney, Reginato, Antonio, Shiang, Rita, Wright, Gary, Netter, Patrick, Williams, Charlene, and Kingsley, David M.

Subjects
Human genetics -- Research, Gene mutations -- Physiological aspects, Calcium, Dietary -- Physiological aspects, Articular cartilage -- Physiological aspects, Metabolic diseases -- Health aspects, Metabolic diseases -- Complications, Chondrocalcinosis -- Genetic aspects, Chondrocalcinosis -- Research, Chondrocalcinosis -- Causes of, Biological sciences
Published
2002

13. Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia

Author

Gong, Sungsam, Sovio, Ulla, Aye, Irving L.M.H., Gaccioli, Francesca, Dopierala, Justyna, Johnson, Michelle D., Wood, Angela M., Cook, Emma, Jenkins, Benjamin J., Koulman, Albert, Casero, Robert A., Constância, Miguel, Charnock-Jones, D. Stephen, Smith, Gordon C.S., Gong, Sung [0000-0001-5796-4423], Sovio, Ulla [0000-0002-0799-1105], Aye, Irving [0000-0003-3400-5005], Gaccioli, Francesca [0000-0001-7178-8921], Wood, Angela [0000-0002-7937-304X], Koulman, Albert [0000-0001-9998-051X], Charnock-Jones, Stephen [0000-0002-2936-4890], Smith, Gordon [0000-0003-2124-0997], and Apollo - University of Cambridge Repository

Subjects
Male, Cell Survival, Placenta, Spermine Synthase, Gestational Age, Obstetrics/gynecology, Risk Assessment, Ultrasonography, Prenatal, Fetal Development, Sex Factors, Pre-Eclampsia, Genes, X-Linked, Pregnancy, Polyamines, Humans, Prospective Studies, reproductive and urinary physiology, Expression profiling, Reproductive Biology, Fetal Growth Retardation, Sequence Analysis, RNA, United Kingdom, Trophoblasts, Pregnancy Complications, Gene Expression Regulation, embryonic structures, Female, Spermine, Transcriptome, Research Article
Abstract

Preeclampsia and fetal growth restriction (FGR) are major causes of the more than 5 million perinatal and infant deaths occurring globally each year, and both are associated with placental dysfunction. The risk of perinatal and infant death is greater in males, but the mechanisms are unclear. We studied data and biological samples from the Pregnancy Outcome Prediction (POP) study, a prospective cohort study that followed 4,212 women having first pregnancies from their dating ultrasound scan through delivery. We tested the hypothesis that fetal sex would be associated with altered placental function using multiomic and targeted analyses. We found that spermine synthase (SMS) escapes X-chromosome inactivation (XCI) in the placenta and is expressed at lower levels in male primary trophoblast cells, and male cells were more sensitive to polyamine depletion. The spermine metabolite N1,N12-diacetylspermine (DiAcSpm) was higher in the female placenta and in the serum of women pregnant with a female fetus. Higher maternal serum levels of DiAcSpm increased the risk of preeclampsia but decreased the risk of FGR. To our knowledge, DiAcSpm is the first maternal biomarker to demonstrate opposite associations with preeclampsia and FGR, and this is the first evidence to implicate polyamine metabolism in sex-related differences in placentally related complications of human pregnancy., The human female placenta has enhanced spermine synthesis which protects fetal growth but predisposes to preeclampsia.

Published
2018

16. The genome sequence of the spontaneously hypertensive rat: analysis and functional significance

Author

Atanur, Santosh S., Birol, ?nanc, Guryev, Victor, Hirst, Martin, Hummel, Oliver, Morrissey, Catherine, Behmoaras, Jacques, Fernandez-Suarez, Xose M., Johnson, Michelle D., McLaren, William M., Patone, Giannino, Petretto, Enrico, Plessy, Charles, Rockland, Kathleen S., Rockland, Charles, Saar, Kathrin, Zhao, Yongjun, Carninci, Piero, Flicek, Paul, Kurtz, Ted, Cuppen, Edwin, Pravenec, Michal, Hubner, Norbert, Jones, Steven J.M., Birney, Ewan, and Aitman, Timothy J.

Subjects
Genetically modified mice -- Usage, Single nucleotide polymorphisms -- Analysis, Hypertension -- Genetic aspects, Hypertension -- Research, Quantitative trait loci -- Research, Gene expression -- Analysis, Health
Published
2010

17. Genetic Analysis of the Cardiac Methylome at Single Nucleotide Resolution in a Model of Human Cardiovascular Disease

Author

Johnson, Michelle D., primary, Mueller, Michael, additional, Adamowicz-Brice, Martyna, additional, Collins, Melissa J., additional, Gellert, Pascal, additional, Maratou, Klio, additional, Srivastava, Prashant K., additional, Rotival, Maxime, additional, Butt, Shahena, additional, Game, Laurence, additional, Atanur, Santosh S., additional, Silver, Nicholas, additional, Norsworthy, Penny J., additional, Langley, Sarah R., additional, Petretto, Enrico, additional, Pravenec, Michal, additional, and Aitman, Timothy J., additional

Published
2014
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18. Characterization of management and outcomes of patients with acromegaly in Vancouver over 30 years

Author

Almalki, Mussa H, Chesover, Alexander D, Johnson, Michelle D, Wilkins, Graeme E, Maguire, John A, Ur, Ehud, Almalki, Mussa H, Chesover, Alexander D, Johnson, Michelle D, Wilkins, Graeme E, Maguire, John A, and Ur, Ehud

Abstract

Purpose: The purpose of this study was to characterize the management and outcomes of patients with acromegaly seen in single center in Vancouver, British Columbia, Canada over a 30 year period. Methods: The study involved retrospective data collection from charts of patients diagnosed with acromegaly since 1980: 130 patients (63 male and 67 female) were included in the analysis, with a mean age at diagnosis of 43 years (male) and 47 years (female). Results: The most common presenting features included acral enlargement, coarse facial features, sweating/oily skin and headache. All cases were caused by pituitary adenomas, of which 58.5% were macroadenomas and of these, 30.8% were invasive. The most common co-morbidities were hypertension 31.5%, arthralgia 28%, diabetes 27.7% and sleep apnea 23.8%. The vast majority (88.5%) of patients was treated surgically and of these patients, 21.5% also received radiotherapy and 66.9% received medical therapy. When stringent cure criteria were applied (based on latest growth hormone (GH) and IGF-1 results) the outcomes were 35.4% cured or controlled, 30% remained active, 15.4 discordant results and 19.2 % with no results reported. Twenty eight percent of patients who underwent surgery and 32% of patients who underwent radiotherapy were not cured but symptoms were moderately well controlled with medical therapy. Conclusion: Based on the size of population studied, this study showed a prevalence of acromegaly of 29 per million. The cure rate was low following surgery but with adjuvant medical treatment disease control was achieved in most individuals.

Published
2012

21. Dissection of Chromosome 18 Blood Pressure and Salt-Sensitivity Quantitative Trait Loci in the Spontaneously Hypertensive Rat

Author

Johnson, Michelle D., primary, He, Liqun, additional, Herman, Daniel, additional, Wakimoto, Hiroko, additional, Wallace, Caroline A., additional, Zidek, Vaclav, additional, Mlejnek, Petr, additional, Musilova, Alena, additional, Simakova, Miroslava, additional, Vorlicek, Jaroslav, additional, Kren, Vladimir, additional, Viklicky, Ondrej, additional, Qi, Nathan R., additional, Wang, Jiaming, additional, Seidman, Christine E., additional, Seidman, Jonathan, additional, Kurtz, Theodore W., additional, Aitman, Timothy J., additional, and Pravenec, Michal, additional

Published
2009
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23. An Economic Evaluation of Variable Housing Allowances in the Colorado Springs Military Housing Area.

Author

AIR FORCE ACADEMY CO, Weida,William J, Anselmi,Michael S, Gertcher,Franklin L, Johnson,Michelle D, AIR FORCE ACADEMY CO, Weida,William J, Anselmi,Michael S, Gertcher,Franklin L, and Johnson,Michelle D

Abstract

This study evaluates the current Department of Defense Variable Housing Allowance (VHA) Program for military families with dependents. It is exclusively for the Colorado Springs Military Housing Area (MHA), although the methodology could easily be applied to other MHA in the continental United States. For the Colorado Springs MHA, we conclude that VHA entitlements are too low for pay grades 0-1 and E-6 and below. For 0-2, 0-3, and E-7 through E-9, the current VHA entitlement are too high. We were unable to make a determination for 0-4 and above. We also explored the implications of including homeowner imputed rents in Department of Defense VHA calculations. We conclude that if imputed rents were included, VHA would be substantially lower for all pay grades. We recommend that all military members be advised on how their VHA entitlements are calculated, and how the quality of housing they choose affects their respective entitlements. We also recommend that VHA entitlements be updated quarterly between annual VHA surveys by indexing entitlements to housing cost inflation rates. (Author)

Published
1983

24. Canadian consensus guidelines for the diagnosis and management of acromegaly.

Author

Ezzat S, Serri O, Chik CL, Johnson MD, Beauregard H, Marcovitz S, Nyomba BL, Ramirez JR, and Ur E

Subjects
Acromegaly blood, Acromegaly diagnosis, Canada, Child, Diagnosis, Differential, Glucose Tolerance Test standards, Humans, Mass Screening standards, Randomized Controlled Trials as Topic, Acromegaly therapy
Abstract

Acromegaly is a chronic condition associated with considerably increased morbidity and mortality if left unchecked. In December 2004, a national meeting was held to discuss the diversity in clinical practice across the country in diagnosing and treating patients with acromegaly, as well as to seek consensus on a number of management principles. The group reviewed recent guidelines and discussed issues of diagnosis, treatment, monitoring and treating comorbidities to seek a Canadian consensus on the management of this rare disorder. Consensus was that diagnosis should include clinical and biochemical findings, but is hinged on establishing GH hypersecretion with IGF-I and OGTT testing. Treatment has traditionally included surgical resection or debulking, along with adjunctive medical therapy (primarily somatostatin analogues), if necessary, to normalize GH levels. The option of primary medical therapy in managing this condition has recently emerged and can be justified for non-surgical candidates or for those in whom surgery is not expected to be curative. Overall, improved screening practices and superior epidemiological data are required, since timely diagnosis and appropriate treatment are crucial for reducing the potentially debilitating effects of this chronic, progressive disease. The current evidence also supports the need for long-term follow-up of disease activity and comorbidities in diagnosed patients. A national meeting was held to discuss the diversity in clinical practice across the country in diagnosing and treating patients with acromegaly, as well as to seek consensus on a number of management principles. After brief reviews of the most recent Canadian guidelines and the 2004 guidelines published by the American Association of Clinical Endocrinologists, the group was asked to specifically examine the issues of diagnosis, treatment, monitoring and treating comorbidities and seek a Canadian consensus on practice. This paper summarizes the working group's findings and the points of consensus that were achieved.

Published
2006

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