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A 62-kDa Ras GTPase-activating protein (RasGAP)-associated protein is tyrosine-phosphorylated under a variety of circumstances including growth factor stimulation and in cells transformed by activated tyrosine kinases. A cDNA for p62dok, reported to be the RasGAP-associated 62-kDa protein, was recently cloned from Abl-transformed cells. In this study, the interactions of p62dokwith Bcr-Abl and associated proteins were examined. In 32D myeloid cells and Rat-1 fibroblasts transformed by p210bcr-abl, p62dokis tyrosine-phosphorylated and co-immunoprecipitates with Bcr-Abl, RasGAP, and CrkL, a Src homology 2 (SH2) and SH3 domain-containing adaptor protein. Tyrosine-phosphorylated p62dokfrom cells expressing p210bcr-ablbound directly to the SH2 domains of Abl and CrkL in a gel overlay assay. Previous work has shown that an SH2 domain deletion mutant of Bcr-Abl is defective in transforming fibroblasts but remains capable of inducing myeloid growth factor independence. In both fibroblasts and myeloid cells expressing this mutant, p62dokis underphosphorylated as compared with cells expressing full-length p210bcr-ablbut remains capable of associating with Bcr-Abl. However, in a gel overlay assay, p62dokfrom cells expressing the SH2 domain deletion was incapable of associating directly with SH2 domains of Abl and CrkL. Interestingly, no direct binding between Bcr-Abl and p62dokcould be demonstrated in a yeast two-hybrid assay. These data suggest that indirect interactions mediate the interaction between Bcr-Abl and p62dokand that the SH2 domain of Bcr-Abl is required for hyperphosphorylation of p62dok. Further, hyperphosphorylation of p62dokcorrelates with the ability of Bcr-Abl to transform fibroblasts but not with the induction of growth factor independence in myeloid cells.

The article discusses the highlights of the American Bar Association Young (ABA) Lawyers Division's (YLD) Next Steps Challenge program held at the association's 2013 Spring Conference in Minneapolis, Minnesota in May 2013. The program was created with the aim of increasing the diversity in the pipeline to the legal profession and in response to a two-year ABA Presidential Initiative that examined diversity in the legal profession.

An interview with American Bar Association (ABA) President Laurel Bellows is presented. She discusses her engagements in ABA including Chicago Bar Association's former president and active participation with the National Conference of Bar Presidents. Attorney Bellows believes that her exposure to the ABA Commission on Women in the Profession empowered her to pursue real change. She elaborates on her career path after Commission on Women including involvement in the Litigation Section.

The article profiles Omar J. Alaniz, recipient of the American Bar Association Young Lawyers Division's (ABA YLD) National Outstanding Young Lawyer of 2011. He is a senior associate at Baker Botts LLP in Dallas, Texas and specializes in the area of Chapter 11 bankruptcy reorganizations and liquidations. He earned his Doctor of Law degree from the University of Texas School of Law. Also included are information on his pro bono work, other awards and personal life.

The article presents information on the Career Development Initiative (CDI) of the American Bar Association Young Lawyers' Division (ABA YLD). The CDI programming is co-sponsored and developed with the help of the ABA Career Center. The CDI is intended to develop different aspects of a young lawyer's career.

The author offers advice to statewide affiliates of the American Bar Association (ABA) on how to keep their states' memberships active in rural areas. She suggests allowing young lawyers in rural areas to actively participate in statewide leadership to enable them to voice their opinions for realistic programming throughout the state. A discussion on how to promote awareness among young lawyers of programming from other bar organizations is given.

The article offers information on the New Lawyer Bootcamp event to be held during the American Bar Association (ABA) Midyear Meeting in Atlanta, Georgia on February 11, 2011.

The article offers information on the American Bar Association Young Lawyers Division's (ABA YLD) Spring Conference to be held in Minneapolis, Minnesota on May 16-18, 2013.

The article discusses the highlights of the Annual Meeting of the American Bar Association (ABA) held in Chicago, Illinois on August 2 to 4, 2012. During the conference, U.S. Circuit Court Judge Anne Claire Williams spoke on the importance of diversity and the impacts that people have on each other's lives. The ABA also honored the Young Lawyers Division for its efforts to help the legal needs of war veterans at the Jesse Brown Veterans Administration Medical Center.

The article offers information on mentorship programs in law school and young lawyers in the U.S. It says that mentorship program becomes unsuccessful because of lack of participation and lack of continuing participation between mentors and mentee. It mentions three approaches taken successfully in the country due to the involvement of respective affiliates including laid-back programs, group mentorship programs and one-on-one mentorship programs.

The article offers brief information on Omar J. Alaniz who become the American Bar Association Young Lawyers Division's National Outstanding Young Lawyer of 2011.

The article discusses the activities of national minority bar associations which are affiliated with the American Bar Association (ABA) Young Lawyers Division (YLD). The National Asian Pacific American Bar Association (NAPABA) held its 23rd Annual Convention in Atlanta, Georgia on November 17-20, 2011. Meanwhile, the Young Lawyers Division of the National Bar Association will hold its mid-winter meeting in St. Martin on January 18-22, 2012.

The article reports on the Affiliate Showcase (AS), a part of the May 2011 American Bar Association Young Lawyers Division Spring Conference. It says AS featured public and member service projects and initiatives from affiliated young lawyer organizations in the U.S. and abroad. It cites the Oregon New Lawyers Division's initiative that helps unemployed attorneys find legal volunteer opportunities in their areas, and the Dallas Association of Young Lawyer's Community Courts for the homeless.

The article discusses the highlights of the first New Partner and In-House Counsel Conference of the American Bar Association Young Lawyers Division (ABA YLD) which was held at the Four Seasons Hotel in Philadelphia, Pennsylvania. The welcome address was delivered by David Wolfe, chairman of ABA YLD, while Comcast Corp. General Counsel Art Block provided the keynote address. The event's closing joint session focused on the interactions and experiences of law firm partners and in-house counsel.

The article features affiliate David Veile, vice-president of the Tennessee Bar Association Young Lawyers Division and will be President-Elect in 2012 and Tennessee Young Lawyers president in 2012-2013. It presents a brief biography and career path of Veile who first worked with the Metropolitan Nashville Police Department as police officer before studying at law school, his law practice and leadership. It mentions the current law practice of Veile at Lowery, Lowery & Cherry in Lebanon, Tennessee and his focus on criminal defense and family law.

The article offers information on the Affiliate Assistance Team (AAT), how to request for assistance and ways through which affiliates can be assisted by AAT. Several ways to request for AAT assistance include contacting AAT or sending an electronic mail (e-mail) to AAT Director Kimber Gallo while help extended to affiliates include answering questions about conferences, securing funding and locating resources for conferences. It mentions the current projects of AAT including organizing the Colorado and Wyoming "Young Lawyer Leadership Roundtable."

The article announces the winners of the Outstanding Young Military Lawyer Awards given by the American Bar Association Young Lawyers Division (ABA YLD) in 2010, including Captain Stephanie Cooper, Lieutenant Christopher P. Toscano and Captain Naomi N. Porterfield.

The article features lawyer Joseph M. Hanna, 2010 recipient of the Outstanding Young Lawyer Award from the New York State Bar Association. His philanthropic efforts were highlighted through his nonprofit charity Bunkers in Baghdad, which sends golf equipment to U.S. troops in Iraq and Afghanistan. As chair and organizer of the professional networking event Success in the City, he showed his leadership and professional development skills. It cites other organizations with which Hanna is actively involved.