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1. Long-term safety and efficacy of cipaglucosidase alfa plus miglustat in individuals living with Pompe disease: an open-label phase I/II study (ATB200-02).

Author

Byrne, Barry, Schoser, Benedikt, Kishnani, Priya, Bratkovic, Drago, Clemens, Paula, Goker-Alpan, Ozlem, Ming, Xue, Roberts, Mark, Vorgerd, Matthias, Sivakumar, Kumaraswamy, van der Ploeg, Ans, Goldman, Mitchell, Wright, Jacquelyn, Holdbrook, Fred, Jain, Vipul, Benjamin, Elfrida, Johnson, Franklin, Das, Sheela, Wasfi, Yasmine, and Mozaffar, Tahseen

Subjects
n-Butyldeoxynojirimycin, Alpha glucosidases, Glycogen storage disease type II, Lysosomal storage diseases, Myozyme, Pharmacokinetics, Adult, Humans, Glycogen Storage Disease Type II, Treatment Outcome, alpha-Glucosidases, Indoles, Enzyme Replacement Therapy, Propionates, 1-Deoxynojirimycin
Abstract

Cipaglucosidase alfa plus miglustat (cipa + mig) is a novel, two-component therapy for Pompe disease. We report data from the Phase I/II ATB200-02 study for up to 48 months of treatment. Four adult cohorts, including one non-ambulatory ERT-experienced (n = 6) and three ambulatory cohorts, (two enzyme replacement therapy [ERT]-experienced cohorts [2-6 years (n = 11) and ≥ 7 years (n = 6)]), one ERT-naïve cohort (n = 6), received 20 mg/kg intravenous-infused cipa plus 260 mg oral mig biweekly. Change from baseline (CFBL) for multiple efficacy endpoints at 12, 24, 36, and 48 months, pharmacodynamics, pharmacokinetics, safety, and immunogenicity data were assessed. Six-minute walking distance (% predicted) improved at 12, 24, 36, and 48 months: pooled ambulatory ERT-experienced cohorts, mean(± standard deviation [SD]) CFBL: 6.1(± 7.84), n = 16; 5.4(± 10.56), n = 13; 3.4(± 14.66), n = 12; 5.9(± 17.36), n = 9, respectively; ERT-naïve cohort: 10.7(± 3.93), n = 6; 11.0(± 5.06), n = 6; 9.0(± 7.98), n = 5; 11.7(± 7.69), n = 4, respectively. Percent predicted forced vital capacity was generally stable in ERT-experienced cohorts, mean(± SD) CFBL - 1.2(± 5.95), n = 16; 1.0(± 7.96), n = 13; - 0.3(± 6.68), n = 10; 1.0(± 6.42), n = 6, respectively, and improved in the ERT-naïve cohort: 3.2(± 8.42), n = 6; 4.7(± 5.09), n = 6; 6.2(± 3.35), n = 5; 8.3(± 4.50), n = 4, respectively. Over 48 months, CK and Hex4 biomarkers improved in ambulatory cohorts. Overall, cipa + mig was well tolerated with a safety profile like alglucosidase alfa. ATB200-02 results show the potential benefits of cipa + mig as a long-term treatment option for Pompe disease. Trial registration number: NCT02675465 January 26, 2016.

Published
2024

3. Machine Learning and Metaheuristics can Collaborate: Image Classification Case Study

Author

Valderrama, Alvaro, Johnson, Franklin, Valle, Carlos, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Silhavy, Radek, editor, Silhavy, Petr, editor, and Prokopova, Zdenka, editor

Published
2020
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4. Duvoglustat HCl Increases Systemic and Tissue Exposure of Active Acid α-Glucosidase in Pompe Patients Co-administered with Alglucosidase α

Author

Kishnani, Priya, Tarnopolsky, Mark, Roberts, Mark, Sivakumar, Kumarswamy, Dasouki, Majed, Dimachkie, Mazen M, Finanger, Erika, Goker-Alpan, Ozlem, Guter, Karl A, Mozaffar, Tahseen, Pervaiz, Muhammad Ali, Laforet, Pascal, Levine, Todd, Adera, Matthews, Lazauskas, Richard, Sitaraman, Sheela, Khanna, Richie, Benjamin, Elfrida, Feng, Jessie, Flanagan, John J, Barth, Jay, Barlow, Carrolee, Lockhart, David J, Valenzano, Kenneth J, Boudes, Pol, Johnson, Franklin K, and Byrne, Barry

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Rare Diseases, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Liver Disease, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Development of treatments and therapeutic interventions, 1-Deoxynojirimycin, Administration, Oral, Adult, Drug Administration Schedule, Drug Synergism, Drug Therapy, Combination, Enzyme Replacement Therapy, Female, Glycogen Storage Disease Type II, Humans, Infusions, Intravenous, Lysosomes, Male, Middle Aged, Muscle, Skeletal, Patient Safety, Treatment Outcome, alpha-Glucosidases, Pompe disease, enzyme replacement therapy, pharmacokinetics, pharmacological chaperone, Biological Sciences, Technology, Medical and Health Sciences, Biotechnology, Genetics, Clinical sciences, Medical biotechnology
Abstract

Duvoglustat HCl (AT2220, 1-deoxynojirimycin) is an investigational pharmacological chaperone for the treatment of acid α-glucosidase (GAA) deficiency, which leads to the lysosomal storage disorder Pompe disease, which is characterized by progressive accumulation of lysosomal glycogen primarily in heart and skeletal muscles. The current standard of care is enzyme replacement therapy with recombinant human GAA (alglucosidase alfa [AA], Genzyme). Based on preclinical data, oral co-administration of duvoglustat HCl with AA increases exposure of active levels in plasma and skeletal muscles, leading to greater substrate reduction in muscle. This phase 2a study consisted of an open-label, fixed-treatment sequence that evaluated the effect of single oral doses of 50 mg, 100 mg, 250 mg, or 600 mg duvoglustat HCl on the pharmacokinetics and tissue levels of intravenously infused AA (20 mg/kg) in Pompe patients. AA alone resulted in increases in total GAA activity and protein in plasma compared to baseline. Following co-administration with duvoglustat HCl, total GAA activity and protein in plasma were further increased 1.2- to 2.8-fold compared to AA alone in all 25 Pompe patients; importantly, muscle GAA activity was increased for all co-administration treatments from day 3 biopsy specimens. No duvoglustat-related adverse events or drug-related tolerability issues were identified.

Published
2017

5. Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study

Author

Hughes, Derralynn A, Nicholls, Kathleen, Shankar, Suma P, Sunder-Plassmann, Gere, Koeller, David, Nedd, Khan, Vockley, Gerard, Hamazaki, Takashi, Lachmann, Robin, Ohashi, Toya, Olivotto, Iacopo, Sakai, Norio, Deegan, Patrick, Dimmock, David, Eyskens, François, Germain, Dominique P, Goker-Alpan, Ozlem, Hachulla, Eric, Jovanovic, Ana, Lourenco, Charles M, Narita, Ichiei, Thomas, Mark, Wilcox, William R, Bichet, Daniel G, Schiffmann, Raphael, Ludington, Elizabeth, Viereck, Christopher, Kirk, John, Yu, Julie, Johnson, Franklin, Boudes, Pol, Benjamin, Elfrida R, Lockhart, David J, Barlow, Carrolee, Skuban, Nina, Castelli, Jeffrey P, Barth, Jay, and Feldt-Rasmussen, Ulla

Subjects
Pediatric, Neurodegenerative, Clinical Trials and Supportive Activities, Rare Diseases, Clinical Research, Orphan Drug, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 1-Deoxynojirimycin, Administration, Oral, Adolescent, Adult, Aged, Enzyme Replacement Therapy, Fabry Disease, Female, Humans, Lysosomes, Male, Middle Aged, Molecular Chaperones, Treatment Outcome, alpha-Galactosidase, Fabry disease, Pharmacological chaperone, enzyme replacement therapy, lyso-Gb3, lysosomal storage disorder, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

BackgroundFabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, resulting in α-galactosidase (α-Gal) deficiency and accumulation of lysosomal substrates. Migalastat, an oral pharmacological chaperone being developed as an alternative to intravenous enzyme replacement therapy (ERT), stabilises specific mutant (amenable) forms of α-Gal to facilitate normal lysosomal trafficking.MethodsThe main objective of the 18-month, randomised, active-controlled ATTRACT study was to assess the effects of migalastat on renal function in patients with Fabry disease previously treated with ERT. Effects on heart, disease substrate, patient-reported outcomes (PROs) and safety were also assessed.ResultsFifty-seven adults (56% female) receiving ERT (88% had multiorgan disease) were randomised (1.5:1), based on a preliminary cell-based assay of responsiveness to migalastat, to receive 18 months open-label migalastat or remain on ERT. Four patients had non-amenable mutant forms of α-Gal based on the validated cell-based assay conducted after treatment initiation and were excluded from primary efficacy analyses only. Migalastat and ERT had similar effects on renal function. Left ventricular mass index decreased significantly with migalastat treatment (-6.6 g/m2 (-11.0 to -2.2)); there was no significant change with ERT. Predefined renal, cardiac or cerebrovascular events occurred in 29% and 44% of patients in the migalastat and ERT groups, respectively. Plasma globotriaosylsphingosine remained low and stable following the switch from ERT to migalastat. PROs were comparable between groups. Migalastat was generally safe and well tolerated.ConclusionsMigalastat offers promise as a first-in-class oral monotherapy alternative treatment to intravenous ERT for patients with Fabry disease and amenable mutations.Trial registration numberNCT00925301; Pre-results.

Published
2017

6. Long-term safety and efficacy of cipaglucosidase alfa plus miglustat in individuals living with Pompe disease:an open-label phase I/II study (ATB200-02)

Author

Byrne, Barry J., Schoser, Benedikt, Kishnani, Priya S., Bratkovic, Drago, Clemens, Paula R., Goker-Alpan, Ozlem, Ming, Xue, Roberts, Mark, Vorgerd, Matthias, Sivakumar, Kumaraswamy, van der Ploeg, Ans T., Goldman, Mitchell, Wright, Jacquelyn, Holdbrook, Fred, Jain, Vipul, Benjamin, Elfrida R., Johnson, Franklin, Das, Sheela Sitaraman, Wasfi, Yasmine, Mozaffar, Tahseen, Byrne, Barry J., Schoser, Benedikt, Kishnani, Priya S., Bratkovic, Drago, Clemens, Paula R., Goker-Alpan, Ozlem, Ming, Xue, Roberts, Mark, Vorgerd, Matthias, Sivakumar, Kumaraswamy, van der Ploeg, Ans T., Goldman, Mitchell, Wright, Jacquelyn, Holdbrook, Fred, Jain, Vipul, Benjamin, Elfrida R., Johnson, Franklin, Das, Sheela Sitaraman, Wasfi, Yasmine, and Mozaffar, Tahseen

Abstract

Cipaglucosidase alfa plus miglustat (cipa + mig) is a novel, two-component therapy for Pompe disease. We report data from the Phase I/II ATB200-02 study for up to 48 months of treatment. Four adult cohorts, including one non-ambulatory ERT-experienced (n = 6) and three ambulatory cohorts, (two enzyme replacement therapy [ERT]-experienced cohorts [2–6 years (n = 11) and ≥ 7 years (n = 6)]), one ERT-naïve cohort (n = 6), received 20 mg/kg intravenous-infused cipa plus 260 mg oral mig biweekly. Change from baseline (CFBL) for multiple efficacy endpoints at 12, 24, 36, and 48 months, pharmacodynamics, pharmacokinetics, safety, and immunogenicity data were assessed. Six-minute walking distance (% predicted) improved at 12, 24, 36, and 48 months: pooled ambulatory ERT-experienced cohorts, mean(± standard deviation [SD]) CFBL: 6.1(± 7.84), n = 16; 5.4(± 10.56), n = 13; 3.4(± 14.66), n = 12; 5.9(± 17.36), n = 9, respectively; ERT-naïve cohort: 10.7(± 3.93), n = 6; 11.0(± 5.06), n = 6; 9.0(± 7.98), n = 5; 11.7(± 7.69), n = 4, respectively. Percent predicted forced vital capacity was generally stable in ERT-experienced cohorts, mean(± SD) CFBL − 1.2(± 5.95), n = 16; 1.0(± 7.96), n = 13; − 0.3(± 6.68), n = 10; 1.0(± 6.42), n = 6, respectively, and improved in the ERT-naïve cohort: 3.2(± 8.42), n = 6; 4.7(± 5.09), n = 6; 6.2(± 3.35), n = 5; 8.3(± 4.50), n = 4, respectively. Over 48 months, CK and Hex4 biomarkers improved in ambulatory cohorts. Overall, cipa + mig was well tolerated with a safety profile like alglucosidase alfa. ATB200-02 results show the potential benefits of cipa + mig as a long-term treatment option for Pompe disease. Trial registration number: NCT02675465 January 26, 2016.

Published
2024

7. Long-term safety and efficacy of cipaglucosidase alfa plus miglustat in individuals living with Pompe disease: an open-label phase I/II study (ATB200-02)

Author

Byrne, Barry J., primary, Schoser, Benedikt, additional, Kishnani, Priya S., additional, Bratkovic, Drago, additional, Clemens, Paula R., additional, Goker-Alpan, Ozlem, additional, Ming, Xue, additional, Roberts, Mark, additional, Vorgerd, Matthias, additional, Sivakumar, Kumaraswamy, additional, van der Ploeg, Ans T., additional, Goldman, Mitchell, additional, Wright, Jacquelyn, additional, Holdbrook, Fred, additional, Jain, Vipul, additional, Benjamin, Elfrida R., additional, Johnson, Franklin, additional, Das, Sheela Sitaraman, additional, Wasfi, Yasmine, additional, and Mozaffar, Tahseen, additional

Published
2023
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8. B-PSA: A Binary Pendulum Search Algorithm for the Feature Selection Problem

Author

Crawford, Broderick, primary, Cisternas-Caneo, Felipe, additional, Sepúlveda, Katherine, additional, Soto, Ricardo, additional, Paz, Álex, additional, Peña, Alvaro, additional, León de la Barra, Claudio, additional, Rodriguez-Tello, Eduardo, additional, Astorga, Gino, additional, Castro, Carlos, additional, Johnson, Franklin, additional, and Giachetti, Giovanni, additional

Published
2023
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9. Oral Migalastat HCl Leads to Greater Systemic Exposure and Tissue Levels of Active α-Galactosidase A in Fabry Patients when Co-Administered with Infused Agalsidase

Author

Warnock, David G, Bichet, Daniel G, Holida, Myrl, Goker-Alpan, Ozlem, Nicholls, Kathy, Thomas, Mark, Eyskens, Francois, Shankar, Suma, Adera, Mathews, Sitaraman, Sheela, Khanna, Richie, Flanagan, John J, Wustman, Brandon A, Barth, Jay, Barlow, Carrolee, Valenzano, Kenneth J, Lockhart, David J, Boudes, Pol, and Johnson, Franklin K

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Trials and Supportive Activities, Clinical Research, Neurosciences, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, 1-Deoxynojirimycin, Administration, Oral, Adult, Area Under Curve, Demography, Fabry Disease, Humans, Infusion Pumps, Isoenzymes, Male, Middle Aged, Recombinant Proteins, Skin, alpha-Galactosidase, General Science & Technology
Abstract

UnlabelledMigalastat HCl (AT1001, 1-Deoxygalactonojirimycin) is an investigational pharmacological chaperone for the treatment of α-galactosidase A (α-Gal A) deficiency, which leads to Fabry disease, an X-linked, lysosomal storage disorder. The currently approved, biologics-based therapy for Fabry disease is enzyme replacement therapy (ERT) with either agalsidase alfa (Replagal) or agalsidase beta (Fabrazyme). Based on preclinical data, migalastat HCl in combination with agalsidase is expected to result in the pharmacokinetic (PK) enhancement of agalsidase in plasma by increasing the systemic exposure of active agalsidase, thereby leading to increased cellular levels in disease-relevant tissues. This Phase 2a study design consisted of an open-label, fixed-treatment sequence that evaluated the effects of single oral doses of 150 mg or 450 mg migalastat HCl on the PK and tissue levels of intravenously infused agalsidase (0.2, 0.5, or 1.0 mg/kg) in male Fabry patients. As expected, intravenous administration of agalsidase alone resulted in increased α-Gal A activity in plasma, skin, and peripheral blood mononuclear cells (PBMCs) compared to baseline. Following co-administration of migalastat HCl and agalsidase, α-Gal A activity in plasma was further significantly increased 1.2- to 5.1-fold compared to agalsidase administration alone, in 22 of 23 patients (95.6%). Importantly, similar increases in skin and PBMC α-Gal A activity were seen following co-administration of migalastat HCl and agalsidase. The effects were not related to the administered migalastat HCl dose, as the 150 mg dose of migalastat HCl increased α-Gal A activity to the same extent as the 450 mg dose. Conversely, agalsidase had no effect on the plasma PK of migalastat. No migalastat HCl-related adverse events or drug-related tolerability issues were identified.Trial registrationClinicalTrials.gov NCT01196871.

Published
2015

10. A Framework to Simplify Usability Analysis of Constraint Solvers

Author

Crawford, Broderick, Soto, Ricardo, Johnson, Franklin, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, and Meiselwitz, Gabriele, editor

Published
2018
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14. The Fundamentals Volume 2

Author

Anderson, Robert, Moule, Handley Carr Glyn, Wright, George Frederick, Kyle, Melvin Grove, Johnson, Franklin, and Mauro, Philip

Subjects
The Fundamentals, vol. 2 (Nonfiction work), Literature/writing
Abstract

LibriVox recording of The Fundamentals Volume 2 by Sir Robert Anderson; Handley Carr Glyn Moule; George Frederick Wright; Melvin Grove Kyle; Franklin Johnson; Philip Mauro. Read in English by LibriVox [...]

Published
2021

15. Firefly Algorithm to Solve a Project Scheduling Problem

Author

Crawford, Broderick, Soto, Ricardo, Johnson, Franklin, Valencia, Carlos, Paredes, Fernando, Kacprzyk, Janusz, Series editor, Silhavy, Radek, editor, Senkerik, Roman, editor, Oplatkova, Zuzana Kominkova, editor, Silhavy, Petr, editor, and Prokopova, Zdenka, editor

Published
2016
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16. Solving Manufacturing Cell Design Problems Using a Shuffled Frog Leaping Algorithm

Author

Soto, Ricardo, Crawford, Broderick, Vega, Emanuel, Johnson, Franklin, Paredes, Fernando, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio, Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Gaber, Tarek, editor, Hassanien, Aboul Ella, editor, El-Bendary, Nashwa, editor, and Dey, Nilanjan, editor

Published
2016
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17. A XOR-Based ABC Algorithm for Solving Set Covering Problems

Author

Soto, Ricardo, Crawford, Broderick, Lizama, Sebastián, Johnson, Franklin, Paredes, Fernando, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio, Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Gaber, Tarek, editor, Hassanien, Aboul Ella, editor, El-Bendary, Nashwa, editor, and Dey, Nilanjan, editor

Published
2016
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18. A Software Project Management Problem Solved by Firefly Algorithm

Author

Crawford, Broderick, Soto, Ricardo, Johnson, Franklin, Misra, Sanjay, Olguín, Eduardo, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Rocha, Ana Maria A.C., editor, Torre, Carmelo M., editor, Taniar, David, editor, Apduhan, Bernady O., editor, Stankova, Elena, editor, and Wang, Shangguang, editor

Published
2016
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32. A Scheduling Problem for Software Project Solved with ABC Metaheuristic

Author

Crawford, Broderick, Soto, Ricardo, Johnson, Franklin, Vargas, Melissa, Misra, Sanjay, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Gavrilova, Marina L., editor, Rocha, Ana Maria Alves Coutinho, editor, Torre, Carmelo, editor, Taniar, David, editor, and Apduhan, Bernady O., editor

Published
2015
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33. A Comparison of Three Recent Nature-Inspired Metaheuristics for the Set Covering Problem

Author

Crawford, Broderick, Soto, Ricardo, Peña, Cristian, Riquelme-Leiva, Marco, Torres-Rojas, Claudio, Misra, Sanjay, Johnson, Franklin, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Gavrilova, Marina L., editor, Rocha, Ana Maria Alves Coutinho, editor, Torre, Carmelo, editor, Taniar, David, editor, and Apduhan, Bernady O., editor

Published
2015
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34. A Binary Fruit Fly Optimization Algorithm to Solve the Set Covering Problem

Author

Crawford, Broderick, Soto, Ricardo, Torres-Rojas, Claudio, Peña, Cristian, Riquelme-Leiva, Marco, Misra, Sanjay, Johnson, Franklin, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Gavrilova, Marina L., editor, Rocha, Ana Maria Alves Coutinho, editor, Torre, Carmelo, editor, Taniar, David, editor, and Apduhan, Bernady O., editor

Published
2015
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35. A Teaching-Learning-Based Optimization Algorithm for Solving Set Covering Problems

Author

Crawford, Broderick, Soto, Ricardo, Aballay, Felipe, Misra, Sanjay, Johnson, Franklin, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Gavrilova, Marina L., editor, Rocha, Ana Maria Alves Coutinho, editor, Torre, Carmelo, editor, Taniar, David, editor, and Apduhan, Bernady O., editor

Published
2015
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36. Autonomous Tuning for Constraint Programming via Artificial Bee Colony Optimization

Author

Soto, Ricardo, Crawford, Broderick, Mella, Felipe, Flores, Javier, Galleguillos, Cristian, Misra, Sanjay, Johnson, Franklin, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Gavrilova, Marina L., editor, Rocha, Ana Maria Alves Coutinho, editor, Torre, Carmelo, editor, Taniar, David, editor, and Apduhan, Bernady O., editor

Published
2015
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37. Automated, Adaptive, and Optimized Search for CSPs via Cuckoo Search

Author

Soto, Ricardo, Crawford, Broderick, Flores, Javier, Mella, Felipe, Galleguillos, Cristian, Johnson, Franklin, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Tan, Ying, editor, Shi, Yuhui, editor, Buarque, Fernando, editor, Gelbukh, Alexander, editor, Das, Swagatam, editor, and Engelbrecht, Andries, editor

Published
2015
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38. Solving the Set Covering Problem with Binary Cat Swarm Optimization

Author

Crawford, Broderick, Soto, Ricardo, Berríos, Natalia, Johnson, Franklin, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Tan, Ying, editor, Shi, Yuhui, editor, Buarque, Fernando, editor, Gelbukh, Alexander, editor, Das, Swagatam, editor, and Engelbrecht, Andries, editor

Published
2015
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39. Online Control of Enumeration Strategies via Bat-Inspired Optimization

Author

Soto, Ricardo, Crawford, Broderick, Olivares, Rodrigo, Johnson, Franklin, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Ferrández Vicente, José Manuel, editor, Álvarez-Sánchez, José Ramón, editor, de la Paz López, Félix, editor, Toledo-Moreo, Fco. Javier, editor, and Adeli, Hojjat, editor

Published
2015
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40. A Binary Cuckoo Search Algorithm for Solving the Set Covering Problem

Author

Soto, Ricardo, Crawford, Broderick, Olivares, Rodrigo, Barraza, Jorge, Johnson, Franklin, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Ferrández Vicente, José Manuel, editor, Álvarez-Sánchez, José Ramón, editor, de la Paz López, Félix, editor, Toledo-Moreo, Fco. Javier, editor, and Adeli, Hojjat, editor

Published
2015
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44. Self-adaptive Systems: Facilitating the Use of Combinatorial Problem Solvers

Author

Crawford, Broderick, Soto, Ricardo, Monfroy, Eric, Johnson, Franklin, Junqueira Barbosa, Simone Diniz, editor, Chen, Phoebe, editor, Cuzzocrea, Alfredo, editor, Du, Xiaoyong, editor, Filipe, Joaquim, editor, Kara, Orhun, editor, Kotenko, Igor, editor, Sivalingam, Krishna M., editor, Ślęzak, Dominik, editor, Washio, Takashi, editor, Yang, Xiaokang, editor, and Stephanidis, Constantine, editor

Published
2014
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45. A Better Understanding of the Behaviour of Metaheuristics: A Psychological View

Author

Crawford, Broderick, Soto, Ricardo, de la Barra, Claudio León, Crawford, Kathleen, Paredes, Fernando, Johnson, Franklin, Junqueira Barbosa, Simone Diniz, editor, Chen, Phoebe, editor, Cuzzocrea, Alfredo, editor, Du, Xiaoyong, editor, Filipe, Joaquim, editor, Kara, Orhun, editor, Kotenko, Igor, editor, Sivalingam, Krishna M., editor, Ślęzak, Dominik, editor, Washio, Takashi, editor, Yang, Xiaokang, editor, and Stephanidis, Constantine, editor

Published
2014
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47. A 2-level Approach for the Set Covering Problem: Parameter Tuning of Artificial Bee Colony Algorithm by Using Genetic Algorithm

Author

Crawford, Broderick, Soto, Ricardo, Palma, Wenceslao, Johnson, Franklin, Paredes, Fernando, Olguín, Eduardo, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Tan, Ying, editor, Shi, Yuhui, editor, and Coello, Carlos A. Coello, editor

Published
2014
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48. The Use of Metaheuristics to Software Project Scheduling Problem

Author

Crawford, Broderick, Soto, Ricardo, Johnson, Franklin, Misra, Sanjay, Paredes, Fernando, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Rocha, Ana Maria A. C., editor, Torre, Carmelo, editor, Rocha, Jorge Gustavo, editor, Falcão, Maria Irene, editor, Taniar, David, editor, Apduhan, Bernady O., editor, and Gervasi, Osvaldo, editor

Published
2014
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