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1. Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy

Author

McCauley, Kathryn E, Rackaityte, Elze, LaMere, Brandon, Fadrosh, Douglas W, Fujimura, Kei E, Panzer, Ariane R, Lin, Din L, Lynch, Kole V, Halkias, Joanna, Mendoza, Ventura F, Burt, Trevor D, Bendixsen, Casper, Barnes, Kathrine, Kim, Haejin, Jones, Kyra, Ownby, Dennis R, Johnson, Christine C, Seroogy, Christine M, Gern, James E, Boushey, Homer A, Lynch, Susan V, and Workgroup, for the ECHO Children’s Respiratory and Environmental

Subjects
Biomedical and Clinical Sciences, Asthma, Prevention, Pediatric, Lung, Clinical Research, Aetiology, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, Inflammatory and immune system, Respiratory, Good Health and Well Being, Animals, Bacteria, Female, Gastrointestinal Microbiome, Humans, Hypersensitivity, Immediate, Immune Tolerance, Immunoglobulin E, Infant, Mice, Pregnancy, ECHO Children’s Respiratory and Environmental Workgroup, Lactobacillus, asthma, atopy, immune tolerance, inherited bacteria, microbiota, prenatal, transmission, vaginal, vaginal microbiota, Biomedical and clinical sciences
Abstract

Maternal asthma status, prenatal exposures, and infant gut microbiota perturbation are associated with heightened risk of atopy and asthma risk in childhood, observations hypothetically linked by intergenerational microbial transmission. Using maternal vaginal (n = 184) and paired infant stool (n = 172) samples, we identify four compositionally and functionally distinct Lactobacillus-dominated vaginal microbiota clusters (VCs) that relate to prenatal maternal health and exposures and infant serum immunoglobulin E (IgE) status at 1 year. Variance in bacteria shared between mother and infant pairs relate to VCs, maternal allergy/asthma status, and infant IgE levels. Heritable bacterial gene pathways associated with infant IgE include fatty acid synthesis and histamine and tryptophan degradation. In vitro, vertically transmitted Lactobacillus jensenii strains induce immunosuppressive phenotypes on human antigen-presenting cells. Murine supplementation with L. jensenii reduces lung eosinophils, neutrophilic expansion, and the proportion of interleukin-4 (IL-4)+ CD4+ T cells. Thus, bacterial and atopy heritability are intimately linked, suggesting a microbial component of intergenerational disease transmission.

Published
2022

2. Regional and sociodemographic differences in average BMI among US children in the ECHO program

Author

Bekelman, Traci A, Dabelea, Dana, Ganiban, Jody M, Law, Andrew, Reilly, Alexandra McGovern, Althoff, Keri N, Mueller, Noel, Camargo, Carlos A, Duarte, Cristiane S, Dunlop, Anne L, Elliott, Amy J, Ferrara, Assiamira, Gold, Diane R, Hertz‐Picciotto, Irva, Hartert, Tina, Hipwell, Alison E, Huddleston, Kathi, Johnson, Christine C, Karagas, Margaret R, Karr, Catherine J, Hershey, Gurjit K Khurana, Leve, Leslie, Mahabir, Somdat, McEvoy, Cindy T, Neiderhiser, Jenae, Oken, Emily, Rundle, Andrew, Sathyanarayana, Sheela, Turley, Christine, Tylavsky, Frances A, Watson, Sara E, Wright, Rosalind, Zhang, Mingyu, Zoratti, Edward, and Outcomes, program collaborators for Environmental influences on Child Health

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, Pediatric, Clinical Research, Prevention, Body Mass Index, Child, Ethnicity, Female, Hispanic or Latino, Humans, Male, Prospective Studies, program collaborators for Environmental influences on Child Health Outcomes, Endocrinology & Metabolism
Abstract

ObjectiveThe aim of this study was to describe the association of individual-level characteristics (sex, race/ethnicity, birth weight, maternal education) with child BMI within each US Census region and variation in child BMI by region.MethodsThis study used pooled data from 25 prospective cohort studies. Region of residence (Northeast, Midwest, South, West) was based on residential zip codes. Age- and sex-specific BMI z scores were the outcome.ResultsThe final sample included 14,313 children with 85,428 BMI measurements, 49% female and 51% non-Hispanic White. Males had a lower average BMI z score compared with females in the Midwest (β = -0.12, 95% CI: -0.19 to -0.05) and West (β = -0.12, 95% CI: -0.20 to -0.04). Compared with non-Hispanic White children, BMI z score was generally higher among children who were Hispanic and Black but not across all regions. Compared with the Northeast, average BMI z score was significantly higher in the Midwest (β = 0.09, 95% CI: 0.05 to 0.14) and lower in the South (β = -0.12, 95% CI: -0.16 to -0.08) and West (β = -0.14, 95% CI: -0.19 to -0.09) after adjustment for age, sex, race/ethnicity, and birth weight.ConclusionsRegion of residence was associated with child BMI z scores, even after adjustment for sociodemographic characteristics. Understanding regional influences can inform targeted efforts to mitigate BMI-related disparities among children.

Published
2021

4. The Milk Metabolome of Non-secretor and Lewis Negative Mothers

Author

Wang, Aidong, Koleva, Petya, du Toit, Elloise, Geddes, Donna T, Munblit, Daniel, Prescott, Susan L, Eggesbø, Merete, Johnson, Christine C, Wegienka, Ganesa, Shimojo, Naoki, Campbell, Dianne, Kozyrskyj, Anita L, and Slupsky, Carolyn M

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Clinical Research, Nutrition, Pediatric, human milk, metabolome, Lewis negative, oligosaccharide, energy metabolism, South Africa, non-secretor, Agricultural Biotechnology, Nutrition and Dietetics, Nutrition and dietetics
Abstract

Introduction: The functional role of milk for the developing neonate is an area of great interest, and a significant amount of research has been done. However, a lot of work remains to fully understand the complexities of milk, and the variations imposed through genetics. It has previously been shown that both secretor (Se) and Lewis blood type (Le) status impacts the human milk oligosaccharide (HMO) content of human milk. While some studies have compared the non-HMO milk metabolome of Se+ and Se- women, none have reported on the non-HMO milk metabolome of Se- and Le- mothers. Method and Results: To determine the differences in the non-HMO milk metabolome between Se-Le- mothers and other HMO phenotypes (Se+Le+, Se+Le-, and Se-Le+), 10 milk samples from 10 lactating mothers were analyzed using nuclear magnetic resonance (NMR) spectroscopy. Se or Le HMO phenotypes were assigned based on the presence and absence of 6 HMOs generated by the Se and Le genes. After classification, 58 milk metabolites were compared among the HMO phenotypes. Principal component analysis (PCA) identified clear separation between Se-Le- milk and the other milks. Fold change analysis demonstrated that the Se-Le- milk had major differences in free fatty acids, free amino acids, and metabolites related to energy metabolism. Conclusion: The results of this brief research report suggest that the milk metabolome of mothers with the Se-Le- phenotype differs in its non-HMO metabolite composition from mothers with other HMO phenotypes.

Published
2021

5. Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

Author

Smith, P.B., Newby, K.L., Jacobson, L.P., Catellier, D.J., Gershon, R., Cella, D., Alshawabkeh, A., Aschner, J., Merhar, S., Ren, C., Reynolds, A., Keller, R., Pryhuber, G., Duncan, A., Lampland, A., Wadhawan, R., Wagner, C., Hudak, M., Mayock, D., Walshburn, L., Teitelbaum, S.L., Stroustrup, A., Trasande, L., Blair, C., Gatzke-Kopp, L., Swingler, M., Mansbach, J., Spergel, J., Puls, H., Stevenson, M., Bauer, C., Deoni, S., Duarte, C., Dunlop, A., Elliott, A., Croen, L., Bacharier, L., O’Connor, G., Kattan, M., Wood, R., Hershey, G., Ownby, D., Hertz-Picciotto, I., Hipwell, A., Karagas, M., Karr, C., Mason, A., Sathyanarayana, S., Lester, B., Carter, B., Neal, C., Smith, L., Helderman, J., Leve, L., Ganiban, J., Neiderhiser, J., Weiss, S., Zeiger, R., Tepper, R., Lyall, K., Landa, R., Ozonoff, S., Schmidt, R., Dager, S., Schultz, R., Piven, J., Volk, H., Vaidya, R., Obeid, R., Rollins, C., Bear, K., Pastyrnak, S., Lenski, M., Msall, M., Frazier, J., Washburn, L., Montgomery, A., Barone, C., McKane, P., Paneth, N., Elliott, M., Herbstman, J., Schantz, S., Porucznik, C., Silver, R., Conradt, E., Bosquet-Enlow, M., Huddleston, K., Bush, N., Nguyen, R., O'Connor, T., Samuels-Kalow, M., Miller, Rachel L., Schuh, Holly, Chandran, Aruna, Aris, Izzuddin M., Bendixsen, Casper, Blossom, Jeffrey, Breton, Carrie, Camargo, Carlos A., Jr., Canino, Glorisa, Carroll, Kecia N., Commodore, Sarah, Cordero, José F., Dabelea, Dana M., Ferrara, Assiamira, Fry, Rebecca C., Ganiban, Jody M., Gern, James E., Gilliland, Frank D., Gold, Diane R., Habre, Rima, Hare, Marion E., Harte, Robyn N., Hartert, Tina, Hasegawa, Kohei, Khurana Hershey, Gurjit K., Jackson, Daniel J., Joseph, Christine, Kerver, Jean M., Kim, Haejin, Litonjua, Augusto A., Marsit, Carmen J., McEvoy, Cindy, Mendonça, Eneida A., Moore, Paul E., Nkoy, Flory L., O’Connor, Thomas G., Oken, Emily, Ownby, Dennis, Perzanowski, Matthew, Rivera-Spoljaric, Katherine, Ryan, Patrick H., Singh, Anne Marie, Stanford, Joseph B., Wright, Rosalind J., Wright, Robert O., Zanobetti, Antonella, Zoratti, Edward, and Johnson, Christine C.

Published
2023
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7. The Milk Metabolome of Non-secretor and Lewis Negative Mothers.

Author

Wang, Aidong, Koleva, Petya, du Toit, Elloise, Geddes, Donna T, Munblit, Daniel, Prescott, Susan L, Eggesbø, Merete, Johnson, Christine C, Wegienka, Ganesa, Shimojo, Naoki, Campbell, Dianne, Kozyrskyj, Anita L, and Slupsky, Carolyn M

Subjects
Lewis negative, South Africa, energy metabolism, human milk, metabolome, non-secretor, oligosaccharide, Agricultural Biotechnology, Nutrition and Dietetics
Abstract

Introduction: The functional role of milk for the developing neonate is an area of great interest, and a significant amount of research has been done. However, a lot of work remains to fully understand the complexities of milk, and the variations imposed through genetics. It has previously been shown that both secretor (Se) and Lewis blood type (Le) status impacts the human milk oligosaccharide (HMO) content of human milk. While some studies have compared the non-HMO milk metabolome of Se+ and Se- women, none have reported on the non-HMO milk metabolome of Se- and Le- mothers. Method and Results: To determine the differences in the non-HMO milk metabolome between Se-Le- mothers and other HMO phenotypes (Se+Le+, Se+Le-, and Se-Le+), 10 milk samples from 10 lactating mothers were analyzed using nuclear magnetic resonance (NMR) spectroscopy. Se or Le HMO phenotypes were assigned based on the presence and absence of 6 HMOs generated by the Se and Le genes. After classification, 58 milk metabolites were compared among the HMO phenotypes. Principal component analysis (PCA) identified clear separation between Se-Le- milk and the other milks. Fold change analysis demonstrated that the Se-Le- milk had major differences in free fatty acids, free amino acids, and metabolites related to energy metabolism. Conclusion: The results of this brief research report suggest that the milk metabolome of mothers with the Se-Le- phenotype differs in its non-HMO metabolite composition from mothers with other HMO phenotypes.

Published
2020

8. Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance

Author

Levan, Sophia R, Stamnes, Kelsey A, Lin, Din L, Panzer, Ariane R, Fukui, Elle, McCauley, Kathryn, Fujimura, Kei E, McKean, Michelle, Ownby, Dennis R, Zoratti, Edward M, Boushey, Homer A, Cabana, Michael D, Johnson, Christine C, and Lynch, Susan V

Subjects
Microbiology, Biological Sciences, Pediatric, Asthma, Lung, Genetics, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Respiratory, Animals, Bacteria, Bacterial Physiological Phenomena, Bacterial Proteins, Disease Models, Animal, Epoxide Hydrolases, Feces, Female, Gastrointestinal Microbiome, Humans, Immune Tolerance, Infant, Newborn, Linoleic Acids, Male, Mice, T-Lymphocytes, Regulatory, Medical Microbiology
Abstract

Neonates at risk of childhood atopy and asthma exhibit perturbation of the gut microbiome, metabolic dysfunction and increased concentrations of 12,13-diHOME in their faeces. However, the mechanism, source and contribution of this lipid to allergic inflammation remain unknown. Here, we show that intra-abdominal treatment of mice with 12,13-diHOME increased pulmonary inflammation and decreased the number of regulatory T (Treg) cells in the lungs. Treatment of human dendritic cells with 12,13-diHOME altered expression of PPARγ-regulated genes and reduced anti-inflammatory cytokine secretion and the number of Treg cells in vitro. Shotgun metagenomic sequencing of neonatal faeces indicated that bacterial epoxide hydrolase (EH) genes are more abundant in the gut microbiome of neonates who develop atopy and/or asthma during childhood. Three of these bacterial EH genes (3EH) specifically produce 12,13-diHOME, and treatment of mice with bacterial strains expressing 3EH caused a decrease in the number of lung Treg cells in an allergen challenge model. In two small birth cohorts, an increase in the copy number of 3EH or the concentration of 12,13-diHOME in the faeces of neonates was found to be associated with an increased probability of developing atopy, eczema or asthma during childhood. Our data indicate that elevated 12,13-diHOME concentrations impede immune tolerance and may be produced by bacterial EHs in the neonatal gut, offering a mechanistic link between perturbation of the gut microbiome during early life and atopy and asthma during childhood.

Published
2019

9. Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods

Author

Fulkerson, Patricia C, primary, Lussier, Stephanie J, additional, Bendixsen, Casper G, additional, Castina, Sharon M, additional, Gebretsadik, Tebeb, additional, Marlin, Jessica S, additional, Russell, Patty B, additional, Seibold, Max A, additional, Everman, Jamie L, additional, Moore, Camille M, additional, Snyder, Brittney M, additional, Thompson, Kathy, additional, Tregoning, George S, additional, Wellford, Stephanie, additional, Arbes, Samuel J, additional, Bacharier, Leonard B, additional, Calatroni, Agustin, additional, Camargo Jr, Carlos A, additional, Dupont, William D, additional, Furuta, Glenn T, additional, Gruchalla, Rebecca S, additional, Gupta, Ruchi S, additional, Hershey, Gurjit Khurana, additional, Jackson, Daniel J, additional, Johnson, Christine C, additional, Kattan, Meyer, additional, Liu, Andrew H, additional, Murrison, Liza, additional, O’Connor, George T, additional, Phipatanakul, Wanda, additional, Rivera-Spoljaric, Katherine, additional, Rothenberg, Marc E, additional, Seroogy, Christine M, additional, Teach, Stephen J, additional, Zoratti, Edward M, additional, Togias, Alkis, additional, Hartert, Tina V, additional, and HEROS study team, on behalf of the, additional

Published
2024
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10. Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study

Author

Achten, Niek, Ainsworth, John, Akkerman, Nonna, Anderson, Elizabeth, Anderson, Larry J., Andrews, Howard, Armagost, Elizabeth, Aubuchon, Mary Ann, Bach, Julia, Bacharier, Leonard, Barnes, Kathrine L., Barone, Charles, Bauer, Irma, Beamer, Paloma, Becker, Patrice, Bednarek, Alyssa, Bellemore, Stacey, Bendixsen, Casper G., Biagini Myers, Jocelyn M., Billheimer, Dean, Billstrand, Christine, Birg, Geraldine, Blocki, Shirley, Bloomberg, Gordon, Bobbitt, Kevin, Bochkov, Yury, Bourgeois, Karen, Boushey, Homer, Brockman-Schneider, Rebecca, Brunwasser, Steven M., Budrevich, Richard, Burkle, Jeffrey W., Busse, William, Calatroni, Agustin, Campbell, Janice, Carlson-Dakes, Kirsten, Cassidy-Bushrow, Andrea, Chappell, James D., Chasman, Deborah, Chipps, Teresa M., Chirkova, Tatiana, Cole, Deanna, Connolly, Alexandra, Cootauco, Michelle, Costello, Kaitlin, Couch, Philip, Coull, Brent, Craven, Mark, Crisafi, Gina, Cruikshank, William, Curtsinger, Kristi, Custovic, Adnan, Das, Suman R., DaSilva, Douglas, Datta, Soma, Davidson, Brent, De La Ossa, Lydia, DeVries, Mark, Di, Qian, Dixon, Samara, Donnerbauer, Erin, Dorst, Marian, Doyle, Susan, Dresen, Amy, Dupont, William D., Durrange, Janet, Erickson, Heidi, Evans, Michael D., Ezell, Jerel, Farnham, Leanna, Filardo-Collins, Roxanne, Finazzo, Salvatore, Flege, Zachary, Fleurat, Conner, Floerke, Heather, Floerke, Dorothy, Foss, Terry, Freie, Angela, Frome, Wayne, Fye, Samantha, Gagalis, Lisa, Gammell, Rebecca, Gangnon, Ronald E., Ge, James E., Gebretsadik, Tebeb, Gergen, Peter, Gern, James E., Gibson, Heike, Gjerasi, Edlira, Gold, Diane R., Gonzalez, Nicole, Goodman, Kayla, Gress, Lisa, Grindle, Kristine, Groeschen, Taylor, Hallmark, Brian, Halonen, Marilyn, Hart, Jaime, Hartert, Tina V., Havstad, Suzanne, Heinritz, Patrick, Hensley Alford, Sharon, Herbstman, Julie, Hernandez, Kellie, Hoepner, Lori, Jackson, Daniel J., Jadhao, Samadhan J., Jaffee, Katy, James, Peter, Jezioro, Jacqueline, Jimenez Pescador, Marcia, Johnson, Christine C., Johnson, Tara, Johnson, Camille, Jones, Amelia, Jones, Kyra, Jones, Paul, Jordan, Carolina, Joseph, Christine LM, Kattan, Meyer, Keidel, Kristina, Keifer, Matthew C., Kelley, Rick, Khurana Hershey, Gurgit K., Kim, Haejin, Kloog, Itai, Koepel, Tammy Kronenwetter, Koerkenmeier, Clint, Ladick, Laura, Lamm, Carin, Larkin, Emma, Lederman, Howard, Lee-Parritz, Aviva, Leimenstoll, Stephanie, Lemanske, Jr., Robert F., LeMasters, Grace K., Levin, Albert M., Levine, Jessica, Liu, Xinhua, Liu, Zhouwen, Lopez, Silvia, Lothrop, Nathan, Lovinsky-Desir, Stephanie, Lukacs, Nicholas, Lynch, Susan, Lynch, Christian, Mann, Erik, Martin, Jennifer, Martin, Lisa, Martinez, Fernando D., Matsui, Elizabeth, McCauley, Katherine, Mccollum, Megan, McCullough, Judith, McKennon, Chris G., Meece, Jennifer, Mendonca, Eneida, Mikus, Lance, Miller, Rachel L., Minton, Patricia, Mitchell, Herman, Moon, Vicki, Moore, Paul E., Morgan, Wayne, Morgan, Valerie, Morgan, David, Murrison, Liza, Nicholas, Charlotte, Nicolae, Daniel, Nunez, Adam, O'Connor, George, O'Toole, Sharon, Ober, Carole, Olson, Brent F., Ong, Irene, Osmundson, Sarah, Ownby, Dennis, Pappas, Tressa, Perera, Frederica, Perzanowski, Matthew, Peterson, Edward, Pierce, Marcela, Price-Johnson, Penny, Rajamanickam, Victoria, Ramirez, Judyth, Ray, Kimberly, Renneberg, Megan, Requia, Weeberb, Riley, Kylie, Rivera, Janelle, Rivers, Neisha, Roberg, Kathy, Rogers, Theresa, Rosas-Salazar, Christian, Russell, Pat, Ryan, Patrick H., Sadovsky, Yoel, Salazar, Lisa, Sampson, Hugh, Sandel, Megan, Schoettler, Nathan, Schwartz, Joel, Scott, Dena, Seroogy, Christine M., Sharp, Renee, Shilts, Meghan H., Sigelman, Steve, Singh, Anne Marie, Sitarik, Alexandra, Smartt, Ernestine, Sorkness, Ronald, Sorkness, Christine, Spangenberg, Amber, Sperling, Rhoda, Spies, David, Stern, Debra A., Stoffel, Brandy, Peebles, R. Stokes, Stouffer, Gina, Strauchman Boyer, Cathey, Suddeuth, Caitlin, Tachinardi, Umberto, Tang, Deliang, Tang, Zhengzheng, Tate, Jena, Taylor, William, Tensing, Krista, Tesson, Elizabeth, Thompson, Kathy, Thompson, Emma, Tisler, Christopher, Togias, Alkis, Turi, Kedir, Turner, Victoria, Tuzova, Marina, VanWormer, Jeffrey J., Visness, Cynthia M., Vrtis, Rose, Wahlman, Anthony, Wang, Lena, Wegienka, Ganesa, Wells, Karen, Wentworth-Sheilds, William, Wheatley, Lisa, Whitney, Nitsa, Williams, L. Keoki, Witter, Frank, Wolfe, Christopher, Wood, Robert A., Woodcroft, Kimberley, Woodward, Kim B., Wright, Anne L., Wright, Rosalind, Wu, Pingsheng, Yaeger, Melissa, Yaniv, Perri, Zanobetti, Antonella, Zhang, Shirley, Zook, Patricia, Zoratti, Edward M., McKennan, Chris G, Magnaye, Kevin M, Altman, Matthew C, Washington, Charles, 3rd, Stanhope, Catherine, Naughton, Katherine A, Rosasco, Mario G, Bacharier, Leonard B, Gold, Diane R, Hartert, Tina, Khurana Hershey, Gurjit K, Hogarth, D Kyle, Jackson, Daniel J, Johnson, Christine C, Lemanske, Robert F, Lynch, Susan V, Mendonca, Eneida A, Miller, Rachel L, Naureckas, Edward T, O'Connor, George T, Seroogy, Christine M, White, Steven R, Wood, Robert A, Wright, Anne L, Zoratti, Edward M, Martinez, Fernando D, Nicolae, Dan L, Levin, Albert M, and Gern, James E

Published
2020
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11. African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans

Author

Washington, III, Charles, Dapas, Matthew, Biddanda, Arjun, Magnaye, Kevin M., Aneas, Ivy, Helling, Britney A., Szczesny, Brooke, Boorgula, Meher Preethi, Taub, Margaret A., Kenny, Eimear, Mathias, Rasika A., Barnes, Kathleen C., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gereige, Jessica D., Makhija, Melanie, Gruchalla, Rebecca S., Gill, Michelle A., Liu, Andrew H., Rastogi, Deepa, Busse, William, Gergen, Peter J., Visness, Cynthia M., Gold, Diane R., Hartert, Tina, Johnson, Christine C., Lemanske, Jr., Robert F., Martinez, Fernando D., Miller, Rachel L., Ownby, Dennis, Seroogy, Christine M., Wright, Anne L., Zoratti, Edward M., Bacharier, Leonard B., Kattan, Meyer, O’Connor, George T., Wood, Robert A., Nobrega, Marcelo A., Altman, Matthew C., Jackson, Daniel J., Gern, James E., McKennan, Christopher G., and Ober, Carole

Published
2022
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12. Worldwide Variation in Human Milk Metabolome: Indicators of Breast Physiology and Maternal Lifestyle?

Author

Gay, Melvin CL, Koleva, Petya T, Slupsky, Carolyn M, Toit, Elloise du, Eggesbo, Merete, Johnson, Christine C, Wegienka, Ganesa, Shimojo, Naoki, Campbell, Dianne E, Prescott, Susan L, Munblit, Daniel, Geddes, Donna T, Kozyrskyj, Anita L, and InVIVO LactoActive Study Investigators

Subjects
InVIVO LactoActive Study Investigators, Breast, Milk, Human, Humans, Hypersensitivity, Choline, Carbohydrates, Amino Acids, Milk Proteins, Magnetic Resonance Spectroscopy, Mothers, Life Style, Energy Metabolism, Continental Population Groups, Ethnic Groups, United States, Japan, Australia, Norway, Female, Male, Metabolome, human milk, lactation, milk metabolites, milk metabolomics, Milk, Human, Food Sciences, Nutrition and Dietetics
Abstract

Human milk provides essential substrates for the optimal growth and development of a breastfed infant. Besides providing nutrients to the infant, human milk also contains metabolites which form an intricate system between maternal lifestyle, such as the mother's diet and the gut microbiome, and infant outcomes. This study investigates the variation of these human milk metabolites from five different countries. Human milk samples (n = 109) were collected one month postpartum from Australia, Japan, the USA, Norway, and South Africa and were analyzed by nuclear magnetic resonance. The partial least squares discriminant analysis (PLS-DA) showed separation between either maternal countries of origin or ethnicities. Variation between countries in concentration of metabolites, such as 2-oxoglutarate, creatine, and glutamine, in human milk, between countries, could provide insights into problems, such as mastitis and/or impaired functions of the mammary glands. Several important markers of milk production, such as lactose, betaine, creatine, glutamate, and glutamine, showed good correlation between each metabolite. This work highlights the importance of milk metabolites with respect to maternal lifestyle and the environment, and also provides the framework for future breastfeeding and microbiome studies in a global context.

Published
2018

13. Pediatric asthma incidence rates in the United States from 1980 to 2017

Author

Johnson, Christine C., Havstad, Suzanne L., Ownby, Dennis R., Joseph, Christine L.M., Sitarik, Alexandra R., Biagini Myers, Jocelyn, Gebretsadik, Tebeb, Hartert, Tina V., Khurana Hershey, Gurjit K., Jackson, Daniel J., Lemanske, Robert F., Jr., Martin, Lisa J., Zoratti, Edward M., Visness, Cynthia M., Ryan, Patrick H., Gold, Diane R., Martinez, Fernando D., Miller, Rachel L., Seroogy, Christine M., Wright, Anne L., and Gern, James E.

Published
2021
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16. Precocious infant fecal microbiome promotes enterocyte barrier dysfuction, altered neuroendocrine signaling and associates with increased childhood obesity risk

Author

Yong, Germaine J. M., primary, Porsche, Cara E., additional, Sitarik, Alexandra R., additional, Fujimura, Kei E., additional, McCauley, Kathryn, additional, Nguyen, Dat T., additional, Levin, Albert M., additional, Woodcroft, Kimberley J., additional, Ownby, Dennis R., additional, Rundle, Andrew G., additional, Johnson, Christine C., additional, Cassidy-Bushrow, Andrea, additional, and Lynch, Susan V., additional

Published
2023
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18. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children

Author

Lynch, Susan V, Wood, Robert A, Boushey, Homer, Bacharier, Leonard B, Bloomberg, Gordon R, Kattan, Meyer, O’Connor, George T, Sandel, Megan T, Calatroni, Agustin, Matsui, Elizabeth, Johnson, Christine C, Lynn, Henry, Visness, Cynthia M, Jaffee, Katy F, Gergen, Peter J, Gold, Diane R, Wright, Rosalind J, Fujimura, Kei, Rauch, Marcus, Busse, William W, and Gern, James E

Subjects
Asthma, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Prevention, Pediatric, Lung, Aetiology, 2.2 Factors relating to the physical environment, Inflammatory and immune system, Respiratory, Sustainable Cities and Communities, Allergens, Antigens, Bacterial, Bacteria, Case-Control Studies, Child, Preschool, Cohort Studies, Dust, Environmental Exposure, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Recurrence, Respiratory Sounds, Risk, United States, Urban Population, atopy, allergen exposure, microbial exposure, inner city, Immunology, Allergy
Abstract

BackgroundWheezing illnesses cause major morbidity in infants and are frequent precursors to asthma.ObjectiveWe sought to examine environmental factors associated with recurrent wheezing in inner-city environments.MethodsThe Urban Environment and Childhood Asthma study examined a birth cohort at high risk for asthma (n = 560) in Baltimore, Boston, New York, and St Louis. Environmental assessments included allergen exposure and, in a nested case-control study of 104 children, the bacterial content of house dust collected in the first year of life. Associations were determined among environmental factors, aeroallergen sensitization, and recurrent wheezing at age 3 years.ResultsCumulative allergen exposure over the first 3 years was associated with allergic sensitization, and sensitization at age 3 years was related to recurrent wheeze. In contrast, first-year exposure to cockroach, mouse, and cat allergens was negatively associated with recurrent wheeze (odds ratio, 0.60, 0.65, and 0.75, respectively; P ≤ .01). Differences in house dust bacterial content in the first year, especially reduced exposure to specific Firmicutes and Bacteriodetes, was associated with atopy and atopic wheeze. Exposure to high levels of both allergens and this subset of bacteria in the first year of life was most common among children without atopy or wheeze.ConclusionsIn inner-city environments children with the highest exposure to specific allergens and bacteria during their first year were least likely to have recurrent wheeze and allergic sensitization. These findings suggest that concomitant exposure to high levels of certain allergens and bacteria in early life might be beneficial and suggest new preventive strategies for wheezing and allergic diseases.

Published
2014

21. House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection

Author

Fujimura, Kei E, Demoor, Tine, Rauch, Marcus, Faruqi, Ali A, Jang, Sihyug, Johnson, Christine C, Boushey, Homer A, Zoratti, Edward, Ownby, Dennis, Lukacs, Nicholas W, and Lynch, Susan V

Subjects
Lung, Prevention, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Inflammatory and immune system, Animals, Bronchial Hyperreactivity, Dogs, Dust, Environmental Exposure, Flow Cytometry, Fluorescence, Gastrointestinal Tract, Lactobacillus, Mice, Mice, Inbred BALB C, Microbiota, Ovalbumin, Respiratory Syncytial Virus Infections, Reverse Transcriptase Polymerase Chain Reaction, Th2 Cells, house environment, airway adaptive immunity, gastrointestinal bacterial community, Lactobacilliaceae
Abstract

Exposure to dogs in early infancy has been shown to reduce the risk of childhood allergic disease development, and dog ownership is associated with a distinct house dust microbial exposure. Here, we demonstrate, using murine models, that exposure of mice to dog-associated house dust protects against ovalbumin or cockroach allergen-mediated airway pathology. Protected animals exhibited significant reduction in the total number of airway T cells, down-regulation of Th2-related airway responses, as well as mucin secretion. Following dog-associated dust exposure, the cecal microbiome of protected animals was extensively restructured with significant enrichment of, amongst others, Lactobacillus johnsonii. Supplementation of wild-type animals with L. johnsonii protected them against both airway allergen challenge or infection with respiratory syncytial virus. L. johnsonii-mediated protection was associated with significant reductions in the total number and proportion of activated CD11c(+)/CD11b(+) and CD11c(+)/CD8(+) cells, as well as significantly reduced airway Th2 cytokine expression. Our results reveal that exposure to dog-associated household dust results in protection against airway allergen challenge and a distinct gastrointestinal microbiome composition. Moreover, the study identifies L. johnsonii as a pivotal species within the gastrointestinal tract capable of influencing adaptive immunity at remote mucosal surfaces in a manner that is protective against a variety of respiratory insults.

Published
2014

22. Impact of Timing of Targeted Muscle Reinnervation on Pain and Opioid Intake Following Major Limb Amputation.

Author

Reid, Risa T., Johnson, Christine C., Gaston, R. Glenn, and Loeffler, Bryan J.

Abstract

Background: Targeted muscle reinnervation (TMR) has been shown to play an important role in managing neuromas. However, the impact of the timing of TMR on pain visual analogue scale (VAS) scores or patient opioid use has not been thoroughly explored. We hypothesized that TMR performed acutely would lead to lower VAS scores and decreased opioid intake. Methods: Prospectively collected data from an amputation registry at a single institution were utilized to identify patients who underwent TMR. Acute TMR was defined as TMR performed within 1 month of the major limb amputation. Primary outcomes included VAS pain scores and patient-reported opioid consumption. Results: In all, 25 patients (26 limbs) were identified in the acute group, and 18 patients (18 limbs) were identified in the delayed group. At intermediate follow-up (between 4 and 8 months postoperatively) and at final follow-up, the average pain VAS score in the delayed TMR group was significantly higher than that in the acute group (5.2 vs. 1.9 at intermediate P =.01 and 6.2 vs. 1.9 at final P =.002). In all, 84% of the amputees overall were not consuming opioid medications at the time of final follow-up (79% acute, 88% delayed, P =.72). There were no statistically significant differences in opioid consumption between the acute and delayed group at intermediate follow-up (P =.35) or at final follow-up (P =.68). Conclusions: TMR is an effective procedure to reduce pain following major limb amputation. Patients with TMR performed acutely had significantly lower VAS pain scores at both intermediate and final follow-up than patients with TMR performed in a delayed setting. Type of Study/Level of Evidence: Therapeutic II. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Maternal Pre-Pregnancy BMI, Breastfeeding, and Child BMI.

Author

Shipp, Gayle M., Wosu, Adaeze C., Knapp, Emily A., Sauder, Katherine A., Dabelea, Dana, Wei Perng, Yeyi Zhu, Ferrara, Assiamira, Dunlop, Anne L., Deoni, Sean, Gern, James, Porucznik, Christy, Aris, Izzuddin M., Karagas, Margaret R., Sathyanarayana, Sheela, O'Connor, Tom G., Carroll, Kecia N., Wright, Rosalind J., Hockett, Christine W., and Johnson, Christine C.

Published
2024
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25. Performance of the Pediatric Asthma Risk Score across Diverse Populations

Author

Biagini, Jocelyn M., primary, Martin, Lisa J., additional, He, Hua, additional, Bacharier, Leonard B., additional, Gebretsadik, Tebeb, additional, Hartert, Tina V., additional, Jackson, Daniel J., additional, Kim, Haejin, additional, Miller, Rachel L., additional, Rivera-Spoljaric, Katherine, additional, Schauberger, Eric M., additional, Singh, Anne Marie, additional, Visness, Cynthia M., additional, Wegienka, Ganesa, additional, Ownby, Dennis R., additional, Gold, Diane R., additional, Martinez, Fernando D., additional, Johnson, Christine C., additional, Wright, Anne L., additional, Gern, James E., additional, and Khurana Hershey, Gurjit K., additional

Published
2023
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26. Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program

Author

Yeh, Hsueh-Han, primary, Peltz-Rauchman, Cathryn, additional, Johnson, Christine C., additional, Pawloski, Pamala A., additional, Chesla, David, additional, Waring, Stephen C., additional, Stevens, Alan B., additional, Epstein, Mara, additional, Joseph, Christine, additional, Miller-Matero, Lisa R., additional, Gui, Hongsheng, additional, Tang, Amy, additional, Boerwinkle, Eric, additional, Cicek, Mine, additional, Clark, Cheryl R., additional, Cohn, Elizabeth, additional, Gebo, Kelly, additional, Loperena, Roxana, additional, Mayo, Kelsey, additional, Mockrin, Stephen, additional, Ohno-Machado, Lucila, additional, Schully, Sheri, additional, Ramirez, Andrea H., additional, Qian, Jun, additional, and Ahmedani, Brian K., additional

Published
2023
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27. Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program

Author

Miller, Rachel L., primary, Schuh, Holly, additional, Chandran, Aruna, additional, Aris, Izzuddin M., additional, Bendixsen, Casper, additional, Blossom, Jeffrey, additional, Breton, Carrie, additional, Camargo, Carlos A., additional, Canino, Glorisa, additional, Carroll, Kecia N., additional, Commodore, Sarah, additional, Cordero, José F., additional, Dabelea, Dana M., additional, Ferrara, Assiamira, additional, Fry, Rebecca C., additional, Ganiban, Jody M., additional, Gern, James E., additional, Gilliland, Frank D., additional, Gold, Diane R., additional, Habre, Rima, additional, Hare, Marion E., additional, Harte, Robyn N., additional, Hartert, Tina, additional, Hasegawa, Kohei, additional, Khurana Hershey, Gurjit K., additional, Jackson, Daniel J., additional, Joseph, Christine, additional, Kerver, Jean M., additional, Kim, Haejin, additional, Litonjua, Augusto A., additional, Marsit, Carmen J., additional, McEvoy, Cindy, additional, Mendonça, Eneida A., additional, Moore, Paul E., additional, Nkoy, Flory L., additional, O’Connor, Thomas G., additional, Oken, Emily, additional, Ownby, Dennis, additional, Perzanowski, Matthew, additional, Rivera-Spoljaric, Katherine, additional, Ryan, Patrick H., additional, Singh, Anne Marie, additional, Stanford, Joseph B., additional, Wright, Rosalind J., additional, Wright, Robert O., additional, Zanobetti, Antonella, additional, Zoratti, Edward, additional, Johnson, Christine C., additional, Smith, P.B., additional, Newby, K.L., additional, Jacobson, L.P., additional, Catellier, D.J., additional, Gershon, R., additional, Cella, D., additional, Alshawabkeh, A., additional, Aschner, J., additional, Merhar, S., additional, Ren, C., additional, Reynolds, A., additional, Keller, R., additional, Pryhuber, G., additional, Duncan, A., additional, Lampland, A., additional, Wadhawan, R., additional, Wagner, C., additional, Hudak, M., additional, Mayock, D., additional, Walshburn, L., additional, Teitelbaum, S.L., additional, Stroustrup, A., additional, Trasande, L., additional, Blair, C., additional, Gatzke-Kopp, L., additional, Swingler, M., additional, Mansbach, J., additional, Spergel, J., additional, Puls, H., additional, Stevenson, M., additional, Bauer, C., additional, Deoni, S., additional, Duarte, C., additional, Dunlop, A., additional, Elliott, A., additional, Croen, L., additional, Bacharier, L., additional, O’Connor, G., additional, Kattan, M., additional, Wood, R., additional, Hershey, G., additional, Ownby, D., additional, Hertz-Picciotto, I., additional, Hipwell, A., additional, Karagas, M., additional, Karr, C., additional, Mason, A., additional, Sathyanarayana, S., additional, Lester, B., additional, Carter, B., additional, Neal, C., additional, Smith, L., additional, Helderman, J., additional, Leve, L., additional, Ganiban, J., additional, Neiderhiser, J., additional, Weiss, S., additional, Zeiger, R., additional, Tepper, R., additional, Lyall, K., additional, Landa, R., additional, Ozonoff, S., additional, Schmidt, R., additional, Dager, S., additional, Schultz, R., additional, Piven, J., additional, Volk, H., additional, Vaidya, R., additional, Obeid, R., additional, Rollins, C., additional, Bear, K., additional, Pastyrnak, S., additional, Lenski, M., additional, Msall, M., additional, Frazier, J., additional, Washburn, L., additional, Montgomery, A., additional, Barone, C., additional, McKane, P., additional, Paneth, N., additional, Elliott, M., additional, Herbstman, J., additional, Schantz, S., additional, Porucznik, C., additional, Silver, R., additional, Conradt, E., additional, Bosquet-Enlow, M., additional, Huddleston, K., additional, Bush, N., additional, Nguyen, R., additional, O'Connor, T., additional, and Samuels-Kalow, M., additional

Published
2023
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28. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children

Author

Altman, Matthew C., Gill, Michelle A., Whalen, Elizabeth, Babineau, Denise C., Shao, Baomei, Liu, Andrew H., Jepson, Brett, Gruchalla, Rebecca S., O’Connor, George T., Pongracic, Jacqueline A., Kercsmar, Carolyn M., Khurana Hershey, Gurjit K., Zoratti, Edward M., Johnson, Christine C., Teach, Stephen J., Kattan, Meyer, Bacharier, Leonard B., Beigelman, Avraham, Sigelman, Steve M., Presnell, Scott, Gern, James E., Gergen, Peter J., Wheatley, Lisa M., Togias, Alkis, Busse, William W., and Jackson, Daniel J.

Published
2019
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29. Development of a standardized approach for environmental microbiota investigations related to asthma development in children

Author

Fujimura, Kei E, Rauch, Marcus, Matsui, Elizabeth, Iwai, Shoko, Calatroni, Agustin, Lynn, Henry, Mitchell, Herman, Johnson, Christine C, Gern, James E, Togias, Alkis, Boushey, Homer A, Kennedy, Suzanne, and Lynch, Susan V

Subjects
Microbiology, Biological Sciences, Lung, Genetics, Human Genome, Pediatric, Clinical Research, Asthma, Biota, Child, Dust, Environmental Microbiology, Humans, Metagenome, Metagenomics, Microarray Analysis, Phylogeny, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Dust microbiome, Standardized sampling, Phylogenetic microarray, 454-Pyrosequencing, Medical Microbiology
Abstract

Standardized studies examining environmental microbial exposure in populations at risk for asthma are necessary to improve our understanding of the role this factor plays in disease development. Here we describe studies aimed at developing guidelines for high-resolution culture-independent microbiome profiling, using a phylogenetic microarray (PhyloChip), of house dust samples in a cohort collected as part of the NIH-funded Inner City Asthma Consortium (ICAC). We demonstrate that though extracted DNA concentrations varied across dust samples, the majority produced sufficient 16S rRNA to be profiled by the array. Comparison of array and 454-pyrosequencing performed in parallel on a subset of samples, illustrated that increasingly deeper sequencing efforts validated greater numbers of array-detected taxa. Community composition agreement across samples exhibited a hierarchy in concordance, with the highest level of agreement in replicate array profiles followed by samples collected from adjacent 1×1 m(2) sites in the same room, adjacent sites with different sized sampling quadrants (1×1 and 2×2 m(2)), different sites within homes (living and bedroom) to lowest in living room samples collected from different homes. The guidelines for sample collection and processing in this pilot study extend beyond PhyloChip based studies of house-associated microbiota, and bear relevance for other microbiome profiling approaches such as next-generation sequencing.

Published
2012

35. Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents

Author

Pongracic, Jacqueline A., Krouse, Rebecca Z., Babineau, Denise C., Zoratti, Edward M., Cohen, Robyn T., Wood, Robert A., Khurana Hershey, Gurjit K., Kercsmar, Carolyn M., Gruchalla, Rebecca S., Kattan, Meyer, Teach, Stephen J., Johnson, Christine C., Bacharier, Leonard B., Gern, James E., Sigelman, Steven M., Gergen, Peter J., Togias, Alkis, Visness, Cynthia M., Busse, William W., and Liu, Andrew H.

Published
2016
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36. The impact of prenatal dog keeping on infant gut microbiota development

Author

Panzer, Ariane R., primary, Sitarik, Alexandra R., additional, Fadrosh, Doug, additional, Havstad, Suzanne L., additional, Jones, Kyra, additional, Davidson, Brent, additional, Finazzo, Salvatore, additional, Wegienka, Ganesa R., additional, Woodcroft, Kimberley, additional, Lukacs, Nicholas W., additional, Levin, Albert M., additional, Ownby, Dennis R., additional, Johnson, Christine C., additional, Lynch, Susan V., additional, and Zoratti, Edward M., additional

Published
2023
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37. Abstract A058: Treatment fragmentation and timely treatment in racially and socioeconomically diverse patients with head and neck cancers

Author

Tam, Samantha M.D., primary, Su, Wan-Ting K., additional, Cannella, Cara E., additional, Tang, Amy, additional, Latack, Katie A., additional, Elssis, Farah, additional, Ali, Haythem, additional, Chang, Steven S., additional, Popoff, Andrew M., additional, Neslund-Dudas, Christine, additional, Ahmedani, Brian, additional, and Johnson, Christine C., additional

Published
2023
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39. The Children’s Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population

Author

Gern, James E., Jackson, Daniel J., Lemanske, Jr, Robert F., Seroogy, Christine M., Tachinardi, Umberto, Craven, Mark, Hwang, Stephen Y., Hamilton, Carol M., Huggins, Wayne, O’Connor, George T., Gold, Diane R., Miller, Rachel, Kattan, Meyer, Johnson, Christine C., Ownby, Dennis, Zoratti, Edward M., Wood, Robert A., Visness, Cynthia M., Martinez, Fernando, Wright, Anne, Lynch, Susan, Ober, Carole, Khurana Hershey, Gurjit K., Ryan, Patrick, Hartert, Tina, and Bacharier, Leonard B.

Published
2019
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42. When a birth cohort grows up: challenges and opportunities in longitudinal developmental origins of health and disease (DOHaD) research

Author

Oken, Emily, primary, Bastain, Theresa M., additional, Bornkamp, Nicole, additional, Breton, Carrie V., additional, Fry, Rebecca C., additional, Gold, Diane R., additional, Hivert, Marie-France, additional, Howland, Steve, additional, Jackson, Daniel J., additional, Johnson, Christine C., additional, Jones, Kyra, additional, Killingbeck, MollyAn, additional, O’Shea, T. Michael, additional, Ortega, Marleny, additional, Ownby, Dennis, additional, Perera, Frederica, additional, Rollins, Julie V., additional, and Herbstman, Julie B., additional

Published
2022
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44. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation

Author

Fujimura, Kei E, Sitarik, Alexandra R, Havstad, Suzanne, Lin, Din L, Levan, Sophia, Fadrosh, Douglas, Panzer, Ariane R, LaMere, Brandon, Rackaityte, Elze, Lukacs, Nicholas W, Wegienka, Ganesa, Boushey, Homer A, Ownby, Dennis R, Zoratti, Edward M, Levin, Albert M, Johnson, Christine C, and Lynch, Susan V

Subjects
Childhood asthma -- Research, Microbiota (Symbiotic organisms) -- Research, Cell differentiation -- Research, Biological sciences, Health
Abstract

Author(s): Kei E Fujimura [1]; Alexandra R Sitarik [2]; Suzanne Havstad [2]; Din L Lin [1]; Sophia Levan [1]; Douglas Fadrosh [1]; Ariane R Panzer [1]; Brandon LaMere [1]; Elze [...]

Published
2016
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46. Risk factors for SARS-CoV-2 infection and transmission in households with children with asthma and allergy: A prospective surveillance study

Author

Seibold, Max A., primary, Moore, Camille M., additional, Everman, Jamie L., additional, Williams, Blake J.M., additional, Nolin, James D., additional, Fairbanks-Mahnke, Ana, additional, Plender, Elizabeth G., additional, Patel, Bhavika B., additional, Arbes, Samuel J., additional, Bacharier, Leonard B., additional, Bendixsen, Casper G., additional, Calatroni, Agustin, additional, Camargo, Carlos A., additional, Dupont, William D., additional, Furuta, Glenn T., additional, Gebretsadik, Tebeb, additional, Gruchalla, Rebecca S., additional, Gupta, Ruchi S., additional, Khurana Hershey, Gurjit K., additional, Murrison, Liza Bronner, additional, Jackson, Daniel J., additional, Johnson, Christine C., additional, Kattan, Meyer, additional, Liu, Andrew H., additional, Lussier, Stephanie J., additional, O’Connor, George T., additional, Rivera-Spoljaric, Katherine, additional, Phipatanakul, Wanda, additional, Rothenberg, Marc E., additional, Seroogy, Christine M., additional, Teach, Stephen J., additional, Zoratti, Edward M., additional, Togias, Alkis, additional, Fulkerson, Patricia C., additional, and Hartert, Tina V., additional

Published
2022
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48. Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods

Author

Fulkerson, Patricia, primary, Lussier, Stephanie, additional, Bendixsen, Casper, additional, Castina, Sharon, additional, Gebretsadik, Tebeb, additional, Marlin, Jessica, additional, Russell, Patty, additional, Seibold, Max, additional, Everman, Jamie, additional, Moore, Camille, additional, Snyder, Britney, additional, Thompson, Kathy, additional, Tregoning, George, additional, Wellford, Stephanie, additional, Arbes, Samuel, additional, Bacharier, Leonard, additional, Calatroni, Augustin, additional, Camrgo, Carlos, additional, Dupont, William, additional, Furuta, Glenn, additional, Gruchalla, Rebecca, additional, Gupta, Ruchi, additional, Hershey, Gurjit Khurana, additional, Jackson, Daniel J, additional, Johnson, Christine C, additional, Kattan, Meyer, additional, Liu, Andrew H, additional, Murrison, Liza, additional, O'Connor, George T, additional, Phipatanakul, Wanda, additional, Rivera-Spoljaric, Katherine, additional, Rothenberg, Marc E, additional, Seroogy, Christine, additional, Teach, Stephen, additional, Zoratti, Edward, additional, Togias, Alkis, additional, and Hartert, Tina, additional

Published
2022
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49. Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations

Author

McCauley, Kathryn E., primary, Flynn, Kaitlin, additional, Calatroni, Agustin, additional, DiMassa, Vincent, additional, LaMere, Brandon, additional, Fadrosh, Douglas W., additional, Lynch, Kole V., additional, Gill, Michelle A., additional, Pongracic, Jacqueline A., additional, Khurana Hershey, Gurjit K., additional, Kercsmar, Carolyn M., additional, Liu, Andrew H., additional, Johnson, Christine C., additional, Kim, Haejin, additional, Kattan, Meyer, additional, O’Connor, George T., additional, Bacharier, Leonard B., additional, Teach, Stephen J., additional, Gergen, Peter J., additional, Wheatley, Lisa M., additional, Togias, Alkis, additional, LeBeau, Petra, additional, Presnell, Scott, additional, Boushey, Homer A., additional, Busse, William W., additional, Gern, James E., additional, Jackson, Daniel J., additional, Altman, Matthew C., additional, and Lynch, Susan V., additional

Published
2022
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50. Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop

Author

Bousquet, Jean, Gern, James E., Martinez, Fernando D., Anto, Josep M., Johnson, Christine C., Holt, Patrick G., Lemanske, Robert F., Jr., Le Souëf, Peter N., Tepper, Robert S., von Mutius, Erika R.M., Arshad, S. Hasan, Bacharier, Leonard B., Becker, Allan, Belanger, Kathleen, Bergström, Anna, Bernstein, David I., Cabana, Michael D., Carroll, Kecia N., Castro, Mario, Cooper, Philip J., Gillman, Matthew W., Gold, Diane R., Henderson, John, Heinrich, Joachim, Hong, Soo-Jong, Jackson, Daniel J., Keil, Thomas, Kozyrskyj, Anita L., Lødrup Carlsen, Karin C., Miller, Rachel L., Momas, Isabelle, Morgan, Wayne J., Noel, Patricia, Ownby, Dennis R., Pinart, Mariona, Ryan, Patrick H., Schwaninger, Julie M., Sears, Malcolm R., Simpson, Angela, Smit, Henriette A., Stern, Debra A., Subbarao, Padmaja, Valenta, Rudolf, Wang, Xiaobin, Weiss, Scott T., Wood, Robert, Wright, Anne L., Wright, Rosalind J., Togias, Alkis, and Gergen, Peter J.

Published
2014
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