114 results on '"John R. Griffin"'
Search Results
2. Cellular dermatofibroma: A hyperkeratotic indurated plaque on the thigh
- Author
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Amira Elbendary, John R Griffin, Dirk M Elston, and Shyam B Verma
- Subjects
Dermatology ,RL1-803 - Published
- 2016
- Full Text
- View/download PDF
3. Asymptomatic erythematous plaque
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Olga V Udovenko, John R Griffin, and Dirk M Elston
- Subjects
Dermatology ,RL1-803 - Published
- 2015
- Full Text
- View/download PDF
4. 'Dark Paget' Cells in Extramammary Paget Disease: A Staining Artifact and Diagnostic Pitfall
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John R. Griffin, Abdul H. Diwan, Sarah K. Galfione, and Mugahed Hamza
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Artifact (error) ,Pathology ,medicine.medical_specialty ,business.industry ,Paget Disease ,medicine ,Dermatology ,General Medicine ,business ,Pathology and Forensic Medicine ,Staining - Published
- 2020
5. Initial skin cancer screening for solid organ transplant recipients in the United States: Delphi method development of expert consensus guidelines
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Allison Hanlon, Timothy Patton, Christina L. Chung, Selim M. Arcasoy, Jenny Hu, Gavin Hickey, Rade Tomic, David G. Brodland, Garrett R. Roll, Nicolae Leca, Daniel F. Dilling, Jorge M. Mallea, Sarah T. Arron, Don Hayes, Sarah A. Myers, Norah A. Terrault, Daniel Berg, Mark Wigger, Alice L. Gray, Sofya Tokman, Lauren D. Crow, David A. Baran, Faramarz H. Samie, Matthew C. Fox, Erika D. Lease, Marcy Neuburg, James C. Lee, Bryan T. Carroll, Anokhi Jambusaria-Pahlajani, Robert Samuel Hopkins, A. Emtiazjoo, Milan J. Anadkat, William Black, Rajiv I. Nijhawan, John A. Carucci, Karthik Ranganna, Melissa Bleicher, John R. Griffin, Seaver L. Soon, Amanda R. Twigg, Jonathan E. Holtz, Alan Menter, Rehana L. Ahmed, Christie P. Thomas, Ramsey R. Hachem, Travis W. Blalock, Elizabeth M. Billingsley, Justin J. Leitenberger, Amit D. Parulekar, Teresa Soriano, George Chaux, Conway C. Huang, Shang I Brian Jiang, Vishal A. Patel, Jennifer A. Stein, Mark Abdelmalek, Clark C. Otley, So Yeon Paek, Timothy W. Chang, Manisha J. Patel, Ashwin K. Ravichandran, Jonathan P. Singer, Siddhartha G. Kapnadak, Alden M. Doyle, Shahid M. Malik, Shelley A. Hall, Kristin Bibee, Mariah Brown, Simin Goral, Daniel C. Brennan, Pooja Singh, Edward S. Kraus, Nathalie C. Zeitouni, Carrie Ann Cusack, Maria Isabel Longo, Douglas J. Norman, Rachel Redenius, Stefan E. Lowenstein, Ronald A. Squires, Sandra J. Taler, Thomas Stasko, Nkanyezi H. Ferguson, Mary Ann Lim, Thuzar M. Shin, Melissa Pugliano-Mauro, and Scott W. Fosko
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African american ,Transplantation ,medicine.medical_specialty ,Skin cancer screening ,integumentary system ,business.industry ,Delphi method ,Expert consensus ,030230 surgery ,medicine.disease ,Malignancy ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,030211 gastroenterology & hepatology ,Transplant patient ,Skin cancer ,business ,Intensive care medicine ,Solid organ transplantation - Abstract
Skin cancer is the most common malignancy affecting solid organ transplant recipients (SOTR), and SOTR experience increased skin cancer-associated morbidity and mortality. There are no formal multidisciplinary guidelines for skin cancer screening after transplant, and current practices are widely variable. We conducted three rounds of Delphi method surveys with a panel of 84 U.S. dermatologists and transplant physicians to establish skin cancer screening recommendations for SOTR. The transplant team should risk stratify SOTR for screening, and dermatologists should perform skin cancer screening by full-body skin examination. SOTR with a history of skin cancer should continue regular follow-up with dermatology for skin cancer surveillance. High-risk transplant patients include thoracic organ recipients, SOTR age 50 and above, and male SOTR. High-risk Caucasian patients should be screened within 2 years after transplant, all Caucasian, Asian, Hispanic, and high-risk African American patients should be screened within 5 years after transplant. No consensus was reached regarding screening for low-risk African American SOTR. We propose a standardized approach to skin cancer screening in SOTR based on multidisciplinary expert consensus. These guidelines prioritize and emphasize the need for screening for SOTR at greatest risk for skin cancer.
- Published
- 2019
6. Defining the role of mirtazapine in the treatment of refractory pruritus
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John R. Griffin, Bahir H. Chamseddin, and Bilal Fawaz
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medicine.medical_specialty ,Comorbid insomnia ,Mirtazapine ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Refractory ,Internal medicine ,mental disorders ,medicine ,Humans ,In patient ,Receptors, Histamine H1 ,030203 arthritis & rheumatology ,Clinical Trials as Topic ,business.industry ,Pruritus ,medicine.disease ,Antidepressive Agents ,Analgesics, Opioid ,Receptors, Serotonin ,Anxiety ,Major depressive disorder ,Anti depressant ,medicine.symptom ,business ,medicine.drug - Abstract
Mirtazapine has traditionally been used for the treatment of major depressive disorder, with an added benefit in patients who have comorbid insomnia or anxiety. Recent studies describe its usefulness in treating refractory pruritus of various causes as well. Our goal is to better define the use of mirtazapine in the treatment of refractory pruritus.Through a thorough literature review of PubMed, we identified all reports of the use of mirtazapine for pruritus.Upon examination of 8 supporting articles, we found mirtazapine has quality evidence for the treatment of intra-thecal morphine-induced pruritus. Mirtazapine may also be effective in treating pruritus related to various other conditions, including psoriasis, atopic dermatitis, cutaneous malignancies (primary or metastatic), hematologic malignancies (lymphomas and leukemias), liver failure, renal failure, cholestasis, as well as pruritus of unknown origin.Mirtazapine plays a role in treatment for intra-thecel morphine-induced pruritis yet high-quality trials are needed to confirm its efficacy in other dermatologic conditions.
- Published
- 2019
7. A solitary auricular polyp
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Michael J McFall, John R Griffin, and Dirk M Elston
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Dermatology ,RL1-803 - Published
- 2015
- Full Text
- View/download PDF
8. Surgical site identification with personal digital device: A prospective pilot study
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Anisha B. Patel, Ana M. Ciurea, Tri H. Nguyen, Adam M. Parsons, Michael R. Migden, John R. Griffin, Christopher Chan, Leon Chen, and Alexander B. Aria
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Adult ,Male ,medicine.medical_specialty ,Biopsy ,Pilot Projects ,Documentation ,Dermatology ,Skin Diseases ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Biopsy Site ,Photography ,Humans ,Medicine ,Medical physics ,Prospective Studies ,skin and connective tissue diseases ,Aged ,Skin ,Aged, 80 and over ,Digital device ,medicine.diagnostic_test ,business.industry ,Health Insurance Portability and Accountability Act ,Middle Aged ,Medical photography ,Identification (information) ,Computers, Handheld ,030220 oncology & carcinogenesis ,Skin biopsy ,Female ,business - Abstract
Background Various means to facilit ate accurate biopsy site identification have been proposed. Objective To determine the accuracy of biopsy site identification by using photographs taken with a patient's digital device by a dermatologist versus professional medical photography. Methods Photographs of circled biopsy sites were taken with personal digital devices by the principal investigator (PI). Another set of photographs was taken by a professional photographer. Secondary photographs were taken of the biopsy site location pointed to by the staff and PI on the basis of the personal digital device image and professional medical photography, respectively. On the basis of secondary photographs, 2 independent dermatologists determined whether the skin biopsy locations pointed out by the staff were consistent with the ones pointed out by PI. Results Per dermatologist A, the staff correctly identified all 53 biopsy sites. Per dermatologist B, the staff were correct on 51 of 53 observations. Dermatologist C, the final arbiter, concurred with dermatologist A on the 2 cases in which dermatologist B was not certain of the location of the biopsy site. Limitations The mean interval from initial biopsy to reidentification of the site was 36.2 days. Conclusion Utilizing patients' personal digital devices is a cost-effective, Health Insurance Portability and Accountability Act–compliant, and readily available means to identify skin biopsy sites.
- Published
- 2018
9. Pseudo-Bullous Dermatosis Induced by Topical Anesthetic Agent—Clues to This Localized Toxic Reaction
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John R. Griffin, Christopher R. Kieliszak, Tess H. Pollinger, and Jacqueline M. Junkins-Hopkins
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medicine.medical_specialty ,Pathology ,Biopsy ,H&E stain ,Dermatology ,Topical anesthetic ,Pallor ,Prilocaine ,Pathology and Forensic Medicine ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Psoriasis ,Bulla (seal) ,Lidocaine, Prilocaine Drug Combination ,Psoriasiform Dermatitis ,Skin Diseases, Vesiculobullous ,medicine.diagnostic_test ,business.industry ,Infant ,Lidocaine ,General Medicine ,medicine.disease ,030220 oncology & carcinogenesis ,Female ,Drug Eruptions ,medicine.symptom ,business ,Spongiosis ,medicine.drug - Abstract
Eutectic mixture of 2.5% lidocaine and 2.5% prilocaine (EMLA AstraZeneca, DE) is a widely used topical anesthetic cream for preprocedural cutaneous analgesia. In addition to potential clinical cutaneous and systemic adverse effects, EMLA may also induce microscopic changes detectable by light and electron microscopy leading to difficulty in accurate diagnosis. We report the case of a biopsy demonstrating EMLA-induced histopathologic changes. The biopsy was taken from the back of a 5-month-old infant and submitted to rule out psoriasis. Hematoxylin and eosin (H&E) staining of the biopsy demonstrated spongiosis and a noninflammatory subepidermal bulla, raising the histopathologic possibility of epidermolysis bullosa. Further investigation confirmed that EMLA was applied under occlusion before biopsy. A second biopsy without topical anesthetic did not demonstrate a bulla and supported the clinical diagnosis of psoriasiform dermatitis. Our case highlights the importance of awareness of EMLA-induced histopathologic changes to avoid potential misdiagnosis. The histopathologic findings of this case in conjunction with other previously reported cases of EMLA-induced bullae were analyzed. Vacuolization of the basal and suprabasilar layer, pallor and swelling of upper layer epidermal keratinocytes, a pauci-inflammatory cleavage beneath or within the basal layer, basophilic granular karyorrhectic debris in the subepidermal cleft, and congestion of papillary dermal vessels characterized the biopsy findings of this localized adverse reaction.
- Published
- 2017
10. Use of Candida antigen injections for the treatment of verruca vulgaris: A two-year mayo clinic experience
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Ali Alikhan, Catherine C. Newman, and John R. Griffin
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Adult ,Pathology ,medicine.medical_specialty ,Antigens, Fungal ,medicine.medical_treatment ,Dermatology ,Injections, Intralesional ,Treatment results ,Immunocompromised Host ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,CANDIDA ANTIGEN ,medicine ,Humans ,Adverse effect ,Common warts ,Candida ,Retrospective Studies ,business.industry ,Retrospective cohort study ,Immunotherapy ,medicine.disease ,Treatment Outcome ,030220 oncology & carcinogenesis ,Female ,Warts ,business ,Verruca Vulgaris - Abstract
Common warts (verruca vulgaris) are one of the most common problems encountered in dermatology and may present a difficult treatment dilemma, as no particular therapy has demonstrated complete efficacy. Intralesional injection of purified Candida antigen has produced impressive treatment results in small prospective and retrospective studies and is thought to produce its effect through stimulation of a cell-mediated immune response. We report a retrospective study of adult and pediatric patients treated with Candida antigen therapy in clinical practice. Of the 100 patients treated, 80% responded to therapy: 39% demonstrated a complete response and 41% demonstrated a partial response. In addition, 6 out of 7 immunocompromised patients who were treated demonstrated a partial or complete response. Injections were generally well-tolerated and adverse events were minimal and short-lived. Our data indicate that intralesional Candida antigen therapy for cutaneous warts is an efficacious option in a clinical practice setting. The treatment may also be effective in immunosuppressed patients with cutaneous warts. Our results add to the literature one of the largest retrospective series reported to date and treatment outcomes are similar to previously reported studies evaluating this therapeutic modality.
- Published
- 2015
11. Cutaneous microemboli from hydrophilic polymer after endovascular procedures
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Margot S. Peters, Michael J. Camilleri, Mark D.P. Davis, Agnieszka K. Thompson, Michael B. Chang, Lawrence E. Gibson, Marian T. McEvoy, Alina G. Bridges, Rokea A. el-Azhary, and John R. Griffin
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Male ,medicine.medical_specialty ,Catheters ,Polymers ,medicine.medical_treatment ,Embolism ,Population ,Dermatology ,Skin Diseases ,Sampling Studies ,Coated Materials, Biocompatible ,medicine ,Humans ,cardiovascular diseases ,Embolization ,education ,Aged ,Retrospective Studies ,Microvascular occlusion ,Aged, 80 and over ,education.field_of_study ,business.industry ,Biopsy, Needle ,Endovascular Procedures ,Soft tissue ,Livedo racemosa ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,Surgery ,Purpura ,cardiovascular system ,Female ,medicine.symptom ,Differential diagnosis ,business - Abstract
Background Multiple devices and coatings assist with endovascular insertion of sheaths, catheters, and guide wires. Hydrophilic polymer coatings, a common component of endovascular surgical devices, reportedly cause microvascular obstruction and embolization, with various sequelae in organs and soft tissue. Objective We sought to describe clinical and histopathologic features of cutaneous manifestations of hydrophilic polymer gel emboli. Methods We evaluated the clinical and histopathologic characteristics of 8 patients with cutaneous complications of hydrophilic polymer gel emboli who presented in May 2013 through February 2015. Results Sudden onset of lower extremity livedo racemosa, purpuric patches, or both, occurred hours to days after endovascular procedures involving the aorta. Histopathologic evaluation showed basophilic lamellated material, consistent with hydrophilic polymer gel emboli, within small dermal vessels. Limitations This was a retrospective study with small sample size and not controlled for all similar procedures in this population. Conclusion Hydrophilic polymer gel coatings in endovascular devices can embolize to skin and cause microvascular occlusion, presenting as livedo racemosa, purpura, or both. Given the number of patients observed over a short period, this phenomenon may be underappreciated. Hydrophilic polymer gel emboli should be considered in differential diagnosis of livedo racemosa and purpura after endovascular procedure.
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- 2015
12. Umbilical and periumbilical dermatoses
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Megha M. Tollefson, John R. Griffin, Tess H. Pollinger, and Christopher R. Kieliszak
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,Umbilicus (mollusc) ,Dermatology ,Risk Assessment ,Skin Diseases ,Sister Mary Joseph nodule ,Congenital Abnormalities ,Sex Factors ,Infectious Epidemiology ,Sex factors ,medicine ,Humans ,Skin Diseases, Infectious ,Child ,Anatomic Location ,Umbilicus ,business.industry ,Incidence ,Age Factors ,Infant, Newborn ,Middle Aged ,Prognosis ,body regions ,Female ,medicine.symptom ,business - Abstract
The umbilicus may be the site of congenital and acquired malformations and may harbor clinical clues to the diagnosis of potentially fatal inherited disorders, primary skin conditions, and a variety of infectious diseases. Both benign and malignant tumors may involve the umbilicus, and some are unique to this site. Finally, cutaneous signs localized to this anatomic location may be found in diverse systemic diseases.
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- 2015
13. Cellular dermatofibroma: A hyperkeratotic indurated plaque on the thigh
- Author
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John R. Griffin, Shyam B Verma, Dirk M. Elston, and Amira Elbendary
- Subjects
medicine.medical_specialty ,business.industry ,Thigh ,lcsh:RL1-803 ,Cases from Ackerman Academy ,Dermatofibroma ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine ,lcsh:Dermatology ,business - Published
- 2016
14. Validity of skin cancer malignancy reporting to the Organ Procurement Transplant Network: A cohort study
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Giorgia L. Garrett, Joyce T. Yuan, Thuzar M. Shin, Sarah T. Arron, Oscar Colegio, Clara Curiel, John R. Griffin, Conway C. Huang, Anokhi Jambusaria, Shang I. Brian Jiang, Justin J. Leitenberger, Rajiv I. Nijhawan, Shari Ochoa, Edit B. Olasz, Clark Otley, Arisa Elena Ortiz, Vishal Anil Patel, Melissa Pugliano-Mauro, Chrysalyne D. Schmults, Sarah E. Schram, Thuzar Shin, Seaver Soon, Teresa Soriano, Divya Srivastava, Jennifer Stein, Kara Sternhell-Blackwell, Stan Taylor, Allison Vidimos, and Peggy Wu
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Oncology ,Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Tissue and Organ Procurement ,Databases, Factual ,Population ,Dermatology ,030230 surgery ,Malignancy ,Organ transplantation ,Cohort Studies ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine ,Prevalence ,Humans ,Registries ,education ,Melanoma ,education.field_of_study ,business.industry ,Incidence ,Odds ratio ,Organ Transplantation ,Middle Aged ,medicine.disease ,Transplant Recipients ,United States ,Cancer registry ,Surgery ,Data Accuracy ,Cohort ,Carcinoma, Squamous Cell ,Female ,Skin cancer ,business ,Cohort study - Abstract
Background The Organ Procurement Transplant Network (OPTN) registry collects data on posttransplant malignancies in solid organ transplant recipients. Complete and accurate registry data on skin cancer is critical for research on epidemiology and interventions. Objective The study goal was to determine the validity of Organ Procurement Transplant Network skin cancer data. Methods This cohort study compared reporting of posttransplant squamous cell carcinoma (SCC) and malignant melanoma (MM) in OPTN to medical-record review-derived data from the Transplant Skin Cancer Network (TSCN) database. In total, 4934 organ transplant recipients from the TSCN database were linked to patient-level OPTN malignancy data. We calculated sensitivity, specificity, correct classification (CC), positive predictive value (PPV), and negative predictive value (NPV) for SCC and MM reporting in the OPTN database. Results OPTN reporting for SCC (population prevalence 11%) had sensitivity 41%, specificity 99%, PPV 88%, NPV 93%, and CC 93%. OPTN reporting for MM (population prevalence 1%) had sensitivity 22%, specificity 100%, PPV 73%, NPV 99%, and CC 99%. Limitations Only a subset of patients in the TSCN cohort had matched United Network for Organ Sharing cancer registry data for comparison. Conclusion OPTN reporting had poor sensitivity but excellent specificity for SCC and MM. Dermatologists and transplant physicians are encouraged to improve the validity of OPTN skin cancer data through improved communication and reporting.
- Published
- 2017
15. Decreased Expression of Intercellular Adhesion Molecules in Acantholytic Squamous Cell Carcinoma Compared With Invasive Well-Differentiated Squamous Cell Carcinoma of the Skin
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Julia S. Lehman, Margot S. Peters, John R. Griffin, and Cooper C. Wriston
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Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Desmoglein ,Syndecan 1 ,Cell membrane ,Biomarkers, Tumor ,medicine ,Humans ,Neoplasm Invasiveness ,Chemistry ,Cell adhesion molecule ,Cadherin ,Acantholysis ,Cell Differentiation ,General Medicine ,medicine.disease ,Immunohistochemistry ,Staining ,stomatognathic diseases ,medicine.anatomical_structure ,Carcinoma, Squamous Cell ,Female ,Cell Adhesion Molecules - Abstract
Intercellular adhesion proteins are poorly characterized in acantholytic squamous cell carcinoma (ASCC), a more aggressive tumor than nonacantholytic invasive well-differentiated squamous cell carcinoma (SCC) of the skin. In this study we compared expression of Dsg3, E-cadherin, and syndecan-1 in ASCC and SCC. Immunohistochemical detection of Dsg3, E-cadherin, and syndecan-1 in 22 ASCCs and 22 SCCs was graded on a semiquantitative scale for intensity of staining (SI) and degree of circumferential staining (CS) about the cell membrane. Results were assessed by means of conditional logistic regression and χ2 analysis. Dsg3 and E-cadherin expression (SI, CS) was significantly decreased (P < .05) in ASCC compared with SCC, whereas staining for syndecan-1 was similar in the 2 tumor types. Differences in expression of adhesion markers between ASCC and SCC may contribute to the development of acantholysis in ASCC and its more aggressive biologic behavior.
- Published
- 2013
16. Defining 'Lichen': From Greek Mycology to Modern Dermatology
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Daniel Zaghi and John R. Griffin
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Lichen - organism ,medicine.medical_specialty ,Lichenoid Eruptions ,Greece ,business.industry ,MEDLINE ,Historical Article ,Lichen disease ,History, 19th Century ,Dermatology ,Mycology ,History, 18th Century ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Medicine ,Lichen ,business ,History, Ancient - Published
- 2016
17. A novel classification system for dysplastic nevus and malignant melanoma
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Mutlu Mete, Nikolay Metodiev Sirakov, John R. Griffin, and Alan Menter
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,business.industry ,Melanoma ,medicine.disease ,Decision maker ,Malignancy ,Lesion ,Melanoma detection ,03 medical and health sciences ,030104 developmental biology ,Mole ,medicine ,Dysplastic nevus ,Skin cancer ,medicine.symptom ,business - Abstract
Melanoma is a potentially deadly form of skin cancer, however, if detected early, it is curable. A dysplastic nevus (atypical mole) is not cancerous but may represent a precursor to malignancy as nearly 40% of melanomas arise from a preexisting mole. In this study, we propose a system to classify a skin lesion image as melanoma (M), dysplastic nevus (D), and benign (B). For this purpose we develop a new two layered-system. The first layer consists of three binary Support Vector Machine (SVM) classifiers, one for each pair of classes, M vs B, M vs D, and B vs D. The second layer is a novel decision maker function, which uses probability memberships derived from the first layer. Each lesion is characterized with five features, which mostly overlaps with the ABCD rule of dermatology. The dataset we used have 112 lesions with 54 M, 38 D, and 20 B cases. In the experiments of melanoma detection, we obtained 98% specificity, 76% sensitivity, and 85% F-measure accuracy.
- Published
- 2016
18. Image Gallery: Cutaneous T-cell lymphoma mimicking a gyrate erythema
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Jeffrey D. Cizenski, John R. Griffin, and Alan Menter
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Male ,medicine.medical_specialty ,Skin Neoplasms ,business.industry ,Cutaneous T-cell lymphoma ,Dermatology ,medicine.disease ,Lymphoma, T-Cell, Cutaneous ,Diagnosis, Differential ,Young Adult ,Erythema ,Gyrate erythema ,Medicine ,Humans ,business - Published
- 2016
19. Radiation-induced localized bullous pemphigoid in a patient with breast carcinoma
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Bobbak Mansouri, John R Griffin, Barry Wilcox, and Molly Campa
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medicine.medical_specialty ,Pemphigoid ,medicine.medical_treatment ,External beam radiation ,Brachytherapy ,Radiation induced ,Breast Neoplasms ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Pemphigoid, Bullous ,medicine ,Carcinoma ,Humans ,Radiation Injuries ,skin and connective tissue diseases ,Prior Radiation Therapy ,Skin ,Aged, 80 and over ,integumentary system ,business.industry ,Carcinoma, Ductal, Breast ,General Medicine ,medicine.disease ,eye diseases ,030220 oncology & carcinogenesis ,Female ,Bullous pemphigoid ,Breast carcinoma ,business ,bullous pemphigoid, radiation therapy, brachytherapy, breast cancer - Abstract
Bullous pemphigoid (BP) is a common pemphigoid disorder, which is localized in approximately 16-29% of cases. A small subset of localized BP cases is associated with prior radiation therapy, most commonly for breast carcinoma. We present a patient with an unusual presentation of localized BP after receiving partial accelerated breast irradiation (a type of brachytherapy that has a decreased amount of radiation to the skin as compared to the more common external beam radiation therapy).
- Published
- 2016
20. Lymphangioma-like classic Kaposi sarcoma
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John R. Griffin and Brian L. Scott
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medicine.medical_specialty ,Classic Kaposi Sarcoma ,business.industry ,Dermatology ,medicine.disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Lymphangioma ,medicine ,Sarcoma ,business - Published
- 2017
21. CARDINAL NEWMAN AND THE ECLECTIC HERESY
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John R. Griffin
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Philosophy ,Heresy ,Catholic theology ,media_common.quotation_subject ,Religious studies ,media_common - Published
- 2011
22. CARDINAL NEWMAN AND THE ORIGINS OF VICTORIAN SKEPTICISM
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John R. Griffin
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Faith ,Philosophy ,Protestantism ,media_common.quotation_subject ,Catholic theology ,Religious studies ,Theology ,Rationalism (international relations) ,Skepticism ,media_common - Abstract
Poor Oxford, torn first by Romanism scarcely disguised, and next by Rationalism quite as naked! Church of the Reformation, ancient bulwark of the Protestant faith! Strange children are nurtured in thy bosom.British and Foreign Evangelical Review (Jan. 1856).
- Published
- 2008
23. Basal cell carcinoma in childhood: Case report and literature review
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Bruce R. Nelson, Keith E. Schulze, John R. Griffin, Jaime A. Tschen, Philip R. Cohen, Elizabeth A. Mullans, and Paul T. Martinelli
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Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Xeroderma pigmentosum ,business.industry ,Nose Neoplasms ,Histology ,Dermatology ,Mohs Surgery ,medicine.disease ,Treatment Outcome ,El Niño ,Carcinoma, Basal Cell ,Nevus sebaceus ,Albinism ,Humans ,Medicine ,Nevus ,Basal cell carcinoma ,Sun exposure ,Child ,business - Abstract
Childhood onset basal cell carcinoma is uncommon. In addition to occurring in children with albinism, Bazex syndrome, basal cell carcinoma nevus syndrome, nevus sebaceus, radiotherapy-treated cancers, solid organ transplants, and xeroderma pigmentosum, childhood onset basal cell carcinoma has also occurred, albeit less commonly, de novo. We describe a boy with idiopathic childhood onset basal cell carcinoma. Previously published children with de novo basal cell carcinoma were collected from computerized medical literature search (PubMed) and citations from earlier reports. To our knowledge, childhood onset idiopathic basal cell carcinoma has been observed in a total of 107 children, including our patient. Tumors were most commonly located on the head (90%). The tumors are most frequently nodular in appearance (52%) and in histology (at least 17%); however, aggressive histologic variants were observed in 20% of tumors. Basal cell carcinoma in children may be associated with prior sun exposure. The most common treatment is excision, with or without using the Mohs technique. However, 15 of 85 children, nearly 20%, developed recurrent tumors during a follow-up period ranging from 4 months to 20 years.
- Published
- 2007
24. Acral vesicles and bullae in a patient with severe rheumatoid arthritis
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John R. Griffin and Gabriela M. Soza
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Pathology ,medicine.medical_specialty ,business.industry ,Arthritis ,General Medicine ,medicine.disease ,Dermatology ,humanities ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Case Studies ,Neutrophilic dermatosis ,030220 oncology & carcinogenesis ,Rheumatoid arthritis ,medicine ,Certolizumab pegol ,business ,medicine.drug - Abstract
We present the case of a 56-year-old black woman with rheumatoid arthritis who developed worsening fatigue, fever, weight loss, and a vesiculobullous skin eruption while being treated with certolizumab pegol for her arthritis. Microscopic findings confirmed the diagnosis of a neutrophilic dermatosis.
- Published
- 2015
25. Assessment of Health Risk from Historical Use of Cosmetic Talcum Powder
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Elizabeth L, Anderson, Patrick J, Sheehan, Renee M, Kalmes, and John R, Griffin
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Mineral Fibers ,Inhalation Exposure ,Air ,Respiration ,X-Rays ,Asbestos ,Cosmetics ,Risk Assessment ,Microscopy, Electron, Transmission ,Talc ,Occupational Exposure ,Thermogravimetry ,Humans ,Microscopy, Phase-Contrast ,Powders ,Probability - Abstract
This study's objective is to assess the risk of asbestos-related disease being contracted by past users of cosmetic talcum powder. To our knowledge, no risk assessment studies using exposure data from historical exposures or chamber simulations have been published. We conducted activity-based sampling with cosmetic talcum powder samples from five opened and previously used containers that are believed to have been first manufactured and sold in the 1960s and 1970s. These samples had been subject to conflicting claims of asbestos content; samples with the highest claimed asbestos content were tested. The tests were conducted in simulated-bathroom controlled chambers with volunteers who were talc users. Air sampling filters were prepared by direct preparation techniques and analyzed by phase contrast microscopy (PCM), transmission electron microscopy (TEM) with energy-dispersive x-ray (EDX) spectra, and selective area diffraction (SAED). TEM analysis for asbestos resulted in no confirmed asbestos fibers and only a single fiber classified as "ambiguous." Hypothetical treatment of this fiber as if it were asbestos yields a risk of 9.6 × 10
- Published
- 2015
26. Ulcerated draining plaque below stoma
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Elliott Call, John R. Griffin, and Jeffrey D. Cizenski
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medicine.medical_specialty ,medicine.medical_treatment ,Dermatology ,Gastroenterology ,Abdominal wall ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Ileostomy ,0302 clinical medicine ,Intestinal mucosa ,Stoma (medicine) ,Crohn Disease ,Internal medicine ,Metaplasia ,Skin Ulcer ,medicine ,Humans ,Intestinal Mucosa ,business.industry ,Crohn disease ,Abdominal Wall ,Skin ulcer ,Middle Aged ,Surgery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,business - Published
- 2015
27. Amitriptyline/Ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster
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John R, Griffin and Mark D P, Davis
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Male ,Analgesics ,Drug Combinations ,Amitriptyline ,Pruritus ,Humans ,Neuralgia, Postherpetic ,Ketamine ,Middle Aged ,Administration, Cutaneous ,Gels ,Herpes Zoster - Abstract
Frequent causes of morbidity secondary to herpes zoster include acute pain, secondary infection, and postherpetic neuralgia. A less documented complication is pruritus, which can be either acute or postinfectious when it persists more than 3 months after the rash has healed. We discuss a case of severe, acute neuropathic pruritus and pain secondary to active herpes zoster that was unresponsive to standard medical therapy, including oral antihistamines, topical lidocaine, oral gabapentin, and local wound care. Modest control of the pruritus and pain was achieved with continued multimodal therapy and the addition of topical 2% amitriptyline/0.5% ketamine gel.
- Published
- 2015
28. Simple Method for Microscopic Confirmation of Previous Biopsy Site
- Author
-
John R. Griffin and Connie Tran
- Subjects
medicine.medical_specialty ,Biopsy ,Hemorrhage ,Dermatology ,Hemostatics ,Pathology and Forensic Medicine ,Chlorides ,Biopsy Site ,Predictive Value of Tests ,Aluminum Chloride ,Humans ,Medicine ,Aluminum Compounds ,Skin pathology ,Skin ,Simple (philosophy) ,medicine.diagnostic_test ,business.industry ,Granuloma, Foreign-Body ,General Medicine ,Middle Aged ,medicine.disease ,Predictive value of tests ,Granuloma ,Female ,Radiology ,business - Published
- 2016
29. Merrigan, Terrence & Ian Ker, eds. Newman and Truth
- Author
-
John R. Griffin
- Published
- 2012
30. Rhinophyma: Review and Update
- Author
-
William P. Adams, Rod J. Rohrich, and John R. Griffin
- Subjects
Male ,medicine.medical_specialty ,business.industry ,Diagnostico diferencial ,Rhinophyma ,Middle Aged ,Dermatology ,Anti-Bacterial Agents ,Surgery ,Diagnosis, Differential ,Retinoids ,Laser therapy ,Dermabrasion ,Rosacea ,medicine ,Humans ,Female ,Laser Therapy ,medicine.symptom ,business ,Algorithms - Abstract
After studying this article, the participant should be able to discuss: 1. Clinical features and anatomy of rhinophyma. 2. The etiology and epidemiology of rhinophyma. 3. Associated diagnosis that can complicate rhinophyma. 4. Common nonsurgical and surgical therapies for rhinophyma. 5. A safe and integrated treatment plan for the patient with rhinophyma.
- Published
- 2002
31. Incidence of and Risk Factors for Skin Cancer in Organ Transplant Recipients in the United States
- Author
-
Shlomo A. Koyfman, Sarah T. Arron, Clara Curiel-Lewandrowski, Kathryn Konicke, Kristin Bibee, Chrysalyne D. Schmults, Joyce Y. Cheng, Allison T. Vidimos, Arisa E. Ortiz, Tiffany Y Loh, Caroline R. Morris, Andrew Breithaupt, Zelma Chiesa-Fuxench, Shang I Brian Jiang, Allen F. Shih, Jeremy Oulton, Kara Sternhell-Blackwell, Daniel E. Zelac, Melissa Pugliano-Mauro, Peggy A. Wu, Tiffany Anthony, Spring Golden, Shari A. Ochoa, Robert E. Eilers, Parth Patel, Charlene Lam, Conway C. Huang, Peter K. Lee, Vishal A. Patel, Shilpi Khetarpal, Thomas A. Jennings, Pritesh S. Karia, Jennifer A. Stein, Rajiv I. Nijhawan, Margaret Dowd, Arpan V. Prabhu, Reshmi Madankumar, Michael S. Graves, Elaine Otchere, Stan Taylor, Paul D. Blanc, Gordon H. Bae, Christina A. Del Guzzo, Sarah E. Schram, Jacqueline F. Moreau, Teresa Soriano, Rehana L. Ahmed, R. Samuel Hopkins, Edit Olasz, Goran B. Klintmalm, Divya Srivastava, Oscar R. Colegio, Thuzar M. Shin, John R. Griffin, Justin J. Leitenberger, Changhyun Kim, Giorgia L. Garrett, Seaver L. Soon, Nicholas Zajdel, Amanda Abramson Lloyd, Clark C. Otley, Anokhi Jambusaria, John Boscardin, Jennifer Cannon, Amy Chen, Stefan E. Lowenstein, and Max Disse
- Subjects
Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Adolescent ,Population ,Dermatology ,White People ,Organ transplantation ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Humans ,Medicine ,education ,Melanoma ,Aged ,Retrospective Studies ,education.field_of_study ,business.industry ,Merkel cell carcinoma ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,Age Factors ,Retrospective cohort study ,Organ Transplantation ,Middle Aged ,medicine.disease ,United States ,Surgery ,Carcinoma, Merkel Cell ,Transplantation ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Female ,Skin cancer ,business ,Follow-Up Studies - Abstract
Importance Skin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin cancer in solid organ transplant recipients (OTRs), no study has estimated the posttransplant population–based incidence in the United States. Objective To determine the incidence and evaluate the risk factors for posttransplant skin cancer, including squamous cell carcinoma (SCC), melanoma (MM), and Merkel cell carcinoma (MCC) in a cohort of US OTRs receiving a primary organ transplant in 2003 or 2008. Design, Setting, and Participants This multicenter retrospective cohort study examined 10 649 adult recipients of a primary transplant performed at 26 centers across the United States in the Transplant Skin Cancer Network during 1 of 2 calendar years (either 2003 or 2008) identified through the Organ Procurement and Transplantation Network (OPTN) database. Recipients of all organs except intestine were included, and the follow-up periods were 5 and 10 years. Main Outcomes and Measures Incident skin cancer was determined through detailed medical record review. Data on predictors were obtained from the OPTN database. The incidence rates for posttransplant skin cancer overall and for SCC, MM, and MCC were calculated per 100 000 person-years. Potential risk factors for posttransplant skin cancer were tested using multivariate Cox regression analysis to yield adjusted hazard ratios (HR). Results Overall, 10 649 organ transplant recipients (mean [SD] age, 51 [12] years; 3873 women [36%] and 6776 men [64%]) contributed 59 923 years of follow-up. The incidence rates for posttransplant skin cancer was 1437 per 100 000 person-years. Specific subtype rates for SCC, MM, and MCC were 812, 75, and 2 per 100 000 person-years, respectively. Statistically significant risk factors for posttransplant skin cancer included pretransplant skin cancer (HR, 4.69; 95% CI, 3.26-6.73), male sex (HR, 1.56; 95% CI, 1.34-1.81), white race (HR, 9.04; 95% CI, 6.20-13.18), age at transplant 50 years or older (HR, 2.77; 95% CI, 2.20-3.48), and being transplanted in 2008 vs 2003 (HR, 1.53; 95% CI, 1.22-1.94). Conclusions and Relevance Posttransplant skin cancer is common, with elevated risk imparted by increased age, white race, male sex, and thoracic organ transplantation. A temporal cohort effect was present. Understanding the risk factors and trends in posttransplant skin cancer is fundamental to targeted screening and prevention in this population.
- Published
- 2017
32. Biopsy diagnoses of clinically atypical pigmented lesions of the head and neck in adults
- Author
-
John R. Griffin, Olga Udovenko, and Dirk M. Elston
- Subjects
Adult ,Male ,medicine.medical_specialty ,Skin Neoplasms ,Biopsy ,Dermatology ,Pathology and Forensic Medicine ,Diagnosis, Differential ,Young Adult ,medicine ,Humans ,Young adult ,skin and connective tissue diseases ,neoplasms ,Melanoma ,Aged ,Aged, 80 and over ,integumentary system ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,Incidence ,General Medicine ,Cheek ,Middle Aged ,medicine.disease ,Atypical nevus ,medicine.anatomical_structure ,Head and Neck Neoplasms ,Forehead ,Dysplastic nevus ,Female ,business ,Dysplastic Nevus Syndrome - Abstract
A subset of facial melanoma in situ has histological features that overlap with those of "dysplastic" nevi. The authors evaluated this important diagnostic pitfall by assessing the frequency of melanoma as the final diagnosis in skin biopsies submitted over a 1-year period with a clinical impression of "atypical" or dysplastic nevus from the head or neck of adults. A total of 1998 biopsies met inclusion criteria. Final diagnoses included both melanocytic and nonmelanocytic processes. Clear trends were noted based on the age of the patient with benign nevi encompassing nearly 70% of specimens in patients aged 21-29 years and
- Published
- 2014
33. The asymmetrical nasal tip in primary rhinoplasty
- Author
-
Rod J. Rohrich and John R. Griffin
- Subjects
Suturing techniques ,Otorhinolaryngology ,Lateral cartilage ,business.industry ,medicine.medical_treatment ,Deformity ,medicine ,Anatomy ,medicine.symptom ,Nasal tip ,business ,Rhinoplasty - Abstract
An analysis of nasal tip asymmetry is proposed that focuses on intrinsic deformities of the lower lateral cartilages. Three types of intrinsic deformities of the lower lateral cartilages are recognized that result in asymmetrical domal projection and lateral domal deviation. The most common deformity involves ipsilateral middle crural convexity and contralateral concavity. The second problem is caused by different lengths of paired medial crura. The third form of tip asymmetry is caused by a unilateral splayed lower lateral cartilage that is further from the anatomic midline than the opposite lower lateral cartilage. The use of suturing techniques and occasional grafts to restore nasal tip symmetry is described in each of the three scenarios.
- Published
- 2000
34. Factors Predictive of Quality of Life after Silicone-Implant Explantation
- Author
-
Jack B. Robinson, Rod J. Rohrich, Ranganathan Rathakrishnan, and John R. Griffin
- Subjects
Reoperation ,medicine.medical_specialty ,Breast Implants ,MEDLINE ,law.invention ,Silicone Gels ,Quality of life ,law ,Surveys and Questionnaires ,Humans ,Medicine ,Medical diagnosis ,Breast Implantation ,Retrospective Studies ,business.industry ,General surgery ,Medical record ,Retrospective cohort study ,Silicone implant ,Surgery ,Breast implant ,Quality of Life ,Female ,business ,Complication ,Attitude to Health - Abstract
'Medical records of 180 patients who underwent silicone gel-filled breast implant explanation were retrospectively reviewed. The goal of this study was to determine if any patient variable(s) had predictive value for positive quality of life after explanation. The medical complaints, symptoms, and established diagnoses were considered equally and were referred to as self-reported medical problems. The study revealed that no single problem or pairing of problems was associated with or predictive of outcome. The results show, however, that the number of medical problems was significantly predictive of patient perception of quality of life. A total of 50 explanation patients completed quality-of-life surveys. Specifically, those patients who reported five or fewer medical problems that predated explantation were significantly more likely to perceive an increased quality of life after surgery than those who reported nine or more medical problems (p < 0.04). In conclusion, it is difficult to correlate subjective patient symptoms with postoperative improvements in quality of life after explantation.
- Published
- 1999
35. The Myoadipose Flap: A New Composite
- Author
-
William P. Adams, John R. Griffin, Ronald M. Friedman, Rod J. Rohrich, and Jack B. Robinson
- Subjects
Surgery - Published
- 1998
36. A Laboratory Exercise in Mineral Thermodynamics
- Author
-
Nancy Lindsley-Griffin, John R. Griffin, and Glenn B. Stracher
- Subjects
Mathematical skill ,ComputingMilieux_COMPUTERSANDEDUCATION ,Mathematics education ,General Earth and Planetary Sciences ,Thermodynamics ,Mineral identification ,Education ,Variety (cybernetics) ,Mathematics - Abstract
Geology students should learn mathematical skills early in their academic careers. Enhancing proficiency in mathematics opens up new learning possibilities, including mineral thermodynamics. Laboratory exercises can effectively teach students important scientific principles requiring the application of mathematics. With basic mathematical skills, students can learn to perform a variety of thermodynamic calculations. Consequently, mineralogy students and students enrolled in freshman honors geology can be exposed to more than mineral identification, crystal symmetry, phase diagrams, and other traditional topics.
- Published
- 1998
37. Brief Notices
- Author
-
Thomas F. Madden, Ann M. Harrington, Joseph C. Linck, Richard E. Sullivan, Bennett Hill, and John R. Griffin
- Subjects
General Arts and Humanities - Published
- 1998
38. The Catholic Revival in English Literature, 1845–1961. By Ker Ian. Notre Dame, Ind.: Notre Dame University Press, 2003. xii. + 231 pp. $60.00 cloth; $25.00 paper
- Author
-
John R. Griffin
- Subjects
Cultural Studies ,History ,English literature ,Religious studies ,Media studies - Published
- 2005
39. List of Contributors
- Author
-
Stuart J. Day, Yevgeny Vapnik, Hamed Sanei, Jesse Carrie, Fari Goodarzi, Glenn B. Stracher, Claudia Kuenzer, Christoph Hecker, Jianzhong Zhang, Paul A. Schroeder, John K. McCormack, Jhon A. Quintero, Carlos A. Ríos, Zdenek Klika, Petr Martinec, M. Naze-Nancy Masalehdani, Yves Paquette, Frank de Wit, Thomas Witzke, Uwe Kolitsch, Günter Blaß, Anupma Prakash, Rudiger Gens, Sheochandra Prasad, Ashwani Raju, Ravi P. Gupta, Alfred E. Whitehouse, Asep A.S. Mulyana, Jacob Vardi, Giovanni Martinelli, Stefano Cremonini, Eleonora Samonati, Ilia L. Fishman, Yuliya I. Kazakova, Oleg P. Polyansky, Yelena White, Kalik O. Bajadilov, Magdalena Misz-Kennan, Justyna Ciesielczuk, Adam Tabor, Joana Ribeiro, Rui Moura, Deolinda Flores, Duarte B. Lopes, Carlos Gouveia, Sérgio Mendonça, Orlando Frazão, Sorin-Corneliu Rădan, Silviu Rădan, Ellina V. Sokol, Sophia A. Korzhova, Svetlana N. Kokh (Zateeva), Victor V. Sharygin, Ekaterina A. Simonova, Tatyana Minayeva, Andrey A. Sirin, Keith W. Torrance, Christine Switzer, Guillermo Rein, Richard Carvel, Rory Hadden, Claire M. Belcher, Robert B. Finkelman, Denis Pone, Harold Annegarn, Donald R. Blake, Luis Moreno, M. Emilia Jiménez, Russell H. Bartley, Sylvia E. Bartley, Richard E. Carroll, Nancy Lindsley-Griffin, John R. Griffin, Edward L. Heffern, John K. Hiett, James C. Hower, Sarah M. Mardon, Melissa A. Bannes (Nolter), John Styers, Manuel Martínez, Gonzalo Márquez, J. Denis N. Pone, Karen M. McCurdy, Fredrick J. Rich, Lisa LaFosse’, Mark Cummins, Ann G. Kim, Donald Coates, Edward Heffern, Gary Colaizzi, Tammy P. Taylor, Dick Baughman, Melissa A. Barnes (Nolter), Daniel H. Vice, Paul van Dijk, Ben Maathuis, Xiangmin Zhang, Stefan Voigt, Anke Tetzlaf, Zhang Jianzhong, Claudia Künzer, Günter Strunz, Dieter Oertel, Achim Roth, Harald Mehl, Boris Zhukov, Steven Jones, Conri Moolman, Alan Reid, David Glasser, Franco de Andrade, Johan de Korte, Rosemary Falcon, Sezar Uludag, Sydney Ramovha, Dirk Miller, Eddie Dhlamini, John Hiett, Robert B. Finkeman, Jonathan P. Mathews, Kim A.A. Ncube-Hein, Stephen D. Emsbo-Mattingly, Jennifer M.K. O’Keefe, Jan Nel, Peter Peschken, Tom Rogans, Helena Sant’Ovaia, Heloisa Corrêa-Ribeiro, Celeste Gomes, Zhongsheng Li, Colin R. Ward, Brandon Oberweis, Carl Frankel, Peter Reiners, Chris Fleisher, Jimmy Kitson, Larry H. Barwick, Jean-Luc Bouchardon, Bernard Guy, Jean Chalier, Boris Khesin, Itkis Sonya, Reginald Shagam, Margarete Vasterling, Stefan Schloemer, Uwe Meyer, Christian Fischer, Christoph Ehrler, Svetlana N. Kokh, Sofya Korzhova, Yevgeny Kudinov, Nadezhda Kiriltseva, Zenon Różański, Paweł Wrona, Jan Drenda, Grzegorz Pach, Phan Quang Van, Tran van Thanh, Le Van Thao, Mikhail N. Murashko, Zulfiya A. Murashko, Sergey N. Britvin, Scott A. Stout, Mark Engle, Ricardo A. Olea, Allan Kolker, Jennifer Beck, Jana Palmer, Bryan Benton, Ketan Chauhan, William A. Brantley, Allyana Fultz, Shannon Fultz, Joy Hayslip, Roy 'Chris' C. Jones, Jessica Martin, Traci Waters, and Kimberly Thompson
- Published
- 2013
40. Celebrating dermatopathology and art: The First Annual Mayo Clinic Dermatopathology/Immunodermatology Art Competition
- Author
-
Julia S, Lehman and John R, Griffin
- Subjects
Humans ,Dermatology ,Skin Diseases ,Art ,Skin - Published
- 2012
41. Stomatitis, Cutaneous Bullae, and Renal Failure
- Author
-
Connie Tran, Elizabeth Wilder, and John R. Griffin
- Subjects
medicine.medical_specialty ,Biopsy ,Physical examination ,Diagnosis, Differential ,Blister ,Tongue ,medicine ,Humans ,Renal Insufficiency ,Fluorescent Antibody Technique, Indirect ,Stomatitis ,Scalp ,medicine.diagnostic_test ,Soft palate ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Trunk ,Surgery ,medicine.anatomical_structure ,Female ,Chills ,Hard palate ,medicine.symptom ,business ,Pemphigus - Abstract
A64-year-oldAfricanAmericanwomanpresentedtotheemergencydepartmentforevaluationofbleedingmouth sores, tender crustedplaquesonher scalp, andblisters onher skin. Threeweeks previously, she noticed painful erosions throughout hermouth. Aweek later, painfulblistersappearedonherupperextremities, trunk, and thighs. She also reported 2 pruritic and painful lesions on her scalp that had appeared 6 months prior, shortly after a chemical hair treatment. She had a history of alcohol, tobacco, cocaine, andmarijuana use but denied current illicit drug use. She hadnot taken anymedicationsprior to the appearanceof the lesions. Thepatient reported a 2.25-kg weight loss, subjective fevers, and chills but no urinary symptoms. On admission, the patient was tachycardic (113/min), but she was afebrile and other vital signs were normal. Physical examination revealed crusted plaques on her scalp bilaterally (Figure). Erosive stomatitis involving the lower lip, buccal mucosa, hard palate, soft palate, and tongue was noted (Figure). Multiple well-circumscribed, round-to-oval bullae, erosions, and hyperpigmented patches were noted on her upper extremities, trunk, and thighs (Figure). Laboratory evaluation revealed a serum creatinine level of 7.1 mg/dL (627.6 μmol/L), up from a baseline (10 days prior) level of 0.9 mg/dL (79.6 μmol/L). Urinalysis revealed a specific gravity of 1.015 and was positive for hyaline casts and protein but negative for white blood cells, red blood cells, and bacteria. A complete blood cell count was unremarkable. Results of human immunodeficiency virus screen and urine drug screen were normal. Quiz at jama.com Figure. Left, Crusted plaques on scalp of patient. Center, Erosive stomatitis of the lower lip, buccal mucosa, hard palate, soft palate, and tongue. Right, Bullae and erosions on the upper back.
- Published
- 2015
42. Investment and Ownership in a Volatile Economy: Big Banks and the Case of the East German Economic Transition
- Author
-
John R. Griffin
- Subjects
German ,Market economy ,Sociology and Political Science ,Transition (fiction) ,Political Science and International Relations ,language ,Economics ,Investment (macroeconomics) ,Social Sciences (miscellaneous) ,language.human_language - Published
- 1994
43. Genetics Review: Relation to Ocular Disease
- Author
-
John R. Griffin
- Subjects
Male ,Heterozygote ,Eye Diseases ,genetic structures ,Genetic Linkage ,Genetic traits ,Genetic counseling ,Eye disease ,Chromosome Disorders ,Genetic Counseling ,Eye care ,Genetic linkage ,medicine ,Humans ,Ocular disease ,Chromosome Aberrations ,Genetics ,business.industry ,Inheritance (genetic algorithm) ,Heterozygote advantage ,medicine.disease ,eye diseases ,Pedigree ,Ophthalmology ,Female ,sense organs ,business ,Optometry - Abstract
This study is a review of modes of transmission of genetic traits, how they relate to ocular diseases, and abnormalities frequently seen by primary eye care practitioners. Traits showing autosomal dominant (AD), autosomal recessive (AR), X-linked (XR) recessive, chromosomal aberrations, and multifactorial (M) inheritance are listed. General guidelines for genetic counseling are given.
- Published
- 1994
44. Congenital Contracture
- Author
-
Scott H. Kozin, Simon P. Kay, John R. Griffin, and Marybeth Ezaki
- Published
- 2011
45. Contributors
- Author
-
A. Bobby Chhabra, Brian D. Adams, Julie E. Adams, David A. Altchek, Peter C. Amadio, Dimitri J. Anastakis, Edward A. Athanasian, Kodi K. Azari, Donald S. Bae, Mark Bagg, David P. Barei, O. Alton Barron, Michael S. Bednar, Rolfe Birch, Allen T. Bishop, Richard E. Brown, Earl Z. Browne, Michelle Gerwin Carlson, Louis W. Catalano, Kevin C. Chung, George Chloros, Mark S. Cohen, Struan H. Coleman, Timothy R.C. Davis, Charles S. Day, Bassem T. Elhassan, Marybeth Ezaki, Paul Feldon, Lauren Fischer, Marc Garcia-Elias, William B. Geissler, Günter Germann, Richard D. Goldner, Michael Gordon, Thomas J. Graham, David P. Green, John R. Griffin, Ayan Gulgonen, Steven C. Haase, Vidal Haddad, Douglas P. Hanel, Marie-Noëlle Hébert-Blouin, Steven L. Henry, Robert N. Hotchkiss, Larry Hurst, John V. Ingari, Jonathan Isaacs, Michelle A. James, Andrew Jawa, Peter J.L. Jebson, Karen Johnston Jones, Neil F. Jones, Jesse B. Jupiter, Morton L. Kasdan, Leonid I. Katolik, Robert A. Kaufmann, Simon P. Kay, Mary Ann E. Keenan, Graham J.W. King, L. Andrew Koman, Scott H. Kozin, W.P. Andrew Lee, Zhongyu Li, Graham D. Lister, Dean S. Louis, Susan E. Mackinnon, Govind Narain Malaviya, Jonas L. Matzon, David B. McCombe, Kenneth R. Means, Greg Merrell, Richard Meyer, Lewis H. Millender, Edward A. Nalebuff, Christine B. Novak, Shawn W. O'Driscoll, Kagan Ozer, Mukund R. Patel, William C. Pederson, Gary G. Poehling, David Ring, David S. Ruch, Trajano Sardenberg, John Gray Seiler, William H. Seitz, Frances Sharpe, Alexander Y. Shin, Joseph F. Slade, David Slutsky, Beth Paterson Smith, Thomas L. Smith, Nicole Z. Sommer, Robert J. Spinner, John Stanley, Scott P. Steinmann, Peter J. Stern, Milan V. Stevanovic, Robert J. Strauch, John S. Taras, Andrew L. Terrono, James R. Urbaniak, Ann E. Van Heest, Nicholas B. Vedder, Peter M. Waters, Fu-Chan Wei, Gerlinde Weigel, Scott W. Wolfe, and Peter C. Zarkadas
- Published
- 2011
46. Concurrent validity and screening efficiency of The Dyslexia Screener
- Author
-
John R. Griffin, Diana Wright Guerin, Garth N. Christenson, and Allen W. Gottfried
- Subjects
Longitudinal study ,Psychometrics ,Concurrent validity ,Dyslexia ,Validity ,Test validity ,medicine.disease ,Developmental psychology ,Psychiatry and Mental health ,Clinical Psychology ,Convergent validity ,Scale (social sciences) ,medicine ,Psychology - Abstract
The concurrent criterion-related validity and screening efficiency of a recently developed scale, The Dyslexia Screener (TDS), was investigated by examining its relation to the Reading Cluster of the Woodcock-Johnson Psychoeducational Assessment Battery (WJ) in a sample of 100 nonreferred children participating in a longitudinal study
- Published
- 1993
47. Do Tinted Lenses Really Help Students with Reading Disabilities?
- Author
-
Donald N. Cardinal, Garth N. Christenson, and John R. Griffin
- Subjects
050103 clinical psychology ,Medical education ,media_common.quotation_subject ,05 social sciences ,050301 education ,Sensory Aid ,USable ,Education ,Clinical Psychology ,Reading (process) ,Pedagogy ,Developmental and Educational Psychology ,0501 psychology and cognitive sciences ,Psychology ,0503 education ,media_common - Abstract
Distills the body of research on the efficacy of tinted lenses into concise, usable information for teachers, students, and parents
- Published
- 1993
48. Dyslexia and Visual Perception
- Author
-
G F Bateman, T F Birch, P. N. De Land, and John R. Griffin
- Subjects
Male ,Visual perception ,Adolescent ,media_common.quotation_subject ,Vision Disorders ,Dyslexia ,Multivariate analysis of variance ,Reading (process) ,medicine ,Humans ,Language disorder ,Child ,media_common ,Learning Disabilities ,Univariate ,medicine.disease ,Test (assessment) ,Ophthalmology ,Reading ,Visual Perception ,Female ,Analysis of variance ,Psychology ,Optometry ,Cognitive psychology - Abstract
Opinions differ concerning the relation between dyslexia and visual perception. In this pilot study we addressed this question by analyzing the results of visual perceptual testing on 19 elementary grade subjects diagnosed as having dyseidesia, one type of dyslexia that manifests as problems with sight-word recognition. The subjects, who have different degrees of severity of dyseidesia, were compared with 11 subjects tested as nondyslexic, but with reading problems. The Dyslexia Determination Test (DDT) and the Test of Visual Perceptual Skills (TVPS) were given to all subjects. Both multivariate analysis of variance (MANOVA) and univariate one-way analysis of variance (ANOVA) to test for differences in performance among four test groups (ranging from nondyslexic to increasing levels of severity of dyseidesia) showed no trends of either statistical or clinical importance. An individual with reading problems may be nondyslexic but have poor visual perceptual skills, or may be dyslexic with good visual perceptual skills. These results are consistent with the contention that reading problems caused by dyseidesia (as defined by the DDT) and those caused by visual perceptual deficiencies (as defined by the TVPS) are different. Although dyseidetic dyslexia results in characteristic coding patterns producing specific reading problems, it is probable that visual perceptual deficiencies contribute to learning problems that include general reading problems. Each condition would, therefore, require different forms of therapy. Limitations of this study and recommendations for future research are discussed.
- Published
- 1993
49. Nasal reconstruction: an overview and nuances
- Author
-
Fadi C. Constantine, John R. Griffin, and James F. Thornton
- Subjects
Skin care ,medicine.medical_specialty ,business.industry ,Dermabrasion ,medicine.medical_treatment ,Full-thickness skin graft ,Article ,Surgery ,Medicine ,Skin grafting ,Nasolabial flap ,Forehead flap ,business - Abstract
Nasal reconstruction continues to be a formidable challenge for most plastic surgeons. This article provides an overview of nasal reconstruction with brief descriptions of subtle nuances involving certain techniques that the authors believe help their overall outcomes. The major aspects of nasal reconstruction are included: lining, support, skin coverage, local nasal flaps, nasolabial flap, and paramedian forehead flap. The controversy of the subunit reconstruction versus defect-only reconstruction is briefly discussed. The authors believe that strictly adhering to one principle or another limits one's options, and the patient will benefit more if one is able to apply a variety of options for each individualized defect. A different approach to full-thickness skin grafting is also briefly discussed as the authors propose its utility in lower third reconstruction. In general, the surgeon should approach each patient as a distinct individual with a unique defect and thus tailor each reconstruction to fit the patient's needs and expectations. Postoperative care, including dermabrasion, skin care, and counseling, cannot be understated.
- Published
- 2010
50. Office testing for dyslexia
- Author
-
John R. Griffin
- Subjects
Ophthalmology ,business.industry ,Dyslexia ,Medicine ,General Medicine ,business ,medicine.disease ,Clinical psychology - Published
- 1992
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