1. CREUTZFELDT-JAKOB DISEASE AFTER ADMINISTRATION OF HUMAN GROWTH HORMONE
- Author
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M. A. Preece, Roy O. Weller, John Powell-Jackson, Philip Kennedy, John Newsome-Davis, and E. M. Whitcombe
- Subjects
Pediatrics ,medicine.medical_specialty ,Pathology ,Time Factors ,medicine.medical_treatment ,Physiology ,Disease ,Creutzfeldt-Jakob Syndrome ,Craniopharyngioma ,mental disorders ,medicine ,Humans ,Chemotherapy ,Cerebellar ataxia ,business.industry ,Transmission (medicine) ,Human growth hormone ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,nervous system diseases ,Child, Preschool ,Growth Hormone ,Female ,Viral disease ,medicine.symptom ,Spongiform encephalopathy ,business ,Administration (government) - Abstract
A 2-year-old girl had a craniopharyngioma removed in 1964. She received human growth hormone (HGH) twice a week from July, 1972, until July, 1976. In March, 1984, a subacute dementing illness developed with neurological signs that included pronounced cerebellar ataxia. A clinical diagnosis of Creutzfeldt-Jakob disease (CJD) was made. The patient died in February, 1985. Necropsy revealed a spongiform encephalopathy compatible with the transmissible form of CJD. HGH administration may be implicated in the transmission of the disease in this case.
- Published
- 1985
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