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This study explores selective and consistent news avoidance in Aotearoa New Zealand. Existing research suggests that selective news avoidance rates are high in Aotearoa New Zealand (Myllylahti M, Treadwell G. 2023. Trust in News in Aotearoa New Zealand 2023. Journalism, Media and Democracy: AUT Research Centre for Journalism, Media & Democracy., Myllylahti M, Treadwell G. 2024. Trust in News in Aotearoa New Zealand 2023. Journalism, Media and Democracy: AUT Research Centre for Journalism, Media & Democracy.) but we know little about why this is and if reasons for avoiding the news differ depending on the type of news consumer. Drawing from a nationally representative survey of 1204 participants, this study explores the relationships between news avoidance, motivations and demographic factors. We confirm the high rates of selective news avoidance and report that Aotearoa New Zealand has high rates of consistent news avoiders. New Zealanders’ primary motivations to avoid the news are because of how the news negatively affects their well-being, or because they do not trust the news, or are turned off by the quality of news reporting. We also find that gender and political beliefs are associated with the frequency of and motivations for news avoidance. We discuss why New Zealand has high rates of selective and consistent news avoidance, as well as the implications, and furthermore why women, and people with very left-wing or very right-wing political beliefs may avoid the news more frequently than other groups.

Stories have been shown to be engaging and aid the comprehension and retention of information. However, the persuasive power of storytelling is well-recognized. Is this an inherent property? Can a narrative be constructed that helps people engage with information but does not persuade them? We presented participants (n = 1309) with information about a fictional new drug and asked them whether they would license it on the basis of this. All saw the same information, in either a bullet-pointed list or as a ‘process narrative’—a journalist’s ‘journey of discovery’, designed to avoid persuasive language. Participants rated the narrative format a little more engaging than the non-narrative (p = 0.033, d = 0.12) and remembered the information in it slightly better (p = 0.040, d = 0.11). They did not rate the narrative version as more persuasive, but those reading it were on average more opposed to licensing the drug than those reading the non-narrative (p < 0.001, d = 0.18). Based on participants’ responses to other questions, we speculate this may be owing to the increased salience of risks of the drug, arising from subtle differences in wording. Thus, while narratives may have useful properties, they must be carefully constructed to avoid unintentional effects.

Utilising the ABC Learning Design based on the ABC curriculum design method (Young & Perović 2016) and the Conversational Framework (Laurillard 2012), specifically the six learning types that underpin that model, eight Massive Open Online Courses (MOOCs) from Coursera or FutureLearn were examined. These MOOCs were selected because they represent a wide range of disciplines, assessment options, and course structures. This paper will demonstrate how the application of various learning types impacts how learners engage with the material, progress through the course, and how it influences their commitment to continue learning (Martin & Bolliger 2018). Additionally, results from this research provide evidence of how the frequency and sequencing of learning types create opportunities for learners to engage with content in a meaningful way. By synthesising the secondary data from pre-course surveys, exit surveys, end-of-course surveys, comment sections, and several other course metrics, including but not limited to the watch-through rates and technical feedback of over 400 videos, course completion, assessment completion, and learner satisfaction, seven key areas of impactful course design were identified and will be explored throughout this paper. These key areas will focus on the following elements of course design (1) quality and duration of videos, (2) balance and distribution of acquisition learning types (3) structure of discussions, (4) effective guidance for exploration activities, (5) balance of assessment and feedback opportunities, (6) utilisation of e-learning tools and plug-ins, and (7) successfully leveraging the synergies between the learning types in online course design. This empirical research will present evidence on how learning types can be successfully deployed in course design and course design sequencing.

Abstract Background To avoid the overuse of antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), acting via cyclooxygenase (COX) inhibition, have been used to reduce pain and as an alternative treatment for uncomplicated urinary tract infections (UTIs). However, clinical studies evaluating NSAIDs versus antibiotics have reported an increased risk of acute pyelonephritis. Therefore, we hypothesized that COX inhibition could compromise the innate immune response and contribute to complications in patients with uncomplicated UTI. Results We here demonstrate that in particular COX-2 inhibition led to decreased expression of the antimicrobial peptides psoriasin and human β-defensin-2 in human uroepithelial cells. Psoriasin expression was altered in neutrophils and macrophages. COX-2 inhibition also had impact on the inflammasome mediated IL-1β expression in response to uroepithelial E. coli infection. Further, COX-2 inhibition downregulated free radicals and the epithelial barrier protein claudin 1, favoring infectivity. In addition, conditioned media from COX-2 inhibited uroepithelial cells infected with E. coli failed to activate macrophages. Conclusions Taken together, our data suggests an adverse innate immune effect of COX-2 inhibition on uroepithelial cells during UTI.

Uncertainty around statistics is inevitable. However, communicators of uncertain statistics, particularly in high-stakes and potentially political circumstances, may be concerned that presenting uncertainties could undermine the perceived trustworthiness of the information or its source. In a large survey experiment (Study 1; N = 10 519), we report that communicating uncertainty around present COVID-19 statistics in the form of a numeric range (versus no uncertainty) may lead to slightly lower perceived trustworthiness of the number presented but has no impact on perceived trustworthiness of the source of the information. We also show that this minimal impact of numeric uncertainty on trustworthiness is also present when communicating future, projected COVID-19 statistics (Study 2; N = 2,309). Conversely, we find statements about the mere existence of uncertainty, without quantification, can reduce both perceived trustworthiness of the numbers and of their source. Our findings add to others suggesting that communicators can be transparent about statistical uncertainty without undermining their credibility as a source but should endeavour to provide a quantification, such as a numeric range, where possible.

Nonprofits often function as a key part of the social safety net by providing services to vulnerable populations and strengthening communities. Despite their essential nature, research on organizational resilience (OR) among nonprofits tends to focus on surviving financial distress, while other organizational aspects of resilience are less emphasized. Finding few nonprofit OR models that address our research context, we adapt and extend a model of OR from the for-profit sector. Our model adaptation includes technical, social and financial resources and expands each category to cover unique aspects of nonprofits that the for-profit OR model does not contain. We also borrow concepts from social-ecological resilience (SER) to enhance our nonprofit-adapted OR model, which we test using a case study of intimate partner abuse (IPA) agencies. We examined eight IPA nonprofits in a Midwestern state during the COVID–19 pandemic, interviewing both managers and frontline staff. We hope our adapted model can be used by researchers and practitioners to better understand and evaluate OR not only in IPA agencies, but all nonprofits.

Abstract Urinary tract infection frequently caused by E. coli is one of the most common bacterial infections. Increasing antibiotic resistance jeopardizes successful treatment and alternative treatment strategies are therefore mandatory. Metformin, an oral antidiabetic drug, has been shown to activate macrophages in the protection against certain infecting microorganisms. Since epithelial cells often form the first line of defense, we here investigated the effect on uroepithelial cells during E. coli infection. Metformin upregulated the human antimicrobial peptides cathelicidin LL-37 and RNase7 via modulation of the TRPA1 channel and AMPK pathway. Interestingly, metformin stimulation enriched both LL-37 and TRPA1 in lysosomes. In addition, metformin specifically increased nitric oxide and mitochondrial, but not cytosolic ROS. Moreover, metformin also triggered mRNA expression of the proinflammatory cytokines IL1B, CXCL8 and growth factor GDF15 in human uroepithelial cells. The GDF15 peptide stimulated macrophages increased LL-37 expression, with increased bacterial killing. In conclusion, metformin stimulation strengthened the innate immunity of uroepithelial cells inducing enhanced extracellular and intracellular bacterial killing suggesting a favorable role of metformin in the host defense.

A notable challenge of the SARS-CoV-2 pandemic has been public scepticism over the severity of the disease, or even its existence. Such scepticism is politically skewed in the USA, with conservatives more likely to downplay or deny the risks of the virus. However, the hospitalization of President Trump with COVID-19 in October 2020 served as a high-profile exemplar of the reality and risks of the virus, and as such may have influenced opinions, particularly for US conservatives. We investigate whether President Trump testing positive was associated with changes in public attitudes towards the virus. In two studies, we surveyed independent representative US samples before and after the announcement of Trump's illness. In Study 1, measuring risk perceptions of the virus, we find that participants surveyed before and after the announcement did not differ in their risk perception regardless of political orientation. In Study 2, measuring belief that the virus is a hoax, we find that among those on the far right of the political spectrum, hoax belief was lower for those surveyed after the announcement, suggesting that Trump's hospitalization may have affected the beliefs of those most receptive to the President's earlier suggestions that the virus might be a hoax.

Abstract Patients undergoing cochlear implant after prior radical mastoidectomy are at increased risk of device infection requiring device explant. Various techniques including two‐stage operations have been used. We report the novel technique with use of a vascularized fascia lata free flap for a patient undergoing cochlear implantation with radical mastoidectomy.

As increasing amounts of data accumulate on the effects of the novel coronavirus SARS-CoV-2 and the risk factors that lead to poor outcomes, it is possible to produce personalized estimates of the risks faced by groups of people with different characteristics. The challenge of how to communicate these then becomes apparent. Based on empirical work (total n = 5520, UK) supported by in-person interviews with the public and physicians, we make recommendations on the presentation of such information. These include: using predominantly percentages when communicating the absolute risk, but also providing, for balance, a format which conveys a contrasting (higher) perception of risk (expected frequency out of 10 000); using a visual linear scale cut at an appropriate point to illustrate the maximum risk, explained through an illustrative ‘persona’ who might face that highest level of risk; and providing context to the absolute risk through presenting a range of other ‘personas’ illustrating people who would face risks of a wide range of different levels. These ‘personas’ should have their major risk factors (age, existing health conditions) described. By contrast, giving people absolute likelihoods of other risks they face in an attempt to add context was considered less helpful. We note that observed effect sizes generally were small. However, even small effects are meaningful and relevant when scaled up to population levels.

Misinformation about COVID-19 is a major threat to public health. Using five national samples from the UK (n = 1050 and n = 1150), Ireland (n = 700), the USA (n = 700), Spain (n = 700) and Mexico (n = 700), we examine predictors of belief in the most common statements about the virus that contain misinformation. We also investigate the prevalence of belief in COVID-19 misinformation across different countries and the role of belief in such misinformation in predicting relevant health behaviours. We find that while public belief in misinformation about COVID-19 is not particularly common, a substantial proportion views this type of misinformation as highly reliable in each country surveyed. In addition, a small group of participants find common factual information about the virus highly unreliable. We also find that increased susceptibility to misinformation negatively affects people's self-reported compliance with public health guidance about COVID-19, as well as people's willingness to get vaccinated against the virus and to recommend the vaccine to vulnerable friends and family. Across all countries surveyed, we find that higher trust in scientists and having higher numeracy skills were associated with lower susceptibility to coronavirus-related misinformation. Taken together, these results demonstrate a clear link between susceptibility to misinformation and both vaccine hesitancy and a reduced likelihood to comply with health guidance measures, and suggest that interventions which aim to improve critical thinking and trust in science may be a promising avenue for future research.

A Massive Open Online Course (MOOC) was developed to help promote awareness of, and support student transitions into, a fully online distance, credit-bearing postgraduate certificate (PGCert). A qualitative study using semi-structured interviews was undertaken with participants on the PGCert to investigate learner experiences of both the MOOC and PGCert, and to establish the extent to which the MOOC supported learners’ transitions into the PGCert in terms of their (1) foundation knowledge, (2) study skills, (3) digital literacies, (4) readiness for self-directed learning, and to determine whether additional efforts could have been directed to more effectively support student transitions. Findings revealed that the MOOC informed participants’ decision to undertake the fully online PGCert, and that this was due to the effective learning design and a strong teacher presence throughout. The participants already possessed some background knowledge and a number of essential learning skills (though not uniformly), questioning assumptions around MOOCs as an aid to widening participation in higher education; however, the MOOC helped to enhance and unify these. Not surprisingly, there were some challenges encountered on entering online postgraduate study that the MOOC design could not anticipate or solve; therefore, we recommend that online learners are appropriately supported throughout their studies. This work has implications in terms of how MOOCs may help facilitate student transitions into other fully online, credit-bearing programmes of study.

Introduction Arteriovenous fistulas (AVFs) are considered the best and safest modality for providing haemodialysis in patients with end-stage renal disease. Only 20% of UK centres achieve the recommended 80% target for achieving dialysis of the prevalent dialysis population via permanent access (as opposed to a central venous catheter). This is partly due to the relatively poor maturation rate of newly created fistulas, with as many as 50% of fistulas failing to mature.The Surveillance Of arterioveNous fistulAe using ultRasound study will examine whether a protocolised programme of Doppler ultrasound (US) surveillance can identify, early after creation, potentially correctable problems in those AVFs that subsequently fail to mature.Methods and analysis This is a multicentre observational study that will assess newly created AVFs by Doppler US performed at 2, 4, 6 and 10 weeks after creation. The primary outcome measure will be primary fistula patency at week 10. Secondary outcome measures include: successful use of the fistula; clinical suitability for dialysis; creation of new fistula or radiological salvage; fistula thrombosis; secondary fistula patency rate and patient acceptability.Ethics and dissemination The study has been approved by the Cambridgeshire and Hertfordshire Research Ethics Committee and by the Health Research Authority (REC 18/EE/0234). The results generated from this work will be published as open access, within 3 years of trial commencement. We will also present our findings at key national/international renal meetings, as well as support volunteers at renal patient groups to disseminate the trial outcome.Trial registration number ISRCTN36033877

Antibiotic resistance in fungal isolates is increasing on a global scale. Despite knowledge that pig farmers are occupationally exposed to infectious species of fungi, such as Aspergillus spp., little is known regarding their potential exposure to antifungal-resistant Aspergillus spp. The aim of this study is to obtain knowledge regarding the antifungal resistance profiles of isolates of Aspergillus species taken from different source materials—including airborne dust, surface dust, faeces, and straw—within a pig farm. The EUCAST broth microdilution method was used for testing antifungal resistance from 43 isolates of Aspergillus sampled in 3 periods inside a Danish pig farm. Seven species of Aspergillus were obtained, including A. candidus (n = 5), A. fumigatus (n = 5), A. glaucus (n = 13), A. nidulans (n = 2), A. niger (n = 15), A. terreus (n = 1), and A. versicolor (n = 2). Overall, 27.9% of the Aspergillus isolates displayed resistance against at least one antifungal, and 11.6% of Aspergillus isolates displayed resistance against multiple antifungals. The most abundant group exhibiting antifungal resistance was affiliated with the species A. niger, with isolates exhibiting resistance to itraconazole, voriconazole, and caspofungin. One isolate of A. glaucus and two isolates of A. versicolor were resistant to amphotericin B (MIC ≥ 2 mg/L amphotericin B). Antibiotic-resistant fungi were found on all three sampling days.

Fungal species composition and site of deposition within the airways affects whether diseases develop and where they may arise. The aim of this study is to obtain knowledge regarding the potential deposition of airborne culturable, viable, and non-viable fungi in the airways of pig farm workers, and how this composition changes over multiple sampling days. Airborne fungi were sampled using impactors and subsequently analyzed using amplicon sequencing and matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) fingerprinting. The geometric mean aerodynamic diameter (Dg) of airborne particles with culturable airborne fungi were not affected by sampling days and ranged in size between 3.7 and 4.6 µm. Amplicon sequencing of the internal transcribed spacer region of the rRNA gene operon, in combination with DNA interchelating agents, revealed a large presence of non-viable fungi, but several pathogenic and toxic fungal species were detected in the viable portion. The diversity was found to be significantly associated with the sampling day but did not change significantly over multiple sampling rounds during the same day. The non-viable fraction contained genera typically associated with the pig gastrointestinal tract, such as Kazachstania and Vishniacozyma. In conclusion, the Dg of culturable fungi was between 3.7 and 4.6 µm, and the Dg of the viable and total fungi was 1.5 and 2.1 µm, respectively. The species composition changed over the multiple sampling days.

This article examines violent protest in art museums. There is a long history of art museums being used as sites of protest. As spaces full of meaning, they represent ideal locations for people to try to shape the present and the future. From peaceful demonstrations to terrorist attacks, the current risks of protest to art museums is high. Motivated by ideological, political and social reasons, these protests include those that specifically target art objects within the art museums, as well as others that use the sites as stages on which to protest. This article is based predominantly on secondary sources; however, it also uses empirical research data collected by the author during observation research at art museums in London in March 2017 and July 2017. The article begins by considering why art museums attract so many protests. It argues that as ‘sites of persuasion’, art museums can be battlegrounds on which people look to shape how society is constructed and perceived. It then examines contemporary and historical case studies in Brazil and the UK to help our understanding of violent protests and the challenges they pose to art museums. Following this, the article proposes that as art museums are important sites of persuasion, there must be more awareness of the threats they face from violent protests in order to shape crime prevention approaches. The article finishes by arguing that although protests can be highly problematic for people involved with art museums, the ongoing appeal of these spaces as sites of protest shows the significance of art museums as important locations of cultural meaning.

Watershed development is an important component of rural development and natural resource management strategies in many countries. A watershed is a special kind of common pool resource: an area defined by hydrological linkages where optimal management requires coordinated use of natural resources by all users. Management is difficult because natural resources comprising the watershed system have multiple, conflicting uses, so any given management approach will spread benefits and costs unevenly among users. To address these challenges, watershed approaches have evolved from more technocratic to a greater focus on social organization and participation. However, the latter cannot necessarily be widely replicated. In addition, participatory approaches have worked better at a small scale, but hydrological relationships cover a larger scale and some projects have faced tradeoffs in choosing between the two. Optimal approaches for future efforts are not clear, and theories from common property research do not support the idea that complex watershed management can succeed everywhere. Solutions may include simplifying watershed projects, pursuing watershed projects where conditions are favorable, and making other investments elsewhere, including building the organizational capacity that can facilitate watershed management.

Generalised post-operative cerebral vasospasm is a major factor in delineating poor operative results following direct ruptured intracranial aneurysms. Continuous monitoring of intracranial pressure seems to be particularly helpful on such occasions, and intracranial compliance determination as well. High intracranial compliance values suggest that even small intracranial volume increases may induce rapid intracranial pressure increase and situations likely to produce neurological deterioration.