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1. Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

2. Calcineurin Inhibitor in NEuRoloGically deceased donors to decrease kidney delayed graft function study: study protocol of the CINERGY Pilot randomised controlled trial

3. MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer

4. Impact of a varied set of stimuli on a suite of immunological parameters within peripheral blood mononuclear cells: toward a non-animal approach for assessing immune modulation by materials intended for human use

5. Ceragenin-coated endotracheal tubes for the reduction of ventilator-associated pneumonia: a prospective, longitudinal, cross-over, interrupted time, implementation study protocol (CEASE VAP study)

6. A cell-based, SARS-CoV-2 spike protein interaction assay to inform the neutralising capacity of recombinant and patient sera antibodies

7. Further Validation of the Crohn’s and Ulcerative Colitis Questionnaire-32 (CUCQ-32) to Measure the Quality of Life in Patients Treated with Biologics Therapy

8. Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures

10. Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol

11. CRISPR/Cas9-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver Disease

12. Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation

13. Regulatory Requirements for the Development of Second-Entry Semisolid Topical Products in the European Union

14. Identification of Inhibitors of Tubulin Polymerization Using a CRISPR-Edited Cell Line with Endogenous Fluorescent Tagging of β-Tubulin and Histone H1

15. Identifying neurocognitive outcomes and cerebral oxygenation in critically ill adults on acute kidney replacement therapy in the intensive care unit: the INCOGNITO-AKI study protocol

16. Cerebral Perfusion in Hemodialysis Patients: A Feasibility Study

17. Development of a 96-Well Electrophilic Allergen Screening Assay for Skin Sensitization Using a Measurement Science Approach

18. Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation

19. I N D E X

21. NOTES

26. INTRODUCTION

30. CONTENTS

31. PREFACE

34. Liquid Water Transport in Porous Metal Foam Flow-Field Fuel Cells: A Two-Phase Numerical Modelling and Ex-Situ Experimental Study

35. A new approach of modified submerged patch clamp recording reveals interneuronal dynamics during epileptiform oscillations

36. C. Richard Conti and Chinese cardiology 1989–2022

37. Women’s education reduces risk of Gender-Based Violence: evidence from 29 countries

38. SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro.

41. Non-invasive mapping of systemic neutrophil dynamics upon cardiovascular injury

42. Shared decision‐making for older adults with cardiovascular disease

43. Community Science, Storytelling, or Inquiry-Based Learning? Evaluating Three Technology-Enhanced Pedagogical Approaches in an Online Botany Course

46. Ceragenin-coated endotracheal tubes for the reduction of ventilator-associated pneumonia: a prospective, longitudinal, cross-over, interrupted time, implementation study protocol (CEASE VAP study)

47. Personal financial planning advice : barriers to access

49. Variability in deceased donor care in Canada: a report of the Canada-DONATE cohort study

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