Search

Abstract Research and innovation (R&I) institutions must commercialize their innovations to remain competitive in a knowledge-based economy. While R&I institutions in Uganda have the potential to drive socioeconomic development, a clear understanding of the commercialization pathway is lacking. This study aims to bridge this gap by analyzing the systemic, infrastructural, and financial factors that drive and hinder the commercialization of innovations at R&I institutions in Uganda. This study offers the first comprehensive examination of the systemic, infrastructural, and financial dimensions influencing innovation commercialization within Uganda's R&I ecosystem, presenting new empirical evidence on the prioritized barriers and drivers as perceived by key stakeholders. Employing a mixed-method approach, this study uniquely combines quantitative surveys with qualitative case studies and key informant interviews, enabling a nuanced understanding of the multifaceted drivers of and barriers to innovation commercialization in Uganda. The study employed the Delphi technique to identify consensus among key informants. The findings highlight the urgent barriers to address, including fragmented R&I ecosystems, inadequate support infrastructure, such as technology transfer offices, and significant gaps in innovation financing. These issues underscore the urgent need for targeted policy interventions. Based on our findings, we recommend the establishment of a national innovation fund, enhancement of public private partnerships for R&D infrastructure development, and formulation of a cohesive national policy framework to streamline commercialization processes at R&I institutions. This study provides policymakers with a data-driven foundation to craft targeted interventions aimed at removing the identified barriers, thereby catalyzing the commercialization of innovations in Uganda's R&I institutions.

Abstract Background Biofilms and oxidative stress retard wound healing. The resistance of biofilms to antibiotics has led to a search for alternative approaches in biofilm elimination. Antioxidants work synergistically with antibacterial agents against biofilms. Hence recent research has suggested plants as candidates in the development of new alternatives in biofilm treatments and as antioxidants due to the presence of phytocompounds which are responsible for their bioactivities. Hoslundia opposita Vahl is one of the plants used by traditional healers to treat wounds and other infections, this makes it a potential candidate for drug discovery hence, in this study, we investigate the antibiofilm and antioxidant activity of methanolic extract of hoslundia opposita Vahl from Uganda. We also identify phytochemicals responsible for its bioactivity. Method the plant was extracted by maceration using methanol, and the extract was investigated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) assay. The antibiofilm activity using microtiter plate assay (MTP) assay where the Minimum biofilm inhibitory concentration required to inhibit 50% or 90% of the biofilm (MBIC50 and MBIC90) and Minimum biofilm eradication concentration required to remove 50% or 90% of the biofilm (MBEC50 and MBEC90) were measured. It was further analysed for its phytochemical composition using quantitative screening, as well as Gas chromatography-mass spectrometry (GC-MS) and Liquid chromatography mass-spectrometry (LC-MS). Results H. Opposita Vahl extract showed good antioxidant activity with of 249.6 mg/mL. It inhibited the growth of P. aeruginosa and S. aureus biofilms with MBIC50 of 28.37 mg/mL and 10 mg/mL, respectively. It showed the ability to eradicate P. aeruginosa and S. aureus biofilms with MBEC50 of 23.85 and 39.01 mg/mL respectively. Phytochemical analysis revealed the presence of alkaloids, tannins, flavonoids, and phenols. GC-MS analysis revealed 122 compounds in the extract of which, 23 have evidence of antioxidant or antibiofilm activity in literature. The most abundant compounds were; 1,4- Citric acid, Tetracontane-1,40-diol (43.43.3%, 1, Olean-12-en-28-oic acid, 3-hydroxy-, methyl ester, (3.beta) (15.36%) 9-Octadecenamide (12.50%), Squalene (11.85%) Palmitic Acid 4TMS (11.28%), and alpha Amyrin (11.27%). The LC-MS identified 115 and 57 compounds in multiple reaction mode (MRM) and scan modes respectively. Conclusion H. opposita Vahl showed antibiofilm and antioxidant activity due to bioactive compounds identified, hence the study justifies its use for wound healing. It can be utilised in further development of new drugs as antibiofilm and antioxidants.

This paper assessed the technical and economic viability of biodiesel production from Second-generation feedstocks native to East Africa, which included Castor, Croton, and Jatropha. Their oils were converted to biodiesel by transesterification and characterizations of B100 and B10 done following ASTM D6751. ASPEN Plus V11 was used in process simulation and profitability analysis. Oil yields obtained ranged from 29.5% to 35.6%. B100 and B10 properties conformed to ASTM D6751. The negative Net Present Values obtained render B100 and B10 production uneconomical unless incentivized. Sensitivity analyses showed that NPV varied with feedstock cost and biodiesel selling prices. This assessment established that though a B10 policy based on second-generation feedstocks is technically viable, interventions are needed to make it profitable in Uganda.

The application of biogas as a renewable energy source continues to face competition from conventional energy sources, which are readily available and seemingly cheap. In addition, productive biogas system deployments in Uganda are currently facing challenges related to sustainability of biogas production, which has led to massive dis-adoption in recent years. These systems have failed to utilize alternatives during scarcity of primary feedstock due to lack technical data for energy recovery, which could be linked to insufficient R&D in the biogas sector. Relatedly, global scientific research has placed focus mostly on methane yield improvements through optimization of anaerobic digestion kinetics on lab-scale, with little focus on the enabling environment for these kinetics to thrive in continuously operated systems.This study therefore aimed to develop an integrated energy recovery system that enables alteration of feedstock and control of digester operating parameters for sustainable biogas production in continuously fed digesters. An array of system components was developed and integrated into a state-of-art energy recovery system, which was prototyped and deployed in real working environment for pilot studies. The system was configured to measure the moisture content of the feedstock and then determine and display to the operator the amount of water to be added to optimize the quality of the substrate. The system also monitors the digester operating parameters and prompts corrective action to prevent possible inhibition of biogas production process. Results show that the system is about 33% more efficient than the conventional one, allows alteration of feedstocks, and can be deployed to replace conventional energy usage for productive applications. For instance, a poultry farm with 10,000 commercial layers may have its energy needs be met 100% by the proposed system with a pay-back period of 4.5 years for deep liter system and 3.7 years for battery cage system.

With a vibrant economic development, Greater Kampala Metropolitan Area (GKMA) would need to boast low-carbon electricity generation, reduce carbon emissions, and re-structure transportation, yet having no energy management plan. The main objective of this study is to develop a comprehensive framework for analyzing energy impacts and macroeconomic effects of low-carbon scenarios and to identify a sustainable pathway towards 2050 for GKMA. The study uses TIMES/CGE hybrid framework to address the knowledge gap in 4 scenarios. Business as usual is the reference case with Kabejja (20% CO2 abatement), Carbon-Tax (100$/ton), and Lutta (95% CO2 abatement) as alternative scenarios. The analysis shows an increase in consumption from 139.6PJ to 469.35PJ and carbon emissions from 4.6mtns to 7mtns in the reference case. However, consumption and carbon emissions decrease in all the alternative scenarios compared to the reference case. The GDP and equivalent variation (EV) in household welfare increase in all alternative scenarios compared to the reference case. Lutta promises a 60.6% reduction in the carbon emissions intensity of GDP to be realistic. Sustainability is achievable when low-carbon electricity becomes the major contributor to the demand by fuel type, optimization of the total primary energy supply, and construction of an electrified Kampala metro. Transportation, Industrial and Residential sectors are the greatest emitters of CO2 by sector in all scenarios and thus need policy interventions to realize deep CO2 emissions reductions. The study recommends that Lutta guarantee a sustainable low-carbon footprint for GKMA.

Objective: This study aimed to investigate relationship between blood production factors and transfusion sustainability. Methods: A self-administered questionnaire was employed to gather data from randomly selected participants in blood banks. Partial least squares structural equation modeling tool was used in the analysis. Results: The findings indicated that blood production factors have a considerable and positive influence on the transfusion sustainability of blood banks in Uganda. Conclusion: The enhancement of transfusion sustainability is supported by blood production factors. Consequently, it is advisable to prioritize blood production to ensure adequacy and timely supply of blood products.

Abstract Background Wounds inflict pain and affect human health causing high expenditure on treatment and management. Herbal crude extracts are used in traditional medicine as a treatment for wounds and other illnesses. However, the progress in the use of plants has been deterred due to their poor solubility and poor bioavailability requiring administration at high doses. It has been established that nanoencapsulation of herbal products in nanocarriers (size 1 nm to 100 nm) such as nanofibers, nanoparticles, nanospheres, and nanoliposomes greatly improves their efficacy. Due to their small and large surface area, nanocarriers are more biologically active, improve bioavailability, protect the drug from deterioration, and release it to the targeted site in a sustainable manner. Aim The review aims to collate and appraise evidence on the efficacy of nano encapsulated herbal extracts in the treatment of induced wounds in animal models. Methods The review will be protocol-driven and conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Protocols (PRISMA-P) and protocol guidelines for systematic review and meta-analysis for animal intervention studies. The final review will be conducted and reported with reference to PRISMA 2020 statement. Studies will be searched in Pub Med, ProQuest, Web of Science, Medline Ovid, EMBASE, and Google Scholar. The PRISMA flow criteria will be followed in screening the articles for inclusion. Data extraction form will be designed in Excel spreadsheet 2013 and data extracted based on the primary and secondary outcomes. Risk of bias assessment will be done using SYRCLE’s risk of bias tool for animal studies. Data analysis will be done using narrative and quantitative synthesis. Expected results We hope to make meaningful comparisons between the effectiveness of the herb-loaded nanomaterials and other interventions (controls) in the selected studies, based on the primary and secondary outcome measures. We expect that these findings to inform clinical practice on whether preclinical studies show enough quality evidence on the efficacy and safety of herbal-loaded nanomaterials that can be translated into clinical trials and further research. Systemic review registration PROSPERO 330330. The protocol was submitted on the 11th of May 2022.

Previous studies in Uganda have primarily explored kaolin's applications in composites, pottery, bricks, and insulation, neglecting its potential for coatings and paints, which is crucial for industrialization and saving foreign exchange. This study investigates the transformation of kaolin through various treatments and analyzes their impacts on its physical and chemical properties for potential use in coating applications. Thermal analysis, X-ray Fluorescence Spectroscopy (XRF), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), and transmission electron microscopy (TEM) techniques were employed to assess these alterations. The results show that thermal treatment of kaolin at 45.9 °C had minimal impact on mass loss, while the crystallinity of kaolinite was found to be lost around 600 °C, resulting in structural changes. XRF result demonstrates variations in SiO2 and Al2O3 composition, with low TiO2 content desirable for paint and coating applications. XRD results showed well-defined diffractions associated with kaolinite in all treated and untreated kaolin samples. The presence of K-feldspar and quartz are also identified. However, the thermal treatment at 800 °C transforms kaolinite into metakaolin, essential for enhancing coating properties. SEM-EDS results indicate increased porosity and reduced impurities in the thermal-treated sample, which might enhance the whiteness and suitability of pigment and binder dispersion in coatings. TEM images confirmed the hexagonal nature of kaolinite platelets and demonstrated the amorphous nature of kaolin nanoparticles with ammonium molybdate treatment, which led to the delamination and exfoliation of kaolinite layers, improving dispersibility. Kaolin thermally treated exhibited good crystallinity, solid growth, cubic morphology, and uniform size distribution. These findings suggest that tailored treatments can optimize kaolin's properties, making it a promising additive for high-performance coatings.

BackgroundLeukemia encompasses various subtypes, each with unique characteristics and treatment approaches. The challenge lies in developing targeted therapies that can effectively address the specific genetic mutations or abnormalities associated with each subtype. Some leukemia cases may become resistant to existing treatments over time making them less susceptible to chemotherapy or other standard therapies.ObjectiveDeveloping new treatment strategies to overcome resistance is an ongoing challenge particularly in Low and Middle Income Countries (LMICs). Computational studies using COMSOL software could provide an economical, fast and resourceful approach to the treatment of complicated cancers like leukemia.MethodsUsing COMSOL Multiphysics software, a continuous flow microfluidic device capable of delivering anti-leukemia drugs to early-stage leukemia cells has been computationally modeled using dielectrophoresis (DEP).ResultsThe cell size difference enabled the micro-particle drug attachment to the leukemia cells using hydrodynamic focusing from the dielectrophoretic force. This point of care application produced a low voltage from numerically calculated electrical field and flow speed simulations.ConclusionTherefore, such a dielectrophoretic low voltage application model can be used as a computational treatment reference for early-stage leukemia cells with an approximate size of 5 μm.

Global energy demand continues to increase owing to advancements in key growth sectors of Economies. Transportation-related emissions resulting from petroleum use account for 23% of total energy-related CO2 emissions. Biofuels including biodiesel are renewable substitutes for transportation fuels that have attracted global interest. This paper reviewed existing literature on technological, economic, and life cycle environmental aspects vital for assessment of the viability of production of second-generation biodiesel including the B10 blend advocated for Uganda. The quantity of biodiesel required to fulfil a B10 blend for Uganda’s downstream petroleum sector is one hundred million litres per annum. To meet this demand, 50,000 ha of land is required for cultivation of biodiesel feedstocks against the available 6,900,000 ha. Jatropha, castor, and croton, offer agronomical advantages. Biodiesel produced from these feedstocks through transesterification, should conform to ASTM D6751/EN14214 standards. Physicochemical, economic, and environmental assessments are vital to confirm its techno-economic viability.

Abstract Objective Green synthesized iron(III) oxide (Fe3O4) nanoparticles are gaining appeal in targeted drug delivery systems because of their low cost, fast processing and nontoxicity. However, there is no known research work undertaken in the production of green synthesized nano-particles from the Ugandan grown Moringa Oleifera (MO). This study aims at exploring and developing an optimized protocol aimed at producing such nanoparticles from the Ugandan grown Moringa. Results While reducing ferric chloride solution with Moringa oleifera leaves, Iron oxide nanoparticles (Fe3O4-NPs) were synthesized through an economical and completely green biosynthetic method. The structural properties of these Fe3O4-NPs were investigated by Ultra Violet–visible (UV–Vis) spectrophotometry, X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX) and scanning electron microscopy (SEM). These nanoparticles exhibited UV–visible absorption peaks at 225 nm (nm) for the sixth dilution and 228 nm for the fifth dilution which indicated that the nanoparticles were photosensitive and the SEM study confirmed the spherical nature of these nanoparticles. The total synthesis time was approximately 5 h after drying the moringa leaves, and the average particle size was approximately 16 nm. Such synthesized nanoparticles can potentially be useful for drug delivery, especially in Low and Middle Income Countries (LMICs).

The solar salt pans at Lake Katwe are set up haphazardly without any scientific guidelines which compromises the annual throughput from the solar salt works. To improve on the design of the salt pans, the heat transfer dynamics of the salt pan have been numerically and experimentally studied in this study. A representative salt pan located at the shores of the lake Katwe with a surface area of 62 m2 and a depth of 0.2 m was used in this study. The numerical model was implemented in the OpenFOAM software where a 3D heat transfer salt pan model was studied using the Finite Volume Method under Lake Katwe climatic conditions. The model was governed by continuity, salt concentration, momentum, energy equations and the Boussinesq approximation. A field experiment that determined the temperature variation with depth was carried out. The correctness of the model results was verified against experimental data. The numerical simulation model revealed a salt pan brine temperature increase with time and the salt concentration significantly remained constant with time. The salt pan brine temperature increased from 303 K to 319.5 K after 5 h of the simulation time. The model and the experimental salt concentration and temperature profiles were found to be in a good agreement. The sensitivity analysis on the effect of the salt pan depth on brine temperature was studied. It was revealed that the shallower the salt pan, the higher the rate of heat gain. This study revealed that an optimum salt pan depth to yield a higher salt quantity under Lake Katwe climatic conditions was at 0.1 m.

Introduction: This study investigates the relationship between master production scheduling and blood transfusion sustainability of blood banks in Uganda. The elements of master production scheduling included supply, demand and perishability. Objective: The purpose of the study was to investigate relationship of master production scheduling on blood transfusion sustainability of blood banks in Uganda with three objectives. First, to determine the relationship between supply element and blood transfusion sustainability. Second, to determine the relationship of demand element and blood transfusion sustainability. Finally to determine the relationship of perishability element and blood transfusion sustainability. Methods: This paper presents an alternative methodology to investigate the relationship of master production scheduling on blood transfusion sustainability of blood banks in Uganda. Data was collected using a self-administered questionnaire survey from a random sample of 213 respondents. Statistical Package for Social Sciences (SPSS version 20) and analysis of moment of structures (AMOS version 23) were used for data analysis. Results: The results of the study revealed that there is a significant positive relationship between master production scheduling and blood transfusion sustainability of blood banks in Uganda with the prediction rate of 0.173 with 95% confidence level. Supply and demand elements are found to be significant predictors of blood transfusion sustainability. Blood transfusion sustainability did not appear to be significantly affected by perishability element. Conclusion: Master production scheduling has a positive significant relationship with blood transfusion sustainability in Uganda, leading to timely delivery of blood products to healthcare facilities. Master production scheduling is recommended in order to save lives of patients in need of blood.

ABSTRACTPoly(ethylene terephthalate) (PET) has a wide range of applications that generate a lot of waste globally; thus, upcycling PET is important because it offers several industrial and economic advantages. This study describes a sustainable, emissions-free process for converting PET plastics into carbon nanomaterials (CNMs) named PT-nano powder. The thermal-hydrothermal method has employed the production of PT-nano powder above the glass transition temperature (Tg) of PET plastics. Under optimal conditions, PET plastics were efficiently converted into PT-nano powder with 86.6% crystallinity and an average particle size of 6.5 nm. The PT-nano powder was characterized for physical and chemical properties using different techniques, including UV-Vis, FTIR, Raman spectroscopy, XRD, FESEM, TEM, and proton NMR analysis. The characterization confirms the complete conversion of PET to solid fractions of carbon nanomaterial. The PT-nano powder was tested in supercapacitor performance application with electrochemical characterization. The symmetric fabrication showed a specific capacitance of 250.8 F/g, energy density of 34.83Wh/kg, and power density of 999.9W/kg with a current density of 0.5A/g. The device fabrication exhibited high cycle stability and high capacitance retention of 96.8% with a current density of 1.5A/g after 10000 cycles.

Virtual experimentation is a widely used approach for predicting systems behaviour especially in situations where resources for physical experiments are very limited. For example, targeted treatment inside the human body is particularly challenging, and as such, modeling and simulation is utilised to aid planning before a specific treatment is administered. In such approaches, precise treatment, as it is the case in radiotherapy, is used to administer a maximum dose to the infected regions while minimizing the effect on normal tissue. Complicated cancers such as leukemia present even greater challenges due to their presentation in liquid form and not being localised in one area. As such, science has led to the development of targeted drug delivery, where the infected cells can be specifically targeted anywhere in the body. Despite the great prospects and advances of these modeling and simulation tools in the design and delivery of targeted drugs, their use by Low and Middle Income Countries (LMICs) researchers and clinicians is still very limited. This paper therefore reviews the modeling and simulation approaches for leukemia treatment using nanoparticles as an example for virtual experimentation. A systematic review from various databases was carried out for studies that involved cancer treatment approaches through modeling and simulation with emphasis to data collected from LMICs. Results indicated that whereas there is an increasing trend in the use of modeling and simulation approaches, their uptake in LMICs is still limited. According to the review data collected, there is a clear need to employ these tools as key approaches for the planning of targeted drug treatment approaches.

Greater Kampala Metropolitan Area (GKMA) is Uganda's capital facing increasing pressures to raise electricity generation and also mitigate CO2 emissions. A low-carbon electrification of the GKMA energy policy is proposed for sustainability. But the macroeconomic effects of this policy are unknown. The study uses a multi-sector, single region, static GKMA-CGE model to address the knowledge gap in 4 scenarios. BAU is the baseline against which comparisons with Kabejja (20% CO2 abatement); Carbon-Tax ($100/ton) and Lutta scenarios (95% CO2 abatement) are made. The results indicate GDP increased by Kabejja:0.7%; Carbon-Tax:1.3%; Lutta:1.56% with respect to BAU. Equivalent variation also increased compared to BAU. Energy & CO2 intensities of GDP decreased in all scenarios. The study recommends Lutta for a sustainable 2050.

Abstract Of recent, immense attention has been given to chitosan in the biomedical field due to its valuable biochemical and physiological properties. Traditionally, the chief source of chitosan is chitin from crab and shrimp shells. Chitin is also an important component of fish scales, insects and fungal cell walls. Thus, the aim of this study was to isolate and characterize chitosan from locally available material for potential use in the biomedical field. Chitosan ash and nitrogen contents ranged from 1.55 to 3.5% and 6.6 to 7.0% respectively. Molecular weight varied from 291 to 348KDa. FTIR spectra revealed high degree of similarity between locally isolated chitosan and commercial chitosan with DD ranging from 77.8 to 79.1%. XRD patterns exhibited peaks at 2θ values of 19.5° for both mushroom and banana weevil chitosan while Nile perch scales chitosan registered 3 peaks at 2θ angles of 12.3°, 20.1° and 21.3° comparable to the established commercial chitosan XRD pattern. Locally isolated chitosan exhibited antimicrobial activity at a very high concentration. Ash content, moisture content, DD, FTIR spectra and XRD patterns revealed that chitosan isolated from locally available materials has physiochemical properties comparable to conventional chitosan and therefore it can be used in the biomedical field.

The greatest challenge of the current generation and generations to come is antimicrobial resistance, as different pathogenic bacteria have continuously evolved to become resistant to even the most recently synthesized antibiotics such as carbapenems. Resistance to carbapenems limits the therapeutic options of MDR infections as they are the only safe and effective drugs recommended to treat such infections. This scenario has complicated treatment outcomes, even to the commonest bacterial infections. Repeated attempts to develop other approaches have been made. The most promising novel therapeutic option is the use of nanomaterials as antimicrobial agents. Thus, this study examined the efficacy of Camellia sinensis extract (CSE) and Prunus africana bark extract (PAE) green synthesized Copper oxide nanoparticles (CuONPs) against carbapenem-resistant bacteria. Furthermore, the photocatalytic and antioxidant activities of CuONPs were evaluated to determine the potential of using them in a wide range of applications. CuONPs were biosynthesized by CSE and PAE. UV vis spectroscopy, X-ray Diffraction (XRD), Dynamic light scattering (DLS), Fourier Transform Infrared spectroscopy (FTIR), and Scanning Electron Microscopy (SEM) were used to characterize the nanoparticles. CuONPs susceptibility tests were carried out by the agar well diffusion method. The photocatalytic and antioxidant activities of the CuONPs were determined by the methylene blue and DPPH free radical scavenging assays, respectively. UV vis absorbance spectra registered surface plasmon resonance peaks between 272 and 286 nm, confirming the presence of CuONPs. The XRD array had nine strong peaks at 2θ values typical of CuONPs. FTIR spectra exhibited bands associated with organic functional groups confirming capping and functionalization of the CuONPs by the phytochemicals. DLS analysis registered a net zeta potential of +12.5 mV. SEM analysis revealed that the nanoparticles were spherical and clustered with a mean diameter of 6 nm. Phytosynthesized CuONPs exhibited the highest growth suppression zones of 30 mm with MIC ranging from 30 to 125 μg/ml against MDR bacteria. Furthermore, the CuONPs achieved a methylene blue dye photocatalysis degradation efficiency of 85.5% and a free radical scavenging activity of 28.8%. PAE and CSE successfully bio-reduced copper ions to the nanoscale level with potent antimicrobial, photocatalysis, and antioxidant activities.

The increasing occurrence of active pharmaceutical ingredients (APIs) in water systems coupled with their recalcitrance to conventional water treatment methods calls for research into more eco-friendly and cost-effective curbing media. Mesoporous cassava peel activated carbon (CPAC) was prepared under conditions derived from optimizing the surface area and yield with the temperature and holding time as the model inputs using the response surface methodology. The sequestration potential and mechanisms of the resultant activated carbon (AC) for active pharmaceutical ingredients from wastewater were studied using batch experiments. The CPAC adsorption kinetics and isothermal mechanisms for the three pharmaceuticals (carbamazepine (CBZ), clarithromycin (CLN), and trimethoprim (TRM)) were studied in both wastewater and Milli-Q water. The API concentrations were measured using liquid chromatography coupled to a mass spectrometer (LC-MS) system. The maximum removal efficiencies were 86.00, 58.00, and 68.50% for CBZ, CLN, and TRM for wastewater, which were less than those from the Milli-Q water at 94.25, 73.50, and 84.5%, respectively. The sorption process for the CLN was better explained by the Freundlich model, whereas the CBZ and TRM adsorption processes could suitably be explained by both the Langmuir and Freundlich models. At an initial concentration of 20 mgL−1 for all APIs and a CPAC dosage of 2.0 gL−1, the maximum adsorption capacities were 25.907, 84.034, and 1.487 mgg−1 for CBZ, TRM, and CLN, respectively. These results demonstrated the potential of CPAC to remove APIs from water, with its sequestration potential being more exhibited after the removal of the organic matter owing to the lower competition for active sites by the APIs. Additionally, positive adsorbates were better removed than negatively charged adsorbates due to the dominance of anions in the cassava peel lattice.

Antibiotics have been the nucleus of chemotherapy since their discovery and introduction into the healthcare system in the 1940s. They are routinely used to treat bacterial infections and to prevent infections in patients with compromised immune systems and enhancing growth in livestock. However, resistance to last-resort antibiotics used in the treatment of multidrug-resistant infections has been reported worldwide. Therefore, this study aimed to evaluate green synthesized nanomaterials such as silver nanoparticles (AgNPs) as alternatives to antibiotics. UV-vis spectroscopy surface plasmon resonance peaks for AgNPs were obtained between 417 and 475 nm. An X-ray diffraction analysis generated four peaks for both Prunus africana extract (PAE) and Camellia sinensis extract (CSE) biosynthesized AgNPs positioned at 2θ angles of 38.2°, 44.4°, 64.5°, and 77.4° corresponding to crystal planes (111), (200), (220), and (311), respectively. A dynamic light-scattering analysis registered the mean zeta potential of +6.3 mV and +0.9 mV for PAE and CSE biosynthesized nanoparticles, respectively. Fourier transform infrared spectroscopy spectra exhibited bands corresponding to different organic functional groups confirming the capping of AgNPs by PAE and CSE phytochemicals. Field emission scanning electron microscopy imaging showed that AgNPs were spherical with average size distribution ranging from 10 to 19 nm. Biosynthesized AgNPs exhibited maximum growth inhibitory zones of 21 mm with minimum inhibitory concentration and minimum bactericidal concentration of 125 and 250 μg/ml, respectively, against carbapenem-resistant bacteria.

In this study, suitability of digestate from anaerobic digestion of cow dung, pig dung, and human waste feedstock as a solid fuel for thermal applications was investigated. The digestate was obtained at different retention times from laboratory scale and household digesters and later characterized. Carbonized briquettes were produced from the digestate followed by their physico-chemical characterization and assessment for combustion and mechanical properties. Results of the proximate analysis of the digestate were: moisture content (6.1 to 18.3%), volatile matter (27.9 to 47.7%), ash (15.0 to 48.9%), and fixed carbon (9.1 to 17.1%). The ultimate analysis results for the digestate were: carbon (19.5%), hydrogen (3.3%), oxygen (20.8%), and nitrogen (7.0%). The developed briquettes showed a moisture content, volatile matter, ash, and fixed carbon in the range of 3.7 to 8.9%, 9.9 to 21.5%, 45.6 to 76.4%, and 8.2 to 22.8%, respectively. Their ultimate analysis results were: carbon (21.1%), hydrogen (1.3%), oxygen (1.8%), and nitrogen (1.9%). The briquette combustion properties revealed an ignition time, burning rate, and water boiling time of 5.35 seconds, 0.16 g/min, 31.1 minutes, respectively with higher and lower heating values of 14.87 and 7.88 MJ/kg, respectively. The briquette ash compounds were sodium 1718.5 ppm, potassium 20017.8 ppm, copper 6.12 ppm, cadmium 1.22 ppm, and lead 25.6 ppm. TGA/ DTG analysis indicated high mass loss rates at 105°C and maximum energy release between 600 and 900°C. The mechanical compressive strength was between 19 and 50 MPa, with bulk density between 1.82 and 2.02 g/cm3. Thus, the briquettes from the biogas digestate demonstrate potential for domestic thermal applications in Uganda.