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2. CONTRIBUTORS

Author

Abahuje, Egide, primary, Abrahim, Orit, additional, Adetifa, Ifedayo M.O., additional, Ajjampur, Sitara S.R., additional, Alexander, Suceena, additional, PhD, Chiara Altare,, additional, Alves, Fabiana, additional, Andrianaivoarimanana, Voahangy, additional, Angelakis, Emmanouil, additional, Aronson, Jeffrey K., additional, Atukorala, Inoshi G., additional, Baily, Guy, additional, Baker, Stephen, additional, Barrett, Alan D.T., additional, Basnyat, Buddha, additional, Bastawrous, Andrew, additional, Bates, Imelda, additional, Bausch, Daniel G., additional, Baxter, Cheryl, additional, Beare, Nicholas A.V., additional, Beeching, Nick J., additional, Bekker, Linda-Gail, additional, Berlin, Anita, additional, FRS, Zulfiqar A. Bhutta, additional, Bloom, David E., additional, Blumberg, Lucille, additional, Boelaert, Marleen, additional, Brett-Major, David, additional, Brooker, Simon J., additional, Brouwer, Matthijs C., additional, Brunetti, Enrico, additional, Bull, Susan, additional, Bundy, Donald A.P., additional, Burri, Christian, additional, Bustinduy, Amaya L., additional, Caillet, Céline, additional, Chai, Jong Yil, additional, Chang, Thashi, additional, Chappuis, François, additional, Chibi, Buyisile, additional, Chiodini, Peter L., additional, Chowdhury, Rajiv, additional, Chowdhury, Sudipta Dhar, additional, Clemens, John D., additional, Cooke, Graham S., additional, Cotton, Mark F., additional, Currie, Bart J., additional, Cusack, Tomas-Paul, additional, Dance, David A.B., additional, Davis, Emily H., additional, Day, Nicholas P.J., additional, Deen, Jacqueline, additional, Dondorp, Arjen M., additional, Dünser, Martin W., additional, Eitzen, Edward, additional, Chebib, Hassan El, additional, Enria, Delia, additional, Faust, Christina, additional, Fekadu, Abebaw, additional, Fink, Günther, additional, Fischer, Peter U., additional, Fletcher, Tom, additional, Franco-Paredes, Carlos, additional, French, Neil, additional, Frumkin, Howard, additional, Garcia, Hector H., additional, Gerada, Alessandro, additional, Glass, Roger I., additional, Gordon, Stephen B., additional, Gottstein, Bruno, additional, Goyal, Alpesh, additional, Grey, Jonathan, additional, Gupta, Yashdeep, additional, Haines, Andy, additional, Hampson, Katie, additional, Hanlon, Charlotte, additional, Harrison, Mark, additional, Haswell, Melissa R., additional, Hawkesworth, Sophie, additional, Hay, Roderick J., additional, Heckmann, Jeannine M., additional, Heimesaat, Markus M., additional, Henao-Martínez, Andrés F., additional, Hien, Tran Tinh, additional, Hoerauf, Achim, additional, Irfan, Omar, additional, PhD, Euzebiusz Jamrozik, additional, Jobe, Modou, additional, John, George T., additional, Jones, Nick K., additional, Jones, Malcolm K., additional, Junghanss, Thomas, additional, Kaewkes, Sasithorn, additional, Karim, Quarraisha Abdool, additional, Keiser, Jennifer, additional, Kelly, Paul, additional, Khan, Amira M., additional, King, Charles H., additional, Kishore, Sandeep P., additional, Lang, Trudie, additional, Le, Thuy, additional, Liesenfeld, Oliver, additional, Lockwood, Diana N.J., additional, Mabey, David C.W., additional, Madkour, M. Monir, additional, Manesh, Abi, additional, Masekela, Refiloe, additional, Mäser, Pascal, additional, Mayaud, Philippe, additional, Mbanya, Dora, additional, McCarthy, James S., additional, McCartney, Daniel J., additional, McGready, Rose, additional, McKee, Martin, additional, Mc, Namara, Paul S., additional, Meara, John G., additional, Meintjes, Graeme, additional, Merson, Laura, additional, Mola, Glen, additional, Morassutti, Alessandra L., additional, Morris-Jones, Rachael, additional, Mortimer, Kevin J., additional, Muliyil, Divya Elizabeth, additional, Mumcuoglu, Kosta Y., additional, Munoz, Flor M., additional, Murphy, Adrianna, additional, Mutabingwa, Theonest, additional, Nawa, Yukifumi, additional, Newton, Paul N., additional, Nightingale, Sam, additional, Nokes, D. James, additional, Nosten, François H., additional, O’Hea, Jennifer, additional, Olliaro, Piero, additional, Ong, Jason J., additional, Oommen, Anu Mary, additional, Parashar, Umesh D., additional, Paris, Daniel H., additional, Parker, Michael, additional, Pluschke, Gerd, additional, Preidis, Geoffrey A., additional, Prentice, Andrew M., additional, Quail, Geoffrey, additional, Quinn, Thomas C., additional, Rabie, Helena, additional, Rajashekharaiah, Harsha, additional, Rajerison, Minoarisoa, additional, Ranganathan, Kannan, additional, Raoult, Didier, additional, Rassi,, Anis, additional, Ravi, Vasanthapuram, additional, Reddy, K. Srinath, additional, Rees, Claire, additional, Reynolds, Steven J., additional, Richter, Joachim, additional, Rijken, Marcus J., additional, Riviello, Robert, additional, Robinson, Janet, additional, Salazar, Juan C., additional, Schultz, Marcus J., additional, Schwarz, Dan, additional, Sendagire, Ibrahim, additional, Sharma, Savitri, additional, Shawon, Shajedur Rahman, additional, Singh, Bhagteshwar, additional, Sithithaworn, Paiboon, additional, Siwila, Joyce, additional, Solomon, Tom, additional, Spiegel, Paul, additional, Sridhar, Devi, additional, Sripa, Banchob, additional, Srour, M. Leila, additional, Stojković, Marija, additional, Strader, Christopher, additional, Suárez, Jose A., additional, Sundar, Shyam, additional, Tamarozzi, Francesca, additional, Tandon, Nikhil, additional, Tate, Jacqueline E., additional, Thachil, Jecko, additional, Thomson, Madeleine C., additional, Thwaites, Guy, additional, Thwaites, C. Louise, additional, van Daalen, Kim R., additional, Beek, Diederik van de, additional, van Doorn, H. Rogier, additional, Vega-Lopez, Francisco, additional, von Seidlein, MD, PhD, Lorenz, additional, Wakeham, Katie, additional, Walker, Stephen L., additional, Wallace, Ryan M., additional, Ward, Honorine, additional, Warrell, David A., additional, Weber, Tim Frederik, additional, Weil, Gary J., additional, White, Nicholas J., additional, White, MB Ch, B, Graham B., additional, Wong, Vanessa, additional, Wood, Robin, additional, Wood, Georgina, additional, Wyllie, Sarah, additional, Yacoub, Sophie, additional, Yen, Lam Minh, additional, Young, Paul R., additional, and Zafren, Ken, additional

Published
2024
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7. Autologous Epstein–Barr virus‐specific adoptive T‐cell therapy in a patient with lupus nephritis.

Author

Ranganathan, Dwarakanathan, Leibowitz, Saskia, John, George T, Neller, Michelle A, Ambalathingal, George R, Beagley, Leone, Panikkar, Archana, Best, Shannon, Raju, Jyothy, Reddiex, Hilary, Ratanjee, Sharad, Ng, Monica Suet Ying, Smith, Corey, and Khanna, Rajiv

Subjects
SYSTEMIC lupus erythematosus, CELLULAR immunity, GLOMERULAR filtration rate, T cells, AUTOIMMUNE diseases
Abstract

Objectives: Dysregulation of Epstein–Barr virus (EBV)‐specific cellular immunity has been hypothesised as one of the contributing factors in the pathogenesis of systemic lupus erythematosus (SLE). Lupus nephritis is a major risk factor for overall morbidity in SLE. Immune‐based strategies directed to EBV have been proposed as potential therapeutic strategy for SLE and lupus nephritis. Methods: Autologous EBV latent antigen‐specific CD4+ and CD8+ T cells were expanded in vitro and adoptively transferred to a lupus nephritis patient. Results: This adoptive immunotherapy had no immediate adverse effects, and the patient was subsequently treated with the anti‐CD20 antibody, obinutuzumab. The patient showed a reduction in anti‐dsDNA antibodies and improved glomerular filtration rate but remained nephrotic. These observations were coincident with a reduction in anti‐viral and global T‐cell activation. Conclusion: To our knowledge, this is the first report of the use of EBV‐specific adoptive immunotherapy to treat a patient with lupus nephritis. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Unrecognized Pretransplant and Donor-Derived Cryptococcal Disease in Organ Transplant Recipients

Author

Cryptococcal Collaborative Transplant Study Group, Sun, Hsin-Yun, Alexander, Barbara D., Lortholary, Olivier, Dromer, Francoise, Forrest, Graeme N., Lyon, G. Marshall, Somani, Jyoti, Gupta, Krishan L., del Busto, Ramon, Pruett, Timothy L., Sifri, Costi D., Limaye, Ajit P., John, George T., Klintmalm, Goran B., Pursell, Kenneth, Stosor, Valentina, Morris, Michele I., Dowdy, Lorraine A., Munoz, Patricia, Kalil, Andre C., Garcia-Diaz, Julia, Orloff, Susan L., House, Andrew A., Houston, Sally H., Wray, Dannah, Huprikar, Shirish, Johnson, Leonard B., Humar, Atul, Razonable, Raymund R., Fisher, Robert A., Husain, Shahid, Wagener, Marilyn M., and Singh, Nina

Published
2010

13. Lipid Formulations of Amphotericin B Significantly Improve Outcome in Solid Organ Transplant Recipients with Central Nervous System Cryptococcosis

Author

Sun, Hsin-Yun, Alexander, Barbara D., Lortholary, Olivier, Dromer, Francoise, Forrest, Graeme N., Lyon, G. Marshall, Somani, Jyoti, Gupta, Krishan L., del Busto, Ramon, Pruett, Timothy L., Sifri, Costi D., Limaye, Ajit P., John, George T., Klintmalm, Goran B., Pursell, Kenneth, Stosor, Valentina, Morris, Michelle I., Dowdy, Lorraine A., Munoz, Patricia, Kalil, Andre C., Garcia-Diaz, Julia, Orloff, Susan, House, Andrew A., Houston, Sally, Wray, Dannah, Huprikar, Shirish, Johnson, Leonard B., Humar, Atul, Razonable, Raymund R., Husain, Shahid, and Singh, Nina

Published
2009

14. Zygomycosis in Solid Organ Transplant Recipients: A Prospective, Matched Case-Control Study to Assess Risks for Disease and Outcome

Author

Singh, Nina, Aguado, Jose M., Bonatti, Hugo, Forrest, Graeme, Gupta, Krishan L., Safdar, Nasia, John, George T., Pursell, Kenneth J., Muñoz, Patricia, Patel, Robin, Fortun, Jesus, Martin-Davila, Pilar, Philippe, Bruno, Philit, François, Tabah, Alexis, Terzi, Nicolas, Chatelet, Valérie, Kusne, Shimon, Clark, Nina, Blumberg, Emily, Julia, Marino Blanes, Humar, Abhi, Houston, Sally, Lass-Flörl, Cornelia, Johnson, Leonard, Dubberke, Erik R., Barron, Michelle A., and Lortholary, Olivier

Published
2009

15. Cryptococcus neoformans in Organ Transplant Recipients: Impact of Calcineurin-Inhibitor Agents on Mortality

Author

Cryptococcal Collaborative Transplant Study Group, Singh, Nina, Alexander, Barbara D., Lortholary, Olivier, Dromer, Françoise, Gupta, Krishan L., John, George T., del Busto, Ramon, Klintmalm, Goran B., Somani, Jyoti, Lyon, G. Marshall, Pursell, Kenneth, Stosor, Valentina, Muňoz, Patricia, Limaye, Ajit P., Kalil, Andre C., Pruett, Timothy L., Garcia-Diaz, Julia, Humar, Atul, Houston, Sally, House, Andrew A., Wray, Dannah, Orloff, Susan, Dowdy, Lorraine A., Fisher, Robert A., Heitman, Joseph, Wagener, Marilyn M., and Husain, Shahid

Published
2007
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20. Unrecognized pretransplant and donor-derived cryptococcal disease in organ transplant recipients

Author

Sun, Hsin-Yun, Alexander, Barbara D., Lortholary, Olivier, Dromer, Francoise, Forrest, Graeme N., Lyon, G. Marshall, Somani, Jyoti, Gupta, Krishan L., del Busto, Ramon, Pruett, Timothy L., Sifri, Costi D., Limaye, Ajit P., John, George T., Klintmalm, Goran B., Pursell, Kenneth, Stosor, Valentina, Morris, Michele I., Dowdy, Lorraine A., Munoz, Patricia, Kalil, Andre C., Garcia-Diaz, Julia, Orloff, Susan L., House, Andrew A., Houston, Sally H., Wray, Dannah, Huprikar, Shirish, Johnson, Leonard B., Humar, Atul, Razonable, Raymund R., Fisher, Robert A., Husain, Shahid, Wagener, Marilyn M., and Singh, Nina

Subjects
Transplantation of organs, tissues, etc. -- Complications and side effects, Cryptococcal infections -- Patient outcomes, Cryptococcal infections -- Research, Cryptococcal infections -- Risk factors, Cryptococcus -- Research, Cryptococcus -- Health aspects, Health, Health care industry
Published
2010

23. An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients

Author

Singh, Nina, Lortholary, Olivier, Alexander, Barbara D., Gupta, Krishan L., John, George T., Pursell, Kenneth, Munoz, Patricia, Klintmalm, Goran B., Stosor, Valentina, del Busto, Ramon, Limaye, Ajit P., Somani, Jyoti, Lyon, Marshall, Houston, Sally, House, Andrew A., Pruett, Timothy L., Orloff, Susan, Humar, Atul, Dowdy, Lorraine, Garcia-Diaz, Julia, Kalil, Andre C., Fisher, Robert A., and Husain, Shahid

Subjects
Organ transplant recipients -- Health aspects, Cryptococcus -- Diagnosis, Cryptococcus -- Care and treatment, Health, Health care industry
Published
2005

26. The First ABO Incompatible Kidney Transplantation without Splenectomy in India -- A Review at 12 Years.

Author

John, George T., Jacob, Chakko K., Sundaram, Madhivanan, Alexander, Suceena, Kekre, Nitin S., Daniel, Dolly, and Varughese, Santosh

Subjects
*URINARY tract infection prevention, *ABO blood group system, *CHRONIC kidney failure, *KIDNEYS, *HLA-B27 antigen, *PREDNISOLONE, *IMMUNOGLOBULINS, *CO-trimoxazole, *PLASMA exchange (Therapeutics), *BLOOD plasma, *KIDNEY transplantation, *MYCOPHENOLIC acid, *ANTIBIOTIC prophylaxis, *DRUG monitoring, *VALGANCICLOVIR, *BLOOD group incompatibility, *RED blood cell transfusion, *CREATININE, *TACROLIMUS, *DRUG administration, *DRUG dosage
Published
2023
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29. Epidemiology, baseline characteristics and risk of progression in the first South-Asian prospective longitudinal observational IgA nephropathy cohort

Author

Alexander, Suceena, Varughese, Santosh, Rajanbabu Franklin, Korula, Anila, Vinoi George David, Mohapatra, Anjali, Valson, Anna T., Shibu Jacob, Koshy, Pradeep Mathew, Gautham Rajan, Daha, Mohamed R., Feehally, John, Jonathan. Barratt, and John, George T.

Abstract

Glomerular Research And Clinical Experiments- IgA Nephropathy in Indians (GRACE-IgANI) is the first prospective South Asian IgAN cohort with protocolized follow-up and extensive biosample collection. Its goals are to elucidate pathogenic pathways operating in South Asians and directly link these to clinical phenotype. Here we report the baseline clinical, biochemical and histopathological characteristics of GRACE- IgANI and calculate baseline risk of progression for the cohort. 201 adults with kidney biopsy proven primary IgAN were recruited into GRACE-IgANI between March 2015 and September 2017. As of 30th April, 2020 the cohort had completed a median follow-up of 32 (IQR 16.5-44) months.

Published
2020
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33. Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality

Author

Singh, Nina, Alexander, Barbara D., Lortholary, Olivier, Dromer, Francoise, Gupta, Krishan L., John, George T., del Busto, Ramon, Klintmalm, Goran B., Somani, Jyoti, Lyon, G. Marshall, Pursell, Kenneth, Stosor, Valentina, Munoz, Patricia, Limaye, Ajit P., Kalil, Andre C., Pruett, Timothy L., Garcia-Diaz, Julia, Humar, Atul, Houston, Sally, House, Andrew A., Wray, Danah, Orloff, Susan, Dowdy, Lorraine A., Fisher, Robert A., Heitman, Joseph, Wagener, Marilyn M., and Husain, Shahid

Subjects
Cryptococcal infections -- Risk factors, Cryptococcal infections -- Research, Organ transplant recipients -- Research, Calcineurin -- Research, Health
Published
2007

39. What do we know about chronic kidney disease in India: first report of the Indian CKD registry

Author

Rajapurkar Mohan M, John George T, Kirpalani Ashok L, Abraham Georgi, Agarwal Sanjay K, Almeida Alan F, Gang Sishir, Gupta Amit, Modi Gopesh, Pahari Dilip, Pisharody Ramdas, Prakash Jai, Raman Anuradha, Rana Devinder S, Sharma Raj K, Sahoo RN, Sakhuja Vinay, Tatapudi Ravi, and Jha Vivekanand

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background There are no national data on the magnitude and pattern of chronic kidney disease (CKD) in India. The Indian CKD Registry documents the demographics, etiological spectrum, practice patterns, variations and special characteristics. Methods Data was collected for this cross-sectional study in a standardized format according to predetermined criteria. Of the 52,273 adult patients, 35.5%, 27.9%, 25.6% and 11% patients came from South, North, West and East zones respectively. Results The mean age was 50.1 ± 14.6 years, with M:F ratio of 70:30. Patients from North Zone were younger and those from the East Zone older. Diabetic nephropathy was the commonest cause (31%), followed by CKD of undetermined etiology (16%), chronic glomerulonephritis (14%) and hypertensive nephrosclerosis (13%). About 48% cases presented in Stage V; they were younger than those in Stages III-IV. Diabetic nephropathy patients were older, more likely to present in earlier stages of CKD and had a higher frequency of males; whereas those with CKD of unexplained etiology were younger, had more females and more frequently presented in Stage V. Patients in lower income groups had more advanced CKD at presentation. Patients presenting to public sector hospitals were poorer, younger, and more frequently had CKD of unknown etiology. Conclusions This report confirms the emergence of diabetic nephropathy as the pre-eminent cause in India. Patients with CKD of unknown etiology are younger, poorer and more likely to present with advanced CKD. There were some geographic variations.

Published
2012
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41. Spectrum of biopsy proven renal disease in South Asian children: Two decades at a tropical tertiary care centre

Author

Mohapatra, Anjali, primary, Kakde, Shailesh, additional, Annapandian, Vellaichamy M, additional, Valson, Anna T, additional, Duhli, Neelaveni, additional, Korula, Anila, additional, Matthai, Smita M, additional, Pulimood, Anna B, additional, David, Vinoi G, additional, Alexander, Suceena, additional, Jacob, Shibu, additional, Varughese, Santosh, additional, Basu, Gopal, additional, Tamilarasi, Veerasamy, additional, and John, George T, additional

Published
2018
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42. Protocol and rationale for the first South Asian 5-year prospective longitudinal observational cohort study and biomarker evaluation investigating the clinical course and risk profile of IgA nephropathy: GRACE IgANI cohort

Author

Alexander, Suceena, primary, John, George T., additional, Korula, Anila, additional, Vijayakumar, T. S., additional, David, Vinoi George, additional, Mohapatra, Anjali, additional, Valson, Anna T., additional, Jacob, Shibu, additional, Koshy, Pradeep Mathew, additional, Rajan, Gautam, additional, John, Elenjickal Elias, additional, Matthai, Smita Mary, additional, Jeyaseelan, L., additional, Ponnusamy, Babu, additional, Cook, Terence, additional, Pusey, Charles, additional, Daha, Mohamed R., additional, Feehally, John, additional, Barratt, Jonathan, additional, and Varughese, Santosh, additional

Published
2018
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44. A study on occupational stressors among civil police officers of a subdivision of Thrissur district

Author

Joe Abraham, Vidhu M Joshy, John George T, and Jenyz M. Mundodan

Subjects
Stress management, business.industry, Duty hours, Stressor, Applied psychology, Microsoft excel, Police department, Medicine, Occupational stress, business, Work environment, Subdivision
Abstract

Background: Occupational stress among police officers is an extensive but neglected issue due to number of negative consequences on an individual as well as the police department. Policing is a highly demanding work environment, with constant threat to life, uncertainty at work, encounters, political pressure, exposure to violence, and death. Objectives: The objective of the study was to identify the occupation-related stressors faced by civil police officers in a subdivision in Thrissur. Materials and Methods: A cross-sectional study was conducted among civil police officers in Irinjalakuda subdivision, Kerala, from January 2017 to October 2018. The study population consisted of all civil police officers from the subdivision. Data were collected using a pre-tested structured questionnaire, which included sociodemographic variables and self-reported physical morbidities. Occupational stressors were measured using operational and organizational police stress Questionnaire. The data obtained was coded, entered in Microsoft Excel sheet and analyzed using the statistical software, Statistical Package for Social Sciences (SPSS version-23). Results: Nearly three-fourths of the participants were males and the mean age of the participants was 39.94 ± 7.067 years. Eight operational stressors were found to have a median value above four, while a median of five organizational stressors was found to be above four. “Fatigue” and “friends/family feel the stigma associated with job” were the most commonly quoted operational stressors while “staff shortages” and “bureaucratic red tape” were the most commonly quoted organizational stressors. Conclusion: Modifications such as sharing work and allotting fixed duty hours should be done to avoid stress and its adverse effects. Stress management training can be given at regular intervals to improve competency and enhance coping skills.

Published
2019
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46. Dialysis and Pregnancy in End Stage Kidney Disease Associated with Lupus Nephritis

Author

Sivasuthan, Goutham, Dahwa, Rumbi, John, George T., and Ranganathan, Dwarakanathan

Subjects
Article Subject
Abstract

Female patients with systemic lupus erythematosus are often of childbearing age at diagnosis, and though fertility in these patients is similar to the general population, successful pregnancy remains a rare occurrence. This incidence is, however, increasing and the management of these high risk pregnancies is often further complicated by the patient’s need for dialysis as a result of lupus nephritis (LN). We share our experience in managing two LN patients with successful pregnancies, one on automated peritoneal dialysis and the other on haemodialysis, as well as a review of cases in the literature.

Published
2013
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47. Low frequency of occult hepatitis B infection in anti-HBc seropositive blood donors: experience from a tertiary care centre in South India

Author

Ismail, Ashrafali M., Devakumar, Seetha, Anantharam, Raghavendran, Fletcher, Gnanadurai J., Subramani, Thenmozhi, John, George T., Daniel, Dolly, and Abraham, Priya

Subjects
Adult, Male, Hepatitis B virus, Hepatitis B Surface Antigens, Adolescent, India, Transfusion Reaction, Blood Donors, Middle Aged, Hepatitis B, Donor Selection, Young Adult, DNA, Viral, Humans, Female, Letters, Hepatitis B Antibodies, Aged
Published
2012

48. Calcific Uremic Arteriolopathy in Peritoneal Dialysis Populations

Author

New, Nicholas, Mohandas, Janaki, John, George T., Ratanjee, Sharad, Healy, Helen, Francis, Leo, and Ranganathan, Dwarakanathan

Subjects
Article Subject
Abstract

Calciphylaxis or calcific uremic arteriolopathy is an infrequent complication of end stage kidney disease. It is characterized by arteriolar medial calcification, thrombotic cutaneous ischemia, tissue necrosis often leading to ulceration, secondary infection and increased mortality rates. Current, multimodality treatment involves local wound care, well-controlled calcium, phosphate and parathyroid hormone levels and combination therapy with sodium thiosulfate and hyperbaric oxygen therapy. This combination therapy may be changing the historically poor prognosis of calcific uremic arteriolopathy reported in the literature. Peritoneal dialysis is considered a risk factor based on limited publications, however this remains to be proven. Clinical presentation, diagnosis, pathogenesis and treatment of calcific uremic arteriolopathy in these patients are no different from other patients manifesting with this condition.

Published
2011
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