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2. Interobserver variation in organs at risk contouring in head and neck cancer according to the DAHANCA guidelines

Author

Nielsen, Camilla Panduro, Lorenzen, Ebbe L., Jensen, Kenneth, Eriksen, Jesper Grau, Johansen, Jørgen, Gyldenkerne, Niels, Zukauskaite, Ruta, Kjellgren, Martin, Maare, Christian, Lønkvist, Camilla Kjær, Nowicka-Matus, Kinga, Szejniuk, Weronika Maria, Farhadi, Mohammad, Ujmajuridze, Zaza, Marienhagen, Kirsten, Johansen, Tanja Stagaard, Friborg, Jeppe, Overgaard, Jens, and Hansen, Christian Rønn

Published
2024
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6. Tumor volume and cancer stem cell expression as prognostic markers for high-dose loco-regional failure in head and neck squamous cell carcinoma – A DAHANCA 19 study

Author

Kristensen, Morten Horsholt, Sørensen, Mia Kristina, Tramm, Trine, Alsner, Jan, Sørensen, Brita Singers, Maare, Christian, Johansen, Jørgen, Primdahl, Hanne, Bratland, Åse, Kristensen, Claus Andrup, Andersen, Maria, Lilja-Fischer, Jacob Kinggaard, Holm, Anne Ivalu Sander, Samsøe, Eva, Hansen, Christian Rønn, Zukauskaite, Ruta, Overgaard, Jens, and Eriksen, Jesper Grau

Published
2024
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7. Evaluation of decentralised model-based selection of head and neck cancer patients for a proton treatment study. DAHANCA 35

Author

Hansen, Christian Rønn, Jensen, Kenneth, Smulders, Bob, Holm, Anne Ivalu Sander, Samsøe, Eva, Nielsen, Martin Skovmos, Sibolt, Patrik, Skyt, Peter, Elstrøm, Ulrik Vindelev, Nielsen, Camilla Panduro, Johansen, Jørgen, Zukauskaite, Ruta, Eriksen, Jesper Grau, Farhadi, Mohamma, Andersen, Maria, Andersen, Elo, Overgaard, Jens, Grau, Cai, and Friborg, Jeppe

Published
2024
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13. Hyperbaric oxygen treatment of mandibular osteoradionecrosis: Combined data from the two randomized clinical trials DAHANCA-21 and NWHHT2009-1

Author

Forner, Lone E., Dieleman, François J., Shaw, Richard J., Kanatas, Anastasios, Butterworth, Chris J., Kjeller, Göran, Alsner, Jan, Overgaard, Jens, Hillerup, Søren, Hyldegaard, Ole, Arnell, Per, von Buchwald, Christian, Kaanders, Johannes H.A.M., Smeele, Ludi E., Specht, Lena, Johansen, Jørgen, Witjes, Max J.H., Merkx, Matthias A.W., and Jansen, Erik C.

Published
2022
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14. Recommendations for postoperative radiotherapy in head & neck squamous cell carcinoma in the presence of flaps: A GORTEC internationally-reviewed HNCIG-endorsed consensus

Author

Carsuzaa, Florent, Lapeyre, Michel, Gregoire, Vincent, Maingon, Philippe, Beddok, Arnaud, Marcy, Pierre-Yves, Salleron, Julia, Coutte, Alexandre, Racadot, Severine, Pointreau, Yoann, Graff, Pierre, Beadle, Beth, Benezery, Karen, Biau, Julian, Calugaru, Valentin, Castelli, Joel, Chua, Melvin, Di Rito, Alessia, Dore, Melanie, Ghadjar, Pirus, Huguet, Florence, Jardel, Pauline, Johansen, Jorgen, Kimple, Randall, Krengli, Marco, Laskar, Sarbani, Mcdowell, Lachlan, Nichols, Anthony, tribius, Silke, Valduvieco, Izaskun, Hu, Chaosu, Liem, Xavier, Moya-Plana, Antoine, D'onofrio, Ida, Parvathaneni, Upendra, Takiar, Vinita, Orlandi, Ester, Psyrri, Amanda, Shenouda, George, Sher, David, Steuer, Conor, Shan Sun, Xu, Tao, Yungan, Thomson, David, Tsai, Mu-Hung, Vulquin, Noemie, Gorphe, Philippe, Mehanna, Hisham, Yom, Sue S., Bourhis, Jean, and Thariat, Juliette

Published
2021
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19. Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement

Author

Thomson, David J., Palma, David, Guckenberger, Matthias, Balermpas, Panagiotis, Beitler, Jonathan J., Blanchard, Pierre, Brizel, David, Budach, Wilfred, Caudell, Jimmy, Corry, June, Corvo, Renzo, Evans, Mererid, Garden, Adam S., Giralt, Jordi, Gregoire, Vincent, Harari, Paul M., Harrington, Kevin, Hitchcock, Ying J., Johansen, Jorgen, Kaanders, Johannes, Koyfman, Shlomo, Langendijk, J.A., Le, Quynh-Thu, Lee, Nancy, Margalit, Danielle, Mierzwa, Michelle, Porceddu, Sandro, Soong, Yoke Lim, Sun, Ying, Thariat, Juliette, Waldron, John, and Yom, Sue S.

Published
2020
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20. Individual patient data meta-analysis of FMISO and FAZA hypoxia PET scans from head and neck cancer patients undergoing definitive radio-chemotherapy

Author

Zschaeck, Sebastian, Löck, Steffen, Hofheinz, Frank, Zips, Daniel, Saksø Mortensen, Lise, Zöphel, Klaus, Troost, Esther G.C., Boeke, Simon, Saksø, Mette, Mönnich, David, Seidlitz, Annekatrin, Johansen, Jørgen, Skripcak, Tomas, Gregoire, Vincent, Overgaard, Jens, Baumann, Michael, and Krause, Mechthild

Published
2020
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23. A national repository of complete radiotherapy plans: design, Results, and experiences

Author

Krogh, Simon Long, primary, Brink, Carsten, additional, Lorenzen, Ebbe Laugaard, additional, Samsøe, Eva, additional, Vogelius, Ivan Richter, additional, Zukauskaite, Ruta, additional, Vrou Offersen, Birgitte, additional, Eriksen, Jesper Grau, additional, Hansen, Olfred, additional, Johansen, Jørgen, additional, Olloni, Agon, additional, Ruhlmann, Christina H., additional, Hoffmann, Lone, additional, Nissen, Henrik Dahl, additional, Skovmos Nielsen, Martin, additional, Andersen, Karen, additional, Grau, Cai, additional, and Hansen, Christian Rønn, additional

Published
2023
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28. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines

Author

Grégoire, Vincent, Evans, Mererid, Le, Quynh-Thu, Bourhis, Jean, Budach, Volker, Chen, Amy, Eisbruch, Abraham, Feng, Mei, Giralt, Jordi, Gupta, Tejpal, Hamoir, Marc, Helito, Juliana K., Hu, Chaosu, Hunter, Keith, Johansen, Jorgen, Kaanders, Johannes, Laskar, Sarbani Ghosh, Lee, Anne, Maingon, Philippe, Mäkitie, Antti, Micciche', Francesco, Nicolai, Piero, O'Sullivan, Brian, Poitevin, Adela, Porceddu, Sandro, Składowski, Krzysztof, Tribius, Silke, Waldron, John, Wee, Joseph, Yao, Min, Yom, Sue S., Zimmermann, Frank, and Grau, Cai

Published
2018
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30. 1687: Global dose prescription variances in oropharynx cancer

Author

Hansen, Christian Rønn, Tadic, Tony, McNiven, Andrea, Petersen, Jens, Manju, Sharma, Price, Gareth, Naser, Mohamed A., Lassen, Pernille, Overgaard, Jens, McDowell, Lachlan, Kim, Jun Won, Fuller, Clifton David, Thomson, David, Yom, Sue S., Johansen, Jørgen, Friborg, Jeppe, and Hope, Andrew

Published
2024
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31. 921: Investigating treatment plan quality for photon and proton RT in the clinical trial DAHANCA 35

Author

Nielsen, Camilla P., Jensen, Kenneth, Krogh, Simon L., Brink, Carsten, Lorenzen, Ebbe L., Smulders, Bob, Holm, Anne I.S., Samsøe, Eva, Nielsen, Martin S., Sibolt, Patrik, Skyt, Peter S., Elstrøm, Ulrik V., Johansen, Jørgen, Zukauskaite, Ruta, Eriksen, jesper G., Farhadi, Mohammad, Andersen, Maria, Maare, Christian, Overgaard, Jens, Grau, Cai, Friborg, Jeppe, and Hansen, Christian R.

Published
2024
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33. Consistency in contouring of organs at risk by artificial intelligence vs oncologists in head and neck cancer patients

Author

Nielsen, Camilla Panduro, primary, Lorenzen, Ebbe Laugaard, additional, Jensen, Kenneth, additional, Sarup, Nis, additional, Brink, Carsten, additional, Smulders, Bob, additional, Holm, Anne Ivalu Sander, additional, Samsøe, Eva, additional, Nielsen, Martin Skovmos, additional, Sibolt, Patrik, additional, Skyt, Peter Sandegaard, additional, Elstrøm, Ulrik Vindelev, additional, Johansen, Jørgen, additional, Zukauskaite, Ruta, additional, Eriksen, Jesper Grau, additional, Farhadi, Mohammad, additional, Andersen, Maria, additional, Maare, Christian, additional, Overgaard, Jens, additional, Grau, Cai, additional, Friborg, Jeppe, additional, and Hansen, Christian Rønn, additional

Published
2023
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34. Socioeconomic position and the pre-diagnostic interval among patients diagnosed with head and neck squamous cell carcinoma - a population-based study from DAHANCA

Author

Halgren Olsen, Maja, primary, Maltesen, Thomas, additional, Lassen, Pernille, additional, Kjaer, Trille Kristina, additional, Johansen, Jørgen, additional, Primdahl, Hanne, additional, Andersen, Elo, additional, Kristensen, Claus Andrup, additional, Andersen, Maria, additional, Farhadi, Mohammad, additional, Overgaard, Jens, additional, and Dalton, Susanne Oksbjerg, additional

Published
2023
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37. Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis

Author

Blanchard, Pierre, Bourhis, Jean, Lacas, Benjamin, Pignon, Jean Pierre, Bernier, Jacques, Le, Quynh-Thu, Overgaard, Jens, Parmar, Masheh KB, Trotti, Andy, Agarwal, Jai Prakash, Aupérin, Anne, Ang, Kian K, Awwad, Hassan K, Bacigalupo, Almalina, Bartelink, Harry, Benhamou, Ellen, Budach, Wilfried, Chitapanarux, Imjai, Cho, Kwan Ho, Collette, Laurence, Corvò, Renzo, Dani, Carla, Dische, Stanley, Dobrowsky, Werner, Denham, James W, Driessen, Chantal ML, Fallai, Carlo, Beadle, Beth, Laskar, Sarbani Ghosh, Ghoshal, Sushmita, Grau, Cai, Gregoire, Vincent, Hay, John H, van Herpen, Carla, Hliniak, Andrzej, Johansen, Jørgen, Kristiansen, Claus Andrup, Krstevska, Valentina, Langendijk, Johannes A., Lapeyre, Michel, Lotayef, Mohamed, Maciejewski, Boguslaw, Maingon, Philippe, Michalski, Wojciech, Moon, Sung Ho, Nilsson, Per, Olmi, Patrizia, Nankivell, Matthew, Nishiyama, Kinji, O'Sullivan, Brian, Parmar, Mahesh KB, Pignon, Jean-Pierre, Poulsen, Michael G, Ramadas, Kunnambath, Rishi, Anupam, Rosenthal, David I., Sanguineti, Giuseppe, Saunders, Michele I, Sire, Christian, Skladowski, Krzysztof, Souhami, Luis, Suwinski, Rafal, Szutkowski, Zbigniew, Tandon, Nitin, van Tinteren, Harm, Torri, Valter, Tripcony, Lee, Viegas, Celia Maria Pais, Waldron, John, Widder, Joachim, Wong, Stuart, Wu, Jonn S, Yamazaki, Hideya, Zackrisson, Björn, Zhang, Qiang, Grégoire, Vincent, Suwiński, Rafał, Poulsen, Michael, Langendijk, Johannes A, Hay, John, Parmar, Mahesh K B, and Trotti, Andy M

Published
2017
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41. Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas:a national DAHANCA study

Author

Westergaard-Nielsen, Marie, Godballe, Christian, Eriksen, Jesper Grau, Larsen, Stine Rosenkilde, Kiss, Katalin, Agander, Tina, Ulhøi, Benedicte Parm, Charabi, Birgitte Wittenborg, Klug, Tejs Ehlers, Jacobsen, Henrik, Johansen, Jørgen, Kristensen, Claus Andrup, Andersen, Elo, Andersen, Maria, Bjørndal, Kristine, Westergaard-Nielsen, Marie, Godballe, Christian, Eriksen, Jesper Grau, Larsen, Stine Rosenkilde, Kiss, Katalin, Agander, Tina, Ulhøi, Benedicte Parm, Charabi, Birgitte Wittenborg, Klug, Tejs Ehlers, Jacobsen, Henrik, Johansen, Jørgen, Kristensen, Claus Andrup, Andersen, Elo, Andersen, Maria, and Bjørndal, Kristine

Abstract

Purpose The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma. Methods All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11–102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates. Conclusion The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival., Purpose: The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma. Methods: All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results: The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11–102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates. Conclusion: The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival.

Published
2023

46. HPV testing versus p16 immunohistochemistry in oropharyngeal squamous cell carcinoma: results from the DAHANCA 19 study.

Author

Lilja-Fischer, Jacob Kinggaard, Kristensen, Morten Horsholt, Lassen, Pernille, Steiniche, Torben, Tramm, Trine, Stougaard, Magnus, Maare, Christian, Johansen, Jørgen, Primdahl, Hanne, Kristensen, Claus Andrup, Andersen, Maria, Eriksen, Jesper Grau, and Overgaard, Jens

Subjects
DNA analysis, RESEARCH, PAPILLOMAVIRUSES, CONFIDENCE intervals, IMMUNOHISTOCHEMISTRY, LOG-rank test, OROPHARYNGEAL cancer, EARLY detection of cancer, RANDOMIZED controlled trials, CANCER patients, PAPILLOMAVIRUS diseases, RESEARCH funding, DESCRIPTIVE statistics, DATA analysis software, SQUAMOUS cell carcinoma, LONGITUDINAL method
Abstract

The prognosis after primary (chemo-)radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC) is affected by Human Papillomavirus (HPV) status, with a better prognosis in HPV-positive OPSCC. HPV-status is routinely assessed by p16 immunohistochemistry (IHC), but additional HPV DNA testing is debated. Also, there are numerous HPV genotypes, which prognostic role may need clarification. The purpose of this study was: (1) to test a custom-made targeted HPV next generation sequencing (NGS) panel in OPSCC, (2) to determine correlation with p16 IHC, and (3) to assess the impact of HPV DNA testing on outcome in the prospectively randomized clinical trial DAHANCA 19. We included 271 patients with OPSCC treated with primary (chemo-)radiotherapy in the DAHANCA 19 trial. Of these, 199 (73%) were p16-positive. HPV-status was determined by targeted HPV next generation sequencing (NGS), using a custom-made HPV genotyping panel. HPV was detected in 194 tumor samples. p16 IHC and NGS HPV status were concordant in 265 (98%) of 271 patients, whereas we did not detect HPV DNA in 5 p16-positive tumors. HPV16 accounted for 169 of 194 HPV-positive cases (87%). HPV genotypes 18, 31, 33, 35, and 59 were also detected. Loco-regional failure and overall survival were similar whether patients were separated by p16 IHC, or HPV DNA status (p < 0.0001 for all) and did not depend on HPV genotype (p = 0.9 and p = 0.7). In the present study, HPV DNA testing or typing in a Danish OPSCC cohort did not add additional information to p16 IHC, the most widely used and accepted prognostic indicator. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Avviksrapportering i sykehus – et godt verktøy for læring? En kvalitativ studie om klinikernes erfaringer om det interne avvikssystemet på et norsk sykehus

Author

Johansen, Jørgen Breivik and Ofte, Hilde Karen

Subjects
VDP::Medisinske Fag: 700::Helsefag: 800::Helsetjeneste- og helseadministrasjonsforskning: 806, VDP::Medical disciplines: 700::Health sciences: 800::Health service and health administration research: 806, MED-3950
Abstract

Bakgrunn: Norske helseforetak er pålagt å drive kvalitetsforbedring for å bedre pasientsikkerhet ved norske sykehus. Det interne rapporteringssystemet er det viktigste formelle verktøyet for dette på lokalt nivå. Formål: studiens hensikt er å undersøke hvorvidt det interne avviksrapporteringssystemet bidrar til kvalitetsforbedring, og hvilke utfordringer helsepersonellet identifiserer ved bruk av systemet som læringsverktøy. Materiale og metode: Studien er basert på 8 semistrukturerte intervjuer med helsepersonell fra to avdelinger på et mellomstort norsk sykehus, analysert med tematisk analyse. Resultater: Avviksrapporteringssystemets bidrag til læring er omdiskutert og vanskelig målbart, da bidrag fra andre formelle og uformelle systemer for læring overlapper, samt at hendelser som forhindres ikke er målbare. Studien identifiserer at leder spiller en sentral rolle for avdelingenes meldekultur, og at en tydelig definisjon på avvik mangler. At avviksmeldinger kan føre til sanksjoner, og at meldekultur varierer mellom avdelinger fører til underrapportering. Informasjonshenting, analyse og problemløsning skjer ofte på siden av avvikssystemet. Avvikshåndtering er en ressurskrevende prosess, som i samspill med ressursknapphet og avvikenes kompleksitet, er hindre for kvalitetsforbedring. Tidligere kjente barrierer spiller også inn på avviksrapporteringen. Konklusjon: Basert på intervjuer av ansatte og ledere leger har vi beskrevet perspektivene på avvikssystemets bidrag til lokal pasientforbedring, og hvilke utfordringer de identifiserer med avvikssystemet som verktøy for dette. Dette er viktig for å skape et kunnskapsgrunnlag om de verktøyene vi bruker til lokal kvalitetsforbedring, og for å kunne gjøre justeringer i hvordan vi jobber med pasientforbedring i fremtiden. Videre forskning er nødvendig for å verifisere funnene.

Published
2023

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