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19. The intrafollicular concentrations of biologically active cortisol in women rise abruptly shortly before ovulation and follicular rupture

Author

Johannsen, M. L., Poulsen, L. C., Mamsen, L. S., Grøndahl, M. L., Englund, A. L. M., Lauritsen, N. L., Carstensen, E. C., Styrishave, B., Andersen, C. Yding, Johannsen, M. L., Poulsen, L. C., Mamsen, L. S., Grøndahl, M. L., Englund, A. L. M., Lauritsen, N. L., Carstensen, E. C., Styrishave, B., and Andersen, C. Yding

Abstract

STUDY QUESTION: What is the temporal activity and the concentration in follicular fluid (FF) of the anti-inflammatory steroid cortisol during the ovulatory process in humans? SUMMARY ANSWER: Intrafollicular concentrations of cortisol become massively upregulated close to ovulation concomitant with an exceptionally high biological activity securing a timely and efficient termination of inflammatory processes. WHAT IS KNOWN ALREADY: Ovulation has been described as a local, controlled inflammatory process resulting in the degeneration of the follicle wall which facilitate oocyte extrusion. Ovulation also affects the glucocorticoid metabolism of granulosa cells (GCs) and although de novo synthesis of cortisol only occurs in the adrenal cortex, the mid-cycle surge has been shown to induce a change from high expression of HSD11B2, inactivating cortisol to cortisone, to high expression of HSD11B1 which reversibly catalyses cortisol production from cortisone. Furthermore, high concentrations of progesterone and 17OH-proges-terone within follicles may cause dislodging of cortisol from cortisol binding protein (CBP) thereby activating the biological activity of cortisol. STUDY DESIGN, SIZE, DURATION: This prospective cohort study included 50 women undergoing fertility treatment according to a standard antagonist protocol at a university hospital-affiliated fertility clinic in Denmark. PARTICIPANTS/MATERIALS, SETTING, METHODS: Women donated FF and GCs from one follicle for research purpose aspirated at one of four time points during the process of final maturation of follicles: T ¼ 0 h, T ¼ 12 h, T ¼ 17 h, T ¼ 32 h. A second sample was collected at oocyte pick up at T ¼ 36 h. The concentration of cortisol and cortisone together with a range of sex steroids was measured by LC-MS/MS in FF collected at the five time points mentioned above. Whole genome microarray data, validated by q-PCR analysis, was used to evaluate gene expression of CYP11B1, CYP21A2, HSD11B1, HSD11B2, and

Published
2024

22. The intrafollicular concentrations of biologically active cortisol in women rise abruptly shortly before ovulation and follicular rupture.

Author

Johannsen, M L, Poulsen, L C, Mamsen, L S, Grøndahl, M L, Englund, A L M, Lauritsen, N L, Carstensen, E C, Styrishave, B, and Andersen, C Yding

Subjects
*OVULATION, *HYDROCORTISONE, *INDUCED ovulation, *GRANULOSA cells, *ADRENAL cortex
Abstract

STUDY QUESTION What is the temporal activity and the concentration in follicular fluid (FF) of the anti-inflammatory steroid cortisol during the ovulatory process in humans? SUMMARY ANSWER Intrafollicular concentrations of cortisol become massively upregulated close to ovulation concomitant with an exceptionally high biological activity securing a timely and efficient termination of inflammatory processes. WHAT IS KNOWN ALREADY Ovulation has been described as a local, controlled inflammatory process resulting in the degeneration of the follicle wall which facilitate oocyte extrusion. Ovulation also affects the glucocorticoid metabolism of granulosa cells (GCs) and although de novo synthesis of cortisol only occurs in the adrenal cortex, the mid-cycle surge has been shown to induce a change from high expression of HSD11B2, inactivating cortisol to cortisone, to high expression of HSD11B1 which reversibly catalyses cortisol production from cortisone. Furthermore, high concentrations of progesterone and 17OH-progesterone within follicles may cause dislodging of cortisol from cortisol binding protein (CBP) thereby activating the biological activity of cortisol. STUDY DESIGN, SIZE, DURATION This prospective cohort study included 50 women undergoing fertility treatment according to a standard antagonist protocol at a university hospital-affiliated fertility clinic in Denmark. PARTICIPANTS/MATERIALS, SETTING, METHODS Women donated FF and GCs from one follicle for research purpose aspirated at one of four time points during the process of final maturation of follicles: T  = 0 h, T  = 12 h, T  = 17 h, T  = 32 h. A second sample was collected at oocyte pick up at T  = 36 h. The concentration of cortisol and cortisone together with a range of sex steroids was measured by LC-MS/MS in FF collected at the five time points mentioned above. Whole genome microarray data, validated by q-PCR analysis, was used to evaluate gene expression of CYP11B1 , CYP21A2 , HSD11B1 , HSD11B2 , and NR3C1 in GCs at the same time points. MAIN RESULTS AND THE ROLE OF CHANCE The concentration of cortisol was significantly increased from a few nM at 0 h to around 100–140 nM (P  ≤ 0.0001) at 32–36 h, whilst cortisone was almost constant from 0 to 17 h at a concentration of between 90 and 100 nM being significantly reduced to 25–40 nM (P  ≤ 0.0001) at 32–36 h. This was paralleled by a 690-fold upregulation of HSD11B1 from 0 to 12 h increasing to a more than 20.000-fold change at 36 h. HSD11B2 was quickly downregulated 15- to 20-fold after ovulation induction. Concentrations of progesterone and 17OH-progesterone increased during the ovulatory process to high levels which in essence displaces cortisol from its binding protein CBP due to similar binding affinities. Furthermore, a significant decrease in 11-deoxycortisol expression was seen, but CYP11B1 expression was below detection limit in GCs. LIMITATIONS, REASONS FOR CAUTION The study included women undergoing ovarian stimulation and results may differ from the natural cycle. More observations at each specific time point may have strengthened the conclusions. Furthermore, we have not been able to measure the actual active biological concentration of cortisol. WIDER IMPLICATIONS OF THE FINDINGS For the first time, this study collectively evaluated the temporal pattern of cortisol and cortisone concentrations during human ovulation, rendering a physiological framework for understanding potential dysregulations in the inflammatory reaction of ovulation. STUDY FUNDING/COMPETING INTEREST(S) This research was supported by the University Hospital of Copenhagen, Rigshospitalet, and Novo Nordisk Foundation grant number NNF21OC00700556. Interreg V ÔKS through ReproUnion (www.reprounion.eu); Region Zealand Research Foundation. The funders had no role in study design, collection of data, analyses, writing of the article, or the decision to submit it for publication. The authors have no conflicts of interest to declare. TRIAL REGISTRATION NUMBER N/A. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Psychosocial predictors of posttreatment pain after nonmetastatic breast cancer treatment: a systematic review and meta-analysis of prospective studies

Author

Johannsen M, Frederiksen Y, Jensen AB, and Zachariae R

Subjects
breast cancer, pain, predictors, personality traits, social support, behavioral symptoms, Medicine (General), R5-920
Abstract

M Johannsen,1,2 Y Frederiksen,1,2 AB Jensen,3 R Zachariae1,2 1Unit for Psychoncology and Health Psychology, Department of Oncology, Aarhus University Hospital, 2Department of Psychology, Aarhus University, 3Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark Background: The search for risk factors of pain after breast cancer, which affects a considerable proportion of the women, has primarily focused on clinical factors. The aim of this meta-analysis was to explore the less well-studied psychosocial predictors of pain after breast cancer treatment. Methods: Two independent searches were conducted in PubMed, PsycINFO, Web of Science, and CINAHL. Eligible studies were prospective, observational studies of women aged ≥18 years, diagnosed and treated for nonmetastatic breast cancer ≥3 months previously. Additional inclusion criteria were that studies had assessed at least one pain outcome and at least one psychosocial predictor. The psychosocial predictors investigated included: 1) psychological–behavioral states, 2) psychological traits, and 3) social support. Effect size correlations (ESr) were chosen as the effect size and pooled using a random effects model. We also explored a number of study characteristics as possible moderators of the effect with meta-regression. Results: Of the total of 13 eligible studies identified, most studies measured psychosocial predictors at presurgery. Neither psychological–behavioral states (ESr: 0.05; p=0.13; K=11) nor psychological traits (ESr: 0.02; p=0.48; K=6) emerged as statistically significant predictors of pain. In contrast, higher levels of social support were statistically significantly associated with less pain (ESr: −0.24; p

Published
2017

24. Optimising psychological treatment for pain after breast cancer: a factorial design study protocol in Denmark.

Author

Buskbjerg, C., O'Toole, M.S., Zachariae, R., Jensen, A.B., Frederiksen, Y., Johansen, C., Heymann, A. von, Speckens, A.E.M., Johannsen, M., Buskbjerg, C., O'Toole, M.S., Zachariae, R., Jensen, A.B., Frederiksen, Y., Johansen, C., Heymann, A. von, Speckens, A.E.M., and Johannsen, M.

Abstract

Item does not contain fulltext, INTRODUCTION: One in five breast cancer (BC) survivors are affected by persistent pain years after completing primary treatment. While the efficacy of psychological interventions for BC-related pain has been documented in several meta-analyses, reported effect sizes are generally modest, pointing to a need for optimisation. Guided by the Multiphase Optimization Strategy, the present study aims to optimise psychological treatment for BC-related pain by identifying active treatment components in a full factorial design. METHODS AND ANALYSIS: The study uses a 2×3 factorial design, randomising 192 women with BC-related pain (18-75 years) to eight experimental conditions. The eight conditions consist of three contemporary cognitive-behavioural therapy components, namely: (1) mindful attention, (2) decentring, and (3) values and committed action. Each component is delivered in two sessions, and each participant will receive either zero, two, four or six sessions. Participants receiving two or three treatment components will be randomised to receive them in varying order. Assessments will be conducted at baseline (T1), session by session, every day for 6 days following the first session in each treatment component, at post-intervention (T2) and at 12-week follow-up (T3). Primary outcomes are pain intensity (Numerical Rating Scale) and pain interference (Brief Pain Inventory interference subscale) from T1 to T2. Secondary outcomes are pain burden, pain quality, pain frequency, pain catastrophising, psychological distress, well-being and fear of cancer recurrence. Possible mediators include mindful attention, decentring, and pain acceptance and activity engagement. Possible moderators are treatment expectancy, treatment adherence, satisfaction with treatment and therapeutic alliance. ETHICS AND DISSEMINATION: Ethical approval for the present study was received from the Central Denmark Region Committee on Health Research Ethics (no: 1-10-72-309-40). Findings will be made avai

Published
2023

35. Osteoprotektion unter androgendeprivativer Therapie beim knochenmetastasierten kastrationsresistenten Prostatakarzinom (mCRPC): Ergebnisse einer Umfrage von d-uo

Author

Doehn, C, Klier, J, Johannsen, M, Eichenauer, R, Schönfelder, R, Romagnolo, A, Reese, S, Nitz, C, Jaeger, A, Fieseler, C, Burkert-Scholz, M, Brenneis, H, Binder, M, Beuke, M, Schröder, J, Hempel, E, König, F, Doehn, C, Klier, J, Johannsen, M, Eichenauer, R, Schönfelder, R, Romagnolo, A, Reese, S, Nitz, C, Jaeger, A, Fieseler, C, Burkert-Scholz, M, Brenneis, H, Binder, M, Beuke, M, Schröder, J, Hempel, E, and König, F

Published
2023

38. Osteoprotektion unter androgendeprivativer Therapie beim nichtmetastasierten Prostatakarzinom (nmHSPC): Ergebnisse einer Umfrage von d-uo

Author

Klier, J, König, F, Schönfelder, R, Eichenauer, R, Johannsen, M, Beuke, M, Binder, M, Brenneis, H, Burkert-Scholz, M, Fieseler, C, Jaeger, A, Nitz, C, Reese, S, Romagnolo, A, Schröder, J, Hempel, E, Doehn, C, Klier, J, König, F, Schönfelder, R, Eichenauer, R, Johannsen, M, Beuke, M, Binder, M, Brenneis, H, Burkert-Scholz, M, Fieseler, C, Jaeger, A, Nitz, C, Reese, S, Romagnolo, A, Schröder, J, Hempel, E, and Doehn, C

Published
2023

41. Minimal-invasive Therapieoptionen beim Nierenzellkarzinom

Author

Roigas, J. and Johannsen, M.

Abstract

Zusammenfassung: Die radikale Tumornephrektomie ist die traditionelle Standardoperation zur Behandlung des Nierenzellkarzinoms. Es werden jedoch zunehmend kleinere, inzidentelle Nierentumoren diagnostiziert. Häufig sind gerade auch ältere Patienten mit erheblichen Komorbiditäten davon betroffen. Diese Situation lässt die Durchführung einer radikalen Operation mit Verlust der Niere als Standardtherapieverfahren nicht mehr gerechtfertigt erscheinen. Die offene Nierenteilresektion gilt als ein technisch komplexer Eingriff mit höherem Schwierigkeitsgrad und einer Komplikationsrate von bis zu 20%, der mit den Kriterien einer minimalen Invasivität nicht vereinbar ist. Dies öffnet den Raum für innovative minimal-invasive therapeutische Verfahren. Die laparoskopische Nierenteilresektion ist eine sehr attraktive, jedoch technisch anspruchsvolle Methode zur definitiven operativen Behandlung kleiner renaler Raumforderungen. Im Vergleich zur offenen Nierenteilresektion weist die laparoskopische Technik eine höhere Rate an Komplikationen und Reeingriffen auf. Daher ist diese Methode derzeit nicht als Standard akzeptiert und sollte laparoskopisch versierten Zentren vorbehalten bleiben. Energieablative Verfahren, wie die Kryotherapie und die Radiofrequenztherapie, gewinnen zunehmend an klinischer Bedeutung und scheinen ebenfalls effektive Behandlungsmethoden darzustellen. Den neuen Therapieverfahren ist jedoch der Mangel an Langzeitdaten zur Tumorkontrolle und zum Überleben der Patienten gemein. Daher sollten diese Verfahren derzeit nur in klinischen Studien oder als alternative Behandlungsmethode bei ausgewählten Patienten zur Anwendung kommen, bei denen ein kurativer operativer Ansatz nicht in Frage kommt. Ein weiterer alternativer Ansatz besteht in der aktiven Überwachung (Surveillance) von kleinen renalen Raumforderungen. Nach aktuellen Erkenntnissen beträgt die durchschnittliche Wachstumsgeschwindigkeit kleiner Nierentumoren nur wenige Millimeter pro Jahr. Bei Hochrisikopatienten erscheint auf der Basis dieser Beobachtungen ein initial abwartendes Verhalten durchaus gerechtfertigt.

Published
2024
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42. Associations between body composition, physical capabilities and pulmonary function in healthy older adults

Author

Schweitzer, L, Geisler, C, Johannsen, M, Glüer, C-C, and Müller, M J

Subjects
Aged -- Health aspects, Body composition -- Health aspects, Lungs -- Health aspects, Food/cooking/nutrition, Health
Abstract

Background/Objectives: There are positive associations between pulmonary function (PF) and fat-free mass as well as muscle strength. Contrarily, negative associations were found with indirect measures of visceral adipose tissue (VAT). We aimed to differentiate between associations of body composition and PF by assessing mediating and moderating effects of physical capabilities. Subjects/Methods: Cross-sectional data were assessed among 40 healthy, free-living elderly (20 males) aged 65.1-81.2 years (mean[plus or minus]s.d. age: 72.2[plus or minus]4.3 years; body mass index: 25.6[plus or minus]3.7 kg/m.sup.2). Total and regional skeletal muscle (SM), and adipose tissue (AT) were measured using whole-body magnetic resonance imaging. Muscle strength by handgrip dynamometry, physical activity (PA) by questionnaire, and physical performance by gait speed and sit-to-stand test (STS). Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV.sub.1) were assessed by spirometry. Results: Positive associations between height-standardized FVC (FVCI) as well as FEV.sub.1 (FEVI), and SM (r=0.435-0.520, P Conclusions: In healthy elderly, PF is positively associated with SM; physical capabilities mediate and moderate these relationships., Author(s): L Schweitzer [sup.1] , C Geisler [sup.1] , M Johannsen [sup.1] , C-C Glüer [sup.2] , M J Müller [sup.1] Author Affiliations: (1) Institute of Human Nutrition and Food [...]

Published
2017
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43. d-uo Versorgungsstudie zur Therapie mit Radium-223: Daten einer retrospektiven Befragung

Author

König, F, Eichenauer, R, Schönfelder, R, Johannsen, M, Klier, J, Schröder, J, Hempel, E, and Doehn, C

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Im Rahmen einer Phase III-Studie (ERA-223) wurde bei Patienten unter einer Kombinationstherapie mit Radium-223 und Abirateron ein erhöhtes Fraktur- und ein möglicherweise erhöhtes Sterberisiko festgestellt. Dies hat im Jahr 2018 zu einer Änderung des Zulassungstextes [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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44. Neudiagnose Prostatakarzinom: Daten aus der nicht-interventionellen, prospektiven VERSUS-Studie von d-uo

Author

Schönfelder, R, König, F, Eichenauer, R, Johannsen, M, Klier, J, Schröder, J, Hempel, E, and Doehn, C

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Tumorerkrankungen aus dem urologischen Gebiet machen in Deutschland etwa 37% aller Krebserkrankungen bei Männern und etwa 5% aller Krebserkrankungen bei Frauen aus (RKI 2016). Eine Voraussetzung für die Erfassung und wissenschaftliche Auswertung der Versorgungsqualität [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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45. Therapie des CRPC: Ergebnisse einer Umfrage von d-uo

Author

König, F, Eichenauer, R, Johannsen, M, Klier, J, Schönfelder, R, Schröder, J, Hempel, E, and Doehn, C

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Für Patienten mit einem kastrationsresistenten Prostatakarzinom (CRPC) stehen heute diverse Therapieansätze zur Verfügung. In der vorliegenden Arbeit haben wir die aktuelle Versorgungssituation in urologischen Praxen untersucht. Methode: Es handelte sich um eine fragebogenbasierte [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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46. Osteoprotektion unter androgendeprivativer Therapie beim nichtmetastasierten Prostatakarzinom (M0-PCa): Ergebnisse einer Umfrage von d-uo

Author

Doehn, C, Klier, J, König, F, Eichenauer, R, Johannsen, M, Schönfelder, R, Schröder, J, and Hempel, E

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Patienten mit einem Prostatakarzinom (PCa) haben oftmals bereits eine verminderte Knochendichte. Der zusätzlich ungünstige Effekt einer androgendeprivativen Therapie (ADT) auf die Knochendichte ist bekannt. Eindeutige Leitlinienempfehlungen liegen vor. In der vorliegenden Arbeit [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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47. Biopsie des Prostatakarzinoms: Antworten aus der VERSUS-Studie von d-uo

Author

Schönfelder, R, Doehn, C, Eichenauer, R, König, F, Klier, J, Schröder, J, Hempel, E, and Johannsen, M

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Seit 5/2018 dokumentieren Mitglieder von d-uo urologische Tumorerkrankungen im Rahmen der prospektiven VERSUS-Studie. In der vorliegenden Arbeit wurde die Prostatabiopsie (PBx) bei Patienten mit der Erstdiagnose Prostatakarzinom (PCa) untersucht. Methode: Bis August 2021 wurden [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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48. Osteoprotektion unter androgendeprivativer Therapie beim knochenmetastasierten kastrationsresistenten Prostatakarzinom (M1b-CRPC): Ergebnisse einer Umfrage von d-uo

Author

König, F, Eichenauer, R, Johannsen, M, Klier, J, Schönfelder, R, Schröder, J, Hempel, E, and Doehn, C

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Patienten mit einem ossär metastasierten Prostatakarzinom (PCa) und androgendeprivativer Therapie (ADT) haben oftmals eine reduzierte Knochendichte. Im Stadium der Kastrationsresistenz (mCRPC) weist eine relevante Patientenzahl eine zusätzlich reduzierte Knochendichte und somit [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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49. Neudiagnose Hodentumor: Daten aus der nicht-interventionellen, prospektiven VERSUS-Studie von d-uo

Author

Klier, J, Johannsen, M, König, F, Schönfelder, R, Eichenauer, R, Schröder, J, Hempel, E, and Doehn, C

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Tumorerkrankungen aus dem urologischen Gebiet machen in Deutschland etwa 37% aller Krebserkrankungen bei Männern und etwa 5% aller Krebserkrankungen bei Frauen aus (RKI 2016). Eine Voraussetzung für die Erfassung und wissenschaftliche Auswertung der Versorgungsqualität [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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50. Neudiagnose Peniskarzinom: Daten aus der nicht-interventionellen, prospektiven VERSUS-Studie von d-uo

Author

Doehn, C, Eichenauer, R, Klier, J, König, F, Schönfelder, R, Schröder, J, Hempel, E, and Johannsen, M

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Tumorerkrankungen aus dem urologischen Gebiet machen in Deutschland etwa 37% aller Krebserkrankungen bei Männern und etwa 5% aller Krebserkrankungen bei Frauen aus (RKI 2016). Eine Voraussetzung für die Erfassung und wissenschaftliche Auswertung der Versorgungsqualität [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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