Search

Your search keyword '"Johal, Malkiat S."' showing total 133 results
Start Over Author "Johal, Malkiat S."
133 results on '"Johal, Malkiat S."'

1. Quantitative noninvasive measurement of cerebrospinal fluid flow in shunted hydrocephalus

Author

Ha, Joseph H., primary, Borzage, Matthew T., additional, Vanstrum, Erik B., additional, Doyle, Eamon K., additional, Upreti, Meenakshi, additional, Tamrazi, Benita, additional, Nelson, Marvin, additional, Blüml, Stefan, additional, Johal, Malkiat S., additional, McComb, J. Gordon, additional, Chu, Jason, additional, Durham, Susan, additional, Krieger, Mark D., additional, Moats, Rex A., additional, and Chiarelli, Peter A., additional

Published
2024
Full Text
View/download PDF

6. LRP-1 Binds Fibrinogen in a Sialylation-Dependent Manner: A Quartz Crystal Microbalance Study

Author

Gao, Daniel L. and Johal, Malkiat S.

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality in the United States. Atherosclerosis, the dominant condition leading to CVD, is characterized by fibrofatty plaque formation. Fibrinogen, an important clotting factor, has been known to promote atherogenesis as it retains the ability to trigger smooth muscle cell proliferation, localize in areas crucial to plaque progression, and bind both platelets and leukocytes. Yet, these consequences can be suppressed through anti-inflammatory receptors like LRP-1─an endocytic receptor part of the LDLR family responsible for the endocytosis of cell debris and protein degradation products. However, the continual progression of atherosclerosis in many patients indicates that such clearance mechanisms, deemed efferocytosis, are impaired during atherosclerosis. Using the quartz crystal microbalance with dissipation monitoring (QCM-D) as a platform to investigate receptor–ligand interactions, we identify fibrinogen to be a ligand of LRP-1 and characterize its binding with LRP-1. By examining a key player in atherosclerosis development─the effect of sialidase on receptor efficacy─we found that the desialylation of LRP-1 reduces its ability to bind fibrinogen. Protein docking simulations highlighted the N-terminus portion of fibrinogen’s α domain as the LRP-1 docking site. The sialylated O-linked glycans at T894 and T935 have the potential to mediate direct binding of LRP-1 to fibrinogen and support the tertiary structure of LRP-1. These phenomena are important in showing a probable cause of defective efferocytosis that occurs readily during atherosclerosis.

Published
2023
Full Text
View/download PDF

10. Quartz resonator-based approach to ultrasonic rheology of a mixed-phase micellar system

Author

Lane, Thomas J., Cheng, Connie Y.H., Dixon, Matthew C., Oom, Anna, and Johal, Malkiat S.

Subjects
Quartz crystals -- Properties, Micelles -- Properties, Toluene -- Properties, Crystal oscillators -- Research, Rheology -- Research, Chemistry
Abstract

We report the application of a quartz crystal microbalance with dissipation monitoring (QCM-D) to rheology of mixed-phase micellar systems. This novel application of QCM-D allows for the facile monitoring of complex systems under a variety of conditions. Viscosity measurements were obtained for sodium dodecyl sulfate (SDS) solutions, ranging from 1.0 to 50.0 mg/mL, in the presence and absence of toluene. Toluene was shown to swell SDS micelles as observed through an increase in viscosity, and an inflection point designating the critical micelle concentration (CMC) was clearly visible. Aqueous SDS solutions were also stabilized with sodium chloride (NaCl), up to 1.2 M, and with n-dodecanol in toluene solutions, up to 5.0 vol %. Rodlike micelle formation and swelling with toluene were observed in both cases, supporting previous studies. These studies show that a QCM-D approach to ultrasonic rheology holds potential for the specific study of multiphase systems, non-Newtonian fluids, and low volumes of analyte, aspects highly useful for complex or expensive colloidal dispersions such as micellar or biomolecular solutions.

Published
2008

17. Tuning the optical properties of a water-soluble cationic poly(p-phenylenevinylene): surfactant complexation with a conjugated polyelectrolyte

Author

Treger, Jeremy S., Ma, Vincent Y., Yuan Gao, Chun-Chih Wang, Hsing-Lin Wang, and Johal, Malkiat S.

Subjects
Water-soluble polymers -- Optical properties, Water-soluble polymers -- Spectra, Photoluminescence -- Analysis, Chemicals, plastics and rubber industries
Abstract

The emission and absorbance properties of the novel water-soluble cationic conjugated polymer poly{2,5-bis[3-(N,N,N-triethylammonium bromide)-1-oxapropyl]-1,4-phenylenevinylene} (P2) are examined in the presence of the anionic surfactant sodium dodecylsulfate (SDS). The results can be used for developing new stable poly(p-phenylenevinylene)-based photovoltaic and electroluminescent materials with tunable optical properties.

Published
2008

19. Reversal of interfacial dipole orientation in polyelectrolyte superlattices due to polycationic layers

Author

Casson, Joanna L., Chiarelli, Peter A., McBranch, Duncan W., Johal, Malkiat S., Robinson, Jeanne M., Hsing-Lin Wang, and Roberts, Jerrad B.

Subjects
Superlattices as materials -- Research, Superlattices as materials -- Electric properties, Electrolytes -- Research, Polymers -- Research, Polymers -- Electric properties, Chemistry, Physical and theoretical -- Research, Chemicals, plastics and rubber industries
Abstract

A series of polycations are used with a common polyanion to form asymmetric polar ordered polyelectrolyte multilayered superlattices. A polycation outer layer reveal a change in chromophore orientation at the polycation/PAZO interfacial region that results in dipole reversal and leads to an attenuation of the SH signal when the polyelectrolyte film is terminated with a polycation.

Published
2000

21. Understanding Nanomaterials

Author

Johal, Malkiat S. and Johal, Malkiat S.

Subjects
Nanostructured materials, Nanochemistry
Abstract

With a selective presentation of topics that makes it accessible for students who have taken introductory university science courses, Understanding Nanomaterials is a training tool for the future workforce in nanotech development. This introductory textbook offers insights into the fundamental principles that govern the fabrication, characterizatio

Published
2011

50. Polyelectrolyte Spin-Assembly

Author

Chiarelli, Peter A., primary, Johal, Malkiat S., additional, Holmes, Daniel J., additional, Casson, Joanna L., additional, Robinson, Jeanne M., additional, and Wang, Hsing-Lin, additional

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results