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Part 1 in this series (“Nutritional Intake and Therapies in Autism”) addressed the nutrient intake of children with autism and the myriad factors likely to affect dietary intake and nutritional status. These included medical/nutritional factors (gastrointestinal symptoms/ issues, food allergies, metabolic abnormalities and/or preexisting nutrient deficiencies, and nutrition-related medication side effects) and behavioral/contextual factor subcategories (problem eating behaviors, sensory processing difficulties, and family factors). Part 2 of this 2-part series covers nutrition interventions used in autism, with emphasis on safety and efficacy as delineated by an evidence-based approach. Nutrition intervention topics will be introduced as to the scientific rationale or purported mechanism of the intervention, safety, efficacy, untoward effects, and interactions with nutrients, medications, or other dietary supplements. Broad topics of discussion include nutrition assessment of the child with autism, dietary supplements/herbs used in autism (multivitamins, probiotics, omega-3 fatty acids, vitamin B6—maganesium, melatonin, methylator pathway nutrients), and special diets, including a gluten-free, casein-free diet and the specific carbohydrate diet. Finally, behavioral/contextual interventions are discussed, and suggestions for future research to support clinical practice are proposed.