30 results on '"Joanne Chua"'
Search Results
2. Supplementary Figure 3 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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Yasumichi Hitoshi, Donald G. Payan, Rajinder Singh, Dane Goff, Polly Pine, Ralf Brandt, Joanne Chua, Ayodele Apatira, Pingyu Ding, Jing Zhang, Thilo J. Heckrodt, Jiaxin Yu, Allan Torneros, Matt Duan, Weiqun Li, Betty Chang, Yuanming Hu, Christian Franci, Alison Pan, and Sacha J. Holland
- Abstract
Supplementary Figure 3 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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- 2023
3. Supplementary Figure 6 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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Yasumichi Hitoshi, Donald G. Payan, Rajinder Singh, Dane Goff, Polly Pine, Ralf Brandt, Joanne Chua, Ayodele Apatira, Pingyu Ding, Jing Zhang, Thilo J. Heckrodt, Jiaxin Yu, Allan Torneros, Matt Duan, Weiqun Li, Betty Chang, Yuanming Hu, Christian Franci, Alison Pan, and Sacha J. Holland
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Supplementary Figure 6 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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- 2023
4. Supplementary Figure 1 A-C from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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Yasumichi Hitoshi, Donald G. Payan, Rajinder Singh, Dane Goff, Polly Pine, Ralf Brandt, Joanne Chua, Ayodele Apatira, Pingyu Ding, Jing Zhang, Thilo J. Heckrodt, Jiaxin Yu, Allan Torneros, Matt Duan, Weiqun Li, Betty Chang, Yuanming Hu, Christian Franci, Alison Pan, and Sacha J. Holland
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Supplementary Figure 1 A-C from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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- 2023
5. Supplementary Tables 1-3 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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Yasumichi Hitoshi, Donald G. Payan, Rajinder Singh, Dane Goff, Polly Pine, Ralf Brandt, Joanne Chua, Ayodele Apatira, Pingyu Ding, Jing Zhang, Thilo J. Heckrodt, Jiaxin Yu, Allan Torneros, Matt Duan, Weiqun Li, Betty Chang, Yuanming Hu, Christian Franci, Alison Pan, and Sacha J. Holland
- Abstract
Supplementary Tables 1-3 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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- 2023
6. Supplementary Figure 1 D-H from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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Yasumichi Hitoshi, Donald G. Payan, Rajinder Singh, Dane Goff, Polly Pine, Ralf Brandt, Joanne Chua, Ayodele Apatira, Pingyu Ding, Jing Zhang, Thilo J. Heckrodt, Jiaxin Yu, Allan Torneros, Matt Duan, Weiqun Li, Betty Chang, Yuanming Hu, Christian Franci, Alison Pan, and Sacha J. Holland
- Abstract
Supplementary Figure 1 D-H from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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- 2023
7. Supplementary Figure 5 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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Yasumichi Hitoshi, Donald G. Payan, Rajinder Singh, Dane Goff, Polly Pine, Ralf Brandt, Joanne Chua, Ayodele Apatira, Pingyu Ding, Jing Zhang, Thilo J. Heckrodt, Jiaxin Yu, Allan Torneros, Matt Duan, Weiqun Li, Betty Chang, Yuanming Hu, Christian Franci, Alison Pan, and Sacha J. Holland
- Abstract
Supplementary Figure 5 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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- 2023
8. Supplementary Figure 2 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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Yasumichi Hitoshi, Donald G. Payan, Rajinder Singh, Dane Goff, Polly Pine, Ralf Brandt, Joanne Chua, Ayodele Apatira, Pingyu Ding, Jing Zhang, Thilo J. Heckrodt, Jiaxin Yu, Allan Torneros, Matt Duan, Weiqun Li, Betty Chang, Yuanming Hu, Christian Franci, Alison Pan, and Sacha J. Holland
- Abstract
Supplementary Figure 2 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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- 2023
9. Supplementary Materials, Figure Legends 1-6 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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Yasumichi Hitoshi, Donald G. Payan, Rajinder Singh, Dane Goff, Polly Pine, Ralf Brandt, Joanne Chua, Ayodele Apatira, Pingyu Ding, Jing Zhang, Thilo J. Heckrodt, Jiaxin Yu, Allan Torneros, Matt Duan, Weiqun Li, Betty Chang, Yuanming Hu, Christian Franci, Alison Pan, and Sacha J. Holland
- Abstract
Supplementary Materials, Figure Legends 1-6 from R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
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- 2023
10. Validating “Look, Listen, Feel” for practical communications in the Emergency Department
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Joanne, Chua Shu Min and Lateef, Fatimah
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- 2014
- Full Text
- View/download PDF
11. Real-Time Chemical Characterization of Aerosols by Secondary Electrospray Ionization Coupled with High-Resolution Mass Spectrometry
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Tanja Zivkovic Semren, Shoaib Majeed, Maria Fatarova, Csaba Laszlo, Claudius Pak, Sandro Steiner, Guillermo Vidal, Arkadiusz Kuczaj, Anatoly Mazurov, Joanne Chua, Manuel C. Peitsch, Nikolai V. Ivanov, Julia Hoeng, and Philippe A. Guy
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
12. Use of micro-CT to determine tracheobronchial airway geometries in three strains of mice used in inhalation toxicology as disease models
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Joanne Chua, Francesco Lucci, Clement Foong, Julia Hoeng, Arkadiusz K. Kuczaj, Steve Cockram, Demetrius Yeo, Manual C. Peitsch, Michael J. Oldham, Bahman Asgharian, and Stephen M. Luke
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0301 basic medicine ,Histology ,FULL LENGTH ARTICLES ,Inhalation Toxicology ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Human disease ,Apolipoproteins E ,Pulmonary Biology ,Full Length Article ,Medicine ,Dosimetry ,Animals ,Mouse Lung ,Micro ct ,Ecology, Evolution, Behavior and Systematics ,Aerosols ,Inhalation Exposure ,Lung ,business.industry ,X-Ray Microtomography ,respiratory system ,Branch angle ,respiratory tract diseases ,Mice, Inbred C57BL ,Trachea ,Disease Models, Animal ,030104 developmental biology ,medicine.anatomical_structure ,Anatomy ,business ,Nuclear medicine ,Airway ,030217 neurology & neurosurgery ,Biotechnology - Abstract
Aerosol dosimetry estimates for mouse strains used as models for human disease are not available, primarily because of the lack of tracheobronchial airway morphometry data. By using micro‐CT scans of in‐situ prepared lung casts, tracheobronchial airway morphometry for four strains of mice were obtained: Balb/c, AJ, C57BL/6, and Apoe−/−. The automated tracheobronchial airway morphometry algorithms for airway length and diameter were successfully verified against previously published manual and automated tracheobronchial airway morphometry data derived from two identical in‐situ Balb/c mouse lung casts. There was also excellent agreement in tracheobronchial airway length and diameter between the automated and manual airway data for the AJ, C57BL/6, and Apoe−/− mice. Differences in branch angle measurements were partially due to the differences in definition between the automated algorithms and manual morphometry techniques. Unlike the manual airway morphometry techniques, the automated algorithms were able to provide a value for inclination to gravity for each airway. Inclusion of an inclination to gravity angle for each airway along with airway length, diameter, and branch angle make the current automated tracheobronchial airway data suitable for use in dosimetry programs that can provide dosimetry estimates for inhaled material. The significant differences in upper tracheobronchial airways between Balb/c mice and between C57BL/6 and Apoe−/− mice highlight the need for mouse strain‐specific aerosol dosimetry estimates.
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- 2020
13. What are the characteristics of first time older sexual offenders?
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Susan Hatters Friedman, Joanne Chua, Gary Cheung, and Sigourney Taylor
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030214 geriatrics ,Sex Offenses ,05 social sciences ,MEDLINE ,Human factors and ergonomics ,Poison control ,PsycINFO ,Violence ,Suicide prevention ,Occupational safety and health ,03 medical and health sciences ,Psychiatry and Mental health ,Clinical Psychology ,0302 clinical medicine ,Injury prevention ,050501 criminology ,Humans ,Geriatrics and Gerontology ,Cognition Disorders ,Psychology ,Gerontology ,Neurocognitive ,Aged ,0505 law ,Clinical psychology - Abstract
Background:Our objective was to examine and describe the common socio-demographic and clinical characteristics of first time older sex offenders.Methods:Research papers published in MEDLINE, PsycINFO, and EMBASE were searched systematically. Following removal of duplicates and irrelevant papers, a total of 423 papers were reviewed to determine whether the selection criteria were met. A total of seven publications were included and evaluated by two researchers.Results:Of the seven publications, there were two retrospective research studies and five case reports. There was a higher proportion of neurocognitive disorder in this offender group and the victims were usually vulnerable individuals. Yet, cognitive assessments were rarely done or reported. Two subtypes of older sex offenders were identified: (i) offenders who had offended in the past but were not previously detected; (ii) first-time offenders with a high proportion of neurocognitive disorder.Conclusion:There is a paucity of research in first time sex offending by older people. This review has highlighted a need for better designed studies to explore the characteristics of older sex offenders. Better collaboration between forensic and old-age psychiatric services is required for improved assessment and management of older sex offenders.
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- 2017
14. A method for determination of tracheobronchial airway geometries from four different strains of mice
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Michael J. Oldham, Manuel C. Peitsch, Francesco Lucci, Steve Cockram, Stephen M. Luke, Arkadiusz K. Kuczaj, Clement Foong, Demetrius Yeo, Julia Hoeng, and Joanne Chua
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Pathology ,medicine.medical_specialty ,Chemistry ,Genetics ,medicine ,Airway ,Molecular Biology ,Biochemistry ,Biotechnology - Published
- 2019
15. Do caregivers of cancer patients receiving care in home hospice services have better quality of life? An exploratory investigation in Singapore
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Ee Heok Kua, Konstadina Griva, Sally Wai-Chi Chan, Moon Fai Chan, Joanne Chua, Rathi Mahendran, Haikel A. Lim, Russell K. L. Yoong, and Mabel Qi He Leow
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medicine.medical_specialty ,business.industry ,Cross-sectional study ,MEDLINE ,Terminally ill ,Cancer ,Experimental and Cognitive Psychology ,medicine.disease ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Quality of life (healthcare) ,Oncology ,Nursing ,030220 oncology & carcinogenesis ,Family medicine ,medicine ,030212 general & internal medicine ,Young adult ,business ,Home Hospice ,Hospice care - Published
- 2015
16. Psychosocial concerns of cancer patients in Singapore
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Joanne Chua, Haikel A. Lim, Rathi Mahendran, Ee Heok Kua, and Siew Eng Lim
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medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Problem list ,General Medicine ,Hospital Anxiety and Depression Scale ,Affect (psychology) ,03 medical and health sciences ,Distress ,0302 clinical medicine ,Oncology ,Quality of life ,030220 oncology & carcinogenesis ,Cohort ,Medicine ,030212 general & internal medicine ,Worry ,business ,Psychiatry ,Psychosocial ,media_common - Abstract
Aims Psychosocial needs are high among cancer patients, and screening for these is recognized as integral to quality cancer care. This study identified the psychosocial needs of cancer patients at their first visit at a hematology-oncology clinic. Methods Fifty-four new consecutive patients completed the Distress Thermometer and the Problem List, the Hospital Anxiety and Depression Scale, and the EuroQol Quality of Life Scale at their first visit to plan for chemotherapy. Data were analyzed with SPSS. Results Analyses revealed that participants had an average of 2.8 ± 2.3 problems, with 82% having psychosocial needs. Emotional concerns formed the top four psychosocial needs of the cohort (worry 46%, fears 26%, nervousness 26%, sadness 24%), with the fifth being a practical concern (insurance/finance 22%). The former were more frequent among 41- to 50-year-olds and significantly correlated with distress scores. Practical concerns were significantly correlated with depressive symptoms. Family concerns were more significant in women. The overall score on the Problem List correlated with distress, anxious symptomatology and poorer quality of life scores. Conclusions Distress and psychosocial needs are high in cancer patients even at an early stage prior to chemotherapy. Attention to these needs is crucial as they cause significant distress and affect the patient's quality of life.
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- 2015
17. Strengthening Resilience and Reducing Stress in Psychosocial Care for Nurses Practicing in Oncology Settings
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Emily Ang, Ee Heok Kua, Rathi Mahendran, Jianlin Liu, Joanne Chua, Haikel A. Lim, and Joyce Y. S. Tan
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Adult ,Male ,Oncology ,medicine.medical_specialty ,Attitude of Health Personnel ,MEDLINE ,Nursing Staff, Hospital ,Burnout ,Patient care ,Education ,03 medical and health sciences ,Education, Nursing, Continuing ,0302 clinical medicine ,Nursing ,Neoplasms ,Internal medicine ,Stress (linguistics) ,medicine ,Humans ,030212 general & internal medicine ,Resilience (network) ,Burnout, Professional ,Curriculum ,Qualitative Research ,General Nursing ,030504 nursing ,business.industry ,Oncology Nursing ,Middle Aged ,Resilience, Psychological ,Review and Exam Preparation ,Family medicine ,Female ,0305 other medical science ,business ,Psychosocial ,Stress, Psychological ,Qualitative research - Abstract
The current study examined whether continuing education programs on psychosocial oncology patient care would improve nurses' resilience and reduce their stress. Analyses revealed postprogram improvements in resilience, which was related to reduction in stress. Findings provide preliminary evidence that such programs may also be helpful in other domains. J Contin Educ Nurs. 2016;47(1):8–10.
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- 2016
18. Quality of life of family caregivers of cancer patients in Singapore and globally
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Ee Heok Kua, Rathi Mahendran, Joyce Ys Tan, Haikel A. Lim, Russell K. L. Yoong, Joanne Chua, and Siew Eng Lim
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Gerontology ,Adult ,Male ,medicine.medical_specialty ,Canada ,Adolescent ,Turkey ,Cross-sectional study ,Exploratory research ,Ethnic group ,Taiwan ,Iran ,Global Health ,03 medical and health sciences ,Social support ,Young Adult ,0302 clinical medicine ,Quality of life ,Cultural diversity ,Neoplasms ,Surveys and Questionnaires ,Republic of Korea ,Medicine ,Humans ,030212 general & internal medicine ,Young adult ,Sex Distribution ,Aged ,Family Health ,Singapore ,business.industry ,Family caregivers ,Social Support ,General Medicine ,Middle Aged ,United States ,Cross-Sectional Studies ,Caregivers ,030220 oncology & carcinogenesis ,Family medicine ,Quality of Life ,Original Article ,Female ,business - Abstract
INTRODUCTION Family caregivers of cancer patients often suffer from impaired quality of life (QOL) due to stress arising from the responsibility of caregiving. Most research on such QOL impairments was conducted in Western populations. Thus, this exploratory study sought to (a) examine the QOL levels of family caregivers of cancer patients in an Asian population in Singapore, in relation to caregivers from other countries within and outside of Asia; and (b) investigate the association between sociodemographic factors and QOL impairments in family caregivers in Singapore. METHODS A total of 258 family caregivers of cancer patients who were receiving outpatient treatment completed the Caregiver Quality of Life Index-Cancer (CQOLC) and a sociodemographic survey. We compared the published CQOLC total scores from Turkey, Iran, Taiwan, South Korea, the United Kingdom, the United States and Canada with the Singapore dataset and examined the demographic relationships. RESULTS Caregivers in Singapore and Asia had lower CQOLC total scores than their Western counterparts. Caregivers who were male, of Chinese ethnicity, had parental relationships with their care recipient, or cared for advanced-stage cancer patients were found to have impaired QOL. CONCLUSION The findings of this study highlight possible areas in which support can be provided for family caregivers of cancer patients, and underscore the need to reconcile cultural diversity, values, societal expectations and demographic characteristics in Singapore.
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- 2017
19. Evaluation of a brief pilot psychoeducational support group intervention for family caregivers of cancer patients: a quasi-experimental mixed-methods study
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Konstadina Griva, Joyce Y. S. Tan, Huiying Ng, Joanne Chua, Ee Heok Kua, Siew Eng Lim, Haikel A. Lim, and Rathi Mahendran
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Quality of life ,Male ,Asia ,medicine.medical_treatment ,Short Report ,Family caregivers ,Pilot Projects ,Anxiety ,Hospital Anxiety and Depression Scale ,Support group ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Intervention (counseling) ,Adaptation, Psychological ,medicine ,Psychoeducation ,Humans ,030212 general & internal medicine ,Psychosocial intervention ,Cancer ,Aged ,Depression ,business.industry ,Public Health, Environmental and Occupational Health ,General Medicine ,Middle Aged ,Self-Help Groups ,Oncology ,Caregivers ,Supportive psychotherapy ,Case-Control Studies ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,business ,Clinical psychology - Abstract
Family caregivers of cancer patients often experience an impaired quality of life (QOL) and emotional distress as a result of their caregiving duties, which may potentially influence the quality of care of their care recipients. The COPE (Caregivers of cancer Outpatients’ Psycho-Education support group therapy) intervention was developed as a response to the lack of work done among family caregivers of ambulatory cancer patients in Asia. This group intervention comprised four weekly sessions simultaneously targeting psychoeducation, skills training, and supportive therapy. The present study sought to evaluate the pilot COPE intervention using both quantitative and qualitative measures. The Hospital Anxiety and Depression Scale (HADS) was used to measure both depression and anxiety, while the Caregiver QOL – Cancer (CQOLC) measured caregiver QOL. These instruments were measured at baseline pre-intervention, and immediately post-intervention. A waitlist control group design was adopted. A subset of caregivers from the intervention group were invited for a semi-structured interview post-intervention. Quantitative analyses suggest that while QOL remained stable in control group participants, intervention group participants experienced QOL improvements – both in overall QOL and in the specific domain of burden. There were no significant differences in the trajectories of depression and anxiety in both groups. Qualitative analyses suggest that this might have been a result of the intervention not only equipping participants with the relevant coping skills, but also providing a platform for emotional expression and situational reappraisal. The COPE intervention has shown some efficacy in helping family caregivers of cancer patients, but more work is required before this can be implemented. Current Controlled Trials NCT02120183 . Registered 17 April 2014. Retrospectively registered.
- Published
- 2017
20. The Distress Thermometer as an ultra-short screening tool: A first validation study for mixed-cancer outpatients in Singapore
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Rathi Mahendran, Chao Xu Peh, Ee Heok Kua, Joanne Chua, Haikel A. Lim, and Siew-Eng Lim
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Male ,medicine.medical_specialty ,Psychometrics ,lcsh:RC435-571 ,Population ,Problem list ,Anxiety ,Hospital Anxiety and Depression Scale ,Quality of life ,Internal medicine ,Neoplasms ,lcsh:Psychiatry ,Outpatients ,medicine ,Humans ,Affective Symptoms ,education ,Depression (differential diagnoses) ,Psychiatric Status Rating Scales ,education.field_of_study ,Singapore ,business.industry ,Depression ,Middle Aged ,Psychiatry and Mental health ,Clinical Psychology ,Distress ,Quality of Life ,Female ,medicine.symptom ,business ,Stress, Psychological ,Clinical psychology - Abstract
Introduction: Research has shown that single-item tools, like the Distress Thermometer (DT), are comparable to longer ones, like the Hospital Anxiety and Depression Scale (HADS). In this study, we tested the validity of the DT in a population of Singapore cancer outpatients, and determined the cut-off scores on the DT for clinically relevant distress and an impaired quality of life (QOL). We also documented the prevalence of anxiety, depression, and QOL impairments in this population. Methods: One hundred and five patients (Mdn age = 51–60 years, 64% female, and 71% Chinese) diagnosed with various cancers participated in this study. They completed a standard socio-demographic form, the DT and the Problem List, the HADS, and the EuroQOL Quality of Life Scale (EQ-5D). Results: Almost a third of patients had clinically significant emotional distress, with 15%–16% having probable levels of anxiety and depression. Almost half (41%–55%) had an impaired QOL compared to Singapore population norms. Receiver operating characteristic curve analyses identified an area under the curve of 0.89 (SE = 0.36, 95% CI [0.82, 0.96], p
- Published
- 2014
21. Knowledge, attitudes, and practice behaviors (KAPb) of nurses and the effectiveness of a training program in psychosocial cancer care
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Ee Heok Kua, Chao Xu Peh, Haikel A. Lim, Joanne Chua, Rathi Mahendran, Siew Eng Lim, and Emily Ang
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Male ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,Attitude of Health Personnel ,media_common.quotation_subject ,Nurses ,Education, Nursing, Continuing ,Quality of life (healthcare) ,Nursing ,Neoplasms ,Surveys and Questionnaires ,Humans ,Medicine ,Nurse education ,Empowerment ,Curriculum ,media_common ,Singapore ,business.industry ,Nursing research ,Oncology Nursing ,Distress ,Oncology nursing ,Oncology ,Family medicine ,Female ,business ,Psychosocial - Abstract
Psychosocial distress in oncology patients may significantly interfere with their health outcomes and quality of life. Nurses work closely with their patients and are in the best position to screen for distress and provide timely intervention. It is thus important for nurses working in oncology settings to be equipped and prepared to address distressing psychosocial issues. The present study aims to investigate the impact of a training program in psychosocial care on nurses’ knowledge, attitudes, and clinical practice behaviors. A total of 180 nurses working in medical oncology and radiation oncology departments at the National University Cancer Institute Singapore underwent a training program in psychosocial care as part of their continuing nursing education curriculum. One hundred fifty four of these nurses completed a self-designed questionnaire on nurses’ knowledge, attitudes, and practice behaviors (KAPb) at all four time points: baseline, post-training, and at 6 and 12 weeks post-training, respectively. The self-designed KAPb questionnaire proved adequate for this study. Positive gains on applied knowledge and practice behaviors were sustained over a 12-week period. There were no changes in theoretical knowledge. A decreasing trend in attitudes was noted, although this was specific to the participants’ attitudes toward the importance of emotional concerns as compared to physical concerns in cancer treatment. Enrolled nurses seemed to have higher starting levels of theoretical knowledge than their registered counterparts were. There were no other differences on demographic variables in relation to the efficacy of the training program. The training program was successful in improving the applied knowledge and practice behaviors of nurses in providing psychosocial care for cancer patients. However, further refinement to the program, with particular attention to nurses’ existing training and years of clinical nursing experience, would enhance staff empowerment and care improvement.
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- 2014
22. Psychosocial concerns of cancer patients in Singapore
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Rathi, Mahendran, Haikel A, Lim, Joanne, Chua, Siew Eng, Lim, and Ee Heok, Kua
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Adult ,Aged, 80 and over ,Male ,Singapore ,Middle Aged ,Young Adult ,Neoplasms ,Surveys and Questionnaires ,Quality of Life ,Humans ,Psychology ,Female ,Stress, Psychological ,Aged - Abstract
Psychosocial needs are high among cancer patients, and screening for these is recognized as integral to quality cancer care. This study identified the psychosocial needs of cancer patients at their first visit at a hematology-oncology clinic.Fifty-four new consecutive patients completed the Distress Thermometer and the Problem List, the Hospital Anxiety and Depression Scale, and the EuroQol Quality of Life Scale at their first visit to plan for chemotherapy. Data were analyzed with SPSS.Analyses revealed that participants had an average of 2.8 ± 2.3 problems, with 82% having psychosocial needs. Emotional concerns formed the top four psychosocial needs of the cohort (worry 46%, fears 26%, nervousness 26%, sadness 24%), with the fifth being a practical concern (insurance/finance 22%). The former were more frequent among 41- to 50-year-olds and significantly correlated with distress scores. Practical concerns were significantly correlated with depressive symptoms. Family concerns were more significant in women. The overall score on the Problem List correlated with distress, anxious symptomatology and poorer quality of life scores.Distress and psychosocial needs are high in cancer patients even at an early stage prior to chemotherapy. Attention to these needs is crucial as they cause significant distress and affect the patient's quality of life.
- Published
- 2014
23. Psychosocial Care for Cancer Patients—Too Little, Too Late?
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Rathi Mahendran, Joanne Chua, Eugene Wuan, Emily NK Ang, Siew Eng Lim, and Ee Heok Kua
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General Medicine - Abstract
Assessment of psychosocial and psychiatric needs is an increasingly important component of cancer care. Clinical experience with patients indicate that distress, anxiety and depression are prevalent from early stages of the illness. Strategies to enhance psychosocial care are presented and these include early identification through screening, training for healthcare staff working with cancer patients and support not only for patients but their caregivers as well. Key words: Distress, Emotional Needs, Social Needs
- Published
- 2013
24. The Caregiver Quality of Life Index-Cancer (CQOLC) in Singapore: a new preliminary factor structure for caregivers of ambulatory patients with cancer
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Haikel A. Lim, Siew Eng Lim, Rathi Mahendran, Joanne Chua, Chao Xu Peh, and Ee Heok Kua
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Gerontology ,Adult ,Male ,medicine.medical_specialty ,Cross-sectional study ,Social support ,Young Adult ,Ambulatory care ,Quality of life ,Neoplasms ,Surveys and Questionnaires ,Ambulatory Care ,Medicine ,Humans ,Young adult ,Health Services Needs and Demand ,Singapore ,Cultural Characteristics ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,Reproducibility of Results ,Social Support ,Middle Aged ,Cross-Sectional Studies ,Caregivers ,Socioeconomic Factors ,Scale (social sciences) ,Ambulatory ,Quality of Life ,Female ,business ,Factor Analysis, Statistical - Abstract
The Caregiver Quality of Life Index–Cancer (CQOLC) is used worldwide to determine levels of quality of life of caregivers of patients with cancer; however, the few studies examining the underlying factor structure of the CQOLC have revealed differences between Western and Eastern cultures. This study sought to confirm the differences in the factor structures between the original CQOLC and a Taiwanese (Mandarin) version. A total of 183 caregivers from a cancer center in Singapore participated in this exploratory cross-sectional study. All participants completed the CQOLC and a sociodemographic form; 30 participants repeated the CQOLC two weeks later. Test–retest reliability was adequate for the CQOLC; however, confirmatory factor analyses did not support either the original four-factor model or the Taiwanese five-factor model. Exploratory factor analyses suggested the retaining of five factors to form a 25-item Singapore version (CQOLC-S25): burden, physical/practical concerns, emotional reactivity, self-needs, and social support. Inter-factor and factor scale correlations were positively significant for all factors except Support, which was negatively correlated with emotional reactivity and self-needs. Cross-cultural differences, which require further investigations, appear to underlie the utility and understanding of the CQOLC. More research is needed to better understand the needs of Singapore caregivers.
- Published
- 2014
25. A pilot, quasi-experimental, mixed methods investigation into the efficacy of a group psychotherapy intervention for caregivers of outpatients with cancer: the COPE study protocol
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Huiying Ng, Rathi Mahendran, Joanne Chua, Haikel A. Lim, Siew Eng Lim, Konstadina Griva, Ee Heok Kua, and Joyce Y. S. Tan
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Adult ,Male ,Research design ,medicine.medical_specialty ,medicine.medical_treatment ,Psychological intervention ,Pilot Projects ,Group psychotherapy ,Young Adult ,Quality of life (healthcare) ,Ambulatory care ,Informed consent ,Neoplasms ,Outpatients ,Protocol ,Humans ,Medicine ,Psychiatry ,Aged ,Psychiatric Status Rating Scales ,Singapore ,Depression ,business.industry ,Family caregivers ,General Medicine ,Middle Aged ,QUALITATIVE RESEARCH ,ONCOLOGY ,Self Efficacy ,Mental Health ,Caregivers ,Research Design ,Psychotherapy, Group ,Quality of Life ,PSYCHIATRY ,Female ,business ,Psychosocial ,Stress, Psychological - Abstract
Introduction Despite the rising trend of cancer prevalence and increase in family caregiving, little attention has been paid to the efficacy of psychosocial interventions among Asian caregiver samples, particularly support groups, given the benefits that have been shown in studies on Western populations. This trial aims to evaluate the effectiveness of a pilot 4-week group psychotherapy for Singaporean family caregivers of patients receiving outpatient care. Methods and analysis Facilitated by a clinical psychologist, this intervention is primarily based on the brief integrative psychological therapy with a supportive-expressive intent. Participants will be recruited while they are accompanying their care recipients for outpatient consultations. Since this is a pilot study, a sample size of 120 participants is targeted on the basis of sample sizes of previous studies. The study adopts a quasi-experimental design, as participants are assigned the intervention or control arms based on their availability to attend the intervention. A mixed methods approach is used to evaluate the outcomes of the intervention. A self-administered battery of tests is completed at four time points: baseline, postintervention and follow-up at 1-month and 2-month postinterventions; semi-structured interviews are conducted at baseline and post-intervention. Primary outcomes are quality of life and anxious and depressive symptoms; secondary outcomes are stress and basic psychological needs. Analysis using analysis of covariance would be conducted to determine the effectiveness of the intervention. Ethics and dissemination This study protocol has ethics approval from the National Healthcare Group Domain Specific Review Board (NHG DSRB Ref: 2013/00662). Written informed consent is obtained from every participant. Results will be disseminated through journals and conferences, and will be particularly relevant for clinicians intending to implement similar support groups to address the psychosocial concerns of caregivers, as well as for researchers seeking to refine the structure and evaluate the effectiveness of such programmes. Trial registration number Current Controlled Trials NCT02120183 (https://clinicaltrials.gov/show/NCT02120183)
- Published
- 2015
26. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer
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Matt Duan, Thilo Heckrodt, Weiqun Li, Alison Pan, Christian Franci, Dane Goff, Joanne Chua, Betty Chang, Donald G. Payan, Ralf Brandt, Polly Pine, Zhang Jing, Yasumichi Hitoshi, Rajinder Singh, Jiaxin Yu, Allan Torneros, Ayodele Apatira, Pingyu Ding, Sacha Holland, and Yuanming Hu
- Subjects
Cancer Research ,Mice, Nude ,Antineoplastic Agents ,Breast Neoplasms ,Metastasis ,Mice ,Breast cancer ,Proto-Oncogene Proteins ,Tumor Cells, Cultured ,Medicine ,Animals ,Humans ,Neoplasm Invasiveness ,Neoplasm Metastasis ,Protein Kinase Inhibitors ,Oncogene Proteins ,Mice, Inbred BALB C ,AXL receptor tyrosine kinase ,business.industry ,GAS6 ,Mouse models of breast cancer metastasis ,Carcinoma ,Cancer ,Receptor Protein-Tyrosine Kinases ,Triazoles ,medicine.disease ,Metastatic breast cancer ,Survival Analysis ,Xenograft Model Antitumor Assays ,Axl Receptor Tyrosine Kinase ,Benzocycloheptenes ,Oncology ,Immunology ,Cancer research ,Female ,Breast disease ,business ,K562 Cells ,HeLa Cells - Abstract
Accumulating evidence suggests important roles for the receptor tyrosine kinase Axl in cancer progression, invasion, metastasis, drug resistance, and patient mortality, highlighting Axl as an attractive target for therapeutic development. We have generated and characterized a potent and selective small-molecule inhibitor, R428, that blocks the catalytic and procancerous activities of Axl. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metastatic tumors. Cancer Res; 70(4); 1544–54
- Published
- 2010
27. The Flipped Classroom: Viewpoints in Asian Universities.
- Author
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Joanne, Chua Shu Min and Lateef, Fatimah
- Subjects
- *
FLIPPED classrooms , *TEACHING , *PROBLEM solving , *DISTANCE education , *INTERNET in education - Abstract
Introduction: The flipped classroom is a radical pedagogy whereby online lectures take place outside class, and the conventional classroom is used for active problem solving. It has successfully met the approval of students and teachers alike in the Western world. Objective: This paper aims to evaluate the response to flipped classroom teaching in Asian schools. Asian students stereotypically learn differently from their Western counterparts hence their receptivity to flipped classrooms may also vary. Method and Result: Collective results from twelve case studies carried out in Asia reflect a positive response from majority of the Asian students who experienced the flipped classroom. Conclusion: The flipped classroom, although a relatively new model of practice in Asia, appears to be gaining momentum and is well-received. These findings not only fuel the necessity for more resources to be channelled into furthering the potential of the flipped classroom in Asia, they can also be of special value to schools with a strong international culture worldwide. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
28. Subject Index Vol. 57, 2001
- Author
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Tangi R. Summers, Joanne Chua, Shu-Rong Wang, Cliff H. Summers, Manuel F. Casanova, H.-J. Wagner, Jing Hu, Richard E. Wilcoxb, Daniel P. Buxhoeveden, Patrick J. Ronan, Mark S. Litaker, Andrew E. Switala, Wayne J. Korzan, Emil Roy, Walter Wilczynskia, and Kenneth J. Renner
- Subjects
Cognitive science ,Behavioral Neuroscience ,Index (economics) ,Developmental Neuroscience ,Subject (documents) ,Psychology - Published
- 2001
29. Contents Vol. 57, 2001
- Author
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Manuel F. Casanova, Wayne J. Korzan, Joanne Chua, Shu-Rong Wang, Richard E. Wilcoxb, Tangi R. Summers, Cliff H. Summers, Patrick J. Ronan, Walter Wilczynskia, H.-J. Wagner, Emil Roy, Kenneth J. Renner, Jing Hu, Daniel P. Buxhoeveden, Mark S. Litaker, and Andrew E. Switala
- Subjects
Behavioral Neuroscience ,Developmental Neuroscience - Published
- 2001
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