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Several forms of virtual reality (VR) have shown promise in treating mental disorders. However, there is a lack of research investigating the use of multicomponent immersive VR. Therefore, this study aimed to evaluate the effectiveness of an immersive virtual reality (IVR) intervention that incorporated Japanese garden aesthetics, relaxation, and elements of Erickson’s psychotherapy in alleviating depression and anxiety symptoms among elderly women. Sixty women with depressive symptoms were randomly assigned to one of two treatment groups. Both groups received eight (twice a week for four weeks) low-intensity general fitness training sessions. The IVR group (n = 30) received eight additional VR-based relaxation sessions, whereas the control group (n = 30) received eight group relaxation. As outcome measures, the geriatric depression scale (GDS; primary) and Hospital Anxiety and Depression Scale (HADS; secondary) were administered before and after the interventions. The protocol was registered in the ClinicalTrials.gov PRS database (Registration number: NCT05285501). Patients receiving IVR therapy exhibited a greater significant reduction in the GDS (adjusted mean post-difference of 4.10; 95% CI = 2.27–5.93) and HADS (2.95; 95% CI = 0.98–4.92) scores than those receiving the control intervention. In conclusion, IVR with elements of psychotherapy, relaxation, and garden aesthetics may alleviate the severity of depression and anxiety symptoms in elderly women.

In 2020, a decision was made at the Sorbian Institute to upgrade the dolnoserbski.de | niedersorbisch.de website with an additional section dedicated to the study of proper names in the Lower Sorbian language. Based on the former studies conducted at the Institute, the new section organises the onomastic material in a highly convenient, hypertextual form. Bearing in mind the multicultural context of the project, the Institute had to address several issues concerning, for example, the functional relationship between the Sorbian and German variants of a proper name, spelling standardisation (e.g. surnames), the lack of compatible word-formation processes, or a multilingual user interface. Additionally, the Institute intends to upgrade the resources of the section with exonyms and other types of onyms. However, due to the geopolitical conditions in Lusatia and the complicated nature of the relationship between the Lower Sorbian language with German and the Upper Sorbian language, this is a highly challenging task. Name research in the Lower Sorbian text corpus is also planned.

This study was designed to explore COVID-19 in a biopsychosocial model, taking into account the different mental and social consequences of the disease in women and men. A sociodemographic questionnaire containing anthropometric data, socioeconomic data, lifestyle data, health status before COVID-19, course of COVID-19, symptoms, and complications after COVID-19 was administered to 83 women and 64 men to investigate their mental health (MH) and quality of life (QoL). The Hospital Anxiety (HADS-A) and Depression (HADS-D) Scale, the Perceived Stress Scale (PSS-10) and the World Health Organization Quality of Life Scale Brief Version (WHOQOL-BREF) were adopted. Abnormal results in HADS-D and HADS-A were obtained in 33 (39.8%) women and 10 (15.6%) men and in 26 (31.3%) women and 14 (21.9%) men, respectively. Women experienced a lower level of QoL than men. The prolonged duration of COVID-19 symptoms was associated with increased anxiety in women during recovery. Good self-reported health before COVID-19 in women was associated with reduced QoL. Women had more symptoms of COVID-19 than men, and they experienced neurological complications more often. The presence of neurological complications in women appears to be associated with increased perceived anxiety and reduced QoL. This is an exploratory study whose results can influence future research with larger and more diverse samples.

Telerehabilitation (TR) seems to be an encouraging solution for the delivery of cognitive treatments in patients with neurological disorders. This study was aimed to analyze and synthesize the evidence on the efficacy of cognitive TR interventions in patients with neurological diseases, compared with conventional face-to-face rehabilitation. From a total of 4485 records, 9 studies met the inclusion criteria for qualitative analysis. At the end of the process, 7 studies remained for quantitative analysis. By comparing TR with face-to-face treatments for cognitive impairments, we assessed improvements in global cognitive domain (Mini Mental State Exam) (MD = −0.86; 95% CI −2.43, 0.72, I2 = 0%), in learning and memory domains (SMD = 0.26, 95% CI −0.22, 0.74, I2 = 24%), in verbal fluency (SMD = 0.08, 95% CI −0.47, 0.62, I2 = 0%), and in executive functions (i.e., problem-solving, central processing speed and working memory) (SMD = 0.38, 95% CI 0.06, 0.71, I2 = 0%). In all the included studies, improvement in the performance of the TR groups was comparable to that achieved through face-to-face intervention. Significant differences between those two modalities of providing treatments were observed for working memory and total executive function comparison, in favor of TR. The results of this study can sustain the efficacy of TR and its application for the treatment of neurological patients, especially when treated for executive function impairments.

Background: The complexity of health problems concerning women aged ≥60 years makes it necessary to develop effective, low-cost strategies involving biopsychosocial interventions. The aim of this study is to identify the factors associated with undertaking health-promoting activities by older women at high risk of metabolic syndrome (MetS) with or without depressive symptoms. Methods: The study group consisted of 70 older women (62–84 years old) undertaking regular physical activity. A self-developed questionnaire (used to determine the living situation, selected lifestyle components and health problems), the Perceived Stress Questionnaire (PSQ) and the Geriatric Depression Scale (GDS) were used. Results: In the study group undertaking regular physical activity, 40% had increased symptoms of depression (D group), and 60% were classified as non-depressed (ND group). The D group had a higher general stress level (t = −6.18, p = 0.001). Improving and/or maintaining physical fitness was identified as the greatest motivation in both groups. Willingness to spend time with other people significantly differed between the two groups (χ2 = 4.148, p = 0.042). The sole factor significantly differentiating between both groups was lack of time (χ2 = 8.777, p = 0.003). Conclusions: Motivations and barriers to undertaking health-promoting activities and levels of perceived stress were significantly different between the depressed and non-depressed groups. It is important to encourage primary care physicians to perform screening tests for late-life depression and to provide information on where therapeutic interventions are available for patients with symptoms of MetS and coexisting depressive symptoms.

As a common non-respiratory symptom of COVID-19, headache should not be overlooked, and its characteristics should be recorded with scrutiny. Identifying risk factors associated with post-COVID headache will ensure immediate action and counseling for this population of patients. Therefore, the study aimed to investigate the relationship between headache and psychological state (stress level, depression, and anxiety symptoms) in adults undergoing post-COVID-19 rehabilitation. In addition, we used mediation analysis to evaluate the mediation effect of psychological variables in the relationship between headache and quality of life. This cross-sectional study included 147 patients undergoing post-COVID-19 rehabilitation at the Public Hospital in Poland (64 males, 83 females, with mean age of 56.97 years). Psychological parameters were evaluated using the Hospital Anxiety and Depression Scale (HADS), the Perceived Stress Scale (PSS-10), and the brief World Health Organization Quality of Life Scale (WHOQOL-BRIEF). Additionally, all participants completed a questionnaire related to COVID-19 symptoms and their severity, the place of COVID-19 treatment, and the need for oxygen therapy during hospitalization. Of all participants, 65% experienced headache during COVID-19. Of the participants with headache, there were significantly more females in this group (69% vs. 31%), and they were significantly younger (mean age 55.47 vs. 59.78 years). Participants with headache had a 27% higher HADS-D score, a 21% higher HADS-A score, and a 13% higher PSS-10 score. Moreover, gender and headache were found to be important predictor variables for total HADS and HADS-D, accounting for 11% and 7%, respectively. Mediation analysis has shown that the tested psychological variables mediated 39–68% of the total effect of headache influence on WHOQOL domains. In conclusion, our study demonstrated several relationships between headache that occurred during COVID-19 and symptoms of depression, anxiety, and perceived stress level during post-COVID rehabilitation also in the context of quality of life. Our results show that patients who experienced headaches during COVID-19 are at high risk of developing anxiety-depressive symptoms later. Female gender is associated with a higher prevalence of headache during COVID-19.

BACKGROUND: Researchers suggest that physiotherapists are highly exposed to both the physical and the mental strains. OBJECTIVE: The aim of this study was to assess mood and the level of stress as well as a sense of coherence among future physiotherapists studying at the Department of Physiotherapy. METHODS: The study included 249 students, 181 women and 68 men. The Beck Depression Inventory (BDI), the Sense of Coherence Questionnaire (SOC-29) and the Perceived Stress Questionnaire (PSQ) were used. RESULTS: The examined group had an average level of sense of coherence and a low level of stress. One out of four students exhibited mood disorders. The factors associated with the prevalence of mood disorders among studied students were as follows: female (gender), lack of regular physical activity, poor financial situation, lack of friend to talk to in case of problems, dissatisfaction with the chosen field of study, and being inadequately prepared to work as a physiotherapist. CONCLUSIONS: The results of the study indicate an increased prevalence of mood disorders among students of physiotherapy. It is suggested that this situation may require the implementation of effective psychoprophylactic activities during the course of studies and broadly understood education about the psychophysical wellbeing of students, especially as they will work in an environment that requires high resistance to stress and support for other people in a crisis situation.

Pawel Kiper,1 Ewa Przysi&eogon;&zdot;na,2 B&lstrok;a&zdot;ej Cie&sacute;lik,1 Katarzyna Broniec-Siekaniec,3 Aleksandra Kuci&nacute;ska,3 Jaros&lstrok;aw Szczygie&lstrok;,4,5 Katarzyna Turek,6 Robert Gajda,7,8 Joanna Szczepa&nacute;ska-Gieracha2 1Healthcare Innovation Technology Lab, IRCCS San Camillo Hospital, Venezia, Italy; 2Faculty of Physiotherapy, University School of Physical Education in Wroclaw, Wroclaw, Poland; 3“REPTY” Upper Silesian Rehabilitation Centre, Tarnowskie Góry, Poland; 4Humanitas University in Sosnowiec, Sosnowiec, Poland; 5Neurorehabilitation Department, District Hospital, Zawiercie, Poland; 6The Karol Lipi&nacute;ski Academy of Music in Wroclaw, Wroc&lstrok;aw, Poland; 7Gajda-Med District Hospital in Pultusk, Pu&lstrok;tusk, Poland; 8Department of Kinesiology and Health Prevention, Jan Dlugosz University in Cz&eogon;stochowa, Cz&eogon;stochowa, PolandCorrespondence: Pawel Kiper, IRCCS San Camillo Hospital, Alberoni 70, Venezia, 30126, Italy, Tel +390412207157, Email pawel.kiper@hsancamillo.itPurpose: Depressive symptoms constitute an important group of mental problems that alter the course of post-stroke rehabilitation by reducing quality of life, physical activity, social functioning, and interpersonal relationships. Although several studies have shown the efficacy of virtual reality (VR) in the motor treatment of poststroke patients, there is a lack of studies that would also evaluate the impact of VR on psychological aspects. Thus, we investigated the effectiveness of immersive VR therapy on both functional activity and depressive symptoms in stroke survivors.Patients and Methods: We conducted a single blind, randomized controlled trial comparing VR therapy with Schultz’s Autogenic Training (SAT). Patients randomized to the VR group received treatment in an immersive VR therapeutic garden with elements of psychotherapy and physical activity of the upper extremities, whereas patients in the control group received SAT. Additionally, patients in both groups received standard neurological rehabilitation. The full research cycle lasted six weeks. We used Geriatric Depression Scale, Generalized Self-Efficacy Scale, Acceptance of Illness Scale, Visual Analogue Scale of pain, Hospital Anxiety and Depression Scale, Barthel Index, Lawton Instrumental Activities of Daily Living Scale and Rivermead Motor Assessment for outcome assessment. This trial was registered with ClinicalTrials.gov (NCT03830372).Results: We assessed 60 patients and randomly assigned to the VR or control group. The VR group showed a significant reduction in depressive symptoms (ηp2 = 0.13, p < 0.01) compared to SAT. The applied VR therapy significantly increased the sense of self-efficacy and the level of acceptance of the illness; however, this effect was similar to that obtained with the standard intervention. We did not observe statistically significant changes in the functional parameters of post-stroke patients.Conclusion: The use of VR therapy combined with neurological rehabilitation had a positive effect on improving mood and reducing depressive symptoms in post-stroke patients.Keywords: stroke, depressive symptoms, virtual reality, mental health, neurorehabilitation

Introduction Belief in one's personal capabilities are conducive to achieving success and provides additional energy for action. The stronger the conviction of one's self-efficacy, the higher the self-goals and the stronger the commitment to achieving them, despite any adversities. Our knowledge regarding the role of self-efficacy in post-stroke rehabilitation is still scarce. Aim of the Study The study aimed to analyze characteristics related to high self-efficacy levels before and after rehabilitation and to determine the role of self-efficacy in this process. Materials and Methods The study involved 99 stroke survivors. Participants' mental and functional state were assessed using Generalized Self-Efficacy Scale (GSES), Barthel Index (BI), Acceptance of Illness Scale (AIS), Geriatric Depression Scale (GDS), Visual Analogue Scale for Pain (VAS), Instrumental Activities of Daily Living (IADL) and Rivermead Mobility Index (RMI). Patients were evaluated twice: on admission (T1) and 3 weeks into rehabilitation (T2). Results Patients without self-efficacy improvement after 3 weeks of rehabilitation, on discharge from the ward demonstrated poorer well-being (p = 0.002, Hedges' g = 0.63, 95% CI [0.24-1.08]), lower illness acceptance levels (p < 0.001, Hedges' g = -0.78, 95% CI [-1.25 - -0.41]), poorer functional status in basic activities of daily living (p = 0.003, Hedges' g = -0.62, 95% CI [-1 - -0.25]), locomotive abilities (p = 0.004, Hedges' g = -0.58, 95% CI [-1.12 - -0.15]) and instrumental activities of daily living (p = 0.001, Hedges' g = -0.71, 95% CI [-1.15 - -0.34]). Conclusion Self-efficacy level is significantly related to rehabilitation outcomes. A routine self-efficacy assessment during the rehabilitation process seems very important. Patients whose initial self-efficacy is low or remains unchanged despite rehabilitation require special attention. Close cooperation between all members of the therapeutic team is essential to strengthen, at each stage, the sense of self-efficacy in stroke survivors.

The popularity of immersion, understood as absolute engrossment in a virtual world, has been growing year by year, due to new hi-tech sound, image and data-processing technologies. Man, because of human nature, is attracted to immersion as a way of experiencing new environments, which are often very different from those offered by the real world. Thanks to immersion in a virtual world, one can step into any desired computer-generated reality. This technology has found its use in the process of motor rehabilitation, likewise, psychological therapy. Total immersion in a virtual world creates the possibility for guided rehabilitation, utilising the appeal of am imaginary environment. Patients become more engaged and motivated to take part in the laborious and painstakingly long process leading to the recovery of their motor functions. Cooperation between physiotherapists and psychologists with engineers has resulted in the creation of new software solutions, and improved equipment, which can be tailored to meet the needs of patients with various mental problems or physical disfunctions and disabilities.

Every dialogue is constrained by a rigid framework, which manifests itself in its linear character (an initial-continuation-counter move structure or a question-answer relationship and dismissal-argumentation order of dialogue), and which illustrates the functional dependencies between sentences or sequences of sentences. The following study focuses on the discourse-pragmatic notion of the interviewer’s text-forming strategies, and, in particular, the question-answer relationship of political news interviews in Great Britain. Attention is focused on the questioning strategies employed by Andrew Marr in The Andrew Marr Show. Various types of questions within epistemic logic, which act as the strategic repertoire of the participants in dialogue games (Carlson 1983), are examined. The list of question types includes indirect and direct questions, where the former refer to sentential (yes-no), search (wh-questions), conditional, alternative, tag, ellipted, disjunctive or conjunctive questions (as instances of multiple questions), and the latter to questions presupposing the accomplishment of the specific epistemic state. Andrew Marr, as a dominant participant in this dialogue game, at least with reference to his role that presupposes topic control (selection and change of topics), will use this strategic weapon to influence the politicians’ performance and make them account for their political actions.

Vitamin C is an antioxidant that may scavenge reactive oxygen species preventing DNA damage and other effects important in cancer transformation. Dietary vitamin C from natural sources is taken with other compounds affecting its bioavailability and biological effects. High pharmacological doses of vitamin C may induce prooxidant effects, detrimental for cancer cells. An oxidized form of vitamin C, dehydroascorbate, is transported through glucose transporters, and cancer cells switch from oxidative phosphorylation to glycolysis in energy production so an excess of vitamin C may limit glucose transport and ATP production resulting in energetic crisis and cell death. Vitamin C may change the metabolomic and epigenetic profiles of cancer cells, and activation of ten-eleven translocation (TET) proteins and downregulation of pluripotency factors by the vitamin may eradicate cancer stem cells. Metastasis, the main reason of cancer-related deaths, requires breakage of anatomical barriers containing collagen, whose synthesis is promoted by vitamin C. Vitamin C induces degradation of hypoxia-inducible factor, HIF-1, essential for the survival of tumor cells in hypoxic conditions. Dietary vitamin C may stimulate the immune system through activation of NK and T cells and monocytes. Pharmacological doses of vitamin C may inhibit cancer transformation in several pathways, but further studies are needed to address both mechanistic and clinical aspects of this effect.

Breast cancer is becoming an important issue due to its various consequences and epidemiology. Studies are showing that it extremely impacts the mental health as well as the physical activity of the patients. In addition to the most common symptom, which is fatigue, patients also have problems with the quality of sleep. Therefore, this study aimed to evaluate the effectiveness of virtual reality (VR) therapy in improving the mental state and quality of sleep, as well as increasing the physical activity (PA) of patients diagnosed with breast cancer. The study was conducted in a hospital’s Breast Unit and included patients at the time of diagnosis of malignant breast cancer. A total of 16 subjects randomly divided into experimental (n = 9), and control (n = 7) groups were measured with the Beck Depression Scale, Mental Adjustment to Cancer Scale, International Physical Activity Questionnaire, and Pittsburgh Sleep Quality Index at two timepoints. The experimental intervention consisted of a 2-week (8 sessions) Virtual Therapeutic Garden (VRTierOne) procedure performed daily for about 15 min. Significant differences were identified between groups in the interactions between the main factors seen in the destructive style of the Mini-Mac scale: F(1.14) = 4.82, p = 0.04, and between multiple experiments: F(1.14)= 5.54, p = 0.03 showing a significant reduction in the destructive style of coping with the disease in the study group after therapy (32.44 vs. 28.33, p = 0.003). The level of main effects [study] for the constructive style is F(1.14) = 3.93, p = 0.06 with a significant increase in constructive style in the study group (43.33 vs. 45.33, p = 0.044). Significant differences in levels of depression between multiple experiments: F(1.14) = 5.04, p = 0.04, show a significant reduction in the severity of depressive symptoms was found in the experimental group after therapy (13.33 vs. 8.11, p = 0.02). However, the analysis did not show significant differences between group analyses (p = 0.25). It seems that VR reduces the severity of depressive symptoms and reduces the destructive style and can be an effective option in improving the mental state of patients diagnosed with breast cancer.

The study aims to determine the impact of multimodal therapeutic approach on self-perceived stress in women with high risk of Metabolic Syndrome (MetS). The study involved 43 women aged 60 years and over (mean 68.6 ± 6.5) participating in a Mental Health Promotion Program. Over the 3-month course of the project, all of the participants attended meetings of a support group (60-min sessions twice a week). During these meetings, they took part in general fitness training (20 min), dancing (20 min), as well as health-promoting education and psychoeducation sessions (20 min). Moreover, the participants were encouraged to modify their diet to reduce their daily fat and sugar intake. Stress levels were assessed using the Perception of Stress Questionnaire (PSQ). Mood was measured with the Geriatric Depression Scale (GDS-30). In all of the subjects, a body composition analysis was performed using a Tanita BC-545N analyzer. Abdomen and hip circumference were measured to determine the waist-hip ratio. Weight and height were measured to determine the BMI score. At the beginning of the project, the intensity of stress correlated with the level of depressive symptoms (GDS), Body Mass Index (BDI), and the amount of visceral fat. Three months of participation in the Mental Health Promotion Program resulted in a significant reduction in stress intensity (p &lt, 0.01). At the end of the project, all of the participants expressed their willingness to continue their participation in the classes, which is very important as there is a need to conduct long-term health-promoting activities in the age group in question.

Replication timing (RT) is a cellular program to coordinate initiation of DNA replication in all origins within the genome. RIF1 (replication timing regulatory factor 1) is a master regulator of RT in human cells. This role of RIF1 is associated with binding G4-quadruplexes and changes in 3D chromatin that may suppress origin activation over a long distance. Many effects of RIF1 in fork reactivation and DNA double-strand (DSB) repair (DSBR) are underlined by its interaction with TP53BP1 (tumor protein p53 binding protein). In G1, RIF1 acts antagonistically to BRCA1 (BRCA1 DNA repair associated), suppressing end resection and homologous recombination repair (HRR) and promoting non-homologous end joining (NHEJ), contributing to DSBR pathway choice. RIF1 is an important element of intra-S-checkpoints to recover damaged replication fork with the involvement of HRR. High-resolution microscopic studies show that RIF1 cooperates with TP53BP1 to preserve 3D structure and epigenetic markers of genomic loci disrupted by DSBs. Apart from TP53BP1, RIF1 interact with many other proteins, including proteins involved in DNA damage response, cell cycle regulation, and chromatin remodeling. As impaired RT, DSBR and fork reactivation are associated with genomic instability, a hallmark of malignant transformation, RIF1 has a diagnostic, prognostic, and therapeutic potential in cancer. Further studies may reveal other aspects of common regulation of RT, DSBR, and fork reactivation by RIF1.

Migraine, the leading cause of disability in the population aged below 50, is associated with functional gastrointestinal (GI) disorders (FGIDs) such as functional nausea, cyclic vomiting syndrome, and irritable bowel syndrome (IBS). Conversely, changes in intestinal GI transit may cause diarrhea or constipation and are a component of the autonomic symptoms associated with pre- and post-dorsal phases of migraine attack. These mutual relationships provoke a question on a common trigger in migraine and FGIDs. The kynurenine (l-kyn) pathway (KP) is the major route for l-tryptophan (l-Trp) metabolism and transforms l-Trp into several neuroactive compounds. Changes in KP were reported in both migraine and FGIDs. Migraine was largely untreatable, but several drugs approved lately by the FDA, including monoclonal antibodies for calcitonin gene-related peptide (CGRP) and its receptor, create a hope for a breakthrough in migraine treatment. Derivatives of l-kyn were efficient in pain relief with a mechanism including CGRP inhibition. KP products are important ligands to the aryl hydrocarbon receptor (AhR), whose activation is implicated in the pathogenesis of GI and migraine. Toll-like receptors (TLRs) may play a role in migraine and IBS pathogeneses, and KP metabolites detected downstream of TLR activation may be an IBS marker. The TLR4 signaling was observed in initiating and maintaining migraine-like behavior through myeloid differentiation primary response gene 88 (MyD88) in the mouse. The aim of this review is to justify the view that KP modulation may provide common triggers for migraine and FGIDs with the involvement of TLR, AhR, and MyD88 activation.

(1) Introduction: Neurologic music therapy (NMT) is a non-pharmacological approach of interaction through the therapeutic use of music in motor, sensory and cognitive dysfunctions caused by damage or diseases of the nervous system. (2) Objective: This study aimed to critically appraise the available literature on the application of particular NMT techniques in the rehabilitation of geriatric disorders. (3) Methods: PubMed, ScienceDirect and EBSCOhost databases were searched. We considered randomized controlled trials (RCTs) from the last 12 years using at least one of the NMT techniques from the sensorimotor, speech/language and cognitive domains in the therapy of patients over 60 years old and with psychogeriatric disorders. (4) Results: Of the 255 articles, 8 met the inclusion criteria. All papers in the final phase concerned the use of rhythmic auditory stimulation (RAS) (sensorimotor technique) in the rehabilitation of both Parkinson’s disease (PD) patients (six studies) and stroke patients (SPs) (two studies). (5) Conclusion: All reports suggest that the RAS technique has a significant effect on the improvement of gait parameters and the balance of PD patients and SPs, as well as the risk of falls in PD patients.

Objective The aim of this systematic review was to analyse the effectiveness of virtual reality intervention as an aid for treatment-related anxiety and fatigue in cancer patients undergoing chemotherapy. The term chemotherapy was assumed without distinction regarding type. Methods The inclusion criteria were (1) randomised controlled trials or crossover studies, (2) adult cancer patients undergoing chemotherapy, (3) treatment with VR scenarios providing distraction during chemotherapy, and (4) with pain, anxiety, fatigue, fear, or symptom distress as the measured outcomes. Articles in English, Polish, and Italian were sought. For the methodological quality assessment of risk of bias, likewise statistical analysis and meta-analysis the RevMan version 5.4 software and the Cochrane Risk of Bias Tool were used. Two authors independently analysed the following databases for relevant research articles: PubMed, Scopus, Cochrane Library, Web of Science, and Embase. Results From a total of 2543 records, 6 studies met the inclusion criteria for qualitative analysis. At the end of the process, 3 studies remained for quantitative analysis. The systematic review includes three randomised, controlled studies and three crossover studies with an overall sample size of 453 patients. The analysis of the primary outcomes chosen for each study revealed no significant differences between the control and experimental conditions. Moreover, an important factor influencing the results of the review and meta-analysis was the poor quality of the publications available on the topic of distraction during chemotherapy. Conclusion Due to the low research standards, the results do not provide an unambiguous answer to the research question. The most important limitations result from the small number of trials, the generally small sample sizes, and the differences in study design.

Raising and caring for children with disabilities involves a number of challenges that most parents/caregivers are unprepared for. Dealing with negative emotions such as guilt, lack of fulfillment, disappointed hopes, fear, shame and even despair can adversely affect the life of the entire family. Expressive suppression protects the ward and other family members from an outward expression of the caregiver’s emotions and prevents conflicts, but it does nothing to alleviate the caregiver’s internal emotional state. This study diagnoses the problem of expressive suppression in parents/caregivers of children with disabilities and assesses the connection between suppressed emotions and anxiety/depressive symptoms based on the Courtauld Emotional Control Scale (CECS) and the shortened Hamilton Depression Rating Scale (HAMD-7). The study involved 60 parents of children with disabilities living in metropolitan, urban, and rural areas. An elevated level of expressive suppression and the occurrence of anxiety-depressive disorders occurred in over half of the parents. Using non-parametric methods, a significant weak positive correlation (p = 0.398) is observed between the sum of the points obtained on the CECS scale and the sum of the points on the HAMD-7 scale. In the group with the elevated levels of expressive suppression, a significant strong positive correlation (p = 0.612) is observed between the sum of the points obtained on the CECS scale and the place of residence (with a higher degree of expressive suppression in parents from rural areas). There is also a significant correlation between the sum of points scored on the HAMD-7 scale and the financial standing of the families (p = 0.667), which reflects the impact of low social status on the occurrence of anxiety and depressive disorders.

Age-related macular degeneration (AMD), the main cause of vision loss in the elderly, is associated with oxidation in the retina cells promoting telomere attrition. Activation of telomerase was reported to improve macular functions in AMD patients. The catalytic subunit of human telomerase (hTERT) may directly interact with proteins important for senescence, DNA damage response, and autophagy, which are impaired in AMD. hTERT interaction with mTORC1 (mTOR (mechanistic target of rapamycin) complex 1) and PINK1 (PTEN-induced kinase 1) activates macroautophagy and mitophagy, respectively, and removes cellular debris accumulated over AMD progression. Ectopic expression of telomerase in retinal pigment epithelium (RPE) cells lengthened telomeres, reduced senescence, and extended their lifespan. These effects provide evidence for the potential of telomerase in AMD therapy. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) may be involved in AMD pathogenesis through decreasing oxidative stress and senescence, regulation of vascular endothelial growth factor (VEGF), and improving autophagy. PGC-1α and TERT form an inhibitory positive feedback loop. In conclusion, telomerase activation and its ectopic expression in RPE cells, as well as controlled clinical trials on the effects of telomerase activation in AMD patients, are justified and should be assisted by PGC-1α modulators to increase the therapeutic potential of telomerase in AMD.

Spheno-occipital synchondrosis (SOS) plays a significant role in the anterior growth of the midface. Orthopaedic forces acting during rapid maxillary expansion (RME) are transferred to the skull base and thus could alter the morphology of SOS. The aim of this study was to assess the influence of experimental RME on the rats’ SOS by means of micro-computed tomography (micro-CT). In all, 40 male 8‑week-old Wistar rats were enrolled into the study, among which 30 underwent experimental RME for 7, 14 and 21 days by means of custom designed spring-coil expander. Specimens were scanned by micro-CT and median palatal suture area, maxillary skeletal base and SOS width were analysed. Experimental RME resulted in a significant increase of the median palatal suture space and maxillary skeletal base which was particularly pronounced between day 14 and 21 of expansion. SOS width increased significantly during the first 7 days at the lowest point of the synchondrosis. However, the SOS width assessed at its highest point was temporarily even decreased between days 8 and 14 of therapy. Early SOS widening could be identified in the lowest part before median palatal suture opening. Similarly, narrowing of the SOS at its top was observed before the most significant median palatal suture expansion. Thus it can be hypothesized that changes within the SOS complex result from the transmission of the orthopaedic forces rather than from a displacement of the maxillary halves.