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O presente Relatório resulta do Estágio Curricular do Mestrado em Línguas e Relações Empresariais no Departamento Comercial da Bolseira – Embalagens S.A.. Tendo como propósito a apresentação da empresa, das atividades desenvolvidas e subsequentes reflexões, o Relatório contempla também um estudo de caso sobre o valor da comunicação no desenvolvimento de relações com os clientes e a importância atual e futura das línguas para a empresa. O estudo foi conceptualizado através de uma revisão da literatura e de entrevistas realizadas com a colaboração da Administração e de colaboradores da empresa. Ademais, apresentam-se os principais resultados e conclusões ao estudo, tais como sugestões de investigação futura. This paper results from the curricular internship for the Master's Degree in Languages and Business Relations in the Commercial Department of Bolseira - Embalagens S.A.. Its purpose is the presentation of the company, the activities developed and subsequent reflections. The paper also includes a case study on the value of communication in developing customer relationships and the current and future importance of languages to the company. This study was conceptualised through a literature review as well as interviews conducted with the cooperation of the company's Administration and employees. In addition, key findings and conclusions to the study are presented, as well as suggestions for future research. Mestrado em Línguas e Relações Empresariais

APOLO-Teens is a Facebook-based psychological intervention aiming to optimize hospital treatment for adolescents with overweight/obesity. The present qualitative study aims to explore (1) how adolescents experienced participation in APOLO-Teens and (2) how parents perceived adolescents' participation. Sixteen adolescent–parent dyads were interviewed by telephone using semistructured guides. An inductive approach of thematic analysis was used to analyze data by two independent codifiers. The consensus was used to resolve differences in coding/themes, and two independent auditors reviewed the codes and the themes proposed. We identified four themes from adolescents' interviews, namely, expectations, perception of outcomes, participation in the intervention, and sharing of acquired knowledge. From parents' interviews, we identified five themes: expectations for son/daughter participation, perception of adolescents' outcomes, son/daughter participation, parental role, and use of social networks in intervention programs for adolescents. Both elements of the dyad indicated that adolescents' participation in APOLO-Teens contributed to favorable outcomes, further highlighting the use of online interventions to complement the hospital treatment of adolescents with overweight/obesity. Future studies should address the viewpoints of adolescents and parents in the design of Facebook-based interventions, namely, to implement tailored, shorter, less time-demanding interventions that favor engagement between participants and parental involvement., Foundation for Science and Technology, Grant/Award Numbers: 2020.01538.CEECIND, 2020.07384.BD, PTDC/PSI-GER/28209/2017, SFRH/BD/146470/2019

Submitted by Margarida Vilhena Carvalho (mvc@ucp.pt) on 2021-09-13T16:51:27Z No. of bitstreams: 1 202750841.pdf: 693941 bytes, checksum: ba5b4eefcaef6e6d54058b5faf77b1c5 (MD5) Made available in DSpace on 2021-09-13T16:51:27Z (GMT). No. of bitstreams: 1 202750841.pdf: 693941 bytes, checksum: ba5b4eefcaef6e6d54058b5faf77b1c5 (MD5) Previous issue date: 2021-07-13

This study sought to determine the frequency of possible cases of avoidant/restrictive food intake disorder (ARFID) in a Portuguese sample of school-aged children and to assess the associations with child's internalizing problems, BMI z-score and body dissatisfaction, and parents' eating habits, attitudes and practices. We assessed 330 children through child's and parents'measures. Fifty-one (15.5%) children were possible cases of ARFID based on their symptom's presentation. There were no association between sex and possible cases of ARFID, and no significant differences between possible cases of ARFID and nonpossible cases of ARFID regarding age. Lower BMI z-score and anxiety/depression were associated with possible cases of ARFID., (undefined)

The most common mental problems are anxiety disorders, affecting today about 264 million people in the world. The reference treatments present limitations, such as their side effects and long intervention periods. Recently, various approaches have emerged, such as neurofeedback, virtual reality and serious games. Objective This study serves to determine preconditions and requirements for a game development, reusing virtual reality and neurofeedback to enhance the emotional self-regulation competences in individuals with anxiety disorders. Methods a scoping review was performed to identify the serious games' characteristics, resourcing to neurofeedback existent in this scope; and a focus group to ascertain the specialists' more relevant perspectives about preconditions and requirements integrating a game with these characteristics and objectives. Results/conclusion the scoping review results illustrate that the combined use of serious games, neurofeedback and virtual reality is still a very residual approach and without consolidated evidence, justifying the importance of further research. The specialists who formed the focus group emphasized, among others, the importance of gradual stimulation, co-creation and personalization of the developing resources.

Fungal infections and, in particular, those caused by species of the Candida genus, are growing at an alarming rate and have high associated rates of mortality and morbidity. These infections, generally referred as candidiasis, range from common superficial rushes caused by an overgrowth of the yeasts in mucosal surfaces to life-threatening disseminated mycoses. The success of currently used antifungal drugs to treat candidiasis is being endangered by the continuous emergence of resistant strains, specially among non-albicans Candida species. In this review article, the mechanisms of action of currently used antifungals, with emphasis on the mechanisms of resistance reported in clinical isolates, are reviewed. Novel approaches being taken to successfully inhibit growth of pathogenic Candida species, in particular those based on the exploration of natural or synthetic chemicals or on the activity of live probiotics, are also reviewed. It is expected that these novel approaches, either used alone or in combination with traditional antifungals, may contribute to foster the identification of novel anti-Candida therapies.

Purpose Grazing is a problematic eating behavior linked with poor weight loss outcomes, disordered eating psychopathology, and psychological distress in the adult population. However, no study assessed this behavior in children. Childhood is an important time frame for the development and maintenance of healthy eating habits, which can be influenced by children's psychological state, eating habits, and parental practices. This study investigates the associations between grazing behavior in children and children's psychological variables (anxiety, depression and withdrawn symptoms, body image dissatisfaction), children eating habits, and parental feeding practices. Methods In this cross-sectional study, 330 primary school students (6-10 years old) and their parents completed measures assessing children's grazing, anxiety/depression and withdrawn symptoms, body image dissatisfaction, children eating habits and style, and parental feeding practices. Results The path analysis tested showed that more restrictive parental feeding practices, inappropriate children eating habits, children's anxiety/depression symptoms, and body image dissatisfaction were associated with increased grazing scores (CMIN = 12.679; DF = 11; p = 0.315; RMSEA = 0.025; CFI = 0.990; NFI = 0.935; TLI = 0.982; IFI = 0.991; SRMR = 0.045). Conclusion Grazing tends to occur in a context of children's psychological distress, inappropriate children eating habits, and restrictive parental feeding practices. These variables should be addressed for the improvement of healthy eating habits and in weight-loss interventions for children., This study was partially conducted at Psychology Research Centre (PSI/01662), University of Minho, and supported by the Portuguese Foundation for Science and Technology and the Portuguese Ministry of Science, Technology and Higher Education through national funds, and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007653), by the following grants to Eva Conceicao (IF/01219/2014 and POCI-010145-FEDER-028209). The funding body had no role in the design, collection, analysis, and interpretation of data; the writing of the manuscript; or the decision to submit the manuscript for publication.

RAF kinase inhibitory protein (RKIP) is an important modulator of several signaling pathways, whose loss of expression has been observed in different human malignancies. In several studies, this decreased expression has been associated not only with the presence of metastasis, which leads to RKIP's identification as a metastasis suppressor gene, but also with tumor aggressiveness and poor prognosis. Importantly, RKIP has been reported to be involved in the modulation of cancer therapy response trough different mechanisms that sensitize cells to apoptosis. Given these findings, the usage of compounds capable of regulating RKIP expression emerged as a possible therapeutic approach to modulate therapy response and to control tumor aggressiveness. Herein, we will provide updated information about RKIP expression in different solid tumors and how it affects prognosis and response to therapy. Moreover, concerning therapy response we will present revised information about the compounds reported as being RKIP's modulators and the RKIP-dependent mechanisms, through which some of these compounds modulate drugs response.

Introduction The incidence of breast carcinoma (BC) has increased in the last years. Between 2 and 12% of patients diagnosed with BC will develop bilateral breast carcinoma (BBC). The treatment of these carcinomas is more aggressive than unilateral BC. Purpose To perform a retrospective qualitative analysis of BBC patients whose treatment has included brachytherapy (BT) and to present a revised literature on this issue. Material and methods The cases of BBC whose treatment included brachytherapy were revised. The literature on this issue was refreshed. Results Five women, aged between 54 and 78 at the time of the diagnosis, submitted to conservative surgery followed by external radiotherapy (RT) with boost of BT or exclusive BT (APBI), in the IPO-P BT Service between 2003 and 2016. Discussion The patients with BBC have slightly higher rates of local recurrences, mostly in the tumor bed, where there is a higher risk of local recurrence. Patients treated with BT had lower rates of recurrences than those treated with photons and electrons. Conclusions BBC represents a complex challenge for doctors, because in some cases there is a tendency to use more aggressive treatments and, at the same time, it is not easy to achieve the timing for the correct treatment.

Grazing is a problematic eating behavior linked with poor weight loss outcomes, disordered eating psychopathology, and psychological distress in the adult population. However, no study assessed this behavior in children. Childhood is an important time frame for the development and maintenance of healthy eating habits, which can be influenced by children's psychological state, eating habits, and parental practices. This study investigates the associations between grazing behavior in children and children's psychological variables (anxiety, depression and withdrawn symptoms, body image dissatisfaction), children eating habits, and parental feeding practices.In this cross-sectional study, 330 primary school students (6-10 years old) and their parents completed measures assessing children's grazing, anxiety/depression and withdrawn symptoms, body image dissatisfaction, children eating habits and style, and parental feeding practices.The path analysis tested showed that more restrictive parental feeding practices, inappropriate children eating habits, children's anxiety/depression symptoms, and body image dissatisfaction were associated with increased grazing scores (CMIN = 12.679; DF = 11; p = 0.315; RMSEA = 0.025; CFI = 0.990; NFI = 0.935; TLI = 0.982; IFI = 0.991; SRMR = 0.045).Grazing tends to occur in a context of children's psychological distress, inappropriate children eating habits, and restrictive parental feeding practices. These variables should be addressed for the improvement of healthy eating habits and in weight-loss interventions for children.Level V, cross-sectional descriptive study.

Oxytocin (OXT) has been used to prolong the luteal phase in mares, but its mechanism of action is unknown. The aim of this study was to evaluate the effect of chronic exogenous OXT administration to mid-luteal phase mares on luteal maintenance. Also, endometrial expression of prostaglandin endoperoxide synthase 2 (PTGS2), prostaglandin F2α, E2 and I2 synthases (AKR1C3, PTGES, and PTGIS), oxytocin receptor (OXTR), progesterone receptor (PGR), and estrogen receptors 1 (ESR1) and 2 (ESR2) were assessed in mares experiencing luteal maintenance 2 weeks after chronic exogenous OXT administration. Control mares (n = 5; C group) received 6 mL of saline im, whereas OXT (60 units/mare) was administered im (n = 6; OXT group), every 12 hours, on days 7 to 14 postovulation. After endometrial biopsy in groups C (Day 10) and OXT (Day 24), luteolysis occurred within 3 or 6 days, respectively. Luteal maintenance took place in 4 of 6 (67%) of OXT-treated mares. Progesterone in C group was the highest on biopsy day (P

Mestrado em Econometria Aplicada e Previsão O objetivo desta dissertação é quantificar o Value at Risk, calculado a partir de diferentes modelos econométricos GARCH e do modelo Risk Metrics, utilizando previsões da volatilidade a 1 passo, para as empresas Jerónimo Martins, SONAE, NOS e Pharol, presentes no Índice da Bolsa de Valores de Lisboa, de forma a verificar quando é que esta métrica foi ultrapassada pelas desvalorizações dos preços das ações das cotadas procurando destacar, neste trabalho, o "porquê" dos retornos serem de tal modo negativos que até ultrapassaram o VaR. A análise foca-se no período entre dezembro de 2012 e junho de 2017 e procura apresentar eventos que possam ter provocado tais perdas. The purpose of this dissertation is to quantify the Value at Risk, calculated from different GARCH econometric models and the Risk Metrics model, using one-step volatility forecasts, for the companies Jerónimo Martins, SONAE, NOS and Pharol, quoted in the Lisbon Stock Exchange Index, to verify when this metric has been exceeded by the devaluation of the listed company's shares prices. The analysis focuses on the period between December 2012 and June 2017 and seeks to present events that may have caused such losses. info:eu-repo/semantics/publishedVersion

Hypothalamic lesions can compromise its essential regulatory roles resulting in critical disruption of temperature and blood pressure homoeostasis. We present the case of a 55-year-old woman who had been previously submitted to several neurosurgical procedures aimed at treating idiopathic hydrocephalus. She presented to our department with recurring episodes of hypothermia and wide blood pressure variations, which had been worsening over the last few years. After extensive complementary workup, which excluded new neurological lesions or endocrinological conditions, hypothalamic dysfunction was assumed to be the cause of this syndrome. She was successfully treated with midodrine and on-demand captopril, which resulted in adequate control of her blood pressure. This case highlights the rare and unpredictable consequences of damage to the hypothalamus, depicting the favourable result of a heretofore unpublished medical approach.

A compactação uma das formas de melhoramento das propriedades dos solos, sendo de extrema importância estudar previamente as propriedades do solo que se pretende caracterizar para posteriormente recorrer-se ao tipo de compactação mais eficaz. Só assim é possível garantir a obtenção do máximo rendimento do solo. As características avaliadas são o teor em água e o peso específico, parâmetros obtidos através de ensaios de compactação, sendo o mais utilizado o ensaio de Proctor. No presente trabalho, são realizados outros tipos de ensaios de modo a relacioná-los com o tipo de solo em estudo. Para além dos ensaios de compactação, qualquer obra de terra (aterros, escavações, etc.) necessita que se conheçam os parâmetros de resistência do solo. Surgem, deste modo, os ensaios de caracterização mecânica que estimam qual a resistência do solo mediante um determinado esforço aplicado. A análise destes valores consoante o tipo de compactação realizada previamente revela qual é a capacidade resistente do solo dependendo do tipo de compactação efetuada. Deste modo, conhece-se qual o tipo de compactação que se deve aplicar para obter a resistência máxima do solo. A realização de ensaios laboratoriais requer tempo e pode ser oneroso se não existir um plano de ensaios devidamente implementado. Como primeira aproximação, são usualmente utilizadas relações empíricas que pode fornecer informações semelhantes aos ensaios laboratoriais, complementando assim os estudos e fornecendo algum grau de confiança aos inúmeros resultados laboratoriais. Na presente dissertação apresentam-se também estudos realizados com o objetivo de complementar investigações anteriormente promovidas, e assim desenvolver procedimentos adequados não só em trabalhos laboratoriais mas também de campo.

A artrite reumatoide é uma doença autoimune crónica caraterizada por sinovites extensas resultando na erosão da cartilagem articular e perda de osso marginal que levam à destruição da articulação. Indivíduos com artrite reumatoide têm tendência para um mau estado nutricional. Para além disso, alguns dos fármacos utilizados na sua terapêutica aumentam as necessidades de alguns nutrientes e, noutros casos, reduzem a sua absorção. Com este trabalho pretende-se fazer um resumo da informação científica disponível sobre o papel da alimentação e dos principais nutrientes mais indicados como complemento do tratamento da artrite reumatoide, nomeadamente na redução da sintomatologia, na progressão da doença e de efeitos secundários associados à toma dos fármacos recomendados. Apesar de já existir alguma evidência da utilidade da nutrição como complemento da terapêutica na artrite reumatoide, são necessários mais estudos para determinar as necessidades nutricionais ótimas para os indivíduos com artrite reumatoide, assim como comprovar os benefícios da suplementação nutricional específica. Rheumatoid arthritis is a chronic autoimmune disease characterized by extensive synovitis resulting in erosion of articular cartilage and marginal bone that lead to joint destruction. It’s common to patients with rheumatoid arthritis to have poor nutritional status. Furthermore, some of the drugs used in its treatment can increase the requirements of some nutrients in some cases or reduce their absorption in other cases. The objective of this paper is to review the scientific information of the importance of dietary patterns and the main nutrients recommended as complement for the treatment of rheumatoid arthritis in the reduction of symptomatology, the progression of the disease and the side effects associated to the drugs recommended. Although there is some evidence of the nutrition utility as complement of rheumatoid arthritis therapy, more studies are needed to determine the best nutritional needs in this disease, as well as to prove the benefits of nutritional supplements use.

Trabalho de Projecto apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Museologia O Projecto de Inventário do Património Religioso, imóvel e móvel, existente na Diocese da Guarda, em curso desde Fevereiro de 2007, foi encarado pelos seus promotores como sendo a génese de uma futura instituição museológica a criar na Diocese da Guarda. O enquadramento geográfico, histórico, eclesial e cultural do território pertencente à Diocese da Guarda, a análise aprofundada daquele Projecto de Inventário, as reflexões sobre a acção e posição da Igreja Católica em matéria de preservação e musealização do seu património religioso, bem como a observação de outras experiências de inventariação levadas a cabo por outras instituições eclesiásticas (Arquidiocese de Évora) foram fundamentais para apresentar linhas que contribuam para a definição da vocação e objectivos do novo Museu de história, arte e religião da Diocese da Guarda. As propostas programáticas que desenvolvo neste projecto de mestrado apontam no sentido da constituição de um Sistema Integrado para o Património Religioso (SIPR), que agregue aquele futuro museu, enquanto entidade coordenadora, as estruturas policêntricas (edifícios religiosos ao culto) e ainda as entidades de carácter museal, identificadas no diagnóstico, dispersas no território da Diocese da Guarda. Como âncora desse sistema, ao Museu de história, arte e religião da Diocese da Guarda competiriam funções de coordenação em matéria de preservação (incorporação; conservação e restauro; inventário e documentação), de investigação e de divulgação do património religioso in situ ou ex situ (em espaço museal), promovendo e dinamizando parcerias e acompanhando a vivência do património e as manifestações religiosas e culturais das comunidades no território da Diocese.

The process of evaluation and certification of school course books, as is stipulated by statutory law nº 47/2006 and regulated by the ruling nº 261/2007, hasn’t been studied before, as far as we are aware. In this way, this article synthesizes the masters’ investigatory work carried out in order to answer three questions: How is the new process of evaluation and certification carried out for school course books for Personal, social and health education? What importance do authors/publishers, evaluating entities and certifiers attribute to this process? What is the impact upon the quality of such course books from this evaluation and certification? The study is of a qualitative nature with the characteristics of an exploratory descriptive-interpretative one. For data collection two techniques were used: documental analysis and survey interviews. The documental analysis focused upon current legislation and on the final reports from the evaluation carried out by the scientific-learning teams; the interview, in a semisstructured form, was carried out upon authors and members of the scientific-leaning teams who made themselves available for contribution to this study. In relation to the results obtained it was noted that the final reports for text books in the curricular subject of Social Studies education at the Keystage 1 educational level revealed that these books were subject to a number of alterations (namely in linguistic, scientific, didactic learning and conceptual terms). With regard to the interviews with the evaluation process and outlining the many advantages or pros of said evaluations (in particular the rise in quality of school course books in terms of scientific quality and didactic learning), some faults were uncovered which should be subject to further consideration., El proceso de evaluación y certificación de manuales escolares (ME), tal como aparece encuadrado en la Ley n.º 47/2006 y reglamentado por el Despacho (Resolución) n.º 261/2007, no ha sido, por lo que se sabe, estudiado. De este modo, este artículo sintetiza el trabajo de investigación de Máster que pretendió dar respuesta a tres cuestiones: ¿Cómo se efectúa el nuevo proceso de evaluación y certificación de los ME de Conocimiento del Medio? ¿Qué importancia le atribuyen los autores/editores y entidades evaluadoras y certificadoras a este proceso? ¿Cuál es el impacto de la evaluación y certificación de los ME con respecto a su calidad? El estudio es de naturaleza cualitativa con características de estudio exploratorio descriptivo – interpretativo. Para la recogida de datos fueron utilizados dos técnicas: el análisis documental y la investigación por entrevistas. El análisis documental incidió en la legislación y en los informes finales de validación realizador por los equipos científico – pedagógicas; la entrevista, de tipo semiestructurada, fue efetuada a autores y miembros de los equipos científico- pedagógicas que se pusieron a disposición para contribuir en este estudio. Relativamente a los resultados obtenidos se verifico que los informes finales de evaluación de los manuales escolares del área curricular disciplinaria de estudio del 1er año del ciclo medio de escolaridad revelan que a estos manuales fueron propuestas modificaciones a varios niveles (sobre todo, lingüísticos, científicos, pedagógicos- didáticos y conceptuales), que nos dice con respecto a las entrevistas a los autores y miembros de los equipos científico - pedagógicas, a pesar de ser concordante con el proceso y apuntando diversos valores añadidos de este (particularmente a la mejoría de los manuales escolares en lo que concierne a su calidad científica y pedagógica - didática), evidencian algunas fallas que deben ser objeto de reflexión., O processo de avaliação e certificação de manuais escolares (ME), tal como enquadrado pela Lei n.º 47/2006 e regulamentado pelo Despacho nº261/2007, não foi, ao que se conhece, estudado. Deste modo, este artigo sintetiza o trabalho de investigação de mestrado que pretendeu dar resposta a três questões: Como se efetua o novo processo de avaliação e certificação dos ME de Estudo do Meio? Que importância os autores/editores e entidades avaliadoras e certificadoras atribuem a este processo? Qual o impacte da avaliação e certificação dos ME na sua qualidade científica a nível do conteúdo disciplinar e a nível didático-pedagógico? O estudo teve uma natureza metodológica predominantemente qualitativa com características de um estudo exploratório descritivo-interpretativo. Para a recolha de dados foram utilizadas duas técnicas: a compilação documental e o inquérito por entrevista. A compilação documental incidiu na legislação e nos relatórios finais de avaliação realizados pelas equipas científico-pedagógicas; a entrevista, do tipo semiestruturada, foi efetuada a autores e a membros das equipas científico-pedagógicas que se disponibilizaram a contribuir para este estudo. Relativamente aos resultados obtidos verificou-se que os relatórios finais de avaliação dos ME de Estudo do Meio do 1.º ano de escolaridade revelam que foram propostas alterações a vários níveis (nomeadamente, linguísticos, científicos, didático-pedagógicos e conceptuais) a todos os ME; no que diz respeito às entrevistas, apontam diversas mais-valias deste processo (particularmente a melhoria dos manuais escolares no que concerne à qualidade científica a nível do conteúdo disciplinar e a nível didático-pedagógico), porém evidenciam algumas falhas que devem ser objeto de reflexão.

Many women have incorrect notions of what they can eat during pregnancy and/or breast-feeding, due to preconceived ideas or myths related with the ingestion of some types of food. The aim of this study was to evaluate the alteration of food habits in pregnant women and identifying the myths related with eating habits in pregnant and breast-feeding women. A questionnaire of food habits alteration in pregnant women, the origin of the alterations and the reasons for such, as well as the eventual knowledge about which food interferes with pregnancy and/or breast-feeding and the Information about the alteration of weight during pregnancy and relevant clinical history were asked. The data were analysed though SPSS (Statistical Package for the Social Sciences), version13.0 for Windows. This study shows that although the majority of the alterations of food eating habits were done in a proper manner, there are still many inadequate or unnecessary food habit changes done in an empirical form, or based on myths, or indicated by some health professionals.

© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021, Bone is constantly being renewed: in the adult skeleton, bone resorption and formation are in a tightly coupled balance, allowing for a constant bone density to be maintained. Yet this micro-environment provides the necessary conditions for the growth and proliferation of tumor cells, and thus bone is a common site for the development of metastases, mainly from primary breast and prostate cancer. Mathematical and computational models with differential equations can replicate this bone remodeling process. These models have been extended to include the effects of disruptive tumor pathologies in the bone dynamics, as metastases contribute to the decoupling between bone resorption and formation and to the self-perpetuating tumor growth cycle. Such models may also contemplate the counteraction effects of currently used therapies, and, in the case of treatments with drugs, their pharmocokinetics and pharmacodynamics. We present a thorough overview of biochemical models for bone remodeling, in the presence of a tumour together with anti-cancer and anti-resorptive therapy, formulated as systems of first-order differential equations, or simplified using variable order derivatives. The latter models, of which some are new to this paper, result in equations with fewer parameters, and allow accounting for anomalous diffusion processes. In this way, more compact and parsimonious models, that promptly highlight tumorous bone interactions, are achieved, providing an effective framework to counteract the loss of bone integrity on the affected areas., This work was supported by FCT, through IDMEC, under LAETA, project UID/EMS/50022/2020, through INESC–ID, project UIDB/50021/2020, through project MONET, PTDC/CCI-BIO/4180/2020, and from the European Union’s Horizon 2020 research and innovation programme under grant agreement 951970.

O objetivo deste estudo foi realizar uma revisão de literatura integrativa sumariando toda a evidência científica, colhida dos artigos incluídos neste trabalho, que põem a hipótese de uma associação entre a Artrite reumatóide e a periodontite. Nesse âmbito foi utilizado como motor de busca a MEDLINE usando a combinação dos seguintes termos: Rheumatoid arthritis, periodontal disease, periodontitis e Porphyromonas gingivalis. A pesquisa identificou 1233 artigos, dos quais 21 foram considerados relevantes para este estudo. Esses estudos revelaram que os doentes com periodontite e artrite reumatóide registaram níveis mais elevados de anticorpos anti-Porphyromonas gingivalis comparativamente ao grupo controlo. Estes doentes estariam associados a maior taxa de atividade inflamatória da doença e teriam maiores títulos de anticorpos fator reumatóide e anticorpos anti-proteína citrulinada no sangue periférico. Em suma, a Porphyromonas gingivalis exerce um papel notável no aparecimento clínico da artrite reumatóide, visto que pode modular os anticorpos anti-proteína citrulinada. No entanto, mais estudos serão necessários para esclarecer cabalmente esta interação.