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This article belongs to the Special Issue Environmental Microbiology: Perspectives for Medicine and Public Health. Beach sand may act as a reservoir for numerous microorganisms, including enteric pathogens. Several of these pathogens originate in human or animal feces, which may pose a public health risk. In August 2019, high levels of fecal indicator bacteria (FIB) were detected in the sand of the Azorean beach Prainha, Terceira Island, Portugal. Remediation measures were promptly implemented, including sand removal and the spraying of chlorine to restore the sand quality. To determine the source of the fecal contamination, during the first campaign, supratidal sand samples were collected from several sites along the beach, followed by microbial source tracking (MST) analyses of Bacteroides marker genes for five animal species, including humans. Some of the sampling sites revealed the presence of marker genes from dogs, seagulls, and ruminants. Making use of the information on biological sources originating partially from dogs, the municipality enforced restrictive measures for dog-walking at the beach. Subsequent sampling campaigns detected low FIB contamination due to the mitigation and remediation measures that were undertaken. This is the first case study where the MST approach was used to determine the contamination sources in the supratidal sand of a coastal beach. Our results show that MST can be an essential tool to determine sources of fecal contamination in the sand. This study shows the importance of holistic management of beaches that should go beyond water quality monitoring for FIB, putting forth evidence for beach sand monitoring. Financial support came from CESAM (UID/AMB/50017-POCI-01-0145-FEDER-007638) and CITAB (UID/AGR/04033/2019), via FCT/MCTES, from national funds (PIDDAC), cofounded by FEDER (PT2020 Partnership Agreement and Compete 2020) info:eu-repo/semantics/publishedVersion

Beach sand may act as a reservoir for numerous micro-organisms, including enteric pathogens. Several of these pathogens originate in human or animal feces, which may pose a public health risk. In August 2019, high levels of fecal indicator bacteria (FIB) were detected in the sand of the Azorean beach Prainha, Terceira Island, Portugal. Remediation measures were promptly implemented, including sand removal and the spraying of chlorine to restore the beach sand quality. To determine the biological source of the contamination, during the first campaign, supratidal sand samples were collected from several sites along the beach, followed by microbial source tracking (MST) analyses of Bacteroides markers for five animal species, including humans. Some of the sampling sites revealed the presence of marker genes from dogs, seagulls, and ruminants. Making use of the information on biological sources originating partially from dogs, the municipality enforced restrictive measures for dog-walking at the beach. Subsequent sampling campaigns detected low FIB contamination due to the mitigation and remediation measures that were undertaken, thereby no longer requiring MST marker-gene analysis. This is the first case study where the MST approach was used to determine the contamination sources in the supratidal sand of a coastal beach. Our results show that MST can be an essential approach to determine sources of fecal contamination in the sand. This study shows the importance of holistic management of beaches that should go beyond water quality monitoring for FIB, putting forth evidence for the need for sands also to be monitored.

Dissertação de mestrado em Comunicação Multimédia Exame público realizado em 7 de dezembro de 2022 A dissertação desenvolvida como parte não lectiva do Mestrado em Comunicação e Multimédia consiste num projecto de evento cultural focado no cinema experimental multimédia, denominado Alquimia. Este é desenvolvido em torno de dois objetivos: o primeiro, relacionado com a produção cinematográfica de discurso experimental no panorama mediático actual em que a imagem digital, a produção de conteúdos transmídia e as ligações através de rede de banda larga se constituem como bases técnicas das vanguardas actuais. Para este efeito, parte-se da hipótese que para que seja executada uma cartografia do cinema de discurso experimental na atualidade devemos focar a nossa atenção na técnica e tecnologia que temos disponíveis e que são previsíveis existir a breve trecho, e estudar de que forma podem ser utilizadas para fazer evoluir o discurso experimental no cinema. O segundo objectivo prende-se com a necessidade de lidar com a constante mudança que existe nesta área, sendo por isso necessário fazer-se uma actualização regular das possibilidades que as inovações técnicas permitem tendo por isso levado a cabo a organização de um festival-residência artística com a duração de dois dias que teve lugar no concelho de Vendas Novas, tendo por base organizacional uma fusão dos conceitos de festival de cinema, com os princípios de LANs Parties,Game Jams, residências artísticas, e Demoscene.

Observed chemical species in the Venusian mesosphere show local-time variabilities. SO2 at the cloud top exhibits two local maxima over local time, H2O at the cloud top is uniformly distributed, and CO in the upper atmosphere shows a statistical difference between the two terminators. In this study, we investigated these local-time variabilities using a three-dimensional (3D) general circulation model (GCM) in combination with a two-dimensional (2D) chemical transport model (CTM). Our simulation results agree with the observed local-time patterns of SO2, H2O, and CO. The two-maximum pattern of SO2 at the cloud top is caused by the superposition of the semidiurnal thermal tide and the retrograde superrotating zonal (RSZ) flow. SO2 above 85 km shows a large day-night difference resulting from both photochemistry and the sub-solar to anti-solar (SS-AS) circulation. The transition from the RSZ flows to SS-AS circulation can explain the CO difference between two terminators and the displacement of the CO local-time maximum with respect to the anti-solar point. H2O is long-lived and exhibits very uniform distribution over space. We also present the local-time variations of HCl, ClO, OCS and SO simulated by our model and compare to the sparse observations of these species. This study highlights the importance of multidimensional CTMs for understanding the interaction between chemistry and dynamics in the Venusian mesosphere., Comment: 51 pages, 19 figures, accepted by Planetary Science Journal

Submitted by António Freitas (amsf@uma.pt) on 2021-11-23T11:57:09Z No. of bitstreams: 1 FranciscoTeixeira_dissertacao_final.pdf: 3662289 bytes, checksum: 357f1df2c0beb690422c7ec1f864fd77 (MD5) Made available in DSpace on 2021-11-23T11:57:09Z (GMT). No. of bitstreams: 1 FranciscoTeixeira_dissertacao_final.pdf: 3662289 bytes, checksum: 357f1df2c0beb690422c7ec1f864fd77 (MD5) Previous issue date: 2021-07-27

The Alzheimer’s Amyloid Precursor Protein (APP), a central protein in Alzheimer´s Disease (AD), is metabolized in a highly complex fashion by a series of sequential secretases, which can lead to α, β, and γ-cleavage, accordingly. The toxic abilities of the resulting fragments are a direct consequence of the first cleaving secretase: β-secretase (BACE1) induces an amyloid cleavage while, α-secretase (ADAM10 and ADAM17) cleavage does not have the same pathological impact in AD. The latter is currently being studied as a therapeutic target for preventing or reverting the initial biochemical events of AD, as it may compete with BACE1 for APP’s first cleavage. Literature demonstrates that retinoic acid (RA) receptor (RAR) alters secretase activity, suggesting anti-amyloid effects: downregulation of Amyloid-β-peptide (Aβ) releasing secretases (β and γ-secretase) and upregulation of the beneficial α-secretase. In addition, RA reduces neuroinflammation and promotes neurite growth. To experimentally verify the impact of RA, the SH-SY5Y neuronal cell line was used. Differentiated cells were treated for 48 hours with retinoids agonists and antagonists for different RAR isoforms. Treatments suggest alterations in proteins directly associated with AD, that can be either benefitial or pathlogical, depending the RAR isoform being stimulated. The APP secretaseome was compiled and analyzed. The data from a YTH system was introduced and new potential interactors described. Targets from a holistic and systems aproach were identified as potencial interest proteins for further understanding the impact of stimulating each RAR isoform. Data from mass spectophotometry analysis of the insoluble fraction of human fibroblasts from AD patients was also introduced in the search for targets in the holistic and systems medicine perspective. Coincidentelly, some targets were found in common when compared with the APP secretase network, being possible important proteins in the context of AD neurodegeneration pathways. In conclusion, bioinformatic approaches provide global and dynamic results on molecular changes and interactions under different conditions, of particular interest for complex pathologies such as AD. Induced therapeutic changes must restore homeostasis and not only alter the specific source of the problem. The combination of bioinformatics and wet lab tools provides a putative gateway, with promising results in the specific study of effects resulting from the stimulattion of the retinoid acid receptor as a potential therapy for AD. A proteína precursora da Doença de Alzheimer (APP), uma proteína central na Doença de Alzheimer (AD), é metabolizada de forma altamente complexa por uma série de secretases, que podem levar às clivagens α, β e γ. As capacidades tóxicas dos fragmentos resultantes são uma consequência direta da primeira clivagem: a β-secretase (BACE1) induz uma clivagem amiloide enquanto, contrariamente, a clivagem da α-secretase (ADAM10 e ADAM17) não tem o mesmo impacto patológico na AD. As α-secretases são, há algum tempo, alvo de estudo como um potencial alvo terapêutico para prevenir ou reverter os eventos bioquímicos iniciais da AD, uma vez que podem competir com BACE1 pela primeira clivagem de APP. A literatura demonstra que o recetor (RAR) do ácido retinoico (RA) altera a atividade das secretases, promovendo efeitos anti amiloides: regulação negativa do peptídeo β-amiloide (Aβ), libertado pelas secretases β e γ, e regulação positiva da α-secretase. Além disso, o RA reduz a neuroinflamação e promove o crescimento de neurites. Para verificar experimentalmente o impacto do RA, a linha de células neuronal SH-SY5Y foi usada. As células foram diferenciadas e tratadas durante 48 horas com retinoides agonistas e antagonistas de diferentes isoformas do RAR. O tratamento sugere alterações nas proteínas diretamente associadas à AD, que podem ser benéficas ou patológicas, dependendo da isoforma do RAR estimulada. Posteriormente, o secretaseoma da APP foi obtido e analisado. Dados experimentais obtidos por técnicas de dupla hibridação em leveduras foram incorporados potenciando novos interactores. Os alvos, a partir de uma abordagem holística e sistémica, foram identificados como proteínas de potencial interesse para a melhor perceção do impacto da estimulação dos RAR e da diferença decorrente de cada uma de suas isoformas individuais. Dados da análise de espectrofotometria de massa da fração insolúvel de fibroblastos humanos com AD também foram introduzidos na pesquisa por alvos do ponto de vista holístico e de medicina de sistemas. Coincidentemente, alguns alvos encontram-se em comum quando comparados com a rede de secretases da APP apresentando-se como possíveis pontos de importante valor no contexto das vias de neurodegeneração da AD. Em conclusão, as abordagens bioinformáticas fornecem resultados globais e dinâmicos sobre mudanças moleculares e interações proteicas sob diferentes condições, de particular interesse para patologias complexas como a AD. As alterações terapêuticas induzidas devem ser compatíveis com a homeostase e não apenas alterar a origem específica do problema. A combinação de bioinformática e ferramentas de wet lab fornecem uma potencial forma de abordagem para patologias complexas, com resultados promissores no estudo específico dos efeitos resultantes da estimulação dos RAR como uma potencial terapia na AD. Mestrado em Biomedicina Molecular

Tese de mestrado em Bioquímica, Universidade de Lisboa, Faculdade de Ciências, 2021 Submitted by Cristina Manessiez (camanessiez@fc.ul.pt) on 2021-05-04T18:03:02Z No. of bitstreams: 1 ulfc126202_tm_João_Luz.pdf: 1375547 bytes, checksum: f9c2d311d8bdbf84fb39c5eb227c3ffb (MD5) Made available in DSpace on 2021-05-04T18:03:15Z (GMT). No. of bitstreams: 1 ulfc126202_tm_João_Luz.pdf: 1375547 bytes, checksum: f9c2d311d8bdbf84fb39c5eb227c3ffb (MD5) Previous issue date: 2021

To evaluate the postoperative results of patients with supination-external rotation ankle fractures who underwent syndesmotic screw (SS) removal.Retrospective cohort study assessing the late postoperative results of 35 patients operated from January 2013 to June 2015. Patients undergoing treatment of rupture of the distal tibiofibular syndesmosis with SS fixation and who did not have any concomitant surgical injuries in sites other than the ankle were included. Patients who did not complete appropriate follow-up after surgery were excluded from the study.There was no statistical significant difference in the evaluated outcomes among the patients who had their SS removed and those who remained with the SS.SS removal did not significantly alter the clinical results of patients surgically treated with SS for supination-external rotation fractures.Avaliar o resultado pós-operatório dos pacientes com fratura do tornozelo pelo mecanismo de supinação-rotação externa que foram submetidos a retirada do parafuso transindesmoidal (PT).Estudo de coorte retrospectivo que avaliou os resultados pós-operatórios tardios de 35 pacientes operados entre janeiro de 2013 e junho de 2015. Foram incluídos pacientes submetidos ao tratamento da ruptura da sindesmose tibiofibular distal com fixação com PT e que não apresentavam lesões cirúrgicas concomitantes em outros sítios que não o tornozelo. Pacientes que não foram devidamente acompanhados no pós-operatório foram excluídos.Não houve diferença estatisticamente significativa nos desfechos avaliados entre os pacientes que tiveram o PT removido e os que permaneceram com o PT.A retirada do PT não alterou significativamente o resultado clínico dos pacientes tratados cirurgicamente com PT por fraturas do tipo supinação-rotação externa.

OBJECTIVE: To evaluate the clinical results of surgical treatment of intraarticular fractures of the calcaneus, comparing the use of calcaneal plate and flat plate. METHODS: This was a retrospective study assessing the postoperative results of 25 patients between 2013 and 2015. Patients undergoing surgical treatment of intraarticular fractures of the calcaneus without concomitant surgical lesions were included. Patients who did not complete appropriate follow-up after surgery were excluded from the study. RESULTS: The unavailability of calcaneal plates at resource-limited settings, associated with the availability and lower cost of flat plates, may have been a confounding factor in the present study. However, there was no statistical difference between the outcomes of fractures treated with calcaneal plates or flat plates. CONCLUSION: Statistical inference shows that, when calcaneal plates are not available, it is possible to use flat plates with similar clinical outcomes. RESUMO OBJETIVO: Avaliar os resultados clínicos do tratamento cirúrgico das fraturas intra-articulares do calcâneo (TCFIAC) e comparar o uso de placa própria para calcâneo (PPC) e placa reta (PR) . MÉTODOS: Estudo retrospectivo que avaliou o resultado pós-operatório de 25 pacientes entre 2013 e 2015. Foram incluídos pacientes submetidos ao TCFIAC e que não apresentavam lesões cirúrgicas concomitantes. Pacientes que não foram devidamente acompanhados no pós-operatório foram excluídos da análise. RESULTADOS: A indisponibilidade da PPC em serviços com recursos limitados, associada à disponibilidade e ao menor custo da PR, pode ter sido fator de confusão no presente estudo. Contudo, não houve diferença estatística entre os resultados das fraturas tratadas com PPC ou PR. CONCLUSÃO: A inferência estatística permite concluir que, na ausência da PPC, é possível usar a PR com desfechos clínicos semelhantes.

Resumo Nas últimas décadas, a pesquisa em Ensino de Ciências tem evidenciado a relevância do papel desempenhado pela História da Ciência no ensino e aprendizagem das mesmas. É tão importante aprender ciências como aprender sobre ciências e esta compreensão sobre o que é a ciência envolve tanto reconhecer a sua inserção num contexto social, como também ter uma ideia de como é construído o conhecimento científico e de que forma este se diferencia dos saberes do quotidiano. A metodologia de Ensino Baseado em Casos (EBC), rompeu décadas de ensino meramente transmissivo e enquadra-se na perspetiva socioconstrutivista da aprendizagem, onde o professor é mediador e os alunos trabalham em grupos e aprendem com os seus colegas. Esta metodologia de ensino parece assim vantajosa, uma vez que os alunos desenvolvem habilidades de trabalho colaborativo e resolução de problemas, além de dotar os alunos com âncoras mentais para os fatos, conceitos e princípios a serem estudados e assimilados. Reconhecendo a potencialidade desta metodologia de ensino e a faculdade da HC no ensino das ciências, foi proposto um caso que espelha a história do avanço científico e tecnológico dos pacemakers cardíacos. O estudo, ainda em desenvolvimento, irá incidir numa amostra de conveniência (n=26) constituída por alunos do 9o ano de escolaridade de uma escola pública de uma zona urbana do norte do país. Palavras-chave: História da Ciência; ensino baseado em casos; pacemakers cardíacosAbstract In recent decades, research in science education has highlighted the importance of the role played by HC in teaching and learning. As Matthews (1995), is so important to learn how to learn science as to learn science. This understanding of the Science involves both recognize the insertion in a social context, your as well as get an idea of how scientific knowledge is constructed and how this differs from knowledge of everyday life. The case-based teaching methodology broke decades of teaching merely transmissive and fits on social constructivism theory perspective of learning, where the teacher is a mediator and the students work in groups and learn from their colleagues. This teaching methodology seems so advantageous, since students develop job skills and collaborative problem-solving, in addition to providing students with mental anchors for the facts, concepts and principles to be studied and assimilated. Recognizing the potential of this methodology of teaching and the power of HC in science teaching, it was proposed a case that mirrors the history of scientific and technological advancement of pacemakers. This study, still under development, will focus on a convenience sample (n=26) consisting of students from the 9th grade level of a public school in an urban area in the north of the country. Keywords: history of science; case-based teaching; pacemakers.

To evaluate the clinical results of surgical treatment of intraarticular fractures of the calcaneus, comparing the use of calcaneal plate and flat plate.This was a retrospective study assessing the postoperative results of 25 patients between 2013 and 2015. Patients undergoing surgical treatment of intraarticular fractures of the calcaneus without concomitant surgical lesions were included. Patients who did not complete appropriate follow-up after surgery were excluded from the study.The unavailability of calcaneal plates at resource-limited settings, associated with the availability and lower cost of flat plates, may have been a confounding factor in the present study. However, there was no statistical difference between the outcomes of fractures treated with calcaneal plates or flat plates.Statistical inference shows that, when calcaneal plates are not available, it is possible to use flat plates with similar clinical outcomes.Avaliar os resultados clínicos do tratamento cirúrgico das fraturas intra-articulares do calcâneo (TCFIAC) e comparar o uso de placa própria para calcâneo (PPC) e placa reta (PR).Estudo retrospectivo que avaliou o resultado pós-operatório de 25 pacientes entre 2013 e 2015. Foram incluídos pacientes submetidos ao TCFIAC e que não apresentavam lesões cirúrgicas concomitantes. Pacientes que não foram devidamente acompanhados no pós-operatório foram excluídos da análise.A indisponibilidade da PPC em serviços com recursos limitados, associada à disponibilidade e ao menor custo da PR, pode ter sido fator de confusão no presente estudo. Contudo, não houve diferença estatística entre os resultados das fraturas tratadas com PPC ou PR.A inferência estatística permite concluir que, na ausência da PPC, é possível usar a PR com desfechos clínicos semelhantes.

Resumo Objetivo Avaliar o resultado pos‐operatorio dos pacientes com fratura do tornozelo pelo mecanismo de supinacao‐rotacao externa que foram submetidos a retirada do parafuso transindesmoidal (PT). Metodos Estudo de coorte retrospectivo que avaliou os resultados pos‐operatorios tardios de 35 pacientes operados entre janeiro de 2013 e junho de 2015. Foram incluidos pacientes submetidos ao tratamento da ruptura da sindesmose tibiofibular distal com fixacao com PT e que nao apresentavam lesoes cirurgicas concomitantes em outros sitios que nao o tornozelo. Pacientes que nao foram devidamente acompanhados no pos‐operatorio foram excluidos. Resultados Nao houve diferenca estatisticamente significativa nos desfechos avaliados entre os pacientes que tiveram o PT removido e os que permaneceram com o PT. Conclusao A retirada do PT nao alterou significativamente o resultado clinico dos pacientes tratados cirurgicamente com PT por fraturas do tipo supinacao‐rotacao externa.

Introduction: This study aimed to explore the views and attitudes of Chinese psychiatrists on mental disorders classification, and to compare their similarities and differences with those of the international mental health professionals. Methods: Two hundred and ninety members of the Chinese Society of Psychiatry were invited to participate in the study and 211 completed the survey. Results: Ninety-one percent of Chinese participants regularly used a formal classification system, with more users of the International Classification of Diseases 10th Revision (ICD-10; 48.8%) or Chinese Classification of Mental Disorders 3rd Edition (39.3%) than the 4th Edition of Diagnostic and Statistical Manual (11.4%). Like their global counterparts, Chinese respondents regarded communication among clinicians as the most important purpose of a classification and preferred a simpler system with fewer categories. Chinese psychiatrists were more likely than international participants to prefer a system with strict diagnostic criteria for all disorders and to endorse problems with a cultural applicability of the classification. However, only a minority (31.3%) indicated that they saw a need for a national classification. Discussion: Overall, Chinese psychiatrists have similar opinions and attitudes on most issues of the classification to the international clinicians. Areas of divergent views may provide meaningful information for ICD revision in China.

Dissertação de mestrado em Psicologia (Psicologia da Educação, Desenvolvimento e Aconselhamento), apresentada à Faculdade de Psicologia e de Ciências da Educação da Universidade de Coimbra. O presente estudo exploratório teve como intuito analisar a possível relação entre o desenvolvimento do autoconceito e de comportamentos antissociais em crianças e adolescentes, uma vez que, estes são constructos que desempenham um papel significativo na formação dos indivíduos ao longo da vida. Os dados de estudo foram recolhidos em escolas públicas, junto de uma amostra de 187 sujeitos (99 rapazes) com idades compreendidas entre os 7 e 13 anos de idade e uma média de idades de 9 anos. Nesta investigação foram utilizados os seguintes instrumentos de avaliação: para recolher alguma informação contextual pertinente à análise em causa (idade, ano de escolaridade, género, nível socioeconómico, etc.), foi administrado um “Questionário Sócio-demográfico”; de seguida, para avaliar o autoconceito recorreu-se à escala “Piers-Harris Children’s Self-Concept Scale” (PHCSCS-2) de Piers & Herzberg (2002), com adaptação à população portuguesa por Feliciano Veiga (2006); e por último, para avaliar os comportamentos antissociais utilizou-se a escala“Self-Reported Antisocial Behavior scale” (SRA), originalmente elaborada por Loeber e colaboradores (1989), versão portuguesa experimental de Fonseca com estudo factorial de Cavadas (2010). Quantos aos resultados apresentados, verificou-se uma baixa prevalência de comportamentos antissociais na amostra de estudo, todavia, ficou comprovado que existia uma relação negativa reduzida entre este tipo de comportamentos e o autoconceito. Os resultados obtidos também apontaram para a existência de diferenças significativas nos comportamentos antissociais e alguns indicadores sócio-demográficos (idade, género, nível socioeconómico, etc.), o mesmo não se verificando em relação ao autoconceito. This exploratory study was meant to examine the possible relationship between the development of self-concept and antisocial behaviors in children and adolescents, since these are constructs that play a significant role in the formation of individuals throughout life. The study data was collected at public schools on a sample of 187 subjects (99 boys) aged between 7 and 13 years and a mean age of 9 years. In this investigation the following assessment instruments were used: to gather some background information relevant to the analysis (age, grade, gender, socioeconomic status, etc.), a “Socio-demographic Questionnaire” was issued; then to assess the self-concept, the scale "Piers-Harris Children's Self-Concept Scale" (PHCSCS-2) Piers & Herzberg (2002), with adaptation to the Portuguese population by Feliciano Veiga (2006), was applied; and lastly, the scale "Self-Reported Antisocial Behavior scale" (SRA), originally developed by Loeber and colleagues (1989), experimental Portuguese version of Fonseca with factorial study of Cavadas (2010), was used to assess the antisocial behavior. As to the results presented, there was a low prevalence of antisocial behaviors in the study sample, however, it was concluded that there was a small negative relationship between this type of behavior and self-concept. The results also pointed to the existence of significant differences in antisocial behavior considering some socio-demographic variables (age, gender, socioeconomic status, etc.), the same was not observed in respect to self-concept

The development of automated measurement systems for monitoring basic functional geometries arises as a response to the increasing automation of manufacture. The paper describes the optimization of the grid increment to be used in the algorithm established by the authors to automatically recognize 3D geometries. Differential geometry was used to determine Gaussian and mean local curvatures of surfaces described by ordered cloud point representation, considered the fundamental conditions for the decision of geometric shapes automatic identification. A case study for spherical surfaces is shown, relating the grid increment with the values of the sphere attributes. The optimization of the increment appears to minimize the uncertainty of the algorithm. The results validated the suitability of the algorithm hereby proposed.

Phase equilibrium data for the systems carbon dioxide/ethyl acetate and carbon dioxide/isoamyl acetate at the temperatures of 295.2, 303.2 and 313.2 K, and for pressures up to the critical point, is given. The experimental results are correlated by the Soave–Redlich–Kwong and Peng–Robinson equations of state, and the associated interaction parameters reported.

A practical e-training development approach can facilitate and promote the development of competencies and knowledge in industry. This paper presents a training strategy and a common methodology for building training courses with the purpose to provide an efficient inter-organizational approach to industrial training development. The methodology for building e-training courses proposes to create training materials in an easier way, enabling various organizations to actively participate on its production. The result is an approach able to facilitate intra and inter enterprises knowledge creation and transfer.Copyright © 2013 by ASME

To examine the conceptualizations held by psychiatrists and psychologists around the world of the relationships among mental disorders in order to inform decisions about the structure of the classification of mental and behavioral disorders in World Health Organization's International Classification of Diseases and Related Health Problems 11th Revision (ICD-11).517 mental health professionals in 8 countries sorted 60 cards containing the names of mental disorders into groups of similar disorders, and then formed a hierarchical structure by aggregating and disaggregating these groupings. Distance matrices were created from the sorting data and used in cluster and correlation analyses.Clinicians' taxonomies were rational, interpretable, and extremely stable across countries, diagnostic system used, and profession. Clinicians' consensus classification structure was different from ICD-10 and the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV), but in many respects consistent with ICD-11 proposals.The clinical utility of the ICD-11 may be improved by making its structure more compatible with the common conceptual organization of mental disorders observed across diverse global clinicians.

In the current globalized and competitive business world it has become increasingly more important that companies adapt their knowledge bases, in order to establish more dynamic business partnerships. However, one of the main problems found in the establishment of such partnerships has to do with the lack of interoperability between technologic systems, especially those related to the semantic of shared knowledge. The integration and sharing of the knowledge representation elements of companies, performs a key role in the research challenges in the business interoperability area. The paper presents a methodology to analyse the economic viability of companies in the needed effort to the conception of a common knowledge base in their operational domain area, in order to stimulate interoperability in the business cooperation. These studies also have as objective to support the development of the thesis that argues that in the future, the capability to adapt the semantics of business information systems will promote collaboration between companies, providing them new business opportunities.

Manufacturing teams face the challenge of integration and reuse of computational information systems and knowledge. Ontologies constitute a set of concepts, axioms and relationships describing a domain of interest. The distributed and heterogeneous nature of the organizations, in particular networked enterprises, led to the development of different ontologies for the same or overlapping areas, resulting in non-interoperability. This has become the basis for research methodologies to support a reference ontology, contributing to the standardization and development of ontologies within enterprises and virtual network, providing interoperability properties to intelligent systems. This paper extends the MENTOR methodology to support the development of reference ontology in the field of metrology. The aim is to maintain the different ontologies of each partner, providing networked enterprises with coherent interaction and unambiguous communication. A case study in the field of metrology is presented and the proposed methodology is demonstrated.

O trabalho que a seguir se apresenta tem como objectivo descrever a criação de um modelo que sirva de suporte a um sistema de apoio à decisão sobre o risco inerente à execução de projectos na área das Tecnologias de Informação (TI) recorrendo a técnicas de mineração de dados. Durante o ciclo de vida de um projecto, existem inúmeros factores que contribuem para o seu sucesso ou insucesso. A responsabilidade de monitorizar, antever e mitigar esses factores recai sobre o Gestor de Projecto. A gestão de projectos é uma tarefa difícil e dispendiosa, consome muitos recursos, depende de numerosas variáveis e, muitas vezes, até da própria experiência do Gestor de Projecto. Ao ser confrontado com as previsões de duração e de esforço para a execução de uma determinada tarefa, o Gestor de Projecto, exceptuando a sua percepção e intuição pessoal, não tem um modo objectivo de medir a plausibilidade dos valores que lhe são apresentados pelo eventual executor da tarefa. As referidas previsões são fundamentais para a organização, pois sobre elas são tomadas as decisões de planeamento global estratégico corporativo, de execução, de adiamento, de cancelamento, de adjudicação, de renegociação de âmbito, de adjudicação externa, entre outros. Esta propensão para o desvio, quando detectada numa fase inicial, pode ajudar a gerir melhor o risco associado à Gestão de Projectos. O sucesso de cada projecto terminado foi qualificado tendo em conta a ponderação de três factores: o desvio ao orçamentado, o desvio ao planeado e o desvio ao especificado. Analisando os projectos decorridos, e correlacionando alguns dos seus atributos com o seu grau de sucesso o modelo classifica, qualitativamente, um novo projecto quanto ao seu risco. Neste contexto o risco representa o grau de afastamento do projecto ao sucesso. Recorrendo a algoritmos de mineração de dados, tais como, árvores de classificação e redes neuronais, descreve-se o desenvolvimento de um modelo que suporta um sistema de apoio à decisão baseado na classificação de novos projectos. Os modelos são o resultado de um extensivo conjunto de testes de validação onde se procuram e refinam os indicadores que melhor caracterizam os atributos de um projecto e que mais influenciam o risco. Como suporte tecnológico para o desenvolvimento e teste foi utilizada a ferramenta Weka 3. Uma boa utilização do modelo proposto possibilitará a criação de planos de contingência mais detalhados e uma gestão mais próxima para projectos que apresentem uma maior propensão para o risco. Assim, o resultado final pretende constituir mais uma ferramenta à disposição do Gestor de Projecto. The aim of this work is to create a model that sustains a decision support system which determines the inherent risk of the execution of projects in the Information Technologiescontext. During the life cycle of a project, there are a number of factors that contribute to its success or failure. The responsibility of monitoring, predicting and mitigating these factors belongs to the Project Manager. The management of projects is a hard and expensive task, it consumes many resources and depends on many variables and, frequently, even on the experience of its own Project Manager. When confronted with the estimate of duration and effort for the execution of a specific task, the Project Manager doesn´t have, except for his own perception and personal intuition, an objective way to measure the plausibility of the values which are presented by the task executor. These predictions are paramount for the organization, because many strategic decisions, concerning projects, are base on them. Decisions such as: global planning, execution, postponement, cancellation, outsourcing, scope renegotiation, etc. This tendency for deviation, when detected at an initial stage, may help to better manage the risk of Project Management. The success of each completed project was calculated taking into account the weighting of three factors: was it on time, on budget and within client specification. After analyzing all closed projects, and correlating some of its attributes with the degree of success, the model classifies, qualitatively, a new project for risk. In this context the risk is the degree of deviation from the project to success. Using data mining algorithms, such as classification trees and neural networks, this report describes the development of a model that supports a Decision Support System for theclassification of new projects for risk. The models are the result of an extensive set of tests toseek validation and refine the indicators that best characterize a project and that most influence the risk. As technological support for developing and testing the tool was used Weka 3. A good use of the proposed model will enable the creation of more detailed contingency plans and closer management for projects with a greater propensity for risk. The final result of this project aims to be one more tool which the Project Manager can have at his disposal. A good use of the proposed model will imply the creation of more detailed contingency plans and a closer management for projects that have a larger tendency for risk.

O autor ousou apresentar a teologia de São Cirilo a partir dos conceitos da comunicação. Mostrou que São Cirilo de Jerusalém criou um estilo simbólico e gestual de criar o conteúdo da Palavra de Deus a partir do espaço sagrado e, simultaneamente, possibilitou aos seus ouvintes o sonho do imaginário religioso como mapa da realidade a ser seguido. Assim, logrou ressignificar a comunicação como mistagogia, que quer dizer conduzir o interlocutor a uma “virtualização do corpo” como experiência de uma linguagem que, mais do que texto, produz um estilo de vida que refaz o aprendizado segundo o tempo e os espaços possíveis, mergulhado no Mistério de Deus.

Dissertação apresentada à Escola Superior de Educação de Lisboa para obtenção do grau de Mestre em Intervenção Precoce O presente estudo exploratório teve como objetivo comparar os comportamentos interativos maternos e paternos, em crianças de 15 meses. Os comportamentos diádicos são os alicerces da qualidade da relação entre os pais e a criança, e estas relações precoces são determinantes para a organização da personalidade e para o desenvolvimento da criança. Nesse sentido, pretendemos descrever os comportamentos diádicos detalhadamente e em seguida categorizá-los no intuito comparar os modos (tipo de jogo usado, respostas verbais, tipo de contato físico) e as funções (qualidade da comunicação) da interação mãe-filho(a) e pai-filho(a). A amostra foi constituída por 10 díades com bebés de termo e sem condições assinaláveis de risco (5 meninos e 5 meninas). As díades foram filmadas em situação de jogo livre, mãe-filho(a) e pai-filho(a) independentemente. As interações foram transcritas, segundo o método de narrativas, que constituíram o suporte de trabalho. Construímos uma grelha de análise, para uma síntese quantitativa, e posteriormente procedeu-se ao estudo qualitativo das interações verbais. Os resultados do nosso trabalho apontam para a existência de caraterísticas diferentes nas interações dos pais e das mães quando brincam com os seus filhos, sendo as de maior relevo: a) as mães utilizam mais a linguagem verbal que os pais; b) os pais utilizam mais a linguagem não verbal que as mães; c) as mães têm uma comunicação não verbal mais expressiva; d) as mães têm tendência a estruturar o ambiente de jogo; e) os pais têm tendência para dar instruções verbais sobre o funcionamento dos brinquedos. Os modos das interações tendem a ser diferentes, mas as funções que elas cumprem atingem os mesmos objetivos, que são a qualidade da comunicação pais-filhos. A sensibilidade materna tem sido largamente estudada em suas caraterísticas. Este trabalho permite indagar se a comunicação não verbal dos pais, pelo efeito positivo que encontramos nas interações com os filho(a)s, será uma especificidade da sensibilidade paterna. Sabendo que as perturbações da vinculação foram incluídas como critério de inclusão na Intervenção Precoce, julgamos que o nosso trabalho oferece à intervenção e à investigação um a descrição microanalística dos comportamentos e das trocas diádicas entre pais e filhos podendo, deste modo, ser mais um aporte para a promoção de relações seguras. ABSTRACT The present exploratory study wants to compare the maternal and paternal interactive behaviours with 15 months old children. The dyadic behaviours are the foundations for a good maternal/paternal relationship to the child, and these early relationships are crucial to the formation and development of the child’s personality. In this sense, we intend to describe this behaviours in detail and then categorize them expecting to compare the methods (games used, verbal answers, physical contact) and the functions (communication’s quality) of parent-child interaction. The sample consisted of 10 dyads, with babies born at term, with no special conditions of risk (5 boys and 5 girls). All the dyads were videotaped in free play situation, mother-child (a) and father-child (a) independently. The interactions were transcribed according to the method of narratives, which were the work support. We built an analytical grid, for a quantitative synthesis, and subsequently proceeded to the qualitative study of verbal interactions. The results of our study point to the existence of different characteristics between the interactions of fathers and mothers when playing with their children. From all, the most evident tell us that: a) mothers use more verbal language than fathers; b) fathers use more non verbal language than mothers; c) the non verbal communication of mothers is more expressive; d) mothers tend to structure the game environments; e) and fathers tend to give verbal instructions about the way toys work. The interactions’ methods tend to be distinct, but the functions that they serve do fulfill the same goals, which are the quality of parents-children communication. Maternal sensitivity has been largely studied in its characteristics. However, the present study allows considering if non verbal communication of fathers, through the positive effect we encounter in their interactions with their children, is a specificity of the fatherhood sensitivity. Knowing that the disturbances of bonding were included as a criterion of inclusion in the Early Intervention, we think that our work provides to the intervention and to the research a microanalysis’ description of the behaviours and dyads’ exchanges between parents and children, and, thus, it may be a contribution to promote safe relations.

The formation of cooperation and collaboration alliances between several small organizations is proving, in multiple cases, to be more efficient and competitive by comparison with big companies. Manufacturing processes span nowadays across borders as result of the globalization markets pressure, thus research on manufacturing management has turned from an intra-enterprise to an inter-enterprise focus. Consequently there is a growing interest in electronic business (e-business) solutions to facilitate information sharing between organizations in the supply chain. However, due to the worldwide diversity of communities, a high number of knowledge representation elements, such as ontologies, which are not semantically coincident, have appeared representing the same segment of reality. Even operating in the same domain, enterprises do not understand each other, making the communication among various systems parties more difficult and sometimes impracticable. As a result there is a demand for intelligent solutions capable of reinforcing partnerships and collaborations between enterprises, which needs to be able to manage its maintenance dynamically. Authors propose the increase of Interoperability in the mechanical manufacturing domain by the use of a knowledge–based methodology able to build a reference ontology and to provide its maintenance through the system user’s feedback.Copyright © 2011 by ASME