Search

Your search keyword '"Jo, Young-Rae"' showing total 24 results
Start Over Author "Jo, Young-Rae"
24 results on '"Jo, Young-Rae"'

16. Potential neuron‐autonomous Purkinje cell degeneration by 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase promoter/Cre‐mediated autophagy impairments

Author

Jo, Young Rae, primary, Kim, Hye Ran, additional, Jang, So Young, additional, Go, Hana, additional, Song, Min‐Young, additional, Park, Da Kyeong, additional, Oh, Yuna, additional, Jo, Juyeon, additional, Shin, Yoon Kyung, additional, Lee, Sung Joong, additional, Cheon, Sang‐Myung, additional, Lee, Hyun Kyoung, additional, Lee, Kyung Eun, additional, Kim, Young Hye, additional, and Park, Hwan Tae, additional

Published
2020
Full Text
View/download PDF

17. Serum CXCL13 reflects local B-cell mediated inflammatory demyelinating peripheral neuropathy

Author

Kim, Younghee, primary, Jang, So Young Jang, additional, Shin, Yoon Kyung, additional, Jo, Young Rae, additional, Yoon, Byeol-A, additional, Kim, Nam Jun, additional, Nam, Soo Hyun, additional, Choi, Byung-Ok, additional, Shin, Ha Young, additional, Kim, Seung Woo, additional, Kim, Se Hoon, additional, Kim, Jong Kuk, additional, and Tae, Park Hwan, additional

Published
2019
Full Text
View/download PDF

20. p75 and neural cell adhesion molecule 1 can identify pathologic Schwann cells in peripheral neuropathies

Author

Kim, Young Hee, primary, Kim, Young Hye, additional, Shin, Yoon Kyung, additional, Jo, Young Rae, additional, Park, Da Kyeong, additional, Song, Min‐Young, additional, Yoon, Byeol‐A., additional, Nam, Soo Hyun, additional, Kim, Jong Hyun, additional, Choi, Byung‐Ok, additional, Shin, Ha Young, additional, Kim, Seung Woo, additional, Kim, Se Hoon, additional, Hong, Young Bin, additional, Kim, Jong Kuk, additional, and Park, Hwan Tae, additional

Published
2019
Full Text
View/download PDF

21. Potential neuron‐autonomous Purkinje cell degeneration by 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase promoter/Cre‐mediated autophagy impairments.

Author

Jo, Young Rae, Kim, Hye Ran, Jang, So Young, Go, Hana, Song, Min‐Young, Park, Da Kyeong, Oh, Yuna, Jo, Juyeon, Shin, Yoon Kyung, Lee, Sung Joong, Cheon, Sang‐Myung, Lee, Hyun Kyoung, Lee, Kyung Eun, Kim, Young Hye, and Park, Hwan Tae

Abstract

Studies of neuroglial interaction largely depend on cell‐specific gene knockout (KO) experiments using Cre recombinase. However, genes known as glial‐specific genes have recently been reported to be expressed in neuroglial stem cells, leading to the possibility that a glia‐specific Cre driver results in unwanted gene deletion in neurons, which may affect sound interpretation. 2′,3′‐Cyclic nucleotide 3′‐phosphodiesterase (CNP) is generally considered to be an oligodendrocyte (OL) marker. Accordingly, Cnp promoter‐controlled Cre recombinase has been used to create OL‐specific gene targeting mice. However, in this study, using Rosa26‐tdTomato‐reporter/Cnp‐Cre mice, we found that many forebrain neurons and cerebellar Purkinje neurons belong to the lineages of Cnp‐expressing neuroglial stem cells. To answer whether gene targeting by Cnp‐Cre can induce neuron‐autonomous defects, we conditionally deleted an essential autophagy gene, Atg7, in Cnp‐Cre mice. The Cnp‐Cre‐mediated Atg7 KO mice showed extensive p62 inclusion in neurons, including cerebellar Purkinje neurons with extensive neurodegeneration. Furthermore, neuronal areas showing p62 inclusion in Cnp‐Cre‐mediated Atg7 KO mice overlapped with the neuronal lineage of Cnp‐expressing neuroglial stem cells. Moreover, Cnp‐Cre‐mediated Atg7‐KO mice did not develop critical defects in myelination. Our results demonstrate that a large population of central neurons are derived from Cnp‐expressing neuroglial stem cells; thus, conditional gene targeting using the Cnp promoter, which is known to be OL‐specific, can induce neuron‐autonomous phenotypes. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

24. Protective activity of a novel resveratrol analogue, HS-1793, against DNA damage in 137Cs-irradiated CHO-K1 cells

Author

Jeong, Min Ho, Yang, Kwang Mo, Jeong, Dong Hyeok, Lee, Chang Geun, Oh, Su Jung, Jeong, Soo Kyung, Lee, Ki Won, Jo, Young Rae, and Jo, Wol Soon

Abstract

Resveratrol has received considerable attention as a polyphenol with anti-oxidant, anti-carcinogenic, and anti-inflammatory effects. Radiation is an important component of therapy for a wide range of malignant conditions. However, it causes damage to normal cells and, hence, can result in adverse side effects. This study was conducted to examine whether HS-1793, a novel resveratrol analogue free from the restriction of metabolic instability and the high dose requirement of resveratrol, induces a protective effect against radiation-induced DNA damage. HS-1793 effectively scavenged free radicals and inhibited radiation-induced plasmid DNA strand breaks in an in vitro assay. HS-1793 significantly decreased reactive oxygen species and cellular DNA damage in 2 Gy-irradiated Chinese hamster ovary (CHO)-K1 cells. In addition, HS-1793 dose-dependently reduced the levels of phosphorylated H2AX in irradiated CHO-K1 cells. These results indicate that HS-1793 has chemical radioprotective activity. Glutathione levels and superoxide dismutase activity in irradiated CHO-K1 cells increased significantly following HS-1793 treatment. The enhanced biological anti-oxidant activity and chemical radioprotective activity of HS-1793 maintained survival of irradiated CHO-K1 cells in a clonogenic assay. Therefore, HS-1793 may be of value as a radioprotector to protect healthy tissue surrounding tumor cells during radiotherapy to obtain better tumor control with a higher dose.

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results