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19 results on '"Jo, Seong Jun"'

3. Assessment of the clinical pharmacokinetic interaction potential mediated So-Cheong-Ryong-Tang on a cocktail of anti-inflammatory and anti-biotic drugs, established by physiologically based pharmacokinetic modelings

Author

Kim, Da Hyun, primary, Lee, Chae Bin, additional, Chin, Sabin, additional, Lee, Sangyoung, additional, Jo, Seong Jun, additional, Chae, Soon Uk, additional, Kim, Duk Yeon, additional, Jerng, Ui Min, additional, and Bae, Soo Kyung, additional

Published
2024
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11. A Sensitive, Simple, and Fast LC–MS/MS Method for Quantification of Remifentanil in Human Plasma: Applications in Critically Ill Patients' Plasma during Extracorporeal Membrane Oxygenation.

Author

Chae, Soon Uk, Kim, Ji Seon, Lee, Chae Bin, Jo, Seong Jun, Min, Kyung Lok, Chang, Min Jung, and Bae, Soo Kyung

Subjects
LIQUID chromatography-mass spectrometry, EXTRACORPOREAL membrane oxygenation, ELECTROSPRAY ionization mass spectrometry, REMIFENTANIL, CRITICALLY ill, MATRIX effect
Abstract

A sensitive, simple, and fast liquid chromatography–tandem mass spectrometry (LC–MS/MS) bioanalytical method was developed to determine remifentanil in human plasma and prevent its instability by esterases during quantification. A 20 μL sample of human plasma, acidified with formic acid, was precipitated using 100 μL of acetonitrile. Chromatography was carried out on an Agilent Poroshell 120 EC-C18 column (4.6 × 50 mm, 2.7 μm) with an isocratic elution by acetonitrile and distilled water containing 0.1% formic acid (65:35, v/v) at a flow rate of 0.5 mL/min. Transition ions were detected as m/z 377.10→113.20 and m/z 277.00→111.00 for remifentanil and chlorpropamide (internal standard), respectively, with positive electrospray ionization in mass spectrometry. The run time was only 3 min per sample. We evaluated the selectivity, linearity, carry-over, accuracy, precision, extraction recovery, absolute matrix effect, stability, and incurred sample reanalysis and found that all these parameters were within acceptable limits. The calibration curve range for remifentanil was 0.05–50 ng/mL with regression coefficient (r) values higher than 0.9939. Given the simple and fast sample preparation and the lower LLOQ concentration compared to those in other methods, this method was successfully used to quantify plasma levels after intravenous infusion of remifentanil to intensive-care-unit patients during extracorporeal membrane oxygenation. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 Is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone

Author

Zheng, Yu Fen, primary, Bae, Soo Hyeon, additional, Huang, Zhouchi, additional, Chae, Soon Uk, additional, Jo, Seong Jun, additional, Shim, Hyung Joon, additional, Lee, Chae Bin, additional, Kim, Doyun, additional, Yoo, Hunseung, additional, and Bae, Soo Kyung, additional

Published
2020
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19. Nano-Fe 3 O 4 /Carbon Nanotubes Composites by One-Pot Microwave Solvothermal Method for Supercapacitor Applications.

Author

Park, Sul Ki, Sure, Jagadeesh, Vishnu, D. Sri Maha, Jo, Seong Jun, Lee, Woo Cheol, Ahmad, Ibrahim A., Kim, Hyun-Kyung, and Shabani, Bahman

Subjects
NANOTUBES, ENERGY density, CARBON nanotubes, MICROWAVES, MAGNETITE, CHEMICAL stability
Abstract

Carbon nanotubes (CNTs) are being increasingly studied as electrode materials for supercapacitors (SCs) due to their high electronic conductivity and chemical and mechanical stability. However, their energy density and specific capacitance have not reached the commercial stage due to their electrostatic charge storage system via a non-faradic mechanism. Moreover, magnetite (Fe3O4) exhibits higher specific capacitance originating from its pseudocapacitive behaviour, while it has irreversible volume expansion during cycling. Therefore, a very interesting and facile strategy to arrive at better performance and stability is to integrate CNTs and Fe3O4. In this study, we demonstrate the microwave-solvothermal process for the synthesis of Fe3O4 nanoparticles uniformly grown on a CNT composite as an electrode for SCs. The synthesized Fe3O4/CNT composite delivers a reversible capacitance of 187.1 F/g at 1 A/g, superior rate capability by maintaining 61.6% of 10 A/g (vs. 1 A/g), and cycling stability of 80.2% after 1000 cycles at 1 A/g. [ABSTRACT FROM AUTHOR]

Published
2021
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