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1. Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study

Author

Hafizi, Hasan, Aliko, Anila, Bardhi, Donika, Tafa, Holta, Thanasi, Natasha, Mezini, Arian, Teferici, Alma, Todri, Dafina, Nikolla, Jolanda, Kazasi, Rezarta, Cherkaski, Hamid Hacene, Bengrait, Amira, Haddad, Tabarek, Zgaoula, Ibtissem, Ghit, Maamar, Roubhia, Abdelhamid, Boudra, Soumaya, Atoui, Feryal, Yakoubi, Randa, Benali, Rachid, Bencheikh, Abdelghani, Ait-Khaled, Nadia, Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Studnicka, Michael, Dawes, Torkil, Lamprecht, Bernd, Schirhofer, Lea, Islam, Akramul, Ahmed, Syed Masud, Islam, Shayla, Islam, Qazi Shafayetul, Mesbah-Ul-Haque, Chowdhury, Tridib Roy, Chatterjee, Sukantha Kumar, Mia, Dulal, Chandra Das, Shyamal, Rahman, Mizanur, Islam, Nazrul, Uddin, Shahaz, Islam, Nurul, Khatun, Luiza, Parvin, Monira, Khan, Abdul Awal, Islam, Maidul, Lawin, Herve, Kpangon, Arsene, Kpossou, Karl, Agodokpessi, Gildas, Ayelo, Paul, Fayomi, Benjamin, Mbatchou, Bertrand, Ashu, Atongno Humphrey, Tan, Wan C., Wang, Wen, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jin-ping, Zhou, Yumin, Jogi, Rain, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Adegnika, Ayola Akim, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, SchwedaLinow, Alexandra, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jorundsdottir, Kristin, Lovisa Gudmundsdottir, Gudmundsdottir, Sigrun, Gudmundsson, Gunnar, Rao, Mahesh, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Juvekar, Sanjay, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Salvi, Sundeep, Brashier, Bill, Londhe, Jyoti, Madas, Sapna, Aquart-Stewart, Althea, Aikman, Akosua Francia, Sooronbaev, Talant M., Estebesova, Bermet M., Akmatalieva, Meerim, Usenbaeva, Saadat, Kydyrova, Jypara, Bostonova, Eliza, Sheraliev, Ulan, Marajapov, Nuridin, Toktogulova, Nurgul, Emilov, Berik, Azilova, Toktogul, Beishekeeva, Gulnara, Dononbaeva, Nasyikat, Tabyshova, Aijamal, Mortimer, Kevin, Nyapigoti, Wezzie, Mwangoka, Ernest, Kambwili, Mayamiko, Chipeta, Martha, Banda, Gloria, Mkandawire, Suzgo, Banda, Justice, Loh, Li-Cher, Rashid, Abdul, Sholehah, Siti, Benjelloun, Mohamed C., Nejjari, Chakib, Elbiaze, Mohamed, El Rhazi, Karima, Wouters, E.F.M., Wesseling, G.J., Obaseki, Daniel, Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Gulsvik, Amund, Endresen, Tina, Svendsen, Lene, Nafees, Asaad A., Irfan, Muhammad, Fatmi, Zafar, Zahidie, Aysha, Shaukat, Natasha, Iqbal, Meesha, Idolor, Luisito F., de Guia, Teresita S., Francisco, Norberto A., Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Jr., Reyes, Maria Teresita N., Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Garcia, Gerard S., Naval, Sullian S., Reyes, Thessa, Roa, Camilo C., Jr., Sanchez, Flordeliza, Simpao, Leander P., Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Mejza, Filip, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Barbara, Cristina, Rodrigues, Fatima, Dias, Herminia, Cardoso, Joao, Almeida, João, Matos, Maria Joao, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Al Ghobain, M., Alorainy, H., El-Hamad, E., Al Hajjaj, M., Hashi, A., Dela, R., Fanuncio, R., Doloriel, E., Marciano, I., Safia, L., Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gunasekera, Kirthi, Wickremasinghe, Rajitha, Elsony, Asma, Elsadig, Hana A., Osman, Nada Bakery, Noory, Bandar Salah, Mohamed, Monjda Awad, Akasha Ahmed Osman, Hasab Alrasoul, Moham ed Elhassan, Namarig, El Zain, Abdel Mu’is, Mohamaden, Marwa Mohamed, Khalifa, Suhaiba, Elhadi, Mahmoud, Hassan, Mohand, Abdelmonam, Dalia, Janson, Christer, Olafsdottir, Inga Sif, Nisser, Katarina, SpetzNystrom, Ulrike, Hagg, Gunilla, Lund, GunMarie, Seemungal, Terence, Lutchmansingh, Fallon, Conyette, Liane, Harrabi, Imed, Denguezli, Myriam, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Kocabas, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Burney, Peter G.J., Gnatiuc, Louisa, Azar, Hadia, Patel, Jaymini, Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Dudhaiya, Risha, Buist, A. Sonia, McBurnie, Mary Ann, Vollmer, William M., Gillespie, Suzanne, Sullivan, Sean, Lee, Todd A., Weiss, Kevin B., Jensen, Robert L., Crapo, Robert, Enright, Paul, Mannino, David M., Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, Abozid, Hazim, Burney, Peter, Hartl, Sylvia, Breyer-Kohansal, Robab, Al Ghobain, Mohammed, Denguezli, Meriam, Loh, Li Cher, Paraguas, Stefanni Nonna, Franssen, Frits M.E., Mannino, David, Anand, Mahesh Padukudru, Buist, Sonia, El Sony, Asma, Breyer, Marie-Kathrin, Burghuber, Otto C., Wouters, Emiel F.M., and Amaral, Andre F.S.

Published
2024
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2. Overdiagnosis of COPD in Subjects With Unobstructed Spirometry: A BOLD Analysis

Author

Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jingping, Zhou, Yumin, Kocabaş, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Studnicka, Michael, Dawes, Torkil, Lamprecht, Bernd, Sator, Lea, Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jörundsdottir, Kristin, Gudmundsdottir, Lovisa, Gudmundsdottir, Sigrun, Gundmundsson, Gunnar, Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Mejza, Filip, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, Schweda-Linow, Alexandra, Gulsvik, Amund, Endresen, Tina, Svendsen, Lene, Tan, Wan C., Wang, Wen, Mannino, David M., Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Francisco, Norberto A., Garcia, Gerard S., de Guia, Teresita S., Idolor, Luisito F., Naval, Sullian S., Reyes, Thessa, Roa, Camilo C., Jr., Sanchez, Ma. Flordeliza, Simpao, Leander P., Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Burney, Peter G.J., Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Wouters, E.F.M., Wesseling, G.J., Bárbara, Cristina, Rodrigues, Fátima, Dias, Hermínia, Cardoso, João, Almeida, João, Matos, Maria João, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Janson, Christer, Olafsdottir, Inga Sif, Nisser, Katarina, Spetz-Nyström, Ulrike, Hägg, Gunilla, Lund, Gun-Marie, Jõgi, Rain, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Harrabi, Imed, Denguezli, Myriam, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Jr., Reyes, Maria Teresita N., Juvekar, Sanjay, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Salvi, Sundeep, Brashier, Bill, Londhe, Jyoti, Madas, Sapna, Obaseki, Daniel, Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Horner, Andreas, Kaiser, Bernhard, McBurnie, Mary Ann, Buist, A. Sonia, Gnatiuc, Luisa, Bateman, Eric D., and Burney, Peter

Published
2019
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3. Chronic obstructive pulmonary disease mortality and prevalence: the associations with smoking and poverty—a BOLD analysis

Author

Burney, Peter, Jithoo, Anamika, Kato, Bernet, Janson, Christer, Mannino, David, Niżankowska-Mogilnicka, Ewa, Studnicka, Michael, Tan, Wan, Bateman, Eric, Koçabas, Ali, Vollmer, William M, Gislason, Thorarrin, Marks, Guy, Koul, Parvaiz A, Harrabi, Imed, Gnatiuc, Louisa, Buist, Sonia, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jingping, Zhou, Yumin, Kocabaş, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Studnicka, Michael, Dawes, Torkil, Lamprecht, Bernd, Schirhofer, Lea, Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jörundsdottir, Kristin, Gudmundsdottir, Lovisa, Gudmundsdottir, Sigrun, Gundmundsson, Gunnar, Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Mejza, Filip, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, Schweda-Linow, Alexandra, Gulsvik, Amund, Endresen, Tina, Svendsen, Lene, Tan, Wan C, Wang, Wen, Mannino, David M, Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, Dantes, Renato B, Amarillo, Lourdes, Berratio, Lakan U, Fernandez, Lenora C, Francisco, Norberto A, Garcia, Gerard S, de Guia, Teresita S, Idolor, Luisito F, Naval, Sullian S, Reyes, Thessa, Roa, Camilo C, Sanchez, Ma Flordeliza, Simpao, Leander P, Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Burney, Peter G J, Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Wouters, E F M, Wesseling, G J, Bárbara, Cristina, Rodrigues, Fátima, Dias, Hermínia, Cardoso, João, Almeida, João, Matos, Maria João, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Janson, Christer, Olafsdottir, Inga Sif, Nisser, Katarina, Spetz-Nyström, Ulrike, Hägg, Gunilla, Lund, Gun-Marie, Jõgi, Rain, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Koul, Parvaiz A, Malik, Sajjad, Hakim, Nissar A, Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Harrabi, Imed, Denguezli, Myriam, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Idolor, Luisito F, de Guia, Teresita S, Francisco, Norberto A, Roa, Camilo C, Ayuyao, Fernando G, Tady, Cecil Z, Tan, Daniel T, Banal-Yang, Sylvia, Balanag, Vincent M, Reyes, Maria Teresita N, Dantes, Renato B, Salvi, Sundeep, Hirve, Siddhi, Brashier, Bill, Londhe, Jyoti, Madas, Sapna, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Crapo, R O, Jensen, R L, Enright, Paul, and Harnoncourt, Georg

Published
2014
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4. Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study

Author

Ratanachina, Jate, Amaral, Andre F.S., De Matteis, Sara, Lawin, Herve, Mortimer, Kevin, Obaseki, Daniel O., Harrabi, Imed, Denguezli, Meriam, Wouters, Emiel F.M., Janson, Christer, Nielsen, Rune, Gulsvik, Amund, Cherkaski, Hamid Hacene, Mejza, Filip, Mahesh, Padukudru Anand, Elsony, Asma, Ahmed, Rana, Tan, Wan C., Loh, Li Cher, Rashid, Abdul, Studnicka, Michael, Nafees, Asaad A., Seemungal, Terence, Aquart-Stewart, Althea, Al Ghobain, Mohammed, Zheng, Jinping, Juvekar, Sanjay, Salvi, Sundeep, Jogi, Rain, Mannino, David M., Gislason, Thorarinn, Buist, A. Sonia, Cullinan, Paul, Burney, Peter G.J., Hafizi, Hasan, Aliko, Anila, Bardhi, Donika, Tafa, Holta, Thanasi, Natasha, Mezini, Arian, Teferici, Alma, Todri, Dafina, Nikolla, Jolanda, Kazasi, Rezarta, Bengrait, Amira, Haddad, Tabarek, Zgaoula, Ibtissem, Ghit, Maamar, Roubhia, Abdelhamid, Boudra, Soumaya, Atoui, Feryal, Yakoubi, Randa, Benali, Rachid, Bencheikh, Abdelghani, Ait-Khaled, Nadia, Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Dawes, Torkil, Lamprecht, Bernd, Schirhofer, Lea, Islam, Akramul, Ahmed, Syed Masud, Islam, Shayla, Islam, Qazi Shafayetul, Mesbah-Ul-Haque, NN, Chowdhury, Tridib Roy, Chatterjee, Sukantha Kumar, Mia, Dulal, Das, Shyamal Chandra, Rahman, Mizanur, Islam, Nazrul, Uddin, Shahaz, Islam, Nurul, Khatun, Luiza, Parvin, Monira, Khan, Abdul Awal, Islam, Maidul, Kpangon, Arsene, Kpossou, Karl, Agodokpessi, Gildas, Ayelo, Paul, Fayomi, Benjamin, Mbatchou, Bertrand, Ashu, Atongno Humphrey, Wang, Wen, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zhou, Yumin, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Adegnika, Ayola Akim, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, Schweda-Linow, Alexandra, Benedikdtsdottir, Bryndis, Jörundsdottir, Kristin, Gudmundsdottir, Lovisa, Gudmundsdottir, Sigrun, Gundmundsson, Gunnar, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Brashier, Sundeep Bill, Londhe, Jyoti, Madas, Sapna, Aikman, Althea Akosua Francia, Sooronbaev, Talant M., Estebesova, Bermet M., Akmatalieva, Meerim, Usenbaeva, Saadat, Kydyrova, Jypara, Bostonova, Eliza, Sheraliev, Ulan, Marajapov, Nuridin, Toktogulova, Nurgul, Emilov, Berik, Azilova, Toktogul, Beishekeeva, Gulnara, Dononbaeva, Nasyikat, Tabyshova, Aijamal, Mwangoka, Ernest, Kambwili, Mayamiko, Chipeta, Martha, Banda, Gloria, Mkandawire, Suzgo, Banda, Justice, Sholehah, Siti, Benjelloun, Mohamed C., Nejjari, Chakib, Elbiaze, Mohamed, El Rhazi, Karima, Franssen, F.F.E., Wesseling, G.J., Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Endresen, Tina, Svendsen, Lene Løvendahl, Irfan, Muhammad, Fatmi, Zafar, Zahidie, Aysha, Shaukat, Natasha, Iqbal, Meesha, Idolor, Luisito F., de Guia, Teresita S., Francisco, Norberto A., Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Reyes, Maria Teresita N., Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Garcia, Gerard S., Naval, Sullian S., Reyes, Thessa, Sanchez, Ma. Flordeliza, Simpao, Leander P., Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Bárbara, Cristina, Rodrigues, Fátima, Dias, Hermínia, Cardoso, João, Almeida, João, Matos, Maria João, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Alorainy, H., El-Hamad, E., Al Hajjaj, Hajjaj, Hashi, A., Dela, R., Fanuncio, R., Doloriel, E., Marciano, I., Safia, L., Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gunasekera, Kirthi, Wickremasinghe, Rajitha, Elsadig, Hana A., Osman, Nada Bakery, Noory, Bandar Salah, Mohamed, Monjda Awad, Osman, Hasab Alrasoul Akasha Ahmed, ed Elhassan, Namarig Moham, El Zain, Abdel Mu'is, Mohamaden, Marwa Mohamed, Khalifa, Suhaiba, Elhadi, Mahmoud, Hassan, Mohand, Abdelmonam, Dalia, Kamal, Rashid, Eltigani, Hind, Umar, Stephen's, Abdeen, Aya, Osman, Mihad, Mohamed, Malaz, Eltayeb, Roa, Abelazeez, Mohamed, Altaher, Hoyam, Mohamed, Lina, Abdarahman, Rabee, Mohamed, Rayan, Haram, NN, Ismaeel, Rimaz, Olafsdottir, Inga Sif, Nisser, Katarina, Spetz-Nyström, Ulrike, Hägg, Gunilla, Lund, Gun-Marie, Lutchmansingh, Fallon, Conyette, Liane, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Kocabaş, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Gnatiuc, Louisa, Azar, Hadia, Patel, Jaymini, Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Dudhaiya, Risha, McBurnie, Mary Ann, Vollmer, William M., Gillespie, Suzanne, Sullivan, Sean, Lee, Todd A., Weiss, Kevin B., Jensen, Robert L., Crapo, Robert, Enright, Paul, Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, and RS: NUTRIM - R3 - Respiratory & Age-related Health

Subjects
Pulmonary and Respiratory Medicine, Arbetsmedicin och miljömedicin, Respiratory Medicine and Allergy, Occupational Health and Environmental Health, Lungmedicin och allergi
Abstract

BackgroundChronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study.MethodsWe analysed cross-sectional data from 28 823 adults (≥40 years) in 34 countries. We considered 11 occupations and grouped them by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)/FVC with occupation was assessed, per study site, using multivariable regression. These estimates were then meta-analysed. Sensitivity analyses explored differences between sexes and gross national income.ResultsOverall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20 years were more likely to have chronic cough (OR 1.52, 95% CI 1.19–1.94), wheeze (OR 1.37, 95% CI 1.16–1.63) and dyspnoea (OR 1.83, 95% CI 1.53–2.20), but not lower FVC (β=0.02 L, 95% CI −0.02–0.06 L) or lower FEV1/FVC (β=0.04%, 95% CI −0.49–0.58%). Some findings differed by sex and gross national income.ConclusionAt a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they are associated with more respiratory symptoms. Because not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.

Published
2022

5. Prevalence and Population-Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study

Author

Burney, Peter, primary, Patel, Jaymini, additional, Minelli, Cosetta, additional, Gnatiuc, Louisa, additional, Amaral, André F. S., additional, Kocabaş, Ali, additional, Cherkaski, Hamid Hacene, additional, Gulsvik, Amund, additional, Nielsen, Rune, additional, Bateman, Eric, additional, Jithoo, Anamika, additional, Mortimer, Kevin, additional, Sooronbaev, Talant M., additional, Lawin, Hervé, additional, Nejjari, Chakib, additional, Elbiaze, Mohammed, additional, El Rhazi, Karima, additional, Zheng, Jin-Ping, additional, Ran, Pixin, additional, Welte, Tobias, additional, Obaseki, Daniel, additional, Erhabor, Gregory, additional, Elsony, Asma, additional, Osman, Nada Bakri, additional, Ahmed, Rana, additional, Nizankowska-Mogilnicka, Ewa, additional, Mejza, Filip, additional, Mannino, David M., additional, Bárbara, Cristina, additional, Wouters, Emiel F. M., additional, Idolor, Luisito F., additional, Loh, Li-Cher, additional, Rashid, Abdul, additional, Juvekar, Sanjay, additional, Gislason, Thorarinn, additional, Al Ghobain, Mohamed, additional, Studnicka, Michael, additional, Harrabi, Imed, additional, Denguezli, Meriam, additional, Koul, Parvaiz A., additional, Jenkins, Christine, additional, Marks, Guy, additional, Jõgi, Rain, additional, Hafizi, Hasan, additional, Janson, Christer, additional, Tan, Wan C., additional, Aquart-Stewart, Althea, additional, Mbatchou, Bertrand, additional, Nafees, Asaad Ahmed, additional, Gunasekera, Kirthi, additional, Seemungal, Terry, additional, Anand, Mahesh Padukudru, additional, Enright, Paul, additional, Vollmer, William M., additional, Blangiardo, Marta, additional, Elfadaly, Fadlalla G., additional, Buist, A. Sonia, additional, Aliko, Anila, additional, Bardhi, Donika, additional, Tafa, Holta, additional, Thanasi, Natasha, additional, Mezini, Arian, additional, Teferici, Alma, additional, Todri, Dafina, additional, Nikolla, Jolanda, additional, Kazasi, Rezarta, additional, Bengrait, Amira, additional, Haddad, Tabarek, additional, Zgaoula, Ibtissem, additional, Ghit, Maamar, additional, Roubhia, Abdelhamid, additional, Boudra, Soumaya, additional, Atoui, Feryal, additional, Yakoubi, Randa, additional, Benali, Rachid, additional, Bencheikh, Abdelghani, additional, Ait-Khaled, Nadia, additional, Bird, Tessa, additional, Espinel, Paola, additional, Hardaker, Kate, additional, Toelle, Brett, additional, Dawes, Torkil, additional, Lamprecht, Bernd, additional, Schirhofer, Lea, additional, Islam, Akramul, additional, Ahmed, Syed Masud, additional, Islam, Shayla, additional, Islam, Qazi Shafayetul, additional, Chowdhury, Tridib Roy, additional, Chatterjee, Sukantha Kumar, additional, Mia, Dulal, additional, Das, Shyamal Chandra, additional, Rahman, Mizanur, additional, Islam, Nazrul, additional, Uddin, Shahaz, additional, Islam, Nurul, additional, Khatun, Luiza, additional, Parvin, Monira, additional, Khan, Abdul Awal, additional, Islam, Maidul, additional, Lawin, Herve, additional, Kpangon, Arsene, additional, Kpossou, Karl, additional, Agodokpessi, Gildas, additional, Ayelo, Paul, additional, Fayomi, Benjamin, additional, Ashu, Atongno Humphrey, additional, Wang, Wen, additional, Zhong, NanShan, additional, Liu, Shengming, additional, Lu, Jiachun, additional, Wang, Dali, additional, Zheng, Jin-ping, additional, Zhou, Yumin, additional, Laja, Hendrik, additional, Ulst, Katrin, additional, Zobel, Vappu, additional, Lill, Toomas-Julius, additional, Adegnika, Ayola Akim, additional, Bodemann, Isabelle, additional, Geldmacher, Henning, additional, Schweda-Linow, Alexandra, additional, Benedikdtsdottir, Bryndis, additional, Jörundsdottir, Kristin, additional, Gudmundsdottir, Lovisa, additional, Gudmundsdottir, Sigrun, additional, Gudmundsson, Gunnar, additional, Rao, Mahesh, additional, Malik, Sajjad, additional, Hakim, Nissar A., additional, Khan, Umar Hafiz, additional, Chowgule, Rohini, additional, Shetye, Vasant, additional, Raphael, Jonelle, additional, Almeda, Rosel, additional, Tawde, Mahesh, additional, Tadvi, Rafiq, additional, Katkar, Sunil, additional, Kadam, Milind, additional, Dhanawade, Rupesh, additional, Ghurup, Umesh, additional, Hirve, Siddhi, additional, Sambhudas, Somnath, additional, Chaidhary, Bharat, additional, Tambe, Meera, additional, Pingale, Savita, additional, Umap, Arati, additional, Umap, Archana, additional, Shelar, Nitin, additional, Devchakke, Sampada, additional, Chaudhary, Sharda, additional, Bondre, Suvarna, additional, Walke, Savita, additional, Gawhane, Ashleshsa, additional, Sapkal, Anil, additional, Argade, Rupali, additional, Gaikwad, Vijay, additional, Salvi, Sundeep, additional, Brashier, Bill, additional, Londhe, Jyoti, additional, Madas, Sapna, additional, Aikman, Akosua Francia, additional, Estebesova, Bermet M., additional, Akmatalieva, Meerim, additional, Usenbaeva, Saadat, additional, Kydyrova, Jypara, additional, Bostonova, Eliza, additional, Sheraliev, Ulan, additional, Marajapov, Nuridin, additional, Toktogulova, Nurgul, additional, Emilov, Berik, additional, Azilova, Toktogul, additional, Beishekeeva, Gulnara, additional, Dononbaeva, Nasyikat, additional, Tabyshova, Aijamal, additional, Nyapigoti, Wezzie, additional, Mwangoka, Ernest, additional, Kambwili, Mayamiko, additional, Chipeta, Martha, additional, Banda, Gloria, additional, Mkandawire, Suzgo, additional, Banda, Justice, additional, Sholehah, Siti, additional, Benjelloun, Mohamed C., additional, Elbiaze, Mohamed, additional, Wouters, E. F. M., additional, Wesseling, G. J., additional, Awopeju, Olayemi, additional, Adewole, Olufemi, additional, Endresen, Tina, additional, Svendsen, Lene, additional, Nafees, Asaad A., additional, de Guia, Teresita S., additional, Francisco, Norberto A., additional, Roa, Camilo C., additional, Ayuyao, Fernando G., additional, Tady, Cecil Z., additional, Tan, Daniel T., additional, Banal-Yang, Sylvia, additional, Balanag, Vincent M., additional, Reyes, Maria Teresita N., additional, Dantes, Renato. B., additional, Dantes, Renato B., additional, Amarillo, Lourdes, additional, Berratio, Lakan U., additional, Fernandez, Lenora C., additional, Garcia, Gerard S., additional, Naval, Sullian S., additional, Reyes, Thessa, additional, Sanchez, Ma. Flordeliza, additional, Simpao, Leander P., additional, Frey, Jakub, additional, Harat, Rafal, additional, Nastalek, Pawel, additional, Pajak, Andrzej, additional, Skucha, Wojciech, additional, Szczeklik, Andrzej, additional, Twardowska, Magda, additional, Rodrigues, Fátima, additional, Dias, Hermínia, additional, Cardoso, João, additional, Almeida, João, additional, Matos, Maria João, additional, Simão, Paula, additional, Santos, Moutinho, additional, Ferreira, Reis, additional, Al Ghobain, M., additional, Alorainy, H., additional, El-Hamad, E., additional, Al Hajjaj, M., additional, Hashi, A., additional, Dela, R., additional, Fanuncio, R., additional, Doloriel, E., additional, Marciano, I., additional, Safia, L., additional, Adams, Desiree, additional, Barnes, Edward, additional, Freeman, Jasper, additional, Hayes, Anton, additional, Hlengwa, Sipho, additional, Johannisen, Christine, additional, Koopman, Mariana, additional, Louw, Innocentia, additional, Ludick, Ina, additional, Olckers, Alta, additional, Ryck, Johanna, additional, Storbeck, Janita, additional, Wickremasinghe, Rajitha, additional, Elsadig, Hana A., additional, Osman, Nada Bakery, additional, Noory, Bandar Salah, additional, Mohamed, Monjda Awad, additional, Osman, Hasab Alrasoul Akasha Ahmed, additional, ed Elhassan, Namarig Moham, additional, Mu‘is El Zain, Abdel, additional, Mohamaden, Marwa Mohamed, additional, Khalifa, Suhaiba, additional, Elhadi, Mahmoud, additional, Hassan, Mohand, additional, Abdelmonam, Dalia, additional, Olafsdottir, Inga Sif, additional, Nisser, Katarina, additional, Spetz-Nyström, Ulrike, additional, Hägg, Gunilla, additional, Lund, Gun-Marie, additional, Seemungal, Terence, additional, Lutchmansingh, Fallon, additional, Conyette, Liane, additional, Denguezli, Myriam, additional, Tabka, Zouhair, additional, Daldoul, Hager, additional, Boukheroufa, Zaki, additional, Chouikha, Firas, additional, Khalifa, Wahbi Belhaj, additional, Hancioglu, Attila, additional, Hanta, Ismail, additional, Kuleci, Sedat, additional, Turkyilmaz, Ahmet Sinan, additional, Umut, Sema, additional, Unalan, Turgay, additional, Burney, Peter G. J., additional, Azar, Hadia, additional, Amor, Caron, additional, Potts, James, additional, Tumilty, Michael, additional, McLean, Fiona, additional, Dudhaiya, Risha, additional, McBurnie, Mary Ann, additional, Gillespie, Suzanne, additional, Sullivan, Sean, additional, Lee, Todd A., additional, Weiss, Kevin B., additional, Jensen, Robert L., additional, Crapo, Robert, additional, Cain, John, additional, Copeland, Rebecca, additional, Hazen, Dana, additional, and Methvin, Jennifer, additional

Published
2021
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6. Prevalence and Population-Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study

Author

Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M., Bárbara, Cristina, Wouters, Emiel F. M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A., Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C., Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., Buist, A. Sonia, Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M., Bárbara, Cristina, Wouters, Emiel F. M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A., Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C., Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., and Buist, A. Sonia

Abstract

Rationale: The Global Burden of Disease program identified smoking and ambient and household air pollution as the main drivers of death and disability from chronic obstructive pulmonary disease (COPD). Objectives: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors. Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged ≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a postbronchodilator FEV1-to-FVC ratio less than the lower limit of normal, and the relative risks associated with different risk factors. Local relative risks were estimated using a Bayesian hierarchical model borrowing information from across sites. From these relative risks and the prevalence of risk factors, we estimated local population attributable risks. Measurements and Main Results: The mean prevalence of CAO was 11.2% in men and 8.6% in women. The mean population attributable risk for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index, and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites. Conclusions: Although smoking remains the most important risk factor for CAO, in some areas, poor education, low body mass index, and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.

Published
2021
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7. COPD: Should Diagnosis Match Physiology?

Author

Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jingping, Zhou, Yumin, Kocabaş, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Studnicka, Michael, Dawes, Torkil, Lamprecht, Bernd, Sator, Lea, Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jörundsdottir, Kristin, Gudmundsdottir, Lovisa, Gudmundsdottir, Sigrun, Gundmundsson, Gunnar, Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Mejza, Filip, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, Schweda-Linow, Alexandra, Gulsvik, Amund, Endresen, Tina, Svendsen, Lene, Tan, Wan C., Wang, Wen, Mannino, David M., Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Francisco, Norberto A., Garcia, Gerard S., de Guia, Teresita S., Idolor, Luisito F., Naval, Sullian S., Reyes, Thessa, Roa, Camilo C., Jr, Sanchez, Ma. Flordeliza, Simpao, Leander P., Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Burney, Peter G.J., Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Wouters, E.F.M., Wesseling, G.J., Bárbara, Cristina, Rodrigues, Fátima, Dias, Hermínia, Cardoso, João, Almeida, João, Matos, Maria João, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Janson, Christer, Olafsdottir, Inga Sif, Nisser, Katarina, Spetz-Nyström, Ulrike, Hägg, Gunilla, Lund, Gun-Marie, Jõgi, Rain, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Harrabi, Imed, Denguezli, Myriam, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Roa, Camilo C., Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Jr, Reyes, Maria Teresita N., Dantes, Renato. B., Juvekar, Sanjay, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Salvi, Sundeep, Brashier, Bill, Londhe, Jyoti, Madas, Sapna, Obaseki, Daniel, Erhabor, Gregory, Awopeju, Olayemi, Adewole, Olufemi, Horner, Andreas, and Buist, A. Sonia

Published
2020
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8. COPD: should diagnosis match physiology?

Author

Studnicka, Michael, Horner, Andreas, Sator, Lea, Buist, A. Sonia, Lamprecht, Bernd, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jingping, Zhou, Yumin, Kocabaş, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Dawes, Torkil, Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jörundsdottir, Kristin, Gudmundsdottir, Lovisa, Gudmundsdottir, Sigrun, Gundmundsson, Gunnar, Nizankowska-Mogilnicka, Ewa, Frey, Jakub, Harat, Rafal, Mejza, Filip, Nastalek, Pawel, Pajak, Andrzej, Skucha, Wojciech, Szczeklik, Andrzej, Twardowska, Magda, Welte, Tobias, Bodemann, Isabelle, Geldmacher, Henning, Schweda-Linow, Alexandra, Gulsvik, Amund, Endresen, Tina, Svendsen, Lene, Tan, Wan C., Wang, Wen, Mannino, David M., Cain, John, Copeland, Rebecca, Hazen, Dana, Methvin, Jennifer, Dantes, Renato B., Amarillo, Lourdes, Berratio, Lakan U., Fernandez, Lenora C., Francisco, Norberto A., Garcia, Gerard S., de Guia, Teresita S., Idolor, Luisito F., Naval, Sullian S., Reyes, Thessa, Roa, Camilo C., Sanchez, Ma. Flordeliza, Simpao, Leander P., Jenkins, Christine, Marks, Guy, Bird, Tessa, Espinel, Paola, Hardaker, Kate, Toelle, Brett, Burney, Peter G.J., Amor, Caron, Potts, James, Tumilty, Michael, McLean, Fiona, Wouters, E.F.M., Wesseling, G.J., Bárbara, Cristina, Rodrigues, Fátima, Dias, Hermínia, Cardoso, João, Almeida, João, Matos, Maria João, Simão, Paula, Santos, Moutinho, Ferreira, Reis, Janson, Christer, Olafsdottir, Inga Sif, Nisser, Katarina, Spetz-Nyström, Ulrike, Hägg, Gunilla, Lund, Gun-Marie, Jõgi, Rain, Laja, Hendrik, Ulst, Katrin, Zobel, Vappu, Lill, Toomas-Julius, Koul, Parvaiz A., Malik, Sajjad, Hakim, Nissar A., Khan, Umar Hafiz, Chowgule, Rohini, Shetye, Vasant, Raphael, Jonelle, Almeda, Rosel, Tawde, Mahesh, Tadvi, Rafiq, Katkar, Sunil, Kadam, Milind, Dhanawade, Rupesh, Ghurup, Umesh, Harrabi, Imed, Denguezli, Myriam, Tabka, Zouhair, Daldoul, Hager, Boukheroufa, Zaki, Chouikha, Firas, Khalifa, Wahbi Belhaj, Ayuyao, Fernando G., Tady, Cecil Z., Tan, Daniel T., Banal-Yang, Sylvia, Balanag, Vincent M., Reyes, Maria Teresita N., Dantes, Renato. B., Juvekar, Sanjay, Hirve, Siddhi, Sambhudas, Somnath, Chaidhary, Bharat, Tambe, Meera, Pingale, Savita, Umap, Arati, Umap, Archana, Shelar, Nitin, Devchakke, Sampada, Chaudhary, Sharda, Bondre, Suvarna, Walke, Savita, Gawhane, Ashleshsa, Sapkal, Anil, Argade, Rupali, Gaikwad, Vijay, Salvi, Sundeep, Brashier, Bill, Londhe, Jyoti, Madas, Sapna, Obaseki, Daniel, Erhabor, Gregory, Awopeju, Olayemi, and Adewole, Olufemi

Subjects
Spirometry, Chronic obstructive pulmonary disease, Humans
Abstract

Submitted by Maria da Luz Antunes (mluz.antunes@estesl.ipl.pt) on 2020-12-08T16:58:31Z No. of bitstreams: 1 COPD_should diagnosis match physiology.pdf: 83490 bytes, checksum: bbbfcb5fa3e4d33e5d07d47e299641c6 (MD5) Made available in DSpace on 2020-12-08T16:58:31Z (GMT). No. of bitstreams: 1 COPD_should diagnosis match physiology.pdf: 83490 bytes, checksum: bbbfcb5fa3e4d33e5d07d47e299641c6 (MD5) Previous issue date: 2020-02 info:eu-repo/semantics/publishedVersion

Published
2020

9. Association between passive smoking and infection with Mycobacterium tuberculosis in Children

Author

den Boon, Saskia, Verver, Suzanne, Marais, Ben J., Enarson, Donald A., Lombard, Carl J., Bateman, Eric D., Irusen, Elvis, Jithoo, Anamika, Gie, Robert P., Borgdorff, Martien W., and Beyers, Nulda

Subjects
Passive smoking -- Complications and side effects, Tuberculosis -- Risk factors, Children -- Diseases, Children -- Risk factors
Abstract

OBJECTIVE. Tuberculosis and smoking are both significant public health problems. The association between passive smoking and Mycabacterium tuberculosis infection is not well documented. The objective of this study was to examine the influence of passive smoking on M tuberculosis infection in children. METHODS. A community survey was conducted in 15% of addresses in 2 adjacent low-income suburbs in Cape Town, South Africa. All children ( RESULTS. Of 1344 children, 432 (32%) had a positive tuberculin skin test. Passive smoking was significantly associated with M tuberculosis infection in the unadjusted analyses but not in the adjusted analyses. In the 172 households with a patient with tuberculosis, passive smoking was significantly associated with a positive tuberculin skin test (but not in the 492 households without a patient with tuberculosis. CONCLUSIONS. Passive smoking is associated with M tuberculosis infection in children living in a household with a patient with tuberculosis. More studies are needed to confirm this observation, but the possible association is a cause of great concern, considering the high prevalence of smoking and tuberculosis in most developing countries. Key Words children, tuberculosis, infection, smoking, RECENTLY, WE REPORTED that cigarette smoking is associated with Mycobacterium tuberculosis infection in adults, (1) a finding confirmed in several other studies. (2-6) Few studies have investigated the association between [...]

Published
2007

12. COPD

Author

Studnicka, Michael, primary, Horner, Andreas, additional, Sator, Lea, additional, Buist, A. Sonia, additional, Lamprecht, Bernd, additional, Zhong, NanShan, additional, Liu, Shengming, additional, Lu, Jiachun, additional, Ran, Pixin, additional, Wang, Dali, additional, Zheng, Jingping, additional, Zhou, Yumin, additional, Kocabaş, Ali, additional, Hancioglu, Attila, additional, Hanta, Ismail, additional, Kuleci, Sedat, additional, Turkyilmaz, Ahmet Sinan, additional, Umut, Sema, additional, Unalan, Turgay, additional, Studnicka, Michael, additional, Dawes, Torkil, additional, Bateman, Eric, additional, Jithoo, Anamika, additional, Adams, Desiree, additional, Barnes, Edward, additional, Freeman, Jasper, additional, Hayes, Anton, additional, Hlengwa, Sipho, additional, Johannisen, Christine, additional, Koopman, Mariana, additional, Louw, Innocentia, additional, Ludick, Ina, additional, Olckers, Alta, additional, Ryck, Johanna, additional, Storbeck, Janita, additional, Gislason, Thorarinn, additional, Benedikdtsdottir, Bryndis, additional, Jörundsdottir, Kristin, additional, Gudmundsdottir, Lovisa, additional, Gudmundsdottir, Sigrun, additional, Gundmundsson, Gunnar, additional, Nizankowska-Mogilnicka, Ewa, additional, Frey, Jakub, additional, Harat, Rafal, additional, Mejza, Filip, additional, Nastalek, Pawel, additional, Pajak, Andrzej, additional, Skucha, Wojciech, additional, Szczeklik, Andrzej, additional, Twardowska, Magda, additional, Welte, Tobias, additional, Bodemann, Isabelle, additional, Geldmacher, Henning, additional, Schweda-Linow, Alexandra, additional, Gulsvik, Amund, additional, Endresen, Tina, additional, Svendsen, Lene, additional, Tan, Wan C., additional, Wang, Wen, additional, Mannino, David M., additional, Cain, John, additional, Copeland, Rebecca, additional, Hazen, Dana, additional, Methvin, Jennifer, additional, Dantes, Renato B., additional, Amarillo, Lourdes, additional, Berratio, Lakan U., additional, Fernandez, Lenora C., additional, Francisco, Norberto A., additional, Garcia, Gerard S., additional, de Guia, Teresita S., additional, Idolor, Luisito F., additional, Naval, Sullian S., additional, Reyes, Thessa, additional, Roa, Camilo C., additional, Sanchez, Ma. Flordeliza, additional, Simpao, Leander P., additional, Jenkins, Christine, additional, Marks, Guy, additional, Bird, Tessa, additional, Espinel, Paola, additional, Hardaker, Kate, additional, Toelle, Brett, additional, Burney, Peter G.J., additional, Amor, Caron, additional, Potts, James, additional, Tumilty, Michael, additional, McLean, Fiona, additional, Wouters, E.F.M., additional, Wesseling, G.J., additional, Bárbara, Cristina, additional, Rodrigues, Fátima, additional, Dias, Hermínia, additional, Cardoso, João, additional, Almeida, João, additional, Matos, Maria João, additional, Simão, Paula, additional, Santos, Moutinho, additional, Ferreira, Reis, additional, Janson, Christer, additional, Olafsdottir, Inga Sif, additional, Nisser, Katarina, additional, Spetz-Nyström, Ulrike, additional, Hägg, Gunilla, additional, Lund, Gun-Marie, additional, Jõgi, Rain, additional, Laja, Hendrik, additional, Ulst, Katrin, additional, Zobel, Vappu, additional, Lill, Toomas-Julius, additional, Koul, Parvaiz A., additional, Malik, Sajjad, additional, Hakim, Nissar A., additional, Khan, Umar Hafiz, additional, Chowgule, Rohini, additional, Shetye, Vasant, additional, Raphael, Jonelle, additional, Almeda, Rosel, additional, Tawde, Mahesh, additional, Tadvi, Rafiq, additional, Katkar, Sunil, additional, Kadam, Milind, additional, Dhanawade, Rupesh, additional, Ghurup, Umesh, additional, Harrabi, Imed, additional, Denguezli, Myriam, additional, Tabka, Zouhair, additional, Daldoul, Hager, additional, Boukheroufa, Zaki, additional, Chouikha, Firas, additional, Khalifa, Wahbi Belhaj, additional, Ayuyao, Fernando G., additional, Tady, Cecil Z., additional, Tan, Daniel T., additional, Banal-Yang, Sylvia, additional, Balanag, Vincent M., additional, Reyes, Maria Teresita N., additional, Dantes, Renato. B., additional, Juvekar, Sanjay, additional, Hirve, Siddhi, additional, Sambhudas, Somnath, additional, Chaidhary, Bharat, additional, Tambe, Meera, additional, Pingale, Savita, additional, Umap, Arati, additional, Umap, Archana, additional, Shelar, Nitin, additional, Devchakke, Sampada, additional, Chaudhary, Sharda, additional, Bondre, Suvarna, additional, Walke, Savita, additional, Gawhane, Ashleshsa, additional, Sapkal, Anil, additional, Argade, Rupali, additional, Gaikwad, Vijay, additional, Salvi, Sundeep, additional, Brashier, Bill, additional, Londhe, Jyoti, additional, Madas, Sapna, additional, Obaseki, Daniel, additional, Erhabor, Gregory, additional, Awopeju, Olayemi, additional, and Adewole, Olufemi, additional

Published
2020
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13. Overdiagnosis of COPD in Subjects With Unobstructed Spirometry A BOLD Analysis

Author

Sator, Lea, Horner, Andreas, Studnicka, Michael, Lamprecht, Bernd, Kaiser, Bernhard, McBurnie, Mary Ann, Buist, A. Sonia, Gnatiuc, Luisa, Mannino, David M., Janson, Christer, Bateman, Eric D., Burney, Peter, Zhong, NanShan, Liu, Shengming, Lu, Jiachun, Ran, Pixin, Wang, Dali, Zheng, Jingping, Zhou, Yumin, Kocabas, Ali, Hancioglu, Attila, Hanta, Ismail, Kuleci, Sedat, Turkyilmaz, Ahmet Sinan, Umut, Sema, Unalan, Turgay, Dawes, Torkil, Bateman, Eric, Jithoo, Anamika, Adams, Desiree, Barnes, Edward, Freeman, Jasper, Hayes, Anton, Hlengwa, Sipho, Johannisen, Christine, Koopman, Mariana, Louw, Innocentia, Ludick, Ina, Olckers, Alta, Ryck, Johanna, Storbeck, Janita, Gislason, Thorarinn, Benedikdtsdottir, Bryndis, Jorundsdottir, Kristin, Gudmundsdottir, Lovisa, Gudmundsdottir, Sigrun, Gundmundsson, Gunnar, Nizankowska-Mogilnicka, Ewa, Wouters, E. F. M., Wesseling, G. J., MUMC+: MA Longziekten (3), RS: NUTRIM - R3 - Respiratory & Age-related Health, Pulmonologie, MUMC+: MA Med Staf Spec Longziekten (9), and RS: CAPHRI - R5 - Optimising Patient Care

Subjects
COUNTRIES, SYMPTOMS, overtreatment, false positive diagnosis, ACCURACY, overdiagnosis, DIAGNOSIS, OBSTRUCTIVE PULMONARY-DISEASE, PREVALENCE, UNDERDIAGNOSIS, DEFINITIONS, SEVERITY, COPD, QUALITY, misdiagnosis
Abstract

BACKGROUND: There are several reports on underdiagnosis of COPD, while little is known about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries participating in the BOLD Study between 2003 and 2012. METHODS: A false positive diagnosis of COPD was considered when participants reported a doctor's diagnosis of COPD, but postbronchodilator spirometry was unobstructed (FEV1/FVC > LLN). Additional analyses were performed using the fixed ratio criterion (FEV1/FVC

Published
2019

14. Case-finding options for COPD : results from the Burden of Obstructive Lung Disease study

Author

Jithoo, Anamika, Enright, Paul, Burney, Peter, Buist, A., Bateman, Eric, Tan, Wan, Studnicka, Michael, Mejza, Filip, Gillespie, Suzanne, Vollmer, William, BOLD Collaborative Research Group, Niżankowska-Mogilnicka, Ewa, Nastałek, Paweł, and Pająk, Andrzej

Subjects
Pulmonary and Respiratory Medicine, Spirometry, Adult, Male, medicine.medical_specialty, Cost-Benefit Analysis, Population, Pulmonary disease, Peak Expiratory Flow Rate, Sensitivity and Specificity, Article, Decision Support Techniques, Pulmonary Disease, Chronic Obstructive, Internal medicine, Surveys and Questionnaires, Epidemiology, Pulmonary Medicine, Medicine, Humans, education, Aged, COPD, education.field_of_study, medicine.diagnostic_test, business.industry, Middle Aged, Models, Theoretical, medicine.disease, Obstructive lung disease, respiratory tract diseases, Respiratory Function Tests, Cost analysis, Physical therapy, Case finding, Female, business, Algorithms
Abstract

This study aimed to compare strategies for chronic obstructive pulmonary disease (COPD) case finding using data from the Burden of Obstructive Lung Disease study. Population-based samples of adults aged ≥40 yrs (n = 9,390) from 14 countries completed a questionnaire and spirometry. We compared the screening efficiency of differently staged algorithms that used questionnaire data and/or peak expiratory flow (PEF) data to identify persons at risk for COPD and, hence, needing confirmatory spirometry. Separate algorithms were fitted for moderate/severe COPD and for severe COPD. We estimated the cost of each algorithm in 1,000 people. For moderate/severe COPD, use of questionnaire data alone permitted high sensitivity (97%) but required confirmatory spirometry in 80% of participants. Use of PEF necessitated confirmatory spirometry in only 19-22% of subjects, with 83-84% sensitivity. For severe COPD, use of PEF achieved 91-93% sensitivity, requiring confirmatory spirometry in

Published
2013

16. Risk factors for tuberculosis in a low-income urban area of Cape Town, South Africa, with particular reference to the role of cannabis smoking

Author

Jithoo, Anamika and Bateman, Eric D

Subjects
Tuberculosis, Public Health
Abstract

Background: The association between Mycobacterium tuberculosis infection and tobacco smoking has recently been highlighted. The reason for this association remains unclear, but is postulated to result from the effects of smoking on pulmonary host defences. Cannabis impairs the immune function of alveolar macrophages and has been reported to increase susceptibility to respiratory infections. Aim: To examine risk factors for both Mycobacterium tuberculosis disease and infection, in particular the effects of cannabis smoking. Methods: A cross-sectional population survey of 3512 persons aged ≥15 years was performed in a predominantly low-income urban area of Cape Town, South Africa. Information on a history of tuberculosis and various risk factors including cannabis smoking was collected by means of an administered questionnaire. Ziehl-Neelson stained sputum smears were examined for acid fast bacilli and cultured on Lowenstein Jensen slants. Tuberculin skin testing (TST) was performed and an induration of ≥10mm read after 48-72 hours was considered positive. One joint year is defined as one joint per day for one year. Results: The prevalence of ever smoking cannabis was 11.3% (23% in men; 2.6% in women) and 6.4% were current smokers. A history of tuberculosis was reported by 9.7%; current disease confirmed in 1 %, and 76% had a positive TST. After adjusting for age, sex, tobacco smoking, income, education, occupational exposure, incarceration, alcohol use and body mass index, persons with a cumulative cannabis exposure of >70 joint years (approximately equivalent to 20 tobacco packyears) had an increased risk of past/current tuberculosis disease (OR 3.2; Cl:1.8 - 5.6). Cannabis joint years did not show an association with tuberculosis infection. Conclusions: This population study shows that cannabis smoking is positively associated with past/current tuberculosis disease, suggesting that cannabis may be a risk factor in the development of tuberculous disease.

Published
2007

17. Respiratory symptoms and chronic obstructive pulmonary disease : prevalence and risk factors in a predominantly low-income urban area of Cape Town, South Africa

Author

Jithoo, Anamika, Bateman, Eric D, White, Neil, and Burney, Peter

Subjects
InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Medicine, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Includes bibliographical references., The continuing worldwide increase in the incidence of chronic obstructive pulmonary disease (COPD) has led to international initiatives to improve surveillance and identify preventable risk factors for this and related chronic lung diseases. The studies reported here aimed to examine the prevalence and risk factors for respiratory symptoms and COPD; to introduce and test surveillance methodologies; and to inform treatment and control measures for this disease. The Lung Health Survey 2002 sampled 3512 individuals aged ≥ 15 years from an urban population of 36,334 in the predominantly low-income area of Ravensmead and Uitsig, Cape Town, South Africa. Information on respiratory symptoms, risk factors and healthcare utilisation was collected using a respiratory questionnaire which included questions that had been validated elsewhere. In 2005, a subsample of 960 persons aged ≥ 40 years participated in the Burden of Obstructive Lung Disease (BOLD) study comprised of a questionnaire and pre and postbronchodilator spirometry, in order to assess the prevalence of COPD. A high prevalence of respiratory symptoms of 38.3% was reported. Tobacco smoking showed a consistent positive association with chronic bronchitis, wheeze, dyspnoea and cough. Strong associations with cannabis smoking, pulmonary tuberculosis, occupational exposures and low socioeconomic status were found. The association of cannabis smoking with respiratory symptoms suggest that it may be a risk factor for COPD. The BOLD study revealed an exceptionally high prevalence of COPD in both men and women aged 40 years and older (29% and 20%, respectively) reflecting the very high prevalence of smoking in both sexes in the test area. The majority of those affected had moderate to severe disease, that is, symptoms with spirometric impairment (GOLD Stage II and higher). Even non-smoking women had a comparatively high prevalence of CO PO (12.6%), attributable to other risk factors such as tuberculosis and occupational exposures. Previous pulmonary tuberculosis was shown to be a strong predictor of COPD, which warrants further study. Review of healthcare utilisation confirmed significant under-recognition and under-treatment within local health services. These results confirm the need to prioritise preventative and treatment strategies for obstructive lung disease in South Africa.

Published
2006

21. The Prevalence Of Reported Cardiovascular Disease In Subjects With Non-Reversible Airways Obstruction - Findings From The Multi-Center Population-Based Burden Of Obstructive Lung Disease (BOLD) Study

Author

Studnicka, Michael, primary, McBurnie, Mary A., additional, Tan, Wan C., additional, Gulsvik, Amund, additional, Gislason, Thorarinn, additional, Kocabas, Ali, additional, Bateman, Erick, additional, Jithoo, Anamika, additional, Janson, Christer, additional, Jenkins, C, additional, Welte, Tobias, additional, Mejza, Filip, additional, Lamprecht, Bernd, additional, Wouters, Emiel F., additional, and Buist, A. Sonia, additional

Published
2011
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24. Prevalence and Population Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study

Author

Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M, Bárbara, Cristina, Wouters, Emiel F.M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A, Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C, Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., Buist, A. Sonia, Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M, Bárbara, Cristina, Wouters, Emiel F.M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A, Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C, Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., and Buist, A. Sonia

Abstract

Rationale: The Global Burden of Disease programme identified smoking, and ambient and household air pollution as the main drivers of death and disability from Chronic Obstructive Pulmonary Disease (COPD). Objective: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors. Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a post-bronchodilator one-second forced expiratory volume to forced vital capacity ratio < lower limit of normal, and the relative risks associated with different risk factors. Local RR were estimated using a Bayesian hierarchical model borrowing information from across sites. From these RR and the prevalence of risk factors, we estimated local Population Attributable Risks (PAR). Measurements and Main Results: Mean prevalence of CAO was 11.2% in men and 8.6% in women. Mean PAR for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index (BMI), and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites. Conclusions: While smoking remains the most important risk factor for CAO, in some areas poor education, low BMI and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.

25. Prevalence and Population Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study

Author

Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M, Bárbara, Cristina, Wouters, Emiel F.M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A, Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C, Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., Buist, A. Sonia, Burney, Peter, Patel, Jaymini, Minelli, Cosetta, Gnatiuc, Louisa, Amaral, André F. S., Kocabaş, Ali, Cherkaski, Hamid Hacene, Gulsvik, Amund, Nielsen, Rune, Bateman, Eric, Jithoo, Anamika, Mortimer, Kevin, Sooronbaev, Talant M., Lawin, Hervé, Nejjari, Chakib, Elbiaze, Mohammed, El Rhazi, Karima, Zheng, Jin-Ping, Ran, Pixin, Welte, Tobias, Obaseki, Daniel, Erhabor, Gregory, Elsony, Asma, Osman, Nada Bakri, Ahmed, Rana, Nizankowska-Mogilnicka, Ewa, Mejza, Filip, Mannino, David M, Bárbara, Cristina, Wouters, Emiel F.M., Idolor, Luisito F., Loh, Li-Cher, Rashid, Abdul, Juvekar, Sanjay, Gislason, Thorarinn, Al Ghobain, Mohamed, Studnicka, Michael, Harrabi, Imed, Denguezli, Meriam, Koul, Parvaiz A, Jenkins, Christine, Marks, Guy, Jõgi, Rain, Hafizi, Hasan, Janson, Christer, Tan, Wan C, Aquart-Stewart, Althea, Mbatchou, Bertrand, Nafees, Asaad, Gunasekera, Kirthi, Seemungal, Terry, Padukudru Anand, Mahesh, Enright, Paul, Vollmer, William M., Blangiardo, Marta, Elfadaly, Fadlalla G., and Buist, A. Sonia

Abstract

Rationale: The Global Burden of Disease programme identified smoking, and ambient and household air pollution as the main drivers of death and disability from Chronic Obstructive Pulmonary Disease (COPD). Objective: To estimate the attributable risk of chronic airflow obstruction (CAO), a quantifiable characteristic of COPD, due to several risk factors. Methods: The Burden of Obstructive Lung Disease study is a cross-sectional study of adults, aged≥40, in a globally distributed sample of 41 urban and rural sites. Based on data from 28,459 participants, we estimated the prevalence of CAO, defined as a post-bronchodilator one-second forced expiratory volume to forced vital capacity ratio < lower limit of normal, and the relative risks associated with different risk factors. Local RR were estimated using a Bayesian hierarchical model borrowing information from across sites. From these RR and the prevalence of risk factors, we estimated local Population Attributable Risks (PAR). Measurements and Main Results: Mean prevalence of CAO was 11.2% in men and 8.6% in women. Mean PAR for smoking was 5.1% in men and 2.2% in women. The next most influential risk factors were poor education levels, working in a dusty job for ≥10 years, low body mass index (BMI), and a history of tuberculosis. The risk of CAO attributable to the different risk factors varied across sites. Conclusions: While smoking remains the most important risk factor for CAO, in some areas poor education, low BMI and passive smoking are of greater importance. Dusty occupations and tuberculosis are important risk factors at some sites.

26. Case-finding options for COPD: results from the Burden of Obstructive Lung Disease study.

Author

Jithoo A, Enright PL, Burney P, Buist AS, Bateman ED, Tan WC, Studnicka M, Mejza F, Gillespie S, and Vollmer WM

Subjects
Adult, Aged, Algorithms, Cost-Benefit Analysis, Decision Support Techniques, Female, Humans, Male, Middle Aged, Models, Theoretical, Pulmonary Medicine methods, Pulmonary Medicine standards, Sensitivity and Specificity, Spirometry methods, Surveys and Questionnaires, Peak Expiratory Flow Rate, Pulmonary Disease, Chronic Obstructive diagnosis, Pulmonary Disease, Chronic Obstructive physiopathology, Respiratory Function Tests economics
Abstract

This study aimed to compare strategies for chronic obstructive pulmonary disease (COPD) case finding using data from the Burden of Obstructive Lung Disease study. Population-based samples of adults aged ≥40 yrs (n = 9,390) from 14 countries completed a questionnaire and spirometry. We compared the screening efficiency of differently staged algorithms that used questionnaire data and/or peak expiratory flow (PEF) data to identify persons at risk for COPD and, hence, needing confirmatory spirometry. Separate algorithms were fitted for moderate/severe COPD and for severe COPD. We estimated the cost of each algorithm in 1,000 people. For moderate/severe COPD, use of questionnaire data alone permitted high sensitivity (97%) but required confirmatory spirometry in 80% of participants. Use of PEF necessitated confirmatory spirometry in only 19-22% of subjects, with 83-84% sensitivity. For severe COPD, use of PEF achieved 91-93% sensitivity, requiring confirmatory spirometry in <9% of participants. Cost analysis suggested that a staged screening algorithm using only PEF initially, followed by confirmatory spirometry as needed, was the most cost-effective case-finding strategy. Our results support the use of PEF as a simple, cost-effective initial screening tool for conducting COPD case-finding in adults aged ≥40 yrs. These findings should be validated in real-world settings such as the primary care environment.

Published
2013
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27. Risk factors for COPD spirometrically defined from the lower limit of normal in the BOLD project.

Author

Hooper R, Burney P, Vollmer WM, McBurnie MA, Gislason T, Tan WC, Jithoo A, Kocabas A, Welte T, and Buist AS

Subjects
Adult, Aged, Body Mass Index, Educational Status, Female, Humans, Male, Middle Aged, Multicenter Studies as Topic statistics & numerical data, Prevalence, Pulmonary Disease, Chronic Obstructive diagnosis, Pulmonary Disease, Chronic Obstructive etiology, Risk Factors, Smoking adverse effects, Smoking epidemiology, Spirometry methods, Tobacco Smoke Pollution adverse effects, Tobacco Smoke Pollution statistics & numerical data, Tuberculosis, Pulmonary complications, Tuberculosis, Pulmonary epidemiology, Pulmonary Disease, Chronic Obstructive epidemiology
Abstract

Chronic obstructive pulmonary disease (COPD) is predicted to become the third most common cause of death and disability worldwide by 2020. The prevalence of COPD defined by the lower limit of normal was estimated using high-quality spirometry in surveys of 14 populations aged ≥ 40 yrs. The strength and consistency of associations were assessed using random effects meta-analysis. Pack-years of smoking were associated with risk of COPD at each site. After adjusting for this effect, we still observed significant associations of COPD risk with age (OR 1.52 for a 10 yr age difference, 95% CI 1.35-1.71), body mass index in obese compared with normal weight (OR 0.50, 95% CI 0.37-0.67), level of education completed (OR 0.76, 95% CI 0.67-0.87), hospitalisation with a respiratory problem before age 10 yrs (OR 2.35, 95% CI 1.42-3.91), passive cigarette smoke exposure (OR 1.24, 95% CI 1.05-1.47), tuberculosis (OR 1.78, 95%CI 1.17-2.72) and a family history of COPD (OR 1.50, 95% CI 1.19-1.90). Although smoking is the most important risk factor for COPD, other risk factors are also important. More research is required to elucidate relevant risk factors in low- and middle-income countries where the greatest impact of COPD will occur.

Published
2012
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28. Lung diseases in South Africa: an overview.

Author

Bateman ED and Jithoo A

Subjects
HIV Infections complications, HIV Infections epidemiology, Humans, Lung Diseases etiology, Lung Diseases pathology, Risk Factors, South Africa epidemiology, Tuberculosis complications, Tuberculosis epidemiology, Lung Diseases epidemiology
Abstract

The profile of both infectious and non-infectious lung diseases in South Africa over the past century reflects prevailing sociopolitical and economic forces. The lung, perhaps more than any other organ system is influenced by poverty, occupation and personal habits. These influences are seen in the association between tuberculosis and pneumoconiosis first described in miners, the increasing prevalence of asthma and smoking-related chronic obstructive pulmonary disease, and the current dual epidemics of tuberculosis and infections associated with the human immunodeficiency virus (HIV). The global prediction for developing countries is that by the year 2020 respiratory diseases (including infections) will account for a large majority of deaths and a considerable burden of disability adjusted life years. The country-wide Demographic and Health Surveys of 1998 and 2003 have provided data on symptom prevalence in South Africa. The Lung Health Survey 2002 performed in Cape Town provides disease prevalence and has identified complex interactions between causative factors and disease. Consistent and biologically plausible associations between smoking and susceptibility to tuberculosis and pneumonia in HIV-infected patients have been reported. These findings are relevant both to the planners of public health interventions, and to researchers exploring disease mechanisms and potential remedies.

Published
2006

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