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Accurate diagnosis of sewer inflow and infiltration (I/I) is crucial for ensuring the safe transportation of sewage and the stability of wastewater treatment processes. Identifying periods impacted by I/I is essential for I/I diagnosis, but current methods lack a standard criterion and require adaptation to specific conditions, resulting in low accuracy, complexity, and limited generalizability. This paper proposes a novel approach to distinguish I/I periods from time series of sewer measurements based on anomaly detection theory through an iterative use of a time-series reconstruction model. This method eliminates the need for external data such as rainfalls and avoids intensive manual data analysis. Operating directly on in-sewer data, it enhances accuracy compared to existing approaches and is applicable to various external factors such as rainfall, snowmelt, and seawater intrusion. The method can be applicable to a broad range of monitoring data, including flow rate, temperature, and conductivity. Validated through simulation studies and demonstrated via real-life applications, this method offers an efficient solution for I/I detection, facilitating further I/I diagnosis, including I/I quantification and location identification.

The study proposes two innovative algorithms in the field of multi-beam echo sounder (MBES) simulation: distance-aided sound ray marching (DASRM) and height-aided sound ray marching (HASRM). These algorithms aim to enhance the efficiency and accuracy of MBES simulations, particularly when dealing with long-distance propagation and real-time processing limitations. DASRM addresses issues related to simulation accuracy by efficiently utilizing the KD-tree for spatial indexing and intersection detection instead of the signed distance field (SDF). Building upon the further analysis of DASRM, HASRM is proposed, which improves the search strategy for ray intersections and utilizes a height field pyramid for sampling and retrieval, thereby reducing memory usage while enhancing indexing efficiency. The experimental results demonstrate that both algorithms significantly outperform traditional methods in terms of simulation time, with HASRM exhibiting particular advantages in parallel computing due to its data structure and improved strategies. Additionally, DASRM is well suited for applications requiring complex scene construction, while HASRM proves especially effective in simulating MBES with a focus on underwater terrain due to its effectiveness in handling large incident angles and long-distance propagation.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by its highly aggressive behavior, early recurrence, and poor outcomes, when compared with other subtypes. Due to the absence of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, TNBC lacks meaningful biomarkers and an effective therapeutic strategy. Chemotherapy remains the main adjuvant treatment for patients with TNBC. Anthracycline/taxane-based regimens are the standard of care in adjuvant settings. The addition of capecitabine or platinum may offer extra benefits to patients with TNBC, but at the cost of increased toxicity or adverse events. Dose-dense chemotherapy may enhance treatment efficacy in patients who are able to tolerate the treatment regimen, especially in high-risk patients. As a heterogenous disease, TNBC can be classified into several molecular subtypes according to genomic or transcriptional features, which may indicate potential targets for more precise and individualized treatment strategies. With our increased understanding of signal pathways associated with TNBC, as well as the discovery of novel biomarkers indicative of TNBC prognosis, several new therapeutic options are under investigation, and some have already reported good results. In this review, we summarized the current conventional therapeutic strategies and emerging clinical trials regarding adjuvant treatment for TNBC. Furthermore, we evaluated the prognostic value of several potential targets and the progress of targeted therapy in TNBC, both in neoadjuvant and adjuvant settings.

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of midbrain dopaminergic neurons. The miR-29s family, including miR-29a and miR-29b1 as well as miR-29b2 and miR-29c, are implicated in aging, metabolism, neuronal survival, and neurological disorders. In this study, the roles of miR-29a/b1 in aging and PD were investigated. miR-29a/b1 knockout mice (named as 29a KO hereafter) and their wild-type (WT) controls were used to analyze aging-related phenotypes. After challenged with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), dopaminergic injuries, glial activation, and mouse behaviors were evaluated. Primary glial cells were further cultured to explore the underlying mechanisms. Additionally, the levels of miR-29s in the cerebrospinal fluid (CSF) of PD patients (n = 18) and healthy subjects (n = 17) were quantified. 29a KO mice showed dramatic weight loss, kyphosis, and along with increased and deepened wrinkles in skins, when compared with WT mice. Moreover, both abdominal and brown adipose tissues reduced in 29a KO mice, compared to their WT counterpart. However, in MPTP-induced PD mouse model, the deficiency of miR-29a/b1 led to less severe damages of dopaminergic system and mitigated glial activation in the nigrostriatal pathway, and subsequently alleviated the motor impairments in 3-month-old mice. Eight-month-old mutant mice maintained such a resistance to MPTP intoxication. Mechanistically, the deficiency of miR-29a/b-1 promoted the expression of neurotrophic factors in 1-Methyl-4-phenylpyridinium (MPP+)-treated primary mixed glia and primary astrocytes. In lipopolysaccharide (LPS)-treated primary microglia, knockout of miR-29a/b-1 inhibited the expression of inflammatory factors, and promoted the expression of anti-inflammatory factors and neurotrophic factors. Knockout of miR-29a/b1 increased the activity of AMP-activated protein kinase (AMPK) and repressed NF-κB/p65 signaling in glial cells. Moreover, we found miR-29a level was increased in the CSF of patients with PD. Our results suggest that 29a KO mice display the peripheral premature senility. The combined effects of less activated glial cells might contribute to the mitigated inflammatory responses and elicit resistance to MPTP intoxication in miR-29a/b1 KO mice.

The aim of the present study was to test the relationship between selfie-viewing on social media and restrained eating as well as the mediating effect of thin-ideal internalization in this relationship. We also examined whether the links from selfie-viewing to thin-ideal internalization and restrained eating would be moderated by media literacy. Moreover, whether gender would moderate the mediation model was also examined. Results on a survey of 1,481 Chinese adolescents aged 12–⁠19 years showed that selfie-viewing had a positive relationship with restrained eating and that thin-ideal internalization mediated this relationship. Furthermore, the association between selfie-viewing and thin-ideal internalization was moderated by media literacy. Specifically, the relationship was weaker for adolescents with higher media literacy. In other words, media literacy alleviated the negative effect of selfie-viewing on body image. Moreover, there were no gender differences in the mediation model. These findings add to the literature on the relationship between social media use and restrained eating. Educational programs aiming to improve media literacy may be beneficial for reducing the risk of restrained eating among adolescents.

The present study investigated the association between body talk on social networking sites (SNS) and body dissatisfaction as well as the mediating effects of appearance ideals internalization and appearance comparison in this relationship. Participants were 476 Chinese college students who completed questionnaires regarding SNS body talk, thin-ideal internalization, muscular-ideal internalization, general attractiveness internalization, appearance comparison, and body dissatisfaction. Results indicated that SNS body talk was positively linked to body dissatisfaction. The relationship between SNS body talk and body dissatisfaction was mediated by thin-ideal internalization and muscular-ideal internalization while the mediating effects of general attractiveness internalization and appearance comparison in this relationship were nonsignificant. Moderated mediation analysis further revealed that thin-ideal internalization mediated the association for women but not men and that other indirect effects did not differ among genders. The findings of this study provide more insights into the relationship between SNS use and body image.