143 results on '"Jingran Liu"'
Search Results
2. Revisiting the structure of the Yale Global Tic Severity Scale (YGTSS) in a sample of Chinese children with tic disorders
- Author
-
Fang Wen, Yi Gu, Junjuan Yan, Jingran Liu, Fang Wang, Liping Yu, Ying Li, and Yonghua Cui
- Subjects
YGTSS ,Reliability ,Validity ,Confirmatory factor analysis ,China ,Psychiatry ,RC435-571 - Abstract
Abstract Background To the best of our knowledge, although the Chinese version of the Yale Global Tic Severity Scale (YGTSS) is widely used in child psychiatry departments in China, there is very little evidence focusing on the psychometric characteristics of the Chinese version of YGTSS. In this present study, we aim to re-examine the structure of the Chinese version of YGTSS and investigate its reliability and validity. Methods A total of 367 children and adolescents with tic disorders aged 5–16 years old participated in the study. The Cronbach’s alpha, test-retest reliability and concurrent validity will be calculated. Confirmatory Factor Analysis (CFA) also will be performed to assess the structure of YGTSS. Results The Cronbach’s alpha of the motor tic subscale of YGTSS was 0.84, for the phonic tic subscale of YGTSS, it was 0.90, but for the whole scale, it was 0.58. The test-retest reliability of YGTSS was 0.84. For the results of CFA, the Comparative Fit Index (CFI) of YGTSS based on the Two-Factor Model and Three-Factor Model was 0.97 and 0.96 respectively. The measurement invariance analysis suggested that the Two-Factor model of YGTSS across different age and sex groups was at the accepted level (≥0.90). Conclusion Overall, according to the results of this research, it suggested that the Chinese version of YGTSS showed good psychometric properties. It can be used in the assessment of tic disorders in the Chinese population. In the future, more comprehensive tools for assessing tics need to be further developed, which can cover the symptoms of premonitory urge and tic related obsessive-compulsive symptoms.
- Published
- 2021
- Full Text
- View/download PDF
3. Grey matter abnormalities in Tourette syndrome: an activation likelihood estimation meta-analysis
- Author
-
Fang Wen, Junjuan Yan, Liping Yu, Fang Wang, Jingran Liu, Ying Li, and Yonghua Cui
- Subjects
Grey matter ,Tourette syndrome ,ALE ,Voxel-based morphometry ,Thalamus ,Psychiatry ,RC435-571 - Abstract
Abstract Background Tourette syndrome (TS) is a neurodevelopmental disorder defined by the continual presence of primary motor and vocal tics. Grey matter abnormalities have been identified in numerous studies of TS, but conflicting results have been reported. This study was an unbiased statistical meta-analysis of published neuroimaging studies of TS structures. Methods A voxel quantitative meta-analysis technique called activation likelihood estimation (ALE) was used. The meta-analysis included six neuroimaging studies involving 247 TS patients and 236 healthy controls. A statistical threshold of p
- Published
- 2021
- Full Text
- View/download PDF
4. Gray Matter Alterations in Pediatric Schizophrenia and Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies
- Author
-
Jingran Liu, Fang Wen, Junjuan Yan, Liping Yu, Fang Wang, Duo Wang, Jishui Zhang, Chunmei Yan, Jiahui Chu, Yanlin Li, Ying Li, and Yonghua Cui
- Subjects
schizophrenia ,obsessive-compulsive disorders ,activation likelihood estimation ,gray matter ,children and adolescents ,Psychiatry ,RC435-571 - Abstract
ObjectiveThe aim of this study is comparing gray matter alterations in SCZ pediatric patients with those suffering from obsessive-compulsive disorder (OCD) based on a systematic review and an activation likelihood estimation (ALE) meta-analysis.MethodsA systematic literature search was performed in PubMed, Elsevier, and China National Knowledge Infrastructure (CNKI). A systematic review and an ALE meta-analysis were performed to quantitatively examine brain gray matter alterations.ResultsChildren and adolescents with schizophrenia had decreased gray matter volume (GMV) mainly in the prefrontal cortex (PFC), temporal cortex (such as the middle temporal gyrus and transverse temporal gyrus), and insula, while children and adolescents with OCD mainly had increased GMV in the PFC and the striatum (including the lentiform nucleus and caudate nucleus), and decreased GMV in the parietal cortex.ConclusionsOur results suggest that gray matter abnormalities in the PFC may indicate homogeneity between the two diseases. In children and adolescents, structural alterations in schizophrenia mainly involve the fronto-temporal and cortico-insula circuits, whereas those in OCD mainly involve the prefrontal-parietal and the prefrontal-striatal circuits.
- Published
- 2022
- Full Text
- View/download PDF
5. Long-Term Soil Drought Limits Starch Accumulation by Altering Sucrose Transport and Starch Synthesis in Sweet Potato Tuberous Root
- Author
-
Minfei Sheng, Houqiang Xia, Huizi Ding, Dongyu Pan, Jinping He, Zongyun Li, and Jingran Liu
- Subjects
sweet potato ,sucrose and starch metabolism ,drought treatment ,acid invertase ,sucrose-will-eventually-be-exported transporter (SWEET) ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
In this study, the influences of long-term soil drought with three levels [soil-relative water content (SRWC) (75 ± 5)%, as the control; SRWC (55 ± 5)%, mild drought; SRWC (45 ± 5)%, severe drought] were investigated on sucrose-starch metabolism in sweet potato tuberous roots (TRs) by pot experiment. Compared to the control, drought stress increased soluble sugar and sucrose content by 4–60% and 9–75%, respectively, but reduced starch accumulation by 30–66% through decreasing the starch accumulate rate in TRs. In the drought-treated TRs, the inhibition of sucrose decomposition was attributed to the reduced activities of acid invertase (AI) and alkaline invertase (AKI) and the IbA-INV3 expression, rather than sucrose synthase (SuSy), consequently leading to the increased sucrose content in TRs. In addition, starch synthesis was inhibited mainly by reducing ADP-glucose pyrophosphorylase (AGPase), granular starch synthase (GBSS) and starch branching enzyme (SBE) activities in TRs under drought stress, and AGPase was the rate-limiting enzyme. Furthermore, soil drought remarkably up-regulated the IbSWEET11, IbSWEET605, and IbSUT4 expressions in Jishu 26 TRs, while it down-regulated or had no significant differences in Xushu 32 and Ningzishu 1 TRs. These results suggested that the sucrose-loading capability in Jishu 26 TRs were stronger than that in Xushu 32 and Ningzishu 1 TRs. Moreover, IbA-INV3, IbAGPS1, IbAGPS2, IbGBSSI and IbSBEII play important roles in different drought-tolerant cultivars under drought stress.
- Published
- 2023
- Full Text
- View/download PDF
6. Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder and Tic Disorder: A Quick Review
- Author
-
Liping Yu, Yanlin Li, Junjuan Yan, Fang Wen, Fang Wang, Jingran Liu, Yonghua Cui, and Ying Li
- Subjects
obsession-compulsive disorder ,tic disorder ,tourette syndrome ,repeated transcranial magnetic stimulation ,supplementary motor area ,low-frequency ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Repetitive transcranial megnetic stimulation (rTMS) has been widely used in patients with psychiatric disorders. Previous studies revealed good efficacy of rTMS for patients with obsession-compulsive disorder (OCD) and Tic disorder (TD). OCD and TD are closely related and considered to etiologically overlap. Patients with the co-occurrence of OCD and TD are often identified. Therefore, we conducted a quick review of rTMS for the treatment of these two diseases to compare the similarities and differences of rTMS for OCD and TD, which might provide an indication for the treatment of the co-occurrence of OCD and TD. We searched articles published in PubMed, Wanfang, and Web of Science from January 2001 to January 2022. Both inclusion criteria and exclusion criteria were developed to identify the relevant included studies. Data on the frequency, target area, sample size, and number of males, especially the rTMS treatment procedure or parameters, were extracted in the included studies. We included 26 studies on OCD and 12 studies on TD in this quick review. A total of 996 participants were included. Based on the review of the included studies, lowfrequency rTMS might be used more than high-frequency rTMS, and the supplementary motor area (SMA) might show better efficacy than the dorsolateral prefrontal cortex (DLPFC) in OCD. For patients with TD, low-frequency rTMS located in the SMA might show good efficacy both in OCD and TD. Our quick review elaborated the treatment efficacy of rTMS for both patients with OCD and those with TD. It seems that the SMA is an important target choice for both OCD and TD patients. Low-frequency rTMS might be used more than high-frequency rTMS in both OCD and TD patients. In future studies, we should explore more about the efficacy of rTMS for patients with co-occurring OCD and TD, especially for the efficacy of targeted SMA with low frequency.
- Published
- 2022
- Full Text
- View/download PDF
7. Psychometric Properties of the Chinese Version of the Premonitory Urge for Tics Scale: A Preliminary Report
- Author
-
Ying Li, Douglas W. Woods, Yi Gu, Liping Yu, Junjuan Yan, Fang Wen, Fang Wang, Jingran Liu, and Yonghua Cui
- Subjects
premonitory urge ,tic disorders ,PUTS ,psychometric properties ,network analysis ,Psychology ,BF1-990 - Abstract
Premonitory urges (PUs) are sensory phenomena that immediately precede tics. The Premonitory Urge for Tics Scale (PUTS) is widely used to assess the severity of PUs, but the psychometric properties of PUTS and clinical features of PU in Chinese patients with tic disorders are still unclear. In this study, we examined the psychometric properties of the Chinese version of the PUTS in a large sample (including 367 Chinese pediatric patients with tic disorders). We found no difference in PU in different age groups. The exploratory factor analysis (EFA) of PUTS showed the emergence of four primary factors. The results of reliability and validity analyses indicated that the Chinese version showed good psychometric properties. It seemed that PU was associated with the severity of obsession symptoms in patients with tic disorders. Network analysis showed that Item 7 is a critical node for the PU, in addition to Items 1 and 4. Overall, the Chinese version of PUTS can be used in Chinese child and adolescent patients with tic disorders, particularly for patients with Tourette syndrome.
- Published
- 2021
- Full Text
- View/download PDF
8. Continuous crystalline graphene papers with gigapascal strength by intercalation modulated plasticization
- Author
-
Peng Li, Mincheng Yang, Yingjun Liu, Huasong Qin, Jingran Liu, Zhen Xu, Yilun Liu, Fanxu Meng, Jiahao Lin, Fang Wang, and Chao Gao
- Subjects
Science - Abstract
Strong but flexible graphene tends to wrinkle, which compromises some properties. Here the authors report a solid plasticization method to prepare continuous graphene papers with high crystalline order, achieving high strength, stiffness, electrical and thermal conductivities.
- Published
- 2020
- Full Text
- View/download PDF
9. Influence of Hexagonal Boron Nitride on Electronic Structure of Graphene
- Author
-
Jingran Liu, Chaobo Luo, Haolin Lu, Zhongkai Huang, Guankui Long, and Xiangyang Peng
- Subjects
graphene ,boron nitride ,density of states ,Fermi velocity ,charge transfer ,Organic chemistry ,QD241-441 - Abstract
By performing first-principles calculations, we studied hexagonal-boron-nitride (hBN)-supported graphene, in which moiré structures are formed due to lattice mismatch or interlayer rotation. A series of graphene/hBN systems has been studied to reveal the evolution of properties with respect to different twisting angles (21.78°, 13.1°, 9.43°, 7.34°, 5.1°, and 3.48°). Although AA- and AB-stacked graphene/hBN are gapped at the Dirac point by about 50 meV, the energy gap of the moiré graphene/hBN, which is much more asymmetric, is only about several meV. Although the Dirac cone of graphene residing in the wide gap of hBN is not much affected, the calculated Fermi velocity is found to decrease with the increase in the moiré super lattice constant due to charge transfer. The periodic potential imposed by hBN modulated charge distributions in graphene, leading to the shift of graphene bands. In agreement with experiments, there are dips in the calculated density of states, which get closer and closer to the Fermi energy as the moiré lattice grows larger.
- Published
- 2022
- Full Text
- View/download PDF
10. Phosphorus affects enzymatic activity and chemical properties of cotton soil
- Author
-
Yang Gao, Huiyi Huang, Hongyi Zhao, Houqiang Xia, Miao Sun, Zongyun Li, Pengcheng Li, Cangsong Zheng, Helin Dong, and Jingran Liu
- Subjects
soil available phosphorus ,soil enzymes ,c, n and p availability ,plant nutrition ,fertilization ,soil microorganisms ,Plant culture ,SB1-1110 - Abstract
Pot experiments were conducted in 2017 with two cotton cultivars (CCRI 79 and LMY 28) and three phosphorus (P) levels: 3, 8 and 12 mg P2O5/kg as P0, P1 and P2, respectively. In this study, the soil water-soluble organic carbon content increased as the soil available P (AP) increased, while there were no significant variations for soil total organic matter content among the three AP levels. The activities of invertase, cellulase and urease in cotton soil decreased significantly in the P0. There were positive correlations between invertase and cellulose activities with soil organic carbon and inorganic-nitrogen (N); these correlated negatively with soil C/N ratio and AP level. In addition, high soil AP can raise soil AP and enhance alkaline phosphatase activity, which had a significant negative relationship with the soil C/P ratio. Urease activity had a significant positive relationship with soil NH4+-N, C/P and N/P, as well as a negative correlation with soil C/N. Moreover, soil NH4+-N and NO3--N in the P1 and P2 were lower than in the P0, which might be an effect of high AP on soil N availability.
- Published
- 2019
- Full Text
- View/download PDF
11. The Prevalence and Comorbidity of Tic Disorders and Obsessive-Compulsive Disorder in Chinese School Students Aged 6–16: A National Survey
- Author
-
Junjuan Yan, Hu Deng, Yongming Wang, Xiaolin Wang, Tengteng Fan, Shijie Li, Fang Wen, Liping Yu, Fang Wang, Jingran Liu, Yuanzhen Wu, Yi Zheng, Yonghua Cui, and Ying Li
- Subjects
China ,tic disorders ,obsessive-compulsive disorder ,prevalence ,children ,adolescents ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: Obsessive-compulsive disorder (OCD) and tic disorders (TDs) are closely related and considered to etiologically overlap. Both disorders are characterized by repetitive behaviors. TD and OCD often co-occur. The high comorbidity between OCD and TD individuals suggests that we also need to pay more attention to the homogeneity and heterogeneity between TS and OCD. To date, there has been no systematic nationwide epidemiological survey of the mental health (including tic disorders and obsessive-compulsive disorder) of children and adolescents in China. Methods: A two-stage epidemiological study of psychiatric point prevalence was conducted. We used the multistage cluster stratified random sampling strategy to assess five provinces of China. The Child Behavior Checklist was used to identify behavioral problems among the enrolled students in the first stage. The results from the Mini-International Neuropsychiatric Interview for Children and Adolescents and evaluations from two psychiatrists based on the Diagnostic and Statistical Manual-IV were used to make a diagnosis. Point weighted prevalence for TD and OCD was estimated. We adjusted prevalence estimates with the product of sampling weights and poststratification weights. Standard error values and 95% confidential intervals were generated with Taylor series linearization. Rao–Scott adjusted chi-square (χ2) tests were employed to compare the prevalence estimates of different age and sex groups. Results: In the first stage, 73,992 participants aged 6–16 years old were selected. The prevalence rates of OCD and TDs were 1.37% (95% CI: 1.28–1.45) and 2.46% (95% CI: 2.35–2.57), respectively. The prevalence of OCD was found to be higher in girls (p < 0.001) and higher in boys with transient tic disorder (TTD) (p < 0.001) and Tourette’s syndrome (TS) (p < 0.001). The most common comorbidity of TS was OCD (40.73%), and for OCD, it was TS (11.36%). Conclusions: Our study is the first nationwide survey on the prevalence of TD (2.46%) and OCD (1.37%) in school students aged 6–16 years old in China. The high comorbidity between OCD and TD individuals suggested overlap based on the prevalence dimensions, which might be influenced by age and sex. This result suggested that we also need to pay more attention to the homogeneity and heterogeneity between TS and OCD.
- Published
- 2022
- Full Text
- View/download PDF
12. RNA-Seq and iTRAQ reveal multiple pathways involved in storage root formation and development in sweet potato (Ipomoea batatas L.)
- Author
-
Tingting Dong, Mingku Zhu, Jiawen Yu, Rongpeng Han, Cheng Tang, Tao Xu, Jingran Liu, and Zongyun Li
- Subjects
Sweet potato ,Storage root ,Transcriptome ,iTRAQ ,Starch ,Plant hormone ,Botany ,QK1-989 - Abstract
Abstract Background Sweet potato (Ipomoea batatas L.) is the sixth most important food crop in the world. The formation and development of storage roots in sweet potato is a highly complicated and genetically programmed process. However, the underlying mechanisms of storage root development have not yet been elucidated. Results To better understand the molecular mechanisms involved in storage root development, a combined analysis of the transcriptome and proteome of sweet potato fibrous roots (F) and storage roots at four different stages (D1, D3, D5 and D10) was performed in the present study. A total of 26,273 differentially expressed genes were identified in a comparison between the fibrous root library and four storage root libraries, while 2558 proteins showed a 1.0-fold or greater expression difference as indicated by isobaric tags for relative and absolute quantitation (iTRAQ) analysis. The combination of the transcriptome and proteome analyses and morphological and physiological data revealed several critical pathways involved in storage root formation and development. First, genes/proteins involved in the development of meristems/cambia and starch biosynthesis were all significantly upregulated in storage roots compared with fibrous roots. Second, multiple phytohormones and the genes related to their biosynthesis showed differential expression between fibrous roots and storage roots. Third, a large number of transcription factors were differentially expressed during storage root initiation and development, which suggests the importance of transcription factor regulation in the development of storage roots. Fourth, inconsistent gene expression was found between the transcriptome and proteome data, which indicated posttranscriptional regulatory activity during the development of storage roots. Conclusion Overall, these results reveal multiple events associated with storage root development and provide new insights into the molecular mechanisms underlying the regulatory networks involved in storage root development.
- Published
- 2019
- Full Text
- View/download PDF
13. Multi-Scale Structure–Mechanical Property Relations of Graphene-Based Layer Materials
- Author
-
Jingran Liu, Huasong Qin, and Yilun Liu
- Subjects
graphene-based layer materials ,multi-scale structure–property relations ,mechanical behaviors ,hierarchical structures ,multi-scale optimization ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
Pristine graphene is one of the strongest materials known in the world, and may play important roles in structural and functional materials. In order to utilize the extraordinary mechanical properties in practical engineering structures, graphene should be assembled into macroscopic structures such as graphene-based papers, fibers, foams, etc. However, the mechanical properties of graphene-based materials such as Young’s modulus and strength are 1–2 orders lower than those of pristine monolayer graphene. Many efforts have been made to unveil the multi-scale structure–property relations of graphene-based materials with hierarchical structures spanning the nanoscale to macroscale, and significant achievements have been obtained to improve the mechanical performance of graphene-based materials through composition and structure optimization across multi-scale. This review aims at summarizing the currently theoretical, simulation, and experimental efforts devoted to the multi-scale structure–property relation of graphene-based layer materials including defective monolayer graphene, nacre-like and laminar nanostructures of multilayer graphene, graphene-based papers, fibers, aerogels, and graphene/polymer composites. The mechanisms of mechanical property degradation across the multi-scale are discussed, based on which some multi-scale optimization strategies are presented to further improve the mechanical properties of graphene-based layer materials. We expect that this review can provide useful insights into the continuous improvement of mechanical properties of graphene-based layer materials.
- Published
- 2021
- Full Text
- View/download PDF
14. Potassium Fertilization Stimulates Sucrose-to-Starch Conversion and Root Formation in Sweet Potato (Ipomoea batatas (L.) Lam.)
- Author
-
Yang Gao, Zhonghou Tang, Houqiang Xia, Minfei Sheng, Ming Liu, Shenyuan Pan, Zongyun Li, and Jingran Liu
- Subjects
sweet potato (Ipomoea batatas (L.) Lam.) ,potassium fertilization ,storage root ,biomass production ,sucrose-to-starch conversion ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
A field experiment was established to study sweet potato growth, starch dynamic accumulation, key enzymes and gene transcription in the sucrose-to-starch conversion and their relationships under six K2O rates using Ningzishu 1 (sensitive to low-K) and Xushu 32 (tolerant to low-K). The results indicated that K application significantly improved the biomass accumulation of plant and storage root, although treatments at high levels of K, i.e., 300–375 kg K2O ha−1, significantly decreased plant biomass and storage root yield. Compared with the no-K treatment, K application enhanced the biomass accumulation of plant and storage root by 3–47% and 13–45%, respectively, through promoting the biomass accumulation rate. Additionally, K application also enhanced the photosynthetic capacity of sweet potato. In this study, low stomatal conductance and net photosynthetic rate (Pn) accompanied with decreased intercellular CO2 concentration were observed in the no-K treatment at 35 DAT, indicating that Pn was reduced mainly due to stomatal limitation; at 55 DAT, reduced Pn in the no-K treatment was caused by non-stomatal factors. Compared with the no-K treatment, the content of sucrose, amylose and amylopectin decreased by 9–34%, 9–23% and 6–19%, respectively, but starch accumulation increased by 11–21% under K supply. The activities of sucrose synthetase (SuSy), adenosine-diphosphate-glucose pyrophosphorylase (AGPase), starch synthase (SSS) and the transcription of Susy, AGP, SSS34 and SSS67 were enhanced by K application and had positive relationships with starch accumulation. Therefore, K application promoted starch accumulation and storage root yield through regulating the activities and genes transcription of SuSy, AGPase and SSS in the sucrose-to-starch conversion.
- Published
- 2021
- Full Text
- View/download PDF
15. Drought-Induced Responses of Nitrogen Metabolism in Ipomoea batatas
- Author
-
Houqiang Xia, Tao Xu, Jing Zhang, Ke Shen, Zongyun Li, and Jingran Liu
- Subjects
Ipomoea batatas sweet potato ,nitrate uptake ,ammonium uptake and accumulation ,gene transcription ,drought stress ,Botany ,QK1-989 - Abstract
This study investigated the effect of water stress, simulated by the polyethylene glycol (PEG-6000) method, on nitrogen (N) metabolism in leaves and roots of hydroponically grown sweet potato seedlings, Xushu 32 (X32) and Ningzishu 1 (N1). The concentrations of PEG-6000 treatments were 0%, 5% and 10% (m/v). The results showed that the drought-treated plants showed a decline leaf relative water content, and revealed severe growth inhibition, compared with the 0% treatment. Under drought stress, the decline in biomass of the leaf and stem was more noticeable than in root biomass for X32, leading to a higher root to shoot ratio. Drought stress increased the nitrate nitrogen (NO3−-N) and protein in leaves, but reduced all the activities of N-metabolism enzymes and the transcriptional levels of nitrate reductase (NR), glutamine synthetase (GS) and glutamate synthase (GOGAT); in roots, NO3−-N and NR had opposite trends. The leaf ammonium nitrogen (NH4+-N), GS and amino acid had different trends between X32 and N1 under drought stress. Furthermore, the transcriptional level of nitrate transporter genes NRT1.1 in leaves and roots were upregulated under drought stress, except in N1 roots. In conclusion, NR determined the different response to drought in leaves for X32 and N1, and GS and GOGAT determined the response to drought in roots, respectively.
- Published
- 2020
- Full Text
- View/download PDF
16. Effects of Soil Salinity on Sucrose Metabolism in Cotton Fiber.
- Author
-
Jun Peng, Lei Zhang, Jingran Liu, Junyu Luo, Xinhua Zhao, Helin Dong, Yan Ma, Ning Sui, Zhiguo Zhou, and Yali Meng
- Subjects
Medicine ,Science - Abstract
Cotton (Gosspium hirsutum L.) is classified as a salt tolerant crop. However, its yield and fiber quality are negatively affected by soil salinity. Studies on the enzymatic differences in sucrose metabolism under different soil salinity levels are lacking. Therefore, field experiments, using two cotton cultivars, CCRI-79 (salt-tolerant) and Simian 3 (salt-sensitive), were conducted in 2013 and 2014 at three different salinity levels (1.15 dS m-1 [low soil salinity], 6.00 dS m-1 [medium soil salinity], and 11.46 dS m-1 [high soil salinity]). The objective was to elucidate the effects of soil salinity on sucrose content and the activity of key enzymes that are related to sucrose metabolism in cotton fiber. Results showed that as the soil salinity increased, cellulose content, sucrose content, and sucrose transformation rate declined; the decreases in cellulose content and sucrose transformation rate caused by the increase in soil salinity were more in Simian 3 than those in CCRI-79. With increase in soil salinity, activities of sucrose metabolism enzymes sucrose phophate synthase (SPS), acidic invertase, and alkaline invertase were decreased, whereas sucrose synthase (SuSy) activity increased. However, the changes displayed in the SuSy and SPS activities in response to increase in soil salinity were different and the differences were large between the two cotton cultivars. These results illustrated that suppressed cellulose synthesis and sucrose metabolism under high soil salinity were mainly due to the change in SPS, SuSy, and invertase activities, and the difference in cellulose synthesis and sucrose metabolism in fiber for the two cotton cultivars in response to soil salinity was determined mainly by both SuSy and SPS activities.
- Published
- 2016
- Full Text
- View/download PDF
17. Effects of Soil Salinity on Sucrose Metabolism in Cotton Leaves.
- Author
-
Jun Peng, Jingran Liu, Lei Zhang, Junyu Luo, Helin Dong, Yan Ma, Xinhua Zhao, Binglin Chen, Ning Sui, Zhiguo Zhou, and Yali Meng
- Subjects
Medicine ,Science - Abstract
This study investigated sucrose metabolism of the youngest fully expanded main-stem leaf (MSL) and the subtending leaf of cotton (Gossypium hirsutum L.) boll (LSCB) of salt-tolerant (CCRI-79) and salt-sensitive (Simian 3) cultivars and its relationship to boll weight under low, medium and high soil salinity stress in Dafeng, China, in 2013 and 2014. The results showed that with increased soil salinity, 1) both the chlorophyll content and net photosynthetic rate (Pn) decreased, while the internal CO2 concentration firstly declined, and then increased in the MSL and LSCB; 2) carbohydrate contents in the MSL reduced significantly, while sucrose and starch contents in the LSCB increased, as did the activities of sucrose phosphate synthase (SPS) and sucrose synthase (SuSy) in both the MSL and LSCB; 3) but invertase activity in both the MSL and LSCB did not change significantly. Our study also showed that the LSCB was more sensitive to soil salinity than was the MSL. Of the measured physiological indices, higher SPS activity, mainly controlled by sps3, may contribute to adaption of the LSCB to soil salinity stress because SPS is beneficial for efficiently sucrose synthesis, reduction of cellular osmotic potential and combined actions of Pn, and sucrose transformation rate and SPS may contribute to the reduction in boll weight under soil salinity stress.
- Published
- 2016
- Full Text
- View/download PDF
18. The effects of fruiting positions on cellulose synthesis and sucrose metabolism during cotton (Gossypium hirsutum L.) fiber development.
- Author
-
Yina Ma, Youhua Wang, Jingran Liu, Fengjuan Lv, Ji Chen, and Zhiguo Zhou
- Subjects
Medicine ,Science - Abstract
Cotton (Gossypium hirsutum L.) boll positions on a fruiting branch vary in their contribution to yield and fiber quality. Fiber properties are dependent on deposition of cellulose in the fiber cell wall, but information about the enzymatic differences in sucrose metabolism between these fruiting positions is lacking. Therefore, two cotton cultivars with different sensitivities to low temperature were tested in 2010 and 2011 to quantify the effect of fruit positions (FPs) on fiber quality in relation to sucrose content, enzymatic activities and sucrose metabolism. The indices including sucrose content, sucrose transformation rate, cellulose content, and the activities of the key enzymes, sucrose phosphate synthase (SPS), acid invertase (AI) and sucrose synthase (SuSy) which inhibit cellulose synthesis and eventually affect fiber quality traits in cotton fiber, were determined. Results showed that as compared with those of FP1, cellulose content, sucrose content, and sucrose transformation rate of FP3 were all decreased, and the variations of cellulose content and sucrose transformation rate caused by FPs in Sumian 15 were larger than those in Kemian 1. Under FP effect, activities of SPS and AI in sucrose regulation were decreased, while SuSy activity in sucrose degradation was increased. The changes in activities of SuSy and SPS in response to FP effect displayed different and large change ranges between the two cultivars. These results indicate that restrained cellulose synthesis and sucrose metabolism in distal FPs are mainly attributed to the changes in the activities of these enzymes. The difference in fiber quality, cellulose synthesis and sucrose metabolism in response to FPs in fiber cells for the two cotton cultivars was mainly determined by the activities of both SuSy and SPS.
- Published
- 2014
- Full Text
- View/download PDF
19. Effect of late planting and shading on cellulose synthesis during cotton fiber secondary wall development.
- Author
-
Ji Chen, Fengjuan Lv, Jingran Liu, Yina Ma, Youhua Wang, Binglin Chen, Yali Meng, Zhiguo Zhou, and Derrick M Oosterhuis
- Subjects
Medicine ,Science - Abstract
Cotton-rapeseed or cotton-wheat double cropping systems are popular in the Yangtze River Valley and Yellow River Valley of China. Due to the competition of temperature and light resources during the growing season of double cropping system, cotton is generally late-germinating and late-maturing and has to suffer from the coupling of declining temperature and low light especially in the late growth stage. In this study, late planting (LP) and shading were used to fit the coupling stress, and the coupling effect on fiber cellulose synthesis was investigated. Two cotton (Gossypium hirsutum L.) cultivars were grown in the field in 2010 and 2011 at three planting dates (25 April, 25 May and 10 June) each with three shading levels (normal light, declined 20% and 40% PAR). Mean daily minimum temperature was the primary environmental factor affected by LP. The coupling of LP and shading (decreased cellulose content by 7.8%-25.5%) produced more severe impacts on cellulose synthesis than either stress alone, and the effect of LP (decreased cellulose content by 6.7%-20.9%) was greater than shading (decreased cellulose content by 0.7%-5.6%). The coupling of LP and shading hindered the flux from sucrose to cellulose by affecting the activities of related cellulose synthesis enzymes. Fiber cellulose synthase genes expression were delayed under not only LP but shading, and the coupling of LP and shading markedly postponed and even restrained its expression. The decline of sucrose-phosphate synthase activity and its peak delay may cause cellulose synthesis being more sensitive to the coupling stress during the later stage of fiber secondary wall development (38-45 days post-anthesis). The sensitive difference of cellulose synthesis between two cultivars in response to the coupling of LP and shading may be mainly determined by the sensitiveness of invertase, sucrose-phosphate synthase and cellulose synthase.
- Published
- 2014
- Full Text
- View/download PDF
20. Sentiment Orientation Analysis of Micro-lecture Comments Based on MacBERT-BiGRU Model.
- Author
-
Ruirui Sun, Cheng Peng, Jingran Liu, Chunling Li, and Yujun Zhou 0006
- Published
- 2023
- Full Text
- View/download PDF
21. The two-component signal transduction system ArlRS regulates Staphylococcus epidermidis biofilm formation in an ica-dependent manner.
- Author
-
Yang Wu, Jiaxue Wang, Tao Xu, Jingran Liu, Wenqi Yu, Qiang Lou, Tao Zhu, Nianan He, Haijing Ben, Jian Hu, Friedrich Götz, and Di Qu
- Subjects
Medicine ,Science - Abstract
Due to its ability to form biofilms on medical devices, Staphylococcus epidermidis has emerged as a major pathogen of nosocomial infections. In this study, we investigated the role of the two-component signal transduction system ArlRS in regulating S. epidermidis biofilm formation. An ArlRS-deficient mutant, WW06, was constructed using S. epidermidis strain 1457 as a parental strain. Although the growth curve of WW06 was similar to that of SE1457, the mutant strain was unable to form biofilms in vitro. In a rabbit subcutaneous infection model, sterile disks made of polymeric materials were implanted subcutaneously followed with inoculation of WW06 or SE1457. The viable bacteria cells of WW06 recovered from biofilms on the embedded disks were much lower than that of SE1457. Complementation of arlRS genes expression from plasmid in WW06 restored biofilm-forming phenotype both in vivo and in vitro. WW06 maintained the ability to undergo initial attachment. Transcription levels of several genes involved in biofilm formation, including icaADBC, sigB, and sarA, were decreased in WW06, compared to SE1457; and icaR expression was increased in WW06, detected by real-time reverse-transcription PCR. The biofilm-forming phenotype was restored by overexpressing icaADBC in WW06 but not by overexpressing sigB, indicating that ArlRS regulates biofilm formation through the regulation of icaADBC. Gel shift assay showed that ArlR can bind to the promoter region of the ica operon. In conclusion, ArlRS regulates S. epidermidis biofilm formation in an ica-dependent manner, distinct from its role in S. aureus.
- Published
- 2012
- Full Text
- View/download PDF
22. Monoclonal antibodies against accumulation-associated protein affect EPS biosynthesis and enhance bacterial accumulation of Staphylococcus epidermidis.
- Author
-
Jian Hu, Tao Xu, Tao Zhu, Qiang Lou, Xueqin Wang, Yang Wu, Renzheng Huang, Jingran Liu, Huayong Liu, Fangyou Yu, Baixing Ding, Yalin Huang, Wenyan Tong, and Di Qu
- Subjects
Medicine ,Science - Abstract
Because there is no effective antibiotic to eradicate Staphylococcus epidermidis biofilm infections that lead to the failure of medical device implantations, the development of anti-biofilm vaccines is necessary. Biofilm formation by S. epidermidis requires accumulation-associated protein (Aap) that contains sequence repeats known as G5 domains, which are responsible for the Zn(2+)-dependent dimerization of Aap to mediate intercellular adhesion. Antibodies against Aap have been reported to inhibit biofilm accumulation. In the present study, three monoclonal antibodies (MAbs) against the Aap C-terminal single B-repeat construct followed by the 79-aa half repeat (AapBrpt1.5) were generated. MAb(18B6) inhibited biofilm formation by S. epidermidis RP62A to 60% of the maximum, while MAb(25C11) and MAb(20B9) enhanced biofilm accumulation. All three MAbs aggregated the planktonic bacteria to form visible cell clusters. Epitope mapping revealed that the epitope of MAb(18B6), which recognizes an identical area within AapBrpt constructs from S. epidermidis RP62A, was not shared by MAb(25C11) and MAb(20B9). Furthermore, all three MAbs were found to affect both Aap expression and extracellular polymeric substance (EPS, including extracellular DNA and PIA) biosynthesis in S. epidermidis and enhance the cell accumulation. These findings contribute to a better understanding of staphylococcal biofilm formation and will help to develop epitope-peptide vaccines against staphylococcal infections.
- Published
- 2011
- Full Text
- View/download PDF
23. Polymeric assembled nanoparticles through kinetic stabilization by confined impingement jets dilution mixer for fluorescence switching imaging
- Author
-
Jingran Liu, Yue Wu, Jie Tang, Tao Wang, Feng Ni, Qiumin Wu, Xijiao Yang, null Ayyaz Ahmad, Naveed Ramzan, and Yisheng Xu
- Subjects
Environmental Engineering ,General Chemical Engineering ,General Chemistry ,Biochemistry - Published
- 2023
24. East Asian methane emissions inferred from high-resolution inversions of GOSAT and TROPOMI observations: a comparative and evaluative analysis
- Author
-
Ruosi Liang, Yuzhong Zhang, Jingran Liu, Wei Chen, Peixuan Zhang, Cuihong Chen, Huiqin Mao, Guofeng Shen, Zhen Qu, Zichong Chen, Minqiang Zhou, Pucai Wang, Robert J. Parker, Hartmut Boesch, Alba Lorente, Joannes D. Maasakkers, and Ilse Aben
- Abstract
We apply atmospheric methane column retrievals from two different satellite instruments (Greenhouse gases Observing SATellite – GOSAT; TROPOspheric Monitoring Instrument – TROPOMI) to a regional inversion framework to quantify East Asian methane emissions for 2019 at 0.5∘ × 0.625∘ horizontal resolution. The goal is to assess if GOSAT (relatively mature but sparse) and TROPOMI (new and dense) observations inform consistent methane emissions from East Asia with identically configured inversions. Comparison of the results from the two inversions shows similar correction patterns to the prior inventory in central northern China, central southern China, northeastern China, and Bangladesh, with less than 2.6 Tg a−1 differences in regional posterior emissions. The two inversions, however, disagree over some important regions, particularly in northern India and eastern China. The methane emissions inferred from GOSAT observations are 7.7 Tg a−1 higher than those from TROPOMI observations over northern India but 6.4 Tg a−1 lower over eastern China. The discrepancies between the two inversions are robust against varied inversion configurations (i.e., assimilation window and error specifications). We find that the lower methane emissions from eastern China inferred by the GOSAT inversion are more consistent with independent ground-based in situ and total column (TCCON) observations, indicating that the TROPOMI retrievals may have high XCH4 biases in this region. We also evaluate inversion results against tropospheric aircraft observations over India during 2012–2014 by using a consistent GOSAT inversion of earlier years as an intercomparison platform. This indirect evaluation favors lower methane emissions from northern India inferred by the TROPOMI inversion. We find that in this case the discrepancy in emission inference is contributed by differences in data coverage (almost no observations by GOSAT vs. good spatial coverage by TROPOMI) over the Indo-Gangetic Plain. The two inversions also differ substantially in their posterior estimates for northwestern China and neighboring Kazakhstan, which is mainly due to seasonally varying biases between GOSAT and TROPOMI XCH4 data that correlate with changes in surface albedo.
- Published
- 2023
25. Life events and parent style for mental health in children: a cross-sectional study
- Author
-
Yanlin, Li, Jiahui, Chu, Fang, Wen, Liping, Yu, Junjuan, Yan, Fang, Wang, Jingran, Liu, Ying, Li, and Yonghua, Cui
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
Life events and parenting styles might play an important role in children's mental health.This study aims to explore how life events and parenting styles influence children's mental health based on a Chinese sample.A total of 3535 participants had at least one mental disorder (positive group), while a total of 3561 participants had no mental disorders (negative group). The Child Behavior Checklist (CBCL), Adolescent Self-Rating Life Events Check List (ASLEC) and Egna Minnen Beträffande Uppfostran (EMBU) were used for screening these two groups.CBCL total scores differed significantly by sex in the Positive group according to the Mann-Whitney tests (Z = -5.40, p 0.001). Multiple regression analyses showed that the dimensions of punishment (p = 0.014) and other (p = 0.048) in the ASLEC scale can significantly predict CBCL total scores in the Positive group. Sex, age and overprotection from the father were risk factors (p 0.001) according to binary logistic regression.Life events and parenting styles may have impacts on mental health. Fathers play a very important role in children's growth. Punitive education and fathers' overprotection might be risk factors for children's mental health.It is a large sample (3535) study of Chinese children and adolescents It provides evidence that life events and parenting styles have impacts on mental health and that fathers play a very important role in children's growth. It is conducive to the development of interventions for the mental health of children and adolescents.
- Published
- 2022
26. Altered brain activity and functional networks in school‐age boys with severe haemophilia A: A resting‐state functional magnetic resonance imaging study
- Author
-
Di Hu, Jingran Liu, Guoqing Liu, Shasha Hu, Zekun Li, Yunyun Wei, Ningning Zhang, Runhui Wu, and Yun Peng
- Subjects
Male ,Brain Mapping ,Brain ,Humans ,Hematology ,General Medicine ,Nerve Net ,Child ,Hemophilia A ,Magnetic Resonance Imaging ,Genetics (clinical) - Abstract
Microstructural alterations of brain structure in haemophilic boys were found in our previous study.We investigated alterations of brain function in school-age boys with severe haemophilia A (HA) with resting-state functional magnetic resonance imaging (rs-fMRI).We obtained rs-fMRI scans from 24 boys with HA and 25 demographically matched healthy children. Spontaneous brain activity parameters were calculated. Graph theoretical analyses on rs-fMRI data at the global and regional levels were performed. Two-sample t tests were used to analyze differences, and correlation analyses identified relationships between altered neural properties and psychological characteristics.Children with severe HA showed small-worldness organization but with an increased efficiency and compactness in functional segregation. The whole brain showed an overtight connection pattern. At the regional level, significantly increased nodal efficiency in the salience network (SN), default mode network (DMN) and executive control network was found. Social Anxiety Scale for Children (SASC) scores were positively correlated with these alterations. Spontaneous brain activity alterations in regions including the cerebellum, frontal gyrus (orbital part), temporal gyrus and thalamus were observed; some of these regions have been closely related to social anxiety and family or social support.Our study is the first to evaluate the neurological functional changes in school-age boys with severe HA. Disruptions in topographic characteristics and abnormal activity were closely related to social conditions. These data could help us to understand early neurological alterations in haemophilic children, improve the traditional view of family support and strengthen normal school life at an early stage.
- Published
- 2022
27. Spray drying-assisted construction of hierarchically porous ZIF-8 for controlled release of doxorubicin
- Author
-
Yan Wei, Miao Chang, Jingran Liu, Ni Wang, and Jie-Xin Wang
- Subjects
Drug Carriers ,Drug Liberation ,Drug Delivery Systems ,Doxorubicin ,Delayed-Action Preparations ,Humans ,Spray Drying ,General Materials Science ,Porosity ,HeLa Cells - Abstract
The intrinsic properties and structure of carrier materials, as well as the drug-loading method, are crucial to the fabrication of high-performance controlled drug release systems. Metal-organic frameworks (MOFs) have attracted great attention in drug delivery due to their rich variety and very precisely designable structures, but their inherent small pores limit their application towards large-size drug molecules. Herein, we report a facile and efficient approach for the construction of hierarchically porous ZIF-8 (HP-ZIF-8) by spray drying. The homogeneously distributed mesopores, which result from the interspaces in the closely arranged nanosized ZIF-8 (N-ZIF-8), can be tuned by adjusting the primary particle size. More importantly, a drug (doxorubicin (DOX), for example) can be simultaneously encapsulated during the fabrication process of HP-ZIF-8, achieving a high loading rate of 79% and an encapsulation efficiency of 79%. Furthermore, we demonstrate that the obtained DOX@HP-ZIF-8 is a pH-responsive system and the release can also be controlled by the mesopore size. Although HP-ZIF-8 shows obvious advantages in drug loading and release performance compared with N-ZIF-8 loaded with DOX by the same solvent adsorption approach, DOX@HP-ZIF-8 displays significantly increased loading capacity (more than 3 times) and the slowest release rate due to its drug-loading method. Their therapeutic efficacy on HeLa cells has also been proved. These findings have important implications for the construction of HP-MOFs as drug carriers and will also present a new platform for controlled drug release and biomedical applications.
- Published
- 2022
28. Supplementary material to 'East Asian methane emissions inferred from high-resolution inversions of GOSAT and TROPOMI observations: a comparative and evaluative analysis'
- Author
-
Ruosi Liang, Yuzhong Zhang, Jingran Liu, Wei Chen, Peixuan Zhang, Cuihong Chen, Huiqin Mao, Guofeng Shen, Zhen Qu, Zichong Chen, Minqiang Zhou, Pucai Wang, Robert J. Parker, Hartmut Boesch, Alba Lorente, Joannes D. Maasakkers, and Ilse Aben
- Published
- 2022
29. Grey matter abnormalities in Tourette syndrome: an activation likelihood estimation meta-analysis
- Author
-
Jingran Liu, Fang Wen, Fang Wang, Junjuan Yan, Ying Li, Liping Yu, and Yonghua Cui
- Subjects
Grey matter ,Lentiform nucleus ,lcsh:RC435-571 ,Thalamus ,Neuroimaging ,Tourette syndrome ,Gyrus Cinguli ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Psychiatry ,Medicine ,Humans ,Gray Matter ,Likelihood Functions ,business.industry ,Postcentral gyrus ,Brain ,Anatomy ,Voxel-based morphometry ,medicine.disease ,Magnetic Resonance Imaging ,030227 psychiatry ,Psychiatry and Mental health ,medicine.anatomical_structure ,nervous system ,ALE ,business ,Insula ,030217 neurology & neurosurgery ,Research Article - Abstract
Background Tourette syndrome (TS) is a neurodevelopmental disorder defined by the continual presence of primary motor and vocal tics. Grey matter abnormalities have been identified in numerous studies of TS, but conflicting results have been reported. This study was an unbiased statistical meta-analysis of published neuroimaging studies of TS structures. Methods A voxel quantitative meta-analysis technique called activation likelihood estimation (ALE) was used. The meta-analysis included six neuroimaging studies involving 247 TS patients and 236 healthy controls. A statistical threshold of p Results We found that grey matter volumes were significantly increased in the bilateral thalamus, right hypothalamus, right precentral gyrus, left postcentral gyrus, left inferior parietal lobule, right lentiform nucleus, and left insula of TS patients compared to those of healthy controls. In contrast, grey matter volumes were significantly decreased in the bilateral postcentral gyrus, bilateral anterior cingulate, bilateral insula, left posterior cingulate and left postcentral gyrus of TS patients compared to those of healthy controls. Conclusions Our present meta-analysis primarily revealed significant increases in grey matter volumes in the thalamus and lentiform nucleus, and decreased grey matter volumes in the anterior cingulate gyrus, of TS patients compared to those in healthy controls. Most of these identified regions are associated with cortico-striato-thalamo-cortical circuits. Further studies with larger sample sizes are needed to confirm these changes in grey matter volumes in TS patients.
- Published
- 2021
30. Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder and Tic Disorder: A Quick Review
- Author
-
Ying Li, Yonghua Cui, Jingran Liu, Fang Wang, Fang Wen, Junjuan Yan, Yanlin Li, and Liping Yu
- Subjects
Male ,Obsessive-Compulsive Disorder ,Treatment Outcome ,General Neuroscience ,Tic Disorders ,Motor Cortex ,Humans ,General Medicine ,Transcranial Magnetic Stimulation - Abstract
Repetitive transcranial megnetic stimulation (rTMS) has been widely used in patients with psychiatric disorders. Previous studies revealed good efficacy of rTMS for patients with obsession-compulsive disorder (OCD) and Tic disorder (TD). OCD and TD are closely related and considered to etiologically overlap. Patients with the co-occurrence of OCD and TD are often identified. Therefore, we conducted a quick review of rTMS for the treatment of these two diseases to compare the similarities and differences of rTMS for OCD and TD, which might provide an indication for the treatment of the co-occurrence of OCD and TD. We searched articles published in PubMed, Wanfang, and Web of Science from January 2001 to January 2022. Both inclusion criteria and exclusion criteria were developed to identify the relevant included studies. Data on the frequency, target area, sample size, and number of males, especially the rTMS treatment procedure or parameters, were extracted in the included studies. We included 26 studies on OCD and 12 studies on TD in this quick review. A total of 996 participants were included. Based on the review of the included studies, lowfrequency rTMS might be used more than high-frequency rTMS, and the supplementary motor area (SMA) might show better efficacy than the dorsolateral prefrontal cortex (DLPFC) in OCD. For patients with TD, low-frequency rTMS located in the SMA might show good efficacy both in OCD and TD. Our quick review elaborated the treatment efficacy of rTMS for both patients with OCD and those with TD. It seems that the SMA is an important target choice for both OCD and TD patients. Low-frequency rTMS might be used more than high-frequency rTMS in both OCD and TD patients. In future studies, we should explore more about the efficacy of rTMS for patients with co-occurring OCD and TD, especially for the efficacy of targeted SMA with low frequency.
- Published
- 2022
31. The efficacy and safety in attention deficit hyperactivity disorder of second-generation antipsychotics and other medications for hyperactivity in children and adolescents with autism: a meta-analysis
- Author
-
Yonghua Cui, Ying Li, Liping Yu, Junjuan Yan, Fang Wen, Fang Wang, and Jingran Liu
- Subjects
China ,Pediatrics ,medicine.medical_specialty ,Adolescent ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,Attention deficit hyperactivity disorder ,Pharmacology (medical) ,Autistic Disorder ,Child ,Adverse effect ,Randomized Controlled Trials as Topic ,business.industry ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Attention Deficit Disorder with Hyperactivity ,Strictly standardized mean difference ,Relative risk ,Meta-analysis ,Autism ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Somnolence ,Antipsychotic Agents - Abstract
Children and adolescents with ASD also have co-occurrence of attention deficit hyperactivity disorder (ADHD) symptoms. ADHD symptoms, especially hyperactivity, greatly increased the severity of autism symptoms. This study concentrated on two widely-used medications: the second generation of antipsychotics (SGAs) and ADHD medication, aiming to conduct a meta-analysis about their effect on hyperactivity, so it would offer some evidence for clinical medication choice. The Medline, Embase, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure databases were searched from inception to July 2019 for studies exploring the use of SGAs and ADHD medications in autistic children and adolescents. Double-blind, randomized controlled trials that reported hyperactivity as an outcome were included in the study. A total of thirteen trials with 712 participants were included in our meta-analysis. For SGAs, the standardized mean difference (SMD) of hyperactivity subscale in Aberrant behavior checklist scale or conners rating scales was 0.59, 95% confidence interval (CI): 0.23-0.96, I2 = 74%, Q = 15.34, P < 0.01. For ADHD medications, SMD was -0.66, with 95% CI: -0.99 to 0.33, I2 = 53%, Q = 15.02, P = 0.04. As for adverse events, in the SGAs group, somnolence had the largest effect size, risk ratio = 5.62, 95% CI: 3.20- 9.87 (I2 = 0%, Q = 2.45, P = 0.65). In ADHD group, the side effect of decreased appetite showed the largest effect size (risk ratio = 2.63, 95% CI = 0.99-7.01, I2 = 65.7%, Q = 11.66, P = 0.02). Both ADHD medications and SGAs were effective in dealing with hyperactivity in children and adolescents with autism but were shown to increase the risk of decreased appetite, somnolence, headache and nausea or vomiting. The clinical use of these medications should carefully weigh the benefits and risks.
- Published
- 2021
32. Macro-Meso-Microporous Metal-Organic Frameworks: Template-Assisted Spray Drying Synthesis and Enhanced Catalysis
- Author
-
Ni Wang, Yan Wei, Miao Chang, Jingran Liu, and Jie-Xin Wang
- Subjects
General Materials Science - Abstract
Hierarchically porous metal-organic frameworks (HP-MOFs) are promising in many applications. However, most previous studies focus on HP-MOFs with two kinds of pore structures. Herein, a strategy for efficient construction of HP-MOFs possessing macro-meso-micropores using template-assisted spray drying followed by etching process is proposed. Taking ZIF-8 as an example, using polystyrene (PS) templates, the complete HP-ZIF-8 with all the three categories of pores can be easily fabricated. The close arrangement of intrinsic microporous nanosized ZIF-8 (N-ZIF-8) in the spray drying process results in the creation of mesopores, while the macropores are further generated after the removal of PS templates. The structures of macropores and mesopores can be easily adjusted by altering the size and proportion of PS and the size of N-ZIF-8, respectively. Furthermore, this method is extended to the preparation of HP-HKUST-1. As a proof-of-concept, HP-ZIF-8 displays excellent catalytic properties in Knoevenagel reaction owing to its unique pore features. Compared with conventional microsized ZIF-8 (M-ZIF-8) with similar size, HP-ZIF-8 achieves the significantly increased conversion of benzaldehyde from 55% to 100% within 3 h, and shows better recycling performance than N-ZIF-8.
- Published
- 2022
33. The Polysaccharide Extracts from Astragalus Mongholicus Bunge Protects Mice from Acetaminophen-Induced Hepatotoxicity by Modulating the Nrf-2/ARE, JNK and Autophagy Pathways
- Author
-
Xinyi Li, Mingyue Zhong, Jingran Liu, Guoquan Xu, Yan Yan, Jian Huang, Haisheng Yuan, Yuzhen Wang, and Minhui Li
- Subjects
History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
34. Comprehensive Understanding of Gold Nanoparticles Enhancing Catalytic Efficiency
- Author
-
Jinru Zhang, Jingran Liu, Min Wu, Xin Li, Pei Gong, and Fang Wan
- Subjects
chemistry.chemical_classification ,010304 chemical physics ,biology ,02 engineering and technology ,Surfaces and Interfaces ,Cellulase ,021001 nanoscience & nanotechnology ,01 natural sciences ,Combinatorial chemistry ,Catalysis ,Nanomaterials ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,Enzyme ,chemistry ,Colloidal gold ,Yield (chemistry) ,0103 physical sciences ,biology.protein ,Physical and Theoretical Chemistry ,Cellulose ,Catalytic efficiency ,0210 nano-technology - Abstract
Enzymes play significant roles in both life and industry, and increasing enzymatic activity has been a long-term goal of the biochemical science. Recently, it has been reported that nanomaterials can enhance both the specificity and yield of polymerase chain reaction (PCR) though the mechanism of this enhancement remained unclear. By using gold nanoparticles (AuNPs) as model nanomaterials and the cellulase as a typical enzyme, we studied whether and how nanomaterials affect enzymatic activities investigating various aspects of the reaction process. The results showed that the catalytic efficiency of cellulase depends on the concentration of AuNPs. By detailed studying the relation between catalysis and experimental conditions, we found that the enzymatic activity can be increased up to 13.13% upon adding AuNPs in concentration of 0.5 nM into the reaction solution. The optimal pH, temperature, and incubation time for cellulose with 0.5 nM AuNPs were found to be same as those for the cellulose alone. These findings might be useful for enhancing enzymatic activities in the industrial processes.
- Published
- 2020
35. Interfacial properties of ultrahigh methoxylated pectin
- Author
-
Mingming Wang, Yanping Cao, Jing Tan, Ruijin Yang, Jingran Liu, Zhumao Jiang, and Xiao Hua
- Subjects
food.ingredient ,Pectin ,Surface Properties ,Intrinsic viscosity ,Analytical chemistry ,02 engineering and technology ,Microscopy, Atomic Force ,Biochemistry ,Micelle ,Surface tension ,03 medical and health sciences ,symbols.namesake ,Gibbs isotherm ,food ,Microscopy, Electron, Transmission ,Structural Biology ,Surface Tension ,Citrus Pectin ,Particle Size ,Molecular Biology ,Micelles ,030304 developmental biology ,0303 health sciences ,Viscosity ,Chemistry ,General Medicine ,021001 nanoscience & nanotechnology ,Molecular Weight ,Kinetics ,Transmission electron microscopy ,Critical micelle concentration ,symbols ,Pectins ,Emulsions ,Beta vulgaris ,Rheology ,Shear Strength ,0210 nano-technology - Abstract
The interfacial properties of ultrahigh methoxylated pectin (UHMP) prepared via esterification of citrus pectin (CP) were investigated. The intrinsic viscosity ([η]) of pectin was significantly decreased from 1211.5 mL/g to 294.9 mL/g as the degree of methylation (DM) increased from 63.18 ± 0.08% to 91.52 ± 0.11%. Surface tension (γ) analysis indicated that UHMP had a critical micelle concentration (CMC) of 0.8 g/L, which was slightly smaller than that of sugar beet pectin (SBP) (1.0 g/L). The morphology of the UHMP aggregation presented a network structure and irregular clusters at 10 μg/mL and 1 μg/mL based on atomic force microscopy (AFM). Transmission electron microscopy (TEM) observations further confirmed the self-aggregation behaviours and rod-like micelles of UHMP. The surface excess (Γ) was 1.69 ± 0.17 μmol/m2 for UHMP, which was lower than the values of SBP (1.88 ± 0.21 μmol/m2) and CP (2.91 ± 0.57 μmol/m2). Correspondingly, UHMP possessed the highest molecular area (A) of 0.99 ± 0.10 nm2. Thus, UHMP was proposed to be more flexible and extendable at the interface. The interfacial shear rheology study suggested that UHMP was able to form an elastic-dominant interfacial film to stabilize the oil/water interface.
- Published
- 2020
36. High Soil Available Phosphorus Favors Carbon Metabolism in Cotton Leaves in Pot Trials
- Author
-
Jun Peng, Zongyun Li, Li Pengcheng, Helin Dong, Zheng Cangsong, Miao Sun, Houqiang Xia, and Jingran Liu
- Subjects
0106 biological sciences ,0301 basic medicine ,Sucrose ,biology ,Phosphorus ,fungi ,RuBisCO ,food and beverages ,chemistry.chemical_element ,Plant Science ,Photosynthesis ,01 natural sciences ,03 medical and health sciences ,Horticulture ,chemistry.chemical_compound ,030104 developmental biology ,Invertase ,chemistry ,Dry weight ,biology.protein ,Sucrose-phosphate synthase ,Sugar ,Agronomy and Crop Science ,010606 plant biology & botany - Abstract
Phosphorus (P) is an essential macronutrient for plant growth and its metabolism. Because reproductive growth could be influenced by carbon metabolism of the functional leaf (MSL), we hypothesized that soil available phosphorus (AP) deficiency would limit boll dry mass distributions of the whole cotton plant by decreasing photosynthesis of MSL and inhibiting carbon metabolism in the MSL. This study aimed to determine the correlations between carbon metabolism and cotton boll dry mass in relation to soil AP deficiency, and key carbon-metabolism enzymes responsive to P for different low-P-sensitive cultivars. A three-year (2015–2017) pot experiment was conducted with three available phosphorus (AP) levels [3 (P0, AP deficiency), 8 (P1), and 12 (P2, as a control) mg P2O5 kg−1] with two cotton cultivars (CCRI 79 and LMY 28). Low soil AP had significant decreases on leaf P content, net photosynthetic rate (Pn) in the functional leaf (MSL), as well as boll dry mass. The P0 and P1 caused a significant increase in nonstructural carbohydrates (soluble sugar, sucrose, hexose, starch), in especial sucrose (↑8–17% for CCRI 79 and ↑20–32% for LMY 28). Similarly, the lower P levels (P0 and P1) prominently down-regulated the activities of Rubisco, sucrose phosphate synthase (SPS), and amylase, but up-regulated cytosolic fructose-1,6-bisphosphatases and soluble acid invertase (SAI). Moreover, only the absolute value of slope in SAI for LMY 28 was higher than that for CCRI 79 in 2015 and 2016. Our results indicated that the response of carbon-metabolizing enzymes to low AP content was mediated by SAI for CCRI 79 and LMY 28. In our results, Pn, Rubisco, and SAI were the dominant factors affecting the boll dry mass under low soil AP.
- Published
- 2020
37. Rapid construction of hierarchically porous metal–organic frameworks by a spray‐drying strategy for enhanced tannic acid adsorption
- Author
-
Jingran Liu, Ni Wang, Jie-Xin Wang, Miao Chang, Dan Wang, and Wei Yan
- Subjects
Porous metal ,Environmental Engineering ,Materials science ,General Chemical Engineering ,Rapid construction ,Composite number ,chemistry.chemical_compound ,Adsorption ,Chemical engineering ,chemistry ,Spray drying ,Tannic acid ,Metal-organic framework ,Biotechnology - Published
- 2021
38. Genome-wide identification, characterisation and expression profile analysis of DEAD-box family genes in sweet potato wild ancestor Ipomoea trifida under abiotic stresses
- Author
-
Jingran Liu, Panpan Zhu, Rong Wan, Tao Xu, Zhengmei Yang, and Qinghe Cao
- Subjects
Models, Molecular ,0106 biological sciences ,0301 basic medicine ,Protein family ,Biology ,Genes, Plant ,Ipomoea ,Plant Roots ,Salt Stress ,01 natural sciences ,Biochemistry ,Genome ,DEAD-box RNA Helicases ,03 medical and health sciences ,Gene Expression Regulation, Plant ,Stress, Physiological ,Databases, Genetic ,Genetics ,Gene family ,RNA-Seq ,Ipomoea batatas ,Molecular Biology ,Gene ,Phylogeny ,Abiotic component ,Phylogenetic tree ,Abiotic stress ,Cold-Shock Response ,Chromosome Mapping ,food and beverages ,biology.organism_classification ,Droughts ,Plant Leaves ,030104 developmental biology ,Organ Specificity ,Genome, Plant ,Heat-Shock Response ,Genome-Wide Association Study ,010606 plant biology & botany - Abstract
DEAD-box protein family is the largest subfamily of RNA helicases and plays an important role in RNA metabolism and plant growth, development, and stress responses. Although DEAD-box genes have been characterized in various major crop plants, their identification and characterization in Convolvulaceae is still in infancy. Sweet potato (Ipomoea batatas, in Convolvulaceae) is the seventh most important crop in the world. Ipomoea trifida is one of the ancestors of sweet potato and is an effective resource for sweet potato cross-breeding. Identification and characterisation of DEAD-box transcription factors in sweet potato wild ancestor I. trifida genome. A systematic genome-wide analysis was conducted to identify the DEAD-box transcription factors in the I. trifida genome. We identified 17 ItfDEAD-box genes which distributed unevenly on the nine chromosomes of I. trifida and encoded 29 DEAD transcripts. The phylogenetic analysis classified the DEAD-box proteins into nine groups named I–IX. Homology model prediction of ItfDEAD-box proteins obtained 14 models which lay a preliminary foundation for the further functional exploration of the ItfDEAD-box proteins. The tissue-specific and abiotic stress-responsive expression profiles of ItfDEAD-box genes were analyzed in different tissues and under abiotic stress responses by RNA-seq data and confirmed by quantitative PCR analysis. Some genes were significantly up- or down-regulated by different abiotic stress, suggesting that ItfDEAD-box plays a crucial role in stress responses in I. trifida. The identification and gene expression of the ItfDEAD-box gene family might shed light on the function exploration of DEAD-box gene in I. trifida and promote the molecular breeding of sweet potato.
- Published
- 2020
39. Factors controlling groundwater chemical evolution with the impact of reduced exploitation
- Author
-
Fei Liu, Jiawen Zou, Jingran Liu, Jingkun Zhang, and Pinna Zhen
- Subjects
Earth-Surface Processes - Published
- 2022
40. Revisiting the structure of the Yale Global Tic Severity Scale (YGTSS) in a sample of Chinese children with tic disorders
- Author
-
Yonghua Cui, Fang Wen, Jingran Liu, Liping Yu, Yi Gu, Junjuan Yan, Fang Wang, and Ying Li
- Subjects
China ,medicine.medical_specialty ,Adolescent ,Tics ,Concurrent validity ,RC435-571 ,YGTSS ,Severity of Illness Index ,Confirmatory factor analysis ,Validity ,Cronbach's alpha ,medicine ,Child and adolescent psychiatry ,Humans ,Measurement invariance ,Child ,Psychiatry ,Phonic Tic ,Reproducibility of Results ,Reliability ,medicine.disease ,Psychiatry and Mental health ,Child, Preschool ,Tic Disorders ,Scale (social sciences) ,Psychology ,Research Article ,Tourette Syndrome ,Clinical psychology - Abstract
Background To the best of our knowledge, although the Chinese version of the Yale Global Tic Severity Scale (YGTSS) is widely used in child psychiatry departments in China, there is very little evidence focusing on the psychometric characteristics of the Chinese version of YGTSS. In this present study, we aim to re-examine the structure of the Chinese version of YGTSS and investigate its reliability and validity. Methods A total of 367 children and adolescents with tic disorders aged 5–16 years old participated in the study. The Cronbach’s alpha, test-retest reliability and concurrent validity will be calculated. Confirmatory Factor Analysis (CFA) also will be performed to assess the structure of YGTSS. Results The Cronbach’s alpha of the motor tic subscale of YGTSS was 0.84, for the phonic tic subscale of YGTSS, it was 0.90, but for the whole scale, it was 0.58. The test-retest reliability of YGTSS was 0.84. For the results of CFA, the Comparative Fit Index (CFI) of YGTSS based on the Two-Factor Model and Three-Factor Model was 0.97 and 0.96 respectively. The measurement invariance analysis suggested that the Two-Factor model of YGTSS across different age and sex groups was at the accepted level (≥0.90). Conclusion Overall, according to the results of this research, it suggested that the Chinese version of YGTSS showed good psychometric properties. It can be used in the assessment of tic disorders in the Chinese population. In the future, more comprehensive tools for assessing tics need to be further developed, which can cover the symptoms of premonitory urge and tic related obsessive-compulsive symptoms.
- Published
- 2021
41. Multi-Scale Structure–Mechanical Property Relations of Graphene-Based Layer Materials
- Author
-
Huasong Qin, Yilun Liu, and Jingran Liu
- Subjects
Technology ,Nanostructure ,Materials science ,graphene-based layer materials ,Modulus ,Nanotechnology ,Review ,law.invention ,law ,Scale structure ,multi-scale structure–property relations ,General Materials Science ,Nanoscopic scale ,Microscopy ,QC120-168.85 ,Mechanical property ,mechanical behaviors ,Graphene ,QH201-278.5 ,Engineering (General). Civil engineering (General) ,TK1-9971 ,hierarchical structures ,multi-scale optimization ,Descriptive and experimental mechanics ,Polymer composites ,Electrical engineering. Electronics. Nuclear engineering ,TA1-2040 ,Layer (electronics) - Abstract
Pristine graphene is one of the strongest materials known in the world, and may play important roles in structural and functional materials. In order to utilize the extraordinary mechanical properties in practical engineering structures, graphene should be assembled into macroscopic structures such as graphene-based papers, fibers, foams, etc. However, the mechanical properties of graphene-based materials such as Young’s modulus and strength are 1–2 orders lower than those of pristine monolayer graphene. Many efforts have been made to unveil the multi-scale structure–property relations of graphene-based materials with hierarchical structures spanning the nanoscale to macroscale, and significant achievements have been obtained to improve the mechanical performance of graphene-based materials through composition and structure optimization across multi-scale. This review aims at summarizing the currently theoretical, simulation, and experimental efforts devoted to the multi-scale structure–property relation of graphene-based layer materials including defective monolayer graphene, nacre-like and laminar nanostructures of multilayer graphene, graphene-based papers, fibers, aerogels, and graphene/polymer composites. The mechanisms of mechanical property degradation across the multi-scale are discussed, based on which some multi-scale optimization strategies are presented to further improve the mechanical properties of graphene-based layer materials. We expect that this review can provide useful insights into the continuous improvement of mechanical properties of graphene-based layer materials.
- Published
- 2021
42. Comparative Metabolomic and Transcriptome Analysis Reveal Distinct Flavonoid Biosynthesis Regulation Between Petals of White and Purple Phalaenopsis amabilis
- Author
-
Mingku Zhu, Xiaoqing Wu, Xiaoqing Meng, Lingya Gu, Jingran Liu, Ge Li, Tingting Dong, Yu Sun, and Zongyun Li
- Subjects
0106 biological sciences ,0301 basic medicine ,Genetics ,Phalaenopsis amabilis ,fungi ,food and beverages ,Plant Science ,Biology ,biology.organism_classification ,01 natural sciences ,WRKY protein domain ,03 medical and health sciences ,chemistry.chemical_compound ,Metabolic pathway ,030104 developmental biology ,Flavonoid biosynthesis ,chemistry ,Anthocyanin ,MYB ,Petal ,Phalaenopsis ,Agronomy and Crop Science ,010606 plant biology & botany - Abstract
Orchids (Phalaenopsis amabilis), renowned for their extraordinary floral diversity which implies the complex flower color development, are one of the most valuable research materials for molecular biology studies. However, the genetic mechanisms underlying flower color formation in this non-model plant remain unclear. Here, the biochemical and molecular basis of the flavonoid/anthocyanin biosynthesis between purple petal cultivar (PP) and white petal cultivar (WP) was investigated. The results revealed that 142 differential flavonoid-related metabolites were identified using LC–MS/MS method, and the primary anthocyanins were identified as cyanidin derivatives. Moreover, RNA-seq revealed a total of 9523 upregulated and 6941 downregulated genes were detected. GO and KEGG analysis of DEGs indicated metabolic pathways were preferentially upregulated in PP. The expression of most known genes encoding the enzymes in anthocyanin and related derivative biosynthesis was significantly higher in PP than in WP, especially the downstream ones. We hypothesized that altered flavanone and flavone accumulation may lead to pigment elimination in WP, and the limited flux in cyanidin biosynthesis pathway seems to be the most likely reason for the colorless petal. Besides, 115 differentially expressed regulatory genes relating to anthocyanin biosynthesis were also detected, including MYB, bHLH, WD40, WRKY, MADS and bZIP. Subsequently, high consistency was observed between the results of qRT-PCR and those of RNA-seq. collectively, this study provides a comprehensive metabolic and transcriptional dataset for Phalaenopsis, the informative list of candidate structural and regulatory genes associated with purple trait offer a valuable opportunity to unravel the genetic mechanism underlying flower color formation in Phalaenopsis.
- Published
- 2019
43. Unique twisted donor–acceptor cruciform π-architectures exhibiting aggregation-induced emission and stimuli-response behaviors
- Author
-
Chao Zhang, Hongke Zhou, Weiliang Yuan, Jianfang Cao, Jingran Liu, Yonghui Wang, Ying Wang, and Xingliang Liu
- Subjects
Materials science ,Process Chemistry and Technology ,General Chemical Engineering ,02 engineering and technology ,Conjugated system ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,Triphenylamine ,01 natural sciences ,Fluorescence ,Acceptor ,0104 chemical sciences ,Amorphous solid ,chemistry.chemical_compound ,Cruciform ,chemistry ,Intramolecular force ,0210 nano-technology ,Benzene - Abstract
Two twisted π-conjugated cruciform luminophores MDCS-TPA and FMDCS-TPA containing two conjugated donor and acceptor groups intersecting at the central benzene core have been rationally designed and successfully prepared. The two compounds display unique intramolecular charge-transfer (ICT) process from electron-rich triphenylamine and electron-poor cyanostyryl units, which are evidenced by theoretical calculations and spectral analysis. MDCS-TPA and FMDCS-TPA exhibit AIE effects with high fluorescence quantum yields of 0.321 and 0.312 in the solid state. Interestingly, MDCS-TPA and FMDCS-TPA possess the distinct mechanofluorochromic (MFC) behavior. The as-prepared powders of the two luminophores could emit strong green (491 nm) and yellow-green fluorescence (529 nm), and the fluorescence color changed into yellow (542 nm) and orange (576 nm) after grinding, respectively, giving the red shifts of 51 nm and 47 nm. Such mechanochromism is reversible by repeating both the grinding-fuming and grinding-annealing processes. The MFC behavior of MDCS-TPA and FMDCS-TPA originates from the transition between the crystalline and amorphous states and the red-shifts induced by grinding is the result of the planarization of the molecular conformation and subsequent planar intramolecular charge transfer (PICT) under the external force stimuli.
- Published
- 2019
44. The clinical intervention choice for pediatric tic disorder patients from a tertiary children's hospital in China: a large-scale retrospective study based on electronic medical records
- Author
-
Ying Li, Junjuan Yan, Jishui Zhang, Jingran Liu, Yonghua Cui, Fang Wen, Liping Yu, Fang Wang, and Zihan Ma
- Subjects
Pediatrics ,medicine.medical_specialty ,Tic disorder ,China ,MEDLINE ,Traditional Chinese medicine ,Tiapride ,Tertiary Care Centers ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Intervention (counseling) ,mental disorders ,medicine ,Electronic Health Records ,Humans ,Pharmacology (medical) ,Child ,Retrospective Studies ,business.industry ,Medical record ,Retrospective cohort study ,medicine.disease ,Hospitals, Pediatric ,030227 psychiatry ,Clonidine ,Psychiatry and Mental health ,chemistry ,Tic Disorders ,business ,human activities ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Pharmacological intervention played an important role in the management of tic disorder. Large-scale prescription data for pediatric tic disorder patients in the real-world setting were scarce. The demographic and prescription data of tic disorder were extracted from the electronic medical records database of Beijing Children's Hospital from 2018 to 2020. The intervention choice for outpatient pediatric tic disorder patients was analyzed. A total of 20 417 patients were included, 28.1% (n = 5028) of them did not receive any pharmacological treatment. Over 70% were prescribed with anti-tic medication. For children less than 6 years of age, clonidine adhesive patches (CAPs) and traditional Chinese medicine (TCM) were the common choice. With the age growing, the use of antipsychotics was on the rise; 22% (n = 3389) were prescribed for at least two anti-tic medication, and the most common medication combination group was tiapride and TCM (33.7%), followed by CAP and TCM (22.1%). The clinical intervention choice for tic disorder is highly individualized. The pharmacological choice was influenced by severity, duration of symptom, age, the acceptance of parents and other factors.
- Published
- 2021
45. Classification of tic disorders based on functional MRI by machine learning: a study protocol
- Author
-
Fang Wang, Fang Wen, Jingran Liu, Junjuan Yan, Liping Yu, Ying Li, and Yonghua Cui
- Subjects
Machine Learning ,Tic Disorders ,Tics ,Humans ,General Medicine ,Child ,Magnetic Resonance Imaging ,Tourette Syndrome - Abstract
IntroductionTic disorder (TD) is a common neurodevelopmental disorder in children, and it can be categorised into three subtypes: provisional tic disorder (PTD), chronic motor or vocal TD (CMT or CVT), and Tourette syndrome (TS). An early diagnostic classification among these subtypes is not possible based on a new-onset tic symptom. Machine learning tools have been widely used for early diagnostic classification based on functional MRI (fMRI). However, few machine learning models have been built for the diagnostic classification of patients with TD. Therefore, in the present study, we will provide a study protocol that uses the machine learning model to make early classifications of the three different types of TD.Methods and analysisWe planned to recruit 200 children aged 6–9 years with new-onset tic symptoms and 100 age-matched and sex-matched healthy controls under resting-state MRI scanning. Based on the neuroimaging data of resting-state fMRI, the support vector machine (SVM) model will be built. We planned to construct an SVM model based on functional connectivity for the early diagnosis classification of TD subtypes (including PTD, CMT/CVT, TS).Ethics and disseminationThis study was approved by the ethics committee of Beijing Children’s Hospital. The trial results will be submitted to peer-reviewed journals for publication.Trial registration numberChiCTR2000033257.
- Published
- 2022
46. The Psychometric Properties of Children’s Yale-Brown Obsessive-Compulsive Scale in Tic Disorders
- Author
-
Mengyu Wang, Jingran Liu, Liping Yu, Yonghua Cui, Ying Li, Yanlin Li, Yi Gu, Jiahui Chu, Fang Wang, Fang Wen, and Junjuan Yan
- Subjects
Yale–Brown Obsessive Compulsive Scale ,medicine.diagnostic_test ,medicine ,Psychology ,Clinical psychology - Abstract
Background: Patients with Tic Disorders (TD) usually comorbid with Obsessive-compulsive disorder (OCD). The severity of obsessive-compulsive symptoms (OCS) in TD is widely evaluated via the Children’s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). However, the reliability and validity of CY-BOCS in TD patients are still unclear. Methods: In this study, we examined the psychometric properties of the Chinese version of the CY-BOCS in patients with tic disorders. Results: We examined the psychometric properties of the CY-BOCS in 367 patients with TD in China. We performed reliability and validity analyses on the CY-BOCS and found that the Cronbach’s Alpha and the test-retest reliability of CY-BOCS were 0.809 and 0.821 respectively. The CY-BOCS showed good consistency in the two-factor structure, namely the “obsession” and the “compulsive” factors (the comparative fit index was 0.84). Conclusion: The CY-BOCS has good psychometric properties in children and adolescents with TD. It suggests that the CY-BOCS could be widely used in Chinese children and adolescents with TD, especially for the TS patients.
- Published
- 2021
47. Long-Term Outcome of Pediatric Obsessive-Compulsive Disorder: A Meta-Analysis
- Author
-
Junjuan Yan, Jingran Liu, Chunmei Yan, Fang Wen, Fang Wang, Liping Yu, Yonghua Cui, and Ying Li
- Subjects
Pediatrics ,medicine.medical_specialty ,Obsessive-Compulsive Disorder ,Time Factors ,Adolescent ,business.industry ,Outcome (game theory) ,Term (time) ,Psychiatry and Mental health ,Obsessive compulsive ,Meta-analysis ,Pediatrics, Perinatology and Child Health ,Mental Health Recovery ,medicine ,Humans ,Pharmacology (medical) ,business ,Child ,Follow-Up Studies - Abstract
Objective: The outcome of pediatric obsessive-compulsive disorder (OCD) is still unclear. In the present study, long-term rates and predictors of remission were used to identify potential factors i...
- Published
- 2021
48. Additional file 1 of Grey matter abnormalities in Tourette syndrome: an activation likelihood estimation meta-analysis
- Author
-
Wen, Fang, Junjuan Yan, Liping Yu, Wang, Fang, Jingran Liu, Li, Ying, and Cui, Yonghua
- Subjects
Data_FILES - Abstract
Additional file 1.
- Published
- 2021
- Full Text
- View/download PDF
49. Does the High-Level Talent Introduction Policy Promote the Rise of Urban Housing Price? Evidence from 11 Cities in China
- Author
-
Jingran Liu, Feng Peng, and Yihao Tian
- Subjects
Development economics ,Economics ,China - Published
- 2021
50. Enhanced energy storage properties of BaO-K2O-Nb2O5-SiO2 glass ceramics obtained through microwave crystallization
- Author
-
Jingran Liu, Jiwei Zhai, Jia Tian, Shujian Wang, Bo Shen, and Ke Yang
- Subjects
Diffraction ,Materials science ,Process Chemistry and Technology ,02 engineering and technology ,Dielectric ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Microstructure ,01 natural sciences ,Energy storage ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,law.invention ,law ,visual_art ,Phase (matter) ,Materials Chemistry ,Ceramics and Composites ,visual_art.visual_art_medium ,Ceramic ,Crystallization ,Composite material ,0210 nano-technology ,Microwave - Abstract
BaO-K 2 O-Nb 2 O 5 -SiO 2 (BKNS) glass ceramics were prepared by microwave crystallization of transparent glass matrices and the effects of microwave treatment temperature on their dielectric performances, phase structure, microstructure and breakdown strength (BDS) were investigated systematically. X-ray diffraction results suggested that microwave treatment had no significant influence on the type of precipitated phases. The microstructure of the glass ceramics was remarkably optimized via microwave treatment. The dielectric constant and breakdown strength of microwave-treated samples were significantly improved as compared with conventional-heated samples at the same temperature. The maximum theoretical energy storage density of microwave-treatment samples at 750 °C reached 12.7 J/cm 3 , which was larger than that of the conventional-heated samples (8.6 J/cm 3 ).
- Published
- 2018
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.